Gene Information

Name : CKO_02615 (CKO_02615)
Accession : YP_001454160.1
Strain : Citrobacter koseri ATCC BAA-895
Genome accession: NC_009792
Putative virulence/resistance : Virulence
Product : DNA-binding transcriptional activator CusR
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 2421729 - 2422427 bp
Length : 699 bp
Strand : +
Note : response regulator in two-component regulatory system with CusS; regulates the copper efflux system

DNA sequence : 
GTGAAGGAAGACGTGATGAAGATTCTGATAGTCGAAGACGAGAAAAAAACCGGTGAATACCTGACCAAAGGTCTGACGGA
AGCGGGCTTCGTGGTGGACCTGGCGGATAACGGGCTTAACGGGTATCACCTGGCGATGACGGGAGATTACGATCTGCTGA
TCCTCGACATCATGCTGCCGGATGTGAATGGCTGGGATATTGTCCGTATGCTGCGCACCGCCAACAAAGGCATGCCAATC
CTTCTTCTTACCGCGCTGGGCACCATTGAACACAGGGTAAAAGGTCTGGAGCTGGGGGCTGACGACTATCTGGTTAAACC
GTTCGCTTTCGCTGAATTACTGGCCCGCGTCAGAACGCTGCTGCGTCGCGGCGCGGCGGTGATGGTCGAAAGTCAGTTTC
AGGTCGCGGATTTGACGCTCGATCTGGTTAGCAGAAAAGTGACCCGCAACGGCATGCGCATCACGCTCACCAGTAAAGAG
TTTACGCTACTGGAGTTTTTCGTCCGCCACCAGGGAGAAGTCTTGCCCCGCTCGCTGATCGCTTCCCAGGTCTGGGATAT
GAACTTTGACAGCGATACCAACGCGATTGACGTTGCCGTTAAACGGCTGCGCGCGAAAATCGATAACGAGTTCGAACCGA
AACTCATCCAGACCGTGCGCGGCGTGGGCTATGTGCTTGAGGTACCGGATGGTGACTAA

Protein sequence : 
MKEDVMKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLLILDIMLPDVNGWDIVRMLRTANKGMPI
LLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVMVESQFQVADLTLDLVSRKVTRNGMRITLTSKE
FTLLEFFVRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNEFEPKLIQTVRGVGYVLEVPDGD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 6e-57 54
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 6e-57 53

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0111 Protein 1e-99 94
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0347 Protein 2e-86 81
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0083 Protein 6e-70 61
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0197 Protein 1e-64 60
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0638 Protein 6e-63 60
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0308 Protein 1e-63 59
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR BAC0125 Protein 1e-63 55
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR AE000516.2.gene3505. Protein 2e-27 43
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_003923.1003417.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_013450.8614146.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_002951.3238224.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_007793.3914065.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_002758.1121390.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_010079.5776364.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_002952.2859858.p0 Protein 6e-35 42
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR NC_007622.3794948.p0 Protein 6e-35 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR VFG0596 Protein 2e-57 54
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR VFG1390 Protein 3e-45 45
CKO_02615 YP_001454160.1 DNA-binding transcriptional activator CusR VFG1389 Protein 1e-34 41