PAI Gene Information


Name : S4049 (S4049)
Accession : NP_839217.2
PAI name : SHI-2
PAI accession : NC_004741_P2
Strain : Shigella flexneri 2002017
Virulence or Resistance: Not determined
Product : insertion sequence 2 OrfA protein
Function : -
Note : IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
Homologs in the searched genomes :   568 hits    ( 558 protein-level,   10 DNA-level )  
Publication :
    -Wei,J., Goldberg,M.B., Burland,V., Venkatesan,M.M., Deng,W., Fournier,G., Mayhew,G.F., Plunkett,G. III, Rose,D.J., Darling,A., Mau,B., Perna,N.T., Payne,S.M., Runyen-Janecky,L.J., Zhou,S., Schwartz,D.C. and Blattner,F.R., "Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T", Infect. Immun. 71 (5), 2775-2786 (2003) PUBMED 12704152 REMARK Erratum:[Infect Immun. 2003 Jul;71(7):4223].

    -Wei,J., Goldberg,M.B., Burland,V., Venkatesan,M.M., Deng,W., Fournier,G., Mayhew,G.F., Plunkett,G. III, Rose,D.J., Darling,A., Mau,B., Perna,N.T., Payne,S.M., Runyen-Janecky,L.J., Zhou,S., Schwartz,D.C. and Blattner,F.R., "Direct Submission", Submitted (23-APR-2003) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Wei,J., Goldberg,M.B., Burland,V., Venkatesan,M.M., Deng,W., Fournier,G., Mayhew,G.F., Plunkett,G. III, Rose,D.J., Darling,A., Mau,B., Perna,N.T., Payne,S.M., Runyen-Janecky,L.J., Zhou,S., Schwartz,D.C. and Blattner,F.R., "Direct Submission", Submitted (13-JUN-2002) Genetics Laboratory, University of Wisconsin - Madison, 445 Henry Mall, Madison, WI 53706, USA.


DNA sequence :
ATGATTGATGTCTTAGGGCCGGAGAAACGCAGACGGCGTACCACACAGGAAAAGATCGCAATTGTTCAGCAGAGCTTTGA
ACCGGGGATGACGGTCTCCCTCGTTGCCCGGCAACATGGTGTAGCAGCCAGCCAGTTATTTCTCTGGCGTAAGCAATACC
AGGAAGGAAGTCTTACTGCTGTGGCCGCCGGAGAACAGGTTGTTCCTGCCTCTGAACTTGCTGCCGCCATGAAGCAGATT
AAAGAACTCCAGCGCCTGCTCGGCAAGAAAACGATGAAAAATGAACTCCTCAAAGAAGCCGTTGAATATGGACGGGCAAA
AAAGTGGATAGCGCACGCGCCCTTATTGCCCGGGGATGGGGAGTAA

Protein sequence :
MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI
KELQRLLGKKTMKNELLKEAVEYGRAKKWIAHAPLLPGDGE