Gene Information

Name : hilA (CV_2640)
Accession : NP_902310.1
Strain : Chromobacterium violaceum ATCC 12472
Genome accession: NC_005085
Putative virulence/resistance : Virulence
Product : invasion protein regulator
Function : -
COG functional category : K : Transcription
COG ID : COG3710
EC number : -
Position : 2850034 - 2851719 bp
Length : 1686 bp
Strand : +
Note : Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system

DNA sequence :
ATGGCGTTACATAACGATGGTTTCATCAATCGGCAATTCGTCTTCGGCGATTTTGTCCTGCAATTCGACGGCGTGCTCTG
TCACCAGGAACAGCAGATCAGCGTTCCGCCCAAAGAATTGGCCGTACTCACCGCCTTGCTGGAGGCAGCCGGCGAACTGG
TGAGCAAGGACGCGTTGCTGGACAAGGTCTGGCCGGACGGCGACGTCAACGAGGAATCGCTGACGCGCTGCATCTACGCA
TTGCGCCGCATCCTGCTGGAAGACAAGAGCAACCGCTACATCGATACCGTCTACGGCAAGGGATACCGCTTCAGCCGGCC
GGTGGCGGTGGTGTCCCGCCCGACGGCATCCGCGCAGAAGTGCACGATGGCCATCCTGCCCTTCCGCACCGACGGCCAGC
TGGACTCTCTGGAGCTGCATGCCGCGCTGGTCCAGTGCCTGTCGCGCTACTCGCCGTTCGGCCTGGTGGTGATGCCTGCC
ACCATCACCCGCAATTGCGGCGACATCGCCGACATCATCGCCATGATCGACCAGTTGCGGCCCGACTATTACCTGGCCGG
CCAGGTGCAGCAACAGGGGGATTCCTGGCTGCTGCGGGTGGAGCTGGTGCGCGCCGACGGCCATCAGTTGGTTCACCACG
AAAGCATAGAGATCGGCCCGGGCGAGCATATCGCCGCGCTGCAGACCCGGCTGGCGAGCCTGCTGCCGCAACGCATTCCC
GGCTTGCGCTGGCATCATGGCAACGGCAGCCAGCTGGACTCCCTGGACATGGCCATCACGTATCTGAACGGCCGCCATGA
ACTGCAGCAGCACACCCCTTCCAGCCTGAAACGCGCGCTGGCGCTGTTCCTGCAATGCACCAGCAGCCAACCCGGCAACG
CGCTGCCCTACTGCAGCCTGGCCGAATGCTATCTGGCGCTGGCCCAGCTGGGCCTGTTCGACCAGGAGCGCGCGCTGGAC
GGCGCCCAGCAGGCGGTCGACCGCGCGGTGGCGCTGGACGCGGCCAATCCGCAGGCGCTGGGCCTGCTGGCCCTGCTGAG
CAGCCTGCGCGGACAACAGACCATCGCCGAAGCCTTGTTCGAACAGGCGCGCATGCTGGCGCCCGATTCGATCGACATCC
ACTACTACCACGCCTGGCACCTGTTTCTGTCCGACCGCATTCCCCTGGCGCAACGCTCGCTCGATGCTTGCCTGGAACGC
GATCCCTCCCGCATCGCGGCCAGCATGCTGCAGCTGTGGCTGACCTATTGCGAGCACCGGCTGGACGAGGCGGTGGCGTT
GGGCAAACGCCAGCTGTGCCAGTACGGCCAGGATCATCCGGTATTGCAGAGCATGCTGGGGCTGATGCTGGCCATCCAGG
GGCAACACGCCCAGGCGGAAGAATTGGCCGCGGCGGTCAAGGCGTCGGGCGAAGAAGCCGGCCTGCTCGCCGTCAACGGC
TGCTACATCGCTCATTGCCGGATGGGAGACGCCGCGCGCCCGTTGCTGCAGGATTTTTTGTCCCGCGTCGACTGCCGCCA
GGTCCGCTCCGGCCTGCTGCCGCTGATCCTGGCGCTGCATGGCCGCGCCGGGGCGCTGCATCTGTTGGGCCAGCTGGAAT
CCGACCGCTACCTGTGGCTGCGGGCATCCCGCCAGGATCCGCGCCTGGCCGGCCTGTTCCATCCCCACTTGTCCGAAGCC
GCCTGA

Protein sequence :
MALHNDGFINRQFVFGDFVLQFDGVLCHQEQQISVPPKELAVLTALLEAAGELVSKDALLDKVWPDGDVNEESLTRCIYA
LRRILLEDKSNRYIDTVYGKGYRFSRPVAVVSRPTASAQKCTMAILPFRTDGQLDSLELHAALVQCLSRYSPFGLVVMPA
TITRNCGDIADIIAMIDQLRPDYYLAGQVQQQGDSWLLRVELVRADGHQLVHHESIEIGPGEHIAALQTRLASLLPQRIP
GLRWHHGNGSQLDSLDMAITYLNGRHELQQHTPSSLKRALALFLQCTSSQPGNALPYCSLAECYLALAQLGLFDQERALD
GAQQAVDRAVALDAANPQALGLLALLSSLRGQQTIAEALFEQARMLAPDSIDIHYYHAWHLFLSDRIPLAQRSLDACLER
DPSRIAASMLQLWLTYCEHRLDEAVALGKRQLCQYGQDHPVLQSMLGLMLAIQGQHAQAEELAAAVKASGEEAGLLAVNG
CYIAHCRMGDAARPLLQDFLSRVDCRQVRSGLLPLILALHGRAGALHLLGQLESDRYLWLRASRQDPRLAGLFHPHLSEA
A

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hilA YP_217795.1 invasion protein regulator Virulence SPI-1 Protein 1e-106 46
hilA NP_461797.1 invasion protein regulator Virulence SPI-1 Protein 1e-106 46
iagA NP_457270.1 invasion protein regulator Not tested SPI-1 Protein 1e-106 46
iagA NP_806479.1 invasion protein regulator Virulence SPI-1 Protein 1e-106 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hilA NP_902310.1 invasion protein regulator VFG0538 Protein 5e-107 46