Gene Information

Name : rpoB (NMV_0143)
Accession : YP_005877721.1
Strain : Neisseria meningitidis 8013
Genome accession: NC_017501
Putative virulence/resistance : Unknown
Product : DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit)
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.6
Position : 135383 - 139561 bp
Length : 4179 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme

DNA sequence : 
ATGAACTATTCGTTTACCGAGAAAAAACGTATCCGTAAGAGTTTTGCAAAGCGGGAAAATGTTTTGGAAGTTCCTTTCTT
GCTAGCAACCCAAATTGATTCTTATGCGAAGTTTTTGCAGCTGGAAAATGCTTTTGACAAACGTACCGATGACGGTCTGC
AGGCGGCATTTAATTCTATTTTCCCGATTGTGAGCCATAACGGTTATGCGCGATTGGAGTTTGTGCATTACACATTGGGC
GAGCCTTTGTTCGATATTCCCGAATGTCAGTTGCGCGGAATCACTTATGCAGCCCCCTTGCGCGCGCGTATCCGTTTGGT
GATTTTGGATAAGGAAGCATCTAAACCGACGGTAAAAGAAGTTCGTGAAAACGAAGTGTATATGGGCGAAATTCCGTTGA
TGACCCCGAGCGGTTCTTTTGTGATTAACGGCACAGAGCGTGTGATTGTTTCCCAGTTGCACCGTTCGCCCGGCGTGTTT
TTCGAGCATGACAAAGGTAAGACGCACTCTTCCGGCAAGTTGTTATTCTCCGCCCGTATCATTCCCTACCGCGGTTCATG
GTTGGATTTTGAATTTGACCCGAAAGATTTGCTGTATTTCCGTATCGACCGCCGCCGTAAAATGCCGGTAACGATTTTGT
TGAAGGCTTTGGGCTACGGCAATGAGCAAATCTTGGATATTTTCTACGACAAAGAAACGTTCTATTTGTCTTCAAACGGT
GTTCAAACCGATTTGGTCGCAGGCCGTCTGAAAGGCGAAACTGCCAAGGTCGATATCTTGGATAAAGAAGGCAATGTATT
GGTTGCCAAAGGTAAGCGCATTACTGCGAAAAATATCCGTGATATTACCAATGCAGGCCTGACCCGTTTGGATGTAGAAC
CGGAAAGCCTGCTGGGTAAAGCATTGGCTGCCGATCTGATTGATTCGGAAACCGGCGAGGTATTGGCTTCTGCCAATGAT
GAAATTACAGAAGAGTTGTTGGCCAAATTTGATATCAACGGCGTAAAAGAAATTACGACCCTTTACATCAATGAGTTGGA
TCAGGGTGCTTATATCTCCAACACCTTGCGTACGGATGAGACTGCCGGCCGGCAGGCGGCGCGTGTTGCGATTTACCGTA
TGATGCGTCCGGGCGAACCGCCCACTGAAGAGGCGGTCGAGCAATTGTTTAACCGCTTGTTCTTCAGTGAAGACAGCTAC
GATTTGTCCCGCGTAGGCCGTATGAAATTTAATACGCGCACATACGAACAAAAACTGTCCGAAGCCCAACAAAACTCTTG
GTACGGCCGCCTGCTGAACGAAACGTTTGCCGGTGCTGCCGACAAAGGCGGTTATGTCCTGAGCGTCGAAGATATTGTCG
CCTCGATTGCGACTTTGGTCGAGTTGCGTAACGGCCATGGCGAAGTGGACGATATCGATCACTTGGGCAACCGCCGAGTA
CGTTCGGTAGGCGAGCTGACTGAAAACCAATTCCGTAGCGGTTTGGCCCGTGTGGAACGTGCCGTAAAAGAACGTTTGAA
TCAGGCGGAATCAGAAAACTTGATGCCGCACGATTTGATTAATGCAAAACCTGTTTCTGCTGCTATTAAAGAATTCTTCG
GCTCCAGCCAATTGAGTCAGTTTATGGATCAGACCAATCCCTTGTCTGAAGTAACCCATAAACGCCGCGTATCCGCATTG
GGTCCGGGCGGTTTGACCCGCGAACGTGCAGGATTTGAGGTGCGGGACGTGCATCCGACCCACTACGGCCGCGTATGTCC
GATTGAAACGCCTGAAGGTCCGAACATCGGTTTGATCAACTCACTGTCCGTTTATGCGCGCACCAATGATTACGGTTTCT
TGGAAACGCCTTACCGCCGCGTTATCGACGGCAAAGTAACCGAGGAAATCGATTACTTGTCTGCCATCGAAGAAGGCCGC
TATGTGATTGCACAGGCGAATGCCGATTTGGATTCAGATGGCAATCTGATTGGCGATTTGGTTACCTGTCGTGAAAAAGG
CGAAACCATTATGGCAACGCCCGACCGCGTCCAATATATGGACGTGGCAACCGGCCAGGTGGTATCCGTTGCGGCATCCC
TGATTCCGTTCTTGGAACACGATGACGCGAACCGCGCATTGATGGGTGCGAATATGCAACGTCAGGCAGTGCCTTGCTTG
CGTCCTGAAAAACCGATGGTCGGTACCGGTATCGAGCGTTCCGTTGCCGTTGACTCTGCTACTGCAATCGTTGCCCGCCG
AGGCGGCGTGGTCGAGTATGTCGATGCCAACCGTGTTGTGATTCGTGTCCATGACGACGAAGCGACTGCCGGCGAAGTGG
GTGTCGATATTTACAACTTGGTTAAATTTACCCGTTCCAACCAATCTACCAACATCAACCAACGTCCGGCCGTAAAAGCA
GGCGACGTGTTGCAACGCGGCGACTTGGTGGCCGACGGTGCGTCTACCGACTTGGGCGAATTGGCTTTGGGTCAAAACAT
GACCATCGCCTTCATGCCATGGAACGGTTACAACTATGAAGACTCGATTCTGATTTCAGAAAAAGTGGCTGCGGATGATC
GTTACACTTCGATTCACATTGAGGAATTGAATGTCGTTGCCCGCGATACCAAGCTGGGTGCGGAAGACATTACCCGCGAT
ATTCCGAACTTGTCCGAGCGTATGCAAAACCGCTTGGACGAATCCGGTATCGTTTACATCGGTGCAGAAGTAGAAGCCGG
CGATGTGTTGGTAGGCAAAGTAACGCCTAAAGGCGAAACCCAGCTGACGCCGGAAGAAAAACTGTTGCGCGCCATCTTCG
GCGAAAAAGCGTCTGACGTAAAAGATACTTCATTGCGTATGCCTACCGGTATGAGCGGTACGGTTATCGACGTTCAAGTC
TTCACTCGTGAAGGTATTCAACGCGACAAACGCGCCCAATCCATTATCGATTCCGAGTTGAAACGCTACCGTTTGGATTT
GAACGACCAATTGCGTATTTTCGACAACGACGCATTCGACCGTATCGAACGTATGATTGTGGGTCAAAAAGCCAATGGTG
GTCCGATGAAGCTGGCTAAAGGCAGCGAAATTACTACCGAATATTTGGCGGGTCTGCCGAGCAGGCACGATTGGTTCGAT
ATCCGTCTGACCGATGAAGATTTGGCCAAGCAGTTGGAACTGATTAAAGTGAGCCTGCAACAAAAACGCGAAGAAGCGGA
CGAGTTATACGAAATCAAGAAGAAAAAACTGACCCAAGGCGACGAATTGCAACCCGGCGTACAAAAAATGGTGAAAGTTT
TTATCGCCATCAAACGCCGTCTGCAAGCCGGCGACAAAATGGCGGGCCGCCACGGTAACAAAGGCGTGGTATCGCGCATT
CTGCCAGTGGAAGACATGCCTTACATGGCGGACGGCCGTCCGGTAGACATCGTACTGAACCCATTGGGCGTACCTTCCCG
TATGAACATCGGTCAGATTTTGGAAGTTCACTTGGGTTGGGCAGCAAAAGGTATCGGCGAGCGTATCGACCGTATGCTGA
AAGAGCAACGCAAAGCAGGCGAGTTGCGCGAGTTCTTGAACAAACTCTACAACGGCAGCGGCAAGAAAGAAGATTTGGAT
GCCCTGACTGATGAAGAAATCATCGAACTGGCCTCCAACCTGCGTAAAGGTGCATCTTTCGCCTCTCCTGTATTCGACGG
TGCGAAAGAGTCTGAAATCCGCGAAATGTTGAACTTGGCTTATCCGAGCGACGATCCTGAGGTTGAAAAACTGGGCTTCA
ACGACAGTAAAACCCAAATCACGCTGTATGACGGCCGTTCAGGCGAAGCATTTGACCGCAAGGTTACAGTCGGTGTGATG
CACTATCTGAAACTGCACCACTTGGTTGACGAAAAAATGCACGCGCGTTCTACCGGTCCGTACAGTCTGGTTACCCAGCA
GCCTTTGGGCGGTAAAGCCCAGTTCGGCGGCCAACGTTTCGGCGAGATGGAGGTTTGGGCATTGGAAGCATACGGCGCGG
CATACACGCTGCAAGAGATGTTGACTGTGAAGTCTGACGACGTGAACGGTCGTACCAAAATGTACGAAAACATCGTCAAA
GGCGAACACAAAATCGATGCCGGTATGCCCGAGTCCTTCAACGTATTGGTCAAAGAGATTCGCTCACTGGGCTTGGATAT
CGATTTGGAACGCTACTGA

Protein sequence : 
MNYSFTEKKRIRKSFAKRENVLEVPFLLATQIDSYAKFLQLENAFDKRTDDGLQAAFNSIFPIVSHNGYARLEFVHYTLG
EPLFDIPECQLRGITYAAPLRARIRLVILDKEASKPTVKEVRENEVYMGEIPLMTPSGSFVINGTERVIVSQLHRSPGVF
FEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDLLYFRIDRRRKMPVTILLKALGYGNEQILDIFYDKETFYLSSNG
VQTDLVAGRLKGETAKVDILDKEGNVLVAKGKRITAKNIRDITNAGLTRLDVEPESLLGKALAADLIDSETGEVLASAND
EITEELLAKFDINGVKEITTLYINELDQGAYISNTLRTDETAGRQAARVAIYRMMRPGEPPTEEAVEQLFNRLFFSEDSY
DLSRVGRMKFNTRTYEQKLSEAQQNSWYGRLLNETFAGAADKGGYVLSVEDIVASIATLVELRNGHGEVDDIDHLGNRRV
RSVGELTENQFRSGLARVERAVKERLNQAESENLMPHDLINAKPVSAAIKEFFGSSQLSQFMDQTNPLSEVTHKRRVSAL
GPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYARTNDYGFLETPYRRVIDGKVTEEIDYLSAIEEGR
YVIAQANADLDSDGNLIGDLVTCREKGETIMATPDRVQYMDVATGQVVSVAASLIPFLEHDDANRALMGANMQRQAVPCL
RPEKPMVGTGIERSVAVDSATAIVARRGGVVEYVDANRVVIRVHDDEATAGEVGVDIYNLVKFTRSNQSTNINQRPAVKA
GDVLQRGDLVADGASTDLGELALGQNMTIAFMPWNGYNYEDSILISEKVAADDRYTSIHIEELNVVARDTKLGAEDITRD
IPNLSERMQNRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRMPTGMSGTVIDVQV
FTREGIQRDKRAQSIIDSELKRYRLDLNDQLRIFDNDAFDRIERMIVGQKANGGPMKLAKGSEITTEYLAGLPSRHDWFD
IRLTDEDLAKQLELIKVSLQQKREEADELYEIKKKKLTQGDELQPGVQKMVKVFIAIKRRLQAGDKMAGRHGNKGVVSRI
LPVEDMPYMADGRPVDIVLNPLGVPSRMNIGQILEVHLGWAAKGIGERIDRMLKEQRKAGELREFLNKLYNGSGKKEDLD
ALTDEEIIELASNLRKGASFASPVFDGAKESEIREMLNLAYPSDDPEVEKLGFNDSKTQITLYDGRSGEAFDRKVTVGVM
HYLKLHHLVDEKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYENIVK
GEHKIDAGMPESFNVLVKEIRSLGLDIDLERY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00346 YP_008207811.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR25 Protein 0.0 66
BJAB0868_00350 YP_008211676.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit Not tested AbaR26 Protein 0.0 66

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_011035.1.6448762. Protein 0.0 99
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_008702.1.4609796. Protein 0.0 75
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP002695.1.gene18.p0 Protein 0.0 74
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_009085.4918494.p0 Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_002516.2.881699.p Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_010410.6003841.p0 Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_011586.7046027.p0 Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_010400.5987325.p0 Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_010611.6233925.p0 Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_011595.7060572.p0 Protein 0.0 66
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP000034.1.gene3741. Protein 0.0 65
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) NC_002695.1.914942.p Protein 0.0 65
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP001918.1.gene250.p Protein 0.0 64
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP001138.1.gene4362. Protein 0.0 64
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP004022.1.gene2794. Protein 0.0 64
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP000647.1.gene4402. Protein 0.0 64
rpoB YP_005877721.1 DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) CP000675.2.gene392.p Protein 0.0 64