PAI Gene Information


Name : SAR1899 (SAR1899)
Accession : YP_041281.1
PAI name : vSa_beta
PAI accession : NC_002952_P3
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Not determined
Product : type I restriction modification system modification protein
Function : -
Note : Similar to Escherichia coli type I restriction enzyme EcoR124II M protein HsdM SW:T1M1_ECOLI (P10484) (520 aa) fasta scores: E(): 6.4e-73, 42.18% id in 512 aa, and to Streptococcus thermophilus type IC modification subunit HsdM TR:Q9RNW1 (EMBL:AF177167) (
Homologs in the searched genomes :   423 hits    ( 422 protein-level,   1 DNA-level )  
Publication :
    -Holden,M.T.G., "Direct Submission", Submitted (23-JUN-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: mh3@sanger.ac.uk.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance", Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9786-9791 (2004) PUBMED 15213324.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Direct Submission", Submitted (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Kenny,J.G., Ward,D., Josefsson,E., Jonsson,I.M., Hinds,J., Rees,H.H., Lindsay,J.A., Tarkowski,A. and Horsburgh,M.J., "The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications", PLoS ONE 4 (2), E4344 (2009) PUBMED 19183815 REMARK Publication Status: Online-Only.


DNA sequence :
ATGTCTATTACTGAAAAACAACGTCAGCAACAAGCTGAATTACATAAAAAATTATGGTCGATTGCGAATGATTTAAGAGG
GAACATGGATGCGAGTGAATTCCGTAATTACATTTTAGGCTTGATTTTCTATTGCTTCTTATCTGAAAAAGCCGAACAAG
AATATGCAGATGCCTTGTCAGGTGAAGACATCACGTATCAAGAAGCATGGGCAGATGAAGAATACCGTGAAGACTTAAAA
GTAGAATTAATTGACCAAGTCGGTTACTTCATTGAGCCACAAGATTTATTCAGCGCGATGATTCATGAAATTGAAACGCA
AGATTTCGATATCGAACATCTGGCGACGGCAATTCGTAAAGTTGAAACATCAACACTAGGTGAAGAAAGTGAAAATGACT
TTATCGGACTGTTCAGCGATATGGACTTAAGTTCAACGCGTTTAGGTAACAATGTCAAAGAACGTACTGCGTTAATTTCC
AAAGTTATGGTTAATCTTGACGATTTACCATTCGTTCACAGTGATATGGAAATTGATATGTTAGGTGATGCATATGAATT
CCTTATCGGGCGCTTTGCGGCGACAGCGGGTAAAAAAGCTGGCGAGTTCTATACACCACAACAAGTATCTAAGATACTGG
CAAAGATTGTCACAGACGGTAAAGATAAATTACGTCACGTGTATGACCCAACATGTGGTTCAGGTTCATTACTGTTGCGT
GTTGGTAAAGAGACACAAGTATATCGTTATTTCGGACAAGAACGTAACAATACCACATACAACTTAGCACGCATGAACAT
GTTGTTACATGATGTACGTTATGAGAACTTTGATATCCGTAATGATGATACGTTGGAAAATCCAGCCTTTTTAGGCAATA
CATTTGATGCGGTTATTGCGAACCCACCATACAGTGCGAAATGGACAGCAGATTCAAAATTTGAAAATGATGAACGTTTT
AGTGGTTACGGCAAACTTGCGCCAAAATCCAAAGCAGACTTTGCCTTTATTCAACACATGGTACATTACTTAGACGATGA
AGGTACCATGGCCGTTGTACTCCCACATGGTGTCTTATTCCGTGGTGCCGCAGAAGGTATCATTCGTCGTTATTTAATTG
AAGAAAAGAACTACTTAGAAGCCGTGATTGGTTTGCCAGCGAATATTTTCTATGGGACAAGTATTCCAACATGTATTTTA
GTATTTAAAAAATGTCGCCAACAAGACGACAACGTATTATTTATCGATGCATCCAATGATTTTGAAAAAGGAAAAAATCA
AAACCATTTAAGCGATGCCCAAGTCGAACGTATTATAGACACATATAAGCGTAAAAAAACGATTGATAAATATAGCTACA
GCGCGACATTACAAGAGATTGCCGATAACGATTACAACTTAAACATACCGCGATATGTCGATACATTCGAAGAAGAAGCG
CCAATTGATTTAGATCAAGTCCAACAAGATTTGAAAAATATCGATAAAGAAATCGCAGAAATTGAACAAGAAATCAATGC
ATACCTGAAAGAACTTGGGGTGTTGAAAGATGAGTAA

Protein sequence :
MSITEKQRQQQAELHKKLWSIANDLRGNMDASEFRNYILGLIFYCFLSEKAEQEYADALSGEDITYQEAWADEEYREDLK
VELIDQVGYFIEPQDLFSAMIHEIETQDFDIEHLATAIRKVETSTLGEESENDFIGLFSDMDLSSTRLGNNVKERTALIS
KVMVNLDDLPFVHSDMEIDMLGDAYEFLIGRFAATAGKKAGEFYTPQQVSKILAKIVTDGKDKLRHVYDPTCGSGSLLLR
VGKETQVYRYFGQERNNTTYNLARMNMLLHDVRYENFDIRNDDTLENPAFLGNTFDAVIANPPYSAKWTADSKFENDERF
SGYGKLAPKSKADFAFIQHMVHYLDDEGTMAVVLPHGVLFRGAAEGIIRRYLIEEKNYLEAVIGLPANIFYGTSIPTCIL
VFKKCRQQDDNVLFIDASNDFEKGKNQNHLSDAQVERIIDTYKRKKTIDKYSYSATLQEIADNDYNLNIPRYVDTFEEEA
PIDLDQVQQDLKNIDKEIAEIEQEINAYLKELGVLKDE