PAI Gene Information


Name : chs (SAUSA300_1920)
Accession : YP_494571.1
PAI name : phi_Sa3
PAI accession : NC_007793_P6
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Not determined
Product : chemotaxis-inhibiting protein CHIPS
Function : -
Note : secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial
Homologs in the searched genomes :   20 hits    ( 20 protein-level )  
Publication :
    -Diep,B.A., Gill,S.R., Chang,R.F., Phan,T.H., Chen,J.H., Davidson,M.G., Lin,F., Lin,J., Carleton,H.A., Mongodin,E.F., Sensabaugh,G.F. and Perdreau-Remington,F., "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus", Lancet 367 (9512), 731-739 (2006) PUBMED 16517273.

    -Diep,B.A., Gill,S.R., Chang,R.F., Phan,T.H., Chen,J.H., Davidson,M.G., Lin,F., Lin,J., Carleton,H.A., Mongodin,E.F., Sensabaugh,G.F. and Perdreau-Remington,F., "Direct Submission", Submitted (11-FEB-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Diep,B.A., Gill,S.R., Chang,R.F., Phan,T.H., Chen,J.H., Davidson,M.G., Lin,F., Lin,J., Carleton,H.A., Mongodin,E.F., Sensabaugh,G.F. and Perdreau-Remington,F., "Direct Submission", Submitted (30-JAN-2006) Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.


DNA sequence :
ATGAAAAAGAAATTAGCAACAACAGTTTTAGCATTAAGTTTTTTAACGGCAGGAATCAGTACACACCATCATTCAGCGAA
AGCTTTTACTTTTGAACCGTTTCCTACAAATGAAGAAATAGAATCAAATAAGAAAATGTTAGAGAAAGAAAAAGCTTATA
AAGAATCATTTAAAAATAGTGGTCTTCCTACAACGCTAGGAAAATTAGATGAACGTTTGAGAAATTATTTAAAGAAAGGC
ACAAAAAATTCTGCTCAATTTGAAAAAATGGTTATTTTAACTGAAAATAAAGGTTACTATACAGTATATCTGAATACACC
ACTTGCTGAAGATAGAAAAAATGTTGAGTTACTAGGTAAAATGTATAAAACATACTTCTTTAAAAAAGGAGAGTCTAAAT
CATCTTATGTAATTAATGGTCCTGGAAAAACTAATGAATATGCATACTAA

Protein sequence :
MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKMLEKEKAYKESFKNSGLPTTLGKLDERLRNYLKKG
TKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY