Gene Information

Name : TtJL18_1093 (TtJL18_1093)
Accession : YP_006058774.1
Strain : Thermus thermophilus JL-18
Genome accession: NC_017587
Putative virulence/resistance : Virulence
Product : 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1005197 - 1006753 bp
Length : 1557 bp
Strand : -
Note : PFAM: Aldehyde dehydrogenase family; TIGRFAM: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

DNA sequence :
ATGAGGTACGCGGACCGGGTGGCCGGGATTTCCTGGAAGACGATTGAGGAGGTGCGCCAGCGCCTCAAGGAAAGGCCTGC
CCTCCACTTCATCGCCGGGGAGTTCGTTCCCTCGGAAAGCGGGGAGACCTTTCCCTCCCTAGACCCCGCCACGAACGAGG
TCTTGGGCGTGGCGGCAAGGGGCGGGGAGAGGGAGGTGGACCGGGCGGCCAAGGCGGCCCACGAGGCCTTCCAGAGGTGG
AGCCGCACCAAGGCCAAGGAGAGGAAGCGCTACCTCTTAAGGATCGCTGAGCTCATAGAGAAGCACGCGGACGAGCTCGC
CGTGATGGAGTGCCTGGACGCGGGGCAGGTCTTAAGGATCGTCCGGGCCCAGGTGGCCCGGGCGGCGGAGAACTTCGCCT
TCTACGCTGAGTACGCCGAGCATGCCATGGAGGATAGGACCTTCCCCGTGGACCGAGACTGGCTCTACTACACCGTGCGG
GTTCCCGCAGGCCCCGTGGGGATCATCACCCCCTGGAACGCCCCCCTGATGCTCTCCACCTGGCGGATCGCCCCCGCCTT
GGCCTTTGGGAACACCGTGGTCCTGAAGCCCGCGGAGTGGAGCCCCTTCACCGCCACGAAGCTCGCGGAAATCCTAAAGG
AGGCGGACCTCCCCCCGGGGGTCTTCAACCTGGTCCAGGGCTTTGGCGAGGAGGCGGGGGCGGCCTTGGTGGCCCACCCC
CTCGTCCCCCTCCTCACCCTCACCGGGGAGACGGAGACGGGGAAAATCGTCATGCGCAATGCCGCAGACCACCTCAAGCG
CCTCTCCCCGGAGCTCGGCGGCAAAAGCCCCGCCCTGGTCTTCGCCGACGCCGACTTGGAGAGGGCCCTAGACGCCGTGG
TCTTCCAGATCTTCTCCTTCAACGGGGAAAGGTGCACGGCAAGCTCCAGGCTCCTCGTGGAGGAGAAGATCTTTGAGGAC
TTCGTGGGGAAGGTGGTGGAAAGGGCCAGGGCCATCCGGGTGGGCCACCCCCTGGACCCCGAGACCGAGGTGGGGCCCTT
GATCCACCCCGAGCACCTCCAGAGGGTCCTGGGCTACGTGGAGGCGGGGAAGCGGGAAGGGGCGAGGCTCCTCGTGGGCG
GGGAGCGGGCCAAGACCTCCTTCCGGGGGGAGGACCTCTCCCGGGGGAACTACCTCCTTCCCACGGTTTTCGTGGGGGAG
AACCACATGAAAATCGCCCAGGAGGAGATCTTCGGGCCCGTCCTCGTGGCCATCCCCTTCAGGGACGAGGAGGAGGCCTT
GAAAAAGGCGAACGACACCAAGTACGGCCTCGCCGCCTACGTCTTCACCCGGGACCTGGAGAGGGCCCACAGGCTCGCCT
TGGAGCTCGAGGCGGGGATGGTCTACCTGAATAGCCACAACGTCCGCCACCTGCCCACGCCCTTCGGCGGGGTGAAGGGA
AGCGGGGACCGGAGGGAGGGCGGCACCTACGCCCTGGACTTCTACACCGACCTCAAGACCATCGCCCTTCCCCTCCGCCC
CCCGCACGTGCCCAAGTTCGGGAAGGAAGGGAGGTAG

Protein sequence :
MRYADRVAGISWKTIEEVRQRLKERPALHFIAGEFVPSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQRW
SRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLYYTVR
VPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHP
LVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFED
FVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVGE
NHMKIAQEEIFGPVLVAIPFRDEEEALKKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKG
SGDRREGGTYALDFYTDLKTIALPLRPPHVPKFGKEGR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hpaE AAO17179.1 HpaE Not tested tcd island Protein 2e-88 46
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 3e-65 44
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 7e-62 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 1e-63 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 1e-63 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 1e-63 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-63 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TtJL18_1093 YP_006058774.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase VFG0082 Protein 3e-62 41