Gene Information

Name : rpoB (Mchl_4386)
Accession : YP_002423090.1
Strain : Methylobacterium chloromethanicum CM4
Genome accession: NC_011757
Putative virulence/resistance : Unknown
Product : DNA-directed RNA polymerase subunit beta
Function : -
COG functional category : K : Transcription
COG ID : COG0085
EC number : -
Position : 4630736 - 4634866 bp
Length : 4131 bp
Strand : +
Note : DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; subunit beta is part of the catalytic core which binds with a sigma factor to produce the holoenzyme

DNA sequence :
ATGGCCAATACGCTGGTCGGTCGCAAGCGCATTCGCAAGTTCTTCGGTAAGATCCGGGAAGTCGCCGAGATGCCGAACCT
CATCGAGGTTCAAAAGGCGTCCTACGACCAGTTCCTGATGGTGGACGAGCCCGAGGGCGGGCGTGCCGACGAGGGCCTGC
AGAGCGTCTTCAAGTCGGTCTTCCCGATCTCCGACTTCGCCTCGACGGCGCTGCTCGAGTTCGTGCGGTACACCTTCGAA
CAGCCGAAATACGACGTCGACGAGTGCCGCCAGCGCGGCATCACCTTCGCGGCCCCGCTCAAGGTGACGCTGCGGCTCAT
CGTGTTCGATGTGGACCCCGATACCGGCGCCAAGTCGGTCAAGGACATCAAGGAGCAGGATGTCTACATGGGCGACATGC
CGCTCATGACGGACAACGGTACCTTCATCGTCAACGGCACCGAGCGCGTCATCGTCTCGCAGATGCACCGCTCGCCGGGC
GTGTTCTTCGACCACGACAAGGGCAAGACCCACTCGTCCGGCAAGCTGCTGTTCGCCGCCCGCATCATCCCCTACCGGGG
CTCCTGGCTCGACGTCGAATTCGACGCCAAGGACATCGTGCACGTGCGCATCGACCGCAAGCGCAAGCTGCCGGTCACCT
CGCTGCTGTTCGCGCTCGGCCTCGACGGCGAAGAGATCCTCTCGACCTTCTACAACCGCGTCGCCTACCAGCGTGACGGG
GCGGATTGGCGCGTGCCGTTCGACGCCGAGCGCCTCAAGGGCTTCAAGGCTTCGGTCGATCTCATCGACGCCGATTCCGG
CGAGGTCGTGCTGGAGGCGGGCAAGAAGCTCAACGCCCGCAACGCGCGTCTGATCGGCGAGAAGGGCACCAAGTTCCTGC
GCGCCGCCGACGAGGATCTGATCGGCCAGTACATCGCCGAAGACCTCGTCAACATGAAGACGGGCGAGATCTGGGCCGAG
GCCGGCGACGAGATCTCCGAGAAGCTCCTCAAGAGCCTCGACGACGTCGGCGTCACCGAGCTGCCCGTGCTCGACATCGA
CCACGTCAATGTCGGCCCCTACATCCGCAATACGCTAGCTGTGGACAAGAACTCCGCCCGTGAAGGCGCGCTGTTCGACA
TCTACCGCGTGATGCGTCCCGGTGAGCCGCCGACGCTCGACACCGCCGAGGCGATGTTCCACTCGCTGTTCTTCGATTCC
GAGCGCTACGACCTCTCGGCGGTCGGCCGCGTGAAGATGAACATGCGCCTCGACCTCGACGCCGCCGACACCGTGCGGAC
GCTGCGCCGCGAGGACATGCTCGCGGTCGTCAAGGCGCTGGTCGACCTGCGCGACGGCAAGGGCGAGATCGACGACATCG
ACCACCTCGGCAACCGCCGTGTCCGCTCGGTCGGCGAGCTGATGGAGAACCAGTACCGTCTGGGCCTCCTGCGGATGGAG
CGCGCCATCAAGGAGCGCATGTCCTCGGTCGATATCGACACGGTGATGCCGCAGGATCTCATCAACGCGAAGCCCGCCGC
GGCGGCGGTGCGCGAGTTCTTCGGCTCGTCGCAGCTCTCGCAGTTCATGGACCAGACCAACCCGCTGTCGGAAGTGACGC
ACAAGCGCCGCCTCTCGGCGCTTGGCCCGGGCGGTCTGACCCGCGAGCGCGCCGGCTTCGAGGTGCGCGACGTGCACCCG
ACCCATTACGGCCGCATCTGCCCGATCGAGACCCCGGAAGGCCCGAATATCGGCCTGATCAACTCGCTGGCGACCTTCGC
CCGCGTGAACAAGTACGGCTTCATCGAGACGCCGTTCCGCCGGGTGAAGGACGGCGTGGTGACCGACGAGGTCGCCTACC
TCTCCGCCATGGAAGAGGCGAAGTACTACGTCGCCCAGGCCAATGCCGGCATGGACGAGGGCCGTAAGCTGACGGACGAC
CTCGTGGTCTGCCGCCGCGCGGGTGAGGTCATCGTGGTCGCCCCCGACCGCGTCGATCTCATGGACGTGTCGCCGAAGCA
GCTCGTCTCGGTCGCCGCGGCGCTGATCCCGTTCCTCGAGAACGACGACGCCAACCGCGCGCTGATGGGCTCGAACATGC
AGCGCCAGGCGGTGCCGCTGGTTCGCGCCGATGCGCCCTTCGTTGGCACGGGTATGGAGGCCGTGGTCGCCCGCGACTCC
GGTGCTGCCATCGCTGCCCGCCGCTCCGGCATCGTCGATCAGGTGGACGCCACCCGTATCGTCATCCGCGCCTCGGAAGA
GACCGACCCGACCAAGCCCGGCGTCGACATCTACCGCCTGCAGAAGTTCCAGCGCTCCAACCAGTCGACCTGCATCACGC
AGAAGCCGCTGGTGCGCGTCGGCGAGCCGGTGAAGAAGGGCGAGATCATCGCCGACGGTCCCTCGACCGAGTTCGGTGAG
CTCGCGCTCGGCCGCAACGTGCTCGTCGCGTTCATGCCGTGGAACGGCTACAACTTCGAGGACTCGATCCTGCTCTCCGA
GCGGATCGTGAAGGATGACGTGTTCACCTCGATCCACATCGAGGAATTCGAGGTGATGGCCCGCGACACCAAGCTGGGTC
CGGAGGAGATCACCCGCGACATCCCGAACGTCTCGGAAGAGGCGCTCAAGAACCTCGACGAGGCCGGCATCGTCTATATC
GGCGCCGAGGTGCATGCCGGCGACATCCTCGTCGGCAAGATCACGCCGAAGGGCGAGAGCCCGATGACGCCGGAGGAGAA
GCTCCTGCGCGCCATCTTCGGCGAGAAGGCCTCGGACGTGCGCGACACCTCGCTCCGGGTTCCCCCGGGCGTGACCGGCA
CGATCGTCGAGGTGCGGGTGTTCAACCGCCACGGCGTCGACAAGGACGAGCGCGCCCAGGCGATCGAGCGCGAGGAGATC
GAGCGTCTCGCCAAGGACCGCGACGACGAGCAGACCATCCTCGACCGCAACACCTACGCCCGCTTGGCCGAGGTGCTGAT
CGGTCAGTCGCCGATCGCCGGCCCGAAGGGCTTCCGCAAGGACACCACGCTGACCCGCGAGATCATCAGCGAGTATCCCC
GCTCGCAATGGTGGCAGTTCGCCGTCGTCGACGACCGTATGATGACGGAAATCGAGGCGATGCAGAAGCAGTACGACGAG
TCGAAGAAGCGCCTTGAGCAGCGCTTCCTCGACAAGGTCGAGAAGCTGCAGCGCGGCGACGAGCTTCCGCCCGGCGTCAT
GAAGATGGTCAAGGTCTTCGTGGCGGTGAAGCGCAAGATCCAGCCCGGCGACAAGATGGCCGGCCGCCACGGCAACAAGG
GTGTCGTGTCGCGCATCGTGCCGATCGAGGACATGCCGTTCCTCGAAGACGGCACGCATGCCGACATCGTGCTCAACCCG
CTCGGCGTGCCCTCGCGCATGAATGTCGGCCAGATCCTGGAAACCCATCTGGGCTGGGCGGCTGCGGGCTTGGGTCGCAA
GGTCTCCAAGGCGGTCGATGCCTATCTGAAGAACCAGGATATCGCGCCGCTGCGGGCTGAGATGGAAGCGATCTACTCGC
CGTCCGAACTCGAGGGGCTGTCCGACGAGGCTCTGGCCGAGGCGGGCAACAACGTACGCCGCGGCGTGCCGATGGCCACT
CCGGTGTTCAACGGCGCCAAGGAAGCCGACATCGAGACGATGCTGGAGATGGCCGGGCTCGACCGCTCGGCGCAGTCGAC
GCTCTACGACGGGCGGACCGGCGAGCCCTTCGACCGCAAGGTCACCATGGGCTACATCTACATGCTGAAGCTGCACCACC
TCGTGGACGACAAGATCCACGCGCGCTCGATCGGCCCGTACTCGCTCGTCACCCAGCAGCCGCTGGGCGGTAAGGCGCAG
TTCGGCGGTCAGCGCTTCGGTGAGATGGAGGTCTGGGCGCTGGAGGCCTATGGCGCGGCCTACACGCTGCAGGAGATGCT
TACGGTGAAGTCGGACGACGTGGCCGGCCGCACCAAGGTCTACGAGGCGATCGTCCGCGGCGACGACACGTTCGAGGCCG
GCATCCCCGAATCCTTCAACGTGCTCGTCAAGGAGATGCGTTCGCTCGGCCTCAACGTCGAGCTCACCTCCTCCAAGCAG
CAGCAGGCGGCCAACGACCAGATCGAGCCGCCGGCCGACGCCGCCGAGTAA

Protein sequence :
MANTLVGRKRIRKFFGKIREVAEMPNLIEVQKASYDQFLMVDEPEGGRADEGLQSVFKSVFPISDFASTALLEFVRYTFE
QPKYDVDECRQRGITFAAPLKVTLRLIVFDVDPDTGAKSVKDIKEQDVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPG
VFFDHDKGKTHSSGKLLFAARIIPYRGSWLDVEFDAKDIVHVRIDRKRKLPVTSLLFALGLDGEEILSTFYNRVAYQRDG
ADWRVPFDAERLKGFKASVDLIDADSGEVVLEAGKKLNARNARLIGEKGTKFLRAADEDLIGQYIAEDLVNMKTGEIWAE
AGDEISEKLLKSLDDVGVTELPVLDIDHVNVGPYIRNTLAVDKNSAREGALFDIYRVMRPGEPPTLDTAEAMFHSLFFDS
ERYDLSAVGRVKMNMRLDLDAADTVRTLRREDMLAVVKALVDLRDGKGEIDDIDHLGNRRVRSVGELMENQYRLGLLRME
RAIKERMSSVDIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHP
THYGRICPIETPEGPNIGLINSLATFARVNKYGFIETPFRRVKDGVVTDEVAYLSAMEEAKYYVAQANAGMDEGRKLTDD
LVVCRRAGEVIVVAPDRVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRADAPFVGTGMEAVVARDS
GAAIAARRSGIVDQVDATRIVIRASEETDPTKPGVDIYRLQKFQRSNQSTCITQKPLVRVGEPVKKGEIIADGPSTEFGE
LALGRNVLVAFMPWNGYNFEDSILLSERIVKDDVFTSIHIEEFEVMARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYI
GAEVHAGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSLRVPPGVTGTIVEVRVFNRHGVDKDERAQAIEREEI
ERLAKDRDDEQTILDRNTYARLAEVLIGQSPIAGPKGFRKDTTLTREIISEYPRSQWWQFAVVDDRMMTEIEAMQKQYDE
SKKRLEQRFLDKVEKLQRGDELPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRIVPIEDMPFLEDGTHADIVLNP
LGVPSRMNVGQILETHLGWAAAGLGRKVSKAVDAYLKNQDIAPLRAEMEAIYSPSELEGLSDEALAEAGNNVRRGVPMAT
PVFNGAKEADIETMLEMAGLDRSAQSTLYDGRTGEPFDRKVTMGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQ
FGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLNVELTSSKQ
QQAANDQIEPPADAAE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00346 YP_008207811.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR25 Protein 0.0 58
BJAB0868_00350 YP_008211676.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR26 Protein 0.0 58

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_002516.2.881699.p Protein 0.0 60
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP001918.1.gene250.p Protein 0.0 59
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP001138.1.gene4362. Protein 0.0 59
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_002695.1.914942.p Protein 0.0 59
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP000034.1.gene3741. Protein 0.0 59
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP000675.2.gene392.p Protein 0.0 59
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_009085.4918494.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_010410.6003841.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_011586.7046027.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_010400.5987325.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_010611.6233925.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_011595.7060572.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP000647.1.gene4402. Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_008702.1.4609796. Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP002695.1.gene18.p0 Protein 0.0 58
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta CP004022.1.gene2794. Protein 0.0 57
rpoB YP_002423090.1 DNA-directed RNA polymerase subunit beta NC_011035.1.6448762. Protein 0.0 57