Gene Information

Name : rpoB (OTBS_0208)
Accession : YP_001248196.1
Strain : Orientia tsutsugamushi Boryong
Genome accession: NC_009488
Putative virulence/resistance : Unknown
Product : DNA-directed RNA polymerase subunit beta
Function : -
COG functional category : K : Transcription
COG ID : COG0085
EC number : 2.7.7.6
Position : 197772 - 201905 bp
Length : 4134 bp
Strand : -
Note : DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme

DNA sequence :
ATGCAATACTTATTATCTAAGAAACGTATTAGAAAAAATTTTGGTAAAATAAATTTGGTGTCTTCGATACCTAATCTTAT
TGAAGTGCAAAAAAATTCTTATAATAAAGAATTTTTGCAGCTAGGAGTGCCTGTAGATTGCCGTGAAAACAAGGGATTGC
AAGGGGTATTAAATTCTATTTTTCCTATTCATGATTTAGATGGAAGTGCAATATTAGAGTTTGTAAGGTATGATTTTGAT
GAGCCTAAATATGATGTTGAGGAATGTATTCAAAGGGGGCTGAGTTATACTGCTGCTTTAAAAATTACTTTAAGTCTTAT
TGTATTAGATGATAGTGATAAAAGCGATCCTAAAGAAATCAAGGGTATAAAAGAGCAAGCAGTTTATTTTGGAGATATTC
CATTAATGACTGCTAATGGTACTTTTGTTATTAATGGTACTGAGAGAGTAGTAGTATCACAGATGCATAGATCTCCAGGA
GTTTTCTTTGATCACGATGATGGAAAAACACATTCTACTGGTAAATTAATATATTCAGCAAGAGTTATTCCTTATCGTGG
TTCATGGTTAGATTTTGAATTTGATGCTAAAGATTTATTATATTTTAGAATTGATCGTAAACGAAAGCTTTATGTTACCA
CTTTGCTTATGGCTTTAGGTATGTCATCACATGACATACTAAATTTTTATTATGAATCTGCAACTTATAAAAAATATAAA
AAAAGTGAGAATGGGTGGATTGTTGACTTTTTACCTGAATTAGTTAGTACTAAGCATTTAGCTTATGATTTAATTGATGC
GCAGACTGGTAAGGTATTATTAAATGCAGGTCAAAAGATTACGTTTAGGATAGCAAAAATGCTTGCTGATAAAGGAGTCA
AGCAAATCTTAGTTAAGAATGATAGTTTGGTTGGGAAATTGTTAGCTGAAGATTTAGTTAATAATCAAACTGGTGAAGTA
TTATTAGGTGTAGGAGAAGAAATTACTAATGATATCTTAACAATAGTAAATGATTTGCAAATTACGACTGTTAAGGTTTT
AGCAGTAGGTGGGCAATGTGGTCCATATGTGCGTAATACTTTGTTTCTAGATAAAAATAAGGATCAAAAATCATCATTGG
TGGAGATATTTCGAGTATTGAAGCCTGGTGAAATGGCTACAACTGCAGCTAGTCGTGGATTACTTGATAGTTTACTGTTT
GATAATAATAGATATGATCTTTCTGAAGTTGGAAGAATTAAGATTAACTCTAGGTTAAATCTGGATATAGACTTAAAAAA
TACCTGTATAACTGTAGAGGATATAAAAAAGATAATTAAGCTCTTGGTTGATATCAAAGATGGTAAAGCTTTAGTAGATG
ATATTGATCATTTAGGTAATCGTAGAGTTAGGTCAGTAGGTGAGTTAGTTGAAAACCAATTTAGAACTGGGTTGGTTAGA
ATTGCAAAATTTATTGTAGAGAGAATAGGCAGTGTTGAGATTGATGCTGTTGTGCCTAACGATTTAGTTAATGCTAAATT
ATTGACATCTGTAATAAAAGAATTTTTTGGGACTTCTCAATTATCTCAGTTTATGGATCAGACAAATGCTTTATCGCAGA
TAACTCATATAAGAAGATTATCTGCGCTTGGCCCAGGTGGATTGAATCGTGATAGAGCTGCTTTAGAAGTTAGGGATGTA
CATCCAACTCATTATGGTCGTATTTGTCCGATTGAAACTCCAGAAGGTCAAAATATTGGATTAATTAATTCTTTAGCTAT
TTTTGCTAAAATTAATAGGTATGGATTTATAGAAAGTCCTTATCGCAGGGTTATCAATAGGCGTGTTACAGATGAAGTAG
TATATCTTTCTGCGCTTGAGGAAGGAAGATATAAAATAGCTCAAGCTGATACTTCTTTATGTACTAATGACTGTCTTATT
GATGGATTAGTTAGTTGTCGCTATGATGGTAATTTTGTTATGGTACTTGCTCAAGAAGTAGATTTTATTGATTTAACTCC
TATGCAAGTTGTATCAGTTGCTGCTTCTATGATCCCATTTCTAGAAAATGATGATGCTAATCGTGCGTTGATGGGAGCTA
ATATGCAAAGGCAGGCTGTGCCATTGTTAAAGAGTCAAGCTCCTTTAGTTGGGACTGGAATTGAATCTGTTGTTGCTCAT
GATTCTGGGACAGTTGTTGCTGCTTTACATGATGGAATTGTGGAACAAGTAGATTCGACTAGAATAGTTGTTAAAACTTC
AGTTAAAAAGGATGCTGGAGCTCCTGGTGTTGATATATATAATCTTAAAAAATTTCAGAGATCAAACTATAATACTTGTA
TTAATCAAAAGGTATTAGTAAATGTTGGAGACATAGTAAAAAAAGGTGATGTTATTGCTGATGGTGTAGCTACTAATAAA
GGAGAGATAGCTTTAGGGCGTAATGTTTTAGTAGCATTTATTGCCTGGAATGGGTATACTTTTGAGGATTCTATATTAGT
TTCTGAAAGAATTGTTAAAGAGGATATATACACATCAATTCATATTGAAGAGTTAGAGCTTGTTGCTAGAGATACGCGTT
TAGGTCCTGAAGAAATTACTAGAGATATTCCTAATGTTAATGACGAAAGTTTGCGTCATTTAGATGAGGTTGGTATTGTA
AATATTGGAGCTAAAGTACGAACTGGTGATATTTTAGTTGGCAAGGTAACACCAAAAAGTGAGTCACCAGTGACTCCAGA
GGAGAAGTTATTAAGAGCTATATTTGGTGAAAAAGCTTCTGAAGTAAAGGATTCATCACTGTATGTTCCTCCTGGAATTA
CTGGAACTGTAATTGATGTACGAGTTTTTTCACGTCGTGGTATAGACAAAGATGAGAGAACTTTAGCAATTGAGAAGCAA
AAGATTAGAAAATTAGTCAAAGATTATGAGGATGAGTTAGCAGTTATTCAACATTTTACTATTGTTAGGGTAAAGGAGCT
ATTAGTAGGGCAAGTGGCTGCTTGTAGTTTAGATAGCATTATAATTGGAGATAAGCTTGATGAAGCTATGCTGAATAAGT
TAACTAACGAGCAATTATTGAAATTGAAAGCAGATAATAGCAGTATCATGGATGAGATTTCAGAAATCAAGTGTCATTAT
GAAACTACTCGTGCTCAATTAACGAGTCAGCTTAATAGTAAAATAGAGAAAATTCAATGTGGTGATGATTTACCTCAAGG
AGCTTTAAGGGTTGTTAAAGTTTTCATTGCTATTAAGCATAGGTTACAGCCTGGAGATAAGATGGCCGGGCGGCATGGTA
ATAAAGGTGTAGTTTCTAAAGTAGTGCCTGAGGAAGATATGCCATTTCTTGAAGATGGTACTGTTGTTGATATAGTATTA
AATCCGTTGGGGTTACCTGCTAGAATGAATGTTGGACAAATCTTAGAGACTCATTTAGGTTGGGCTGGAGTGAATTTAGG
ACGGAAGATTGGAAAGATGGTTGATGATTATTATTCTGGTAATAATCAATGTACTGATGAAATTAGAAAATTTGTAAAAA
AGATATATGCAAATAATAGTATTGCTGATACTATTGATCAAGTAAATGATCAACAATTAATTGAGATATGTCAAGAGTTG
CGTCAAGGAATATATTTTTCGACTCCAGTATTTGATGGAGCAAAAATTGCAGATATAAAGCAAATGCTTGAGTTAGCTGA
TGTAGATAAGTCTGGACAAGTGAGGCTTATTGATGGTAGGACTGGAGAATATTTTGATAGAAGATGTACTGTAGGTTATC
AATATTTATTGAAGTTGCATCATTTGGTTGATGAAAAAATACATGCTCGTTCTATTGGACCATATAGTCTCGTAACACAG
CAACCTTTAGGAGGTAAATCTCACTTTGGAGGGCAAAGATTTGGAGAAATGGAGTGTTGGGCACTAGAAGCATATGGTGC
GGCTTATACACTTCAGGAGCTTTTGACAACTAAATCTGATTCTGTAGAAGGTAGAATTAAAATGTATCAAGCAATAATAC
GTGGTAATAATAATTTTGTGTCTGGTGTTCCTGAATCGTTAAATGTTATGATTAAAGAATTAAGGTCTCTATGTCTCAAT
ATTCAGTTAGAGGAGAATGATGAAGAAGATGAGAATGAGGATGAAAATTATTAA

Protein sequence :
MQYLLSKKRIRKNFGKINLVSSIPNLIEVQKNSYNKEFLQLGVPVDCRENKGLQGVLNSIFPIHDLDGSAILEFVRYDFD
EPKYDVEECIQRGLSYTAALKITLSLIVLDDSDKSDPKEIKGIKEQAVYFGDIPLMTANGTFVINGTERVVVSQMHRSPG
VFFDHDDGKTHSTGKLIYSARVIPYRGSWLDFEFDAKDLLYFRIDRKRKLYVTTLLMALGMSSHDILNFYYESATYKKYK
KSENGWIVDFLPELVSTKHLAYDLIDAQTGKVLLNAGQKITFRIAKMLADKGVKQILVKNDSLVGKLLAEDLVNNQTGEV
LLGVGEEITNDILTIVNDLQITTVKVLAVGGQCGPYVRNTLFLDKNKDQKSSLVEIFRVLKPGEMATTAASRGLLDSLLF
DNNRYDLSEVGRIKINSRLNLDIDLKNTCITVEDIKKIIKLLVDIKDGKALVDDIDHLGNRRVRSVGELVENQFRTGLVR
IAKFIVERIGSVEIDAVVPNDLVNAKLLTSVIKEFFGTSQLSQFMDQTNALSQITHIRRLSALGPGGLNRDRAALEVRDV
HPTHYGRICPIETPEGQNIGLINSLAIFAKINRYGFIESPYRRVINRRVTDEVVYLSALEEGRYKIAQADTSLCTNDCLI
DGLVSCRYDGNFVMVLAQEVDFIDLTPMQVVSVAASMIPFLENDDANRALMGANMQRQAVPLLKSQAPLVGTGIESVVAH
DSGTVVAALHDGIVEQVDSTRIVVKTSVKKDAGAPGVDIYNLKKFQRSNYNTCINQKVLVNVGDIVKKGDVIADGVATNK
GEIALGRNVLVAFIAWNGYTFEDSILVSERIVKEDIYTSIHIEELELVARDTRLGPEEITRDIPNVNDESLRHLDEVGIV
NIGAKVRTGDILVGKVTPKSESPVTPEEKLLRAIFGEKASEVKDSSLYVPPGITGTVIDVRVFSRRGIDKDERTLAIEKQ
KIRKLVKDYEDELAVIQHFTIVRVKELLVGQVAACSLDSIIIGDKLDEAMLNKLTNEQLLKLKADNSSIMDEISEIKCHY
ETTRAQLTSQLNSKIEKIQCGDDLPQGALRVVKVFIAIKHRLQPGDKMAGRHGNKGVVSKVVPEEDMPFLEDGTVVDIVL
NPLGLPARMNVGQILETHLGWAGVNLGRKIGKMVDDYYSGNNQCTDEIRKFVKKIYANNSIADTIDQVNDQQLIEICQEL
RQGIYFSTPVFDGAKIADIKQMLELADVDKSGQVRLIDGRTGEYFDRRCTVGYQYLLKLHHLVDEKIHARSIGPYSLVTQ
QPLGGKSHFGGQRFGEMECWALEAYGAAYTLQELLTTKSDSVEGRIKMYQAIIRGNNNFVSGVPESLNVMIKELRSLCLN
IQLEENDEEDENEDENY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00346 YP_008207811.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR25 Protein 0.0 54
BJAB0868_00350 YP_008211676.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR26 Protein 0.0 54

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_009085.4918494.p0 Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_010400.5987325.p0 Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_010611.6233925.p0 Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_011595.7060572.p0 Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_010410.6003841.p0 Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_011586.7046027.p0 Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_002516.2.881699.p Protein 0.0 54
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_008702.1.4609796. Protein 0.0 53
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP002695.1.gene18.p0 Protein 0.0 53
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP000675.2.gene392.p Protein 0.0 53
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_002695.1.914942.p Protein 0.0 52
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP001918.1.gene250.p Protein 0.0 52
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP000034.1.gene3741. Protein 0.0 52
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP001138.1.gene4362. Protein 0.0 52
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP004022.1.gene2794. Protein 0.0 52
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta CP000647.1.gene4402. Protein 0.0 52
rpoB YP_001248196.1 DNA-directed RNA polymerase subunit beta NC_011035.1.6448762. Protein 0.0 52