Gene Information

Name : covR (MGAS10750_Spy0277)
Accession : YP_601771.1
Strain : Streptococcus pyogenes MGAS10750
Genome accession: NC_008024
Putative virulence/resistance : Virulence
Product : Response regulator CsrR
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 291638 - 292324 bp
Length : 687 bp
Strand : +
Note : -

DNA sequence : 
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGACATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Protein sequence : 
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 8e-37 43
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 3e-36 43
c3565 NP_755440.1 response regulator Not tested PAI I CFT073 Protein 4e-33 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
covR YP_601771.1 Response regulator CsrR HE999704.1.gene1528. Protein 6e-59 62
covR YP_601771.1 Response regulator CsrR AE015929.1.gene1106. Protein 3e-49 54
covR YP_601771.1 Response regulator CsrR NC_010079.5776364.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_002952.2859858.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_007622.3794948.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_003923.1003417.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_013450.8614146.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_002951.3238224.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_007793.3914065.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_002758.1121390.p0 Protein 3e-51 53
covR YP_601771.1 Response regulator CsrR NC_012469.1.7685629. Protein 2e-38 43
covR YP_601771.1 Response regulator CsrR HE999704.1.gene2815. Protein 3e-39 42
covR YP_601771.1 Response regulator CsrR BAC0125 Protein 7e-36 41
covR YP_601771.1 Response regulator CsrR AE016830.1.gene1681. Protein 3e-39 41
covR YP_601771.1 Response regulator CsrR BAC0197 Protein 2e-32 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
covR YP_601771.1 Response regulator CsrR VFG1390 Protein 3e-41 43
covR YP_601771.1 Response regulator CsrR VFG0596 Protein 3e-37 43
covR YP_601771.1 Response regulator CsrR VFG1702 Protein 2e-33 41