Gene Information

Name : rpoB (Mext_4017)
Accession : YP_001641458.1
Strain : Methylobacterium extorquens PA1
Genome accession: NC_010172
Putative virulence/resistance : Unknown
Product : DNA-directed RNA polymerase subunit beta
Function : -
COG functional category : K : Transcription
COG ID : COG0085
EC number : -
Position : 4460587 - 4464717 bp
Length : 4131 bp
Strand : +
Note : DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme

DNA sequence :
ATGGCCAATACGCTGGTCGGTCGCAAGCGCATTCGCAAGTTCTTCGGTAAGATCCGGGAAGTCGCCGAGATGCCGAACCT
CATCGAGGTTCAAAAGGCGTCCTACGACCAGTTCCTGATGGTGGACGAGCCCGAGGGCGGGCGTGCCGACGAGGGCCTGC
AGAGCGTCTTCAAGTCGGTCTTCCCGATCTCCGACTTCGCCTCGACGGCGCTGCTCGAGTTCGTGCGGTACACCTTCGAA
CAGCCGAAATACGACGTCGACGAGTGCCGCCAGCGCGGCATCACCTTCGCGGCCCCGCTCAAGGTGACGCTGCGGCTCAT
CGTGTTCGATGTGGACCCCGATACCGGCGCCAAGTCGGTCAAGGACATCAAGGAGCAGGATGTCTACATGGGCGACATGC
CGCTCATGACGGACAACGGCACCTTCATCGTCAACGGCACCGAGCGCGTCATCGTCTCGCAGATGCACCGCTCGCCGGGC
GTGTTCTTCGACCACGACAAGGGCAAGACCCACTCGTCCGGCAAGCTGCTGTTCGCCGCCCGCATCATCCCCTACCGGGG
CTCCTGGCTCGACGTCGAGTTCGACGCCAAGGACATCGTGCACGTGCGTATCGACCGCAAGCGCAAGCTGCCGGTCACCT
CGCTGCTGTTCGCGCTCGGCCTCGACGGCGAAGAGATCCTCTCGACCTTCTACAACCGCGTCGCCTACCAGCGTGACGGG
GCGGATTGGCGCGTGCCGTTCGACGCCGAGCGCCTCAAGGGATTCAAGGCCTCGGTCGATCTCATCGACGCCGATTCCGG
CGAGGTCGTGCTGGAGGCGGGCAAGAAGCTCAACGCCCGCAACGCGCGTCTGATCGGCGAGAAGGGCACCAAGTTCCTGC
GCGCCGCGGACGAGGATCTGATCGGCCAGTACATCGCCGAAGACCTCGTCAACATGAAGACGGGCGAGATCTGGGCCGAG
GCCGGCGACGAGATCTCCGAGAAGCTCCTCAAGAGCCTCGACGACGTCGGCGTCACCGAGCTGCCCGTGCTCGACATCGA
CCACGTCAATGTCGGCCCCTACATCCGCAACACGCTGGCGGTGGACAAGAACTCCGCCCGCGAGGGCGCGCTGTTCGACA
TCTACCGCGTCATGCGCCCCGGCGAGCCGCCGACGCTCGACACCGCTGAGGCGATGTTCCACTCGCTGTTCTTCGATTCC
GAGCGCTACGACCTCTCGGCGGTCGGCCGCGTGAAGATGAACATGCGCCTCGACCTCGACGCCGCCGACACCGTGCGGAC
GCTGCGTCGCGAGGACATGCTCGCGGTCGTCAAGGCGCTGGTCGACCTGCGCGACGGCAAGGGCGAGATCGACGACATCG
ACCACCTCGGCAACCGCCGTGTCCGCTCGGTCGGCGAGCTGATGGAGAACCAGTACCGTCTGGGCCTCCTGCGGATGGAG
CGCGCCATCAAGGAGCGCATGTCCTCGGTCGATATCGACACGGTGATGCCGCAGGATCTCATCAACGCGAAGCCCGCCGC
GGCCGCGGTGCGCGAGTTCTTCGGCTCGTCGCAGCTCTCGCAGTTCATGGACCAGACCAACCCGCTGTCGGAAGTGACGC
ACAAGCGCCGCCTCTCGGCGCTTGGCCCGGGCGGTCTGACCCGCGAGCGCGCCGGCTTCGAGGTGCGCGACGTGCACCCG
ACCCATTACGGCCGCATCTGCCCGATCGAGACCCCGGAAGGCCCGAACATCGGCCTGATCAACTCGCTGGCGACCTTCGC
CCGCGTGAACAAGTACGGCTTCATCGAGACGCCGTTCCGCCGGGTGAAGGACGGCGTGGTGACCGACGAGGTCGCCTACC
TCTCCGCCATGGAAGAGGCGAAGTACTACGTCGCCCAGGCCAATGCCGGCATGGACGAGGGCCGCAAGCTGACGGACGAC
CTCGTGGTCTGCCGCCGCGCGGGTGAGGTCATCGTGGTCGCCCCCGACCGCGTCGATCTTATGGACGTGTCGCCGAAGCA
GCTCGTCTCGGTCGCCGCGGCGCTGATCCCGTTCCTCGAGAACGACGACGCCAACCGCGCGCTGATGGGCTCGAACATGC
AGCGCCAGGCGGTGCCGCTGGTTCGCGCCGACGCGCCCTTCGTCGGCACCGGCATGGAGGCCGTGGTCGCCCGCGACTCG
GGTGCCGCCATCGCCGCCCGTCGCTCCGGCATCGTCGATCAGGTGGACGCCACCCGTATCGTCATCCGCGCCTCGGAAGA
GACCGACCCGACCAAGCCCGGCGTCGACATCTACCGCCTGCAGAAGTTCCAGCGCTCCAACCAGTCGACCTGCATCACGC
AGAAGCCGCTGGTGCGCGTCGGCGAGCCGGTGAAGAAGGGCGAGATCATCGCCGACGGTCCCTCGACCGAGTTCGGTGAG
CTCGCGCTCGGCCGCAACGTGCTCGTCGCGTTCATGCCGTGGAACGGCTACAACTTCGAGGACTCGATCCTGCTCTCCGA
GCGGATCGTGAAGGATGACGTGTTCACCTCGATCCACATCGAGGAATTCGAGGTGATGGCCCGCGACACCAAGCTGGGTC
CGGAGGAGATCACCCGCGACATCCCGAACGTCTCGGAAGAGGCGCTCAAGAACCTCGACGAGGCCGGCATCGTCTATATC
GGCGCCGAGGTGCATGCCGGCGACATCCTCGTCGGCAAGATCACGCCGAAGGGTGAGAGCCCGATGACGCCGGAGGAGAA
GCTCCTGCGCGCCATCTTCGGCGAGAAGGCCTCGGACGTGCGCGACACCTCGCTCCGGGTTCCCCCGGGCGTGACCGGCA
CGATCGTCGAGGTGCGGGTGTTCAACCGCCACGGCGTCGACAAGGACGAGCGCGCCCAGGCGATCGAGCGTGAGGAGATC
GAGCGTCTCGCCAAGGACCGCGACGACGAGCAGACCATCCTCGACCGCAACACCTATGCCCGCTTGGCCGAGGTGCTGAT
CGGTCAGTCGCCGATCGCCGGCCCGAAGGGCTTCCGCAAGGACACCACGCTGACCCGCGAGATCATCAGCGAGTATCCCC
GCTCGCAATGGTGGCAGTTTGCCGTCGTCGACGACCGTATGATGACGGAAATCGAGGCGATGCAGAAGCAGTACGACGAG
TCGAAGAAGCGCCTCGAGCAGCGCTTCCTCGACAAGGTCGAGAAGCTGCAGCGCGGCGACGAGCTTCCGCCCGGCGTCAT
GAAGATGGTCAAGGTCTTCGTGGCGGTGAAGCGCAAGATCCAGCCCGGCGACAAGATGGCCGGCCGCCACGGCAACAAGG
GTGTCGTGTCGCGCATCGTGCCGATCGAGGACATGCCGTTCCTCGAAGACGGCACGCATGCCGACATCGTGCTCAACCCG
CTCGGCGTGCCCTCGCGCATGAATGTCGGCCAGATCCTGGAAACCCATCTGGGCTGGGCGGCTGCGGGCTTGGGTCGCAA
GGTCTCCAAGGCGGTCGATGCCTATCTGAAGAACCAGGATATCGCGCCGCTGCGGGCTGAGATGGAAGCGATCTACTCGC
CGTCCGAACTCGAGGGGCTGTCCGACGAGGCTCTGGCCGAGGCGGGCAACAACGTGCGCCGCGGCGTGCCGATGGCCACC
CCGGTGTTCAACGGCGCCAAGGAAGCCGACATCGAGACGATGCTGGAGATGGCCGGGCTCGACCGCTCGGCGCAGTCGAC
GCTCTACGACGGGCGCACCGGCGAGCCCTTCGACCGCAAGGTCACCATGGGCTACATCTACATGCTGAAGCTGCACCACC
TCGTGGACGACAAGATCCACGCGCGCTCGATCGGCCCGTACTCGCTCGTCACCCAGCAGCCGCTGGGCGGTAAGGCGCAG
TTCGGCGGTCAGCGCTTCGGTGAGATGGAGGTCTGGGCGCTGGAGGCCTACGGCGCGGCCTACACGCTGCAGGAGATGCT
CACGGTGAAGTCGGACGACGTGGCCGGCCGCACCAAGGTCTACGAGGCGATCGTCCGCGGCGACGACACGTTCGAGGCTG
GCATCCCCGAGTCCTTCAACGTGCTCGTCAAGGAGATGCGCTCGCTCGGCCTCAACGTCGAGCTCACCTCCTCCAAGCAG
CAGCAGGCGGCCAACGACCAGATCGAGCCGCCGGCCGACGCCGCCGAGTAA

Protein sequence :
MANTLVGRKRIRKFFGKIREVAEMPNLIEVQKASYDQFLMVDEPEGGRADEGLQSVFKSVFPISDFASTALLEFVRYTFE
QPKYDVDECRQRGITFAAPLKVTLRLIVFDVDPDTGAKSVKDIKEQDVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPG
VFFDHDKGKTHSSGKLLFAARIIPYRGSWLDVEFDAKDIVHVRIDRKRKLPVTSLLFALGLDGEEILSTFYNRVAYQRDG
ADWRVPFDAERLKGFKASVDLIDADSGEVVLEAGKKLNARNARLIGEKGTKFLRAADEDLIGQYIAEDLVNMKTGEIWAE
AGDEISEKLLKSLDDVGVTELPVLDIDHVNVGPYIRNTLAVDKNSAREGALFDIYRVMRPGEPPTLDTAEAMFHSLFFDS
ERYDLSAVGRVKMNMRLDLDAADTVRTLRREDMLAVVKALVDLRDGKGEIDDIDHLGNRRVRSVGELMENQYRLGLLRME
RAIKERMSSVDIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHP
THYGRICPIETPEGPNIGLINSLATFARVNKYGFIETPFRRVKDGVVTDEVAYLSAMEEAKYYVAQANAGMDEGRKLTDD
LVVCRRAGEVIVVAPDRVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRADAPFVGTGMEAVVARDS
GAAIAARRSGIVDQVDATRIVIRASEETDPTKPGVDIYRLQKFQRSNQSTCITQKPLVRVGEPVKKGEIIADGPSTEFGE
LALGRNVLVAFMPWNGYNFEDSILLSERIVKDDVFTSIHIEEFEVMARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYI
GAEVHAGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSLRVPPGVTGTIVEVRVFNRHGVDKDERAQAIEREEI
ERLAKDRDDEQTILDRNTYARLAEVLIGQSPIAGPKGFRKDTTLTREIISEYPRSQWWQFAVVDDRMMTEIEAMQKQYDE
SKKRLEQRFLDKVEKLQRGDELPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRIVPIEDMPFLEDGTHADIVLNP
LGVPSRMNVGQILETHLGWAAAGLGRKVSKAVDAYLKNQDIAPLRAEMEAIYSPSELEGLSDEALAEAGNNVRRGVPMAT
PVFNGAKEADIETMLEMAGLDRSAQSTLYDGRTGEPFDRKVTMGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQ
FGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLNVELTSSKQ
QQAANDQIEPPADAAE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00346 YP_008207811.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR25 Protein 0.0 58
BJAB0868_00350 YP_008211676.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR26 Protein 0.0 58

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_002516.2.881699.p Protein 0.0 60
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP000034.1.gene3741. Protein 0.0 59
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP001918.1.gene250.p Protein 0.0 59
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP001138.1.gene4362. Protein 0.0 59
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_002695.1.914942.p Protein 0.0 59
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP000675.2.gene392.p Protein 0.0 59
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_009085.4918494.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_011595.7060572.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_010410.6003841.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_011586.7046027.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_010400.5987325.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_010611.6233925.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP000647.1.gene4402. Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_008702.1.4609796. Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP002695.1.gene18.p0 Protein 0.0 58
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta CP004022.1.gene2794. Protein 0.0 57
rpoB YP_001641458.1 DNA-directed RNA polymerase subunit beta NC_011035.1.6448762. Protein 0.0 57