PAI Gene Information


Name : cagA
Accession : BAD51756.1
PAI name : cag PAI
PAI accession : AB190946
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : cytotoxin associated protein A
Function : -
Note : -
Homologs in the searched genomes :   49 hits    ( 47 protein-level,   2 DNA-level )  
Publication :
    -Yamazaki,S., Yamakawa,A. and Azuma,T., "Direct Submission", Submitted (22-SEP-2004) Takeshi Azuma, University of Fukui, Faculty of Medical Sciences, Second depertment of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).

    -Yamazaki,S., Yamakawa,A., Okuda,T., Ohtani,M., Suto,H., Ito,Y., Yamazaki,Y., Keida,Y., Higashi,H., Hatakeyama,M. and Azuma,T., "Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan", J. Clin. Microbiol. 43 (8), 3906-3916 (2005) PUBMED 16081930.


DNA sequence :
ATGACTAACGAAACTATTGATCAAACACCAAGCCAAACAGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGTAGC
TTTTCTTGAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATAACA
GGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAGGAATTCGCTAATAAAGCGATCAAAAATCCTGCCAAAAAGAATCAG
TATTTTTCAAACTTTATCAGTAAGAGCAATGATTTAATCAACAAAGACAGTCTCATTGATATAGGTTCTTCCACAAAGAG
CTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGGATTGGGTGTCCCATCAAAAAGATCCATCTAAAATCAACA
CCCAAAGAATCCGAAGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAAAAAGCGGAGTTTTTGAGG
TCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAGATCCAATCAGATCAAAAATTCATGGGCGTGTTTGATGA
ATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGTCTACTGGAGAGCCTACTGGTGGGGATTGGCTTGATATTT
TTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCGATCAAGAACCAGTTTCTCATGTCCAA
CCAGATATAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAATCTAGGGATTTGCTTGATGAAAGGGGTAATTT
TTCTAAATTCACTCTTGGTGATATGGAAATGTTAGATGTTGAGGGTGTCGCTGATATTGATCCTAATTACAAGTTCAACC
AATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTA
TTGTATGGGGGCAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCGACAA
TGTGGCTACACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACAACC
CTAGTTTTTATCTCTACAAAGAAGACCAGCTCACAGGCTTGAAACAAGCATTGAGCCAAGAAGAGATCCAAAACAAAGTA
GATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGATAACTTGAGCAAGAAAGAGAAAGAAAAATTCCAAAATGA
GATTGAAGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAG
ACAAAAAACATTTAGCTTTAGTTGCTGAGTTTGGTAATGGGGAATTGAGCTACACTCTCAAAGATTATGGGAAAAAACAA
GATAAAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAACATGATGGCGTGATGTTTGTTAATTATTC
TAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTGGAAGCAA
ATCTTAGTAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCAATAGTTATATAAGGCGAGACTTAGAA
GATAAACTGATGGCTAAAGGATTGTCCCAACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAAGAATT
GGTTGAAATAGCTTTAAACTTCAATAAAACTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAAGCTC
AGAAAGATCTTGAAAAATCTATAAGAAAACGAGAGCATTTAGAGAAAGAAGTAACGAAAAAATTGGAGAACAGAAATGGC
AACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCAATTATCAACGAAGAGGCTGG
TAAGGAAGCAAGAGCGGTCGCTTGCGTTCAGAATCTTAAAGGCATCAGAATGGAATTGTCTGATAAGCTTGAAAACATCA
ACAAGAATTTGAAAGACTTTGATAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGACAGAAGAA
ACGCTAAAAGCCCTTAAAAGCTTGGTGAAAGATTCAGGCATCAGTCTAGAATGGATTTCAAAAGTTGAAAACCTTAATAC
AGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAATACAAGCAAAAAGCGACCTTGAAAATTCCA
TTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAGCTGTATCAATAGCTAGGGCAATA
GGCGATTTCAGTGGGGTAGAGCAAGCGCTAGCCGATCTCAAGAATTTCTCAAAAGGACAATTGACTCAACAAGCTCAAAA
AAATGAAGATTTCAATACTGGAAAAAATTCTGAACTATACCAATCCGTTAAGAATGGTGTAAATGGAACCCTAGTCGGTA
ATGGGTTATCTAAAGCAGAAGCCACAACTCTTTCTAAAAACTTTTCGGACATCAGGAAAGAGTTGAATGCAAAACTTGGA
AATTTCAATAACAATAATAATGATGGACTCAAAAATAGCATAGAACCCATTTATGCTAAAGTTAATAAAAAGAAAGCAGG
ACAAGCAGCTAGCCCTGAAGAGTCCATTTATACTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCAACTCAATCAAG
CAGCAAGTGGTTTCGGTAATGTAGGGCAAGCGGGATTCCCTTTGAAAAGGCATACTAAAGTTGATGATCTCAGTAAGGTA
GGGCTTTCAGCTAATCATGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGACAAGGCATACTAA
AGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAAGAATTGACTCAGAAAATTGACAATCTCAACCAGGTGCTAT
CAGAAGCTAAAGCATGTCATCTTGACAACCTAGAGCAAATGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATG
AATCTATATGTTGAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAACTAGACAATTACGCTACTAACAGCCACAC
ACGCATTAATAGCAATGTCCGAAATGGAACAATCAATGAAAAAGCGACTGGTATGCTAACGCAAAAAAACCCTGAGTGGC
TCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGTGCTCCTTTGTCAGCGTATGATAAAATTGGATTCAAC
CAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAGGTTGAGCAATGCCGTAAAAGACATTAAGTCTGG
CTTTGTGCAATTTTTAACCAATGCATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAA
ATACTACCAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence :
MTNETIDQTPSQTAFNPQQFINNLQVAFLEVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEFANKAIKNPAKKNQ
YFSNFISKSNDLINKDSLIDIGSSTKSFQKFGTQRYQIFMDWVSHQKDPSKINTQRIRSFMENIIQPPISDDKEKAEFLR
SAKQSFAGIIIGNQIQSDQKFMGVFDESLKERQEAEKNGGSTGEPTGGDWLDIFLSFVFNKKQSSDLKETLDQEPVSHVQ
PDIATTTTDIQGLPPESRDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSL
LYGGNGGPEARHDWNATVGYKNQQGDNVATLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQEEIQNKV
DFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLKDYGKKQ
DKALDRETKTTLQGNLKHDGVMFVNYSNFKYTNASKSPDKGVGATNGVSHLEANLSKVAVFNLPNLNNLAINSYIRRDLE
DKLMAKGLSQQEANKLIKDFLNSNKELVEIALNFNKTVAEAKNTGNYDEVKKAQKDLEKSIRKREHLEKEVTKKLENRNG
NKNRMEAKAQANSQKDKIFAIINEEAGKEARAVACVQNLKGIRMELSDKLENINKNLKDFDKSFDEFKNGKNKDFSKTEE
TLKALKSLVKDSGISLEWISKVENLNTALNEFKNGKNKDFSKVIQAKSDLENSIKDVIINQKITDKVDNLNQAVSIARAI
GDFSGVEQALADLKNFSKGQLTQQAQKNEDFNTGKNSELYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIRKELNAKLG
NFNNNNNDGLKNSIEPIYAKVNKKKAGQAASPEESIYTQVAKKVNAKIDQLNQAASGFGNVGQAGFPLKRHTKVDDLSKV
GLSANHEPIYATIDDLGGPFPLTRHTKVDDLSKVGLSREQELTQKIDNLNQVLSEAKACHLDNLEQMIDKLKDSTKKNVM
NLYVESAKKVPTSLSAKLDNYATNSHTRINSNVRNGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAPLSAYDKIGFN
QKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNAFSTGSYSLMKANVEHGVKNTTKGGFQKS