Gene Information

Name : FN1765 (FN1765)
Accession : NP_602579.1
Strain : Fusobacterium nucleatum ATCC 25586
Genome accession: NC_003454
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 258113 - 259540 bp
Length : 1428 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence : 
GTGAGGAGTTTGAAAAAAACAAAAATAGTTTGTACTATTGGTCCTGTGACTGAATCAGTAGAAACTTTAAAAGAATTACT
AAATAGGGGAATGAATGTAATGAGATTGAATTTCTCTCATGGTGATTATGAAGAACATGGAATGAGAATGAAGAATTTTA
GACAAGCAATGTCTGAAACTGGAATTAGAGGAGGAATACTTCTTGATACTAAGGGTCCAGAAATAAGAACAATGACTTTA
AAAGATGGAAAAGATGTAAGTATTAAGGCTGGACAAAAATTTACTTTCACAACAGATCAATCGGTTGTTGGAGATAATGA
AAGAGTAGCAGTAACTTATGAAAATTTTGCAAAAGATTTAAAAGTTGGAAATATGGTTCTTGTTGATGATGGATTATTAG
AACTAGATGTTGTGGAAATAAAAGGAAATGAAGTTATATGTATAGCCAGAAATAATGGAGATCTAGGACAAAAGAAAGGA
ATAAATTTACCTAATGTTTCTGTTAATTTACCAGCATTATCTGAGAAAGATATAGAAGATCTAAAATTTGGTTGTCAAAA
TAATGTTGATTTTGTGGCAGCATCATTTATAAGAAAAGCTGATGATGTAAGACAAGTAAGAAAAGTTCTTAGAGAAAATG
ATGGAGAAAGAATACAAATAATTTCTAAGATAGAAAGCCAGGAAGGGCTTGATAATTTTGATGAAATTTTAGCAGAATCT
GATGGTATAATGGTAGCAAGAGGAGACTTAGGTGTAGAAATCCCTGTTGAAGAAGTTCCTTGTGCGCAAAAAATGATGAT
AAGAAAATGTAATAGAGTAGGAAAAACTGTTATTACAGCAACTCAAATGCTAGATTCAATGATTAAAAATCCAAGACCTA
CAAGAGCAGAAGCAAATGATGTTGCCAATGCTATATTAGATGGTACAGATGCAGTAATGCTTTCAGGTGAAACTGCAAAG
GGAAAATATCCATTAGCAGCTGTTGAAGTTATGAATAAAATAGCTAAAAAAGTTGATGCTACAATACCACCATTTTACAT
AGAAGGTGTTATAAATAAAAATGATATAACTTCTGCTGTTGCAGAAGGAAGTGCTGACATAAGCGAAAGGTTAAATGCAA
AACTTATAGTTGTTGGTACAGAATCTGGAAGAGCTGCAAGAGACATGAGAAGATATTTCCCTAGAGCACATATTTTAGCA
ATAACTAATAATGAAAAAACTGCAAATCAATTAGTTTTATCAAGAGGGATAATTTCATATGTAGATGCTTCACCAAAAAC
TTTAGAAGAATTCTTTGTTGTAGCAGAATCTGTTGCAAAAAAATTAAATTTAGTTAAAAATAATGATATAATTATAGCAA
CTTGTGGAGAAAGTGTATTTATACAAGGAACAACTAACTCAATAAAAGTAATACAAGTAAAAGCATAG

Protein sequence : 
MRSLKKTKIVCTIGPVTESVETLKELLNRGMNVMRLNFSHGDYEEHGMRMKNFRQAMSETGIRGGILLDTKGPEIRTMTL
KDGKDVSIKAGQKFTFTTDQSVVGDNERVAVTYENFAKDLKVGNMVLVDDGLLELDVVEIKGNEVICIARNNGDLGQKKG
INLPNVSVNLPALSEKDIEDLKFGCQNNVDFVAASFIRKADDVRQVRKVLRENDGERIQIISKIESQEGLDNFDEILAES
DGIMVARGDLGVEIPVEEVPCAQKMMIRKCNRVGKTVITATQMLDSMIKNPRPTRAEANDVANAILDGTDAVMLSGETAK
GKYPLAAVEVMNKIAKKVDATIPPFYIEGVINKNDITSAVAEGSADISERLNAKLIVVGTESGRAARDMRRYFPRAHILA
ITNNEKTANQLVLSRGIISYVDASPKTLEEFFVVAESVAKKLNLVKNNDIIIATCGESVFIQGTTNSIKVIQVKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-128 61
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-128 61
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-128 61
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 1e-127 61

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
FN1765 NP_602579.1 pyruvate kinase VFG0479 Protein 9e-129 61