Gene Information

Name : rpoB (D11S_0063)
Accession : YP_003254706.1
Strain : Aggregatibacter actinomycetemcomitans D11S-1
Genome accession: NC_013416
Putative virulence/resistance : Unknown
Product : DNA-directed RNA polymerase subunit beta
Function : -
COG functional category : K : Transcription
COG ID : COG0085
EC number : -
Position : 48950 - 52978 bp
Length : 4029 bp
Strand : +
Note : DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme

DNA sequence :
ATGGTTTACTCCTATACCGAGAAAAAACGAATTCGTAAAGACTTCGGCAAACGTCCGCAAGTTTTAAATATTCCCTATTT
ATTAACAATCCAGATCGACTCTTTTGAGAAATTTATTAAAAGAGATCCGGATGGTCAACAAGGCTTAGAAGCCGCTTTCC
GCTCCGTCTTCCCAATTGTCAGTACGAACGGAAATACCGAATTACAATATGTCAGCTATCAATTAGGCGAGCCTGTATTT
GATGTGCGTGAATGTCAAATTCGCGGCACGACCTATGCGGCACCATTGCGTGTAAAATTGCGTTTAGTCAGCTATGACAA
AGACGCAGCACCGGGCACGATCAAAGATATTAAAGAACAAGAAGTTTACATGGGTGAAATCCCGTTGATGACCGATAACG
GTACTTTTGTGATTAACGGTACCGAGCGTGTTATCGTATCTCAATTACACCGCAGTCCGGGTGTATTTTTTGATAGCGAC
AAAGGCAAAACCCACTCTTCAGGTAAAGTGCTTTATAATGCACGCATTATTCCTTACCGTGGTTCATGGTTGGATTTTGA
GTTTGATCCGAAAGATAACTTATACGCACGTATTGACCGCCGTCGTAAATTACCGGCAACCATTATTTTGCGTGCTTTAG
GCTACACCACCGAACAAATCTTAGATCTTTTCTTTTATAAAATTACTTTTGAAATCAAAGATAACAAATTGTTGATGACG
TTAGTGCCGGAACGCCTACGTGGTGAAACCGCCGCCTTTGATATTGAAACCAAAGGCAAGGTGTATGTAGAACGCGGTCG
TCGTATTACCGCCCGTCACATTAAAGCGTTGGAAAAAGATAAAGTCACTCAGGTGGAAGTGCCAACCGAATATATTATCG
GGAAAGTTGCCGCGAAAGATTATGTAGATTTAGAAACCGGCGAATTAATTTGCCCGGCGAATATGGAACTTTCTCTTGAA
TTATTGGCGAAATTGGCACAAGCCGGTTATACCACGCTGGAAACTCTATTTACCAATGACTTGGATTACGGTCCGTATAT
TTCCGAAACCCTGCGTGTTGATCCGTCGAACGATCGTTTAAGCGCTTTGGTGGAAATTTATCGCATGATGCGTCCGGGCG
AACCACCGACAAAAGAAGCGGCGGAAGCGTTATTCGATAATTTATTCTTCTCTTCCGATCGTTATGACTTATCTGCGGTA
GGGCGCATGAAATTCAACCGCTCTTTAGGCATTGAAGAAACCACTGGTGGTGGCACCTTAAGCAATGAAGATATTGTCAG
TGTGATGAAAAAATTGATTGATATCCGTAATGGCCGTGGTGAAGTGGATGATATTGACCACTTGGGTAACCGTCGTATTC
GTTCCGTAGGTGAAATGGCGGAAAATCAATTCCGTATCGGCTTGGTTCGTGTTGAACGCGCGGTAAAAGAACGCTTATCT
TTAGGTGATCTGGAAGCTGTTACCCCGCAAGATCTAATCAATGCGAAACCGATTTCCGCCGCGGTGAAAGAATTCTTTGG
TTCATCCCAATTGTCTCAATTTATGGACCAAAACAACCCGTTATCGGAAGTGACCCATAAACGCCGTATTTCCGCATTGG
GTCCTGGCGGTTTAACCCGTGAGCGTGCCGGTTTTGAAGTGCGTGATGTACACGCCACCCACTACGGTCGTGTGTGTCCG
ATTGAAACCCCTGAAGGTCCGAACATCGGTTTGATCAACTCCCTTTCCGTTTATGCGCGTACTAACGACTACGGTTTCTT
AGAAACTCCGTACCGTAAAGTAGTAAATGGTCAGGTGACCGAAGAAATCGAATATTTGTCTGCCATTGAAGAAGGCAAAT
ACGTTATCGCACAGGCGAACTCCAATCTTGATGATGATTTCCGCTTTACCGATGCCTTTGTAACCTGTCGTGGTGAACAT
GGTGAATCCGGCTTATATAAACCGGAAGAAATTCACTATATGGACGTTTCTACCCAACAAGTGGTTTCCGTAGCGGCGGC
ATTGATTCCGTTCCTGGAGCATGACGATGCGAACCGTGCTTTGATGGGGGCGAACATGCAACGTCAAGCCGTGCCGACAT
TGCGTGCGGACAAACCGTTAGTCGGTACAGGTATCGAAAAAGCGGTTGCCCTTGACTCCGGTGTGGCGGTTGTGGCAAAA
CGCGGCGGTACCGTCCAATATGTGGATGCTTCCCGCATCGTGGTGAAAGTCAATGAAGACGAAACTGTCGCGGGCGAAGC
CGGTATTGATATTTATAACCTCATTAAATATACCCGTTCGAACCAAAATACCTGTATCAACCAAATTCCTTGTGTGGAAC
TGGGCGATCCGGTGGAACGCGGTGAAATCTTGGCAGACGGTCCTTCCACCGATTTAGGTGAATTGGCATTAGGTCAAAAC
ATTCGCGTGGCGTTCATGCCGTGGAACGGTTATAACTTCGAAGACTCCATGTTAGTCTCCGAACGTGTGGTTCAACAAGA
TCGCTTCACCACGATTCACATCCAAGAACTTTCTTGTGTAGCGCGTGATACCAAATTAGGCGCGGAAGAAATTACCGCAG
ATATTCCTAACGTCGGTGAAGCCGCACTAAGTAAGTTGGACGAATCCGGTATCGTGTATATCGGTGCGGAAGTGAAAGGC
GGCGATATTCTGGTAGGTAAAGTGACACCGAAAGGTGAAACCCAATTAACGCCGGAAGAAAAATTATTGCGTGCGATCTT
CGGTGAAAAAGCCTCCGATGTGAAAGACTCCTCTCTACGCGTACCAAACAGCGTTTCCGGTACGGTTATCGATGTGCAAG
TGTTTACCCGCGATGGTGTGGAAAAAGACAAACGTGCGTTAGAAATTGAAGAAATGCAATTAAAACAAGCGAAAAAAGAT
TTGAGCGAAGAGTTTGAGATCTTGGAAGCCGGCTTGTTTATGCGCGTACGCAATCTGTTGTTATCCGGCGGTTTCGATGC
GAAATCCTTGGATAAATTAGACCGCACTAAATGGTTGGAACAAACTTTAGATAACGAAGAAAAACAACACCAATTAGAGC
AGTTGGCGGAACAGCACGAAGAATTACGCAAAGAATTTGAACGTAAATTGGAAATTCAACGCAACAAGATTATCCAAGGC
GACGATTTGGCACCGGGCGTGTTAAAAGTGGTTAAAGTGTATCTTGCGGTGAAACGTCAAATTCAACCGGGTGATAAAAT
GGCGGGTCGTCACGGTAACAAAGGGGTTATCTCCAAAATTAACCCGGTGGAAGACATGCCATACGATGAAAACGGTCAAC
CTGTTGAGATCGTATTGAACCCGCTGGGCGTTCCGTCCCGTATGAATATCGGTCAAATCTTGGAAACTCACTTAGGTTTG
GCGGCGAAAGGTATTGGCGATCAAATTAACGCGATGATTAAACAACAACAATCTATCGCGAAATTGCGTGAATACATGCA
AAAAGCCTATGACCTTGGCGGCGGTTCACAAAAAGTGGATCTCAGCACCTTTACCGATGAAGAAGTGATGCGTTTGGCGC
AAAATCTGCGTAAAGGTTTGCCGGTTGCTACACCGGTATTTGACGGTGCACATGAAAAAGAAATCAAAGGTTTGTTAGAG
CTTGGTGGTTTACCGACTTCCGGTCAAATTACCCTTTATGATGGTCGCACAGGTGAAAAATTCGAGCGTCCGGTAACCGT
AGGTTATATGTATATGCTCAAATTGAATCACTTGGTTGATGACAAAATGCACGCGCGTTCAACCGGTTCTTATAGTCTTG
TTACCCAACAACCGTTGGGCGGTAAGGCGCAGTTCGGTGGTCAACGTTTCGGTGAAATGGAGGTGTGGGCACTTGAGGCT
TATGGTGCGGCTTATACCTTACAAGAAATGTTAACCGTGAAATCCGATGACGTGAACGGTCGTACGAAGATGTATAAAAA
CATCGTCAGCGGCAACCAACAAATGGATCCGGGTACACCGGAATCTTTCAACGTAATCATGAAAGAAATCCGTTCACTTG
GTATCAACATCGACTTGGACGAAGAATAA

Protein sequence :
MVYSYTEKKRIRKDFGKRPQVLNIPYLLTIQIDSFEKFIKRDPDGQQGLEAAFRSVFPIVSTNGNTELQYVSYQLGEPVF
DVRECQIRGTTYAAPLRVKLRLVSYDKDAAPGTIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSD
KGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALGYTTEQILDLFFYKITFEIKDNKLLMT
LVPERLRGETAAFDIETKGKVYVERGRRITARHIKALEKDKVTQVEVPTEYIIGKVAAKDYVDLETGELICPANMELSLE
LLAKLAQAGYTTLETLFTNDLDYGPYISETLRVDPSNDRLSALVEIYRMMRPGEPPTKEAAEALFDNLFFSSDRYDLSAV
GRMKFNRSLGIEETTGGGTLSNEDIVSVMKKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLS
LGDLEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCP
IETPEGPNIGLINSLSVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYVIAQANSNLDDDFRFTDAFVTCRGEH
GESGLYKPEEIHYMDVSTQQVVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGIEKAVALDSGVAVVAK
RGGTVQYVDASRIVVKVNEDETVAGEAGIDIYNLIKYTRSNQNTCINQIPCVELGDPVERGEILADGPSTDLGELALGQN
IRVAFMPWNGYNFEDSMLVSERVVQQDRFTTIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVKG
GDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKD
LSEEFEILEAGLFMRVRNLLLSGGFDAKSLDKLDRTKWLEQTLDNEEKQHQLEQLAEQHEELRKEFERKLEIQRNKIIQG
DDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVEIVLNPLGVPSRMNIGQILETHLGL
AAKGIGDQINAMIKQQQSIAKLREYMQKAYDLGGGSQKVDLSTFTDEEVMRLAQNLRKGLPVATPVFDGAHEKEIKGLLE
LGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEA
YGAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDLDEE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00346 YP_008207811.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR25 Protein 0.0 70
BJAB0868_00350 YP_008211676.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR26 Protein 0.0 70

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP000034.1.gene3741. Protein 0.0 86
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP001918.1.gene250.p Protein 0.0 86
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_002695.1.914942.p Protein 0.0 86
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP001138.1.gene4362. Protein 0.0 85
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP000647.1.gene4402. Protein 0.0 85
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP004022.1.gene2794. Protein 0.0 84
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_009085.4918494.p0 Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_010410.6003841.p0 Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_011586.7046027.p0 Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_010400.5987325.p0 Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_010611.6233925.p0 Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_011595.7060572.p0 Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_002516.2.881699.p Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP000675.2.gene392.p Protein 0.0 70
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_008702.1.4609796. Protein 0.0 65
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta NC_011035.1.6448762. Protein 0.0 64
rpoB YP_003254706.1 DNA-directed RNA polymerase subunit beta CP002695.1.gene18.p0 Protein 0.0 64