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Homologs of nadC gene of NC_007297_P1

802

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) nadC
( YP_006932266.1 )

nicotinate-nucleotide diphosphorylase

NC_018936
(Streptococcus pyogenes A20)

6e-124

100

2) SPYALAB49_000206
( YP_006071372.1 )

nicotinate-nucleotide diphosphorylase

NC_017596
(Streptococcus pyogenes Alab49)

6e-124

100

3) SPYALAB49_001084
( YP_006072236.1 )

nicotinate-nucleotide diphosphorylase

NC_017596
(Streptococcus pyogenes Alab49)

6e-124

100

4) nadC
( YP_007586746.2 )

nicotinate-nucleotide pyrophosphorylase

NC_020540
(Streptococcus pyogenes M1 476)

6e-124

100

5) nadC
( YP_001128333.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009332
(Streptococcus pyogenes Manfredo)

6e-124

100

6) M6_Spy1061
( YP_060379.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006086
(Streptococcus pyogenes MGAS10394)

6e-124

100

7) nadC
( YP_602680.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008024
(Streptococcus pyogenes MGAS10750)

6e-124

100

8) nadC
( YP_281534.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007297
(Streptococcus pyogenes MGAS5005)

6e-124

100

9) spyM18_1346
( NP_607448.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003485
(Streptococcus pyogenes MGAS8232)

6e-124

100

10) nadC
( YP_599777.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008023
(Streptococcus pyogenes MGAS2096)

8e-124

11) nadC
( YP_279637.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007296
(Streptococcus pyogenes MGAS6180)

8e-124

12) nadC
( YP_595904.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008021
(Streptococcus pyogenes MGAS9429)

8e-124

13) nadC
( NP_268573.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002737
(Streptococcus pyogenes SF370)

8e-124

14) L897_05425
( YP_008243356.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021807
(Streptococcus pyogenes HSC5)

1e-123

15) nadC
( YP_597782.1 )

Nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_008022
(Streptococcus pyogenes MGAS10270)

1e-123

16) nadC
( NP_664817.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004070
(Streptococcus pyogenes MGAS315)

2e-123

17) Spy49_0176
( YP_002285217.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011375
(Streptococcus pyogenes NZ131)

2e-123

18) SPs0845
( NP_802107.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004606
(Streptococcus pyogenes SSI-1)

2e-123

19) nadC
( YP_005388264.1 )

nicotinate-nucleotide pyrophosphorylase protein NadC

NC_017040
(Streptococcus pyogenes MGAS15252)

6e-123

20) nadC
( YP_005410971.1 )

nicotinate-nucleotide pyrophosphorylase protein NadC

NC_017053
(Streptococcus pyogenes MGAS1882)

6e-123

21) nadC
( YP_002741283.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012468
(Streptococcus pneumoniae 70585)

2e-121

22) nadC
( YP_006700710.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018594
(Streptococcus pneumoniae A45)

2e-121

23) SPAP_2044
( YP_003877595.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014494
(Streptococcus pneumoniae AP200)

2e-121

24) nadC
( YP_817233.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008533
(Streptococcus pneumoniae D39)

2e-121

25) nadC
( YP_002038597.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011072
(Streptococcus pneumoniae G54)

2e-121

26) nadC
( YP_001695369.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010380
(Streptococcus pneumoniae Hungary19A-6)

2e-121

27) nadC
( YP_002737018.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012466
(Streptococcus pneumoniae JJA)

2e-121

28) nadC
( NP_359421.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003098
(Streptococcus pneumoniae R6)

2e-121

29) MYY_1937
( YP_006254127.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017769
(Streptococcus pneumoniae ST556)

2e-121

30) nadC
( YP_002743346.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012469
(Streptococcus pneumoniae Taiwan19F-14)

2e-121

31) nadC
( YP_003723454.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014251
(Streptococcus pneumoniae TCH8431/19A)

2e-121

32) nadC
( YP_001836700.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010582
(Streptococcus pneumoniae CGSP14)

5e-121

33) HMPREF1038_02012
( YP_006744113.1 )

nicotinate-nucleotide diphosphorylase

NC_018630
(Streptococcus pneumoniae gamPNI0373)

5e-121

34) nadC
( YP_003880247.1 )

nicotinate-nucleotide diphosphorylase

NC_014498
(Streptococcus pneumoniae 670-6B)

1e-120

35) nadC
( YP_007765158.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_021006
(Streptococcus pneumoniae SNP034156)

1e-120

36) nadC
( YP_002511890.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011900
(Streptococcus pneumoniae ATCC 700669)

6e-121

37) nadC
( YP_006063342.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_017591
(Streptococcus pneumoniae INV104)

6e-121

38) nadC
( YP_006067083.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_017593
(Streptococcus pneumoniae INV200)

6e-121

39) nadC
( YP_002739102.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012467
(Streptococcus pneumoniae P1031)

6e-121

40) SP_2016
( NP_346443.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003028
(Streptococcus pneumoniae TIGR4)

6e-121

41) nadC
( YP_006065164.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_017592
(Streptococcus pneumoniae OXC141)

1e-120

42) nadC
( YP_007815321.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_021028
(Streptococcus pneumoniae SNP034183)

1e-120

43) nadC
( YP_007813501.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_021026
(Streptococcus pneumoniae SNP994038)

1e-120

44) nadC
( YP_007764175.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_021005
(Streptococcus pneumoniae SNP994039)

1e-120

45) HMPREF0409_01960
( YP_008020456.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_021281
(Fusobacterium sp. 4_8)

3e-72

46) nadC
( YP_004831770.1 )

nicotinate-nucleotide diphosphorylase

NC_015975
(Lactobacillus ruminis ATCC 27782)

1e-67

47) RTO_13590
( YP_007786491.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021015
([Ruminococcus] torques L2-14)

3e-67

48) CL2_05770
( YP_007788634.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021016
(butyrate-producing bacterium SSC/2)

4e-67

49) FN0010
( NP_602924.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003454
(Fusobacterium nucleatum ATCC 25586)

2e-65

50) CC1_05300
( YP_007768845.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021009
(Coprococcus catus GD/7)

1e-63

51) ELI_3093
( YP_003961025.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014624
(Eubacterium limosum KIST612)

1e-62

52) CCU_24270
( YP_007797123.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021018
(Coprococcus sp. ART55/1)

2e-62

53) HMPREF0389_00714
( YP_005054854.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_016630
(Filifactor alocis ATCC 35896)

3e-62

54) Clocel_2166
( YP_003843673.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014393
(Clostridium cellulovorans 743B)

3e-62

55) MHY_05050
( YP_007834251.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021041
(Megamonas hypermegale ART12/1)

5e-62

56) ROI_23650
( YP_007832384.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021040
(Roseburia intestinalis M50/1)

1e-61

57) RO1_13890
( YP_007777790.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021012
(Roseburia intestinalis XB6B4)

1e-61

58) nadC
( YP_004320485.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_015278
(Aerococcus urinae ACS-120-V-Col10a)

1e-61

59) HMPREF0946_01874
( YP_008477788.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_022196
(Fusobacterium sp. 3_1_36A2)

1e-61

60) CIY_04240
( YP_007818436.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021031
(Butyrivibrio fibrisolvens 16/4)

1e-61

61) nadC
( YP_878597.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008593
(Clostridium novyi NT)

2e-61

62) nadC
( YP_003215231.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013315
(Clostridium difficile CD196)

5e-61

63) nadC
( YP_003218740.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013316
(Clostridium difficile R20291)

5e-61

64) ERE_20810
( YP_007842787.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021044
(Eubacterium rectale M104/1)

1e-60

65) nadC
( YP_001088882.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_009089
(Clostridium difficile 630)

7e-61

66) EUBREC_1035
( YP_002936931.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012781
(Eubacterium rectale ATCC 33656)

8e-61

67) EUR_20660
( YP_007773201.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021010
(Eubacterium rectale DSM 17629)

8e-61

68) nadC
( YP_001922148.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_010723
(Clostridium botulinum Alaska E43)

3e-60

69) nadC
( YP_005204424.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016826
(Streptococcus infantarius CJ18)

1e-59

70) CXIVA_12410
( YP_004708309.1 )

hypothetical protein

NC_015737
(Clostridium sp. SY8519)

7e-60

71) nadC
( YP_007453906.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_020291
(Clostridium saccharoperbutylacetonicum N1-4(HMT))

9e-60

72) CK5_33430
( YP_007806522.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021022
([Ruminococcus] obeum A2-162)

5e-59

73) KE3_1777
( YP_008357044.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021900
(Streptococcus lutetiensis 033)

3e-58

74) nadC
( YP_001781085.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010516
(Clostridium botulinum Okra)

4e-58

75) nadC
( YP_002862337.1 )

nicotinate-nucleotide diphosphorylase

NC_012658
(Clostridium botulinum 657)

4e-58

76) nadC
( YP_001383798.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009697
(Clostridium botulinum ATCC 19397)

4e-58

77) nadC
( YP_001253960.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009495
(Clostridium botulinum ATCC 3502)

4e-58

78) nadC
( YP_001387348.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009698
(Clostridium botulinum Hall)

4e-58

79) H04402_01516
( YP_005678066.1 )

quinolinate phosphoribosyltransferase

NC_017299
(Clostridium botulinum H04402 065)

6e-58

80) nadC
( YP_004288803.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_015215
(Streptococcus gallolyticus ATCC BAA-2069)

6e-58

81) nadC
( YP_006034733.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017576
(Streptococcus gallolyticus ATCC 43143)

7e-58

82) nadC
( YP_003431345.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013798
(Streptococcus gallolyticus UCN34)

7e-58

83) Clole_1593
( YP_004308516.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015275
(Clostridium lentocellum DSM 5427)

8e-58

84) nadC
( YP_004559866.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015600
(Streptococcus pasteurianus ATCC 43144)

9e-58

85) Cbei_0794
( YP_001307934.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009617
(Clostridium beijerinckii NCIMB 8052)

1e-57

86) nadC
( YP_005674443.1 )

nicotinate-nucleotide diphosphorylase

NC_017297
(Clostridium botulinum 230613)

2e-57

87) nadC
( YP_001390795.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009699
(Clostridium botulinum Langeland)

2e-57

88) nadC
( YP_006720951.1 )

quinolinate phosphoribosyltransferase, decarboxylating

NC_007517
(Geobacter metallireducens GS-15)

4e-57

89) RHOM_07325
( YP_004838510.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015977
(Roseburia hominis A2-183)

5e-57

90) Olsu_1386
( YP_003801369.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014363
(Olsenella uli DSM 7084)

6e-57

91) GM18_1909
( YP_004198648.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014973
(Geobacter sp. M18)

9e-57

92) nadC
( YP_005270402.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016894
(Acetobacterium woodii DSM 1030)

6e-56

93) nadC
( NP_561312.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003366
(Clostridium perfringens 13)

7e-56

94) nadC
( YP_005095428.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_016749
(Streptococcus macedonicus ACA-DC 198)

8e-56

95) nadC
( YP_694841.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008261
(Clostridium perfringens ATCC 13124)

8e-56

96) nadC
( YP_002139129.1 )

quinolinate phosphoribosyltransferase (decarboxylating)

NC_011146
(Geobacter bemidjiensis Bem)

2e-55

97) nadC
( YP_697707.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008262
(Clostridium perfringens SM101)

3e-55

98) GM21_1902
( YP_003021713.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012918
(Geobacter sp. M21)

4e-55

99) EC1_17550
( YP_007798638.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021019
(Eubacterium cylindroides T2-87)

5e-55

100) nadC
( YP_002803801.1 )

nicotinate-nucleotide diphosphorylase

NC_012563
(Clostridium botulinum Kyoto)

6e-55

101) Clocl_4213
( YP_005048563.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016627
(Clostridium clariflavum DSM 19732)

2e-54

102) nadC
( YP_001786870.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010520
(Clostridium botulinum Loch Maree)

3e-54

103) EUBELI_01429
( YP_002930869.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012778
(Eubacterium eligens ATCC 27750)

4e-54

104) MELS_2154
( YP_004767198.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015873
(Megasphaera elsdenii DSM 20460)

1e-53

105) TherJR_0219
( YP_003639008.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014152
(Thermincola potens JR)

2e-53

106) nadC
( YP_006921328.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018870
(Thermacetogenium phaeum DSM 12270)

3e-53

107) Cthe_2354
( YP_001038749.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009012
(Clostridium thermocellum ATCC 27405)

1e-52

108) Clo1313_3017
( YP_005689446.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017304
(Clostridium thermocellum DSM 1313)

1e-52

109) Ilyop_2323
( YP_003968431.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014633
(Ilyobacter polytropus DSM 2926)

2e-51

110) nadC
( NP_347659.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003030
(Clostridium acetobutylicum ATCC 824)

4e-50

111) nadC
( YP_004635688.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015687
(Clostridium acetobutylicum DSM 1731)

4e-50

112) nadC
( YP_005670169.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_017295
(Clostridium acetobutylicum EA 2018)

4e-50

113) Adeg_1872
( YP_003239803.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013385
(Ammonifex degensii KC4)

5e-50

114) CCALI_00718
( YP_008088684.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_021487
(Chthonomonas calidirosea T49)

5e-50

115) Calni_1310
( YP_004051381.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014758
(Calditerrivibrio nitroreducens DSM 19672)

6e-50

116) Acear_1082
( YP_003827670.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014378
(Acetohalobium arabaticum DSM 5501)

7e-50

117) nadC
( YP_007374271.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020134
(Clostridium stercorarium DSM 8532)

7e-50

118) Clst_2604
( YP_007680631.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020887
(Clostridium stercorarium DSM 8532)

7e-50

119) Despr_3036
( YP_004196460.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014972
(Desulfobulbus propionicus DSM 2032)

9e-50

120) Desca_0158
( YP_004495974.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015565
(Desulfotomaculum carboxydivorans CO-1-SRB)

9e-50

121) Desru_0243
( YP_004543827.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015589
(Desulfotomaculum ruminis DSM 2154)

2e-49

122) Btus_0100
( YP_003588022.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014098
(Kyrpidia tusciae DSM 2912)

3e-49

123) BN69_0372
( YP_006590474.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_018485
(Methylocystis sp. SC2)

3e-49

124) Dred_0165
( YP_001111539.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009253
(Desulfotomaculum reducens MI-1)

4e-49

125) Desdi_0090
( YP_007219059.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019903
(Desulfitobacterium dichloroeliminans LMG P-21439)

4e-49

126) Syn7502_03497
( YP_007107474.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019702
(Synechococcus sp. PCC 7502)

5e-49

127) nadC
( YP_006890928.1 )

quinolinate phosphoribosyltransferase, decarboxylating

NC_017454
(Geobacter sulfurreducens KN400)

7e-49

128) nadC
( NP_952985.1 )

quinolinate phosphoribosyltransferase, decarboxylating

NC_002939
(Geobacter sulfurreducens PCA)

7e-49

129) Geob_2383
( YP_002537838.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011979
(Geobacter daltonii FRC-32)

1e-48

130) Glov_1316
( YP_001951557.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010814
(Geobacter lovleyi SZ)

1e-48

131) nadC
( YP_006786950.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_018664
(Clostridium acidurici 9a)

1e-48

132) Gura_2818
( YP_001231564.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009483
(Geobacter uraniireducens Rf4)

2e-48

133) Pse7367_2252
( YP_007102943.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019701
(Pseudanabaena sp. PCC 7367)

9e-49

134) MROS_0953
( YP_006527207.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018178
(Melioribacter roseus P3M-2)

9e-49

135) nadC
( YP_005433606.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_017068
(Selenomonas ruminantium TAM6421)

4e-48

136) nadC
( YP_002769614.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012491
(Brevibacillus brevis NBRC 100599)

6e-48

137) NadC
( YP_001210777.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009454
(Pelotomaculum thermopropionicum SI)

8e-48

138) Desgi_0291
( YP_007943553.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021184
(Desulfotomaculum gibsoniae DSM 7213)

8e-48

139) Rpdx1_1218
( YP_004107577.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014834
(Rhodopseudomonas palustris DX-1)

2e-47

140) Halsa_0362
( YP_003994191.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014654
(Halanaerobium hydrogeniformans sapolanicus)

2e-47

141) RPC_4340
( YP_534182.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007925
(Rhodopseudomonas palustris BisB18)

3e-47

142) Acfer_0928
( YP_003398628.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013740
(Acidaminococcus fermentans DSM 20731)

4e-47

143) nadC
( YP_001679899.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010337
(Heliobacterium modesticaldum Ice1)

4e-47

144) nadC
( NP_923834.1 )

nicotinate-nucleotide pyrophosphorylase

NC_005125
(Gloeobacter violaceus PCC 7421)

6e-47

145) RoseRS_0439
( YP_001274818.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009523
(Roseiflexus sp. RS-1)

1e-46

146) Dtur_0752
( YP_002352648.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011661
(Dictyoglomus turgidum DSM 6724)

6e-47

147) nadC
( NP_769180.1 )

nicotinate-mononucleotide pyrophosphorylase

NC_004463
(Bradyrhizobium japonicum USDA 110)

7e-47

148) nadC
( YP_008101303.1 )

quinolinate phosphoribosyltransferase

NC_021499
(Pseudomonas resinovorans NBRC 106553)

1e-46

149) nadC
( YP_003565089.1 )

nicotinate-nucleotide diphosphorylase

NC_014019
(Bacillus megaterium QM B1551)

2e-46

150) AciX8_1439
( YP_005056812.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016631
(Granulicella mallensis MP5ACTX8)

2e-46

151) PGN_0534
( YP_001928650.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010729
(Porphyromonas gingivalis ATCC 33277)

3e-46

152) Halha_1152
( YP_007315194.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019978
(Halobacteroides halobius DSM 5150)

3e-46

153) nadC
( NP_946404.1 )

nicotinate-nucleotide pyrophosphorylase

NC_005296
(Rhodopseudomonas palustris CGA009)

3e-46

154) nadC
( YP_003599811.1 )

nicotinate-nucleotide diphosphorylase

NC_014103
(Bacillus megaterium DSM 319)

5e-46

155) SYN_02885
( YP_461989.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007759
(Syntrophus aciditrophicus SB)

5e-46

156) UWK_00179
( YP_007466418.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_020304
(Desulfocapsa sulfexigens DSM 10523)

6e-46

157) C624_06120
( YP_008065933.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021351
(Corynebacterium glutamicum SCgG1)

6e-46

158) C629_06120
( YP_008068956.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021352
(Corynebacterium glutamicum SCgG2)

6e-46

159) Desaci_1883
( YP_006466192.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_018068
(Desulfosporosinus acidiphilus SJ4)

7e-46

160) nadC
( NP_905708.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002950
(Porphyromonas gingivalis W83)

7e-46

161) Rpal_1245
( YP_001990260.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011004
(Rhodopseudomonas palustris TIE-1)

7e-46

162) Rru_A1432
( YP_426520.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007643
(Rhodospirillum rubrum ATCC 11170)

8e-46

163) F11_07395
( YP_006047746.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017584
(Rhodospirillum rubrum F11)

8e-46

164) Desor_0089
( YP_004968362.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016584
(Desulfosporosinus orientis DSM 765)

9e-46

165) nadC
( YP_004509453.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015571
(Porphyromonas gingivalis TDC60)

1e-45

166) nadC
( YP_474410.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007775
(Synechococcus sp. JA-3-3Ab)

1e-45

167) Pjdr2_0070
( YP_003008837.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012914
(Paenibacillus sp. JDR-2)

1e-45

168) nadC
( YP_003780601.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014328
(Clostridium ljungdahlii ATCC 49587)

1e-45

169) Anacy_1478
( YP_007155897.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_019771
(Anabaena cylindrica PCC 7122)

2e-45

170) nadC
( YP_001394151.1 )

hypothetical protein

NC_009706
(Clostridium kluyveri DSM 555)

2e-45

171) CKR_0671
( YP_002471136.1 )

hypothetical protein

NC_011837
(Clostridium kluyveri NBRC 12016)

2e-45

172) Flexsi_1006
( YP_004603233.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015672
(Flexistipes sinusarabici DSM 4947)

2e-45

173) nadC
( YP_003414335.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013766
(Listeria monocytogenes 08-5578)

2e-45

174) nadC
( YP_003417380.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013768
(Listeria monocytogenes 08-5923)

2e-45

175) Ccel_3478
( YP_002507746.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011898
(Clostridium cellulolyticum H10)

3e-45

176) Clo1100_4098
( YP_005150003.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016791
(Clostridium sp. BNL1100)

3e-45

177) Rumal_3121
( YP_004106220.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014833
(Ruminococcus albus 7)

5e-45

178) nadC
( YP_759418.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008358
(Hyphomonas neptunium ATCC 15444)

7e-45

179) nadC
( YP_002730179.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_012440
(Persephonella marina EX-H1)

1e-44

180) nadC
( NP_390664.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_000964
(Bacillus subtilis 168)

1e-44

181) nadC
( YP_007534774.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_020507
(Bacillus subtilis 6051-HGW)

1e-44

182) nadC
( YP_006630886.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018520
(Bacillus subtilis QB928)

1e-44

183) Npun_F5252
( YP_001868521.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010628
(Nostoc punctiforme PCC 73102)

1e-44

184) nadC
( YP_933583.1 )

nicotinate-nucleotide diphosphorylase

NC_008702
(Azoarcus sp. BH72)

1e-44

185) nadC
( YP_005950164.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017538
(Oligotropha carboxidovorans OM4)

1e-44

186) nadC
( YP_004632100.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015684
(Oligotropha carboxidovorans OM5)

1e-44

187) nadC
( YP_002289917.1 )

nicotinate-nucleotide diphosphorylase

NC_011386
(Oligotropha carboxidovorans OM5; ATCC 49405)

1e-44

188) nadC
( YP_007337004.1 )

nicotinate-nucleotide diphosphorylase

NC_020062
(Rhizobium tropici CIAT 899)

1e-44

189) Caur_0893
( YP_001634515.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010175
(Chloroflexus aurantiacus J-10-fl)

8e-45

190) Chy400_0971
( YP_002568720.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012032
(Chloroflexus sp. Y-400-fl)

8e-45

191) Cgl1068
( NP_600296.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003450
(Corynebacterium glutamicum ATCC 13032)

9e-45

192) NadC
( YP_007560282.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020519
(Corynebacterium glutamicum ATCC 13032)

9e-45

193) nadC
( YP_225359.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006958
(Corynebacterium glutamicum ATCC 13032)

9e-45

194) nadC
( YP_008401196.1 )

putative nicotinate-nucleotide pyrophosphorylase

NC_022040
(Corynebacterium glutamicum MB001)

9e-45

195) nadC
( YP_003936824.1 )

quinolinate phosphoribosyltransferase

NC_014614
(Clostridium sticklandii DSM 519)

2e-44

196) nadC
( YP_003868500.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014483
(Paenibacillus polymyxa E681)

2e-44

197) nadC
( YP_005957700.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017542
(Paenibacillus polymyxa M1)

2e-44

198) PPSC2_c0062
( YP_003944290.1 )

nicotinate-nucleotide diphosphorylase

NC_014622
(Paenibacillus polymyxa SC2)

2e-44

199) cgR_1151
( YP_001138031.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009342
(Corynebacterium glutamicum R)

2e-44

200) DP1795
( YP_065531.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006138
(Desulfotalea psychrophila LSv54)

3e-44

201) nadC
( YP_005080155.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_016642
(Pseudovibrio sp. FO-BEG1)

3e-44

202) nadC
( YP_006329662.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017912
(Bacillus amyloliquefaciens Y2)

3e-44

203) BSn5_04740
( YP_004204603.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014976
(Bacillus subtilis BSn5)

3e-44

204) Cyast_1448
( YP_007165061.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019778
(Cyanobacterium stanieri PCC 7202)

3e-44

205) nadC
( YP_005557753.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017195
(Bacillus subtilis RO-NN-1)

4e-44

206) A7A1_0427
( YP_007208710.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_019896
(Bacillus subtilis BSP1)

4e-44

207) Calkro_1486
( YP_004024161.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014720
(Caldicellulosiruptor kronotskyensis 2002)

4e-44

208) Riv7116_5264
( YP_007058194.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019678
(Rivularia sp. PCC 7116)

4e-44

209) nadC
( YP_787436.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010645
(Bordetella avium 197N)

4e-44

210) nadC
( YP_005422038.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017061
(Bacillus amyloliquefaciens YAU B9601-Y2)

5e-44

211) nadC
( YP_005561976.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017196
(Bacillus subtilis BEST195)

6e-44

212) nadC
( YP_001422082.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009725
(Bacillus amyloliquefaciens FZB42)

1e-43

213) GYMC10_0058
( YP_003240175.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013406
(Paenibacillus sp. Y412MC10)

1e-43

214) Calhy_1511
( YP_003992597.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014652
(Caldicellulosiruptor hydrothermalis 108)

1e-43

215) B938_12875
( YP_007187257.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019842
(Bacillus amyloliquefaciens AS43.3)

7e-44

216) Athe_1214
( YP_002573087.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012034
(Caldicellulosiruptor bescii DSM 6725)

7e-44

217) nadC
( YP_361169.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007503
(Carboxydothermus hydrogenoformans Z-2901)

7e-44

218) Sgly_0223
( YP_004264595.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015172
(Syntrophobotulus glycolicus DSM 8271)

7e-44

219) Ppro_0653
( YP_900342.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008609
(Pelobacter propionicus DSM 2379)

8e-44

220) nadC
( YP_008421853.1 )

nicotinate-nucleotide pyrophosphorylase

NC_022081
(Bacillus amyloliquefaciens UCMB5113)

8e-44

221) Csac_1779
( YP_001180555.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009437
(Caldicellulosiruptor saccharolyticus DSM 8903)

8e-44

222) HPL003_07785
( YP_005074543.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016641
(Paenibacillus terrae HPL-003)

8e-44

223) nadC
( YP_007498121.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020410
(Bacillus amyloliquefaciens UCMB5036)

9e-44

224) nadC
( YP_004676761.1 )

nicotinate-mononucleotide pyrophosphorylase

NC_015717
(Hyphomicrobium sp. MC1)

9e-44

225) nadC
( YP_003495756.1 )

nicotinate-nucleotide pyrophosphorylase carboxylating

NC_013939
(Deferribacter desulfuricans SSM1)

1e-43

226) KSO_006605
( YP_007444699.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020272
(Bacillus amyloliquefaciens IT-45)

2e-43

227) I653_13270
( YP_007663409.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020832
(subtilis subtilis BAB-1)

2e-43

228) Slip_0141
( YP_003701506.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014220
(Syntrophothermus lipocalidus DSM 12680)

2e-43

229) RBR_10270
( YP_007781112.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_021013
(Ruminococcus bromii L2-63)

2e-43

230) Fisuc_2255
( YP_003250323.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013410
(Fibrobacter succinogenes S85)

2e-43

231) nadC
( YP_005822610.1 )

nicotinate-nucleotide diphosphorylase

NC_017448
(Fibrobacter succinogenes S85)

2e-43

232) nadC
( YP_005131236.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016784
(Bacillus amyloliquefaciens CAU B946)

3e-43

233) nadC
( YP_008413609.1 )

nicotinate-nucleotide pyrophosphorylase

NC_022075
(Bacillus amyloliquefaciens UCMB-5033)

3e-43

234) Cri9333_4696
( YP_007144985.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019753
(Crinalium epipsammum PCC 9333)

3e-43

235) Cagg_1774
( YP_002463110.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011831
(Chloroflexus aggregans DSM 9485)

3e-43

236) nadC
( YP_001656869.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010296
(Microcystis aeruginosa NIES-843)

3e-43

237) nadC
( YP_003867044.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014479
(Bacillus subtilis W23)

4e-43

238) COB47_1342
( YP_003840620.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014392
(Caldicellulosiruptor obsidiansis OB47)

4e-43

239) Bfae_03770
( YP_003153841.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013172
(Brachybacterium faecium DSM 4810)

4e-43

240) Lepto7376_3197
( YP_007072260.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019683
(Leptolyngbya sp. PCC 7376)

4e-43

241) nadC
( YP_004575092.1 )

quinolinate phosphoribosyltransferase

NC_015635
(Microlunatus phosphovorus NM-1)

4e-43

242) cur_0075
( YP_001799469.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010545
(Corynebacterium urealyticum DSM 7109)

1e-42

243) nadC
( YP_007415918.1 )

putative nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_020230
(Corynebacterium urealyticum DSM 7111)

1e-42

244) Mmc1_1475
( YP_865390.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008576
(Magnetococcus marinus MC-1)

5e-43

245) PCC8801_4217
( YP_002374300.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011726
(Cyanothece sp. PCC 8801)

6e-43

246) Cyan8802_4256
( YP_003139877.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013161
(Cyanothece sp. PCC 8802)

6e-43

247) MY9_2769
( YP_006232558.1 )

NadC

NC_017743
(Bacillus sp. JS)

9e-43

248) Rcas_1005
( YP_001431131.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009767
(Roseiflexus castenholzii DSM 13941)

9e-43

249) Cha6605_0687
( YP_007095486.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019697
(Chamaesiphon minutus PCC 6605)

9e-43

250) PB2503_02572
( YP_003853732.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014414
(Parvularcula bermudensis HTCC2503)

1e-42

251) nadC
( YP_681846.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008209
(Roseobacter denitrificans OCh 114)

1e-42

252) DCF50_p351
( YP_006912342.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018867
(Dehalobacter sp. CF)

1e-42

253) DHBDCA_p291
( YP_006909304.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018866
(Dehalobacter sp. DCA)

1e-42

254) Terro_1520
( YP_006421162.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018014
(Terriglobus roseus DSM 18391)

1e-42

255) Syn6312_3664
( YP_007063219.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019680
(Synechococcus sp. PCC 6312)

2e-42

256) Rvan_0617
( YP_004010994.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014664
(Rhodomicrobium vannielii ATCC 17100)

2e-42

257) nadC
( YP_003921188.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014551
(Bacillus amyloliquefaciens DSM 7)

2e-42

258) Calow_1005
( YP_004002368.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014657
(Caldicellulosiruptor owensensis OL)

2e-42

259) Ple7327_1506
( YP_007080440.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019689
(Pleurocapsa minor PCC 7327)

2e-42

260) nadC
( YP_006760518.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating) NadC

NC_018645
(Desulfobacula toluolica Tol2)

2e-42

261) Dole_1728
( YP_001529609.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009943
(Desulfococcus oleovorans Hxd3)

2e-42

262) mll5833
( NP_106427.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002678
(Mesorhizobium loti MAFF303099)

2e-42

263) nadC
( YP_004692090.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_015730
(Roseobacter litoralis Och 149)

2e-42

264) Tthe_0548
( YP_003851194.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014410
(Thermoanaerobacterium thermosaccharolyticum DSM 571)

2e-42

265) TtJL18_1062
( YP_006058744.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017587
(Thermus thermophilus JL-18)

3e-42

266) Cal6303_0642
( YP_007135686.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019751
(Calothrix sp. PCC 6303)

3e-42

267) nadC
( YP_005546630.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017190
(Bacillus amyloliquefaciens LL3)

3e-42

268) nadC
( YP_005542387.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017188
(Bacillus amyloliquefaciens TA208)

4e-42

269) nadC
( YP_005550770.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017191
(Bacillus amyloliquefaciens XH7)

4e-42

270) Psyr_0815
( YP_233911.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007005
(Pseudomonas syringae B728a)

4e-42

271) Dtox_2252
( YP_003191689.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013216
(Desulfotomaculum acetoxidans DSM 771)

4e-42

272) nadC
( YP_004878262.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016047
(Bacillus subtilis TU-B-10)

5e-42

273) Dalk_0496
( YP_002429671.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011768
(Desulfatibacillum alkenivorans AK-01)

5e-42

274) GEI7407_0212
( YP_007107769.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019703
(Geitlerinema sp. PCC 7407)

7e-42

275) nadC
( YP_003976760.1 )

nicotinate-nucleotide diphosphorylase

NC_014640
(Achromobacter xylosoxidans A8)

7e-42

276) Dgeo_1163
( YP_604629.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008025
(Deinococcus geothermalis DSM 11300)

1e-41

277) Rleg2_6035
( YP_002278305.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011366
(Rhizobium leguminosarum WSM2304)

1e-41

278) nadC
( YP_001518910.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009925
(Acaryochloris marina MBIC11017)

1e-41

279) Bind_3492
( YP_001834538.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010581
(Beijerinckia indica ATCC 9039)

1e-41

280) nadC; SCE94.32c
( NP_627589.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003888
(Streptomyces coelicolor A3(2))

1e-41

281) RUM_07150
( YP_007828921.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_021039
(Ruminococcus champanellensis 18P13)

9e-42

282) nadC
( NP_441715.1 )

nicotinate-nucleotide pyrophosphorylase

NC_000911
(Synechocystis sp. PCC 6803)

9e-42

283) nadC
( YP_005383583.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017038
(Synechocystis sp. PCC 6803)

9e-42

284) nadC
( YP_005386752.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017039
(Synechocystis sp. PCC 6803)

9e-42

285) nadC
( YP_005409459.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017052
(Synechocystis sp. PCC 6803)

9e-42

286) nadC
( YP_005651774.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017277
(Synechocystis sp. PCC 6803)

9e-42

287) nadC
( YP_007451597.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020286
(Synechocystis sp. PCC 6803)

9e-42

288) nadC
( YP_003489588.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_013929
(Streptomyces scabiei 87.22)

9e-42

289) Haur_3382
( YP_001546146.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009972
(Herpetosiphon aurantiacus DSM 785)

2e-41

290) Amet_0019
( YP_001317921.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009633
(Alkaliphilus metalliredigens QYMF)

2e-41

291) nadC
( YP_001487650.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009848
(Bacillus pumilus SAFR-032)

2e-41

292) Oscil6304_1800
( YP_007085398.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019693
(Oscillatoria acuminata PCC 6304)

2e-41

293) PputW619_4407
( YP_001751256.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010501
(Pseudomonas putida W619)

2e-41

294) Mesau_05630
( YP_007307307.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019973
(Mesorhizobium australicum WSM2073)

2e-41

295) Mesci_5579
( YP_004144723.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014923
(Mesorhizobium ciceri WSM1271)

2e-41

296) Mesop_6161
( YP_004614653.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015675
(Mesorhizobium opportunistum WSM2075)

2e-41

297) nadC
( NP_790787.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004578
(Pseudomonas syringae DC3000)

2e-41

298) nadC
( YP_771650.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008384
(Rhizobium leguminosarum 3841)

3e-41

299) nadC
( YP_005369295.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017030
(Corallococcus coralloides DSM 2259)

3e-41

300) GTNG_2530
( YP_001126620.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009328
(Geobacillus thermodenitrificans NG80-2)

3e-41

301) Desku_3227
( YP_004518517.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015573
(Desulfotomaculum kuznetsovii DSM 6115)

3e-41

302) Calkr_1195
( YP_004026316.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014721
(Caldicellulosiruptor kristjanssonii 177R1B)

4e-41

303) Plav_0732
( YP_001412012.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009719
(Parvibaculum lavamentivorans DS-1)

4e-41

304) nadC
( YP_001985969.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010998
(Rhizobium etli CIAT 652)

5e-41

305) nadC
( YP_005069001.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016640
(Arthrospira platensis NIES-39)

6e-41

306) nadC
( YP_002250470.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011297
(Dictyoglomus thermophilum H-6-12)

1e-40

307) Rleg_7190
( YP_002985159.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012858
(Rhizobium leguminosarum WSM1325)

1e-40

308) M062_23805
( YP_008135159.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021577
(Pseudomonas aeruginosa RP73)

1e-40

309) nadC
( YP_003465239.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013891
(Listeria seeligeri SLCC3954)

1e-40

310) nadC
( YP_002521837.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011959
(Thermomicrobium roseum DSM 5159)

2e-40

311) Ethha_0040
( YP_004090362.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014828
(Ethanoligenens harbinense YUAN-3)

7e-41

312) nadC
( YP_003898643.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014532
(Halomonas elongata DSM 2581)

7e-41

313) Cycma_1124
( YP_004773127.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015914
(Cyclobacterium marinum DSM 745)

7e-41

314) nadC
( NP_385202.1 )

nicotinate-nucleotide pyrophosphorylase carboxylating protein

NC_003047
(Sinorhizobium meliloti 1021)

7e-41

315) nadC
( YP_007574360.1 )

putative nicotinate-nucleotide pyrophosphorylase carboxylating protein

NC_020528
(Sinorhizobium meliloti 2011)

7e-41

316) SinmeB_0718
( YP_005712896.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017322
(Sinorhizobium meliloti BL225C)

7e-41

317) C770_GR4Chr1104
( YP_007189664.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019845
(Sinorhizobium meliloti GR4)

7e-41

318) nadC
( YP_005719300.1 )

nicotinate-nucleotide pyrophosphorylase carboxylating protein

NC_017325
(Sinorhizobium meliloti SM11)

7e-41

319) nadC
( YP_002131447.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011144
(Phenylobacterium zucineum HLK1)

8e-41

320) mll9102
( NP_085664.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002679
(Mesorhizobium loti MAFF303099)

8e-41

321) Niako_6865
( YP_005012490.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016609
(Niastella koreensis GR20-10)

8e-41

322) nadC
( YP_003916524.1 )

nicotinate-nucleotide diphosphorylase

NC_014550
(Arthrobacter arilaitensis Re117)

1e-40

323) nadC
( YP_007552229.1 )

nicotinate-nucleotide diphosphorylase

NC_020516
(Azoarcus sp. KH32C)

1e-40

324) nadC
( YP_005430231.1 )

quinolinate phosphoribosyltransferase; Nicotinate-nucleotide pyrophosphorylase

NC_017067
(Marinobacter hydrocarbonoclasticus ATCC 49840)

1e-40

325) Meso_2555
( YP_675104.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008254
(Chelativorans sp. BNC1)

2e-40

326) Cal7507_6007
( YP_007069150.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019682
(Calothrix sp. PCC 7507)

2e-40

327) Calla_0602
( YP_004798231.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015949
(Caldicellulosiruptor lactoaceticus 6A)

2e-40

328) Daci_1541
( YP_001562570.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010002
(Delftia acidovorans SPH-1)

2e-40

329) Fluta_0712
( YP_004343554.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015321
(Fluviicola taffensis DSM 16823)

2e-40

330) lin2132
( NP_471466.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003212
(Listeria innocua Clip11262)

2e-40

331) Thicy_0694
( YP_004536945.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015581
(Thioalkalimicrobium cyclicum ALM1)

2e-40

332) Daud_0123
( YP_001716323.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010424
(Candidatus Desulforudis audaxviator MP104C)

3e-40

333) Nham_2821
( YP_578052.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007964
(Nitrobacter hamburgensis X14)

3e-40

334) Sta7437_4275
( YP_007134712.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_019748
(Stanieria cyanosphaera PCC 7437)

3e-40

335) Thethe_00540
( YP_007297933.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_019970
(Thermoanaerobacterium thermosaccharolyticum M0795)

3e-40

336) Maqu_0952
( YP_958235.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008740
(Marinobacter aquaeolei VT8)

3e-40

337) AciPR4_4253
( YP_004184990.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014963
(Terriglobus saanensis SP1PR4)

4e-40

338) DelCs14_4992
( YP_004490318.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015563
(Delftia sp. Cs1-4)

4e-40

339) AMBAS45_14570
( YP_006803858.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018679
(Alteromonas macleodii Balearic Sea AD45)

5e-40

340) MYSTI_04945
( YP_007361917.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020126
(Myxococcus stipitatus DSM 14675)

5e-40

341) Marky_2090
( YP_004368925.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015387
(Marinithermus hydrothermalis DSM 14884)

6e-40

342) MASE_14050
( YP_006748868.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018632
(Alteromonas macleodii ATCC 27126)

6e-40

343) nadC
( YP_005979331.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017549
(Pseudomonas aeruginosa NCGM2.S1)

6e-40

344) ES1_08710
( YP_007839475.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_021043
(Eubacterium siraeum V10Sc8a)

7e-40

345) PADK2_23550
( YP_006484675.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018080
(Pseudomonas aeruginosa DK2)

7e-40

346) CC_2915
( NP_421709.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002696
(Caulobacter crescentus CB15)

8e-40

347) CCNA_03009
( YP_002518382.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011916
(Caulobacter crescentus NA1000)

8e-40

348) EUS_21910
( YP_007776099.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_021011
(Eubacterium siraeum 70/3)

9e-40

349) Glaag_1005
( YP_004433234.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015497
(Glaciecola sp. 4H-3-7+YE-5)

9e-40

350) nadC
( YP_004225903.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015125
(Microbacterium testaceum StLB037)

9e-40

351) Thexy_0431
( YP_004470155.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015555
(Thermoanaerobacterium xylanolyticum LX-11)

1e-39

352) GbCGDNIH1_0642
( YP_744463.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008343
(Granulibacter bethesdensis CGDNIH1)

1e-39

353) AMEC673_14375
( YP_006799934.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018678
(Alteromonas macleodii English Channel 673)

1e-39

354) nadC
( YP_002963867.1 )

nicotinate-mononucleotide pyrophosphorylase

NC_012808
(Methylobacterium extorquens AM1)

1e-39

355) Odosp_0838
( YP_004252095.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015160
(Odoribacter splanchnicus DSM 220712)

1e-39

356) G655_23255
( YP_007711489.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020912
(Pseudomonas aeruginosa B136-33)

1e-39

357) nadC
( YP_002442486.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011770
(Pseudomonas aeruginosa LESB58)

1e-39

358) nadC
( YP_005977198.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017548
(Pseudomonas aeruginosa M18)

1e-39

359) nadC
( NP_253214.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002516
(Pseudomonas aeruginosa PAO1)

1e-39

360) nadC
( YP_792869.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008463
(Pseudomonas aeruginosa UCBPP-PA14)

1e-39

361) Pcryo_0602
( YP_579869.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007969
(Psychrobacter cryohalolentis K5)

1e-39

362) PSYCG_03340
( YP_008162545.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021661
(Psychrobacter sp. G)

1e-39

363) SYO3AOP1_0647
( YP_001930837.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010730
(Sulfurihydrogenibium sp. YO3AOP1)

2e-39

364) Mext_2646
( YP_001640109.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010172
(Methylobacterium extorquens PA1)

2e-39

365) SCAT_2627
( YP_004912137.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016111
(Streptomyces cattleya NRRL 8057)

3e-39

366) SCATT_26090
( YP_006054502.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017586
(Streptomyces cattleya NRRL 8057)

3e-39

367) Swol_0107
( YP_752834.1 )

nicotinate-nucleotide diphosphorylase

NC_008346
(Syntrophomonas wolfei Goettingen)

9e-40

368) nadC
( NP_242085.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002570
(Bacillus halodurans C-125)

2e-39

369) Cyan7822_4212
( YP_003889405.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014501
(Cyanothece sp. PCC 7822)

2e-39

370) EAT1b_2689
( YP_002887050.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012673
(Exiguobacterium sp. AT1b)

2e-39

371) Bacsa_3371
( YP_004260369.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015164
(Bacteroides salanitronis DSM 18170)

2e-39

372) SCD_n01136
( YP_008546002.1 )

nicotinate-nucleotide pyrophosphorylase

NC_022357
(Sulfuricella denitrificans skB26)

2e-39

373) Cylst_0269
( YP_007145320.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_019757
(Cylindrospermum stagnale PCC 7417)

3e-39

374) Geoth_1040
( YP_004587119.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015660
(Geobacillus thermoglucosidasius C56-YS93)

3e-39

375) nadC
( YP_632630.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008095
(Myxococcus xanthus DK 1622)

3e-39

376) Cpin_0473
( YP_003120172.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013132
(Chitinophaga pinensis DSM 2588)

3e-39

377) ambt_02290
( YP_004465814.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015554
(Alteromonas sp. SN2)

3e-39

378) LILAB_30425
( YP_004669044.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015711
(Myxococcus fulvus HW-1)

4e-39

379) SBI_05945
( YP_004964196.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016582
(Streptomyces bingchenggensis BCW-1)

5e-39

380) nadC
( YP_008115533.1 )

quinolinate phosphoribosyltransferase

NC_021505
(Pseudomonas putida NBRC 14164)

4e-39

381) nadC
( YP_001741891.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020449
(Candidatus Cloacamonas acidaminovorans Evry)

5e-39

382) Mbur_1682
( YP_566326.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_007955
(Methanococcoides burtonii DSM 6242)

5e-39

383) nadC
( YP_005188106.1 )

nicotinate-mononucleotide pyrophosphorylase

NC_016812
(Sinorhizobium fredii HH103)

5e-39

384) nadC
( YP_003954419.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014623
(Stigmatella aurantiaca DW4/3-1)

6e-39

385) nadC
( YP_044866.1 )

nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

NC_005966
(Acinetobacter sp. ADP1)

7e-39

386) TTHA0985
( YP_144251.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006461
(Thermus thermophilus HB8)

1e-38

387) O159_19020
( YP_008580494.1 )

nicotinate-nucleotide pyrophosphorylase

NC_022438
(Leifsonia xyli DSM 46306)

1e-38

388) Xcel_0348
( YP_003324945.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013530
(Xylanimonas cellulosilytica DSM 15894)

1e-38

389) BATR1942_11695
( YP_003974201.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014639
(Bacillus atrophaeus 1942)

1e-38

390) nadC
( YP_273122.1 )

nicotinate-nucleotide pyrophosphorylase

NC_005773
(Pseudomonas syringae 1448A)

1e-38

391) MADE_1015005
( YP_004428133.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011138
(Alteromonas macleodii Deep ecotype)

1e-38

392) nadC
( YP_006714251.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006322
(Bacillus licheniformis DSM 13)

1e-38

393) nadC
( YP_080057.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006270
(Bacillus licheniformis DSM 13)

1e-38

394) GY4MC1_0970
( YP_003988395.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014650
(Geobacillus sp. Y4.1MC1)

1e-38

395) Aazo_2134
( YP_003721278.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014248
(Nostoc azollae 0708)

1e-38

396) Nwi_2426
( YP_319032.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007406
(Nitrobacter winogradskyi Nb-255)

1e-38

397) Rfer_1318
( YP_522583.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007908
(Rhodoferax ferrireducens T118)

2e-38

398) Dacet_1743
( YP_003504463.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013943
(Denitrovibrio acetiphilus DSM 12809)

7e-39

399) Tcr_1367
( YP_391636.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007520
(Thiomicrospira crunogena XCL-2)

7e-39

400) nadC
( YP_003884582.1 )

quinolinate phosphoribosyltransferase

NC_014500
(Dickeya dadantii 3937)

8e-39

401) nadC
( YP_263927.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007204
(Psychrobacter arcticus 273-4)

8e-39

402) DaAHT2_0818
( YP_003690141.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014216
(Desulfurivibrio alkaliphilus AHT2)

9e-39

403) Tsac_1151
( YP_006391763.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017992
(Thermoanaerobacterium saccharolyticum JW/SL-YS485)

2e-38

404) nadC
( YP_003797389.1 )

nicotinate-nucleotide diphosphorylase

NC_014355
(Candidatus Nitrospira defluvii )

2e-38

405) nadC
( YP_002248724.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011296
(Thermodesulfovibrio yellowstonii DSM 11347)

2e-38

406) GLX_02670
( YP_004867049.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016027
(Gluconacetobacter xylinus NBRC 3288)

2e-38

407) PCC7418_3121
( YP_007169454.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019779
(Halothece sp. PCC 7418)

2e-38

408) Poras_0265
( YP_004441387.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015501
(Porphyromonas asaccharolytica DSM 20707)

2e-38

409) nadC
( YP_062536.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006087
(Leifsonia xyli CTCB07)

3e-38

410) nadC
( YP_257983.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004129
(Pseudomonas protegens Pf-5)

3e-38

411) Desde_0126
( YP_006428413.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018017
(Desulfitobacterium dehalogenans ATCC 51507)

3e-38

412) amad1_15015
( YP_006977854.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019393
(Alteromonas macleodii AltDE1)

3e-38

413) I607_14315
( YP_008172906.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021710
(Alteromonas macleodii Ionian Sea U4)

3e-38

414) I876_14610
( YP_008197304.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021717
(Alteromonas macleodii Ionian Sea U7)

3e-38

415) I634_14555
( YP_008177008.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021712
(Alteromonas macleodii Ionian Sea U8)

3e-38

416) I636_14430
( YP_008184848.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021714
(Alteromonas macleodii Ionian Sea UM4b)

3e-38

417) I635_14985
( YP_008180912.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021713
(Alteromonas macleodii Ionian Sea UM7)

3e-38

418) TCCBUS3UF1_12200
( YP_005654337.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_017278
(Thermus sp. CCB_US3_UF1)

3e-38

419) Nos7524_3692
( YP_007077075.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019684
(Nostoc sp. PCC 7524)

3e-38

420) Dvul_1353
( YP_966798.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008751
(Desulfovibrio vulgaris DP4)

3e-38

421) nadC
( YP_011025.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002937
(Desulfovibrio vulgaris Hildenborough)

3e-38

422) Deval_1496
( YP_005702289.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017310
(Desulfovibrio vulgaris RCH1)

3e-38

423) Ftrac_2356
( YP_004054442.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014759
(Marivirga tractuosa DSM 4126)

3e-38

424) nadC
( YP_007998161.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021237
(Pseudomonas fluorescens CHA0)

4e-38

425) nadC
( YP_001733632.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010475
(Synechococcus sp. PCC 7002)

4e-38

426) I633_15505
( YP_008193522.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021716
(Alteromonas macleodii English Channel 615)

4e-38

427) TTC0621
( YP_004596.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_005835
(Thermus thermophilus HB27)

5e-38

428) nadC
( NP_213590.1 )

quinolinate phosphoribosyl transferase

NC_000918
(Aquifex aeolicus VF5)

5e-38

429) Tcur_4484
( YP_003302049.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013510
(Thermomonospora curvata DSM 43183)

5e-38

430) Xaut_1181
( YP_001416087.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009720
(Xanthobacter autotrophicus Py2)

5e-38

431) Dester_1111
( YP_004281807.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015185
(Desulfurobacterium thermolithotrophum DSM 11699)

6e-38

432) nadC
( NP_682503.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004113
(Thermosynechococcus elongatus BP-1)

6e-38

433) nadC
( YP_003574099.1 )

nicotinate-nucleotide diphosphorylase

NC_014033
(Prevotella ruminicola 23)

6e-38

434) Slin_5167
( YP_003389938.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013730
(Spirosoma linguale DSM 74)

6e-38

435) Osc7112_3279
( YP_007116078.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_019729
(Oscillatoria nigro-viridis PCC 7112)

1e-37

436) nadC
( YP_006717717.1 )

quinolinate phosphoribosyltransferase, decarboxylating

NC_007498
(Pelobacter carbinolicus DSM 2380)

1e-37

437) nadC
( YP_003626949.1 )

nicotinate-nucleotide diphosphorylase

NC_014147
(Moraxella catarrhalis RH4)

1e-37

438) nadC
( YP_006322309.1 )

nicotinate-nucleotide diphosphorylase

NC_017911
(Pseudomonas fluorescens A506)

1e-37

439) H045_00795
( YP_007395731.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020209
(Pseudomonas poae RE*1-1-14)

1e-37

440) nadC
( YP_891996.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008599
(Campylobacter fetus 82-40)

1e-37

441) Q7C_281
( YP_006292147.1 )

quinolinate phosphoribosyltransferase

NC_017856
(Methylophaga sp. JAM7)

7e-38

442) nadC
( YP_006396170.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018000
(Sinorhizobium fredii USDA 257)

7e-38

443) B841_01340
( YP_008370238.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021915
(Corynebacterium maris DSM 45190)

8e-38

444) AMBLS11_13955
( YP_006825815.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018692
(Alteromonas macleodii Black Sea 11)

9e-38

445) nadC
( YP_175044.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006582
(Bacillus clausii KSM-K16)

1e-37

446) GWCH70_2530
( YP_002950491.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012793
(Geobacillus sp. WCH70)

1e-37

447) Dret_1371
( YP_003198237.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013223
(Desulfohalobium retbaense DSM 5692)

2e-37

448) Hore_00640
( YP_002507820.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011899
(Halothermothrix orenii H 168)

2e-37

449) nadC
( YP_472601.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007765
(Rhizobium etli CFN 42)

2e-37

450) nadC-2
( YP_008367739.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating) 2

NC_021908
(Rhizobium etli Mim1)

2e-37

451) Desaf_2918
( YP_005052885.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016629
(Desulfovibrio africanus Walvis Bay)

2e-37

452) Pfl01_0785
( YP_346517.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007492
(Pseudomonas fluorescens Pf0-1)

2e-37

453) Synpcc7942_0951
( YP_399968.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007604
(Synechococcus elongatus PCC 7942)

2e-37

454) MDS_0892
( YP_004378675.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015410
(Pseudomonas mendocina NK-01)

2e-37

455) Aaci_2478
( YP_003185873.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013205
(Alicyclobacillus acidocaldarius DSM 446)

2e-37

456) H924_05010
( YP_007530351.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020506
(Corynebacterium callunae DSM 20147)

2e-37

457) nadC
( YP_006178897.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017668
(Halobacillus halophilus DSM 2266)

2e-37

458) BCO26_0445
( YP_004567890.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015634
(Bacillus coagulans 2-6)

3e-37

459) Cpha266_2293
( YP_912709.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008639
(Chlorobium phaeobacteroides DSM 266)

3e-37

460) HYPDE_28518
( YP_007913882.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021172
(Hyphomicrobium denitrificans 1NES1)

3e-37

461) Spiaf_2833
( YP_005476564.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017098
(Spirochaeta africana DSM 8902)

3e-37

462) Theam_1256
( YP_004151861.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014926
(Thermovibrio ammonificans HB-1)

3e-37

463) Ththe16_1003
( YP_005640546.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017272
(Thermus thermophilus SG0.5JP17-16)

3e-37

464) Desmer_0088
( YP_006620062.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018515
(Desulfosporosinus meridiei DSM 13257)

3e-37

465) Palpr_0188
( YP_004041335.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014734
(Paludibacter propionicigenes WB4)

3e-37

466) Bcer98_3144
( YP_001376362.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009674
(Bacillus cytotoxicus NVH 391-98)

4e-37

467) KKY_900
( YP_004898689.1 )

quinolinate phosphoribosyltransferase (decarboxylating)

NC_016078
(Pelagibacterium halotolerans B2)

4e-37

468) H681_04965
( YP_007656413.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020829
(Pseudomonas denitrificans ATCC 13867)

5e-37

469) L483_03950
( YP_008092619.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021491
(Pseudomonas putida H8234)

5e-37

470) Chro_5597
( YP_007094823.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019695
(Chroococcidiopsis thermalis PCC 7203)

6e-37

471) Spith_1063
( YP_006045052.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017583
(Spirochaeta thermophila DSM 6578)

7e-37

472) nadC
( YP_005851077.1 )

Nicotinate-nucleotide pyrophosphorylase, carboxylating

NC_017467
(Lactobacillus helveticus H10)

7e-37

473) R0052_11065
( YP_006656705.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018528
(Lactobacillus helveticus R0052)

7e-37

474) R0052_11115
( YP_006656715.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018528
(Lactobacillus helveticus R0052)

7e-37

475) Mlut_15690
( YP_002957615.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_012803
(Micrococcus luteus NCTC 2665)

7e-37

476) M5M_17925
( YP_006918443.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018868
(Simiduia agarivorans SA1)

7e-37

477) Hden_2000
( YP_003756122.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014313
(Hyphomicrobium denitrificans ATCC 51888)

8e-37

478) A11Q_1827
( YP_007645650.1 )

hypothetical protein

NC_020813
(Bdellovibrio exovorus JSS)

8e-37

479) nadC
( YP_478679.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007776
(Synechococcus sp. JA-2-3B'a(2-13))

9e-37

480) Clim_2139
( YP_001944142.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010803
(Chlorobium limicola DSM 245)

9e-37

481) nadC
( YP_004563578.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015602
(Lactobacillus kefiranofaciens ZW3)

9e-37

482) BDI_2086
( YP_001303439.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009615
(Parabacteroides distasonis ATCC 8503)

9e-37

483) Bpro_0902
( YP_547756.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007948
(Polaromonas sp. JS666)

9e-37

484) nadC
( YP_002728267.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_012438
(Sulfurihydrogenibium azorense Az-Fu1)

1e-36

485) SL003B_3339
( YP_004305065.1 )

quinolinate phosphoribosyltransferase

NC_015259
(Polymorphum gilvum SL003B-26A1)

1e-36

486) B2K_35905
( YP_006193795.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017672
(Paenibacillus mucilaginosus K02)

1e-36

487) STHERM_c10350
( YP_003874254.1 )

hypothetical protein

NC_014484
(Spirochaeta thermophila DSM 6192)

1e-36

488) nadC
( NP_901258.1 )

nicotinate-nucleotide pyrophosphorylase

NC_005085
(Chromobacterium violaceum ATCC 12472)

1e-36

489) XF1925
( NP_299211.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002488
(Xylella fastidiosa 9a5c)

1e-36

490) XFLM_10055
( YP_006001256.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017562
(Xylella fastidiosa GB514)

1e-36

491) Xfasm12_1043
( YP_001775636.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010513
(Xylella fastidiosa M12)

1e-36

492) XfasM23_0920
( YP_001829628.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010577
(Xylella fastidiosa M23)

1e-36

493) nadC
( NP_779085.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004556
(Xylella fastidiosa Temecula1)

1e-36

494) PM3016_7118
( YP_005316846.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016935
(Paenibacillus mucilaginosus 3016)

2e-36

495) KNP414_07574
( YP_004645935.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015690
(Paenibacillus mucilaginosus KNP414)

2e-36

496) C380_19015
( YP_006856135.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018708
(Acidovorax sp. KKS102)

2e-36

497) nadC
( YP_001629229.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010170
(Bordetella petrii DSM 12804)

2e-36

498) Tery_4352
( YP_723817.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008312
(Trichodesmium erythraeum IMS101)

2e-36

499) nadC
( YP_007594596.1 )

quinolinate phosphoribosyltransferase

NC_020547
(Acinetobacter baumannii D1279779)

2e-36

500) ABTJ_03769
( YP_006291612.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017847
(Acinetobacter baumannii MDR-TJ)

2e-36

501) Pmen_0778
( YP_001186278.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009439
(Pseudomonas mendocina ymp)

2e-36

502) nadC
( NP_980807.1 )

nicotinate-nucleotide pyrophosphorylase, carboxylating

NC_003909
(Bacillus cereus ATCC 10987)

2e-36

503) nadC
( YP_606645.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008027
(Pseudomonas entomophila L48)

2e-36

504) Psest_0718
( YP_007238941.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019936
(Pseudomonas stutzeri RCH2)

2e-36

505) nadC
( YP_007040978.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_019673
(Saccharothrix espanaensis DSM 44229)

2e-36

506) nadC
( YP_004327949.1 )

nicotinate-nucleotide diphosphorylase

NC_015311
(Prevotella denticola F0289)

3e-36

507) Desal_1976
( YP_002991575.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012881
(Desulfovibrio salexigens DSM 2638)

4e-36

508) Ssed_0427
( YP_001472168.1 )

nicotinate-nucleotide diphosphorylase

NC_009831
(Shewanella sediminis HAW-EB3)

4e-36

509) Taci_1755
( YP_003318251.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013522
(Thermanaerovibrio acidaminovorans DSM 6589)

4e-36

510) nadC
( YP_171301.1 )

nicotinate-nucleotide pyrophosphorylase

NC_006576
(Synechococcus elongatus PCC6301)

4e-36

511) PCC7424_1213
( YP_002376529.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011729
(Cyanothece sp. PCC 7424)

5e-36

512) BCK_13045
( YP_006596709.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018491
(Bacillus cereus FRI-35)

5e-36

513) nadC
( YP_003623683.1 )

Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase)

NC_014145
(Thiomonas sp. 3As)

5e-36

514) Oter_0786
( YP_001817674.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010571
(Opitutus terrae PB90-1)

6e-36

515) CE1115
( NP_737725.1 )

nicotinate-nucleotide pyrophosphorylase

NC_004369
(Corynebacterium efficiens YS-314)

6e-36

516) Mahau_1141
( YP_004463160.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015520
(Mahella australiensis 50-1 BON)

6e-36

517) Plim_0194
( YP_003628245.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014148
(Planctomyces limnophilus DSM 3776)

6e-36

518) B479_04410
( YP_007227741.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019905
(Pseudomonas putida PC9)

7e-36

519) PPS_0840
( YP_004700299.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015733
(Pseudomonas putida S16)

7e-36

520) nadC
( YP_007027724.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019670
(Pseudomonas sp. UW4)

8e-36

521) Cphamn1_2190
( YP_001960576.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010831
(Chlorobium phaeobacteroides BS1)

1e-35

522) Deba_0027
( YP_003806000.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014365
(Desulfarculus baarsii DSM 2075)

1e-35

523) Dhaf_0158
( YP_002456662.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011830
(Desulfitobacterium hafniense DCB-2)

1e-35

524) nadC
( YP_516447.1 )

nicotinate nucleotide pyrophosphorylase

NC_007907
(Desulfitobacterium hafniense Y51)

1e-35

525) nadC
( YP_008079093.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_021362
(Bacillus licheniformis 9945A)

1e-35

526) nadC
( YP_005940330.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017532
(Pseudomonas stutzeri DSM 4166)

1e-35

527) nadC
( YP_003423361.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_013790
(Methanobrevibacter ruminantium M1)

1e-35

528) Sulba_0257
( YP_006403159.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018002
(Sulfurospirillum barnesii SES-3)

1e-35

529) nadC
( YP_115488.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002977
(Methylococcus capsulatus Bath)

9e-36

530) nadC
( YP_002870460.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012660
(Pseudomonas fluorescens SBW25)

9e-36

531) nadC
( YP_004202395.1 )

nicotinate-nucleotide diphosphorylase

NC_014974
(Thermus scotoductus SA-01)

2e-35

532) ST1198
( NP_377130.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003106
(Sulfolobus tokodaii 7)

2e-35

533) Acife_1212
( YP_004783694.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015942
(Acidithiobacillus ferrivorans SS3)

2e-35

534) nadC
( YP_001174103.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009434
(Pseudomonas stutzeri A1501)

2e-35

535) nadC
( NP_662813.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002932
(Chlorobium tepidum TLS)

2e-35

536) amb3885
( YP_423248.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007626
(Magnetospirillum magneticum AMB-1)

2e-35

537) nadC
( YP_007369449.1 )

nicotinate-nucleotide pyrophosphatase NadC

NC_020133
(Mycobacterium liflandii 128FXT)

2e-35

538) nadC
( YP_006532739.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018220
(Pseudomonas putida DOT-T1E)

2e-35

539) nadC
( YP_004715973.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015740
(Pseudomonas stutzeri ATCC 17588)

2e-35

540) nadC
( YP_003427043.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013791
(Bacillus pseudofirmus OF4)

3e-35

541) nadC
( YP_001850698.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010612
(Mycobacterium marinum M)

3e-35

542) YSA_06639
( YP_006387464.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017986
(Pseudomonas putida ND6)

3e-35

543) Spea_0415
( YP_001500278.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009901
(Shewanella pealeana ATCC 700345)

3e-35

544) nadC
( YP_001240687.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009485
(Bradyrhizobium sp. BTAi1)

3e-35

545) Pput_0810
( YP_001266157.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009512
(Pseudomonas putida F1)

3e-35

546) nadC
( NP_742948.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002947
(Pseudomonas putida KT2440)

3e-35

547) Desac_2157
( YP_004371167.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015388
(Desulfobacca acetoxidans DSM 11109)

4e-35

548) Nos7107_2235
( YP_007050001.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019676
(Nostoc sp. PCC 7107)

4e-35

549) all2091
( NP_486131.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003272
(Nostoc sp. PCC 7120)

5e-35

550) Theco_3679
( YP_007214697.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019897
(Thermobacillus composti KWC4)

5e-35

551) Bcav_2774
( YP_002882781.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012669
(Beutenbergia cavernae DSM 12333)

5e-35

552) Daro_2380
( YP_285586.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_007298
(Dechloromonas aromatica RCB)

5e-35

553) Mic7113_2515
( YP_007121717.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019738
(Microcoleus sp. PCC 7113)

6e-35

554) Noca_0463
( YP_921692.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008699
(Nocardioides sp. JS614)

6e-35

555) Snov_0492
( YP_003692444.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014217
(Starkeya novella DSM 506)

6e-35

556) nadC
( YP_271452.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003910
(Colwellia psychrerythraea 34H)

6e-35

557) Ser39006_3855
( YP_008524237.1 )

nicotinate-nucleotide pyrophosphorylase

NC_022268
(Serratia sp. ATCC 39006)

6e-35

558) Sfum_0193
( YP_844330.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008554
(Syntrophobacter fumaroxidans MPOB)

1e-34

559) nadC
( YP_003207473.1 )

quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase)

NC_013260
(Candidatus Methylomirabilis oxyfera )

1e-34

560) nadC
( YP_005380347.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017034
(Methanocella conradii HZ254)

7e-35

561) nadC
( YP_002606624.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012115
(Nautilia profundicola AmH)

7e-35

562) nadC
( YP_905552.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008611
(Mycobacterium ulcerans Agy99)

7e-35

563) Nwat_2243
( YP_003761393.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014315
(Nitrosococcus watsonii C-113)

7e-35

564) nadC
( YP_003356175.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_013665
(Methanocella paludicola SANAE)

8e-35

565) Hipma_1555
( YP_004340570.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015318
(Hippea maritima DSM 10411)

8e-35

566) nadC
( YP_007326649.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020055
(Desulfovibrio hydrothermalis DSM 14728)

9e-35

567) Thivi_3094
( YP_006415099.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018012
(Thiocystis violascens DSM 198)

9e-35

568) Cyan7425_2495
( YP_002483213.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011884
(Cyanothece sp. PCC 7425)

1e-34

569) Ahos_2096
( YP_004459265.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015518
(Acidianus hospitalis W1)

2e-34

570) nadC
( YP_007492845.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_020409
(Desulfovibrio piezophilus C1TLV30)

2e-34

571) Mthe_0241
( YP_842678.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008553
(Methanosaeta thermophila PT)

2e-34

572) nadC
( NP_615908.1 )

nicotinate-nucleotide pyrophosphorylase

NC_003552
(Methanosarcina acetivorans C2A)

2e-34

573) Nther_2415
( YP_001918568.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010718
(Natranaerobius thermophilus JW/NM-WN-LF)

2e-34

574) Daes_1717
( YP_004121475.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014844
(Desulfovibrio aespoeensis Aspo-2)

2e-34

575) ECENHK_03935
( YP_006577298.1 )

quinolinate phosphoribosyltransferase

NC_018405
(Enterobacter cloacae ENHKU01)

2e-34

576) Theos_1009
( YP_006972159.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019386
(Thermus oshimai JL-2)

3e-34

577) nadC
( YP_006897650.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018828
(Bordetella parapertussis Bpp5)

3e-34

578) ABK1_0077
( YP_005512649.1 )

nadC

NC_017162
(Acinetobacter baumannii 1656-2)

3e-34

579) ACICU_00066
( YP_001844725.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010611
(Acinetobacter baumannii ACICU)

3e-34

580) BJAB0715_00084
( YP_008215232.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_021733
(Acinetobacter baumannii BJAB0715)

3e-34

581) BJAB0868_00083
( YP_008211410.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_021729
(Acinetobacter baumannii BJAB0868)

3e-34

582) ABZJ_00069
( YP_005524025.1 )

nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

NC_017171
(Acinetobacter baumannii MDR-ZJ06)

3e-34

583) nadC
( YP_001705809.1 )

nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

NC_010400
(Acinetobacter baumannii SDF)

3e-34

584) ABTW07_0074
( YP_005796963.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017387
(Acinetobacter baumannii TCDC-AB0715)

3e-34

585) nadC
( NP_885994.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002928
(Bordetella parapertussis 12822)

3e-34

586) Cpar_0276
( YP_001997903.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011027
(Chlorobaculum parvum NCIB 8327)

3e-34

587) W5S_3900
( YP_006284835.1 )

Quinolinate phosphoribosyltransferase

NC_017845
(Pectobacterium sp. SCC3193)

3e-34

588) Aave_3851
( YP_972170.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008752
(Acidovorax citrulli AAC00-1)

4e-34

589) nadC
( YP_002317500.1 )

nicotinate-nucleotide diphosphorylase

NC_011586
(Acinetobacter baumannii AB0057)

4e-34

590) nadC
( YP_002327338.1 )

nicotinate-nucleotide diphosphorylase (carboxylating)

NC_011595
(Acinetobacter baumannii AB307-0294)

4e-34

591) nadC
( YP_001715540.1 )

nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

NC_010410
(Acinetobacter baumannii AYE)

4e-34

592) M3Q_276
( YP_006846603.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018706
(Acinetobacter baumannii TYTH-1)

4e-34

593) FIC_02362
( YP_003096857.1 )

Quinolinate phosphoribosyltransferase (decarboxylating)

NC_013062
(Flavobacteriaceae bacterium 3519-10)

4e-34

594) nadC
( YP_006970165.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019382
(Bordetella bronchiseptica 253)

5e-34

595) nadC
( YP_006902192.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018829
(Bordetella bronchiseptica MO149)

5e-34

596) nadC
( NP_890821.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002927
(Bordetella bronchiseptica RB50)

5e-34

597) nadC
( YP_006624993.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018518
(Bordetella pertussis 18323)

5e-34

598) nadC
( YP_005591620.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017223
(Bordetella pertussis CS)

5e-34

599) nadC
( NP_882228.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002929
(Bordetella pertussis Tohama I)

5e-34

600) BJAB07104_00082
( YP_008207548.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_021726
(Acinetobacter baumannii BJAB07104)

5e-34

601) nadC
( YP_003775624.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014323
(Herbaspirillum seropedicae SmR1)

5e-34

602) Acav_3759
( YP_004236217.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015138
(Acidovorax avenae ATCC 19860)

7e-34

603) nadC
( YP_001140342.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009348
(Aeromonas salmonicida A449)

8e-34

604) Hhal_2042
( YP_001003608.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008789
(Halorhodospira halophila SL1)

8e-34

605) PYCH_12720
( YP_004624216.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015680
(Pyrococcus yayanosii CH1)

8e-34

606) F7308_1483
( YP_004648008.1 )

Quinolinate phosphoribosyltransferase

NC_015696
(Francisella sp. TX077308)

9e-34

607) Strvi_8877
( YP_004818458.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015957
(Streptomyces violaceusniger Tu 4113)

9e-34

608) mll6272
( NP_106807.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002678
(Mesorhizobium loti MAFF303099)

1e-33

609) Namu_3164
( YP_003202486.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013235
(Nakamurella multipartita DSM 44233)

2e-33

610) nadC
( YP_004997231.1 )

nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

NC_016603
(Acinetobacter calcoaceticus PHEA-2)

2e-33

611) ENC_46200
( YP_007847787.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_021046
(Enterobacter cloacae NCTC 9394)

2e-33

612) PCC21_035680
( YP_006648224.1 )

quinolinate phosphoribosyltransferase

NC_018525
(Pectobacterium carotovorum PCC21)

2e-33

613) A1S_0044
( YP_001083141.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009085
(Acinetobacter baumannii ATCC 17978)

2e-33

614) ECL_00905
( YP_003611417.1 )

quinolinate phosphoribosyltransferase

NC_014121
(Enterobacter cloacae ATCC 13047)

2e-33

615) nadC
( YP_004950582.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016514
(Enterobacter cloacae EcWSU1)

2e-33

616) Dfer_3879
( YP_003088248.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013037
(Dyadobacter fermentans DSM 18053)

3e-33

617) A3UG_03760
( YP_006476201.1 )

quinolinate phosphoribosyltransferase

NC_018079
(Enterobacter cloacae SDM)

3e-33

618) nadC
( YP_007404591.1 )

quinolinate phosphoribosyltransferase

NC_020211
(Serratia marcescens WW4)

3e-33

619) HydHO_1045
( YP_007500403.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_020411
(Hydrogenobaculum sp. HO)

4e-33

620) HydSN_1072
( YP_007647462.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_020814
(Hydrogenobaculum sp. SN)

4e-33

621) nadC
( YP_003555008.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014012
(Shewanella violacea DSS12)

4e-33

622) Swoo_0315
( YP_001758711.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010506
(Shewanella woodyi ATCC 51908)

4e-33

623) Fphi_1848
( YP_001678577.1 )

nicotinate-nucleotide diphosphorylase

NC_010336
(Francisella philomiragia ATCC 25017)

4e-33

624) Varpa_4765
( YP_004157037.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014931
(Variovorax paradoxus EPS)

5e-33

625) Psefu_0599
( YP_004472673.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015556
(Pseudomonas fulva 12-X)

5e-33

626) Tint_0897
( YP_003642621.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014153
(Thiomonas intermedia K12)

5e-33

627) Ava_3136
( YP_323639.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007413
(Anabaena variabilis ATCC 29413)

6e-33

628) nadC
( YP_685028.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009464
(Methanocella arvoryzae MRE50)

6e-33

629) Glo7428_4347
( YP_007129950.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_019745
(Gloeocapsa sp. PCC 7428)

7e-33

630) Shew_3435
( YP_001095560.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009092
(Shewanella loihica PV-4)

7e-33

631) Ppha_2566
( YP_002019345.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011060
(Pelodictyon phaeoclathratiforme BU-1)

7e-33

632) nadC
( NP_070665.1 )

nicotinate-nucleotide pyrophosphorylase

NC_000917
(Archaeoglobus fulgidus DSM 4304)

1e-32

633) Metme_4340
( YP_004515188.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015572
(Methylomonas methanica MC09)

1e-32

634) CL1_0797
( YP_006424796.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018015
(Thermococcus sp. CL1)

1e-32

635) nadC
( YP_858306.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008570
(Aeromonas hydrophila ATCC 7966)

2e-32

636) nadC
( YP_003432302.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013799
(Hydrogenobacter thermophilus TK-6)

2e-32

637) Hydth_0638
( YP_005511329.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017161
(Hydrogenobacter thermophilus TK-6)

2e-32

638) MM_2070
( NP_634094.1 )

nicotinate-nucleotide pyrophosphate carboxylating protein

NC_003901
(Methanosarcina mazei Go1)

2e-32

639) MmTuc01_2137
( YP_007490737.1 )

Quinolinate phosphoribosyltransferase

NC_020389
(Methanosarcina mazei Tuc01)

2e-32

640) ABLL_2558
( YP_005554750.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017192
(Arcobacter sp. L)

3e-32

641) AOLE_19175
( YP_003734090.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014259
(Acinetobacter oleivorans DR1)

4e-32

642) nadC
( YP_006557814.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018268
(Marinobacter sp. BSs20148)

4e-32

643) nadC
( YP_007892224.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021149
(Azotobacter vinelandii CA)

5e-32

644) nadC
( YP_007897272.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021150
(Azotobacter vinelandii CA6)

5e-32

645) nadC
( YP_002798413.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012560
(Azotobacter vinelandii DJ)

5e-32

646) DND132_0380
( YP_005166401.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016803
(Desulfovibrio desulfuricans ND132)

6e-32

647) Emtol_1417
( YP_006872590.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018748
(Emticicia oligotrophica DSM 17448)

6e-32

648) NH44784_014371
( YP_008028532.1 )

Quinolinate phosphoribosyltransferase [decarboxylating]

NC_021285
(Achromobacter xylosoxidans NH44784-1996)

1e-31

649) nadC
( YP_003519031.1 )

NadC

NC_013956
(Pantoea ananatis LMG 20103)

1e-31

650) nadC
( YP_007001321.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_004347
(Shewanella oneidensis MR-1)

7e-32

651) B932_2816
( YP_006985292.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019396
(Gluconobacter oxydans H24)

8e-32

652) D782_3763
( YP_007341856.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_020063
(Enterobacteriaceae bacterium FGI 57)

9e-32

653) nadC
( YP_005932960.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC

NC_017531
(Pantoea ananatis AJ13355)

9e-32

654) nadC
( YP_005197005.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_016816
(Pantoea ananatis LMG 5342)

9e-32

655) Sput200_3559
( YP_006011411.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017566
(Shewanella putrefaciens 200)

9e-32

656) Sputcn32_3421
( YP_001184930.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009438
(Shewanella putrefaciens CN-32)

9e-32

657) Sputw3181_0522
( YP_961927.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008750
(Shewanella sp. W3-18-1)

9e-32

658) Fraau_2238
( YP_005378296.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017033
(Frateuria aurantia DSM 6220)

1e-31

659) nadC
( YP_001121657.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009257
(Francisella tularensis WY96-3418)

1e-31

660) S58_32030
( YP_007512788.1 )

quinolinate phosphoribosyltransferase

NC_020453
(Bradyrhizobium oligotrophicum S58)

2e-31

661) Mmah_1982
( YP_003543122.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_014002
(Methanohalophilus mahii DSM 5219)

2e-31

662) Deima_2834
( YP_004172128.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014958
(Deinococcus maricopensis DSM 21211)

2e-31

663) HY04AAS1_1050
( YP_002121714.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011126
(Hydrogenobaculum sp. Y04AAS1)

2e-31

664) Fbal_0365
( YP_003911653.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_014541
(Ferrimonas balearica DSM 9799)

2e-31

665) Psed_2847
( YP_004332900.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015312
(Pseudonocardia dioxanivorans CB1190)

3e-31

666) AnaeK_1475
( YP_002133835.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011145
(Anaeromyxobacter sp. K)

3e-31

667) PputGB1_0821
( YP_001667067.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010322
(Pseudomonas putida GB-1)

3e-31

668) PAGR_g3462
( YP_005994174.1 )

nicotinate-nucleotide pyrophosphorylase NadC

NC_017554
(Pantoea ananatis PA13)

3e-31

669) Pat9b_0681
( YP_004114562.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014837
(Pantoea sp. At-9b)

3e-31

670) DvMF_0524
( YP_002434949.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011769
(Desulfovibrio vulgaris Miyazaki F)

4e-31

671) AHML_20490
( YP_008045204.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021290
(Aeromonas hydrophila ML09-119)

5e-31

672) Hneap_2251
( YP_003264113.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013422
(Halothiobacillus neapolitanus c2)

6e-31

673) PSEBR_a784
( YP_004351952.1 )

nicotinate-nucleotide diphosphorylase

NC_015379
(Pseudomonas brassicacearum NFM421)

9e-31

674) SCE1572_15415
( YP_008149513.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021658
(Sorangium cellulosum So0157-2)

1e-30

675) B565_0360
( YP_004391012.1 )

Quinolinate phosphoribosyltransferase

NC_015424
(Aeromonas veronii B565)

1e-30

676) FN3523_0644
( YP_005823698.1 )

quinolinate phosphoribosyltransferase

NC_017449
(Francisella novicida 3523)

1e-30

677) Metho_0367
( YP_007312170.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019977
(Methanomethylovorans hollandica DSM 15978)

2e-30

678) FNFX1_0700
( YP_005825608.1 )

hypothetical protein

NC_017450
(Francisella novicida Fx1)

2e-30

679) nadC
( YP_005784326.1 )

Nicotinate nucleotide phosphorylase

NC_017374
(Helicobacter pylori 2017)

2e-30

680) nadC
( YP_005792174.1 )

Nicotinate-nucleotide pyrophosphorylase/Quinolinate phosphoribosyltransferase

NC_017381
(Helicobacter pylori 2018)

2e-30

681) Halxa_1866
( YP_004596373.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015666
(Halopiger xanaduensis SH-6)

2e-30

682) Mvan_2800
( YP_953613.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008726
(Mycobacterium vanbaalenii PYR-1)

3e-30

683) hp908_1359
( YP_005765854.1 )

quinolinate phosphoribosyl transferase

NC_017357
(Helicobacter pylori 908)

3e-30

684) LD85_1338
( YP_003419376.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013769
(Sulfolobus islandicus L.D.8.5)

4e-30

685) nadC
( YP_008472595.1 )

nicotinate-nucleotide diphosphorylase

NC_022130
(Helicobacter pylori SouthAfrica20)

5e-30

686) Srot_0710
( YP_003658023.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014168
(Segniliparus rotundus DSM 44985)

6e-30

687) nadC
( YP_003058005.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012973
(Helicobacter pylori B38)

6e-30

688) nadC
( NP_223991.1 )

nicotinate-nucleotide pyrophosphorylase

NC_000921
(Helicobacter pylori J99)

6e-30

689) SiH_1175
( YP_005645738.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017275
(Sulfolobus islandicus HVE10/4)

6e-30

690) LS215_1316
( YP_002831969.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012589
(Sulfolobus islandicus L.S.2.15)

6e-30

691) M1425_1224
( YP_002829280.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012588
(Sulfolobus islandicus M.14.25)

6e-30

692) M164_1208
( YP_002914482.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012726
(Sulfolobus islandicus M.16.4)

6e-30

693) SiRe_1091
( YP_005648372.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017276
(Sulfolobus islandicus REY15A)

6e-30

694) YG5714_1213
( YP_002837403.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012622
(Sulfolobus islandicus Y.G.57.14)

6e-30

695) YN1551_1634
( YP_002840642.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012623
(Sulfolobus islandicus Y.N.15.51)

6e-30

696) HPIN_07120
( YP_005782700.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017372
(Helicobacter pylori India7)

7e-30

697) HPGAM_07015
( YP_005781065.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017371
(Helicobacter pylori Gambia94/24)

7e-30

698) GU3_15365
( YP_005093576.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016745
(Oceanimonas sp. GK1)

7e-30

699) nadC
( YP_006371326.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017956
(Tistrella mobilis KA081020-065)

7e-30

700) Exig_2100
( YP_001814569.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010556
(Exiguobacterium sibiricum 255-15)

8e-30

701) HPSNT_06785
( YP_005787467.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017376
(Helicobacter pylori Santal49)

8e-30

702) Thimo_1735
( YP_007244139.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019940
(Thioflavicoccus mobilis 8321)

9e-30

703) nadC
( YP_001206486.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009445
(Bradyrhizobium sp. ORS278)

1e-29

704) HPLT_06800
( YP_005773465.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017362
(Helicobacter pylori Lithuania75)

1e-29

705) nadC
( YP_007536157.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020508
(Helicobacter pylori OK113)

1e-29

706) HPPC18_06775
( YP_006229576.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017742
(Helicobacter pylori PeCan18)

1e-29

707) K750_01635
( YP_007981687.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021217
(Helicobacter pylori UM037)

1e-29

708) Mspyr1_29600
( YP_004077414.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014814
(Mycobacterium gilvum Spyr1)

2e-29

709) SiL_1089
( YP_007865544.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021058
(Sulfolobus islandicus LAL14/1)

8e-30

710) Deipe_2574
( YP_007181805.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019793
(Deinococcus peraridilitoris DSM 19664)

2e-29

711) nadC
( YP_002301983.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011498
(Helicobacter pylori P12)

2e-29

712) nadC
( YP_002225287.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011274
(Salmonella enterica 287/91)

2e-29

713) STMMW_01511
( YP_005231231.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016854
(Salmonella enterica D23580)

2e-29

714) nadC
( YP_002242311.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011294
(Salmonella enterica P125109)

2e-29

715) nadC
( YP_005180082.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016810
(Salmonella enterica SL1344)

2e-29

716) Dde_1831
( YP_388323.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007519
(Desulfovibrio alaskensis G20)

2e-29

717) HPSJM_06800
( YP_003929237.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014560
(Helicobacter pylori SJM180)

2e-29

718) Mflv_3617
( YP_001134879.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009338
(Mycobacterium gilvum PYR-GCK)

2e-29

719) OCC_06601
( YP_008428953.1 )

nicotinate-nucleotide pyrophosphorylase

NC_022084
(Thermococcus litoralis DSM 5473)

2e-29

720) M446_4589
( YP_001771363.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010511
(Methylobacterium sp. 4-46)

3e-29

721) nadC
( YP_664050.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008229
(Helicobacter acinonychis Sheeba)

3e-29

722) nadC
( NP_280601.1 )

hypothetical protein

NC_002607
(Halobacterium salinarum NRC-1)

3e-29

723) nadC
( YP_001689720.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_010364
(Halobacterium salinarum R1)

3e-29

724) HPB14_06485
( YP_006219993.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017733
(Helicobacter pylori HUP-B14)

4e-29

725) HPPC_06665
( YP_003927591.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014555
(Helicobacter pylori PeCan4)

4e-29

726) Oweho_1383
( YP_004989025.1 )

nicotinate-nucleotide pyrophosphorylase

NC_016599
(Owenweeksia hongkongensis DSM 17368)

4e-29

727) F504_2408
( YP_007633421.1 )

Quinolinate phosphoribosyltransferase [decarboxylating]

NC_020799
(Ralstonia solanacearum FQY_4)

5e-29

728) Mjls_3083
( YP_001071353.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009077
(Mycobacterium sp. JLS)

5e-29

729) Ssol_1973
( YP_005643785.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017274
(Sulfolobus solfataricus 98/2)

5e-29

730) SSO0996
( NP_342477.1 )

nicotinate-nucleotide pyrophosphorylase

NC_002754
(Sulfolobus solfataricus P2)

5e-29

731) Mkms_3126
( YP_939110.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008705
(Mycobacterium sp. KMS)

6e-29

732) Mmcs_3066
( YP_640229.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008146
(Mycobacterium sp. MCS)

6e-29

733) HP1355
( NP_208147.1 )

nicotinate-nucleotide pyrophosphorylase

NC_000915
(Helicobacter pylori 26695)

6e-29

734) C694_06995
( YP_006935277.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018939
(Helicobacter pylori 26695)

6e-29

735) C695_07005
( YP_006893843.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018937
(Helicobacter pylori Rif1)

6e-29

736) C730_07005
( YP_006936884.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018938
(Helicobacter pylori Rif2)

6e-29

737) HPELS_07030
( YP_005425502.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017063
(Helicobacter pylori ELS37)

6e-29

738) HPG27_1303
( YP_002266917.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011333
(Helicobacter pylori G27)

6e-29

739) HPSA_07780
( YP_005772108.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017361
(Helicobacter pylori SouthAfrica7)

8e-29

740) Hbor_10050
( YP_004036044.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014729
(Halogeometricum borinquense DSM 11551)

1e-28

741) Adeh_2389
( YP_465596.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007760
(Anaeromyxobacter dehalogenans 2CP-C)

2e-28

742) MTH1832
( NP_276938.1 )

quinolinate phosphoribosyltransferase

NC_000916
(Methanothermobacter thermautotrophicus Delta H)

2e-28

743) nadC
( YP_005778279.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017368
(Helicobacter pylori F16)

2e-28

744) K751_07525
( YP_007984444.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021218
(Helicobacter pylori UM066)

2e-28

745) nadC
( YP_006922856.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_018876
(Methanolobus psychrophilus R15)

2e-28

746) nadC
( YP_006337749.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017926
(Helicobacter pylori XZ274)

2e-28

747) nadC
( YP_002786050.1 )

nicotinate-nucleotide diphosphorylase

NC_012526
(Deinococcus deserti VCD115)

3e-28

748) nadC
( YP_005784618.1 )

nicotinate-nucleotide diphosphorylase

NC_017375
(Helicobacter pylori 83)

3e-28

749) HCD_04220
( YP_006221068.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017735
(Helicobacter cetorum MIT 99-5656)

3e-28

750) Natpe_3454
( YP_007282133.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019962
(Natrinema pellirubrum DSM 15624)

3e-28

751) Svir_10850
( YP_003132968.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_013159
(Saccharomonospora viridis DSM 43017)

4e-28

752) HPSH169_06740
( YP_006226502.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017740
(Helicobacter pylori Shi169)

6e-28

753) HPSH417_06660
( YP_006224946.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017739
(Helicobacter pylori Shi417)

6e-28

754) nadC
( YP_003929809.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_014562
(Pantoea vagans C9-1)

7e-28

755) HPCU_06920
( YP_005767434.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017358
(Helicobacter pylori Cuz20)

7e-28

756) HPSH112_06795
( YP_006228039.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017741
(Helicobacter pylori Shi112)

7e-28

757) nadC
( YP_005769414.1 )

nicotinate-nucleotide diphosphorylase

NC_017360
(Helicobacter pylori 35A)

8e-28

758) M1627_1279
( YP_002843208.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012632
(Sulfolobus islandicus M.16.27)

9e-28

759) HCW_00960
( YP_006222115.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017737
(Helicobacter cetorum MIT 00-7128)

9e-28

760) Afer_0958
( YP_003109570.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013124
(Acidimicrobium ferrooxidans DSM 10331)

1e-27

761) nadC
( YP_005467509.1 )

putative quinolinate phosphoribosyltransferase

NC_017093
(Actinoplanes missouriensis 431)

1e-27

762) Syncc9605_2452
( YP_382739.1 )

nicotinate-nucleotide pyrophosphorylase [carboxylating]

NC_007516
(Synechococcus sp. CC9605)

2e-27

763) nadC
( YP_005776760.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017367
(Helicobacter pylori F57)

2e-27

764) nadC
( YP_585015.1 )

nicotinate-nucleotide pyrophosphorylase

NC_007973
(Cupriavidus metallidurans CH34)

2e-27

765) K747_08775
( YP_007978781.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021215
(Helicobacter pylori UM032)

2e-27

766) K748_04005
( YP_008336699.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021882
(Helicobacter pylori UM298)

2e-27

767) K749_05600
( YP_007980886.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021216
(Helicobacter pylori UM299)

2e-27

768) nadC
( YP_005792458.1 )

quinolinate phosphoribosyl transferase

NC_017382
(Helicobacter pylori 51)

2e-27

769) nadC
( YP_005773791.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017365
(Helicobacter pylori F30)

2e-27

770) nadC
( YP_005775271.1 )

nicotinate-nucleotide pyrophosphorylase

NC_017366
(Helicobacter pylori F32)

2e-27

771) nadC
( YP_007537678.1 )

nicotinate-nucleotide pyrophosphorylase

NC_020509
(Helicobacter pylori OK310)

2e-27

772) Intca_0615
( YP_004097887.1 )

nicotinate-nucleotide pyrophosphorylase

NC_014830
(Intrasporangium calvum DSM 43043)

2e-27

773) nadC
( YP_007955846.1 )

nicotinate-nucleotide pyrophosphorylase

NC_021191
(Actinoplanes sp. N902-109)

3e-27

774) H729_08315
( YP_008072426.1 )

Quinolinate phosphoribosyltransferase (decarboxylating)

NC_021353
(Methanomassiliicoccus sp. Mx1-Issoire)

5e-27

775) R2APBS1_2937
( YP_007591247.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_020541
(Rhodanobacter sp. 2APBS1)

7e-27

776) Rhom172_0200
( YP_004823985.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015966
(Rhodothermus marinus SG0.5JP17-172)

2e-26

777) A2cp1_1570
( YP_002491980.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011891
(Anaeromyxobacter dehalogenans 2CP-1)

2e-26

778) nadC
( YP_005206302.1 )

protein NadC

NC_016830
(Pseudomonas fluorescens F113)

4e-26

779) Rmar_0217
( YP_003289511.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013501
(Rhodothermus marinus DSM 4252)

4e-26

780) nadC
( YP_006364696.1 )

quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase)

NC_017955
(Modestobacter marinus BC501)

7e-26

781) nadC
( YP_004007401.1 )

nicotinate-nucleotide diphosphorylase (carboxylating) nadc

NC_014659
(Rhodococcus equi 103S)

1e-25

782) Htur_0528
( YP_003402099.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013743
(Haloterrigena turkmenica DSM 5511)

3e-25

783) Smal_1368
( YP_002027756.1 )

nicotinate-nucleotide pyrophosphorylase

NC_011071
(Stenotrophomonas maltophilia R551-3)

3e-25

784) nadC
( YP_006184175.1 )

quinolinate phosphoribosyltransferase

NC_017671
(Stenotrophomonas maltophilia D457)

4e-24

785) nadC
( YP_004892048.1 )

Nicotinate-nucleotide pyrophosphorylase

NC_016070
(Thermoproteus tenax Kra 1)

4e-24

786) nadC
( YP_006567878.1 )

nicotinate-nucleotide pyrophosphorylase carboxylating

NC_018289
(Mycobacterium smegmatis MC2 155)

5e-24

787) nadC
( YP_887515.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008596
(Mycobacterium smegmatis MC2 155)

5e-24

788) nadC
( YP_701021.1 )

nicotinate-nucleotide pyrophosphorylase

NC_008268
(Rhodococcus jostii RHA1)

5e-24

789) MFS40622_1764
( YP_003459171.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013887
(Methanocaldococcus sp. FS406-22)

1e-23

790) nadC
( YP_002777953.1 )

nicotinate-nucleotide pyrophosphorylase

NC_012522
(Rhodococcus opacus B4)

2e-23

791) BurJV3_1358
( YP_004791916.1 )

nicotinate-nucleotide pyrophosphorylase

NC_015947
(Stenotrophomonas maltophilia JV3)

2e-23

792) Cwoe_4594
( YP_003396382.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013739
(Conexibacter woesei DSM 14684)

3e-23

793) Hmuk_1495
( YP_003177317.1 )

nicotinate-nucleotide pyrophosphorylase

NC_013202
(Halomicrobium mukohataei DSM 12286)

3e-23

794) Metfor_2688
( YP_007250183.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019943
(Methanoregula formicicum SMSP)

3e-23

795) A35E_00349
( YP_006589075.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_018420
(secondary endosymbiont of Heteropsylla cubana )

4e-23

796) O3I_012210
( YP_006807377.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018681
(Nocardia brasiliensis HUJEG-1)

1e-22

797) nadC
( YP_001971447.1 )

nicotinate-nucleotide pyrophosphorylase

NC_010943
(Stenotrophomonas maltophilia K279a)

9e-23

798) Halru_1261
( YP_007284008.1 )

nicotinate-nucleotide pyrophosphorylase

NC_019964
(Halovivax ruber XH-70)

7e-22

799) nadC
( YP_004523404.1 )

nicotinate-nucleotide pyrophosphatase NadC

NC_015576
(Mycobacterium sp. JDM601)

3e-21

800) Mevan_0043
( YP_001322570.1 )

nicotinate-nucleotide pyrophosphorylase

NC_009634
(Methanococcus vannielii SB)

8e-21

801) NJ7G_0686
( YP_006540019.1 )

nicotinate-nucleotide pyrophosphorylase

NC_018224
(Natrinema sp. J7-2)

1e-20

802) nadC
( YP_003536595.1 )

nicotinate-nucleotide pyrophosphorylase (carboxylating)

NC_013967
(Haloferax volcanii DS2)

3e-19

• Sequence Alignments

1) nadC in NC_018936


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

2) SPYALAB49_000206 in NC_017596


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

3) SPYALAB49_001084 in NC_017596


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

4) nadC in NC_020540


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

5) nadC in NC_009332


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

6) M6_Spy1061 in NC_006086


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

7) nadC in NC_008024


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

8) nadC in NC_007297


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

9) spyM18_1346 in NC_003485


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1643),  Expect = 6e-124, Method: Compositional matrix adjust.
 Identities = 290/290 (100%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

10) nadC in NC_002737


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1642),  Expect = 8e-124, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDTEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFD+EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

11) nadC in NC_008023


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1642),  Expect = 8e-124, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYISSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDY+SSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

12) nadC in NC_007296


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1642),  Expect = 8e-124, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLASGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRL+SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

13) nadC in NC_008021


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  436 bits (1642),  Expect = 8e-124, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYISSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDY+SSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

14) L897_05425 in NC_021807


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  435 bits (1640),  Expect = 1e-123, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 289/290 (99%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIDQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAI QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

15) nadC in NC_008022


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  435 bits (1639),  Expect = 1e-123, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHSQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHH+QAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARTYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQAR+YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

16) nadC in NC_004070


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  435 bits (1638),  Expect = 2e-123, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFMKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPF+KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

17) Spy49_0176 in NC_011375


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  435 bits (1638),  Expect = 2e-123, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 289/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDXEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFD EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

18) SPs0845 in NC_004606


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  435 bits (1638),  Expect = 2e-123, Method: Compositional matrix adjust.
 Identities = 289/290 (99%), Positives = 290/290 (100%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFMKMveveveslaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPF+KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

19) nadC in NC_017040


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  433 bits (1631),  Expect = 6e-123, Method: Compositional matrix adjust.
 Identities = 286/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSTISTDLIPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MS ISTDL PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLASGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRL+SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMvevevetlaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVE+LAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

20) nadC in NC_017053


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  433 bits (1631),  Expect = 6e-123, Method: Compositional matrix adjust.
 Identities = 286/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSTISTDLIPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MS ISTDL PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLASGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRL+SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMvevevetlaaaeeaaaaGVDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVE+LAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

21) nadC in NC_012468


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

22) SPAP_2044 in NC_014494


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

23) nadC in NC_008533


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

24) nadC in NC_011072


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

25) nadC in NC_010380


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

26) nadC in NC_012466


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

27) nadC in NC_003098


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1612),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

28) nadC in NC_018594


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

29) MYY_1937 in NC_017769


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

30) nadC in NC_012469


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1611),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

31) nadC in NC_014251


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  428 bits (1612),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 288/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  189
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

32) nadC in NC_010582


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  427 bits (1606),  Expect = 5e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  189
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

33) HMPREF1038_02012 in NC_018630


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  427 bits (1606),  Expect = 5e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  10   MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  69
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  70   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  129
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  130  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  189
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  190  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  249
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  250  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  299
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

34) nadC in NC_014498


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1602),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 287/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  TTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
             TAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

35) nadC in NC_021006


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1602),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 286/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQRAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQ+AIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

36) nadC in NC_011900


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1605),  Expect = 6e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

37) nadC in NC_017591


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1605),  Expect = 6e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

38) nadC in NC_017593


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1605),  Expect = 6e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

39) nadC in NC_012467


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1605),  Expect = 6e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

40) SP_2016 in NC_003028


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  426 bits (1605),  Expect = 6e-121, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 288/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI+LKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

41) nadC in NC_017592


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  425 bits (1601),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 287/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVLLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV LFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

42) nadC in NC_021028


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  425 bits (1601),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 287/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVLLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV LFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

43) nadC in NC_021026


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  425 bits (1601),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 287/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVLLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV LFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

44) nadC in NC_021005


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  425 bits (1601),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 287/290 (99%), Positives = 287/290 (99%), Gaps = 0/290 (0%)

Query  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVLLFAKEAGVLAGLTVF  60
            MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV LFAKEAGVLAGLTVF
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120
            QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  121  MTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180
            MTAAYVEALGDD IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  181  GSVQKAIAQARAYAPFVKMveveveslaaaeeaaaagaDIIMLDNMSLEQIEQAITLIAG  240
            GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG DIIMLDNMSLEQIEQAITLIAG
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290
            RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV  290

45) HMPREF0409_01960 in NC_021281


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  264 bits (988),  Expect = 3e-72, Method: Compositional matrix adjust.
 Identities = 167/283 (60%), Positives = 223/283 (79%), Gaps = 4/283 (1%)

Query  6    IDKFQMDDSIRMALKEDITSEDISTNAIYKNDRLAEISLYSKEDGILAGLDVFKRVFELL  65
            +  FQ+DD+++ AL+ED+ SED STNAI+ ++  A +SL++KE G+LAGL VF+RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  66   DNSVEFT---EYKKDGDKVLNKDLILKIRADVKTILSAERTALNYLQRMSGIATYTRKMV  122
            D  V F    ++K DGD++ + DL+L I + V+++L+ ER ALN+LQ++SGIA+ T   V
Sbjct  68   DAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  123  EALDDKNILLLDTRKTTPNMRIFEKYAVRVGGGYNHRYNLSDAIMLKDNHINAAGSITEA  182
            EAL+D  I ++DTRKTTPN+R+FEKYAVRVGGGYNHR+NLSDAIMLKDNHI A GS+  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  183  IKLAKEYSPFIKKIEVEVEDLKGVEEAVAAGADIIMLDNMDIEttkkaikiinkktiiEC  242
            I  A+ Y+PF+K +EVEVE L + EEA AAG DIIMLDNM +E   +AI +I  ++ IEC
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  243  SGNIDITNINRFKGLEIDYVSSGAITHSAKILDLSLKNLRYID  285
            SGNID+T I+RF+GL IDYVSSG++THSAK LD+S+K L Y+D
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

46) nadC in NC_015975


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  249 bits (930),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 145/277 (53%), Positives = 212/277 (77%), Gaps = 4/277 (1%)

Query  7    TLQADHLILEALKEDISSEDVTTNSVMKDYVKGEVELICKQDGVIAGLEVYRRVFELLDA  66
             +Q D+ +  AL+ED+ SED +TN++  +  ++ V L+ K+ GV+AGL V++RVF L+DA
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  67   DT---KTELYCKDGDEVKNGQLMGKVTGDIRVLLSGERVALNYLQRMSGIATYTHSVAGL  123
            +    + + + KDGD + +G+L+  + G +R LL+ ERVALN+LQ++SGIA+ T +    
Sbjct  70   EVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  124  LEGSKTKLLDTRKTTPNMRIFEKYAVRVGGGYNHRYNLSDGVLLKDNHIGAAGGVRKAVE  183
            L + + K++DTRKTTPN+R+FEKYAVRVGGGYNHR+NLSD+++LKDNHI+A G+V+KA+ 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  184  MAKDYAPFVRKIEVEVENLEMVKEAVEAGADIIMLDNMSTEEMQEAIKIIDGRAEVECSG  243
             A+ YAPFV+ +EVEVE+L    EA  AG DIIMLDNMS E++++AI +I GR+ +ECSG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  244  NVTKENIGRLTALGVDYISSGALTHSAPILDISMKNL  280
            N+    I+R+ +L++DY+SSG+LTHSA  LD+SMK L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

47) RTO_13590 in NC_021015


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  248 bits (926),  Expect = 3e-67, Method: Compositional matrix adjust.
 Identities = 145/277 (53%), Positives = 211/277 (77%), Gaps = 4/277 (1%)

Query  7    TLQADHLILEALKEDISSEDVTTNSVMKDYVKGEVELICKQDGIIAGLEVYRRVFELLDA  66
             +Q D+ +  AL+ED+ SED +TN++  +  ++ V L+ K+ G++AGL V++RVF L+DA
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  67   DT---KTELYCKDGDEVKNGQLMGKVTGDIRVLLSGERVALNYLQRMSGIATYTHSVAGL  123
            +    + + + KDGD + +G+L+  + G +R LL+ ERVALN+LQ++SGIA+ T +    
Sbjct  70   EVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  124  LEGSKTKLLDTRKTTPNMRIFEKYAVRVGGGYNHRYNLSDGVLLKDNHIGAAGSVKKAVE  183
            L + + K++DTRKTTPN+R+FEKYAVRVGGGYNHR+NLSD+++LKDNHI+A GSV+KA+ 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  184  MAKDYAPFVRKIEVEVENLEMVKEAVEAGADIIMLDNMSTEEMQEAIKIIDGRAETECSG  243
             A+ YAPFV+ +EVEVE+L    EA  AG DIIMLDNMS E++++AI +I GR+  ECSG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  244  NVTKENIGRLTALGVDYISSGALTHSAPILDISMKNL  280
            N+    I+R+ +L++DY+SSG+LTHSA  LD+SMK L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

48) CL2_05770 in NC_021016


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  247 bits (924),  Expect = 4e-67, Method: Compositional matrix adjust.
 Identities = 143/275 (52%), Positives = 204/275 (75%), Gaps = 2/275 (0%)

Query  9    INIDEYLMNALKEDITQEDVSTNAVMPEPKQGEVNLICKQDGVICGLEVFERVFKLLDET  68
            ++ID+ L  AL+ED+  ED STNA+  +  Q+ V+L+ K+ GV+ GL VF+RVF L+D  
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   VVFET--ELKDGDKVTKGQLMGVVKGDIRALLSGERVALNYLQRMSGIATMTSELSKELE  126
            V F+   ++KDGD++T G+L+  + G +R+LL+ ERVALN+LQ++SGIA+MT+     L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  GYKTKLLDTRKTTPNMRPFEKYAVTVGGGHNHRYNLSDGVMLKDNHIGAAGGIKEAVAMA  186
            + + K++DTRKTTPN+R FEKYAV VGGG NHR+NLSD++MLKDNHI+A G+++ A+A A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KDYAPFVRKIEVETENLDMVKEAVEAGADIIMLDNMDDETMKEAVKLIDGRAETECSGNV  246
            + YAPFV+ +EVE E+L    EA  AG DIIMLDNM  E + +A+ LI GR+  ECSGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKERLKTIREIGVDYVSCGALTHSAPIMDISLKNL  281
                +  +R +++DYVS G+LTHSA  +D+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

49) FN0010 in NC_003454


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  242 bits (902),  Expect = 2e-65, Method: Compositional matrix adjust.
 Identities = 157/283 (56%), Positives = 215/283 (76%), Gaps = 4/283 (1%)

Query  6    IDKFQMDDSIRMVLKEDITSEDISTNAIYKKDRLAEISLYSKEEGILAGLDVFKRVFELL  65
            +  FQ+DD+++  L+ED+ SED STNAI+  +  A +SL++KE G+LAGL VF+RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  66   DNSVEFT---EYkkdgdkilnkdlilkikANVKTILSAERTALNYLQRMSGIATYTQKMV  122
            D  V F    ++K ++       ++  I ++V+++L+ ER ALN+LQ++SGIA+ T   V
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEII-GSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  123  EALDDKNILLLDTRKTTPNMRIFEKYSVRVGGGYNHRYNLSDAIMLKDNHIDAAGSITEA  182
            EAL+D  I ++DTRKTTPN+R+FEKY+VRVGGGYNHR+NLSDAIMLKDNHI A GS+  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  183  IKLAKEYSPFIKKIEIEVEDLKGVEEAVKAGADIIMLDNMDIETTkkaikiinkkaiiEC  242
            I  A+ Y+PF+K +E+EVE L + EEA  AG DIIMLDNM +E   +AI +I  ++ IEC
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  243  SGNIDITNINRFKGLEIDYVSSGAITHSAKILDLSLKNLRYVD  285
            SGNID+T I+RF+GL IDYVSSG++THSAK LD+S+K L Y+D
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

50) CC1_05300 in NC_021009


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  236 bits (880),  Expect = 1e-63, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 201/277 (73%), Gaps = 4/277 (1%)

Query  7    QLQADKLIRMALEEDITSEDVSTNAVMPTKVQGTVDLIAKEDGVIAGMDVYARVFKLLDE  66
             +Q D  ++ AL ED+ SED STNA+     Q+ V L+AKE GV+AG+ V+ RVF L+D 
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  67   DTEIE---MFCHDGDEVREGDLMAKVTGDIRVLLSGERVALNYLQRMSGIATYTRSVAKL  123
            +  ++    F  DGD +  GDL+  + G +R LL+ ERVALN+LQ++SGIA+ T +    
Sbjct  70   EVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  124  LEGSGVTLLDTRKTTPNCRVFEKYAVRVGGGCNHRYNLSDGVLLKDNHIGAAGSITKAIQ  183
            L +  + ++DTRKTTPN R+FEKYAVRVGGG NHR+NLSD+++LKDNHI+A GS+ KAI 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  184  MAKAYAPFVRKIEIETETLEQVAEAVEAGADIIMLDNMTPEVMKQAVALIDGRAQTECSG  243
             A+AYAPFV+ +E+E E+L    EA  AG DIIMLDNM+ E + QA++LI GR++ ECSG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  244  NITKENIARICEIGVDFVSSGALTHSAPILDISMKHL  280
            NI    I+R+  +++D+VSSG+LTHSA  LD+SMK L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

51) ELI_3093 in NC_014624


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  233 bits (868),  Expect = 1e-62, Method: Compositional matrix adjust.
 Identities = 144/275 (53%), Positives = 210/275 (77%), Gaps = 2/275 (0%)

Query  9    INVDEAILSALREDVTSEDISTNAVMREPRQGRAELICKQDGVMAGIGVFRRVFELLDDT  68
            +++D+++ +ALREDV SED STNA+  +  Q++  L+ K+ GV+AG+ VF+RVF L+D  
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   AAFE--LYYEDGDKVSEGTVIGVVTGDIRCLLTGERTALNFLQRMSGIATYTRGLADVLE  126
             +F+    + DGD+++ G ++  + G +R LLT ER ALNFLQ++SGIA+ T +  + L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  GSRTKLLDTRKTTPNMRVFEKYAVKVGGGYNHRYNLSDGILLKDNHIGAAGSVKKAVAMA  186
            + R K++DTRKTTPN+R+FEKYAV+VGGGYNHR+NLSD+I+LKDNHI+A GSV+KA+A A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KEYASFVRKIevevenlemleealeaGADIIMLDNMDNETMRRAVAMVDGRAETECSGNV  246
            + YA+FV+ +EVEVE+L   EEA  AG DIIMLDNM  E + +A++++ GR+  ECSGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TLERLAEIAKIGVDYVSCGALTHSAPILDFSLKNL  281
             +  ++ +  +++DYVS G+LTHSA  LDFS+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

52) CCU_24270 in NC_021018


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  232 bits (864),  Expect = 2e-62, Method: Compositional matrix adjust.
 Identities = 145/278 (53%), Positives = 203/278 (74%), Gaps = 8/278 (2%)

Query  8    LNADKLIMMALQEDITSEDVSTNAVMPKAQKGKVDLICKQDGIIAGLDVYARVFTLLDDS  67
            ++ D  +  AL+ED+ SED STNA+     ++KV L+ K+ G++AGL V+ RVFTL+D  
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD--  68

Query  68   TEVEF-----FCKDGDEVKAGQLMGIVTGDIRVLLSGERVALNYLQRMSGIATYTHEVAE  122
            +EV F     F KDGD + +G+L+  + G +R LL+ ERVALN+LQ++SGIA+ T    E
Sbjct  69   AEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  123  LLKGSKTTLLDTRKATPNCRIFEKYAVRVGGGSNHRYNLSDGVLLKDNHIGAAGSITNAV  182
             L + +  ++DTRK+TPN R+FEKYAVRVGGG NHR+NLSD+++LKDNHI+A GS+ +A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  183  RMAKEYAPFVRKIEVEVETLDQVKEAVEAGADIIMLDNMTTDQMRAAIDLIDGRAETECS  242
              A+ YAPFV+ +EVEVE+L    EA  AG DIIMLDNM+ +Q+  AI LI GR+  ECS
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  243  GNVTKENIERLVSLGVDYISSGALTHSSPIMDISMKNL  280
            GN+    I R+ +L++DY+SSG+LTHS+  +D+SMK L
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

53) HMPREF0389_00714 in NC_016630


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  231 bits (862),  Expect = 3e-62, Method: Compositional matrix adjust.
 Identities = 156/273 (58%), Positives = 211/273 (78%), Gaps = 2/273 (0%)

Query  11   IDDLLRAAIREDVNGEDVSTQAVSERGTTCQVDLICKEDGVLAGIPVFMRVFELLDSKVS  70
            IDD L+AA+REDV++ED ST+A+ ++    +V L+ KE GVLAG+ VF RVF L+D+ V+
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   FDFSVE--DGASVKKGQILGSVIGSVETLLTGERVALNYLQRMSGIATYTRKMVDALGDD  128
            F+ + +  DG  +  G+++  +IGSV +LLT ERVALN+LQ++SGIA+ T   V+ALGDD
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  RTKIVDTRKTTPLMRPFEKYAVRIGGGENHRYNLSDGVLLKDNHIGMAGSVTAAVTQARR  188
            R K+ DTRKTTP +R FEKYAVR+GGG NHR+NLSD+++LKDNHI+  GSV  A++QAR 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  YAPFVRKIevevetmemvqeavDARADIIMLDNMTIEEIREAIAYINGRAMVELSGNISM  248
            YAPFV+ +EVEVE++   +EA  A  DIIMLDNM++E+I +AI+ I GR+ +E SGNI M
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  249  NNIHEYRGLGADVISSGALTHSAPVLDFSLKGL  281
              I  +RGL+ D +SSG+LTHSA  LDFS+KGL
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

54) Clocel_2166 in NC_014393


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  231 bits (862),  Expect = 3e-62, Method: Compositional matrix adjust.
 Identities = 145/280 (52%), Positives = 209/280 (75%), Gaps = 5/280 (1%)

Query  1    MNQLVVDDIILNALKEDIPNTDISCEGIISKESLAEVDLLAKEEGILAGLDIFKRVFILL  60
            +  + +DD +  AL+ED+ + D S ++I+  ++ A V L+AKE G+LAGL +F+RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   GDVEVEFYK----KDGDTVVFGDKIGKLRGNTRNILMGERTALNLLQRLCGIATLTSLYV  116
             D EV F +    KDGD +  GD +  + G+ R++L  ER ALN+LQ+L GIA++T+ YV
Sbjct  68   -DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  117  EAVSGTKAKVLDTRKTTPNLRVLEKYAVTVGGGYNHRFNLSDGVLLKDNHIEAAGGVKKS  176
            EA+++ + KV+DTRKTTPNLR++EKYAV VGGGYNHRFNLSD+++LKDNHI A G+V+K+
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  177  VELAKKASPFVRKIEVEVESLEMVNEALEAGADIIMLDNMGLDTIKKAVSLIADKAIIEV  236
            +  A+  +PFV+ +EVEVESL   +EA  AG DIIMLDNM+L+ I +A++LIA+++ IE 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  237  SGNVSLDNIGLLAKTGVDYISIGKLTHSAKILDLSMKNLK  276
            SGN+ +  I+ +   ++DY+S G LTHSAK LD+SMK L 
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

55) MHY_05050 in NC_021041


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  231 bits (860),  Expect = 5e-62, Method: Compositional matrix adjust.
 Identities = 145/268 (55%), Positives = 197/268 (74%), Gaps = 6/268 (2%)

Query  17   ALQEDITSEDVTTNAIMPEKVLGEVDLICKGEGVIAGLNVFARTFELLDKDTEIIFMA--  74
            AL+ED+ SED +TNAI  +   + V L+ K  GV+AGL VF R F L+D  +E+ F    
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD--AEVTFQNPH  77

Query  75   --KDGDKVNKGDLLAKVKGDIRVLLSGERVALNYLQRMSGIATYTNQVVNLLVGSKTKLL  132
              KDGD++  GDL+  + G +R LL+ ERVALN+LQ++SGIA+ T   V+ L + + K++
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  133  DTRKTTPNMRIFEKYAVIVGGGNNHRYNLSDGILLKDNHIGAAGSVKKAIELARAYAPFV  192
            DTRKTTPN+R+FEKYAV VGGG NHR+NLSD+I+LKDNHI+A GSV+KAI  ARAYAPFV
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  193  RKIEVETENLDMVKEAIEARADIIMLDNMSIDMMEEAIKLIDGKAQTECSGNVTKENIQA  252
            + +EVE E+L    EA  A  DIIMLDNMS++ +E+AI LI G+++ ECSGN+    I  
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISR  257

Query  253  LAKIGVDFISSGALTHSAPILDLSLKHL  280
            +  +++D++SSG+LTHSA  LD+S+K L
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

56) ROI_23650 in NC_021040


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  230 bits (856),  Expect = 1e-61, Method: Compositional matrix adjust.
 Identities = 146/272 (54%), Positives = 194/272 (72%), Gaps = 5/272 (1%)

Query  22   ALEEDIHSEDVSTNAVMPEYKAGEVELICKQDGVIAGLPVFERVFTMLDASTKVEWAKNQ  81
            AL ED+HSED STNA+  +   + V L+ K+ GV+AGL VF+RVFT++DA         Q
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF-----Q  74

Query  82   DGREVKDGDAVKKGQLLATVKGDVRVLLSGERTALNYLQRLSGIATYTHQVARLLEGSST  141
            + ++ KDGD +  G+L+  + G VR LL+ ER ALN+LQ+LSGIA+ T      L +   
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  142  TLLDTRKTTPCMRIFEKYAVCVGGGQNHRYNLSDGVLLKDNHIDAAGGVKEAILAAKAYA  201
             ++DTRKTTP +R+FEKYAV VGGG NHR+NLSD+++LKDNHI A G+V+ AI  A+AYA
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  202  PFVRKIEVETENLDMVKEAVEAGADIIMLDNMTPEQMAEAIRLIDGRAKTECSGNITKEN  261
            PFV+ +EVE E+L    EA  AG DIIMLDNM+ EQ+ +AI LI GR++ ECSGNI    
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  262  IKTITALGVDYVSSGALTHSAPILDISLKHLK  293
            I  + +L++DYVSSG+LTHSA  LD+S+K L 
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

57) RO1_13890 in NC_021012


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  230 bits (856),  Expect = 1e-61, Method: Compositional matrix adjust.
 Identities = 146/275 (54%), Positives = 196/275 (72%), Gaps = 5/275 (1%)

Query  9    IRLALEEDIHSEDVSTNAVMPEYRAGEVELICKQDGVIAGLPVFERVFTMLDASTKVEWA  68
            ++ AL ED+HSED STNA+  +   + V L+ K+ GV+AGL VF+RVFT++DA       
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF---  73

Query  69   KNQDGREVKDGDAVKKGQLLATVKGDVRVLLSGERTALNYLQRLSGIATYTHQVARLLEG  128
              Q+ ++ KDGD +  G+L+  + G VR LL+ ER ALN+LQ+LSGIA+ T      L +
Sbjct  74   --QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  SSTTLLDTRKTTPCMRIFEKYAVCVGGGQNHRYNLSDGVLLKDNHIDAAGGVKEAILAAK  188
                ++DTRKTTP +R+FEKYAV VGGG NHR+NLSD+++LKDNHI A G+V+ AI  A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  AYAPFVRKIEVETENLDMVKEAVEAGADIIMLDNMTPEQMSEAIRLIDGRAKTECSGNIT  248
            AYAPFV+ +EVE E+L    EA  AG DIIMLDNM+ EQ+ +AI LI GR++ ECSGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  KENIKTITALGVDYVSSGALTHSAPILDISLKHLK  283
               I  + +L++DYVSSG+LTHSA  LD+S+K L 
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

58) nadC in NC_015278


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  230 bits (856),  Expect = 1e-61, Method: Compositional matrix adjust.
 Identities = 142/274 (52%), Positives = 209/274 (77%), Gaps = 3/274 (1%)

Query  18   IDELITLAFKEDIPYEDLSTNAIYQGQA-AQVELLAKQAGVVCGLDLFKQVFLHLDPEVQ  76
            ID+ +  A++ED+  ED STNAI++ ++ A+V L+AK+AGV+ GL +F++VF  +D+EV 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  77   FES--LVRDGDRVAKQETLMVVKASVNTLLSGERIALNFLQRMSGIATATRRFVDALEGS  134
            F++    +DGDR++  + ++ + +SV +LL+ ER+ALNFLQ++SGIA+ T  +V+AL + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  135  GIKLLDTRKTTPAYRPLEKYAVRVGGGYNHRYSLSDQIMLKDNHVAAAGGVKEAIQAAKA  194
             IK++DTRKTTP  R +EKYAVRVGGGYNHR++LSD IMLKDNH+AA G+V+ AI  A+A
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  195  YAPFVKKIEIEVEDLDMVRAVVEAGADVIMLDNMDHDTMEEAIAIINGQAIIEASGNFTW  254
            YAPFVK +E+EVE L        AG D+IMLDNM  + +E+AI++I G++ IE SGN+  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  255  DNVADYKDLAIDYISSGAITHSAGILDLSLKHLK  288
              ++ +++LAIDY+SSG++THSA  LD+S+K L 
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

59) HMPREF0946_01874 in NC_022196


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  229 bits (853),  Expect = 1e-61, Method: Compositional matrix adjust.
 Identities = 157/283 (56%), Positives = 213/283 (76%), Gaps = 4/283 (1%)

Query  6    IDKFQIDNSIKMALKEDITSEDISTNAIYKNDKLAEISLYSKEEGILAGLDVFKRVFELL  65
            +  FQID+++K AL+ED+ SED STNAI+ ++  A +SL++KE G+LAGL VF+RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  66   DNSVEFI---EYkkdgdnllnkdlilkikanikTILFAERTALNYLQRMSGIATYTRKMV  122
            D  V F    ++K ++       ++  I +   ++L  ER ALN+LQ++SGIA+ T   V
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVR-SLLTCERVALNFLQHLSGIASMTAAYV  126

Query  123  EALDDKNILLLDTRKTTPNMRIFEKYSVRVGGGYNHRYNLSDAIMLKDNHIDAAGSITEA  182
            EAL+D  I ++DTRKTTPN+R+FEKY+VRVGGGYNHR+NLSDAIMLKDNHI A GS+  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  183  IKLAKEYSPFIKKIEIEVEDLKGVEEAVKTGADIIMLDNMDiettkkaikiinkqaiieC  242
            I  A+ Y+PF+K +E+EVE L + EEA  +G DIIMLDNM +E   +AI +I  ++ IEC
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  243  SGNIDITNINRFKGLKIDYVSSGAITHSAKILDLSLKNLRYVD  285
            SGNID+T I+RF+GL IDYVSSG++THSAK LD+S+K L Y+D
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

60) CIY_04240 in NC_021031


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  229 bits (854),  Expect = 1e-61, Method: Compositional matrix adjust.
 Identities = 134/277 (49%), Positives = 198/277 (72%), Gaps = 4/277 (1%)

Query  7    TLNADELIKMALREDISSEDVTTNSVMPEAQPGEVELICKQDGIICGMDVYERVFKILDE  66
             ++ D+ +K ALRED+ SED +TN++  +   + V L+ K+ G++ G+ V++RVF ++D 
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  67   STVVEK---YVKDGDEVKKGQLMGKVKGDIRVLLSGERVALNYLQRMSGIATYTNQVASL  123
                ++   + KDGD +  G+L+  + G +R LL+ ERVALN+LQ++SGIA+ T      
Sbjct  70   EVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  124  LKGSKTVLLDTRKTTPNMRIFEKYAVKCGGGQNHRYNLSDGILLKDNHIGAAGSITKAIE  183
            L + +  ++DTRKTTPN+R+FEKYAV+ GGG NHR+NLSD+I+LKDNHI+A GS+ KAI 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  184  MAKAYAPFVRKIEIETETLDQVKEAVEAGADIIMLDNMDVATMKEAVKIIDGRAKTECSG  243
             A+AYAPFV+ +E+E E+L    EA  AG DIIMLDNM +  + +A+ +I GR++ ECSG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  244  NVTKENIANIIDSGVDYVSSGALTHSAPILDISMKNL  280
            N+    I+ + + ++DYVSSG+LTHSA  LD+SMK L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

61) nadC in NC_008593


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  229 bits (852),  Expect = 2e-61, Method: Compositional matrix adjust.
 Identities = 138/281 (50%), Positives = 204/281 (73%), Gaps = 3/281 (1%)

Query  1    MNWFIIDKFLIEALKEDNFYEDITTEAIVGKSSIASVDLIAKEEGIIAGLNVFERVFTLL  60
            +  F ID  L  AL+ED   ED +T+AI +  + A V L+AKE G++AGL VF+RVFTL+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   G---NVEVKALVKDGDEVSSSQLIAKIKGNTRSILTGERVALNMLQKISGIATITNKFVK  117
            +     +     KDGD ++S++L+  I G+ RS+LT ERVALN LQ +SGIA++T  +V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  118  EIKGTKAKLLDTRKTTPNLRVFEKYAVKVGGGYNHRFSLSDGVLIKDNHIDAAGGIKKAI  177
             + + + K++DTRKTTPNLR+FEKYAV+VGGGYNHRF+LSD++++KDNHI A G+++KAI
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  178  ELVRNSVSFVRKIEVEVENLTGVQKALESKADIIMLDNMDIDAMKKAVKMINGKAIVEAS  237
               R   +FV+ +EVEVE+L++ + A  +  DIIMLDNM ++ + +A+ +I G++ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  238  GNVNLKTIRDIANTGVDYISCGIITHSAKALDISMKNLVLL  278
            GN+++ TI  +   ++DY+S G +THSAK+LD+SMK L  L
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

62) CDBI1_11460 in NC_017179


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  227 bits (846),  Expect = 5e-61, Method: Compositional matrix adjust.
 Identities = 142/275 (52%), Positives = 206/275 (75%), Gaps = 7/275 (2%)

Query  6    IDRMIQDALIEDVPSEDITTNSIVDENSKSTVDLICKQDGIIAGLGVFKRVFEILGDVDV  65
            ID  ++ AL EDV SED +TN+I D+++++ V L+ K+ G++AGL VF+RVF ++ D +V
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   KL-----YKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYLQRMSGIATITSRYVEKLE  120
             +     +K DGDR+ + + +  + GS R+LL  ERVALN+LQ++SGIA++T+ YVE L 
Sbjct  72   TFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  GTNTKLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGILLKDNHIGAAGSVKKAVELA  180
            +   K++D+RKT PNLR+++KY+V+VGGG NHRFNLSD+I+LKDNHI+A GSV+KA+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKNTSFVRKIEVEVETLDMVKEAIEANADIIMLDNMSLEMAKQAVDIINGRAIVEFSGNV  240
            R  ++FV+ +EVEVE+L    EA  A  DIIMLDNMSLE   QA+ +I GR+ +E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  NLDTIEDIGKIGVDVVSVGALTHSVKALDISMKNL  275
            ++ TI  +  +++D VS G+LTHS K+LD+SMK L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

63) nadC in NC_013315


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  227 bits (846),  Expect = 5e-61, Method: Compositional matrix adjust.
 Identities = 142/275 (52%), Positives = 206/275 (75%), Gaps = 7/275 (2%)

Query  6    IDRMIQDALIEDVPSEDITTNSIVDENSKSTVDLICKQDGIIAGLGVFKRVFEILGDVDV  65
            ID  ++ AL EDV SED +TN+I D+++++ V L+ K+ G++AGL VF+RVF ++ D +V
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   KL-----YKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYLQRMSGIATITSRYVEKLE  120
             +     +K DGDR+ + + +  + GS R+LL  ERVALN+LQ++SGIA++T+ YVE L 
Sbjct  72   TFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  GTNTKLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGILLKDNHIGAAGSVKKAVELA  180
            +   K++D+RKT PNLR+++KY+V+VGGG NHRFNLSD+I+LKDNHI+A GSV+KA+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKNTSFVRKIEVEVETLDMVKEAIEANADIIMLDNMSLEMAKQAVDIINGRAIVEFSGNV  240
            R  ++FV+ +EVEVE+L    EA  A  DIIMLDNMSLE   QA+ +I GR+ +E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  NLDTIEDIGKIGVDVVSVGALTHSVKALDISMKNL  275
            ++ TI  +  +++D VS G+LTHS K+LD+SMK L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

64) nadC in NC_013316


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  227 bits (846),  Expect = 5e-61, Method: Compositional matrix adjust.
 Identities = 142/275 (52%), Positives = 206/275 (75%), Gaps = 7/275 (2%)

Query  6    IDRMIQDALIEDVPSEDITTNSIVDENSKSTVDLICKQDGIIAGLGVFKRVFEILGDVDV  65
            ID  ++ AL EDV SED +TN+I D+++++ V L+ K+ G++AGL VF+RVF ++ D +V
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   KL-----YKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYLQRMSGIATITSRYVEKLE  120
             +     +K DGDR+ + + +  + GS R+LL  ERVALN+LQ++SGIA++T+ YVE L 
Sbjct  72   TFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  GTNTKLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGILLKDNHIGAAGSVKKAVELA  180
            +   K++D+RKT PNLR+++KY+V+VGGG NHRFNLSD+I+LKDNHI+A GSV+KA+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKNTSFVRKIEVEVETLDMVKEAIEANADIIMLDNMSLEMAKQAVDIINGRAIVEFSGNV  240
            R  ++FV+ +EVEVE+L    EA  A  DIIMLDNMSLE   QA+ +I GR+ +E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  NLDTIEDIGKIGVDVVSVGALTHSVKALDISMKNL  275
            ++ TI  +  +++D VS G+LTHS K+LD+SMK L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

65) ERE_20810 in NC_021044


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  226 bits (841),  Expect = 1e-60, Method: Compositional matrix adjust.
 Identities = 144/269 (54%), Positives = 199/269 (74%), Gaps = 6/269 (2%)

Query  17   SALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFERVFTLLDADTKVE----  72
            +AL+ED+ SED STN++  H   + V L+ K+ G++ GL VF+RVFTL+DA+   +    
Sbjct  19   AALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  73   FYVKDGDRVENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQVAALLEGTGIRL  132
            F  KDGDR+ + +L+  + G +R LL  ER ALN+LQ++SGIA+ T+     L +  I++
Sbjct  79   F--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  133  LDTRKTTPNNRIFEKYSVRVGGGNNHRYNLSDGVLLKDNHIGAAGGVKEAIAMAKAYAPF  192
            +DTRKTTPN R+FEKY+VRVGGG NHR+NLSD+++LKDNHI+A G+V+ AIA A+AYAPF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  193  VRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEIEVSGNVTKENIA  252
            V+ +EVEVES+    +A  AG DIIMLDNMS E + Q I  I GR+ IE SGN+    I+
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  253  RIKGLGVDYVSSGALTHSAPIMDLSLKNL  281
            R++GL++DYVSSG+LTHSA  +D+S+K L
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

66) nadC in NC_009089


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  226 bits (844),  Expect = 7e-61, Method: Compositional matrix adjust.
 Identities = 140/271 (52%), Positives = 204/271 (76%), Gaps = 7/271 (2%)

Query  2    IQDALIEDVPSEDITTNSIVDENSKSTVDLICKQDGIIAGLGVFKRVFEILGDVDVKL--  59
            ++ AL EDV SED +TN+I D+++++ V L+ K+ G++AGL VF+RVF ++ D +V +  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEVTFQN  75

Query  60   ---YKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYLQRMSGIATITSRYVEKLEGTNT  116
               +K DGDR+ + + +  + GS R+LL  ERVALN+LQ++SGIA++T+ YVE L +   
Sbjct  76   PHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  117  KLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGILLKDNHIGAAGSVKKAVELARKNT  176
            K++D+RKT PNLR+++KY+V+VGGG NHRFNLSD+I+LKDNHI+A GSV+KA+  AR  +
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  177  SFVRKIEVEVETLDMVKEAIEANADIIMLDNMSLEMAKQAVDIINGRAIVEFSGNVNLDT  236
            +FV+ +EVEVE+L    EA  A  DIIMLDNMSLE   QA+ +I GR+ +E SGN+++ T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  237  IEDIGKIGVDVVSVGALTHSVKALDISMKNL  267
            I  +  +++D VS G+LTHS K+LD+SMK L
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

67) EUBREC_1035 in NC_012781


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  226 bits (844),  Expect = 8e-61, Method: Compositional matrix adjust.
 Identities = 145/269 (54%), Positives = 199/269 (74%), Gaps = 6/269 (2%)

Query  17   SALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFERVFTLLDADTKVE----  72
            +AL+ED+ SED STN++  H   + V L+ K+ G++ GL VF+RVFTL+DA+   +    
Sbjct  19   AALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  73   FYVKDGDRVENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQVAALLEGTGIKL  132
            F  KDGDR+ + +L+  + G +R LL  ER ALN+LQ++SGIA+ T+     L +  IK+
Sbjct  79   F--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  133  LDTRKTTPNNRIFEKYSVRVGGGNNHRYNLSDGVLLKDNHIGAAGGVKEAIAMAKAYAPF  192
            +DTRKTTPN R+FEKY+VRVGGG NHR+NLSD+++LKDNHI+A G+V+ AIA A+AYAPF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  193  VRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEIEVSGNVTKENIA  252
            V+ +EVEVES+    +A  AG DIIMLDNMS E + Q I  I GR+ IE SGN+    I+
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  253  RIKGLGVDYVSSGALTHSAPIMDLSLKNL  281
            R++GL++DYVSSG+LTHSA  +D+S+K L
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

68) EUR_20660 in NC_021010


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  226 bits (844),  Expect = 8e-61, Method: Compositional matrix adjust.
 Identities = 145/269 (54%), Positives = 199/269 (74%), Gaps = 6/269 (2%)

Query  17   SALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFERVFTLLDADTKVE----  72
            +AL+ED+ SED STN++  H   + V L+ K+ G++ GL VF+RVFTL+DA+   +    
Sbjct  19   AALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  73   FYVKDGDRVENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQVAALLEGTGIKL  132
            F  KDGDR+ + +L+  + G +R LL  ER ALN+LQ++SGIA+ T+     L +  IK+
Sbjct  79   F--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  133  LDTRKTTPNNRIFEKYSVRVGGGNNHRYNLSDGVLLKDNHIGAAGGVKEAIAMAKAYAPF  192
            +DTRKTTPN R+FEKY+VRVGGG NHR+NLSD+++LKDNHI+A G+V+ AIA A+AYAPF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  193  VRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEIEVSGNVTKENIA  252
            V+ +EVEVES+    +A  AG DIIMLDNMS E + Q I  I GR+ IE SGN+    I+
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  253  RIKGLGVDYVSSGALTHSAPIMDLSLKNL  281
            R++GL++DYVSSG+LTHSA  +D+S+K L
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

69) nadC in NC_010723


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  225 bits (837),  Expect = 3e-60, Method: Compositional matrix adjust.
 Identities = 133/278 (48%), Positives = 205/278 (74%), Gaps = 5/278 (1%)

Query  6    VDKIIKEALLEDIPNEDITTNSIIKESSICTVDLLCKEEGILSGLEVFKRVFDILGNVQI  65
            +D  +K AL ED+ +ED +TN+I+ + +   V L+ KE G+L+GL VF+RVF ++ + ++
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFNK----KDGDKICSGEKIALLKGDARNVLLGERVALNLLQRMSGISTLTNKFVNKIEH  121
             F++    KDGD++ SG+ +  + G  R++L  ERVALN+LQ++SGI+++T  +V+ + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TRAKLLDTRKTTPNLRILEKYSVKIGGGYNHRFNLSDGIMLKDNHINAAGGIKKAVEMCK  181
             R K++DTRKTTPNLR++EKY+V++GGGYNHRFNLSD+IMLKDNHI A G+++KA+   +
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  KNSSFVRKIEVEAETLDMVNEALEAKVDIIMLDNMNLKTAKEAVRIINNRVLIEFSGNVN  241
              ++FV+ +EVE E+L   +EA  A VDIIMLDNM+L    +A+ +I  R  IE SGN++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IDNIKEIAEIGVDYISVGALTHSAKILDLSMKNLSIVD  279
            +  I  +  +++DY+S G+LTHSAK LD+SMK L+ +D
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

70) nadC in NC_016826


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  223 bits (830),  Expect = 1e-59, Method: Compositional matrix adjust.
 Identities = 132/275 (48%), Positives = 205/275 (75%), Gaps = 2/275 (0%)

Query  10   LNVDPLILSALSEDINNEDVSTNSVMSENVAGQVDLICKEDGIICGLPVFERVFYLLDPQ  69
            +++D  + +AL ED+++ED STN++  ++  ++V L+ KE G++ GL VF+RVF L+D++
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  70   TKFDV--LVKDGDAVKAGQKLGTVYGDIRVLLSGERTALNYLQRMSGIATYTHEMADLLK  127
              F+     KDGD + +G+ +  + G +R LL+ ER ALN+LQ++SGIA+ T    + L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  128  DSPITLLDSRKTTPNNRIFEKYAVKIGGGKNHRYNLSDGVLLKDNHIGAAGGVKETVLAA  187
            D  I ++D+RKTTPN R+FEKYAV++GGG NHR+NLSD+++LKDNHI+A G+V+ ++  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  188  KDYAPSVRKIEIEVETLEMVKEAVEAGADIIMLDNMDHDQMQEAVALIAGRAEIEISGNV  247
            + YAP V+ +E+EVE+L    EA  AG DIIMLDNM  +Q+++A++LIAGR+ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  248  TKANVASYLDLDVQYISSGALTHSAKILDLSLKNL  282
              + ++ + +L ++Y+SSG+LTHSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

71) CXIVA_12410 in NC_015737


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  223 bits (832),  Expect = 7e-60, Method: Compositional matrix adjust.
 Identities = 138/275 (51%), Positives = 205/275 (75%), Gaps = 2/275 (0%)

Query  9    LNVEPLIKSALKEDITSEDVSTNAVMPRARKGTADLICKEDGVICGLQVFARVFTLLDPA  68
            ++++  +K+AL+ED+ SED STNA+  +  ++   L+ KE GV+ GL VF RVFTL+D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   AEIRLSVQ--DGDQVQKGQKIGVLTGDIRAILSGERTALNFLQRMSGIATYTHQAAELLQ  126
              ++ + Q  DGD++  G+ +  + G +R++L+ ER ALNFLQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  GTGTKLLDTRKTTPNNRIFEKYAVKVGGGNNHRYNLTDGVMLKDNHIGAAGGVAQAVRMA  186
            +   K++DTRKTTPN R+FEKYAV+VGGG NHR+NL+D++MLKDNHI+A G+V +A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  REYAPFVRRIEVEVETLAMVREAVEAGADIIMLDNMDHGTMEQAMAVIGDKAEVEVSGNV  246
            R YAPFV+ +EVEVE+LA   EA  AG DIIMLDNM    +EQA+++I++++ +E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKENIARLADLGVNYISSGALTHSAPILDLSLKNL  281
                I+R+ +L+++Y+SSG+LTHSA  LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

72) nadC in NC_020291


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  223 bits (831),  Expect = 9e-60, Method: Compositional matrix adjust.
 Identities = 138/277 (50%), Positives = 204/277 (74%), Gaps = 5/277 (1%)

Query  7    VDKIIKTALLEDIPNEDITTNSIIDEKSMATVELLCKEEGIIAGLDVFKRVFDILGNVEI  66
            +D  +K+AL ED+ +ED +TN+I+D+ + A V L+ KE G++AGL VF+RVF ++ + E+
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  67   KFCKH----DGESVYPKEKIGLLKGSTRNLLMGERIALNLLQRMSGIATLTNKFVQEIKD  122
             F +     DG+ + + + +  + GS R+LL  ER+ALN+LQ++SGIA++T  +V+ + D
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  123  TNTKLLDTRKTTPNLRTLEKYSVKVGGGCNHRFNLSDGIMLKDNHISAAGGIQKAVMLAR  182
               K++DTRKTTPNLR +EKY+V+VGGG NHRFNLSD+IMLKDNHI+A G++QKA+  AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  183  ENSSFVRKIEVEVENLDMVKEAIEAKADIIMLDNMKLDTAKEAVKLINKRALIEFSGNVE  242
              ++FV+ +EVEVE+L    EA  A  DIIMLDNM L+   +A+ LI  R+ IE SGN++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  243  LGNVKEIADIGVDYISVGALTHSAKILDLSMKNLTLL  279
            +  +  + ++++DY+S G+LTHSAK LD+SMK LT L
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

73) CK5_33430 in NC_021022


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  220 bits (821),  Expect = 5e-59, Method: Compositional matrix adjust.
 Identities = 146/275 (54%), Positives = 202/275 (74%), Gaps = 2/275 (0%)

Query  8    MQADQLIRMALQEDITSEDVSTNAVMPTATKGTVDLIAKEDGVVAGLEIYARVFTILDEK  67
             Q D+ ++ AL+ED+ SED STNA+     ++ V L+AKE GV+AGL ++ RVFT++D  
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  68   TEID--LHCKDGDEVKKGELMATVTGDIRVLLSGERVALNYLQRMSGIATYTRQVAKLLE  125
              ++   + KDGD +  G+L+  + G +R LL+ ERVALN+LQ++SGIA+ T      L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  126  GSNVTLLDTRKTTPNCRVFEKYAVRVGGGHNHRYNLSDGVLLKDNHIgaagsvakavkma  185
            +  + ++DTRKTTPN R+FEKYAVRVGGG NHR+NLSD+++LKDNHI+A GSV KA+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  186  kayaPFVRKIEIEVETLDQVKEAVEAGADIIMLDNMTPEVMKQAVELIDGRAQTECSGNI  245
            +AYAPFV+ +E+EVE+L    EA  AG DIIMLDNM+ E + QA+ LI GR++ ECSGNI
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  246  TKENIQKIREIGVDFVSSGALTHSAPILDISMKNL  280
                I ++R +++D+VSSG+LTHSA  LD+SMK L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

74) KE3_1777 in NC_021900


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  218 bits (812),  Expect = 3e-58, Method: Compositional matrix adjust.
 Identities = 134/275 (49%), Positives = 202/275 (74%), Gaps = 2/275 (0%)

Query  10   LNVDPLILNALSEDINNEDVSTNSVMPENVAGQVDLICKEDGIICGLPVFERVFYLLDPQ  69
            +++D  +  AL ED+++ED STN++  ++  ++V L+ KE G++ GL VF+RVF L+D++
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  70   TKFDV--LVKDGDAVKAGQKLGTVYGDIRVLLSGERTALNYLQRMSGIATYTHEMAELLK  127
              F+     KDGD + +G+ +  + G +R LL+ ER ALN+LQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  128  DSPITLLDSRKTTPNNRIFEKYAVKIGGGKNHRYNLSDGVLLKDNHIGAAGGVKEAVLAA  187
            D  I ++D+RKTTPN R+FEKYAV++GGG NHR+NLSD+++LKDNHI+A G+V+ A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  188  KAYAPSVRKIEIEVETLGMVKEVVEAGADIIMLDNMEHDVMKEAIALIDGRAEIEISGNV  247
            +AYAP V+ +E+EVE+L+   E   AG DIIMLDNM  + + +AI+LI GR+ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  248  TRENLASYADLAVQYVSSGAITHSAKILDLSLKNL  282
                ++ + +LA++YVSSG++THSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

75) nadC in NC_010516


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  218 bits (810),  Expect = 4e-58, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

76) nadC in NC_009697


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (809),  Expect = 4e-58, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRALTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

77) nadC in NC_009495


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (809),  Expect = 4e-58, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRALTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

78) nadC in NC_009698


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (809),  Expect = 4e-58, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRALTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

79) nadC in NC_012658


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (809),  Expect = 4e-58, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRALTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

80) H04402_01516 in NC_017299


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (808),  Expect = 6e-58, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGQKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

81) nadC in NC_015215


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (808),  Expect = 6e-58, Method: Compositional matrix adjust.
 Identities = 130/275 (48%), Positives = 202/275 (74%), Gaps = 2/275 (0%)

Query  9    LNVDPLILSALSEDINNEDVSTNSVMPENVAGQVDLICKEDGIICGLPVFERVFYLLDPT  68
            +++D  + +AL ED+++ED STN++  ++  ++V L+ KE G++ GL VF+RVF L+D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   TTFDV--WVKDGEAVKAGQHLGTVRGDIRVLLSGERTALNYLQRMSGIATYTHEMAELLK  126
             TF+     KDG+ + +G+ +  + G +R LL+ ER ALN+LQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  DSPITLLDSRKTTPNNRIFEKYAVKVGGGKNHRYNLSDGVLLKDNHIGAAGGVKEAVLAA  186
            D  I ++D+RKTTPN R+FEKYAV+VGGG NHR+NLSD+++LKDNHI+A G+V+ A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KNYAPSVRKIEIEVETLEMVKEAVEAGADIIMLDNMDHDTMKKAVAVVNGKAQIEISGNV  246
            + YAP V+ +E+EVE+L    EA  AG DIIMLDNM  + + +A++++ G+++IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKKNLASYVDLNVQYVSSGAITHSAKILDLSLKNL  281
                ++ + +L ++YVSSG++THSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

82) nadC in NC_017576


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (807),  Expect = 7e-58, Method: Compositional matrix adjust.
 Identities = 130/275 (48%), Positives = 201/275 (74%), Gaps = 2/275 (0%)

Query  9    LNVDPLILSALSEDINNEDVSTNSVMPENVAGQVDLICKEDGIICGLPVFERVFYLLDPT  68
            +++D  + +AL ED+++ED STN++  ++  ++V L+ KE G++ GL VF+RVF L+D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   TTFDV--WVKDGEAVKAGQHLGTVRGDIRVLLSGERTALNYLQRMSGIATYTHEMAELLK  126
             TF+     KDG+ + +G+ +  + G +R LL+ ER ALN+LQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  ESPITLLDSRKTTPNNRIFEKYAVKVGGGKNHRYNLSDGVLLKDNHIGAAGGVKEAVLAA  186
            +  I ++D+RKTTPN R+FEKYAV+VGGG NHR+NLSD+++LKDNHI+A G+V+ A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KNYAPSVRKIEIEVETLEMVKEAVEAGADIIMLDNMDHDTMKEAVTVVNGKAEIEISGNV  246
            + YAP V+ +E+EVE+L    EA  AG DIIMLDNM  + + +A+T++ G++ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKENLASYVDLNVQYVSSGAITHSAKILDLSLKNL  281
                ++ + +L ++YVSSG++THSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

83) nadC in NC_013798


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (807),  Expect = 7e-58, Method: Compositional matrix adjust.
 Identities = 130/275 (48%), Positives = 201/275 (74%), Gaps = 2/275 (0%)

Query  9    LNVDPLILSALSEDINNEDVSTNSVMPENVAGQVDLICKEDGIICGLPVFERVFYLLDPT  68
            +++D  + +AL ED+++ED STN++  ++  ++V L+ KE G++ GL VF+RVF L+D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   TTFDV--WVKDGEAVKAGQHLGTVRGDIRVLLSGERTALNYLQRMSGIATYTHEMAELLK  126
             TF+     KDG+ + +G+ +  + G +R LL+ ER ALN+LQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  ESPITLLDSRKTTPNNRIFEKYAVKVGGGKNHRYNLSDGVLLKDNHIGAAGGVKEAVLAA  186
            +  I ++D+RKTTPN R+FEKYAV+VGGG NHR+NLSD+++LKDNHI+A G+V+ A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KNYAPSVRKIEIEVETLEMVKEAVEAGADIIMLDNMDHDTMKEAVTVVNGKAEIEISGNV  246
            + YAP V+ +E+EVE+L    EA  AG DIIMLDNM  + + +A+T++ G++ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKENLASYVDLNVQYVSSGAITHSAKILDLSLKNL  281
                ++ + +L ++YVSSG++THSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

84) Clole_1593 in NC_015275


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (806),  Expect = 8e-58, Method: Compositional matrix adjust.
 Identities = 136/281 (49%), Positives = 204/281 (73%), Gaps = 3/281 (1%)

Query  6    INNINVDEHILNAIKEDITSEDVTTMAIMKEKQQGEVQLICKEDGILAGLSVFRRTFELL  65
            +  +++D+ +  A++ED+ SED +T AI  +  Q+ V L+ KE G+LAGL+VF+R F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  66   -GNIEMQTS--YKDGNEVKKGEIIASIRGDIRVLLSGERTALNYLQRMSGIASFTHELVE  122
             +++  Q +  +KDG+ +  G+++  I G +R LL+ ER ALN+LQ++SGIAS T   VE
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  123  ElkgtkttlldtrkttPGMRVFEKYAVKVGGGTNHRFNLTDGVLIKDNHIGAAGSITAAV  182
             L + +  ++DTRKTTP +R+FEKYAV+VGGG NHRFNL+D++++KDNHI+A GS+  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  183  RACKAYAPFVRKIEVEVENLDMVKEALEAGADIIMLDNMDLETMKQAVVLIGDRAQTECS  242
               +AYAPFV+ +EVEVE+L    EA  AG DIIMLDNM LE + QA+ LI++R++ ECS
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  243  GNVNKERLKAIAAAGVDYVSCGALTHSSPILDFSLKHLKHI  283
            GN++   +  + + ++DYVS G+LTHS+  LDFS+K L  +
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

85) nadC in NC_015600


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  217 bits (806),  Expect = 9e-58, Method: Compositional matrix adjust.
 Identities = 130/275 (48%), Positives = 201/275 (74%), Gaps = 2/275 (0%)

Query  9    LNVDPLILSALSEDINNEDVSTNSVMPENVAGQVDLICKEDGIICGLPVFERVFYLLDPT  68
            +++D  + +AL ED+++ED STN++  ++  ++V L+ KE G++ GL VF+RVF L+D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   TTFDV--WVKDGEAVKAGQHLGTVRGDIRVLLSGERTALNYLQRMSGIATYTHEMAELLK  126
             TF+     KDG+ + +G+ +  + G +R LL+ ER ALN+LQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  DSPITLLDSRKTTPNNRIFEKYAVKVGGGKNHRYNLSDGVLLKDNHIGAAGGVKEAVLAA  186
            D  I ++D+RKTTPN R+FEKYAV+VGGG NHR+NLSD+++LKDNHI+A G+V+ A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KNYAPSVRKIEIEVETLEMVKEAVEAGADIIMLDNMDHDTMKEAVAVVNGKAEIEISGNV  246
            + YAP V+ +E+EVE+L    EA  AG DIIMLDNM  + + +A++++ G++ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKENLASYVDLNVQYVSSGAITHSAKILDLSLKNL  281
                ++ + +L ++YVSSG++THSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

86) Cbei_0794 in NC_009617


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  216 bits (803),  Expect = 1e-57, Method: Compositional matrix adjust.
 Identities = 138/279 (50%), Positives = 205/279 (74%), Gaps = 7/279 (2%)

Query  7    IDKIIKDALIEDCPSGDITTNSIIGEESISTVELICKEEGIVAGLEVFKRVFDLLGNVEI  66
            ID  +K AL ED  S D +TN+I+++++ + V L+ KE G++AGL VF+RVF L+ + E+
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  67   EF-----YKRDGDNAHVKDRVAFLKGNTRSLLVGERIALNLLQRMSGIATLTNRFIQEIK  121
             F     +K DGD     D V  + G+ RSLL  ER+ALN+LQ++SGIA++T  +++ + 
Sbjct  72   TFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  122  HTNAKLLDTRKTTPNLRILEKYSVKIGGGCNHRFNLSDGIMIKDNHISAAGGIKRAIELT  181
            +   K++DTRKTTPNLR++EKY+V++GGG NHRFNLSD+IM+KDNHI+A G++++AI  +
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  182  RKNSSFVRKIEVETENLEMVQEALLAGADIIMLDNMSLEIAKEAVEIIGKRALIEFSGNV  241
            R  ++FV+ +EVE E+L   +EA  AG DIIMLDNMSLE   +A+ +I+ R+ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  242  ELNNIKEIAEIGVDYISVGALTHSAKILDFSLKNLTLLE  280
            ++  I  +  +++DY+S G+LTHSAK LDFS+K LT L+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

87) nadC in NC_017297


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  215 bits (801),  Expect = 2e-57, Method: Compositional matrix adjust.
 Identities = 146/277 (53%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESILKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++I+ ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

88) nadC in NC_009699


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  215 bits (801),  Expect = 2e-57, Method: Compositional matrix adjust.
 Identities = 146/277 (53%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESILKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++I+ ++ +AK+ L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

89) nadC in NC_007517


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  214 bits (797),  Expect = 4e-57, Method: Compositional matrix adjust.
 Identities = 131/270 (49%), Positives = 194/270 (72%), Gaps = 2/270 (0%)

Query  4    IDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDASVC  63
            ID  +  AL ED+H+ D +T A+      A+  L+AKE+ +LAG+ V  RVFT++DA V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  64   FEARHG--DGARLAAGDLIAELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAGT  121
            F+  H   DG RL++GDL+ E+ G    LL  ERVALN+LQ++ G A++TA YVEA+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  122  RARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVLIKENHIAAAGGISRAVSRARS  181
            R ++ DTRKTTP LR++EKYAVRVGGG NHR  L D++++K+NHIAA G++ +A+++AR+
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  182  YIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVNL  241
            Y P    +EVE ES+A   EA  AG DIIMLDNM L  + +A++LI+GR+ +E SG +++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  242  ETVRGIAEAGVDIISVGALTHSARAMDISM  271
             T+  +   ++D +S G+LTHSA+++D+SM
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

90) RHOM_07325 in NC_015977


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  214 bits (797),  Expect = 5e-57, Method: Compositional matrix adjust.
 Identities = 145/276 (53%), Positives = 203/276 (74%), Gaps = 8/276 (2%)

Query  14   IKMALEEDINSEDVSTNAVMPEYKKGDVQLICKEDGIIAGLQIFERVFTLLDEKTQVEF-  72
            +K AL ED++SED STNA+  +  ++ V L+ KE G++AGL +F+RVFTL+D  ++V F 
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD--AEVTFQ  74

Query  73   ----FVKDGEKVKKGQTLAVVTGDIRVLLSGERTALNYLQRLSGIATYTHSVAKLLEGSK  128
                F KDG+++  G+ +  + G +R LL+ ER ALN+LQ+LSGIA+ T +    L + +
Sbjct  75   NPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  129  TKLLDTRKTTPGMRIFEKYAVRIGGGCNHRYNLSDGVLLKDNHIDaaggvkeavaaakay  188
             K++DTRKTTP +R+FEKYAVR+GGG NHR+NLSD+++LKDNHI A G+V+ A+A A+AY
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  189  aPFVRKIEVETENLDMVKEAVEAGADIIMLDNMTPEQMAEAIRVIDGRAETECSGNITKE  248
            APFV+ +EVE E+L    EA  AG DIIMLDNM+ EQ+ +AI +I GR+  ECSGNI   
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  249  NIKTITSLGVDYVSSGALTHSAPILDISLKHLRVLE  284
             I  + +L++DYVSSG+LTHSA  LD+S+K L  L+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

91) Olsu_1386 in NC_014363


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  214 bits (796),  Expect = 6e-57, Method: Compositional matrix adjust.
 Identities = 145/279 (52%), Positives = 201/279 (73%), Gaps = 0/279 (0%)

Query  8    LQAEPLILSALREDITSEDVSTAAVMPEARPGQVRLIAKQEGVICGLDVFLRTFQlldaa  67
            +Q +  + +ALRED+ SED ST A+  +   ++V L+AK+ GV+ GL VF R F L+DA 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  68   atlapaaGVREGAEVTCGQELGVLAADVRALLSGERVALNYLQRMSGIATKTRRMATLLA  127
             T+  +   ++G  +T G+ +  + + VR+LL+ ERVALN+LQ++SGIA+ T      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  128  ASKTRLVDTRKTCPNMRVFEKEAVRVGGGGNHRFNLSDGVMLKDNHIDAAGGVAEAIRLA  187
              + ++ DTRKT PN+R+FEK AVRVGGG NHRFNLSD++MLKDNHI A G+V  AI  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  188  RAHAPFVRKIEVEVESLLQVREAADAGADIIMLDNMDHDTMAQAIAVIGGRARVEASGNV  247
            RA APFV+ +EVEVESL    EAA AG DIIMLDNM  + + QAI++I+GR+R+E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  248  DEEGLAALADLGVDYVSSGALTHSAPILDLSLKHLVVLD  286
            D   ++ + +L++DYVSSG+LTHSA  LD+S+K L  LD
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

92) GM18_1909 in NC_014973


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  213 bits (792),  Expect = 9e-57, Method: Compositional matrix adjust.
 Identities = 132/271 (49%), Positives = 191/271 (71%), Gaps = 2/271 (0%)

Query  3    QIDNIIDNALAEDIHTGDITTLSVVASPRRMRARLVAKEAMVLSGIDVARRVFARLDADI  62
            QID+ +  AL ED+H+ D +T ++     + +  L AKEA VL+G+ V +RVF+ +DA++
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  63   TF-TPH-FQDGARLEQGNIIAVMEGSAASLLQGERVSLNLLQRMSGIATQTAAYVEELEG  120
            TF  PH F+DG RL  G+++  + GS  SLL  ERV+LN+LQ++SGIA+ TAAYVE L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  121  TGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVLIKENHIAAAGGIPEAVRAAR  180
               +V DTRKTTP LR++EKY+VRVGGG NHR  L D++++K+NHIAA G++  A+  AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  181  AYIPHTLKIEVETETLDEVKQALDAGADIIMLDNMSLEQMTEAVQIINKRALVEASGGVN  240
            AY P    +EVE E+L    +A  AG DIIMLDNMSLEQ+ +A+ +I  R+ +E SG ++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  241  LKTIRSIALTGVDIISVGALTHSVRATDISM  271
            + TI  +   ++D +S G+LTHS ++ D+SM
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

93) nadC in NC_016894


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  210 bits (782),  Expect = 6e-56, Method: Compositional matrix adjust.
 Identities = 139/270 (52%), Positives = 201/270 (75%), Gaps = 4/270 (1%)

Query  8    ALKEDITSEDITTNAVIQAGVRGQVQLIAKAAGMIAGLAVFQRVFELLDDAVVM---RKY  64
            AL+ED+ SED +TNA+++   +++V L+AK AG++AGL+VFQRVF L+D  V     +++
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  65   KNDGDLVKPGEIIAEVEAEARTLLTGERTALNYLQRMSGIATHTQKVVKCLEGtktklld  124
            K DGD + +G+++ E+ +  R+LLT ER ALN+LQ++SGIA+ T   V  L + + K++D
Sbjct  80   K-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  125  trkttPNMRIFEKYAVTVGGGNNHRYNLSDGILLKDNHINAAGGVKEAILAAQKYAPFVR  184
            TRKTTPN+R+FEKYAV VGGG NHR+NLSD+I+LKDNHI A G+V+ AI  A+ YAPFV+
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  185  KIEVEVENLEMVSEALDAGADIIMLDNMDTDTMKKAINMIAGKAVTECSGNVTEKRLQEL  244
             +EVEVE+L    EA  AG DIIMLDNM  + + +AI +IAG++  ECSGN+    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  245  GDIGVDFISCGALTHSSPILDLSMKNLCIL  274
             ++++D++S G+LTHS+  LD+SMK L  L
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

94) nadC in NC_003366


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  210 bits (781),  Expect = 7e-56, Method: Compositional matrix adjust.
 Identities = 124/278 (45%), Positives = 198/278 (72%), Gaps = 5/278 (1%)

Query  6    VEENVKRALNEDLQYGDITTESVVLDHKIAKVDIIAKEKGVIAGTEVFKMVFKILGDVEV  65
            +++ +K AL ED++  D +T+++  +H  AKV ++AKE GV+AG  VF+ VF ++ D EV
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   DFS----VNDGEEVEKGQHFGQVSGDAKKILMGERVALNYMQRMCGIATLTREFVERLEG  121
             F      +DG+ +  G+   ++ G  + +L  ERVALN++Q++ GIA++T  +VE L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKVKLLDTRKTTPNMRIFEKYAVKVGGGTNHRFGLNDGVMIKDNHIEAAGGIKNAVSLAR  181
             ++K++DTRKTTPN+R+FEKYAV+VGGG NHRF L+D++M+KDNHI A G++++A++ AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  KNSPFVRKIEVEVESIEQLKEALETKADIIMLDNMDIKTLKEAVKLIDNRAEVEASGNVT  241
              +PFV+ +EVEVES+    EA  +  DIIMLDNM +  + +A+ LI  R+ +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  LDNIREIAETGVDFISTGAVTHSFKVLDISMKNFRYID  279
            +  I  +   ++D++S+G++THS K LD+SMK + Y+D
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

95) nadC in NC_016749


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  210 bits (781),  Expect = 8e-56, Method: Compositional matrix adjust.
 Identities = 127/275 (47%), Positives = 200/275 (73%), Gaps = 2/275 (0%)

Query  9    LNVDPLILSALSEDINNEDVSTNSVMPENVVGQVDLICKEDGIICGLSVFERVFYLLDST  68
            +++D  + +AL ED+++ED STN++  ++  ++V L+ KE G++ GL+VF+RVF L+D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   TTFDV--WVKDGEAVKAGQHLGTVRGDIRVLLSGKRTSLNYLQRMSGIATYTHEMAELLK  126
             TF+     KDG+ + +G+ +  + G +R LL+  R +LN+LQ++SGIA+ T    E L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  127  DTPITLLDSRKTTPNNRIFEKYAVKVGGGKNHRYNLSDGVLLKDNHIGAAGGVKEAVLAA  186
            D  I ++D+RKTTPN R+FEKYAV+VGGG NHR+NLSD+++LKDNHI+A G+V+ A+  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  187  KNYAPSVRKIEIEVETIEMVKEAVEAGADIIMLDNMDHDTMKEAVTVVNGKAEIEISGNV  246
            + YAP V+ +E+EVE++    EA  AG DIIMLDNM  + + +A+T++ G++ IE SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  TKENLASYIDLNVQYVSSRAITHSAKILDLSLKNL  281
                ++ + +L ++YVSS ++THSAK LD+S+K L
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

96) nadC in NC_008261


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  210 bits (780),  Expect = 8e-56, Method: Compositional matrix adjust.
 Identities = 126/278 (46%), Positives = 199/278 (72%), Gaps = 5/278 (1%)

Query  6    VEENVKRALNEDLQYGDITTESVVLDHKIAKVDIIAKEKGVIAGTEVFKMVFKILGDVEV  65
            +++ +K AL ED++  D +T+++  +H  AKV ++AKE GV+AG  VF+ VF ++ D EV
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   DFS----VNDGEEVEKGQHFGQVSGDAKKILMGERVALNYMQRMCGIATLTREFVERLEG  121
             F      +DG+ +  G+   ++ G  + +L  ERVALN++Q++ GIA++T  +VE L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKVKLLDTRKTTPNMRIFEKYAVKVGGGTNHRFGLNDGVMIKDNHIEAAGGIKNAVSLAR  181
             ++K++DTRKTTPN+R+FEKYAV+VGGG NHRF L+D++M+KDNHI A G++++A++ AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  KNSPFVRKIEVEVESIEQLNEALEAKADIIMLDNMDIKTLKEAVKLIDNRAEVEASGNVT  241
              +PFV+ +EVEVES+   +EA  A  DIIMLDNM +  + +A+ LI  R+ +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  LDNIMEIAETGVDFISTGSVTHSFKVLDISMKNFRYID  279
            +  I  +   ++D++S+GS+THS K LD+SMK + Y+D
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

97) nadC in NC_011146


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  209 bits (776),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 127/271 (47%), Positives = 192/271 (71%), Gaps = 2/271 (0%)

Query  3    QIDKIIDNALAEDIHTGDITTLSVLRKPRQMRARLVAKEPMVLAGIAVAERVFSRIDASV  62
            QID  +  AL ED+H+ D +T +++    Q +  L AKE+ VLAG++V +RVF+ +DA V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  63   SFKA--EFSDGDSLAKGDVIARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEG  120
            +F+   +F DGD L+ GD++  + G+  SLL  ERV+LN+LQ++ GIA+ TAAYV  L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  121  TGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVLIKENHIAAAGGILQAVSAAR  180
               +V DTRKTTP LR++EKY+VRVGGG NHR  L D++++K+NHIAA G++ +A++ AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  181  AYIAHTLKVEVETENLDQVAQAVEAGADIIMLDNMGLEEMTKAVQMIGKRALVEASGGVN  240
            AY +    VEVE E+L    +A  AG DIIMLDNM+LE++ +A+ +I+ R+ +E SG ++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  241  LQTIKSIAQTGVDIISVGALTHSVRATDISM  271
            + TI  +   ++D +S G+LTHS ++ D+SM
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

98) nadC in NC_008262


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  208 bits (773),  Expect = 3e-55, Method: Compositional matrix adjust.
 Identities = 124/278 (45%), Positives = 197/278 (71%), Gaps = 5/278 (1%)

Query  6    VEENVKRALNEDLQYGDITTESVVLDHKIAKVDIIAKEKGIIAGTEVFKMVFKILGDVEV  65
            +++ +K AL ED++  D +T+++  +H  AKV ++AKE G++AG  VF+ VF ++ D EV
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   DFS----VNDGEEVEKGQHFGQVSGDAKKILMGERVALNYMQRMCGIATLTREFVERLEG  121
             F      +DG+ +  G+   ++ G  + +L  ERVALN++Q++ GIA++T  +VE L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKVKLLDTRKTTPNMRIFEKYAVKIGGGTNHRFGLSDGVMIKDNHIEAAGGIKNAVSLAR  181
             ++K++DTRKTTPN+R+FEKYAV++GGG NHRF LSD++M+KDNHI A G++++A++ AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  KNSPFVRKIEVEVESIEQLKEALEAKADIIMLDNMDIKTLKESVKLIDNRVEVEASGNVT  241
              +PFV+ +EVEVES+    EA  A  DIIMLDNM +  + +++ LI  R  +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  LDNIREIAKTGVDFISTGSVTHSFKVLDISMKNFRYID  279
            +  I  +   ++D++S+GS+THS K LD+SMK + Y+D
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

99) GM21_1902 in NC_012918


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  207 bits (771),  Expect = 4e-55, Method: Compositional matrix adjust.
 Identities = 125/271 (47%), Positives = 191/271 (71%), Gaps = 2/271 (0%)

Query  3    QIDKIIDNALAEDIHTGDITTLSVLRKPRRMRARLVAKEPMVLAGIEVAERVFSRIDAGI  62
            QID  +  AL ED+H+ D +T +++    + +  L AKE+ VLAG+ V +RVF+ +DA +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  63   AFNA--EFSDGDRLAKGDVIARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEG  120
            +F+   +F DGDRL+ GD++  + G+  SLL  ERV+LN+LQ++ GIA+ TAAYV  L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  121  TGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVLIKENHIAAAGGIIEAVSAAR  180
               +V DTRKTTP LR++EKY+VRVGGG NHR  L D++++K+NHIAA G++  A++ AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  181  SYIAHTLKIEVETENLDQVAQALQAGADIIMLDNMGLEEMTKAVQLIGKRALVEASGGVN  240
            +Y +    +EVE E+L    +A  AG DIIMLDNM+LE++ +A+ LI+ R+ +E SG ++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  241  LQTIRSIAQTGVDIISVGALTHSVRATDISM  271
            + TI  +   ++D +S G+LTHS ++ D+SM
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

100) EC1_17550 in NC_021019


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  207 bits (771),  Expect = 5e-55, Method: Compositional matrix adjust.
 Identities = 137/279 (50%), Positives = 202/279 (73%), Gaps = 8/279 (2%)

Query  7    SMNVDGLILQALREDITSEDITTNAIMKKYQEGSVQLICKQDGIIAGLPVFERVFHLTDP  66
            + ++D+ +  ALRED+ SED +TNAI     ++ V L+ K+ G++AGL VF+RVF L D+
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  67   -----KTEVFLFVEDGAEVKNGQQIGEVHGDIRVLLSAERTALNFLQRMSGIATYTHESA  121
                 + + F    DG  + +G+ + E+ G +R LL+ ER ALNFLQ++SGIA+ T    
Sbjct  70   EVTFQNPHQF---KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  122  KLLEGtktklldtrkttPNMRVFEKYAVKVGGGYNHRYNLSDGVLLKDNHIAAAGGITQA  181
              L + + K++DTRKTTPN+R+FEKYAV+VGGGYNHR+NLSD+++LKDNHIAA G++ +A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  182  INLAKEYASFVRKIEIEVENMDMVKEAVEAGADIIMLDNMSIDEMKEAVAYINGRALTEC  241
            I  A+ YA+FV+ +E+EVE++    EA  AG DIIMLDNMS++++ +A++ I GR+  EC
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  242  SGNVTKETIKDLAQIGVDYISSGALTHSAPILDLSLKNL  280
            SGN+   TI  +  +++DY+SSG+LTHSA  LD+S+K L
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

101) nadC in NC_012563


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  207 bits (770),  Expect = 6e-55, Method: Compositional matrix adjust.
 Identities = 145/278 (53%), Positives = 212/278 (77%), Gaps = 7/278 (2%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIG----  61
            +D+ LK+AL+ED+  ED +T++IF ++ +AK+ L+AKE G++AGL VF+RVF L++    
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  62   -DANAQFYIKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEElk  120
             +   QF  KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L 
Sbjct  73   FQNPHQF--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  stktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHINAAGGIKNAITLA  180
              + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  KNNAPFVRKIeveienleqleealDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV  240
            +  APFV+ +EVE+E+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TIEKIKDIANCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
             +  I  +   ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

102) Clocl_4213 in NC_016627


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  205 bits (762),  Expect = 2e-54, Method: Compositional matrix adjust.
 Identities = 121/263 (47%), Positives = 189/263 (72%), Gaps = 2/263 (0%)

Query  15   LKEDMPAGDITTDNIIDENAMSFAKMIAKDSGVIAGLDVAKRVFELLDQDVKFDKHTE--  72
            L+ED+ + D +T+ I+D+++ +   ++AK++GV+AGL V +RVF L+D +V F++  +  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  73   DGQWVSKGDVIATIHGKTRALLKGERTALNILQRLSGIATITRQYADKIKHLKAKVVDTR  132
            DG++++ GD++  I G  R+LL  ER ALN+LQ+LSGIA++T  Y + + + + KV DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  133  KTTPGLRMLEKYAVRVGGGTNHRFCLSDGVLIKDNHIKAAGGIKKAIELVRNKIPHTIKI  192
            KTTP LR++EKYAVRVGGG NHRF LSD++++KDNHI A G+++KAI   R   P    +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  193  EVETETIDQVLEAIDGKADIIMLDNMGLDMMKEAVKIINGKAIVEASGNVTLDTIVEIAE  252
            EVE E++    EA  +  DIIMLDNM+L+ + +A+ +I G++ +E SGN+ + TI  +  
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  253  TGVDIISVGSLTHSVRAFDISMK  275
             ++D +S GSLTHS +++D+SMK
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSMK  283

103) nadC in NC_010520


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  205 bits (761),  Expect = 3e-54, Method: Compositional matrix adjust.
 Identities = 147/277 (54%), Positives = 213/277 (77%), Gaps = 5/277 (1%)

Query  6    VDEILKSALKEDISFEDITTESIFKENKRAKTDLIAKEDGIIAGLEVFKRVFLLIGDADA  65
            +D+ LK+AL+ED+  ED +T++IF ++ +AK  L+AKE G++AGL VF+RVF L+ DA+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   QFY----IKDGEKVHKGEKIATVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEElks  121
             F     +KDG+++  G+ +  ++G+V++LLT ERVALNFLQ++SGIA++T  +VE L  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  tktklldtrkttPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHINAAGGIKNAITLAK  181
             + K++DTRKTTPNLR+FEKYAVR+GGG+NHRF L+D+I++KDNHI A G++++AI+ A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NNAPFVRKIevevenleqleeALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNVT  241
              APFV+ +EVEVE+L   EEA     DIIMLDNMSL+ + +AI +I GR+  E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  IEKIKYIADCGVDYISTGSLTHSFKVLDLSMKNLTYL  278
            +  I  + + ++DY+S+GSLTHS K LD+SMK LTYL
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

104) EUBELI_01429 in NC_012778


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  204 bits (760),  Expect = 4e-54, Method: Compositional matrix adjust.
 Identities = 131/277 (48%), Positives = 204/277 (74%), Gaps = 6/277 (2%)

Query  9    LNVDPLILGALKEDITSEDVSTNSVMPEPKLGEVELICKQDGIICGLQVFARTFELLDED  68
            +++D  + +AL+ED+ SED STN++  +   + V L+ K+ G++ GL VF R F L+D +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  69   VEIT----FFAKDGDEVKKGQKMAVVRGDIRVLLCGERTALNYLQRMSGIATYTNGVakl  124
            V +     F  KDGD +  G+ +  + G +R LL  ER ALN+LQ++SGIA+ T +    
Sbjct  71   VTFQNPHQF--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  125  lagtktkllDTRKTSPNNRIFEKYAVRIGGGNNHRYNLTDGVLLKDNHIGAAGGVKQAVT  184
            L++ + K++DTRKT+PN R+FEKYAVR+GGG NHR+NL+D+++LKDNHI+A G+V++A++
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  185  MAKEYAPFVRKIEVEVENLSMVREAVEAGADIIMLDNMSHEDMREAMNIIGGKALVEVSG  244
             A+ YAPFV+ +EVEVE+L+   EA  AG DIIMLDNMS E++ +A+ +I+G++ +E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  245  NVTKENIAKITDLGVDFVSSGALTHSAPIMDISLKNL  281
            N+    I+++ +L++D+VSSG+LTHSA  +D+S+K L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

105) MELS_2154 in NC_015873


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  203 bits (753),  Expect = 1e-53, Method: Compositional matrix adjust.
 Identities = 143/277 (52%), Positives = 203/277 (74%), Gaps = 6/277 (2%)

Query  8    LQADPLILQALQEDITSEDVTTNAILPKDCQGEAELLCKQDGIIAGLDVFARAFTLLDDK  67
            +Q D  +  AL+ED+ SED +TNAI+  + Q+   L+ K+ G++AGL VF R FTL+D  
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  68   VWFE----FFTKDGDEVHKGQKLAKVVGSMQAILSAERVGLNYLQRMSGIATYTHQVVSL  123
            V F+    F  KDGD +  G+ +  ++GS++++L+ ERV+LN+LQ++SGIA+ T   V  
Sbjct  71   VTFQNPHQF--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  124  LEGTGITLVDTRKTTPNMRVFEKYAVTVGGGKNHRYNLSDGVLLKDNHISaaggvakava  183
            L +  I + DTRKTTPN+R+FEKYAV VGGG NHR+NLSD+++LKDNHI+A G+V KA+A
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  184  lakayaPFVRKIEVETETLDMVREAVEAGADIIMLDNMSHDMMREAIALIDGRAETECSG  243
             A+AYAPFV+ +EVE E+L    EA  AG DIIMLDNMS + + +AI+LI GR+  ECSG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  244  NVTKENIAALADIGVDYISSGALTHSAPILDLSLKHL  280
            N+    I+ + ++++DY+SSG+LTHSA  LD+S+K L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

106) TherJR_0219 in NC_014152


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  202 bits (751),  Expect = 2e-53, Method: Compositional matrix adjust.
 Identities = 131/276 (48%), Positives = 195/276 (71%), Gaps = 2/276 (0%)

Query  2    ELNTFIVDEIIRRALQEDIGTGDITTDAIVPRDHFTKAFIHTKEDGVLAGIFIAERVFSL  61
            +L  F +D+ ++ AL+ED+ + D +T+AI  ++  +K  + +KE GVLAG+ + +RVF+L
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   LSSEVDFKRIKQ--DGDILQAGDILAELYGPARVILTGERVALNFLQRMSGIATKTRRIA  119
            + +EV F+   Q  DGD L +GD++ E+ G+ R +LT ERVALNFLQ++SGIA+ T    
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  GLLSDSGTAVVDTRKTTPGLRALEKYAVYIGGGKNHRFGLYDGVLIKDNHIKVAGGIKKA  179
              L+D    V DTRKTTP LR +EKYAV +GGG NHRF L D++++KDNHI   G+++KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  VEMARAYAPHTIKIEVEVETLAGVKEALEAGADIIMLDNMDIETVKQALVMINGQALVEV  239
            +  ARAYAP    +EVEVE+LA+  EA  AG DIIMLDNM +E + QA+ +I G++ +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  240  SGGLSEDKVPKLAELGVDIISMGALTHSVKALDISL  275
            SG +    ++++  L++D +S G+LTHS K+LD+S+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

107) nadC in NC_018870


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  201 bits (748),  Expect = 3e-53, Method: Compositional matrix adjust.
 Identities = 128/275 (47%), Positives = 185/275 (68%), Gaps = 2/275 (0%)

Query  2    LPLWMIDDVVRRALMEDVGKGDLTTAALVPEGAWAEGVIHSKAEGVLAGTPVALRVFQLL  61
            L    IDD ++ AL EDV   D +T A+  + + A   + +K  GVLAG  V  RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  62   DPNV--EVAQELPDGSQLFPGAVIARIKGAGRALLTGERVALNFLQRLSGIATATERLVK  119
            D++V  + ++++ DG +L +G ++  I G+ R+LLT ERVALNFLQ+LSGIA+ T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  120  MLEGTKARLIDTRKTTPGLRLLEKYAVRVGGGYNHRFGLDGGVLIKDNHIKIAGGITEAI  179
             L + + +++DTRKTTP LRL+EKYAVRVGGGYNHRF L +++++KDNHI   G++  AI
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  180  RRARSSVPHTVKIEVEVESLEQLKEALEAGADVIMLDNMPLDLMREAVRITAGRVPLEAS  239
             +AR+  P    +EVEVESL    EA  AG D+IMLDNM+L+ + +A+ + AGR  +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  240  GGISADAVREVAETGVDLISVGAITHSAAALDISM  274
            G I   ++      ++D +S G++THSA +LD+SM
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

108) Cthe_2354 in NC_009012


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  199 bits (741),  Expect = 1e-52, Method: Compositional matrix adjust.
 Identities = 126/272 (47%), Positives = 190/272 (70%), Gaps = 2/272 (0%)

Query  6    DIDRIIINALREDIPSGDITTDNIIDETSQSEAVLISKDEGVIAGLDVAKKVFLMLDDQV  65
            +ID  +  ALRED+ S D +T+ I+D+ +Q+   L++K+ GV+AGL V ++VF ++D +V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  66   VFEKMVE--DGQTVKRGDIIAKIKGNTRALLKGERTALNLLQRLSGIATKTRQLADKIKD  123
             F++  +  DG+ +  GD++  I G+ R+LL  ER ALN+LQ+LSGIA+ T    + + D
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  124  LPAKLVDTRKTTPGLRVLEKYAVRVGGGYNHRFCLSDGVLIKDNHIKAAGGIKQAVQLVR  183
               K+ DTRKTTP LR++EKYAVRVGGGYNHRF LSD++++KDNHI A G++++A+   R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  184  EKIPHTMKIEVETETIEQVLEALEAKADIIMLDNMSLDEMKKAVKIIDGRAVTEASGNVN  243
               P    +EVE E++    EA  A  DIIMLDNMSL+++ +A+ +I GR+  E SGN++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  244  ADTIYDIACTGVDIISVGGLTHSVKAFDISMK  275
              TI  +   ++D +S G+LTHS K++D+SMK
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

109) Clo1313_3017 in NC_017304


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  199 bits (741),  Expect = 1e-52, Method: Compositional matrix adjust.
 Identities = 126/272 (47%), Positives = 190/272 (70%), Gaps = 2/272 (0%)

Query  6    DIDRIIINALREDIPSGDITTDNIIDETSQSEAVLISKDEGVIAGLDVAKKVFLMLDDQV  65
            +ID  +  ALRED+ S D +T+ I+D+ +Q+   L++K+ GV+AGL V ++VF ++D +V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  66   VFEKMVE--DGQTVKRGDIIAKIKGNTRALLKGERTALNLLQRLSGIATKTRQLADKIKD  123
             F++  +  DG+ +  GD++  I G+ R+LL  ER ALN+LQ+LSGIA+ T    + + D
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  124  LPAKLVDTRKTTPGLRVLEKYAVRVGGGYNHRFCLSDGVLIKDNHIKAAGGIKQAVQLVR  183
               K+ DTRKTTP LR++EKYAVRVGGGYNHRF LSD++++KDNHI A G++++A+   R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  184  EKIPHTMKIEVETETIEQVLEALEAKADIIMLDNMSLDEMKKAVKIIDGRAVTEASGNVN  243
               P    +EVE E++    EA  A  DIIMLDNMSL+++ +A+ +I GR+  E SGN++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  244  ADTIYDIACTGVDIISVGGLTHSVKAFDISMK  275
              TI  +   ++D +S G+LTHS K++D+SMK
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

110) Ilyop_2323 in NC_014633


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  195 bits (725),  Expect = 2e-51, Method: Compositional matrix adjust.
 Identities = 133/277 (49%), Positives = 186/277 (68%), Gaps = 5/277 (1%)

Query  6    IDDIIKNALLEDKVHDDITTESITSLDSKAEIDLISKENGKICGLNVFSRVFEILGDVDI  65
            IDD +K AL ED   +D +T++I   +++A + L++KE G + GL VF RVF ++ D ++
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEV  71

Query  66   NFIK----KEGELVRKGEIIAKLTGCTRVLLSGERVALNLLQRMSGIATAAYEASEILKE  121
             F +    K+G+ +  G+++  + G  R LL+ ERVALN+LQ++SGIA+ +    E L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  YGIKIFDTRKTTPGLRYLEKYSVLTGGGFNHRFDLSDMAMVKDNHILAAGSIKKAVELIR  181
              IK+FDTRKTTP LR +EKY+V  GGG+NHRF+LSD  M+KDNHI A GS++KA+   R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  TIHPFIKKIEVETESLEQVKEAIEAKADIIMLDNMEDELLKECINYINGRAIIEVSGNMD  241
            +  PF+K +EVE ESL    EA  A  DIIMLDNM  E + + I  I GR+ IE SGN+D
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  242  EKRLQNLKKFKIDYVSMGKLTHSVKALDISMKNLKIL  278
               +  ++ + IDYVS G LTHS K+LD+SMK L  L
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

111) nadC in NC_003030


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  191 bits (709),  Expect = 4e-50, Method: Compositional matrix adjust.
 Identities = 126/273 (47%), Positives = 189/273 (70%), Gaps = 5/273 (1%)

Query  7    DDFIKKELIDDGAYNDITTNAIIEESSKSTADIIAKEDGIIAGIGIFKRVFEIFKGAEAE  66
            DD +K  L +D   +D +TNAI+++ +++   ++AKE G++AG+ +F+RVF +F +AE  
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEVT  72

Query  67   FT----ISDGSKVKKGEIIGRVFGSTHSILSGERTALNLMQILSGIATTTSNLNKRLEGT  122
            F     + DG ++  G+++  ++GS +S+L+ ER ALN++Q LSGIA+ T+     L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  123  GVKLLDTRKTTPGMRLLEKYAVKIGGGYNHRFGLSDGILIKDNHIDAAYGITNAVNLARN  182
             +K++DTRKTTP +RL+EKYAV++GGGYNHRF LSD+I++KDNHI A  ++ +A+  AR 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  183  NSSFVRKIEVETETLDEVSEALNAKADIIMLDNMDVETIKKAVKLINKRALIEVSGNITF  242
             ++FV+ +EVE E+L    EA  A  DIIMLDNM +E I +A+ LI  R+ IE SGNI  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  243  ENIREKAVPGVDYISSGMLTHSFNVLDISMKNL  275
              I      ++DY+SSG LTHS + LD+SMK L
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

112) nadC in NC_015687


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  191 bits (709),  Expect = 4e-50, Method: Compositional matrix adjust.
 Identities = 126/273 (47%), Positives = 189/273 (70%), Gaps = 5/273 (1%)

Query  7    DDFIKKELIDDGAYNDITTNAIIEESSKSTADIIAKEDGIIAGIGIFKRVFEIFKGAEAE  66
            DD +K  L +D   +D +TNAI+++ +++   ++AKE G++AG+ +F+RVF +F +AE  
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEVT  72

Query  67   FT----ISDGSKVKKGEIIGRVFGSTHSILSGERTALNLMQILSGIATTTSNLNKRLEGT  122
            F     + DG ++  G+++  ++GS +S+L+ ER ALN++Q LSGIA+ T+     L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  123  GVKLLDTRKTTPGMRLLEKYAVKIGGGYNHRFGLSDGILIKDNHIDAAYGITNAVNLARN  182
             +K++DTRKTTP +RL+EKYAV++GGGYNHRF LSD+I++KDNHI A  ++ +A+  AR 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  183  NSSFVRKIEVETETLDEVSEALNAKADIIMLDNMDVETIKKAVKLINKRALIEVSGNITF  242
             ++FV+ +EVE E+L    EA  A  DIIMLDNM +E I +A+ LI  R+ IE SGNI  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  243  ENIREKAVPGVDYISSGMLTHSFNVLDISMKNL  275
              I      ++DY+SSG LTHS + LD+SMK L
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

113) nadC in NC_017295


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  191 bits (709),  Expect = 4e-50, Method: Compositional matrix adjust.
 Identities = 126/273 (47%), Positives = 189/273 (70%), Gaps = 5/273 (1%)

Query  7    DDFIKKELIDDGAYNDITTNAIIEESSKSTADIIAKEDGIIAGIGIFKRVFEIFKGAEAE  66
            DD +K  L +D   +D +TNAI+++ +++   ++AKE G++AG+ +F+RVF +F +AE  
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-DAEVT  72

Query  67   FT----ISDGSKVKKGEIIGRVFGSTHSILSGERTALNLMQILSGIATTTSNLNKRLEGT  122
            F     + DG ++  G+++  ++GS +S+L+ ER ALN++Q LSGIA+ T+     L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  123  GVKLLDTRKTTPGMRLLEKYAVKIGGGYNHRFGLSDGILIKDNHIDAAYGITNAVNLARN  182
             +K++DTRKTTP +RL+EKYAV++GGGYNHRF LSD+I++KDNHI A  ++ +A+  AR 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  183  NSSFVRKIEVETETLDEVSEALNAKADIIMLDNMDVETIKKAVKLINKRALIEVSGNITF  242
             ++FV+ +EVE E+L    EA  A  DIIMLDNM +E I +A+ LI  R+ IE SGNI  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  243  ENIREKAVPGVDYISSGMLTHSFNVLDISMKNL  275
              I      ++DY+SSG LTHS + LD+SMK L
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

114) Adeg_1872 in NC_013385


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  191 bits (707),  Expect = 5e-50, Method: Compositional matrix adjust.
 Identities = 131/269 (49%), Positives = 190/269 (71%), Gaps = 2/269 (0%)

Query  7    DEIIVRALREDIGPGDITTELLVPPEKTGRGVIFTKEEGVVAGLPVAARVFALLDPRITF  66
            D+ +  ALRED+ + D +T+ +   +  ++  +F+KE GV+AGL V  RVF+L+D+ +TF
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  67   L--PQVEEGARVSKGEVLARVEGPLRGILMGERVALNFLRHLSGIATRTRAVVELVKDYP  124
                Q  +G R++ G+++  + G++R++L  ERVALNFL+HLSGIA+ T A VE + D  
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  125  VRILDTRKTTPGLRSMEKYAVRVGGGSNHRFGLFDGILIKDNHIRAVGSVAEAIRRAREG  184
            ++++DTRKTTP LR  EKYAVRVGGG NHRF L D+I++KDNHI AVGSV  AI +AR  
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  185  APATLKIEVETKSlaeveealaagaDIIMLDNMPVEEMRRAVELVKGRVLLEASGGITEK  244
            AP    +EVE  SLA  EEA AAG DIIMLDNM++E++ +A+ L+ GR  +E SG I   
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  245  NVREVAATGVNFISLGALTHSVKALDISL  273
             +    + +++++S G+LTHS K+LD+S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

115) CCALI_00718 in NC_021487


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  191 bits (708),  Expect = 5e-50, Method: Compositional matrix adjust.
 Identities = 125/267 (47%), Positives = 187/267 (71%), Gaps = 2/267 (0%)

Query  27   VQQALREDIGTGDITTQIVIPSTARAKANITTRVPGVIAGLPVVQEVYRQLDPTVQVQPI  86
            ++ ALRED+ + D +T+ ++   ++AK ++ ++ +GV+AGL V Q V+  +D+ V  Q  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  87   VQ--DGDSVEANTPLATLSGSAQSLLTGERVALNFLQRLSGIATLTAKFVAAARREDVRI  144
             Q  DGD + +   +  + GS +SLLT ERVALNFLQ+LSGIA++TA +V A   + +++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  145  VDTRKTTPGLRLLEKYAVRVGGGHNHRFGLYDAVLIKDNHIAACGSITEAVRTALSSAPH  204
             DTRKTTP LRL+EKYAVRVGGG NHRF L DA+++KDNHIAA GS+  A+  A + AP 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  205  VMSVTVECDTLDQVREALAAGADVILLDNMSPDQLREAVSLVNGQAMIEASGGITLENVA  264
            V  V VE ++L    EA AAG D+I+LDNMS +Q+ +A++L+ G++ IE SG I +  ++
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  265  EVAATGVDIISIGALTHSAPALDIGMD  291
               + ++D +S G+LTHSA +LD++M 
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

116) Calni_1310 in NC_014758


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  190 bits (706),  Expect = 6e-50, Method: Compositional matrix adjust.
 Identities = 126/271 (47%), Positives = 188/271 (70%), Gaps = 2/271 (0%)

Query  6    IDRLINLAIDEDIGKGDLSTDSIKPYLGKGTFEFVAKEEFILCGIDVVRRVFELIDSDVN  65
            ID  ++ A+ ED+   D ST++I    G++   + AKE  +L G+ V +RVF L+D++V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   VHFSR--KDGDRVAKSDIIGSVRGDVSSILKGERIALNFLQRMSGIATNTSYFVEKLKYS  123
             + ++  KDGDR++ +D++  + G V S+L  ER+ALNFLQ++SGIA+ T+ +VE L   
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  124  NIKILDTRKTLPGHRVLEKYSVKTGGGYNHRFGLFDGVMLKDNHIDAVGGIRKAVDIVRR  183
             IK++DTRKT P  R++EKY+V+ GGGYNHRF L D++MLKDNHI AVG+++KA+   R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  184  NIPITVKIEVETRDLDEVKEAVEAGVDIIMLDNFDIEMIYAAADIIRGKSKIEVSGGVTI  243
              P+   +EVE   L    EA  AGVDIIMLDN  +E I  A  +I G+S+IE SG + +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  244  NNIDKYKDLPIDYISVGALTHQARSVDISLK  274
              I ++++L+IDY+S G+LTH A+S+D+S+K
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

117) Acear_1082 in NC_014378


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  190 bits (706),  Expect = 7e-50, Method: Compositional matrix adjust.
 Identities = 127/267 (48%), Positives = 185/267 (70%), Gaps = 2/267 (0%)

Query  14   IDDALAEDIGTGDLTTEAVVDSTQQVQGELIAKEEGVIAGLAVAGLIFERLGAKIDYQ--  71
            +  AL ED+ + D +T+A+ D   Q +  L+AKE GV+AGL+V   +F  ++A + +Q  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  72   QQIEEGVRVRPQTVIATISGLAAPILTGERVALNFLQRLSGIATKTAQYAELVADYDVRI  131
            +Q+ +G R+ +  ++  I G   ++LT ERVALNFLQ+LSGIA+ TA Y E ++D  +++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  132  VDTRKTTPGLRMLEKYAVRVGGGFNHRCGLYDAVLIKDNHIQVVGSITEAVEQAKEGVPH  191
             DTRKTTP LR++EKYAVRVGGG+NHR  L DA+++KDNHI  VGS+  A+ QA+   P 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  192  TVKIEVEVETLAEVKEALASGVDIIMLDNMPPELMEKAVGLIAGQTVTEASGGITAETIK  251
               +EVEVE+LA   EA A+GVDIIMLDNM+ E +E+A+ LIAG++  E SG I   TI 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  252  EVAQAGVDIISLGTLTHTISALDISLR  278
                 ++D +S G+LTH+  +LD+S++
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

118) nadC in NC_020134


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  190 bits (705),  Expect = 7e-50, Method: Compositional matrix adjust.
 Identities = 127/276 (47%), Positives = 184/276 (67%), Gaps = 2/276 (0%)

Query  1    MEKWVIRDILERAFREDMPMGDITTDNTVPCDSISKAFLIAKQDGVIAGLEICIEAFRML  60
            +    I D L  A+RED+   D +T+     ++ +K  L+AK+ GV+AGL +    F ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DPDVNLE--PLVKDGDFVRKGDRILVVEGNSRALLKAERTALNILQRLSGIATETRKYVE  118
            D++V ++     KDGD +  GD +L + G+ R+LL  ER ALN+LQ+LSGIA+ T  YVE
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  KLRGYKAKVVDTRKTTPGLRLLEKYAVRVGGGTNHRFSLSDGVLIKDNHIKAAGGIRQAV  178
             L + + KV DTRKTTP LRL+EKYAVRVGGG NHRF+LSD++++KDNHI A G++++A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  EAVRKQIPHTVKIEVETETLEQVKEALDIGADIIMLDNMPPEIMKQAVELIAGKAVTEAS  238
               R   P    +EVE E+L    EA   G DIIMLDNM+ E + QA+ LIAG++  E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNVTLDNIESVAATGVDIISVGAITHSVKAMDISMK  274
            GN+ +  I    + ++D +S G++THS K++D+SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

119) Clst_2604 in NC_020887


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  190 bits (705),  Expect = 7e-50, Method: Compositional matrix adjust.
 Identities = 127/276 (47%), Positives = 184/276 (67%), Gaps = 2/276 (0%)

Query  1    MEKWVIRDILERAFREDMPMGDITTDNTVPCDSISKAFLIAKQDGVIAGLEICIEAFRML  60
            +    I D L  A+RED+   D +T+     ++ +K  L+AK+ GV+AGL +    F ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DPDVNLE--PLVKDGDFVRKGDRILVVEGNSRALLKAERTALNILQRLSGIATETRKYVE  118
            D++V ++     KDGD +  GD +L + G+ R+LL  ER ALN+LQ+LSGIA+ T  YVE
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  KLRGYKAKVVDTRKTTPGLRLLEKYAVRVGGGTNHRFSLSDGVLIKDNHIKAAGGIRQAV  178
             L + + KV DTRKTTP LRL+EKYAVRVGGG NHRF+LSD++++KDNHI A G++++A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  EAVRKQIPHTVKIEVETETLEQVKEALDIGADIIMLDNMPPEIMKQAVELIAGKAVTEAS  238
               R   P    +EVE E+L    EA   G DIIMLDNM+ E + QA+ LIAG++  E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNVTLDNIESVAATGVDIISVGAITHSVKAMDISMK  274
            GN+ +  I    + ++D +S G++THS K++D+SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

120) Despr_3036 in NC_014972


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  190 bits (704),  Expect = 9e-50, Method: Compositional matrix adjust.
 Identities = 124/276 (45%), Positives = 193/276 (70%), Gaps = 3/276 (1%)

Query  1    MDTFLLDPLLRNLLAEDLEHSDITTEAIFSPEDQAQAYFIARHPMTVVGMETVAARVFRL  60
            +  F +D  L+  L ED++  D +T+AIF  ++QA+  ++A+++  + G+ TV  RVF L
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGL-TVFQRVFTL  66

Query  61   LDPSVVCTDA--VADGTRVETGTALLAISGATRALLRGERVALNLVQRLCGIATLTTAFV  118
            +D+ V   ++    DG R+ +G  +L I G+ R+LL  ERVALN++Q+L GIA++T+A+V
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  119  DAVRHTKATIVDTRKTTPGLRLLEKYAVRASGGRNHRYSLSDGVLIKDNHIAACGSITEA  178
            +A+ + +  + DTRKTTP LRL+EKYAVR +GG NHR++LSD++++KDNHIAA GS+  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  179  VRRVRARVPHTINVEVETDTLAQVEECLACGVGVIMLDNMDLATMRQAVNLIDGRAIIEA  238
            + + RA  P    VEVE ++LA  EE  A GV++IMLDNM L  + QA+ LI GR+ IE 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  239  SGGVNLDTVRGIAETGVDIISVGALTHSARACDIGM  274
            SG +++ T+  +   ++D +S G+LTHSA++ D++M
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

121) Desca_0158 in NC_015565


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  190 bits (704),  Expect = 9e-50, Method: Compositional matrix adjust.
 Identities = 119/276 (44%), Positives = 190/276 (69%), Gaps = 2/276 (0%)

Query  2    ELNMIELKKLIESSLAEDIGTGDITTNSIVPEGSTAKGIIYVKEPGVVAGIPVAEAVFRF  61
            +L  +++   + ++L ED+ + D +TN+I  + + AK  ++ KE+GV+AG+ V + VF +
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   LAPEIEIN--RRSTDGAWVEPGTVLMEVAGDARAILTGERLALNFLQRMSGIATRTAALV  119
            + +E+ ++  ++  DG ++ +G +++E+ G  R++LT ER+ALNFLQ++SGIA+ TAA V
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  EKVKLYPVRVVDTRKTTPGLRMLEKYAVRVGGGFNHRYGLYDAVLIKDNHIKVAGGITQA  179
            E +    ++V DTRKTTP LR++EKYAVRVGGG+NHR+ L DA+++KDNHI   G++ +A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  ILAARQNVPHTVKIEVEVEDLAGVSEALEARADVIMLDNMDPATMREAVKLVDGKALVEA  239
            I  AR   P    +EVEVE LA+  EA  A  D+IMLDNM    + +A+ L+ G++ +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  240  SGGISEETITAVAKTGVDLISVGALTHSVKALDISL  275
            SG I   TI+     ++D +S G+LTHS K+LD+S+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

122) Desru_0243 in NC_015589


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  189 bits (702),  Expect = 2e-49, Method: Compositional matrix adjust.
 Identities = 126/260 (49%), Positives = 181/260 (70%), Gaps = 2/260 (0%)

Query  18   EDIGTGDITTNSTVPIGSRAKGMIYVKEPGVLAGLAVAEEVFRQMSPEVHFH--HRIQDG  75
            ED+ + D +TN+     ++AK  ++ KE+GVLAGL+V + VF    +EV F+  H+++DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  76   TWVEPGTVVAEVEGDARAILTGERLALNFLQRMSGIATRTAALVEKVKLYPVRVVDTRKT  135
             ++ +G +V E+ G  R++LT ER+ALNFLQ++SGIA+ TAA VE +    ++V DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  136  TPGLRMLEKYAVRVGGGFNHRYGLYDAVLIKDNHIKVAGGITQAVLAARHNVPHTIKIEV  195
            TP LR++EKYAVRVGGG+NHR+ L DA+++KDNHI   G++ +A+  AR   P    +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  196  EVEDLAGVSEALEARVDIIMLDNMDQATMREAVKLVDGRALVEASGGINEETIVAAAKAG  255
            EVE LA+  EA  A VDIIMLDNM    + +A+ L+ GR+ +E SG I+  TI      +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  256  VDLVSIGALTHSIKSLDISL  275
            +D VS G+LTHS KSLD+S+
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

123) Btus_0100 in NC_014098


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  188 bits (698),  Expect = 3e-49, Method: Compositional matrix adjust.
 Identities = 125/268 (47%), Positives = 188/268 (71%), Gaps = 2/268 (0%)

Query  10   EVVKRALREDIGYGDVTTRHVVPAGARARGTFRAKSSGVIAGLPVAREVFEVLDPEVTFQ  69
            + +K ALRED+   D +T  +    ++A+ ++ AK +GV+AGL V + VF ++D+EVTFQ
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  70   E--LLREGESVGPGQAVAVVEGRASSILTGERVALNFLQRLSGIATKTAKFVESVRYYHA  127
            +   +++G+ + +G+ V  + G   S+LT ERVALNFLQ+LSGIA+ TA +VE++   + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  128  RITDTRKTTPGLRALEKYAVRVGGGYNHRFGLFDAVLIKDNHIAVAGGVKQAIMAVRRGA  187
            ++ DTRKTTP LR +EKYAVRVGGGYNHRF L DA+++KDNHIA  G+V++AI   R  A
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  188  PHTMKIEVEVETFEQIDEALEVKADIIMLDNMTVEQMKEAVERINGRAVVEASGGVTEEN  247
            P    +EVEVE++   +EA     DIIMLDNM++EQ+ +A+  I GR+ +E SG +    
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  248  VVDIAKTGVDYISVGALTHSSTALDISL  275
            +  +   ++DY+S G+LTHS+ +LD+S+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

124) BN69_0372 in NC_018485


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  188 bits (698),  Expect = 3e-49, Method: Compositional matrix adjust.
 Identities = 119/280 (43%), Positives = 198/280 (71%), Gaps = 5/280 (1%)

Query  3    PDLPPMLIEDAVRAALAEDLGHAGDVTTQATIPRRAQARAGIVARDSGVVaglqaaraaf  62
             DL P  I+D+++AAL ED+ H+ D +T+A + +++QA+ ++ A+++GV+AGL   +  F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  63   aLMDPQIIFEA--QATDGARVEPGTLAAIISGPARPILSAERVALNYLGRLSGVATLTAR  120
            +L D+++ F+   Q  DG R+ +G L   I G+ R++L+ ERVALN+L +LSG+A++TA 
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  121  YVSAVAGTSARICDTRKTTPLLRALEKYAVRCGGGVNHRFGLDDAVLIKDNHVAVAGGVI  180
            YV A+++   ++ DTRKTTP LR +EKYAVR GGG NHRF L DA+++KDNH+A  G+V 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  181  PALSAAKRNIGHLVK-IEVEVDTLDQLREVLHEGADAVLLDNMTLDDLRSAVALVGGRMI  239
             A++ A R  + +VK +EVEV++L    E    G D ++LDNM+L+++  A++L++GR  
Sbjct  185  KAIAQA-RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  240  CEASGGVTLASVTEIAKTGVDFISVGALTHSAPVFDFGLD  279
             E SG + +++++ +   ++D++S G+LTHSA  +DF++ 
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

125) Dred_0165 in NC_009253


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  188 bits (696),  Expect = 4e-49, Method: Compositional matrix adjust.
 Identities = 122/266 (46%), Positives = 185/266 (70%), Gaps = 2/266 (0%)

Query  12   IETSLAEDIGTGDITTNSIVPAECKTKGIIFVKETGIVAGISVAEAVFRYLSPEIGFIA-  70
            + ++L ED+ + D +TN+I   + ++K  +F KE+G++AG++V + VF  + +E+ F   
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  71   -HAKDGDQLEAGQTIAKVEGDARAILTGERLALNFLQRMSGIATRTASLVEKVKLYPVRV  129
             + KDGD+L +G+ +  + G  R++LT ER+ALNFLQ++SGIA+ TA+ VE +    ++V
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  130  VDTRKTTPGLRMLEKYAVRIAGGFNHRFGLNDAVLIKDNHIKVAGGITQAILAARHNVPH  189
             DTRKTTP LR++EKYAVR++GG+NHRF L+DA+++KDNHI   G++ +AI  AR   P 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  190  TIKIEVEVESLAGVIEALDAKADIIMLDNMDHATMREAVKLIDGRALVEASGGVNEETIV  249
               +EVEVESLA+  EA  A  DIIMLDNM    + +A+ LI GR+ +E SG ++  TI 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  250  SVAKTGVDLISVGALTHSIKSLDISL  275
                 ++D +S G+LTHS KSLD+S+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSM  282

126) Desdi_0090 in NC_019903


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  188 bits (697),  Expect = 4e-49, Method: Compositional matrix adjust.
 Identities = 123/275 (45%), Positives = 190/275 (70%), Gaps = 3/275 (1%)

Query  2    LAAFQYQELIEQALQEDLGTGDLSA-AIFPKTAWTRAKIYAKQKGVLCGLEVTKQIFKTV  60
            L++FQ ++ +  AL+ED+ + D S+ AIF   + ++  ++AK+ GVL GL V +++F   
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DAQLDVKILA--KDGEKIERGTVVIEITGPVRSILSAERTALNFLQHLSGVASATYQAVK  118
            DA++  +     KDG+++  G +V+EI G+VRS+L+ ER ALNFLQHLSG+AS T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  ECEGLPTRITDTRKTLPGLRMLQKYAVRMGGGQNHRFGLYDAVMLKDNHIAAAGGIRPAV  178
               +   ++ DTRKT P LR+++KYAVR+GGG NHRF L DA+MLKDNHIAA G+++ A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  EAARHQIGHMVKIEVECETLQQVEEAVASGAEVIMLDNMNLEEMHKAVNIVNGRAILEAS  238
              AR     +  +EVE E+L   EEA A+G ++IMLDNM+LE++++A+ ++ GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGIKKGSVRAVAETGVDVISIGAITHSVKALDFSL  273
            G I   ++      ++D +S G++THS K+LDFS+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

127) Syn7502_03497 in NC_019702


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  187 bits (695),  Expect = 5e-49, Method: Compositional matrix adjust.
 Identities = 122/276 (45%), Positives = 187/276 (68%), Gaps = 7/276 (2%)

Query  8    LDPILESWLREDIGRGDRTTMGLFPNHDAPEGEAVWIAKADGTIAGLPIAQRVFQLLDHA  67
            +D  L + LRED+   D +T ++F +H+  ++    +AK  G +AGL + QRVF L+D  
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHG--QAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  68   VEFKA--LVKDGDRCYAGQKIAEVRGSLATLLTGERVALNLVMRLSGVSTLTQKYVAAIA  125
            V F+     KDGDR  +G+ + E+ GS+ +LLT ERVALN++ +LSG++++T  YV A++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  126  QFPVTLVDTRKSTPGLRLFEKYATYIGGAINHRFGLDDAVMIKDNHIAAAGGIKEAVNRV  185
            +  + + DTRK+TP LRLFEKYA  +GG+ NHRF L DA+M+KDNHIAA G+++ A+ + 
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  186  RKVIPFTTAIEVETESIDQVQAALEMDVDVIMLDNMPTELMKQAIALIRNHSHEVKIEAS  245
            R   PF   +EVE ES+   + A   +VD+IMLDNM+ E + QAI+LI  +S   +IE S
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECS  247

Query  246  GNITLDTIHKVAELGMDYISTSAMVTRSAWLDLSMN  281
            GNI + TI +   L++DY+S++++   +  LD+SM+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

128) nadC in NC_017454


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  187 bits (693),  Expect = 7e-49, Method: Compositional matrix adjust.
 Identities = 122/270 (46%), Positives = 187/270 (70%), Gaps = 2/270 (0%)

Query  4    LDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDPAIR  63
            +D  +  AL+ED+H+ D +T ++  +   A+  L+AKE+ VLAG+ V  RVF  +D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  64   FDA--RFPDGARVETGTLLAEMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAGT  121
            F+   +F DG R+ +G L+ E+ G    LL  ERVALN+LQ++ GIA++TA YVEA+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  122  GARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVLIKENHIAAAGGITEAVRRARA  181
              ++ DTRKT P LR+++K AVR+GGG NHR  L D++++K+NHIAA G++  A+ +ARA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  182  YIPHTMKIevetecleevaealeagaDIIMLDNMDLDAMRRAVGLIAGRALVEASGGVNL  241
            Y P    +EVE E L    EA  AG DIIMLDNM L+ + +A+ LIAGR+ +E SG +++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  242  ETVRGIAETGVDIISVGALTHSARAMDISM  271
             T+  +   ++D +S G+LTHSA+++D+SM
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

129) nadC in NC_002939


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  187 bits (693),  Expect = 7e-49, Method: Compositional matrix adjust.
 Identities = 122/270 (46%), Positives = 187/270 (70%), Gaps = 2/270 (0%)

Query  4    LDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDPAIR  63
            +D  +  AL+ED+H+ D +T ++  +   A+  L+AKE+ VLAG+ V  RVF  +D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  64   FDA--RFPDGARVETGTLLAEMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAGT  121
            F+   +F DG R+ +G L+ E+ G    LL  ERVALN+LQ++ GIA++TA YVEA+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  122  GARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVLIKENHIAAAGGITEAVRRARA  181
              ++ DTRKT P LR+++K AVR+GGG NHR  L D++++K+NHIAA G++  A+ +ARA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  182  YIPHTMKIevetecleevaealeagaDIIMLDNMDLDAMRRAVGLIAGRALVEASGGVNL  241
            Y P    +EVE E L    EA  AG DIIMLDNM L+ + +A+ LIAGR+ +E SG +++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  242  ETVRGIAETGVDIISVGALTHSARAMDISM  271
             T+  +   ++D +S G+LTHSA+++D+SM
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

130) Geob_2383 in NC_011979


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  186 bits (689),  Expect = 1e-48, Method: Compositional matrix adjust.
 Identities = 125/272 (46%), Positives = 189/272 (70%), Gaps = 2/272 (0%)

Query  2    IGLDRIIENALMEDIHTGDLTTQAVMRENRAMRATLKAKENLVLAGIKVAARVFHILDNS  61
            + +D  +  AL ED+H+ D +T+A+  ++   + +L AKE  VLAG+ V  RVF ++D  
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  62   IIFDA--HFADGSRIEKGATLAEISGDASFLLQGERVALNLLQRMCGVATQTAAYVEAVK  119
            + F+   +F DG R+  G  + EI G    LL  ERVALN+LQ++ G+A+ TAAYVEA+ 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  120  GTGARVVDTRKTTPGLRILEKYAVRIGGGINHRTGLYDGILIKENHIAAAGGITEAINRA  179
            +   +V DTRKTTP LR++EKYAVR+GGG NHR  L D+I++K+NHIAA G++  AI +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  180  RAYIPHTLKIevetenltevtealaaGADIIMLDNMDVVTMREAVAMIGGRALTEASGGV  239
            RAY P    +EVE E+L+   EA AAG DIIMLDNM +  + +A+++I+GR+  E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  240  NLSTVRQIAETGVDIISVGALTHSVRAMDISM  271
            +++T+ ++   ++D +S G+LTHS +++D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

131) Glov_1316 in NC_010814


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  186 bits (689),  Expect = 1e-48, Method: Compositional matrix adjust.
 Identities = 126/274 (46%), Positives = 192/274 (71%), Gaps = 6/274 (2%)

Query  3    LTLDDIIKNALREDIHTGDLTTQAVVPEPRPATARLVAKEPLTVAGMAVAARVFGLLDAS  62
            + +DD +K ALRED+H+ D +T+A+  +   A   L AKE+  +AG++V  RVF L+DA 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IVFE----FCCQDGQILEEGTVLARISGDASQLLQGERVALNLLQRMSGIATLTSSYVQA  118
            + F+    F  +DG+ L  G ++  I G    LL  ERVALN+LQ++SGIA++T++YV+A
Sbjct  71   VTFQNPHQF--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  119  VKGTGARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGILIKENHIAAAGGITEAIR  178
            + +   ++ DTRKTTP LR++EKYAVRVGGG NHR  L D+I++K+NHIAA G++  AI 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  179  RARAYIPHTLKieietetveqvqeALAAGADIIMLDNMDCETMRHCVGLINGQALVEASG  238
            +ARAY P    +E+E E++   +EA AAG DIIMLDNM  E + + + LI G++ +E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  239  GVNLTTVRAIAETGVDIISIGALTHSPRAMDISM  272
             +++TT+  +   ++D +S G+LTHS++++D+SM
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

132) nadC in NC_018664


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  186 bits (689),  Expect = 1e-48, Method: Compositional matrix adjust.
 Identities = 119/279 (43%), Positives = 192/279 (69%), Gaps = 2/279 (0%)

Query  2    LDKFLIEDIIKNALREDMNGGDITSDYLIDKLSIGKGIITSKEEGIICGLDIAELVFSTL  61
            L  F I+D +K ALRED+++ D +++ ++D  + +K  + +KE G++ GL + + VF+ +
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  62   DSTLTFTKLK--KDGDMVTKGEDIATIEGSLFSILKGERVALNFLQRMSGIASKSRIFAD  119
            D+ +TF +    KDGD +T G+ +  I GS+ S+L  ERVALNFLQ++SGIAS +  + +
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  120  RVKEYKVRVVDTRKTTPGLRVFEKYSVKIGGCFNHRHNLSDAVMIKDNHIIAAGGIKQAV  179
             + + +++V DTRKTTP LR+FEKY+V++GG +NHR NLSDA+M+KDNHI A G++++A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  180  EKLRKNIPHTTKIEVEVKNLEELQVALDLNTDIIMLDNMSIENMKKAVNITKGKAILEAS  239
             + R   P    +EVEV +L   + A     DIIMLDNMS+E++ +A+ +  G++ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  240  GNVTEENVIEIAKTGVDIISVGALTHSVKSLDISLNILN  278
            GN+    +  +   ++D +S G+LTHS KSLD+S++ L 
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

133) Gura_2818 in NC_009483


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  186 bits (688),  Expect = 2e-48, Method: Compositional matrix adjust.
 Identities = 126/270 (47%), Positives = 192/270 (72%), Gaps = 2/270 (0%)

Query  4    LDRIIENALMEDIHTGDITTLAVVRENRKMRARLKAKEAMMLAGIDVAARVFHVLDPGIT  63
            +D  +  AL ED+H+ D +T A+  ++ + +  L AKEA +LAG+ V  RVF ++D+ +T
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  64   FTA--HFSDGDLLNPGDIIAEIVGDASLLLQGERVALNLLQRMCGVATQTARYVQAVTGT  121
            F    +F DGD L +GD++ EI+G    LL  ERVALN+LQ++ G+A+ TA YV+A+ + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  122  NARVVDTRKTTPGLRMLEKYAVRVGGGINHRTGLYDGVLIKENHiaaaggitaaisrara  181
              +V DTRKTTP LR++EKYAVRVGGG NHR  L D++++K+NHIAA G++  AI++ARA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  182  YIPHTLKIEVETETLAEVGEALTAGADIIMLDNMDVTTMREAVAMIGGKALAEASGGVNL  241
            Y P    +EVE E+LA   EA +AG DIIMLDNM +  + +A+++I+G++  E SG +++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  242  TTVREIAETGVDIISVGALTHSVRAMDISM  271
            TT+  +   ++D +S G+LTHS +++D+SM
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

134) Pse7367_2252 in NC_019701


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  186 bits (691),  Expect = 9e-49, Method: Compositional matrix adjust.
 Identities = 130/281 (47%), Positives = 186/281 (67%), Gaps = 7/281 (2%)

Query  2    LPPFVVLDPIISAWLREDIGRGDRTTDCLFANGSPVGRAEIVAKEAGVIAGLPIAKRSFY  61
            L PF + D  + A LRED+   D +T+ +F + +  ++  + AKEAGV+AGL + +R F 
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFT  65

Query  62   LLDPEVEFK--QLVEDGTECEKGQKIATIAGSLSSLLTGERVALNILMQLSGISSLTREY  119
            L+D+EV F+  +   DG     G+ +  I GS+ SLLT ERVALN+L +LSGI+S+T  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  120  GLAIADLPTQLVDTRKTTPGLRLFEKYATQVGGAINHRLGLDDAVMIKDNHIIAAGGITK  179
              A++D   ++ DTRKTTP LRLFEKYA +VGG+ NHR+ L DA+M+KDNHI A G++ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  180  AVQQIRAQMPFTTTIEVETENIDQVKEALLQRVDIIMLDNMSAELMSEAIALIRSQDPKV  239
            A+ Q RA  PF   +EVE E++    EA    VDIIMLDNMS E + +AI+LI     + 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  240  KIEASGNITIVTIRSVAELEVDYISTSAMVARSRWLDLSMN  280
            +IE SGNI + TI     L +DY+S++++   ++ LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

135) MROS_0953 in NC_018178


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  186 bits (691),  Expect = 9e-49, Method: Compositional matrix adjust.
 Identities = 119/271 (44%), Positives = 188/271 (70%), Gaps = 2/271 (0%)

Query  9    VDRLIQTALNEDIGKGDVTTNAIIPPHQKGTAAIYAKESGVIAGLFVAKDVFKKLDGNSK  68
            +D  +++AL ED+   D +TNAI+  H ++  +++AKE+GV+AGL V + VF  +D++  
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  69   WKN--LVAEGEEVKKGQKVAEVTGNLRALLSGERTALNFLQRISGIATAARKFIETVADT  126
             +N     +G+ +  G+ V E+ G++R+LL+ ER ALNFLQ++SGIA+ +  ++E+++D 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  127  NVKILDTRKTVPGLRLLDKYGVYAGGGTNHRFGLYDMALIKDNHIEAAGGIKNAVNrvrk  186
             +K++DTRKT P LRL++KY+V  GGG NHRF L D  ++KDNHI A G++++A+ + R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  187  kygkkykveveTTNLMEVREALDAGADIIMLDNMTISQMKKAVKLINGKCKTEASGNVDL  246
                   VEVE  +L    EA  AG DIIMLDNM++ Q+ +A+ LI G+ + E SGN+D+
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  247  KRIKKIATAGVDFISVGSLTHSVKALDLSMK  277
              I ++   ++D++S GSLTHS K+LD+SMK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

136) nadC in NC_017068


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  184 bits (683),  Expect = 4e-48, Method: Compositional matrix adjust.
 Identities = 124/275 (46%), Positives = 193/275 (71%), Gaps = 8/275 (2%)

Query  4    LGLDEKIKGWLQEDVGSGDITTLATVPKAAVTHAIIHAKDTGILAGVDVAERVFALLDPD  63
            + +D+ +K+ L+EDV S D +T A     + +   + AK++G+LAG+ V +RVF+L+D++
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  64   VKFNKV--LEDGAELTPTSVIATLDGSAQAILTGERLALNLLQHLSGVATRTHKLAAIAA  121
            V F++   + DG  LT+  ++  + GS +++LT ER+ALN+LQHLSG+A+ T   AA   
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT---AAYVE  127

Query  122  PYGA---RLVDTRKTTPGLRLLDKYAVKVGGGANHRLGLYDAILIKDNHIQVAGGITAAL  178
            + G    ++ DTRKTTP LRL++KYAV+VGGG NHR+ L DAI++KDNHI   G++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  ERAKAYASHMTKIEIEVEDLTGVEEALAGKADVIMLDNMAPELMTEAVKLIDHRAVVEAS  238
             +A+AYA+ +  +E+EVE L++ EEA A+  D+IMLDNM+ E + +A+ LI  R+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGIDETTLAAAAKSGVDVISVGALTHSVKALDISM  273
            G ID TT++     ++D +S G+LTHS K+LD+SM
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

137) nadC in NC_012491


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  184 bits (681),  Expect = 6e-48, Method: Compositional matrix adjust.
 Identities = 125/262 (48%), Positives = 189/262 (73%), Gaps = 2/262 (0%)

Query  16   LQEDVGFGDVTTMSTIPESEQGVGILYAKEAGIVAGLPIAEQVFATVDSTLVFEA--KVE  73
            L+EDV   D +T + + +  Q+   L+AKEAG++AGL + ++VF+  D+ + F+   +  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  74   EGARVEVGQQIAEVSGSVRSILSGERLALNLMQRLSGIATKTSEYATAVAGTKARVVDTR  133
            +G R+  G+ + E+ GSVRS+L+ ER+ALN++Q+LSGIA+ T+ Y  A+++ + +V DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  134  KTTPGLRALEKYAVRVGGGYNHRFALYDAVMIKDNHIKgaggiaqavaaaraviPHTMTV  193
            KTTP LR +EKYAVRVGGGYNHRF L DA+M+KDNHI + G++ +A+A ARA  P    V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  194  EVEAESFEQVQEALAAGADTIMLDNMSLDQMVEAVQFINGRAVVEASGGVSLETIGDIAK  253
            EVE ES+   +EA AAG D IMLDNMSL+Q+ +A+ +I GR+ +E SG + + TI+ +  
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  254  TGVDIISVGALTHSVKAFDISL  275
             ++D +S G+LTHS K++D+S+
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSM  282

138) NadC in NC_009454


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  183 bits (679),  Expect = 8e-48, Method: Compositional matrix adjust.
 Identities = 131/276 (48%), Positives = 195/276 (71%), Gaps = 2/276 (0%)

Query  2    ELNQIELNRLIERCLREDIGTGDLTTNSIVPPDAVSGGYILAKEDGVVAGLPVAEGVFLR  61
            +L  ++++  +   LRED+ + D +TN+I   ++ +   ++AKE GV+AGL V + VF  
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   LDPFVEFRA--LVRDGERIKSGQVLAELTGRARAILTGERLALNFLQRLSGIATRTARLV  119
            +D+ V F+     +DG+R+ SG+++ E+ G  R++LT ER+ALNFLQ+LSGIA+ TA  V
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  ELIAGEKARLVDTRKTTPGLRMLEKYAVRVGGGYNHRFGLYDAVLIKDNHIKaaggiraa  179
            E +++++ ++ DTRKTTP LR++EKYAVRVGGGYNHRF L DA+++KDNHI A G+++ A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  veaarrgaPHTARIEVEVEDLAGVEEALQAGADIIMLDNMDPAAMKEAVALINGRALVEA  239
            +  AR  AP    +EVEVE LA+ EEA  AG DIIMLDNM    + +A++LI GR+ +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  240  SGRISEENIRAVAAAGVDLISAGALTHSVKSLDISL  275
            SG I    I    + ++D +S+G+LTHS KSLD+S+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

139) Desgi_0291 in NC_021184


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  183 bits (680),  Expect = 8e-48, Method: Compositional matrix adjust.
 Identities = 122/272 (45%), Positives = 190/272 (70%), Gaps = 6/272 (2%)

Query  8    LNEIIDRALAEDIGPGDLTTNSIV--PGDINVVGYIKAKQNGVIAGLSVARAVFRRLDAD  65
            +++ +  AL ED+ + D +TN+I    G+ +V  +  AK+ GV+AGL+V + VF  +DA+
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLF--AKEAGVLAGLTVFQRVFTLFDAE  70

Query  66   LQYI--PLVAEGARVSAGDVLVQLNGRARTVLTGERLALNFLQRLSGIATVTAGLVEMVR  123
            + +       +G R+++GD+++++ G  R++LT ER+ALNFLQ+LSGIA++TA+ VE + 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  124  DYPVRIVDTRKTTPGLRQLEKHAVRVGGGHNHRLGLFDAVLIKDNHIRVAGGIKQAVERA  183
            D  +++ DTRKTTP LR +EK AVRVGGG NHR+ L DA+++KDNHI   G++++A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  184  RSQVPHTTKIEVETEDLEGVREALAAGADIIMLDNMDPSTMAQAVGLVSGRAIVEASGGI  243
            R+  P    +EVE E L +  EA AAG DIIMLDNM    + QA+ L++GR+ +E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  244  SVDTIQSVAATGVDIISVGALTHSAAALDISL  275
             + TI    + ++D +S G+LTHSA +LD+S+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

140) Rpdx1_1218 in NC_014834


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  182 bits (676),  Expect = 2e-47, Method: Compositional matrix adjust.
 Identities = 115/277 (42%), Positives = 191/277 (69%), Gaps = 4/277 (1%)

Query  13   LSPLAITDAVRRALDEDLGRAGDVTSVATIPEATKAHAILVARQGGVIAGLPLAVETFRQ  72
            L+P+ I D+++ AL ED+ ++ D ++ A + +  +A   L A+++GV+AGL +    F  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  73   LSADVAITA--HVRDGDTVATGIQVLTISGPARAVLTGERTALNFVGRLSGIATLTADYV  130
            + A+V++    + +DGD +++G  VL I G+ R++LT ER ALNF+ +LSGIA++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  131  RHTAGSKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGGIRPV  190
               ++ ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  G+++  
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  191  LEAARSKIGHLVKIEIEVDTLDQLREVLDTGLADVVLLDNMDLDTLKQAVAMSAGRVVLE  250
            +  AR+    +  +E+EV++L    E   +G+ D+++LDNM L+ + QA+++ AGR  +E
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  251  ASGGVTRESISRIAATGVDYASSGALTHSAPNFDVAL  287
             SG +   +ISR+ + ++DY SSG+LTHSA ++D ++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

141) Halsa_0362 in NC_014654


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  182 bits (674),  Expect = 2e-47, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 188/275 (69%), Gaps = 2/275 (0%)

Query  3    LNKFILADIIDRAIKEDLGYGDITTDNLIAEDAQSKALITIKEAGVAAGLEIARSVFNKY  62
            L  F + D +  A++ED+   D +T+ ++ +++Q+K  +  KEAGV AGL + + VF  +
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DPDLKFKA--LLTEGDKLDAGTVLAEVEGSTRSILKAERLALNFLQRLSGIATKSREYVE  120
            D+++ F+    + +GD+L +G ++ E+ GS RS+L  ER+ALNFLQ+LSGIA+ +  YVE
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  121  LVEAYPAQIVDTRKTTPTLRMLEKYAVKVGGAKNHRMGLDDCVMIKDNHLKAAGSIKNAV  180
             +     ++ DTRKTTP LR++EKYAV+VGG+ NHR  L D +M+KDNH+ A GS+++A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  181  EKIKANISHTTKIELEIDELPQLDEALEAEVDIILLDNMSPEELKKAVQIVDGRVILEAS  240
             + +A  +    +E+E++ L+  +EA  A VDII+LDNMS E++ +A+ ++ GR  +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  241  GGITKENVAEIAASGVDIISVGALTHQINSIDIAL  275
            G I    ++ + + ++D +S G+LTH  +S+D+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

142) RPC_4340 in NC_007925


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  182 bits (674),  Expect = 3e-47, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 192/278 (70%), Gaps = 4/278 (1%)

Query  14   LSPFAIAEAVRRALEEDLGRAGDITSNATIPAEAHAQATMVARQAGTIAGLPLAVAAFQA  73
            L+PF I ++++ AL ED+ ++ D ++NA +  +++A+ ++ A++AG +AGL +    F  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  74   LSPDI-FIQPH-VHDGDPVARGIPVLTISGPARAVLAGERTALNFVGRLSGIATLTADYV  131
            + +++ F +PH   DGD ++ G  VL I G+ R++L+ ER ALNF+ +LSGIA++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  132  RHAAGSKLRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGGVRPV  191
               ++ ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  G+V+  
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  192  LERARARIGHLVKVEIEVDTLDQLKEVLASGLADVVLLDNMDIATLQEAVRLADGRVVLE  251
            + +ARA    +  VE+EV++L    E  A+G+ D+++LDNM +  +++A+ L  GR  +E
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  252  VSGGVTQDTVAAIAATGVDYASAGALTHSAPNFDVALD  289
             SG +   T++ + + ++DY S+G+LTHSA ++D ++ 
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

143) Acfer_0928 in NC_013740


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  181 bits (671),  Expect = 4e-47, Method: Compositional matrix adjust.
 Identities = 124/271 (46%), Positives = 188/271 (70%), Gaps = 4/271 (1%)

Query  6    LDKQLEEWLAEDVGSGDLTSEALLPAEAVTCGIIHAKDTGILCGVEVARRVFQVLDPGLT  65
            +D  L   L EDV S D +++A++  ++ +   + AK++G+L G+ V +RVF ++D+ +T
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   FEA--LARDGEPLEPGTLIAKITGSARSVLTGERLALNLLQHLSGIATRTRKLAD-LARP  122
            F+     +DG+ L +G L+  I GS RS+LT ER+ALN+LQHLSGIA+ T    + L+  
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  123  YGTRVVDTRKTTPGLRLLEKYAVRTGGGHNHRLGLYDAILIKDNHIAVSGGVKEALARAK  182
               +V DTRKTTP LRL+EKYAVR GGG NHR+ L DAI++KDNHIA  G+V+ A+A+A+
Sbjct  133  -RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  183  AYASHMTKIEIEVESLEQAREAVEGGADVIMLDNMAPDAMKECVDMISHRAVVEASGGID  242
            AYA+ +  +E+EVESL  A EA  +G D+IMLDNM+ + + + + +I+ R+ +E SG ID
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  243  EHNLEAAAAAGVDVISIGALTHSVKALDISL  273
               +    + ++D +S G+LTHS K+LD+S+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

144) nadC in NC_010337


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  181 bits (672),  Expect = 4e-47, Method: Compositional matrix adjust.
 Identities = 119/271 (44%), Positives = 187/271 (70%), Gaps = 2/271 (0%)

Query  7    EVREVVLRALREDIGQGDLTTMSLVPADAQTKGIIHAKEAGVIAGMPVARIVFETVDPGL  66
            ++ + +  ALRED+   D +T ++   ++Q+K  + AKEAGV+AG+ V + VF   D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  67   IFEA--KVKDGERIDKGTVLAEVRGSARSILIGERLALNFLQRLSGIATKTARCVEQVTY  124
             F+   + KDG+R+  G ++ E+ GS RS+L  ER+ALNFLQ+LSGIA+ TA  VE +  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  125  YQARIVDTRKTTPGLRMLEKYAVRMGGGKNHRFGLFDGVLIKDNHIRVAGGIHQAVSQVR  184
             + ++ DTRKTTP LR++EKYAVR+GGG NHRF L D++++KDNHI   G++++A++Q R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  185  QAVPHTVKIEVEVEDLAGVVEALEANADIIMLDNMAPELMKEAVRMIGSRALVEASGGVS  244
               P    +EVEVE LA+  EA  A  DIIMLDNM+ E + +A+ +I++R+ +E SG + 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  245  EEALVEIAKTGVHLISIGALTHSVKALDISL  275
              ++  +   +++ +S G+LTHS K+LD+S+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

145) nadC in NC_005125


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  181 bits (669),  Expect = 6e-47, Method: Compositional matrix adjust.
 Identities = 121/265 (46%), Positives = 187/265 (71%), Gaps = 7/265 (2%)

Query  22   LAEDWGRGDRTSEALFAEESPDGHGKILL--KEAGVVAGLPLVERLFAIVDPAVRF--AP  77
            L ED    D +++A+F ++   G++K+ L  KEAGV+AGL + +R+F++ D+ V F  + 
Sbjct  21   LREDVHSEDYSTNAIFDHH---GQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPH  77

Query  78   MCEEGTAAEARTVIAVVEGPVRSLLMGERVALNLLQRLSGIATITRRYVERLAGHHARLV  137
               +G    +  ++  + G+VRSLL  ERVALN+LQ+LSGIA++T  YVE L++++ ++ 
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  138  DTRKTTPGLRLIEKYAVRVGGALNHRFGLDDAAMIKDNHIEAAGGIRPAVERLRGRIPFL  197
            DTRKTTP LRL+EKYAVRVGG+ NHRF L DA M+KDNHI A G+++ A+ + R+  PF+
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  198  MPIEVETESLEQVQEALGCGVQVIMLDNMPVERMREAVQLIAGRVLTEASGNITLDTLGD  257
              +EVE ESL   +EA + GV++IMLDNM++E++ +A+ LIAGR   E SGNI + T++ 
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISR  257

Query  258  VAATGVDYISTSATITRAPWLDISL  282
              + ++DY+S+++    A  LD+S+
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFSM  282

146) RoseRS_0439 in NC_009523


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  180 bits (666),  Expect = 1e-46, Method: Compositional matrix adjust.
 Identities = 116/261 (45%), Positives = 181/261 (70%), Gaps = 3/261 (1%)

Query  13   DAIRRALAEDVGTGDVTTNSIVPPDATMRGRIVAKQEGIVAGLDVAHAVYRMVDERVVFT  72
            D+++ AL EDV + D +TN+I   ++  +  + AK+ G++AGL V + V+ + D  V F 
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  73   T--DVAEGARVARGQTLALVSGPARALLTAERVALNFLGRMSGIATLTRRFVDAVAGTRA  130
               +  +G R++ G+ +  + G+ R+LLT ERVALNFL ++SGIA++T  +V+A+++ R 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  131  VILDTRKTAPGLRMVDKLAVRRGGGRNHRIGLYDMVLIKDNHIDFAGSLRAAVERARAHA  190
             ++DTRKT+P LR+ +K AVR GGG NHR+ L D +++KDNHI   GS++ A+ +ARA A
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  191  PHLG-IEVEARSLADVREALDLGVQRIMLDNMSLDAMAEAVRLVAGRARLEASGNVSLET  249
            P +  +EVE  SLA   EA   GV+ IMLDNMSL+ + +A+ L+AGR+R+E SGN+ + T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  250  VRRIAETGVDDISIGALTHSA  270
            + R+   ++D +S G+LTHSA
Sbjct  255  ISRFRGLAIDYVSSGSLTHSA  275

147) Dtur_0752 in NC_011661


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  180 bits (668),  Expect = 6e-47, Method: Compositional matrix adjust.
 Identities = 120/277 (44%), Positives = 189/277 (69%), Gaps = 5/277 (1%)

Query  3    LIPYLHLRKIVEEALKEDIGFGDITTESTIPEDMISRAVIIAKEEGILAGLPVAEEVFKL  62
            L P+ ++   +  AL+ED+   D +T++ + ++  ++  ++AKE G+LAGL V + VF L
Sbjct  8    LTPF-QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  63   LDSKIEFK---EFKKDGDEIKKGDVILEIKGKTKTILMGERTALNFLQRLSGIATYTKKC  119
            +D+ + F+   +FK DGD +  GD++LEI G  +++L  ER ALNFLQ+LSGIA+ T   
Sbjct  67   FDAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  120  VDVVKPYGVKILDTRKTTPTLRIFEKYAVKIGGGENHRFGLYDMVLIKDNHIRAVGSIKE  179
            V+ +    +K++DTRKTTP LR+FEKYAV++GGG NHRF L D +++KDNHI AVGS++ 
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  180  AIERVRERVSHVYKIEVEVTNleelkealeskaDIVLLDNMDYDTLKEAVSIAKGKVMIE  239
            AI + R   + V  +EVEV +L    EA  +  DI++LDNM  + + +A+++  G+  IE
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  240  VSGNISLEDLEKIARLGVNFISIGKLTHSYKSLDLSL  276
             SGNI +  + ++  L+++++S G LTHS KSLD+S+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

148) nadC in NC_004463


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  180 bits (668),  Expect = 7e-47, Method: Compositional matrix adjust.
 Identities = 111/277 (41%), Positives = 190/277 (69%), Gaps = 4/277 (1%)

Query  14   LSPLAIDESVHRALDEDLGRAGDITSLATIPEATKAKAILVARQSGVIAGLPLALATLQE  73
            L+P+ ID+++  AL ED+ ++ D ++ A + +  +AK  L A+++GV+AGL +    +  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  74   LSSDIEVRA--HVRDAARMARGQHVLTISGPARAILTAERTALNFVGRLSGVATLTADYV  131
            + +++  +   + +D+ R++ G+ VL I G+ R++LT ER ALNF+ +LSG+A++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  132  ARTEGSRMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGGIRPV  191
                + R+++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  G+++  
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  192  LERARAHAGHLIKIEIEVDTLAQLREVLDTGMADAVLLDNMDLATLREAVRMSEGRLKLE  251
            + +ARA A  +  +E+EV++LA   E   +G+ D ++LDNM L  + +A+ +  GR ++E
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  252  ASGGVTLDSIAAIAATGVDYASSGALTHSAPNFDCAL  288
             SG + + +I+ + + ++DY SSG+LTHSA ++D ++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

149) nadC in NC_021499


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  179 bits (664),  Expect = 1e-46, Method: Compositional matrix adjust.
 Identities = 119/278 (43%), Positives = 200/278 (72%), Gaps = 5/278 (1%)

Query  7    ADLTT-EIEANVRTALKEDIGSGDITAQLIPETR-QARASVITREAAIISGCAWVNEVFR  64
            +DLT  +I+  +++AL+ED+ S D +++ I + + QA+ S++++EA++++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVQVQ--WQVQDGQRAEANQVLFHLEGPARALLSGERSALNFLQCLSGVATRVGHY  122
             +D+ V  Q   Q +DG+R  + ++++++ G+ R+LL+ ER ALNFLQ LSG+A+  + Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  VDLVKDTQVKLLDTRKTLPGLRLAQKYAVTCGGGHNHRIGLYDAFLIKENHIAASGGIAQ  182
            V+ + D ++K++DTRKT P LRL +KYAV  GGG NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AIEAAHRIAP-GKPVEVEVESLDELQQALDAGADIIMLDELSLDDMRTAVRLTNGRAKLE  241
            AI  A+  AP  K VEVEVESL   ++A  AG DIIMLD++SL+++  A+ L  GR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRTIADTGVDYISIGTLTKDVKAIDLSMR  279
             SG ++ TT+  + + ++DY+S G+LT   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

150) nadC in NC_014019


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  179 bits (663),  Expect = 2e-46, Method: Compositional matrix adjust.
 Identities = 124/281 (45%), Positives = 192/281 (69%), Gaps = 6/281 (2%)

Query  1    MNTLKLQKLLQSFFIEDIGDGDITCEAIFSPSDQGKAVFTAKQSGIIAGVELIKEGFHLI  60
            +  ++++  L++ + ED+   D + +AIF   +Q+K  + AK++G++AG+ +++  F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DPDVKVNFEK----KDGDVLKPGDKIATVSGPVRSILTGERVILNLLQRMSGIATMTHKA  116
            D++V   F++    KDGD L +GD +  + G+VRS+LT ERV LN+LQ++SGIA+MT   
Sbjct  68   DAEV--TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  117  VALLGSSHTRICDTRKTTPGMRMLEKYAVRAGGGYNHRFGLYDGVMLKDNHIAHAGSILD  176
            V  LG  + ++ DTRKTTP +R++EKYAVR GGGYNHRF L D++MLKDNHIA  GS+  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  177  AVVKVREQVGHMVKVEVEIENKSQLLEAIEAGADVIMFDNCSPEVIKDWIPLVPAHIVTE  236
            A+ + R     +  VEVE+E+ +   EA  AG D+IM+DN S E I + I L++++   E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  237  ASGGITLGTLHSFRDSGVDYISLGALTHSAGSIDISLDLLT  277
             SG I + T+  FR+ ++DY+S G+LTHSA S+D+S+  LT
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

151) AciX8_1439 in NC_016631


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  179 bits (664),  Expect = 2e-46, Method: Compositional matrix adjust.
 Identities = 120/277 (44%), Positives = 192/277 (70%), Gaps = 11/277 (3%)

Query  8    IDQAVRAALAEDAPWGDLTSQTFIPESAIASALLAAREPGVCCGAQVFTTVMGLTDARIS  67
            ID++++AAL ED    D ++++++ + + A   L A+E+GV  G  VF  V  L DA ++
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   TVFHA----EEGERFDTGDTVATVIGPARSVLQAERVALNFMQRMSGIATLTAKYVAEIA  123
              F+      +G+R+ +GD V  +IG+ RS+L  ERVALNF+Q++SGIA++TA YV  ++
Sbjct  73   --FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  124  GTRARIVDTRKTTPGLRVLERYAVRCGGGMNHRFSLSDAVMVKDNHLAVLTASSKLGVTE  183
            + R ++ DTRKTTP LR++E+YAVR GGG NHRF+LSDA+M+KDNH+A + +  K     
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK-----  185

Query  184  ALREARSRLPHTVHFEVEVDRIDQIEPVLAAGVDTIMLDNFTLEELRQGVALVAGRALVE  243
            A+ +AR+  P     EVEV+ +   E   AAGVD IMLDN +LE++ Q+++L+AGR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  244  ASGSVRLETVGDIARTGVDIISVGALTHSVRALDLGL  280
             SG++ + T++ +   ++D +S G+LTHS ++LD+++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

152) PGN_0534 in NC_010729


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  178 bits (660),  Expect = 3e-46, Method: Compositional matrix adjust.
 Identities = 122/264 (47%), Positives = 176/264 (67%), Gaps = 3/264 (1%)

Query  15   AIAEDIADGDISSNAIIPQSEGAAATMVMKADGIISGMEVARRVFERFEA-VTW-TPY-V  71
            A+ ED+   D S+NAI+ +   A  ++  K  G+++G+ V +RVF  F+A VT   P   
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  72   SDGDSVKRGQVILRVEGSYRALLQAERLALNFLQRMSGIATMTARYAEALKGTAVRLLDT  131
             DGD +  G+++L + GS R+LL  ER+ALNFLQ++SGIA+MTA Y EAL +  ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  132  RKTAPGMRITDKMAVRHGGGHNHRMGLYDMIMLKDNHIKVAGGIPQAIEAARRALPLSIK  191
            RKT+P +R+ +K AVR GGG NHR  L D IMLKDNHI   G++ +AI  AR   P+   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  192  LEVETSNLAEVEEAVRYGADIIMLDNMDNDTMCEAVRLIAGRARTEASGNMTLERLQSVA  251
            +EVE  +LA  EEA   G DIIMLDNM  + + +A+ LIAGR+R E SGN+ +  +    
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  252  ETGVDYISVGALTHSVTAMDISMN  275
              ++DY+S G+LTHS  ++D+SM+
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

153) Halha_1152 in NC_019978


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  178 bits (660),  Expect = 3e-46, Method: Compositional matrix adjust.
 Identities = 121/264 (46%), Positives = 178/264 (68%), Gaps = 2/264 (0%)

Query  14   EALAEDIGTGDLTTQSTIKDNKLETGIILAKENGVIAGLEVAKLVFDCLDNDIKFEK--L  71
             AL ED+ + D +T++ + ++      ++AKE GV+AGL V + VF  +D ++ F++   
Sbjct  19   AALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  72   VTEGSKVKRQTPVVKVSGPIASLLSGERLALNFLQRMSGIATKTARYVELVADYDVRIVD  131
              +G ++     V+ + G++ SLL+ ER+ALNFLQ++SGIA+ TA YVE ++D  +++ D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  132  TRKTTPNLRSLEKYAVRIGGGFNHRSGLYDAVMIKDNHIQAVGSITKAVKRARENVAHTV  191
            TRKTTPNLR +EKYAVR+GGG+NHR  L DA+M+KDNHI AVGS+ KA+ +AR   +   
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  192  KIEVETEDLAQVKEALSVGVDIIMLDNMSSQLMAQAVELIGEQAIVEASGGITAETIREV  251
             +EVE E LA   EA + GVDIIMLDNMS + + QA+ LI+ ++ +E SG I   TI   
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  252  AQTGADVISVGELTHTIDSLDISL  275
               + D +S G LTH+  SLD+S+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

154) nadC in NC_005296


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  178 bits (660),  Expect = 3e-46, Method: Compositional matrix adjust.
 Identities = 114/277 (42%), Positives = 190/277 (69%), Gaps = 4/277 (1%)

Query  13   LSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVIAGLPLAIETFRQ  72
            L+P+ I D+++ AL ED+ ++ D ++ A + +  QA   L A++AGV+AGL +    F  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  73   LSTDVAITA--HARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLSGIATLTADYV  130
            + ++V++    + +DGD +++G  VL I G+ R++LT ER ALNF+ +LSGIA++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  131  RHTAGTKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGGIRPV  190
               ++ ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  G+++  
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  191  LEAARAKIGHLVKIEIEVDTIDQLREVLDTNLADVVLLDNMDLDTLKKAVAMSAGRVVLE  250
            +  ARA    +  +E+EV+++    E   + + D+++LDNM L+ + +A+++ AGR  +E
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  251  ASGGVTRESISRIAATGVDYASSGALTHSAPNFDVAL  287
             SG +   +ISR+ + ++DY SSG+LTHSA ++D ++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

155) nadC in NC_011983


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  178 bits (658),  Expect = 4e-46, Method: Compositional matrix adjust.
 Identities = 116/283 (41%), Positives = 193/283 (69%), Gaps = 5/283 (1%)

Query  1    MTLVS--LPRLIVEPLVRNALLEDLGLAGDVTSAAVIPEDHRSTVAMVARQPGVVAGLDA  58
            M+++S  L  + ++  ++ AL ED+  + D ++ A++ ++ ++ V++ A+++GV+AGL  
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  59   SELAFQLVDPSIVM--TRHVHDGAKVAAGDVIATIEGPSRGLLTAERTALNFLGHLSGIA  116
             +  F L D+ +     ++  DG ++++GD++  I G+ R+LLT ER ALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  117  SVTAGIVEAINGTKASIVCTRKTTPGLRALEKYAVRAGGGMNHRFALHDAVLIKDNHVAI  176
            S+TA+ VEA+ + +  +  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNH+A 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  177  AGGVAEAIRRAKAGVGHMVKIEVEVDTLDQLRDAMEEGVDAVLLDNMTPDQLRDAVGIVA  236
             G+V  AI +A+A    +  +EVEV++L    +A   GVD ++LDNM+ +Q+ +A+ ++A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  237  GRAITEASGRitpataaaiaaSGVDLISVGWLTHSAPTLDIGL  279
            GR+  E SG I  +T + + + ++D +S G LTHSA +LD+++
Sbjct  240  GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

156) nadC in NC_014103


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (657),  Expect = 5e-46, Method: Compositional matrix adjust.
 Identities = 125/281 (45%), Positives = 191/281 (68%), Gaps = 6/281 (2%)

Query  1    MNTLKLQKLLQSFFIEDIGDGDITCEAIFSPSDQGKAVFTAKQSGIIAGVELIKEGFHLI  60
            +  ++++  L++ + ED+   D + +AIF   +Q+K  + AK++G++AG+ +++  F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DPNVKVNFEK----KDGDVLKPGDKIATVSGSVRSILTGERVILNLLQRMSGIATMTHKA  116
            D++V   F++    KDGD L +GD +  + GSVRS+LT ERV LN+LQ++SGIA+MT   
Sbjct  68   DAEV--TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  117  VALLGSSHTRICDTRKTTPGMRMLEKYAVRAGGGYNHRFGLYDGVMLKDNHIAHAGSILD  176
            V  LG  + ++ DTRKTTP +R++EKYAVR GGGYNHRF L D++MLKDNHIA  GS+  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  177  AVVKVREQVGHMVKVEVEIENKSQLLEAIEAGADVIMFDNCSPEVIKGWIPLVPAHIVTE  236
            A+ + R     +  VEVE+E+ +   EA  AG D+IM+DN S E I   I L++++   E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  237  ASGGITLGTLHSFRDSGVDYISLGALTHSAGSIDISLDLLT  277
             SG I + T+  FR+ ++DY+S G+LTHSA S+D+S+  LT
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

157) SYN_02885 in NC_007759


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (656),  Expect = 5e-46, Method: Compositional matrix adjust.
 Identities = 114/264 (44%), Positives = 188/264 (72%), Gaps = 2/264 (0%)

Query  16   SALEEDVGSGDVTTAAVLSGEENGYARVVAKSELVVAGIDIFRQVFFAVDDRIAIAVCQQ  75
            +AL EDV S D +T A++  + ++   + AK   V+AG+ +F++VF   D  +++   +Q
Sbjct  19   AALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  76   --DSQQARKGQVVAEITGSLAGILIAERVALNFFQRMCGIATATRQYVEAVAGTKAKILD  133
              D+++   G++V EI GS+ ++L  ERVALNF+Q++ GIA+ T  YVEA+++ + K++D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  134  TRKTAPGLRILDKYAVRIGGGANHRFGLSNAVLIKDNHIEAAGGIGTAVARVRQRASHTL  193
            TRKT+P LR+++KYAVR+GGG NHRF LS+A+++KDNHI A G++  A+A+ R  A+   
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  194  KIEVEVKNFQELNEAIQAGVDIIMLDNMSVPDMREAVLHVNGRIPLEASGNVTLATVRQI  253
             +EVEV ++   +EA  AGVDIIMLDNMS+ ++ +A+  + GR  +E SGN+ ++T+ ++
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  254  AETGVDFISVGALTHSVKAADLSL  277
               ++D++S G+LTHS K+ D+S+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

158) UWK_00179 in NC_020304


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (656),  Expect = 6e-46, Method: Compositional matrix adjust.
 Identities = 122/267 (46%), Positives = 189/267 (71%), Gaps = 3/267 (1%)

Query  10   LRSFLREDIGNGDLSSEPLFGKDEQGCARLVARESFVAAGVDSVAAQVFSLQNPEI--QC  67
            L++ LRED+ + D S++++F+ + Q+   L A+E+ V AG+ +V  +VF+L ++E+  Q 
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGL-TVFQRVFTLFDAEVTFQN  75

Query  68   TGAVNDGRVVSPGDILLMVSGPVVDLLKAERVALNLLQRLSGIATLTARFVEKTKLFPVR  127
                +DG  +++GD++L + G+V  LL  ERVALN+LQ+LSGIA++TA +VE      ++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  128  ITDTRKTTPGLRMLEKYAVRVGGGYNHRFNLSDGVLIKDNHIAARGSLTQAVQILREKVP  187
            + DTRKTTP LR++EKYAVRVGGGYNHRFNLSD++++KDNHIAA GS+ +A+   R   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  188  HTIKIEVETDTLDQVRECLECHADIIMLDNMDLETMKQAVAMIDGRALVEASGGVNLDTV  247
                +EVE ++L    E      DIIMLDNM LE + QA+++I GR+ +E SG +++ T+
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  248  AGIAATGVDIISVGALTHSAPSCDIGM  274
            + + + ++D +S G+LTHSA S D++M
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

159) C624_06120 in NC_021351


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (656),  Expect = 6e-46, Method: Compositional matrix adjust.
 Identities = 112/275 (41%), Positives = 192/275 (70%), Gaps = 6/275 (2%)

Query  4    HIDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            +ID  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSRYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++S   +I++A 
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-  190

Query  182  LNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVNLIGGRALVEAS  241
               +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  191  ---RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTVGKIASTGVDVISVGALTHSVRALDLGL  276
            G +++ T++++ + ++D +S G+LTHS ++LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

160) C629_06120 in NC_021352


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (656),  Expect = 6e-46, Method: Compositional matrix adjust.
 Identities = 112/275 (41%), Positives = 192/275 (70%), Gaps = 6/275 (2%)

Query  4    HIDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            +ID  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSRYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++S   +I++A 
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-  190

Query  182  LNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVNLIGGRALVEAS  241
               +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  191  ---RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTVGKIASTGVDVISVGALTHSVRALDLGL  276
            G +++ T++++ + ++D +S G+LTHS ++LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

161) Desaci_1883 in NC_018068


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (655),  Expect = 7e-46, Method: Compositional matrix adjust.
 Identities = 126/276 (46%), Positives = 193/276 (70%), Gaps = 2/276 (0%)

Query  1    MNPLYFHNIVNEALKEDLGFQDLTTEAIISENHCSVAEITAKEAGIIAGMDVANYAFKLL  60
            + P+ +++ ++ AL+ED+  +D +T+AI+ ++  +   + AKEAG++AG+ V +  F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DDTVSFQA--KIVDGEKVSSGQVVAVIEGRTRTLLGGERVALNFMQRLSGIATGTKKAVE  118
            D  V+FQ   ++ DG++++SG++V  I G  R+LL  ERVALNF+Q+LSGIA+ T   VE
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  SIKDFPCRLVDTRKTTPGLRGLEKYAVRMGGGYNHRFGLFDAILIKDNHIAAAGGITEAV  178
            ++ D   ++ DTRKTTP LR +EKYAVR+GGGYNHRF L DAI++KDNHIAA G++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  SLVREKIGHMVKVEVETETLAQVEEALSVPIDIIMLDNMSLNQMREAVRLINKKVLAEAS  238
            +  R     +  VEVE E+LA  EEA +  +DIIMLDNMSL+Q+ +A+ LI  +   E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGINLENVVQVAETGVDLVSLGWLTHSVRALDLSLN  274
            G I++  + +    ++D VS G LTHS ++LD+S++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

162) nadC in NC_002950


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (655),  Expect = 7e-46, Method: Compositional matrix adjust.
 Identities = 121/264 (46%), Positives = 176/264 (67%), Gaps = 3/264 (1%)

Query  10   AIAEDIADGDISSNAIIPQSEGAAATMVMKADGIISGMEVARRVFERFEA-VTW-TPY-V  66
            A+ ED+   D S+NAI+ +   A  ++  K  G+++G+ V +RVF  F+A VT   P   
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  67   SDGGSVKRGQVILRVEGSYRALLQAERLALNFLQRMSGIATMTARYAEALKGTAVRLLDT  126
             DG+ +  G+++L + GS R+LL  ER+ALNFLQ++SGIA+MTA Y EAL +  ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  127  RKTAPGMRITDKMAVRHGGGHNHRMGLYDMIMLKDNHIKVAGGIPQAIEAARRALPLSIK  186
            RKT+P +R+ +K AVR GGG NHR  L D IMLKDNHI   G++ +AI  AR   P+   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  187  LEVETSNLAEVEEAVRYGADIIMLDNMDNDTMCEAVRLIAGRARTEASGNMTLERLQSVA  246
            +EVE  +LA  EEA   G DIIMLDNM  + + +A+ LIAGR+R E SGN+ +  +    
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  247  ETGVDYISVGALTHSVTAMDISMN  270
              ++DY+S G+LTHS  ++D+SM+
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

163) Rpal_1245 in NC_011004


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (656),  Expect = 7e-46, Method: Compositional matrix adjust.
 Identities = 114/277 (42%), Positives = 189/277 (69%), Gaps = 4/277 (1%)

Query  13   LSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVIAGLPLAIETFRQ  72
            L+P+ I D+++ AL ED+ ++ D ++ A + +  QA   L A++AGV+AGL +    F  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  73   LSTDVAITA--HARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLSGIATLTADYV  130
            + ++V++    + +DGD +++G  VL I G+ R++LT ER ALNF+ +LSGIA++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  131  RHTAGTKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGGIRPV  190
               ++ ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  G+++  
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  191  LEAARAKIGHLVKIEIEVDTLDQLREVLDTNLADVVLLDNMDLDTLKKAVAMSAGRVVLE  250
            +  ARA    +  +E+EV++L    E   + + D+++LDNM L+ + +A+++ AGR  +E
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  251  ASGGVTRESISSIAATGVDYASSGALTHSAPNFDVAL  287
             SG +   +IS + + ++DY SSG+LTHSA ++D ++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

164) Rru_A1432 in NC_007643


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (655),  Expect = 8e-46, Method: Compositional matrix adjust.
 Identities = 116/279 (42%), Positives = 190/279 (69%), Gaps = 4/279 (1%)

Query  8    AALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGLGCARSAF  67
            + L+PF ID++++ AL ED+ ++ D ++ A +    +A   + A+++G+LAGL   +  F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  68   ALLDDTVTFTTP--LEDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIATRTRR  125
            +L+D  VTF  P  + DG  +++G+ V E+ G+ R++L+ ER ALNFL HLSGIA+ T  
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  126  FGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGGSNHRFGLDDAVLIKDNHIAVAGGVS  185
            + +A+++ R ++  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHIA  G+V 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  186  AALSRARAGVGHMVRIEIEVDTLEQlaevlavggaevvllDNMDAPTLTRAVDMVAGRLV  245
             A+++ARA    +  +E+EV++L   AE  A +G ++++LDNM    + +A+ ++AGR  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  246  TEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGL  284
             E SG + + TI+ +   ++DY+S G+LTHS  +LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

165) F11_07395 in NC_017584


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (655),  Expect = 8e-46, Method: Compositional matrix adjust.
 Identities = 116/279 (42%), Positives = 190/279 (69%), Gaps = 4/279 (1%)

Query  8    AALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGLGCARSAF  67
            + L+PF ID++++ AL ED+ ++ D ++ A +    +A   + A+++G+LAGL   +  F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  68   ALLDDTVTFTTP--LEDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIATRTRR  125
            +L+D  VTF  P  + DG  +++G+ V E+ G+ R++L+ ER ALNFL HLSGIA+ T  
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  126  FGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGGSNHRFGLDDAVLIKDNHIAVAGGVS  185
            + +A+++ R ++  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHIA  G+V 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  186  AALSRARAGVGHMVRIEIEVDTLEQlaevlavggaevvllDNMDAPTLTRAVDMVAGRLV  245
             A+++ARA    +  +E+EV++L   AE  A +G ++++LDNM    + +A+ ++AGR  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  246  TEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGL  284
             E SG + + TI+ +   ++DY+S G+LTHS  +LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

166) Desor_0089 in NC_016584


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  177 bits (654),  Expect = 9e-46, Method: Compositional matrix adjust.
 Identities = 120/275 (44%), Positives = 188/275 (69%), Gaps = 5/275 (1%)

Query  4    MSQFQ--ELINQALKEDIGTGDLSTR-IFSEDLTSSAKLYAKQEGVIAGLALVEQVF--Y  58
            ++ FQ  + ++ AL+ED+ + D ST  IF ++  +   L+AK+ GV+AGL++ ++VF  +
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  59   SVDPRIHIRPLVKDGDRVKVGDIVIELDGPLSSILQGERTALNFLQHLSGIATATKRAVD  118
              +  ++     KDGDR+  GD+V+E+ G++ S+L  ER ALNFLQHLSGIA+ T   V+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  QVAGLSTAIVDTRKTLPGWRALQKYAVRVGGGQNHRFGLYDAVMLKDNHLAAVGGLTEAV  178
             +++    + DTRKT P  R ++KYAVRVGGG NHRF L DA+MLKDNH+AAVG++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  QRTRDQIGHMVKIEVECETFEQVKEAVACGVDVIMLDNMGIEDMRRAVSYIDRRAVVEAS  238
             ++R     +  +EVE E++    EA A GVD+IMLDNM++E++ +A++ I  R+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGIQEETLRQVAETGVDLISIGALTHSVKAVDFSL  273
            G I+  T+ +    ++D +S G+LTHS K++DFS+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

167) nadC in NC_015571


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  176 bits (653),  Expect = 1e-45, Method: Compositional matrix adjust.
 Identities = 121/264 (46%), Positives = 176/264 (67%), Gaps = 3/264 (1%)

Query  15   AIAEDIADGDISSNAIIPQSEGAAATMVMKADGIISGMEVARRVFERFEA-VTW-TPY-V  71
            A+ ED+   D S+NAI+ +   A  ++  K  G+++G+ V +RVF  F+A VT   P   
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  72   SDGDSVKRGQVILRVDGSYRALLQAERLALNFLQRMSGIATMTARYAEALKGTAVRLLDT  131
             DGD +  G+++L + GS R+LL  ER+ALNFLQ++SGIA+MTA Y EAL +  ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  132  RKTAPGMRITDKMAVRHGGGHNHRMGLYDMIMLKDNHIKVAGGIPQAIEAARRALPLSIK  191
            RKT+P +R+ +K AVR GGG NHR  L D IMLKDNHI   G++ +AI  AR   P+   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  192  LEVETSNLAEVEEAVRYGADIIMLDNMDNDTMCEAVRLIADRARTEASGNMTLERLQSVA  251
            +EVE  +LA  EEA   G DIIMLDNM  + + +A+ LIA+R+R E SGN+ +  +    
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  252  ETGVDYISVGALTHSVTAMDISMN  275
              ++DY+S G+LTHS  ++D+SM+
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

168) nadC in NC_007775


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  176 bits (653),  Expect = 1e-45, Method: Compositional matrix adjust.
 Identities = 124/272 (46%), Positives = 197/272 (73%), Gaps = 2/272 (0%)

Query  6    YIPEETLCAWLQEDLGHGDLTSELTLPPSVEGEAVILAKEPGILAGLEIARRVFRLVDPQ  65
            +  ++TL A L+ED+   D +++  +    ++   ++AKE+G+LAGL + +RVF L D++
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  66   LAFAS--QVEEGASVVAGQEVVQIKGSLRGILAAERLALNLLQRLSGIATLTRTYVEALR  123
            ++F +  Q  +G  + +G+ V++I GS+R++L+ ER+ALN+LQ+LSGIA++T +YVEAL 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  124  GTSTQLLDTRKTTPGLRALEKYAVRVGGGKNHRFGLFDGILIKENHIRGAGGILAAVQRA  183
            +   +++DTRKTTP LR +EKYAVRVGGG NHRF L D+I++K+NHI + G++  A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  184  KAGAPHHLKVEVEVRNlqeleealaagadlillDNFPLEQIRAAVQRVGGKVPLEASGNM  243
            +A AP    VEVEV +L   EEA AAG D+I+LDN +LEQI  A+  ++G+  +E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  244  NLERARKAAEAGVDYISVGALTHSAKALDLSL  275
            ++    +    ++DY+S G+LTHSAK+LD+S+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

169) Pjdr2_0070 in NC_012914


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  176 bits (652),  Expect = 1e-45, Method: Compositional matrix adjust.
 Identities = 118/271 (44%), Positives = 190/271 (71%), Gaps = 5/271 (1%)

Query  15   EQIRSWLAEDIGSGDITTATTIPMGSHSTAVIHVKESGIIAGLPVAQIVFEIVDPELQFE  74
            + +++ L ED+ S D +T + +   +++   +  KE+G++AGL V Q VF + D+E+ F+
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  75   A--KVQDGEHVEKGTVIATVEGSTHSLLTGERLALNLMQRLSGIATKTNAFVAALEGLPV  132
               + +DG+++  G ++  + GS +SLLT ER+ALN++Q+LSGIA+ T A+V AL +  +
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  133  RLVDTRKTTPGHRMLEKYAVRVGGGANHRFGLYDAVMIKDNHIKGAGGIRQAVEASRAAI  192
            ++ DTRKTTP  R++EKYAVRVGGG NHRF L DA+M+KDNHI + G++++A+  +RA  
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  193  PHTMKIEVEAESLGQVEEALASGADIIMLDNMASTLMTEAVSLIKSRSPHVIVEASGNVR  252
            P    +EVE ESL+  EEA A+G DIIMLDNM+   + +A++LI +RS    +E SGN+ 
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNID  251

Query  253  LDTVRAIAACGVDVISVGGLTYSFNALDISL  283
            + T+  + + ++D +S G+LT S ++LD+S+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

170) nadC in NC_014328


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  176 bits (651),  Expect = 1e-45, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 189/271 (70%), Gaps = 2/271 (0%)

Query  6    VDKLIKNALIEDINYGDVTTDNLLLGSEVSKGRFIAKEPGVIAGIDVAKRVFEIVDSSII  65
            +D  +K AL ED++  D +T+ ++     +K  ++AKE+GV+AG+ V +RVF + D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   FNV--KIKDSSKVEKGDVIVELEGNSKSILKGERVALNILQRMCGIATKTNRMVDLVKDY  123
            F+   ++KD+ ++  GD+++E+ G+ +S+L  ERVALN+LQ++ GIA+ T   V+ + D 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  124  DVKIVDTRKTLPGFRILDKYSVTAGGGYNHRLNLSDFVMIKDNHIRAVGSITEAVKRIKN  183
             +K+ DTRKT P +R+++KY+V  GGGYNHR+NLSD +M+KDNHI AVGS+  A+ + + 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  184  KIPFTAKVEVEVENLDQLKEAVNTEVDVIMLDNMDVDTMRKAVKFVNKKFILEASGNVTE  243
              PF   VEVEVE+L    EA  + VD+IMLDNM ++ + +A+ ++  +  +E SGN+  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  244  NTIGDIASTGVDIISIGSLTHSVKALDISLR  274
             TI+ + + ++D +S GSLTHS K+LD+S++
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

171) Anacy_1478 in NC_019771


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  176 bits (650),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 112/265 (43%), Positives = 179/265 (68%), Gaps = 6/265 (2%)

Query  23   EDIGRGDRTTESLLSENATPGQAQWIAKAPGIIAGLPIASRVFQLLNDQVSFVG--LVPE  80
            ED+   D +T++++ +++  ++   +AK +G++AGL +  RVF L++ +V+F       +
Sbjct  23   EDVHSEDYSTNAIFDHHG-QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKD  81

Query  81   GAKCEPGQMIAQINGSLDALLMGERVALNLAMRLSGIATLTNIYVEKIADLPVQLVDTRK  140
            G +  +G+++ +I GS+ +LL  ERVALN+  +LSGIA++T  YVE ++D  +++ DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  141  TTPGLRLLEKYATVVGGGTNHRMGLDDAVMIKDNHIAAVGGIGEAVIQIRSRIPYPLTIE  200
            TTP LRL+EKYA  VGGG NHR  L DA+M+KDNHIAAVG++  A+ Q R+  P+   +E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  201  VETENLGQVQEALQHKADIIMLDNMPLNMILEAVQLIRSQDNRVKIEASGNVTLETIRTV  260
            VE E+L+  +EA     DIIMLDNM+L+ I +A+ LI     R +IE SGN+ + TI   
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRF  258

Query  261  AETGVDYISTSAPITQSRWLDLSMR  285
               ++DY+S+++    ++ LD+SM+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

172) nadC in NC_009706


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (649),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 118/271 (44%), Positives = 193/271 (72%), Gaps = 2/271 (0%)

Query  6    IDELIKNGLIEDINYGDVTTDNLFHGQEISKGKFIAKEHGIIAGIEVAERVFQILDSSIV  65
            ID+ +K +L ED++  D +T+ +F+ +  +K  ++AKE G++AG+ V +RVF ++D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   FKK--YLKDGHEVKRGDTIAYIEGSSNSILKGERVALNILQRMCGIATKTFKIVQLVKDY  123
            F++   +KDG+ +  GD +  I GS  S+L  ERVALN+LQ++ GIA+ T   V+ + D 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  124  DVKIVDTRKTLPGFRILDKYSVRMGGGYNHRLNLSDFVMIKDNHIKAVGSIKEAVERIKS  183
             +K+ DTRKT P +R+++KY+VR+GGGYNHR+NLSD +M+KDNHI AVGS++ A+ + ++
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  184  KIPFTTKIEVEVENFYQLKEALDAKVDVIMLDNMDVEHMKKAVEFVDKRVFLEASGNVNE  243
              PF   +EVEVE++    EA  A VD+IMLDNM +E++ +A+ ++  R  +E SGN++ 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  244  NNVADIASTGVDIISMGSLTHSVKALDISLK  274
              ++ + + ++D +S GSLTHS K+LD+S+K
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

173) CKR_0671 in NC_011837


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (649),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 118/271 (44%), Positives = 193/271 (72%), Gaps = 2/271 (0%)

Query  6    IDELIKNGLIEDINYGDVTTDNLFHGQEISKGKFIAKEHGIIAGIEVAERVFQILDSSIV  65
            ID+ +K +L ED++  D +T+ +F+ +  +K  ++AKE G++AG+ V +RVF ++D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   FKK--YLKDGHEVKRGDTIAYIEGSSNSILKGERVALNILQRMCGIATKTFKIVQLVKDY  123
            F++   +KDG+ +  GD +  I GS  S+L  ERVALN+LQ++ GIA+ T   V+ + D 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  124  DVKIVDTRKTLPGFRILDKYSVRMGGGYNHRLNLSDFVMIKDNHIKAVGSIKEAVERIKS  183
             +K+ DTRKT P +R+++KY+VR+GGGYNHR+NLSD +M+KDNHI AVGS++ A+ + ++
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  184  KIPFTTKIEVEVENFYQLKEALDAKVDVIMLDNMDVEHMKKAVEFVDKRVFLEASGNVNE  243
              PF   +EVEVE++    EA  A VD+IMLDNM +E++ +A+ ++  R  +E SGN++ 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  244  NNVADIASTGVDIISMGSLTHSVKALDISLK  274
              ++ + + ++D +S GSLTHS K+LD+S+K
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

174) Flexsi_1006 in NC_015672


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (649),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 116/276 (43%), Positives = 183/276 (67%), Gaps = 2/276 (0%)

Query  2    LKNYLVDKLIELALLEDIGHGDITTESIFKENNTGRFHFLAKEDMVLCGTEVVKKVFSNM  61
            L  + +D  +  AL ED+   D +T++IF ++  ++  ++AKE  VL G  V ++VF+  
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  62   NSNI--ETTFHFKDGDKIQQNTYFGEVTGTVSSILTGERTALNFLQRLSGIATNTRRYTA  119
            ++++  +   +FKDGD++       E+ G+V S+LT ER ALNFLQ+LSGIA+ T  Y  
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  120  CLKNSDIKILDTRKTTPGHRVLEKYAVKIGGGANHRFGLFDGVLIKDNHIDAAGSIFEAV  179
             L +  IK++DTRKTTP  R++EKYAV++GGG NHRF L D++++KDNHI A GS+  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  180  KNAKESIPSTVKIEVEIRNLTELQQAVKAGADIVMLDNFKREDIIEACKIVNKRAKIEIS  239
             +A+   P    +EVE+ +L+  ++A  AG DI+MLDN   E+I +A  ++  R++IE S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  240  GGITLKEIDGLKKYDIDYISVGALTHSSGNIDISLK  275
            G I +  I  ++   IDY+S G+LTHS+ ++D+S+K
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

175) nadC in NC_013768


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (649),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 112/279 (41%), Positives = 191/279 (69%), Gaps = 4/279 (1%)

Query  1    MNSILMNQAIQAFLLEDIGQHDLSSDSIFSSETMGEGVFIAKETGILCGIAIPRVVYEIL  60
            + ++ ++++++A L ED+  +D S+++IF  +  +   ++AKE+G+L G+++ + V+ ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   GGNVHFEAVK--KDGETIKKGEIIATVSAPVRTLLSGERVILNLMQRMSGIATQTHIAVK  118
            +++V F+     KDG+ +  G+++  + ++VR+LL+ ERV LN++Q++SGIA+ T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  QLDDSTIRICDTRKTAPGLRAFDKYAVQSGGGFNHRNGLYDGVMLKDNHIAFSGGITEAV  178
             L+D  I++ DTRKT+P LR F+KYAV+ GGG+NHR  L D++MLKDNHIA  G++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  STVREKLGHMVKIEVETETASQVKEAVQAGADIIMFDNRTPEEIKQLVTLVPNHITTEIS  238
            +  R     +  +EVE E+ +   EA  AG DIIM+DN + E+I Q +TL++ +   E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNITLDNINHYRGSGANYISLGSLTHSVSALDISFNSKG  277
            GNI +  I+++RG + +Y+S GSLTHS  +LD  F+ KG
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD--FSMKG  284

176) nadC in NC_013766


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (649),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 112/279 (41%), Positives = 191/279 (69%), Gaps = 4/279 (1%)

Query  1    MNSILMNQAIQAFLLEDIGQHDLSSDSIFSSETMGEGVFIAKETGILCGIAIPRVVYEIL  60
            + ++ ++++++A L ED+  +D S+++IF  +  +   ++AKE+G+L G+++ + V+ ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   GGNVHFEAVK--KDGETIKKGEIIATVSAPVRTLLSGERVILNLMQRMSGIATQTHIAVK  118
            +++V F+     KDG+ +  G+++  + ++VR+LL+ ERV LN++Q++SGIA+ T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  QLDDSTIRICDTRKTAPGLRAFDKYAVQSGGGFNHRNGLYDGVMLKDNHIAFSGGITEAV  178
             L+D  I++ DTRKT+P LR F+KYAV+ GGG+NHR  L D++MLKDNHIA  G++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  STVREKLGHMVKIEVETETASQVKEAVQAGADIIMFDNRTPEEIKQLVTLVPNHITTEIS  238
            +  R     +  +EVE E+ +   EA  AG DIIM+DN + E+I Q +TL++ +   E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNITLDNINHYRGSGANYISLGSLTHSVSALDISFNSKG  277
            GNI +  I+++RG + +Y+S GSLTHS  +LD  F+ KG
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD--FSMKG  284

177) Clo1100_4098 in NC_016791


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (647),  Expect = 3e-45, Method: Compositional matrix adjust.
 Identities = 127/272 (47%), Positives = 191/272 (71%), Gaps = 4/272 (1%)

Query  8    IHEIVMNALKEDMPLGDITTDNIISEGDASKAEFLAKQDAVIAGLDVAKYVFEVLDSGVC  67
            I++ +  AL+ED+   D +T+ I+ + + +K  ++AK+ +V+AGL V + VF ++D+ V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   FKA---FVKDGDKISKGDIIAEVSGPTRALLKGERTALNFMQRLSAIATMTNRYVNKVQG  124
            F+    F KDGD+++ GD++ E+ G+ R+LL  ER ALNF+Q+LS+IA+MT  YV+ + +
Sbjct  73   FQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  125  LPVKVTDTRKTTPGLRLLEKYAVNAGGGANHRFSLSDGVLIKDNHIAAAGGIRNAVERVR  184
              +KV DTRKTTP LRL+EKYAV  GGG NHRF+LSD++++KDNHIAA G++++A+ + R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  185  KSIPHTvkievevesmeevrealeCKADIIMLDNMSNEQMTEAVKFIDKRALVEASGNIS  244
               P    +EVEVES+    EA     DIIMLDNMS EQ+ +A+ +I  R+ +E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  245  EETIYNVALTGVDIISIGKLTHSANSVDISMN  276
              TI      ++D +S G LTHSA+S+D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

178) Ccel_3478 in NC_011898


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (647),  Expect = 3e-45, Method: Compositional matrix adjust.
 Identities = 128/277 (47%), Positives = 190/277 (69%), Gaps = 4/277 (1%)

Query  3    LSNLYIHEIVMNALKEDMPLGDITTDNILSEGDSSRAEFMAKQDAVIAGLDVAKYVFEVL  62
            L+ + I++ +  AL+ED+   D +T+ I+ + + ++  + AK+ +V+AGL V + VF ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DSGICFKA---FVKDGDKVSKGDIIAEVSGSTRALLKGERTALNFMQRLSAIATMTNRYV  119
            D+ + F+    F KDGD+++ GD++ E+ GS R+LL  ER ALNF+Q+LS+IA+MT  YV
Sbjct  68   DAEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  SKVQGLPVKVTDTRKTTPGLRLLEKYAVSAGGGANHRFSLSDGVLIKDNHIAAAGGITNA  179
              + +  +KV DTRKTTP LRL+EKYAV  GGG NHRF+LSD++++KDNHIAA G++ +A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  VQRVRNSIPHTvkievevesmeevrealeCKADIIMLDNMSNEQMAEAVKLINKRALAEA  239
            + + R   P    +EVEVES+    EA     DIIMLDNMS EQ+ +A+ LI  R+  E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  240  SGNISEETIYNVALTGVDIISIGKLTHSANSIDISMN  276
            SGNI   TI      ++D +S G LTHSA+S+D+SM+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

179) Cabther_A0092 in NC_016024


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  175 bits (648),  Expect = 3e-45, Method: Compositional matrix adjust.
 Identities = 115/282 (41%), Positives = 190/282 (68%), Gaps = 8/282 (2%)

Query  3    LDPVAIENLIAQFLAEDIGRGDVTTDAILTHEVRARGRFLAKQELILAGIEVAEMVFQWF  62
            L P  I++ +   L ED+   D +T+AI+ H+ +A+  ++AK+  +LAG+ V + VF  F
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DPEIQIQTF--YLDGDTVPAGKEIARVAGPAHMLLAGERVALNLLQRMSGIATLTHAFVQ  120
            D+E+ +Q    + DGD + +G  +  + G+ + LL+ ERVALN+LQ++SGIA++T A+V+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  121  AIEGTSAVIADTRKTAPGLRLLDKYAVHVGGGHNHRFGLDDGILIKDNHIALAGGIGRAL  180
            A+ +    + DTRKT+P LRL++KYAV+VGGG NHRF L D+I++KDNHIA  G++ +A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  181  RLAKKNASHLLKIEIEVSTLEQVQEAVAEGADVILLDNMTVDQVRACVALIRELEPPGRQ  240
              A+  A+ +  +E+EV +L   +EA A G D+I+LDNM+++Q+   ++LI     +GR 
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI-----AGRS  242

Query  241  TLVEVSGNISLDNVRAYAEAGANLISVGALTHSVKAADISLK  282
              +E SGNI +  +  +   + + +S G+LTHS K+ D+S+K
Sbjct  243  R-IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

180) Rumal_3121 in NC_014833


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  174 bits (644),  Expect = 5e-45, Method: Compositional matrix adjust.
 Identities = 123/277 (45%), Positives = 179/277 (65%), Gaps = 4/277 (1%)

Query  3    LMQFQIDDIIKTALLEDINYIDVTTDLLVSDDAVSTAKYVSKDEGILCGIEVALRVFKLL  62
            L  FQIDD +K+AL ED++  D +T+ +  +++ +     +K+ G+L G+ V  RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DDRVSF---RIFIHDGEVVQKGDIIAEITGPTRALLKGERTALNLVQHMSGIATATNKCV  119
            D  V+F   + F  DG+ +  GD++ EI G+ R+LL  ER ALN++QH+SGIA+ T   V
Sbjct  68   DAEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  QLIEGTKASVADTRKTLPGLRAIQKYAVTVGGGKNHRYNLSDCAMLKDTHLDAYGSMTGA  179
            + + + +  V DTRKT P LR ++KYAV VGGG NHR+NLSD  MLKD H+ A GS+  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  VNALREKAGHTVKIEVEVADMDMLKEALDLGVEIIMLDNMSNEEMAEAVKLTNGRALLEA  239
            +   R  A     +EVEV  +    EA   GV+IIMLDNMS E++ +A+ L  GR+ +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  240  SGNVTEKTIRGIAETGVDIISLGALTHSVKAFDISMK  276
            SGN+   TI  +   ++D +S G+LTHS K++D+SMK
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

181) nadC in NC_008358


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  174 bits (643),  Expect = 7e-45, Method: Compositional matrix adjust.
 Identities = 118/268 (45%), Positives = 190/268 (71%), Gaps = 4/268 (1%)

Query  17   VRLALAEDLGRAGDLTTDATIPPETQLSVVIAARKPGVIAGLDVAAYSASLVDPALKLEI  76
            ++ AL ED+ ++ D +T+A +  + Q  V + A+ +GV+AGL V     +L D+ + ++ 
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  77   EKP--DGSALTPGDVVARLSGSARSILTAERTMLNFLGRLSGVASLTRQYVDAVAHTKTR  134
                 DG  LT+GD+V  + GS RS+LT ER  LNFL +LSG+AS+T  YV+A+++ + +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  135  IVCTRKTTPGHRALEKRAVRCGGGTSHRYGLDDAILIKDNHIAACGGSIEATLERAKAYA  194
            +  TRKTTP  R +EK AVR GGG +HR+ L DAI++KDNHIAA  GS++ ++ +A+AYA
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA-VGSVQKAIAQARAYA  194

Query  195  GHLRMIEIEVDTLAQLEEALKYGPHAILLDNMSLEQLREAVTITGGRVPLEASGGVTLTS  254
              ++M+E+EV++LA  EEA   G + I+LDNMSLEQ+ +A+T+ +GR  +E SG + +T+
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  255  VAAIAETGVDFISSGALTHSAPNLDLGL  282
            ++ +   ++D++SSG+LTHSA +LD+++
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

182) nadC in NC_012440


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 116/244 (48%), Positives = 169/244 (70%), Gaps = 4/244 (1%)

Query  34   DIKASVIAKEDGIIAGIDFAKEVFLILDRDIRF--PFSLKDGSEVKKGDTVLSVEGSAVS  91
            + K S++AKE G++AG+   + VF ++D ++ F  P  +KDG  +  GD VL + GS  S
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  92   VLKGERVALNILQRLSGIATTASRYAEKIKDLKTRILDTRKTTPGFRAFEKYAVKVGGGS  151
            +L  ERVALN+LQ+LSGIA+ ++ Y E + D + +++DTRKTTP +R FEKYAV+VGGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  152  NHRFALYDMVMIKDNHIAVCGGITKAVNRIRENVSPMVK-IEVEVSDLNQLKEALSLNVD  210
            NHRF L D +M+KDNHIA  G++ KA+ + R   +P VK +EVEV  L    EA +  VD
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY-APFVKMVEVEVESLAAAEEAAAAGVD  219

Query  211  IIMLDNMSLEMLKEAVNIVNGKVLLEASGNITVENVRDVALTGVDFISSGSIIHSSRWLD  270
            IIMLDNMSLE + +A+ ++ G+  +E SGNI +  +      ++D++SSGS+ HS++ LD
Sbjct  220  IIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD  279

Query  271  LSMK  274
            +SMK
Sbjct  280  FSMK  283

183) nadC in NC_000964


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 183/260 (71%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDENV--QSILHKKDG  72
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D +V  Q+  + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGITLESLPAFKGTG  252
            E+E+     EA AAG D+IM+DN + + + +   L ++  + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

184) nadC in NC_020507


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 183/260 (71%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDENV--QSILHKKDG  72
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D +V  Q+  + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGITLESLPAFKGTG  252
            E+E+     EA AAG D+IM+DN + + + +   L ++  + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

185) nadC in NC_018520


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 183/260 (71%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDENV--QSILHKKDG  72
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D +V  Q+  + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGITLESLPAFKGTG  252
            E+E+     EA AAG D+IM+DN + + + +   L ++  + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

186) Npun_F5252 in NC_010628


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (640),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 114/265 (44%), Positives = 177/265 (67%), Gaps = 6/265 (2%)

Query  23   EDIGRGDRTTNTLLVEDVTLGSAKWIAKASGITAGLPIAARVFQILNEKVSFTAV--VAE  80
            ED+   D +TN+++ ++   +    +AK +G+ AGL +  RVF +++  V+F       +
Sbjct  23   EDVHSEDYSTNAIF-DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKD  81

Query  81   GTWCEPGQVVAEIDGSLDALLMGERVALNLAMRLSGIATLTNIYVEKIADLPAQLVDTRK  140
            G +  +G++V EI GS+ +LL  ERVALN+  +LSGIA++T  YVE ++D   ++ DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  141  TTPGLRLLEKYATAVGGAINHRMGLDDAVMIKDNHIAAAGGIEKAVTRIRSQIPYPLTIE  200
            TTP LRL+EKYA  VGG+ NHR  L DA+M+KDNHIAA G+++KA+++ R+  P+   +E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  201  VETESLEQVKEALQHDVDIIMLDNMPVDMMREAVQLIRQQDSRVKIEASGNVTLETIRGV  260
            VE ESL    EA   +VDIIMLDNM+++ + +A+ LI    +R +IE SGN+ + TI   
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRF  258

Query  261  AETGVDYISSSAPITQSKWLDLSMR  285
               ++DY+SS++    +K LD+SM+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

187) nadC in NC_019427


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 112/270 (42%), Positives = 179/270 (67%), Gaps = 6/270 (2%)

Query  24   EDIGRGDRTTQSLLSPNSARGQAKWIAKAPGIIAGLPVAARVFKLLNNEVDFISLTD--E  81
            ED+   D +T++++  + ++++   +AK +G++AGL V  RVF L++ EV F +  +  +
Sbjct  23   EDVHSEDYSTNAIFDHH-GQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKD  81

Query  82   GTPSEPGQVIAEINGSLDTLLMGERVALNLVMRLSGIASLTNIYVKKIADLPAQLVDTRK  141
            G    +G+++ EI GS+ +LL  ERVALN++ +LSGIAS+T  YV  ++D   ++ DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  142  TTPGLRILEKYASALGGAMNHRMGLDDAVMIKDNHIVAAGGIGEAVTRIRSHVPYPLTIE  201
            TTP LR++EKYA  +GG+ NHR  L DA+M+KDNHI A G++  A+++ R+  P+   +E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  202  VETENLAQVREALQHKVDIIMLDNMSLSMMSEAVLLIREEDSRVKIEASGNVTLETVRAV  261
            VE E+LA   EA    VDIIMLDNMSL  + +A+ LI    +R +IE SGN+ + T+   
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRF  258

Query  262  AETGVDYISTSAPITQSKWLDLSMRMVNCL  291
               ++DY+S+++    +K LD+SM+ +  L
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

188) nadC in NC_008702


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (640),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 109/272 (41%), Positives = 186/272 (69%), Gaps = 3/272 (1%)

Query  10   EIQRNVSASLAEDIGTGDLTAR-LIAAETEARGRVITREDAVVCGTAWFDATFAALSPTT  68
            +I+  + A+L ED+ + D ++  ++  + +A+  ++++E +V+ G + F+  F+ + +  
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  69   SVL--WHVRDGERVEAGQLLCEVDASARVLLTAERTALNFLQLLSGTATVTRRFVDAVAG  126
            +     + +DG+R+ +G+L+ E+ +S R LLT ER ALNFLQ LSG A++T  +V+A+++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  127  TRAKIVDTRKTLPGLRLAQKYAVSVGGGTNHRVGLYDGILVKENHIIAAGGIRQVVEQAR  186
             R K+ DTRKT P LRL +KYAV VGGG NHR  L D+I++K+NHI A G++++ + QAR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  187  AIAPSNVFIEVEVENLDELREALDAGVTMVLLDNMSLEEMREAVRITAGRAELEASGGVN  246
            A AP    +EVEVE+L    EA  AGV +++LDNMSLE++ +A+ + AGR+ +E SG ++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  247  LERVRAIAETGVDRISIGSLTKDVRALDLSLR  278
            +  +  +   ++D +S GSLT   ++LD+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

189) nadC in NC_017538


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 110/272 (41%), Positives = 188/272 (70%), Gaps = 4/272 (1%)

Query  2    IEDAVRHALSEDLGRAGDVTSIATIPDGMPARAVMVARQAGTIAGLPLAVTAFRMLAPDI  61
            I+D+++ AL ED+ ++ D ++ A + +   A+  + A++AG +AGL +    F ++ +++
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  62   EIEAGA--RDGDTVTKGQPLLTFAGSARAVLSAERVALNYVGRLSGIATLTANYVKETAG  119
             ++     +DGD +T G+ +L + GS R++L+ ERVALN++ +LSGIA++TA YV   ++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  120  TKLRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGSIAAVLTRAR  179
             ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  GS+   +++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  180  AVAGHLVKIEIEVDTLDQLREVLATGLADVVLLDNMDIPTLREAVALTAGRVVLEVSGGV  239
            A A  +  +E+EV++L    E  A+G+ D+++LDNM +  + +A++L AGR  +E SG +
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  240  TVERIAEIAKTGVDYASSGALTHSAPNFDVAL  271
             +  I+ +   ++DY SSG+LTHSA ++D ++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

190) nadC in NC_011386


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 110/272 (41%), Positives = 188/272 (70%), Gaps = 4/272 (1%)

Query  23   IEDAVRHALSEDLGRAGDVTSIATIPDGMPARAVMVARQAGTIAGLPLAVTAFRMLAPDI  82
            I+D+++ AL ED+ ++ D ++ A + +   A+  + A++AG +AGL +    F ++ +++
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  83   EIEAGA--RDGDTVTKGQPLLTFAGSARAVLSAERVALNYVGRLSGIATLTANYVKETAG  140
             ++     +DGD +T G+ +L + GS R++L+ ERVALN++ +LSGIA++TA YV   ++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  141  TKLRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGSIAAVLTRAR  200
             ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  GS+   +++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  201  AVAGHLVKIEIEVDTLDQLREVLATGLADVVLLDNMDIPTLREAVALTAGRVVLEVSGGV  260
            A A  +  +E+EV++L    E  A+G+ D+++LDNM +  + +A++L AGR  +E SG +
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  261  TVERIAEIAKTGVDYASSGALTHSAPNFDVAL  292
             +  I+ +   ++DY SSG+LTHSA ++D ++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

191) nadC in NC_015684


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 110/272 (41%), Positives = 188/272 (70%), Gaps = 4/272 (1%)

Query  2    IEDAVRHALSEDLGRAGDVTSIATIPDGMPARAVMVARQAGTIAGLPLAVTAFRMLAPDI  61
            I+D+++ AL ED+ ++ D ++ A + +   A+  + A++AG +AGL +    F ++ +++
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  62   EIEAGA--RDGDTVTKGQPLLTFAGSARAVLSAERVALNYVGRLSGIATLTANYVKETAG  119
             ++     +DGD +T G+ +L + GS R++L+ ERVALN++ +LSGIA++TA YV   ++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  120  TKLRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNHIAVAGSIAAVLTRAR  179
             ++++  TRKTTP LR +EKYAVR GGG+NHRF L DAI++KDNHIA  GS+   +++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  180  AVAGHLVKIEIEVDTLDQLREVLATGLADVVLLDNMDIPTLREAVALTAGRVVLEVSGGV  239
            A A  +  +E+EV++L    E  A+G+ D+++LDNM +  + +A++L AGR  +E SG +
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGV-DIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  240  TVERIAEIAKTGVDYASSGALTHSAPNFDVAL  271
             +  I+ +   ++DY SSG+LTHSA ++D ++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

192) nadC in NC_020062


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (639),  Expect = 1e-44, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 190/278 (69%), Gaps = 3/278 (1%)

Query  4    APLPRLIVEPLVRNALAEDLGLAGDVTATAVIPAEHRSRVAMVTRQPGVVAGLDASELAF  63
            + L  + ++  ++ AL ED+  + D ++ A++  + +++V++ ++++GV+AGL   +  F
Sbjct  6    TDLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   QLVDPAIAM--TRHVPDGTKVEAGDVIATIEGPSRGLLTAERTALNFLGHLSGIASVTAS  121
             L D+ ++    ++  DG ++ +GD++  I G+ R+LLT ER ALNFL HLSGIAS+TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  122  IVEAIAGTKASIVCTRKTTPGLRALEKYAVRAGGGINHRFALYDAVLIKDNHVAIAGGIT  181
             VEA+++ +  +  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNH+A  G++ 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  EAIRRAKAGVGHMVKIEVEVDTLAQLREAMQEGVDAVLLDNMTPDQLREAVDIVGGGAIT  241
             AI +A+A    +  +EVEV++LA   EA   GVD ++LDNM+ +Q+ +A+ +++G +  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  242  EASGRitpataaaiaaSGVDLISIGWLTHSAPTLDIGL  279
            E SG I  +T + + + ++D +S G LTHSA +LD+++
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

193) Caur_0893 in NC_010175


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 8e-45, Method: Compositional matrix adjust.
 Identities = 121/281 (44%), Positives = 185/281 (66%), Gaps = 8/281 (2%)

Query  2    ELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFRQ  61
            +L    +D  +  AL EDV + D +T + +    Q+   +  +EAGV+AGL V   VF  
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   LDPGVAVQ--CHVAEGAAVSAGTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYV  119
            +D+ V+ Q   +  +G  +++G  +  I GS RS+LT ERVALN+LQ+LSGIA++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  AAIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLYDGVMLKDNHLAILAAQGID  179
             A+++ + K++DTRKTTP LR +EKYAVRVGGGYNHRF L D++MLKDNH+A +++    
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  LAGAIRHVRRQLGPMVRLevevesv-aaaivaaeagaDLILLDNMPPDQLRLAVQAVAGR  238
            +A A     R  +P V++        AAA  AA AG D+I+LDNM+ +Q+  A+  +AGR
Sbjct  187  IAQA-----RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  239  AKTEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGL  279
            ++ E SG + + T+  +   ++DY+S G+LTHS ++LD+++
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

194) Chy400_0971 in NC_012032


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 8e-45, Method: Compositional matrix adjust.
 Identities = 121/281 (44%), Positives = 185/281 (66%), Gaps = 8/281 (2%)

Query  2    ELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFRQ  61
            +L    +D  +  AL EDV + D +T + +    Q+   +  +EAGV+AGL V   VF  
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   LDPGVAVQ--CHVAEGAAVSAGTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYV  119
            +D+ V+ Q   +  +G  +++G  +  I GS RS+LT ERVALN+LQ+LSGIA++TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  120  AAIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLYDGVMLKDNHLAILAAQGID  179
             A+++ + K++DTRKTTP LR +EKYAVRVGGGYNHRF L D++MLKDNH+A +++    
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  180  LAGAIRHVRRQLGPMVRLevevesv-aaaivaaeagaDLILLDNMPPDQLRLAVQAVAGR  238
            +A A     R  +P V++        AAA  AA AG D+I+LDNM+ +Q+  A+  +AGR
Sbjct  187  IAQA-----RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  239  AKTEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGL  279
            ++ E SG + + T+  +   ++DY+S G+LTHS ++LD+++
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

195) NadC in NC_020519


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 9e-45, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 190/275 (70%), Gaps = 6/275 (2%)

Query  4    HIDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            +ID  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++    S+  A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----SVQKAI  187

Query  182  SNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEAS  241
            ++ +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTAGKIASTGVDVISVGALTHSVHALDLGL  276
            G +++ T +++ + ++D +S G+LTHS  +LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

196) Cgl1068 in NC_003450


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 9e-45, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 190/275 (70%), Gaps = 6/275 (2%)

Query  4    HIDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            +ID  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++    S+  A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----SVQKAI  187

Query  182  SNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEAS  241
            ++ +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTAGKIASTGVDVISVGALTHSVHALDLGL  276
            G +++ T +++ + ++D +S G+LTHS  +LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

197) nadC in NC_006958


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 9e-45, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 190/275 (70%), Gaps = 6/275 (2%)

Query  4    HIDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            +ID  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++    S+  A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----SVQKAI  187

Query  182  SNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEAS  241
            ++ +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTAGKIASTGVDVISVGALTHSVHALDLGL  276
            G +++ T +++ + ++D +S G+LTHS  +LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

198) nadC in NC_022040


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  173 bits (641),  Expect = 9e-45, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 190/275 (70%), Gaps = 6/275 (2%)

Query  4    HIDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            +ID  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++    S+  A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----SVQKAI  187

Query  182  SNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEAS  241
            ++ +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTAGKIASTGVDVISVGALTHSVHALDLGL  276
            G +++ T +++ + ++D +S G+LTHS  +LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

199) nadC in NC_014614


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (636),  Expect = 2e-44, Method: Compositional matrix adjust.
 Identities = 110/265 (42%), Positives = 179/265 (68%), Gaps = 6/265 (2%)

Query  3    LEEDINNIDLASSVIFNEEHKSKSKFMAKEDGVICGWDIVRRVFELLKYEGEVKVLKP--  60
            L ED+++ D +++ IF+++ ++K  + AKE GV+ G  + +RVF L  +++EV   +P  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL--FDAEVTFQNPHQ  78

Query  61   --DGASVQKGECIAELYGRTKSLLMGERVALNILSHLSGISTKTNKAVSVLSRGNTKLLD  118
              DG  +  G+ + E+ G  +SLL  ERVALN+L HLSGI++ T   V  L+ +  K++D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  119  TRKTTPGLRMLEKYAVRTGGGVNHRYNLSQAVMIKDNHIKASGGITNAYDKVKSKSGPMT  178
            TRKTTP LR++EKYAVR GGG NHR+NLS+A+M+KDNHI A G++ +A  + ++ +  + 
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  179  AIEIEVKNIEELKEAIVLKPNLILLDNMNDNQLRECVNLCNGLVPLEASGNMTLERLDEI  238
             +E+EV ++    EA     ++I+LDNM+ +Q+ + + L  G   +E SGN+ +  +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  239  KDIGLDYVSMGELTHSVKALDISMK  263
            +++++DYVS G LTHS K+LD+SMK
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

200) nadC in NC_014483


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (637),  Expect = 2e-44, Method: Compositional matrix adjust.
 Identities = 114/274 (42%), Positives = 184/274 (68%), Gaps = 5/274 (1%)

Query  17   ELTAQIRSWLREDTGSGDVTTRWTIEQGHQSKAVIHAKESGVVAGIPVAALVFQVVDPSL  76
            ++   +++ LRED  S D +T   +++  Q+K  + AKE+GV+AG+ V   VF + D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  77   SF--TPLVVDGQWIEKGSVLAEVTGSTHAILTGERLALNLLQRMSGIATRTRNFIDQLHG  134
            +F       DG+++  G ++ E+ GS +++LT ER+ALN+LQ++SGIA+ T  +++ L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  135  LSTRLVDTRKTTPGHRLLEKYAVRVGGGSNHRFGLYDAVMIKDNHIKGAGGIEQAVSRAR  194
               ++ DTRKTTP  RL+EKYAVRVGGG NHRF L DA+M+KDNHI + G++++A+++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  195  AHIPHTMTIEVETENMKQVQEALEAGADIIMLDNMSVPDMKEAVRFIRERAPHVKTEASG  254
            A  P    +EVE E++   +EA  AG DIIMLDNMS+ ++ +A+ +I  R+   + E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSG  248

Query  255  NVSLDTVREMAESGVDVISVGRLTYSFHNLDISL  288
            N+ + T+      ++D +S G LT S  +LD+S+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

201) nadC in NC_017542


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (638),  Expect = 2e-44, Method: Compositional matrix adjust.
 Identities = 115/274 (42%), Positives = 184/274 (68%), Gaps = 5/274 (1%)

Query  17   ELTAQIRSWLREDTGSGDVTTRWTIEPGHQSKAVIHAKESGVIAGLPVAEIVFRVVDPSL  76
            ++   +++ LRED  S D +T   ++   Q+K  + AKE+GV+AGL V + VF + D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  77   SF--TPLVTDGQWIEKGSVLAEVSGSTHAILTGERLALNLLQRMSGIATRTRTFIDQLHG  134
            +F       DG+++  G ++ E+ GS +++LT ER+ALN+LQ++SGIA+ T ++++ L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  135  LSTRLVDTRKTTPGHRLLEKYAVRVGGGSNHRFGLYDAVMIKDNHIKGAGGIAQAVSRAR  194
               ++ DTRKTTP  RL+EKYAVRVGGG NHRF L DA+M+KDNHI + G++ +A+++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  195  AHIPHTMTIEVETENMTQVREALEAGADIIMLDNMSVPDMKEAVRFIREQAPHVKTEASG  254
            A  P    +EVE E+++   EA  AG DIIMLDNMS+ ++ +A+ +I   A + + E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSG  248

Query  255  NVSLDTVREMAESGVDVISVGRLTYSFHNLDISL  288
            N+ + T+      ++D +S G LT S  +LD+S+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

202) PPSC2_c0062 in NC_014622


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (638),  Expect = 2e-44, Method: Compositional matrix adjust.
 Identities = 115/274 (42%), Positives = 184/274 (68%), Gaps = 5/274 (1%)

Query  17   ELTAQIRSWLREDTGSGDVTTRWTIEPGHQSKAVIHAKESGVIAGLPVAEIVFRVVDPSL  76
            ++   +++ LRED  S D +T   ++   Q+K  + AKE+GV+AGL V + VF + D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  77   SF--TPLVTDGQWIEKGSVLAEVSGSTHAILTGERLALNLLQRMSGIATRTRTFIDQLHG  134
            +F       DG+++  G ++ E+ GS +++LT ER+ALN+LQ++SGIA+ T ++++ L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  135  LSTRLVDTRKTTPGHRLLEKYAVRVGGGSNHRFGLYDAVMIKDNHIKGAGGIAQAVSRAR  194
               ++ DTRKTTP  RL+EKYAVRVGGG NHRF L DA+M+KDNHI + G++ +A+++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  195  AHIPHTMTIEVETENMTQVREALEAGADIIMLDNMSVPDMKEAVRFIREQAPHVKTEASG  254
            A  P    +EVE E+++   EA  AG DIIMLDNMS+ ++ +A+ +I   A + + E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSG  248

Query  255  NVSLDTVREMAESGVDVISVGRLTYSFHNLDISL  288
            N+ + T+      ++D +S G LT S  +LD+S+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

203) cgR_1151 in NC_009342


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (637),  Expect = 2e-44, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 190/275 (70%), Gaps = 6/275 (2%)

Query  4    HTDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRI  63
            + D  + AAL ED    D ++++++   +Q    + A+E+GV++G ++F+  F L D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   --NASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKG  121
              + + +  DGD + +GD++  I GS RS+L  ER+ALNF+Q+ SGIA++T+ YV  + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEAL  181
             + ++ DTRKTTP LR++E+ AVR GGG+NHR  LSDA+M+KDNH+AA++S   +I++A 
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-  190

Query  182  LNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEAS  241
               +A  P    VEVEV+ +   E   AAGVD IMLDN +++Q+ +++ LI+GR+ +E S
Sbjct  191  ---RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  242  GGVNLNTVGKIASTGVDVISVGALTHSVHALDLGL  276
            G +++ T++++ + ++D +S G+LTHS  +LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

204) DP1795 in NC_006138


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (635),  Expect = 3e-44, Method: Compositional matrix adjust.
 Identities = 119/280 (43%), Positives = 189/280 (68%), Gaps = 11/280 (3%)

Query  4    NTLRSTLLNFLAEDIGRGDITSESIFPAKQQGKAHLVARQPMvvagadavagevFRVQND  63
            +TL+++L     ED+   D ++++IF    Q+K  L A+++  V ++ +V   VF + + 
Sbjct  15   DTLKAAL----REDVHSEDYSTNAIFDHHGQAKVSLFAKEA-GVLAGLTVFQRVFTLFDA  69

Query  64   SILVENA--IADGTHIEKGDIILTVSGPVVDLLKAERVALNLLQRLSAIATMTSLFVQAV  121
             +  +N+  + DG ++  GD++L + G+V  LL  ERVALN+LQ+LS+IA+MT+ +V+A+
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  122  EGTGVRITDTRKTTPGLRMLEKYAVLAGGGSNHRFNLADGVMIKDNHIAACGSLTAAVER  181
             +  +++ DTRKTTP LR++EKYAV  GGG NHRFNL+D++M+KDNHIAA GS+  A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  182  ARLAIPHTIKIEVETDTLPQVEECVACGADIIMLDNMSLADMKTAVAMIDGRALVEASGG  241
            AR   P    +EVE ++L+  EE  A G DIIMLDNMSL ++  A+++I GR+ +E SG 
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  242  VTLKTVADIATTGVDIISSGALTHSVISCDIGMDWSMENL  281
            + + T++ +   ++D +SSG+LTHS  S    +D SM  L
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKS----LDFSMKGL  285

205) nadC in NC_016642


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  172 bits (635),  Expect = 3e-44, Method: Compositional matrix adjust.
 Identities = 122/284 (43%), Positives = 189/284 (67%), Gaps = 4/284 (1%)

Query  1    MSVSSLPELSLIMVDDAVKAALLEDFGRAGDITSQATIPAEAMATGVIAARKDGVLAGID  60
            MS+ S  +L+ + +DD++KAAL ED  ++ D +++A +  ++ A   + A+  GVLAG+ 
Sbjct  1    MSIIS-TDLTPFQIDDTLKAALRED-VHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLT  58

Query  61   LALSAFRQVDPNLNVTVLAQ--DGDKLAPGTIIARIHGPARALLTAERVALNFLSHLSGI  118
            +    F   D+++      Q  DGD+L++G ++  I G+ R+LLT ERVALNFL HLSGI
Sbjct  59   VFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGI  118

Query  119  ATATNAFQRKISHTNATIVCTRKTTPGLRSFEKYAVRCGGGMNHRFGLDDAILIKDNHIA  178
            A+ T A+   +++    +  TRKTTP LR FEKYAVR GGG NHRF L DAI++KDNHIA
Sbjct  119  ASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIA  178

Query  179  VAGGVIPAIERARAFAGHLVRIEVEVDTLEQLKEALTAKPDVVMLDNMGPDLLKQAVEIN  238
              G+V  AI +ARA+A  +  +EVEV++L    EA +A  D++MLDNM+ + + QA+ + 
Sbjct  179  AVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI  238

Query  239  NGQAVLEASGTVTLSTVQEIAEAGVDIISSGWITHSAPILDLGL  282
             G++ +E SG + ++T+  +   ++D +SSG +THSA  LD+++
Sbjct  239  AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

206) nadC in NC_017912


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (634),  Expect = 3e-44, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 188/272 (70%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEAVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKGDVLAEMEGQAAALLTGERVILNLLQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+  GD++ E+ G   +LLT ERV LN+LQ++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKICDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIKAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  272
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

207) BSn5_04740 in NC_014976


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (634),  Expect = 3e-44, Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 184/260 (71%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDENV--QIILHKKDG  72
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D +V  Q   + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEGQLREAIAAGADVIMFDNCPPDTVRHFAKLTPAHIKTEASGGITLESLPAFKGTG  252
            E+E+ +   EA AAG D+IM+DN + + + +   L +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

208) Cyast_1448 in NC_019778


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (634),  Expect = 3e-44, Method: Compositional matrix adjust.
 Identities = 119/271 (44%), Positives = 181/271 (67%), Gaps = 6/271 (2%)

Query  14   LKGWLLEDIGRGDRTTEAIFPLGSSTGKAHWLLKEDGVIAGLPIAKQVFQLLDEKIVFLD  73
            LK+ L ED+   D +T+AIF    + +K   + KE GV+AGL + ++VF L+D  + F +
Sbjct  17   LKAALREDVHSEDYSTNAIFD-HHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  74   --KITEGDSCISGTILVEIEGSKDALLTGERVALNLVMHLSGIATMTRKYVEAIADYPTQ  131
              ++ +GD   SG +++EI GS  +LLT ERVALN++ HLSGIA+MT  YVEA++D   +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  132  LVDTRKTTPGLRILEKYATQVGGAVNHRMGLDDAVMIKDNHIEAAGSIARAIALIRDKIP  191
            + DTRKTTP LR++EKYA +VGG+ NHR  L DA+M+KDNHI A GS+ +AIA  R   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  192  YPLTIEVETNNLAQVQEAIEHQADIIMLDNMAIPTMKEAVKIIQQAHKKIKSEASGNVTL  251
            +   +EVE ++LA  +EA     DIIMLDNM++  + +A+ +I     + + E SGN+ +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG---RSRIECSGNIDM  252

Query  252  DNIAQIAETGVDFISTSATITRAPWLDLSMK  282
              I+++   ++D++S+++    A  LD+SMK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

209) nadC in NC_017195


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (633),  Expect = 4e-44, Method: Compositional matrix adjust.
 Identities = 118/260 (46%), Positives = 183/260 (71%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAVIKEGFALLDENV--QIILHKKDG  72
            ED+ + D ++++IF++++     + AK  G++AG +V++  F+L+D +V  Q   + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPDHIKTEASGGITLESLPAFKGTG  252
            E+E+     EA AAG D+IM+DN + + + +   L +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

210) A7A1_0427 in NC_019896


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (634),  Expect = 4e-44, Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 184/260 (71%), Gaps = 3/260 (1%)

Query  34   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDENV--QIILHKKDG  90
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D +V  Q   + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  91   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  150
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  151  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  210
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  211  EIETEGQLREAIAAGADVIMFDNCPPDTVRHFAKLTPAHIKTEASGGITLESLPAFKGTG  270
            E+E+ +   EA AAG D+IM+DN + + + +   L +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  271  VNYISLGFLTHSVKSLDISM  290
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

211) Calkro_1486 in NC_014720


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (632),  Expect = 4e-44, Method: Compositional matrix adjust.
 Identities = 119/270 (45%), Positives = 186/270 (69%), Gaps = 2/270 (0%)

Query  7    IDKIIRDALIEDMPYGDITTDLLIPQESTSSAVLLAKESGILCGIDVAKRVFEILDSNIK  66
            ID  ++ AL ED+   D +T+ ++ +++ +   L+AKE+G+L G+ V +RVF ++D+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLK--TDGDNIQKGDVLAKIQGKTRTILMGERLALNILQRMSGIATFTNMLVQKVKGY  124
            F++     DGD +  GD++  I G  R++L  ER+ALN+LQ++SGIA+ T   V+ + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  RAAVSDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKAVGSITEAVKRAKE  184
            R  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI AVGS+  A+ +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NVPHTMKVEVEVRNMQEFEEALAAGADIIMLDHFTVDEMKRAVEKAEGRVLIEASGNINI  244
              P    VEVEV ++   EEA AAG DIIMLD+ +++++ +A+    GR  IE SGNI++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DNIEEIAKTGVDIISVGSITHSVKSLDISL  274
              I  +   ++D +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

212) Riv7116_5264 in NC_019678


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (633),  Expect = 4e-44, Method: Compositional matrix adjust.
 Identities = 123/288 (43%), Positives = 181/288 (63%), Gaps = 7/288 (2%)

Query  1    METTTAVLPPFIILDSHLEEWLREDIGRGDRTTQCLLNQDEAEGKARWIAKADGVVAGLP  60
            M   ++ L PF I D  L   LRED+   D +T+ +++++ +++K   +AK  GV+AGL 
Sbjct  1    MSIISTDLTPFQI-DDTLKAALREDVHSEDYSTNAIFDHH-GQAKVSLFAKEAGVLAGLT  58

Query  61   VAARVFQLLNKKVDFTA--LVKEGEFCEQGKVIAQIKGSLDALLTGERVALNLAMSLSGI  118
            V  RVF L++  V F      K+G+    G ++ +I GS+ +LLT ERVALN+   LSGI
Sbjct  59   VFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGI  118

Query  119  ATLTRKYVEKIEDLPTLFVDTRKTTPGLRILEKYATQVGGAINHRMGLDDAVMIKDNHIA  178
            A++T  YVE + D      DTRKTTP LR++EKYA +VGG+ NHR  L DA+M+KDNHIA
Sbjct  119  ASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIA  178

Query  179  AAGGIGKAVNKIRSRIPYPLTIEVETENLEQVKEVLEYQADIIMLDNMKLDMMRQAVEVI  238
            A G++ KA+ + R+  P+   +EVE E+L    E      DIIMLDNM L+ + QA+ +I
Sbjct  179  AVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI  238

Query  239  RQHNNKVKIEASGNVMLETIRAIAETGVDYISSSAPITQSKWLDLSMK  286
                 + +IE SGN+ + TI  +   ++DY+SS++    +K LD+SMK
Sbjct  239  ---AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

213) nadC in NC_010645


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (633),  Expect = 4e-44, Method: Compositional matrix adjust.
 Identities = 118/282 (42%), Positives = 190/282 (68%), Gaps = 3/282 (1%)

Query  17   VVPALPQVMLEPLVRAALLEDLGRAGDITSDAIVPAEARGQTRLVARQAGVLAGLDLARL  76
            +   L    ++  ++AAL ED+ ++ D +++AI   +++++  L A++AGVLAGL + + 
Sbjct  4    ISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  77   AFRLIDPEIRFQA--RLTDGARLEPGSEIARIEGSARGMLTAERTALNFLGHLSGVATGT  134
             F L+D+E+ FQ   ++ DG RL +G  +  I GS R++LT ER ALNFL HLSG+A+ T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  135  ASIADAIAHTACKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHIAFAGG  194
            A+  +A+++   KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNHIA  G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  195  VTQALARARASVGHMVKIELEVDTLDQLDEALASGVDVVLLDNMDHDTLREAVRRVDGRA  254
            V +A+A+ARA    +  +E+EV++L   +EA A+GVD+++LDNM  + + +A+  + GR+
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  255  ITEASGRiapetaaaiaetGVDLMAVGWLTHSARVLDIGLDS  296
              E SG I   T + +   ++D ++ G LTHSA+ LD+++ +
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

214) nadC in NC_017061


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (632),  Expect = 5e-44, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 188/272 (70%), Gaps = 3/272 (1%)

Query  28   LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEAVIREGWKLLHDD  86
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  87   IRIRSLK--KDGERMKKGDVLAEMEGQAAALLTGERVILNLLQRMSGIATMTDEAKRRLD  144
            + +++    KDG+R+  GD++ E+ G   +LLT ERV LN+LQ++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  145  DPSIKICDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIKAAMERA  204
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  205  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI  264
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  265  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  296
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

215) nadC in NC_017196


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  171 bits (631),  Expect = 6e-44, Method: Compositional matrix adjust.
 Identities = 116/260 (45%), Positives = 183/260 (71%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDENVRIILHK--KDG  72
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D +V +      KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEGQLREAIAAGADVIMFDNCPPDTVRHFAKLTPDHIKTEASGGITLESLPAFKGTG  252
            E+E+ +   EA AAG D+IM+DN + + + +   L +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

216) nadC in NC_009725


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (628),  Expect = 1e-43, Method: Compositional matrix adjust.
 Identities = 120/272 (45%), Positives = 188/272 (70%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDVTSQAIFSDQ-QCKARIITKTDGVFAGEAVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  +++K  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKGDVLAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+  GD++ EI G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIRAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  272
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

217) GYMC10_0058 in NC_013406


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (628),  Expect = 1e-43, Method: Compositional matrix adjust.
 Identities = 121/271 (45%), Positives = 186/271 (69%), Gaps = 5/271 (1%)

Query  12   QSIRTWLQEDIGSGDITTLTTIEPGHESKGVIHAKEAGIVAGMPVAELVFETVDPTLMFT  71
            +++++ L+ED+ S D +T + ++   ++K  + AKEAG++AG+ V + VF   D+ + F 
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  72   A--LVRDGDVVEKGTVLAEVEGSTHRILTGERLALNLLQRLSGIATKTRSFVDVLEGLPT  129
                 +DGD +  G ++ E+ GS + +LT ER+ALN+LQ+LSGIA+ T ++V+ L +   
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  130  RLVDTRKTTPGHRMLEKYAVRVGGGANHRFGLYDAVMIKDNHIKGAGGIAQAVSRARAHI  189
            ++ DTRKTTP  R++EKYAVRVGGG NHRF L DA+M+KDNHI + G++ +A+++ARA  
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  190  PHTMTIEVETESLAQVEEALAAGADIIMLDNMSHDMMTEAVRRIKAKSPHVRVEASGNVT  249
            P    +EVE ESLA  EEA AAG DIIMLDNMS + + +A+  I ++S   R+E SGN+ 
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGNID  251

Query  250  LETVRGIAETGVDVISVGRLTYSFHSLDISL  280
            + T+  +   ++D +S G LT S  SLD+S+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

218) Calhy_1511 in NC_014652


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (627),  Expect = 1e-43, Method: Compositional matrix adjust.
 Identities = 118/270 (44%), Positives = 183/270 (68%), Gaps = 2/270 (0%)

Query  7    IDKIIKDALVEDMPYGDITTDLLIPQESTSSAVLLAKENGILCGIDVAKRVFEILDGSIK  66
            ID  +K AL ED+   D +T+ ++ +++ +   L+AKE G+L G+ V +RVF ++D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLK--TDGDNIQKGDVLAKIQGKTRAILMGERLALNLLQRMSGIATFTNMLAQKIKGY  124
            F++     DGD +  GD++  I G  R++L  ER+ALN+LQ++SGIA+ T    + + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  RATVTDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKAVGSITEAVKRAKE  184
            R  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI AVGS+  A+ +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NVPHTMKVEVEVRNMQEFEEALASGADIIMLDHFTVDEMKKAVEKAEGRVLIEASGNINI  244
              P    VEVEV ++   EEA A+G DIIMLD+ +++++ +A+    GR  IE SGNI++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DNIEEIAKTGVDIISVGSITHSVKSLDISL  274
              I  +   ++D +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

219) B938_12875 in NC_019842


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (630),  Expect = 7e-44, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 188/272 (70%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEAVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKGDVLAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+  GD++ EI G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPTIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIRAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVGRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  272
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

220) Athe_1214 in NC_012034


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (630),  Expect = 7e-44, Method: Compositional matrix adjust.
 Identities = 119/270 (45%), Positives = 186/270 (69%), Gaps = 2/270 (0%)

Query  7    IDKIIRDALIEDMPYGDITTDLLIPQESTSSAVLLAKESGILCGIDVAKRVFEILDSNIK  66
            ID  ++ AL ED+   D +T+ ++ +++ +   L+AKE+G+L G+ V +RVF ++D+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLK--TDGDNIQKGDVLAKIQGKTRAILMGERLALNILQRMSGIATFTNMLVQKVKGY  124
            F++     DGD +  GD++  I G  R++L  ER+ALN+LQ++SGIA+ T   V+ + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  RAAVTDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKAVGSITEAVKRAKE  184
            R  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI AVGS+  A+ +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NVPHTMKVEVEVRNMQEFEEALAAGADIIMLDHFTVDEMKMAVEKAEGRVLIEASGNINI  244
              P    VEVEV ++   EEA AAG DIIMLD+ +++++  A+    GR  IE SGNI++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DSIEEIAKTGVDIISVGSITHSVKSLDISL  274
             +I  +   ++D +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

221) nadC in NC_007503


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (629),  Expect = 7e-44, Method: Compositional matrix adjust.
 Identities = 121/273 (45%), Positives = 186/273 (69%), Gaps = 2/273 (0%)

Query  3    PFYVREHIRLALEEDIGMGDITTEAIAVGDEHTVGFVKVKEPGVVAGLFVLEEIYRVLSG  62
            PF + + ++ AL ED+   D +T+AI   + ++   +  KE+GV+AGL V++ ++ ++ +
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  63   NVRVE--YMVKDGEEVASGQVIAKIYGPAAVILMGERVALNYLQFLSGIATKTRRIINKV  120
            +V  +     KDG+ ++SG+++  I G+   +L  ERVALN+LQ LSGIA+ T   ++ +
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  121  KDYPVRVVDTRKTVPGLRWLSKYAVRVGGGHNHRFNLSDGILLKDNHIKAAGGIEEAIKR  180
             D  ++V DTRKT P LR + KYAVRVGGG NHRFNLSD+I+LKDNHI A G+++ AI +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  181  ARKYAPHTLKIEIEVESLEGLKEAIAAGADIVMLDNMSPQRVKEARKIAGDKVLLEASGG  240
            AR YAP    +E+EVESL +  EA AAG DI+MLDNMS +++ +A  + +++  +E SG 
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  241  INEENILEYARAGIDVISLGTLTHSVKALDISL  273
            I+   I  +   +ID +S G+LTHS K+LD+S+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

222) Sgly_0223 in NC_015172


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (630),  Expect = 7e-44, Method: Compositional matrix adjust.
 Identities = 121/270 (45%), Positives = 188/270 (70%), Gaps = 5/270 (1%)

Query  5    EEIIDRALKEDIGTGDLSSQIIPEDYLGMARI--YAKEHGVVCGLQIAEAVFKRVDPDIT  62
            ++ +  AL+ED+ + D S++ I ++  G A++  +AKE GV+ GL + + VF   D+++T
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHH-GQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  63   IE--FKIKDGDLFKAGDLIMSIQGPLGSILQAERTALNFLQHLSGISSYTRLLVDKVSDL  120
            ++   ++KDGD + +GDL++ I G++ S+L  ER ALNFLQHLSGI+S T   V+ ++D 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  121  GVKVVDTRKTIPGMRVLQKYAIRVGGGQNHRLGLYDAVMLKDNHHAAVGGLEEAISRVKA  180
             +KV DTRKT P +R+++KYA+RVGGG NHR+ L DA+MLKDNH AAVG+++ AI++ +A
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  181  KIGHMVKIEVECETLEQVEQSVNSGVDVIMLDNMNIEEMKTAVRSIAGRAITEASGGITE  240
                +  +EVE E+L   E++  +GVD+IMLDNM++E++  A+  IAGR+  E SG I  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  241  ENIREIAETGVDVVSVGKLTNYVKALDFSL  270
              I  +   ++D VS G LT+  K+LDFS+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

223) Ppro_0653 in NC_008609


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (629),  Expect = 8e-44, Method: Compositional matrix adjust.
 Identities = 121/267 (46%), Positives = 187/267 (71%), Gaps = 3/267 (1%)

Query  8    IDAALAEDIHTGDITTRALLPKKRPATARLVAKEDFVLAGISVAERVFDRLGGSPVDFAA  67
            + AAL ED+H+ D +T A++     A   L AKE  VLAG++V +RVF  L ++ V F  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT-LFDAEVTFQN  75

Query  68   RAV--DGELIASGSVFATLEGDAADLLMGERVALNLLQRMCGVATITSHFVQAVRGTRTR  125
                 DG+ ++SG +   + G    LL  ERVALN+LQ++ G+A++T+ +V+A+ + R +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  126  IVDTRKTTPGLRELEKYAVRVGGGFNHRTGLYDGVLIKENHiaaaggigeaisraraYIP  185
            + DTRKTTP LR +EKYAVRVGGG+NHR  L D++++K+NHIAA G++  AI++ARAY P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  186  HTLKIEIETETLAQVEEALTAGADVIMLDNMTLDDMRAAVSLVSGRVPLEASGGVSLDTV  245
                +E+E E+LA  EEA +AG D+IMLDNM+L+++  A++L++GR  +E SG + + T+
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  246  RAIAETGVDIISVGALTHSARAMDISM  272
              +   ++D +S G+LTHSA+++D+SM
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

224) nadC in NC_022081


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (629),  Expect = 8e-44, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 188/272 (70%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEAVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKGDVLAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+  GD++ EI G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIRAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  272
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

225) Csac_1779 in NC_009437


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (629),  Expect = 8e-44, Method: Compositional matrix adjust.
 Identities = 114/266 (43%), Positives = 184/266 (70%), Gaps = 2/266 (0%)

Query  11   IKEALIEDMPYGDITTDLLIPQDSISSAILIAKEDGILCGIDVAKRVFEILDENIEFEKI  70
            +K AL ED+   D +T+ ++ +++ +   L+AKE G+L G+ V +RVF ++D ++ F++ 
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  71   KS--DGEPIKKGDILAKIKGNTRAILKGERLALNLLQRMSGVATVTNRLSQKIKGYRAIV  128
                DG+ +  GD++  I G+ R++L  ER+ALN+LQ++SG+A++T    + + + R  V
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  129  TDTRKTVPLLRMLDKYGVFVGGGKNHRYSLSDAVLIKDNHIKAVGSIKEAIKRARENIPH  188
             DTRKT P LR+++KY+V VGGG NHR++LSDA+++KDNHI AVGS++ AI +AR   P 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  189  TMKIEVEVRTMNEFEEALEAGADIIMLDHFGLDDMKKAVEAASGKALIEASGNITLENIE  248
               +EVEV ++   EEA  AG DIIMLD+ +L+++ +A+   +G++ IE SGNI +  I 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  249  EIAKTGVDIISVGSITHSVKSLDISL  274
             +   ++D +S GS+THS KSLD+S+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSM  282

226) HPL003_07785 in NC_016641


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (630),  Expect = 8e-44, Method: Compositional matrix adjust.
 Identities = 114/274 (42%), Positives = 184/274 (68%), Gaps = 5/274 (1%)

Query  17   ELTAQIRSWLREDTGSGDVTTRWTIEPNHQSKAVIHAKESGVAAGLPVAELVFRVVDPSL  76
            ++   +++ LRED  S D +T   ++ + Q+K  + AKE+GV AGL V + VF + D+ +
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  77   SF--TPLVTDGQWIEQGTVLAEVTGSTHAILTGERLALNLIQRMSGIATRTKSFVDQLHG  134
            +F       DG+++  G ++ E+ GS +++LT ER+ALN++Q++SGIA+ T ++V+ L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  135  LSTRLVDTRKTTPGHRLLEKYAVRVGGGSNHRFGLYDAVMIKDNHIKGAGGIMQAVTRAR  194
               ++ DTRKTTP  RL+EKYAVRVGGG NHRF L DA+M+KDNHI + G++ +A+++AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  195  THIPHTMTIEVETENMEQIQEALNAGADIIMLDNMSVKDMKEAVRFIREQAPHVKTEASG  254
            +  P    +EVE E++   +EA  AG DIIMLDNMS+ ++ +A+ +I   A + + E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSG  248

Query  255  NVSLETVRAMAESGVDVISVGRLTYSFHNLDISL  288
            N+ + T+      ++D +S G LT S  +LD+S+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

227) nadC in NC_020410


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (628),  Expect = 9e-44, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 188/272 (70%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEAVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKGDVLAEMEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+  GD++ E+ G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIKAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLGTLPAFKGTGVQYISLGFLTHSVKSADISM  272
             + T++ F+G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

228) nadC in NC_015717


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  170 bits (629),  Expect = 9e-44, Method: Compositional matrix adjust.
 Identities = 108/256 (43%), Positives = 172/256 (68%), Gaps = 2/256 (0%)

Query  23   SGDITTNATVGADVRADALLVARMPGVVAGIALAEAAFRELDPDCSFEV--DIDDGASIV  80
            S D +TNA  + + +A   L A+ +GV+AG+++ +  F  +D++ +F+   ++ DG  + 
Sbjct  27   SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLT  86

Query  81   ADDTVARISGNARAILTAERVALNFMGRMCGIATLTRRYVEATAGTKAKIVDTRKTMPGL  140
            ++D V  I G+ R++LT ERVALNF+ ++ GIA++T  YVEA ++ + K+ DTRKT P L
Sbjct  87   SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNL  146

Query  141  RVFEKYAVRCGGGHNHRFGLFDAILIKDNHIVAAGGVSEAIKAARNAAGHMTKIEVEVDT  200
            R+FEKYAVR GGG NHRF L DAI++KDNHI A G+V  AI  AR  A  +  +EVEV++
Sbjct  147  RLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVES  206

Query  201  LDQLDVVMREKVDCVLLDNMNPQELRTAVATVAGRCLTEASGGVNLDTVKEIAASGVDLI  260
            L   +      VD ++LDNM+ +++  A++ +AGR   E SG +++ T+  + + ++D +
Sbjct  207  LAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYV  266

Query  261  SVGALTHSAPVLDLGL  276
            S G+LTHSA  LD+++
Sbjct  267  SSGSLTHSAKSLDFSM  282

229) nadC in NC_013939


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (626),  Expect = 1e-43, Method: Compositional matrix adjust.
 Identities = 118/271 (44%), Positives = 181/271 (67%), Gaps = 2/271 (0%)

Query  7    LNKIIDLALLEDIGSGDLTTKSISPYLKKSKYYLIAKESFILCGMPVVNEIF--YKTDRN  64
            ++  +  AL ED+ S D +T++I     ++K  L+AKE+ +L G+ V + +F  + ++  
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  65   IKINFLKNDGELVNAGDKLAEIIGDTAIILMLERTVLNFLQRLSGIATNTNKYIKELDGT  124
            ++     +DG+ + +GD + EIIG    +L  ER  LNFLQ+LSGIA+ T  Y+  L++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  NIKILDTRKTTPGLRILEKYAVKIGGGTNHRIGLFDGVMLKDTHIDAVGSIKKAVELVRS  184
             IK++DTRKTTP LR++EKYAV++GGG NHR+ L D++MLKD HI AVGS++KA+   R+
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NIPVTVKIEVETRNLKEVEEAVEAGADIIMLDNFDINSINEACQLINKRAKIEVSGGITL  244
              P    +EVE  +L   EEA  AG DIIMLDN  ++ I++A  LI  R++IE SG I +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DKLHMYKKYPIDFISVGALTNSFKSVDISMK  275
              +  ++  +ID++S G+LT+S KS+D+SMK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

230) KSO_006605 in NC_020272


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (624),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 186/272 (69%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEDVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG  V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRPLK--KDGERMKKGDVLAEMEGRAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + ++     KDG+R+  GD++ E+ G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIKAAVERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADIIMFDNCPPESVRRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG DIIM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  272
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

231) I653_13270 in NC_020832


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (625),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 115/260 (45%), Positives = 181/260 (70%), Gaps = 3/260 (1%)

Query  16   EDIGTGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAIIKEGFSLLDESV--RTILRKSDG  72
            ED+ + D ++++IF++++     + AK  G++AG ++++  F+L+D  V  +   +  DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLHKGEVIAELQGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKT  132
            D L  G+++ E+ G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMANIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+  A  +AR  A  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPDHIKTEASGGITLESLPAFKGTG  252
            E+E+     EA AAG D+IM+DN + + + +   L +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

232) Slip_0141 in NC_014220


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (624),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 117/270 (44%), Positives = 184/270 (69%), Gaps = 2/270 (0%)

Query  14   LNDVIRRALEEDIGYRDLTTDSIISREHRSRAVIIAKQEGIIAGLEVARRTFHLLDPAID  73
            ++D ++ AL ED+   D +T++I+ ++ +++  ++AK+ G++AGL V +R F L+D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  74   FQKAVE--DGERVEPREVVARLEGCTRAILQGERVALNFLQRMSGIATYTRSLCELIQGT  131
            FQ++ +  DG+R+ + ++V  + G  R++L  ERVALNFLQ++SGIA+ T +  E + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  132  KADLVDTRKTTPGLRVLEKYAVRVGGGKNHRFGLFDGVIIKDNHIVAAGSITAAVKAVRD  191
            +  + DTRKTTP LR++EKYAVRVGGG NHRF L D++++KDNHI A GS+  A+   R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  192  KIPHTVRVEVEVQNlemleealeagaDIVMLDNMDIETMRQAVERASNRVLLEASGGINE  251
              P    VEVEV++L   EEA  AG DI+MLDNM +E + QA+   + R  +E SG I+ 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  252  NNIRAVALTGVNFISVGALTHSAPSLDISL  281
              I      +++++S G+LTHSA SLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

233) RBR_10270 in NC_021013


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (624),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 117/277 (43%), Positives = 193/277 (70%), Gaps = 3/277 (1%)

Query  3    LNSIYVDNLIKTALLEDINYLDTTTDYLIDENQENTAIFLAKSSGVLCGIEVALRVFEIL  62
            L ++ +D+ +K+AL ED++  D +T+ ++D++ +    ++AK +GVL G+ V  RVF ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   QPN-GFE-AKVYKHDGDKLVKGEIIAEIHGKTRTILKGERTALNLIQHMSGIATATNKAV  120
            +++  F+ +  +K DGD+L  G+++ EI G  R++L  ER ALN++QH+SGIA+ T   V
Sbjct  68   DAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  121  EIVSGTKASIADTRKTLPGMRPLQKYAVTVGGGRNHRYNLSDAAMLKDNHIDAGGGIANA  180
            E +++ +  + DTRKT P +R ++KYAV VGGG NHR+NLSDA MLKDNHI A G++ +A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  181  VSKLKSKLGHMTKVELEVRNLDELNQALEAGVDVIMLDNMSPELMKQAVDITAGKALLEA  240
            +++ ++    +  VE+EV +L   ++A  AGVD+IMLDNMS E + QA+ + AG++ +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  241  SGGITDETLREIAETGVDIISMGALTHSVKAFDISLK  277
            SG I   T+  +   ++D +S G+LTHS K++D+S+K
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

234) nadC in NC_017448


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (624),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 117/281 (42%), Positives = 188/281 (67%), Gaps = 12/281 (4%)

Query  10   FPTEDALTMIRLALAEDVRTGDVTSEWTIPADQKQHARLIAKEDGVLAGLPIIELVFQEL  69
            F  +D+L   + AL EDV++ D +++  +  + +    L+AKE GVLAGL +++ VF  +
Sbjct  11   FQIDDTL---KAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  70   KANAKVTLHK----NDGDVVKKGDLIAELDGTTHELLTGERTLLNFIQQLSGVATVAHTF  125
              +A VT+++    +DGD +  GDL+ E+ G+ + LLT ER  LNF+Q+LSG+A+++ ++
Sbjct  68   --DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  126  QEALKGGKTKVLDTRKTIPGFRTLQKYAVRVGGGSNHRMGLFDMVLVKDNHIAAAGGVLE  185
             EAL +++ KV+DTRKT P +R ++KYAVRVGGG NHR  L D +++KDNHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  186  ALEVVKKNNKQGLMVEMEVENFDQLRALLNKGVDVIMLDNMSNEMMAEALKIIKESGDKC  245
            A+   +       MVE+EVE++         GVD+IMLDNMS E + +A+ +I   +++ 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  246  LVEGSGNMTLERAKQIATLGLDFISVGALTHSVKALDISMR  286
             +E SGN+ +    ++  L++D++S G+LTHS K+LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

235) Fisuc_2255 in NC_013410


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  169 bits (624),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 117/281 (42%), Positives = 188/281 (67%), Gaps = 12/281 (4%)

Query  10   FPTEDALTMIRLALAEDVRTGDVTSEWTIPADQKQHARLIAKEDGVLAGLPIIELVFQEL  69
            F  +D+L   + AL EDV++ D +++  +  + +    L+AKE GVLAGL +++ VF  +
Sbjct  11   FQIDDTL---KAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  70   KANAKVTLHK----NDGDVVKKGDLIAELDGTTHELLTGERTLLNFIQQLSGVATVAHTF  125
              +A VT+++    +DGD +  GDL+ E+ G+ + LLT ER  LNF+Q+LSG+A+++ ++
Sbjct  68   --DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  126  QEALKGGKTKVLDTRKTIPGFRTLQKYAVRVGGGSNHRMGLFDMVLVKDNHIAAAGGVLE  185
             EAL +++ KV+DTRKT P +R ++KYAVRVGGG NHR  L D +++KDNHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  186  ALEVVKKNNKQGLMVEMEVENFDQLRALLNKGVDVIMLDNMSNEMMAEALKIIKESGDKC  245
            A+   +       MVE+EVE++         GVD+IMLDNMS E + +A+ +I   +++ 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  246  LVEGSGNMTLERAKQIATLGLDFISVGALTHSVKALDISMR  286
             +E SGN+ +    ++  L++D++S G+LTHS K+LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

236) nadC in NC_016784


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (623),  Expect = 3e-43, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 186/272 (69%), Gaps = 3/272 (1%)

Query  28   LQLKQMLTHFFQEDIGTGDATSQAIFSDQ-QCKARIIAKTDGVFAGEDVIREGWKLLHDD  86
            +Q+ + L   ++ED+ + D +++AIF ++ Q K  ++AK  GV+AG  V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  87   IRIRPLK--KDGERMKRGDVLAEMEGRAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  144
            + ++     KDG+R+  GD++ E+ G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  145  DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIKAAVERA  204
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  205  RKTAGQMLAVEVEIESEQQLLEAIEAGADIIMFDNCPPESVRRFAGMTPGHIKTEASGGI  264
            R  A  +  VEVE+ES     EA  AG DIIM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  265  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  296
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

237) nadC in NC_022075


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (621),  Expect = 3e-43, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 187/272 (69%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTHFFQEDIGTGDATSQAIFSYQ-QCKARIIAKTDGVFAGEAVIREGWKLLHDD  62
            +Q+ + L   ++ED+ + D +++AIF  + Q K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKGDVLAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+  GD++ EI G   +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPTIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIRAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVRVGGG+NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI  240
            R  A  +  VEVE+ES     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPAYKGTGVQYISLGFLTHSVKSADISM  272
             + T++ ++G +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

238) Cri9333_4696 in NC_019753


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (623),  Expect = 3e-43, Method: Compositional matrix adjust.
 Identities = 119/268 (45%), Positives = 181/268 (68%), Gaps = 7/268 (2%)

Query  12   LPPWIVLDPLLHNWLLEDIGRGDRTTQGLLGWESSSGQASWTAKEVGVIAGLPLAGRVFQ  71
            L P  + D  L   L ED+   D +T+++++ ++ + + S  AKE GV+AGL +  RVF 
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQA-KVSLFAKEAGVLAGLTVFQRVFT  65

Query  72   LLNSDVSFVAVAA--EGEVCQRGQVVAQMQGSLSALLTGERVALNLAMRLSGIATLTRKY  129
            L++++V+F       +G+    G++V ++ GS+ +LLT ERVALN+  +LSGIA++T  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  130  VEQIADLPTKLVDTRKTTPGLRLLEKYATQVGGAVNHRMGLDDAVMIKDNHIEAAGGIEK  189
            VE ++D   K+ DTRKTTP LRL+EKYA +VGG+ NHR  L DA+M+KDNHI A G+++K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  190  AITRIRSQMPYPLTIEVETETLAQVKEALQYGADIIMLDNMPVEMMRQAVEIIRDRNNRI  249
            AI++ R+  P+   +EVE E+LA   EA   G DIIMLDNM++E + QA+ +I +R+   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  250  KIEASGNITLETIRAVAETGVDYISSSA  277
            +IE SGNI + TI      ++DY+SS++
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGS  270

239) Cagg_1774 in NC_011831


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (622),  Expect = 3e-43, Method: Compositional matrix adjust.
 Identities = 116/275 (43%), Positives = 188/275 (69%), Gaps = 8/275 (2%)

Query  8    IDTIVSQALAEDIGNGDITTLAAIPANIATTAYIVTREAGVIAGLPLVEAVFRKLDPTVR  67
            ID  +  AL ED+ + D +T A +  +  +   + ++EAGV+AGL + + VF  +D+ V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   L--TCHITDGTAVSAGTPVATLTGSARTILSGERVALNLLQRLSGIATLTAQYVAAVAGT  125
            +    ++ DG  +++G  V  + GS R++L+ ERVALN+LQ+LSGIA++TA YV A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  126  RAQIIDTRKTTPGLRVLEKYAVRMGGGRNHRFGLYDGVMLKDNHLAILAAHGVDLATAIA  185
            R +++DTRKTTP LR++EKYAVR+GGG NHRF L D++MLKDNH+A +++    +  AIA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS----VQKAIA  188

Query  186  RVRAQIGPMVRLevevecv-adaivaaeagaDLILLDNMPLDQLRAAVDAVGGRAQTEAS  244
            + RA  +P V++        A A  AA AG D+I+LDNM+L+Q+  A+  ++GR++ E S
Sbjct  189  QARA-YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  245  GGVTLQTVRAIAETGVDYISVGALTHSVRALDIGL  279
            G + + T+  +   ++DY+S G+LTHS ++LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

240) nadC in NC_010296


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (623),  Expect = 3e-43, Method: Compositional matrix adjust.
 Identities = 114/267 (43%), Positives = 174/267 (66%), Gaps = 6/267 (2%)

Query  16   LREDLGRGDRTTQAIFFGHAKIGQASWIAKEAGVIAGLPVAERVFQLLNPTIHF--TPTV  73
            LRED+   D +T+AIF +H   ++ S +AKEAGV+AGL V +RVF L+++ + F      
Sbjct  21   LREDVHSEDYSTNAIF-DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  74   AEGEFCPKSKVIAEIEGSLDALLIGERVALNLAMRLSGIASATRQYVQKIADLSTRLVDT  133
             +G+    + ++ EI GS+ +LL  ERVALN+  +LSGIAS T  YV+ ++D   ++ DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  134  RKTTPGLRILEKYASGIGGAINHRLGLDDAIMIKDNHIQAAGSIEEAVRRVRQNMPYPLT  193
            RKTTP LR++EKYA  +GG+ NHR+ L DAIM+KDNHI A GS++ A+ + R   P+   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  194  IEVETSQLEEVNQALQQQVEIIMLDNMDLEMMQTAVEMIRNFNSKTKIEASGNITLDRIR  253
            +EVE   L   ++A    V+IIMLDNM LE ++ A+ +I    ++++IE SGNI +  I 
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTIS  256

Query  254  NVAETGVDYISTSAPITRSTWLDISMR  280
                 ++DY+S+++    +  LD+SM+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

241) nadC in NC_014479


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (620),  Expect = 4e-43, Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 180/260 (70%), Gaps = 3/260 (1%)

Query  16   EDIGMGDLTSQSIFGEQS-CEAEIVAKSDGIFAGASVIKEGFALLDENV--QIILHKTDG  72
            ED+   D ++++IF++++     + AK  G++AG +V++  F+L+D +V  Q   +  DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DMLRKGEVIAVLRGPAAALLSGERVVLNLIQRLSGIATMTREAVRRLDDEQIKICDTRKT  132
            D L  G+++  + G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILKACQKARQAVGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D+IM+KDNHIAA GS+ KA  +AR     +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEEQLREAIEAGADVIMFDNCPPETVRHFATLTPDHIKTEASGGITLKSLPAFKGTG  252
            E+E+     EA  AG D+IM+DN + E + +  TL +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

242) COB47_1342 in NC_014392


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (620),  Expect = 4e-43, Method: Compositional matrix adjust.
 Identities = 117/270 (44%), Positives = 186/270 (69%), Gaps = 2/270 (0%)

Query  7    IDKIIKDALIEDMPYGDITTDLLIPQESTSNAVLLAKENGILCGIDVAKRVFEILDGNIK  66
            ID  +K AL ED+   D +T+ ++ +++ ++  L+AKE G+L G+ V +RVF ++D+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLKA--DGEFINKGDVLAKIDGSTRAILKGERLALNLLQRMSGIATFTNMLAQKIKGY  124
            F++     DG+ +  GD++  I GS R++L  ER+ALN+LQ++SGIA+ T    + + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  KATVTDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKAVGSISEAIKRAKE  184
            +  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI AVGS+  AI +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NVPHTMKVEIEVRNMQEFEEALLSGADIIMLDHFTVDEMRKAVEKAGGRVLIEASGNINI  244
              P    VE+EV ++   EEA  +G DIIMLD+ +++++ +A+   +GR  IE SGNI++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DNIEEIAKTGIDIISVGSITHSVKSLDISL  274
              I  +   +ID +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

243) Bfae_03770 in NC_013172


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (622),  Expect = 4e-43, Method: Compositional matrix adjust.
 Identities = 118/279 (43%), Positives = 183/279 (66%), Gaps = 6/279 (2%)

Query  2    LTRAQIDPVVTAALAEDAPWGDLTGEVFLPAGATATAQLTAREDGVLAGIDVVAAAFRLT  61
            LT  QID  + AAL ED    D + + ++   + A   L A+E GVLAG+ V    F L 
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  62   DPATEL-TAHR-ADGDRFTTGEVLATVTGPARAVLQAERIALNLVQRMSGIATATRAMVD  119
            D+   +  +H+  DGDR+T+G+++  + G+ R++L  ER+ALN++Q++SGIA+ T A V+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  120  AVEGTGARITDTRKTTPGLRALERHAVRCGGGVNHRFSLSDAVMAKDNHLAVLAQQGVDL  179
            A+ +   ++ DTRKTTP LR +E+ AVR GGG NHRF+LSDA+M KDNH+A ++     +
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----SV  183

Query  180  TEAIRRARARLGHTTRLEVEVDRLDQIEPVLAGGVDILMLDNFSLADLAAGVRQVAGRAI  239
              AI +ARA       +EVEV+ L   E   A+GVDI+MLDN SL ++  ++  +AGR+ 
Sbjct  184  QKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  240  VEASGTVTLDTVGDIARTGVDVISSGALTHSARHLDLGL  278
            +E SG + + T++ +   ++D +SSG+LTHSA+ LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

244) Lepto7376_3197 in NC_019683


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (620),  Expect = 4e-43, Method: Compositional matrix adjust.
 Identities = 116/272 (43%), Positives = 172/272 (64%), Gaps = 7/272 (2%)

Query  24   LKQWLQEDLGRGDRTTEALFTNKKIPTGQAQLILKAPGIVAGLPFVERVFQLIGPD--FE  81
            LK  L+ED+   D +T+A+F +     ++  L+ K +G++AGL   +RVF L++++  F+
Sbjct  17   LKAALREDVHSEDYSTNAIFDHH--GQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  82   MQAALAEGKDGQPKTLIATLTAPLDTLLMGERVALNILMRLSGIATETAHYARKIEDLPT  141
                + +G    +  L+  + +++ +LL  ERVALN+L +LSGIA+ TA Y   + D   
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  142  TLVDTRKTTPGLRLLEKYAVRVGGGRNHRYGLDDAMMIKDNHIQAAGGITEAIAAVRANS  201
             + DTRKTTP LRL+EKYAVRVGGG NHR+ L DA+M+KDNHI A G++  AIA  RA +
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  202  PYPLAIEVEAETLEQAIEAVQQGADIVMLDNMSPAKMAEVIPPLREINPRIKLEASGNIT  261
            P+   +EVE E+L  A EA   G DI+MLDNMS  ++ + I     I  R ++E SGNI 
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL---IAGRSRIECSGNID  251

Query  262  LETIRAVAETGIDFISTSATITRAPWLDISMK  293
            + TI      +ID++S+++    A  LD+SMK
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

245) nadC in NC_015635


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  168 bits (620),  Expect = 4e-43, Method: Compositional matrix adjust.
 Identities = 110/266 (42%), Positives = 177/266 (67%), Gaps = 2/266 (0%)

Query  7    QIEAVVTMALAEDAPYGDVTSQTLIPATTTATAELVAREPGVLAGAEVFEVAMTTLDPNV  66
            QI+  +  AL ED    D ++++++     A   L A+E+GVLAG  VF+   T +D++V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  67   KV--TLLATDGDHFDAGQVLARVEGPARAVLQAERVALNLVQRMSGIATQTARYVQAVAG  124
                     DGD++ +G+++  + G+ R++L  ERVALN++Q++SGIA+ TA YV+A+++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  125  TKARVVDTRKTTPGLRALERHAVRCGGGHNHRYSLSDAVMAKDNHLAVVGDIAAAVRRAR  184
             + +V DTRKTTP LR +E+ AVR GGG NHR++LSDA+M KDNH+A VG +  A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  185  AELPHTMHIEVEIDRLDQLDTVLAAGPDTIMLDNFSVDDLVEGVRRIDGRAIVEASGGIT  244
            A  P    +EVE++ L   +   AAG D IMLDN S++++ +++  I GR+ +E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  245  LDAIGPIAQTGVDVISVGALTHSVRA  270
            + +I+ +   ++D +S G+LTHS ++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKS  277

246) cur_0075 in NC_010545


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (616),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 118/284 (42%), Positives = 188/284 (67%), Gaps = 8/284 (2%)

Query  95   LTQDTITTAVRAALAEDAPWGDITSEATIPADarlrtaltarEDGVFAGGQVVRAAFELT  154
            LT   I  +++AAL ED    D +++A +  +++ + +L A+E GV+AG  V +  F L 
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  155  DPAITVTE--LAAEGTRFTAGQQLAVIEGPARGVLTAERIALNFAQRMCAIATLTARYVD  212
            D+ +T  +     +G R+T+G+ +  I G+ R++LT ER+ALNF Q++ +IA++TA YV+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  213  AIAGTNARIVDTRKTTPGLRAFEKHSVRVGGGHNHRYGLSDAVMVKDNHLAALTASLGEG  272
            A+++   ++ DTRKTTP LR FEK +VRVGGG NHR+ LSDA+M+KDNH+AA+      G
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV------G  181

Query  273  SITEALRVVRSRVGHTTHIEVEVDRMDQIEPVLAAGVDSIMLDNFGPTELARAVALIDGR  332
            S+  A+   R+       +EVEV+ +   E   AAGVD IMLDN +  ++ +A++LI GR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  333  AATEASGNVSLETVAALAATGVDVISVGKLTHSAGSLDLGLDAL  376
            +  E SGN+ + T++ + + ++D +S G LTHSA SLD+++ +L
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

247) nadC in NC_020230


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (616),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 118/284 (42%), Positives = 188/284 (67%), Gaps = 8/284 (2%)

Query  95   LTQDTITTAVRAALAEDAPWGDITSEATIPADarlrtaltarEDGVFAGGQVVRAAFELT  154
            LT   I  +++AAL ED    D +++A +  +++ + +L A+E GV+AG  V +  F L 
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  155  DPAITVTE--LAAEGTRFTAGQQLAVIEGPARGVLTAERIALNFAQRMCAIATLTARYVD  212
            D+ +T  +     +G R+T+G+ +  I G+ R++LT ER+ALNF Q++ +IA++TA YV+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  213  AIAGTNARIVDTRKTTPGLRAFEKHSVRVGGGHNHRYGLSDAVMVKDNHLAALTASLGEG  272
            A+++   ++ DTRKTTP LR FEK +VRVGGG NHR+ LSDA+M+KDNH+AA+      G
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV------G  181

Query  273  SITEALRVVRSRVGHTTHIEVEVDRMDQIEPVLAAGVDSIMLDNFGPTELARAVALIDGR  332
            S+  A+   R+       +EVEV+ +   E   AAGVD IMLDN +  ++ +A++LI GR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  333  AATEASGNVSLETVAALAATGVDVISVGKLTHSAGSLDLGLDAL  376
            +  E SGN+ + T++ + + ++D +S G LTHSA SLD+++ +L
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

248) Oant_0431 in NC_009667


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (619),  Expect = 5e-43, Method: Compositional matrix adjust.
 Identities = 112/238 (48%), Positives = 165/238 (70%), Gaps = 3/238 (1%)

Query  44   LFSLRQPGVIAGLDVAEMAFRLVDPDVTFE--RMARDGQSLEKGADVARVSGSSRSILAG  101
            LF+ +++GV+AGL V +  F L D++VTF+  +  +DG+ L  G  V  + GS RS+L+ 
Sbjct  46   LFA-KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTC  104

Query  102  ERTALNFLGHLSGIATATTNLVKAVAGTKASIVCTRKTTPGLRALQKYAVRAGGGMNHRF  161
            ER ALNFL HLSGIA+ T+  V A+++ +  +  TRKTTP LR ++KYAVR GGG NHRF
Sbjct  105  ERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRF  164

Query  162  ALYDAVLIKDNHIAVAGGVREAIERAKAGAGHMVKIEVEVDTLRQLEEAMAIGVDAVLLD  221
             L DA+++KDNHIA  G+V+ AI +A+A A  +  +EVEV++L   EEA A GVD ++LD
Sbjct  165  NLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  222  NMSPAQLREAVSIIDGRAISEASGGITPETVAAVAASGVDLISVGWTTHSAPNLDIGL  279
            NMS  Q+ +A+++I GR+  E SG I   T++   + ++D +S G  THSA +LD+++
Sbjct  225  NMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

249) Mmc1_1475 in NC_008576


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (618),  Expect = 5e-43, Method: Compositional matrix adjust.
 Identities = 109/269 (41%), Positives = 182/269 (68%), Gaps = 2/269 (0%)

Query  6    SDIVRSALAEDIGRGDITTNTLIPAGKEAEAVLIAREELVVCGLPVVSEVFKQVDSRIGI  65
             D +++AL ED+   D +TN+++    +A   L+A+E  V+ GL V   VF   D+ + +
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  66   L--PEASDGAGVMAGNTIFTLRGPARGILTGERVALNFFQNLSAVASLTSQFVEKVAGTG  123
                +  DG  + +G+ ++ + G+ R++LT ERVALNF+Q+LS++AS+T+ +VE +++  
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  124  CRIVDTRKTVPGMRLLQKYAVRVGGGHNHRMGLDDGVLIKENHIAMAGSIREAVAAMHSS  183
             ++ DTRKT P +RL++KYAVRVGGG NHR  L D++++K+NHIA  GS++ A+A  ++ 
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  184  LTHLHRIEVECETLDQVVEALEAGAHILLLDNMTLEQMREAVKINAGRTMLEASGNVTLE  243
               +  +EVE E+L    EA  AG +I++LDNM+LEQ+ +A+ + AGR+ +E SGN+ + 
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  244  TVRDIAETGVDMISSGALTHSAGNKDVSL  272
            T+  +   ++D +SSG+LTHSA + D S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

250) PCC8801_4217 in NC_011726


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (618),  Expect = 6e-43, Method: Compositional matrix adjust.
 Identities = 120/278 (44%), Positives = 181/278 (66%), Gaps = 6/278 (2%)

Query  4    PPIVLDPWLKLWLREDIGRGDRTTQG-LSLHNTGEATWIAKESGIIAGLPIAGRVFQLLS  62
             P+ +D  LK  LRED+   D +T++ +  H  +  + +AKE+G++AGL +  RVF L+ 
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  63   DRSEF--TPLVQEGDRVQSGQVIINIKAPLDVLLMGERVALNLAMRLSGIATLTRQYTEM  120
                F      ++GDR+ SG+++++I +++  LL  ERVALN+  +LSGIA++T  Y E 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  121  IADLPTQLVDTRKTTPGLRILEKYATQMGGAINHRLGLDDAVMIKDNHIQADGSIQTAIT  180
            ++D   ++ DTRKTTP LR++EKYA ++GG+ NHR+ L DA+M+KDNHI A GS+Q AI+
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  181  QIRQRMPYPltievettnlleveeALNYGADIIMLDNMELGLIKQAVAIIRNSNPRVKIE  240
            Q R   P+   +EVE  +L   EEA   G DIIMLDNM L  I QA+++I     R +IE
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIE  245

Query  241  ASGNITLATIRAVAETGVDYISSSAPITRSPWLDLSMR  278
             SGNI ++TI      ++DY+SS++    +  LD+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

251) Cyan8802_4256 in NC_013161


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (618),  Expect = 6e-43, Method: Compositional matrix adjust.
 Identities = 120/278 (44%), Positives = 181/278 (66%), Gaps = 6/278 (2%)

Query  4    PPIVLDPWLKLWLREDIGRGDRTTQG-LSLHNTGEATWIAKESGIIAGLPIAGRVFQLLS  62
             P+ +D  LK  LRED+   D +T++ +  H  +  + +AKE+G++AGL +  RVF L+ 
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  63   DRSEF--TPLVQEGDRVQSGQVIINIKAPLDVLLMGERVALNLAMRLSGIATLTRQYTEM  120
                F      ++GDR+ SG+++++I +++  LL  ERVALN+  +LSGIA++T  Y E 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  121  IADLPTQLVDTRKTTPGLRILEKYATQMGGAINHRLGLDDAVMIKDNHIQADGSIQTAIT  180
            ++D   ++ DTRKTTP LR++EKYA ++GG+ NHR+ L DA+M+KDNHI A GS+Q AI+
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  181  QIRQRMPYPltievettnlleveeALNYGADIIMLDNMELGLIKQAVAIIRNSNPRVKIE  240
            Q R   P+   +EVE  +L   EEA   G DIIMLDNM L  I QA+++I     R +IE
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIE  245

Query  241  ASGNITLATIRAVAETGVDYISSSAPITRSPWLDLSMR  278
             SGNI ++TI      ++DY+SS++    +  LD+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

252) MY9_2769 in NC_017743


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (616),  Expect = 9e-43, Method: Compositional matrix adjust.
 Identities = 115/260 (45%), Positives = 181/260 (70%), Gaps = 3/260 (1%)

Query  16   EDIGSGDLTSQSIFGEQS-CEAEIVAKSEGIFAGAAVIKEGFALLDKNV--QIILHKKDG  72
            ED+ S D ++++IF++++     + AK  G++AG +V++  F+L+D +V  Q   + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  73   DILRKGEVIAVLRGPAAALLSGERVVLNLIQRLSGIATMTREAVHRLDDEQIKICDTRKT  132
            D L  G+++  + G+  +LL+ ERV LN++Q+LSGIA+MT   V+ L+D++IK+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  133  TPGLRMLEKYAVRAGGGYNHRFGLYDGVMIKDNHIAACGSILEACQKARQAVGHMVNIEV  192
            TP LR++EKYAVR GGGYNHRF L D++M+KDNHIAA GS+  A  +AR     +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  193  EIETEDQLREAIEAGADVIMFDNCPPDTVRHFSKLTPDHIKTEASGGITLESLPAFKGTG  252
            E+E+     EA  AG D+IM+DN + + + +   L +++ + E SG I + +++ F+G +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  253  VNYISLGFLTHSVKSLDISM  272
            ++Y+S G LTHS KSLD+SM
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

253) Rcas_1005 in NC_009767


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (616),  Expect = 9e-43, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 186/278 (67%), Gaps = 4/278 (1%)

Query  3    LNSSLHP-DILDAIRRALTEDVGPGDVTTNSIVPPDAAMRGRIIAKQDGVVAGLDVAQAV  61
            +++ L P +I D+++ AL EDV + D +TN+I   ++  +  ++AK+ GV+AGL V Q V
Sbjct  4    ISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRV  63

Query  62   YRAVDERIVFTA--LVAEGERVTNRQPLALVSGPARGLLTAERAALNFLGRMSGIATLTR  119
            +   D  + F       +G+R+T+ + +  + G+ R+LLT ER ALNFL ++SGIA++T 
Sbjct  64   FTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTA  123

Query  120  RFVDAVAGTGATILDTRKTAPGLRMVDKLAVRRGGGRNHRIGLYDMVLIKDNHIDFAGSL  179
             +V+A+++    ++DTRKT+P LR+ +K AVR GGG NHR+ L D +++KDNHI   GS+
Sbjct  124  AYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSV  183

Query  180  RAAVERARAHAPHLE-IEVEARTLDDVREALDLGVQRIMLDNMPPAMMAEAVRLVAGRAR  238
            + A+ +ARA AP +  +EVE  +L    EA   GV+ IMLDNM+   + +A+ L+AGR+R
Sbjct  184  QKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  239  LEASGNVSLDNVRQIAETGVDDISIGALTHSARVFDVS  276
            +E SGN+ +  + ++   ++D +S G+LTHSA+ +D S
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

254) Cha6605_0687 in NC_019697


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  167 bits (616),  Expect = 9e-43, Method: Compositional matrix adjust.
 Identities = 116/288 (41%), Positives = 184/288 (64%), Gaps = 6/288 (2%)

Query  1    MAPTLPPWIVLDAHLRQWLQEDIGRGDRSTQGLPNVDRVSTATWIAKETGLIAALPIAKR  60
            ++  L P  + D  L+  L+ED+   D ST+++ + +  +  + +AKE+G++A+L + +R
Sbjct  4    ISTDLTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  61   VFELLNPQAKFE--PLIAEGAACKLGQPIAEVTANLATLLMGERTALNLTMRLSGIATAT  118
            VF L++++  F+    + +G     G+ + E+ +++ +LL  ER ALN+  +LSGIA+ T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  119  HKYVECIADLPTQLVDTRKTTPGLRLLEKYATTVGGGVNHRVGLDDAVMIKDNHIAAAGG  178
              YVE ++D   ++ DTRKTTP LRL+EKYA  VGGG NHR  L DA+M+KDNHIAA G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  179  INVAIDSIRRAMPYPLTIEVETESLEQVTEAIESQADIIMLDNMSPELMRQAVAMIRSAN  238
            ++ AI   R   P+   +EVE ESL    EA  +  DIIMLDNMS E + QA+++I    
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---A  239

Query  239  PRIKIEASGNITLTTIRQVAETGVDYISTSAPITRSHWLDLSMRIVKF  286
             R +IE SGNI +TTI +    ++DY+S+++    +  LD+SM+ + +
Sbjct  240  GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTY  287

255) PB2503_02572 in NC_014414


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (614),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 113/255 (45%), Positives = 170/255 (67%), Gaps = 3/255 (1%)

Query  29   DLTTGATIAPSQIGTARLSAREKGIACGTEIAAHVFQLLDPEVTIL--RQVSDGTPVSAG  86
            D +T A +     +   L A+E G+  G  +  +VF L+D+EVT+   +Q  DG  +++G
Sbjct  29   DYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSG  88

Query  87   DTVLELCGKATSLLSAERTALNFLGHMMGIASLTAAYVEAVAHTPARIASTRKTLPGLRA  146
            D VLE+ G   SLL+ ER ALNFL H+ GIAS+TAAYVEA+++   ++  TRKT P LR 
Sbjct  89   DLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRL  148

Query  147  IQKYAVQCGGGLAHRYGLHDAVMIKDNHIIAAGGIGHALKAIRARVSHTVKIEIEVDTLA  206
            ++KYAV+ GGG  HR+ L DA+M+KDNHI A G++  A+   RA  +    +E+EV++LA
Sbjct  149  FEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLA  208

Query  207  QLEEVLAAGDADIVLLDNMSQASLREAVALVKGQLLLEASGNVSLETVGAIAETGVDVIS  266
              EE  AAG  DI++LDNMS   + +A++L+ G+  +E SGN+ + T++ +   ++D +S
Sbjct  209  AAEEAAAAG-VDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVS  267

Query  267  SGRLTHSAPNLDIGM  281
            SG LTHSA +LD++M
Sbjct  268  SGSLTHSAKSLDFSM  282

256) nadC in NC_008209


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (614),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 112/265 (43%), Positives = 182/265 (69%), Gaps = 2/265 (0%)

Query  9    LDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPECTFETSR--K  66
            L EDV+  D +++ + D+++ AK ++ A+E+  L+GL + + VF   D+E TF+ ++  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  67   DGERVETGETFAVITGNAQALLTAERVALNLVQRMCGIAGLTAQYVKEIEGTGAILLDSR  126
            DG+R+ +G+    I G+ ++LLT ERVALN++Q++ GIA++TA YV  + +    ++D+R
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  127  KTTPGLRMIEKYAVVCGGGRSHRLGLDSGIMLKDNHIAVAGSIaaavqrakakaPMLTKI  186
            KTTP LR++EKYAV  GGG +HR+ L  +IMLKDNHIA  GS+  A+ +A+A AP +  +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  187  EVEADRLDQVREALDAGVDVIMLDNMSNDDMRKAVKIVDKRIPLECSGGVRLDTIRAKAE  246
            EVE + L    EA  AGVD+IMLDNMS +++ +A+ ++  R  +ECSG + + TI     
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  247  TGVDFVSVGRITQSATCVDIGLDDL  271
             ++D+VS G +T+SA  +D+++ +L
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSMKGL  285

257) DHBDCA_p291 in NC_018866


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (614),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 115/274 (42%), Positives = 179/274 (66%), Gaps = 3/274 (1%)

Query  3    ATFQYEELIERALKEDIGTGDLSTLIIPEDY-QSEARIYAKAHGIICGLFIAEMTFKKID  61
            + FQ ++ +  AL+ED+ + D ST  I ++  Q+   ++AK  G++ GL + +  F  +D
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  62   PYIDVQM--QVEDGDSIGPGTLIMKINGSLAGILQAERTVLNFIQHLSGISSITRRFVEL  119
            + +  Q   Q  DGD + +G L++ I GS+ ++L  ER  LNF+QHLSGI+S+T  +VE 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  120  VSDLGVKVTDTRKTMPGMRNLQKYAVRVGGGTNHRFGLYDAVMLKDNHLDAIGNLAEAVQ  179
            ++D  +KV DTRKT P +R ++KYAVRVGGG NHRF L DA+MLKDNH+ A+G++  A+ 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  180  KIKTKVGHMVKIEVECETLEQVREAVLSGVDVIMLDNMSLQDMKIAVQYINHRVVVEASG  239
            + ++    +  +EVE E+L    EA  +GVD+IMLDNMSL+++  A+  I  R  +E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  240  GVREDTVRQIAETGVDIISVGRLTHSVEAIDFSM  273
             +   T+ ++   ++D +S G LTHS  ++DFSM
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

258) DCF50_p351 in NC_018867


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (614),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 115/274 (42%), Positives = 179/274 (66%), Gaps = 3/274 (1%)

Query  3    ATFQYEELIERALKEDIGTGDLSTLIIPEDY-QSEARIYAKAHGIICGLFIAEMTFKKID  61
            + FQ ++ +  AL+ED+ + D ST  I ++  Q+   ++AK  G++ GL + +  F  +D
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  62   PYIDVQM--QVEDGDSIGPGTLIMKINGSLAGILQAERTVLNFIQHLSGISSITRRFVEL  119
            + +  Q   Q  DGD + +G L++ I GS+ ++L  ER  LNF+QHLSGI+S+T  +VE 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  120  VSDLGVKVTDTRKTMPGMRNLQKYAVRVGGGTNHRFGLYDAVMLKDNHLDAIGNLAEAVQ  179
            ++D  +KV DTRKT P +R ++KYAVRVGGG NHRF L DA+MLKDNH+ A+G++  A+ 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  180  KIKTKVGHMVKIEVECETLEQVREAVLSGVDVIMLDNMSLQDMKIAVQYINHRVVVEASG  239
            + ++    +  +EVE E+L    EA  +GVD+IMLDNMSL+++  A+  I  R  +E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  240  GVREDTVRQIAETGVDIISVGRLTHSVEAIDFSM  273
             +   T+ ++   ++D +S G LTHS  ++DFSM
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

259) Terro_1520 in NC_018014


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (615),  Expect = 1e-42, Method: Compositional matrix adjust.
 Identities = 118/286 (42%), Positives = 176/286 (62%), Gaps = 15/286 (5%)

Query  2    SLSPELIERVVRMALDEDAPWGDITSETLIPADALVTAQLVAREDGVLCGAEIFAAAMVM  61
             L+P  I+  ++ AL ED    D ++++++  ++     L A+E GVL G  +F     +
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   CDSGIVVEFAVEDASQFSAGQTLAS------ITGPARGVLRGERVALNFTQRLSGIATMT  115
             D+ +    + +++ QF  G+ L+S      I G+ R++L  ERVALNF Q+LSGIA+MT
Sbjct  67   FDAEV----TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  116  ARYVAQTTGTKARIVDTRKTTPGLRQFERYAVRCGGGWNHRFSLSDAVMAKDNHLAIVAE  175
            A YV    + + ++ DTRKTTP LR FE+YAVR GGG NHRF+LSDA+M KDNH+A V+ 
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG-  181

Query  176  SGSLSLTEALLAARKRLPHTTHVEVEVDRPDQIEPVLAGGVDTIMLDNFSTDAMRDAVAQ  235
                S+  A+  AR   P    VEVEV+     E   A+GVD IMLDN S + + +A++ 
Sbjct  182  ----SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL  237

Query  236  IAGRALIEASGGITLGRIREIAETGVDVISVGALTHSVRALDLGLD  281
            IAGR+ IE SG I +  I  +   ++D +S G+LTHS ++LD+++ 
Sbjct  238  IAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

260) Syn6312_3664 in NC_019680


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (613),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 114/276 (42%), Positives = 187/276 (68%), Gaps = 9/276 (3%)

Query  10   LDTLLQAWLQEDIGRGDRTTQALGLGEQTGQAELEI--KQAGMIAGLSIFGRVFQLLQPT  67
            +D  L+A L+ED+   D +T+A+   ++ GQA + +  K+AG++AGL++F RVF L+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIF--DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  68   AQIE--LLIQDGEPANPSQIAARVTASLETLLLGERVALNLVMHLSGVASLTRIYADLIA  125
              ++    ++DG+   ++++   + +S+ +LL  ERVALN++ HLSG+AS+T  Y + ++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  126  DLPTQLVDTRKTTPGLRLLEKYATQVGGAINHRLGLDDAVMIKDNHIQAAGGIAQALDQI  185
            D   ++ DTRKTTP LRL+EKYA +VGG+ NHR+ L DA+M+KDNHI A G++ +A+ Q 
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  186  RTQIPFTHKIEVETETLGQVQTALAAGADIIMLDNMPIERMTQAVDMIRHQRPEVKIEAS  245
            R+  PF   +EVE E+L+  + A AAG DIIMLDNM++E++ QA+ +I  +    +IE S
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECS  247

Query  246  GNITQETIRTVALTGVDYISTSATITRSPWLDCSLN  281
            GNI   TI      ++DY+S+++    +  LD S++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

261) Rvan_0617 in NC_014664


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  166 bits (613),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 111/271 (41%), Positives = 182/271 (68%), Gaps = 6/271 (2%)

Query  20   IRDALAEDLGLAGDITTNAIIAPDDVTEAVLALREDGCIAGLPLAEAAFRALDPGISFAA  79
            ++ AL ED+  + D +TNAI+  ++ +   L  +E G +AGL + +  F  +D+ ++F  
Sbjct  17   LKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  80   --ELRDGETAHAGSVIARVSGSTRAILSAERVALNLVQHLSGVATATRHFVEAVHGTHAR  137
              +++DG+   +G ++  + GS R++L+ ERVALN++QHLSG+A+ T  +VEA+ + + +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  138  IVCTRKTTPGLRAFEKYAVRAGGGYNHRFGLFDAVLIKDNHIAAAGDVSAAIDLARAANG  197
            +  TRKTTP LR FEKYAVR GGGYNHRF L DA+++KDNHIAA G V  AI  ARA   
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  198  HMVKIEVEVDTLTQLEEALRHDVDAVLLDNMAVPELKSAVARAKTAKPGILCEASGGVRL  257
             +  +EVEV++L+  EEA   +VD ++LDNM++ ++  A++   ++++ I C  SG + +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI-AGRSRIEC--SGNIDM  252

Query  258  VTVRAIAETGVDMISVGALTHSVKALDIGLD  288
             T+  +   ++D +S G+LTHS K+LD+++ 
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

262) nadC in NC_014551


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 119/272 (44%), Positives = 187/272 (69%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTRFFQEDIGTGDVTSQAIFSDE-HCKAKIIAKTDGVFAGETVIREGFGLLHND  62
            +Q+ + L   ++ED+ + D +++AIF ++ + K  ++AK  GV+AG TV++  F L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKEDVLAEMEGPAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+   D++ E+ G+  +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRIGGGCNHRFGLYDGIMIKDNHIAACGSIKAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVR+GGG NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKAAGQMLAAEVEIETEQQLLEAIDAGADIIMFDNCPPETVRRFAGMTPGHIKTEASGGI  240
            R  A  +   EVE+E+     EA  AG DIIM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPGYRGTGVHYISLGFLTHSVKSADISM  272
             + T++ +RG +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

263) Calow_1005 in NC_014657


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 117/270 (44%), Positives = 185/270 (69%), Gaps = 2/270 (0%)

Query  7    IDKIIKDALVEDMPYGDITTDLLIPQESTSIAVLLAKENGILCGIDVAKRVFEILDGNIK  66
            ID  +K AL ED+   D +T+ ++ +++ +   L+AKE G+L G+ V +RVF ++D+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLKA--DGEFINKGDVLAKIDGSTRAILKGERLALNLLQRMSGIATFTNMLAQKIKGY  124
            F++     DG+ +  GD++  I GS R++L  ER+ALN+LQ++SGIA+ T    + + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  KATVTDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKAVGSITEAVKRAKE  184
            +  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI AVGS+  A+ +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NIPHTMKVEVEVRNMQEFEEALSAGADIIMLDHFTVDEMRKAIEKAEGRVLIEASGNVNV  244
              P    VEVEV ++   EEA +AG DIIMLD+ +++++ +AI    GR  IE SGN+++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DNIEEIAKTGVDIISVGSITHSVKSLDISL  274
              I  +   ++D +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

264) Ple7327_1506 in NC_019689


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 122/279 (44%), Positives = 186/279 (67%), Gaps = 6/279 (2%)

Query  10   PPIVLEGLLQSWLLEDIGRGDRATQGIFPQTATAGKAEWIAKEAGIIAGLPVAARVFQLL  69
             P+ +++ L++ L ED+   D +T++IF + + A K   +AKEAG++AGL V  RVF L+
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQA-KVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  70   DRQVNF--VPLVAEGQAVKPAEVIARIEGATDALLMGERVALNLAMRLSGIATLTRQYAD  127
            D +V F       +G+ + +++++  I G+  +LL  ERVALN+  +LSGIA++T  Y +
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  128  AIADLPTQLVDTRKTTPGLRILEKYATQVGGAANHRMGLDDAVMIKDNHiaaaggireai  187
            A++D   ++ DTRKTTP LR++EKYA +VGG+ NHR  L DA+M+KDNHIAA G+++ AI
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  188  aaVRKTMPYPLTIEVETTSIAEVEAALAGGVDIIMLDNMTIEEMKQAVQSIRARNDKVKI  247
            A  R   P+   +EVE  S+A  E A A+GVDIIMLDNM++E++ QA+  I +R+   +I
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RI  244

Query  248  EASGNITLNNIRGVAETRVDYISSSAPITRSTWLDLSMK  286
            E SGNI +  I       +DY+SS++    +  LD+SMK
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

265) nadC in NC_018645


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 116/271 (43%), Positives = 181/271 (67%), Gaps = 4/271 (1%)

Query  5    ENIIKLALFEDSGLGDITTESILSESFLGKGVIVAKESFVLAGIEVAKKTFKLLDKDCEV  64
            ++ +K AL ED    D +T++I+ +   +K  + AKE+ VLAG+ V ++ F L+D +   
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV-T  72

Query  65   FSS---FSDGSNIKQGDIVFKAQGDLVALLKGERVALNFLQRLSGIATLTRSYADELKFP  121
            F +   F DG  +  GD+V+   G + +LL  ERVALNFLQ+LSGIA++T +Y + L   
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  122  NVRLTDTRKTTPGLRGLEKEAVRAGGAYNHRMSLYDGVLIKDNHIAVAGSIKSAVYAVRN  181
             +++ DTRKTTP LR +EK AVR GG+YNHR +L D++++KDNHIA  GS++ A+   R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  182  RISHLMKIEVEVTNLDEVKEAVDEGVDVIMLDNMDYDQMSAAVNYINGRAVVEASGNVSL  241
              + +  +EVEV +L    EA   GVD+IMLDNM  +Q+  A+  I GR+ +E SGN+ +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  242  GTLNKIAATGVDVISCGALTHQARSVDLSMR  272
             T++++ + ++D +S G+LTH A+S+D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

266) Dole_1728 in NC_009943


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 117/278 (43%), Positives = 192/278 (70%), Gaps = 10/278 (3%)

Query  4    LIPYIIE----SGLSEDIGAGDITTDALIDAEAMGRGYIVAKEDLVIAGLNAAAAVFETL  59
            L P+ I+    ++L ED+ + D +T+A++D ++ ++  + AKE  V+AGL     VF  +
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   DPEMACLFMAT----DGDRVKTGTKVMQMEGSMQALLKGERLALNILQRLSGIATFTRAC  115
            D+E++  F       DGDR+ +G  V+++ GS+++LL  ER+ALN+LQ+LSGIA+ T A 
Sbjct  68   DAEVT--FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  116  VDELAGTTVRLVDTRKTTPGLRVLEKYAVRAGGAANHRMGLFDGVLIKDNHIAACGGIaq  175
            V+ L++  +++ DTRKTTP LR++EKYAVR GG+ NHR  L D++++KDNHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  176  avakaraaVHHLVKIEIEVSNQDEVAQALEAGADVIMLDNMDMEAIRQAVNTISGRALVE  235
            A+A+ARA    +  +E+EV +     +A  AG D+IMLDNM +E I QA+  I+GR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  236  VSGSVARENLRALADTGVNIISMGSLTHSARAVDLSMR  273
             SG++    +  + + +++ +S GSLTHSA+++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

267) mll5833 in NC_002678


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 117/281 (42%), Positives = 196/281 (70%), Gaps = 6/281 (2%)

Query  2    TSLAPLPQIIMEPIVRSALLEDLGRAGDITSDAIIPADCKATLALNARQAGVVAGLDLVM  61
            T L+P+    ++  +++AL ED+ ++ D +++AI+  + +A ++L A++AGV+AGL +  
Sbjct  6    TDLTPFQ---IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  62   FAFLLVDPGISIQ--LRCPEGGKVSAGQTIAIVNGPARSLLTAERTALNFLCKLSGIATA  119
              F L D+ +++Q   +  +G+++++G+ +  + G+ RSLLT ER ALNFL  LSGIA+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  120  TATLVNAVRGHNAKIVCTRKTTPGLRVLEKYAVRAGGGANHRFALDDAVLIKDNHIAIAG  179
            TA+ V+A+ ++  K+  TRKTTP LR++EKYAVR GGG NHRF L DA+++KDNHIA  G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  180  DirtaierarraiGHMVKIEVEVDRLDQLEIALTAGVDAVLLDNMSVEDLAQAVAMVGGR  239
             ++ AI +AR     +  +EVEV+ L   E A +AGVD ++LDNMS+E++ QA+++++GR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  240  AITEASGRVTRASAPAIAATGVDLISVGWLTHSAPILDIGL  280
            +  E SG +  ++ + + + ++D +S G LTHSA  LD+++
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

268) nadC in NC_015730


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 111/265 (42%), Positives = 184/265 (70%), Gaps = 2/265 (0%)

Query  16   LDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPDCTFETSR--K  73
            L EDV+  D +++ + D+++ AK ++ A+E+  L+GL + + VF   D++ TF+ ++  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  74   DGERVETGETFAVITGNAQALLTAERVALNLVQRMCGIAGLTAEYVKEIEGTGAILLDSR  133
            DG+R+ +G+    I G+ ++LLT ERVALN++Q++ GIA++TA YV  + +    ++D+R
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  134  KTTPGLRMIEKYAVVCGGGRSHRLGLDNGIMLKDNHIAVAGSIaaavqrakakaPMLTKI  193
            KTTP LR++EKYAV  GGG +HR+ L ++IMLKDNHIA  GS+  A+ +A+A AP +  +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  194  EVEADRLDQVHEALDAGVDVIMLDNMSNEDMRKAVEIVDKRIPLECSGGVRLDTIRAKAE  253
            EVE + L   +EA  AGVD+IMLDNMS E++ +A+ ++  R  +ECSG + + TI     
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  254  TGVDFVSVGRITQSATCVDIGLDDV  278
             ++D+VS G +T+SA  +D+++ ++
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSMKGL  285

269) Tthe_0548 in NC_014410


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (611),  Expect = 2e-42, Method: Compositional matrix adjust.
 Identities = 109/261 (42%), Positives = 176/261 (68%), Gaps = 2/261 (0%)

Query  15   LMEDLTWGDITTDILVPKGTKSKGYVYAKDDGIIAGIDVFLMVFNTIDSDIEYKK--YFK  72
            L ED+   D +T+ +     ++K  ++AK+ G++AG+ VF  VF  +D+++ +++   FK
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  73   DGEAVKKGDLILETYGDLNSCLKAERVALNLIQRMSGIATYVRKLSDMIKGTNARLTDTR  132
            DG+ +  GDL+LE  G + S L  ERVALN++Q++SGIA+      + + +   ++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  133  KTMPGLRYFDKYAVSVGGGVNHRYNLSDGILIKDNHIKAVGGIKNALTMIKSGISHTKKV  192
            KT P LR F+KYAV VGGG NHR+NLSD+I++KDNHI AVG++++A++  ++  +  K V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  193  EIEVETIHELKEALKYGADIIMLDNMTIDMMKEAVEITNGRAILEASGNINEINILDVAK  252
            E+EVE++    EA   G DIIMLDNM+++ + +A+ +  GR+ +E SGNI+   I     
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  253  TGVDIISIGAITHSVKALDIS  273
             ++D +S G++THS K+LD+S
Sbjct  261  LAIDYVSSGSLTHSAKSLDFS  281

270) TtJL18_1062 in NC_017587


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (609),  Expect = 3e-42, Method: Compositional matrix adjust.
 Identities = 130/272 (48%), Positives = 198/272 (73%), Gaps = 4/272 (1%)

Query  6    HLDEALRAWLLEDLGPGDLTSSLLVPEALEGEAVVLAKEAGVVAGLPVAGRVFALADPKV  65
            ++D++L+A L ED+ + D +++ +  +  ++   ++AKEAGV+AGL V  RVF+L D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  66   AF--TPLVAEGAWVERGQEVARVAGPLRGILAGERLALNLLQRLSGIATLTRAYVEALKG  123
            +F       +G ++  G+ V  + G++R++L+ ER+ALN+LQ+LSGIA++T AYVEAL +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  124  TKAQVLDTRKTTPGLRALEKYAVRVGGGRNHRFGLFDGILIKENHIRAAGGVKEAVRRAK  183
             + +V+DTRKTTP LR +EKYAVRVGGG NHRF L D+I++K+NHI A G+V+ A+ +A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  184  AGAPHYLK-VevevtglaeleealeagadlilldNFPLEAIRDAVRRVGGRVPLEASGNM  242
            A AP ++K VEVEV +LA  EEA  AG D+I+LDN +LE I +A+  ++GR  +E SGN+
Sbjct  192  AYAP-FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  243  TLERAREAAEAGVDYVSVGALTHSAKALDLSL  274
             +         ++DYVS G+LTHSAK+LD+S+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

271) Cal6303_0642 in NC_019751


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (609),  Expect = 3e-42, Method: Compositional matrix adjust.
 Identities = 117/265 (45%), Positives = 175/265 (67%), Gaps = 6/265 (2%)

Query  24   EDIGRGDRTTQSLLSANSIPKKAEWIAKAPGVIAGLPIAARVFYLLNNQVTF--APLIAE  81
            ED+   D +T++++  ++   K   +AK +GV+AGL +  RVF L++ +VTF  +  + +
Sbjct  23   EDVHSEDYSTNAIFDHHG-QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKD  81

Query  82   GENCQPGQIIAEIEGSLDALLMGERVALNLVMGLSGISSLTQKYVEKITDLPAKLVDTRK  141
            G+   +G+++ EI GS+ +LL  ERVALN++  LSGI+S+T  YVE + D   K+ DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  142  TTPGLRILEKYATQLGGAINHRMGLDDAVMLKDNHITAVggigaaigKVRSHIPYPLTIE  201
            TTP LR++EKYA ++GG+ NHR  L DA+MLKDNHI+AVG++  AI++ R+  P+   +E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  202  VETESLEQVQEALEHQADIIMLDNMSAAMMEVAVKTIRAANNRVKIEASGNVTLETIRTV  261
            VE ESL   +EA     DIIMLDNMS   +E A+  I     R +IE SGN+ + TI   
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRF  258

Query  262  AETGVDYISSSAPITQSKWLDLSMK  286
               ++DY+SS++    +K LD+SMK
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

272) nadC in NC_017190


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (608),  Expect = 3e-42, Method: Compositional matrix adjust.
 Identities = 117/275 (43%), Positives = 187/275 (68%), Gaps = 3/275 (1%)

Query  1    MNILQLKQMLTRFFQEDIGTGDVTSQAIFSDE-HCKAKIIAKTDGVFAGEAVIREGWGLL  59
            +  +Q+ + L   ++ED+ + D +++AIF ++ + K  ++AK  GV+AG +V++    L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   HNDIRIRSLK--KDGERMKKEDVLAEIEGPAAALLTGERVILNLIQRMSGIATMTDEAKR  117
            + ++ +++    KDG+R+   D++ EI G+  +LLT ERV LN++Q++SGIA+MT     
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  118  RLDDPSIKLCDTRKTTPGLRMLEKYAVRIGGGCNHRFGLYDGIMIKDNHIAACGSIKAAM  177
             L+D  IK+ DTRKTTP LR++EKYAVR+GGG NHRF L D+IM+KDNHIAA GS++ A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  178  ERARKAAGQMLAAEVEIETEQQLLEAIDAGADVIMFDNCPPETVRRFAGMTPGHIKTEAS  237
             +AR  A  +   EVE+E+     EA  AG D+IM+DN + E + +   + +G+ + E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  238  GGITLDTLPDYRGTGVHYISLGFLTHSVKSADISM  272
            G I + T++ +RG +++Y+S G LTHS KS D+SM
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

273) nadC in NC_017188


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (608),  Expect = 4e-42, Method: Compositional matrix adjust.
 Identities = 117/272 (44%), Positives = 186/272 (69%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTRFFQEDIGTGDVTSQAIFSDE-HCKAKIIAKTDGVFAGEAVIREGWGLLHND  62
            +Q+ + L   ++ED+ + D +++AIF ++ + K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKEDVLAEIEGPAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+   D++ EI G+  +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRIGGGCNHRFGLYDGIMIKDNHIAACGSIKAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVR+GGG NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKAAGQMLAAEVEIETEQQLLEAIDAGADVIMFDNCPPETVRRFAGMTPGHIKTEASGGI  240
            R  A  +   EVE+E+     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPDYRGTGVHYISLGFLTHSVKSADISM  272
             + T++ +RG +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

274) nadC in NC_017191


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (608),  Expect = 4e-42, Method: Compositional matrix adjust.
 Identities = 117/272 (44%), Positives = 186/272 (69%), Gaps = 3/272 (1%)

Query  4    LQLKQMLTRFFQEDIGTGDVTSQAIFSDE-HCKAKIIAKTDGVFAGEAVIREGWGLLHND  62
            +Q+ + L   ++ED+ + D +++AIF ++ + K  ++AK  GV+AG +V++    L++ +
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  63   IRIRSLK--KDGERMKKEDVLAEIEGPAAALLTGERVILNLIQRMSGIATMTDEAKRRLD  120
            + +++    KDG+R+   D++ EI G+  +LLT ERV LN++Q++SGIA+MT      L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  121  DPSIKLCDTRKTTPGLRMLEKYAVRIGGGCNHRFGLYDGIMIKDNHIAACGSIKAAMERA  180
            D  IK+ DTRKTTP LR++EKYAVR+GGG NHRF L D+IM+KDNHIAA GS++ A+ +A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  181  RKAAGQMLAAEVEIETEQQLLEAIDAGADVIMFDNCPPETVRRFAGMTPGHIKTEASGGI  240
            R  A  +   EVE+E+     EA  AG D+IM+DN + E + +   + +G+ + E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  TLDTLPDYRGTGVHYISLGFLTHSVKSADISM  272
             + T++ +RG +++Y+S G LTHS KS D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

275) Psyr_0815 in NC_007005


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  165 bits (608),  Expect = 4e-42, Method: Compositional matrix adjust.
 Identities = 115/278 (42%), Positives = 196/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDVGSGDITAQLIPAER-LAKATIISRDTAVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL EDV S D +++ I  ++  AK ++++++++V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVTDGDRVNPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQYF  122
             +D+ V+ +   Q  DGDR+ + + ++++ G+ RSLLT ER ALNFLQ LSG+A+ +  +
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADMVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIAQ  182
             + +++ ++K++DTRKT P LR+ +KYAV  GG  NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AVEAAHRIAP-GKPVEVEVESLGELKQALDAGADIIMLDELSLDDMREAVRLTAGRASLE  241
            A+  A+  AP  K VEVEVESL+   +A  AG DIIMLD++SL+++ +A+ L AGR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG I+  T+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

276) Dtox_2252 in NC_013216


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  164 bits (607),  Expect = 4e-42, Method: Compositional matrix adjust.
 Identities = 112/269 (42%), Positives = 187/269 (70%), Gaps = 2/269 (0%)

Query  7    DKIINDALLEDIGRGDITTKTIIAADMEAQAVFISRNAGIVAGLDIAGRVFEKLDPHYSL  66
            D  ++ AL ED+   D +T++I+  + +A+  +++++AG++AGL +  RVF  +D++ ++
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  67   EKI--ISDGDQVQAGEAIARVSGKAHALLSGERVALNFLQHLSGIATETRNIVEIVKPFG  124
            ++   + DGD++ +G+ +  + G  ++LL+ ERVALNFLQHLSGIA+ T   VE +    
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  125  VRIADTRKTTPGLRMFEKYAVTVGGGYNHRMGLDDAVLIKDNHLQIAGGVKQAVELVRNK  184
            +++ DTRKTTP LR+FEKYAV VGGGYNHR  L DA+++KDNH+   G+V++A+   R  
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  185  IGHLVKIEVEVETWTQLEEAVQAGVDVIMLDNMNTETMQKAVKFVGRRAVTEASGQItaa  244
               +  +EVEVE+ +  EEA  AGVD+IMLDNM+ E +++A+ +++ R+  E SG+I  +
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  245  nagavaatgvDVLSLGWITHSARPLDISL  273
              +   + ++D +S G +THSA++LD+S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

277) nadC in NC_016047


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  164 bits (605),  Expect = 5e-42, Method: Compositional matrix adjust.
 Identities = 114/254 (45%), Positives = 175/254 (69%), Gaps = 3/254 (1%)

Query  3    DLTSQAIFREQS-CEAEIVAKSDGIFAGAAVIKEGFALLDENV--QTILHKTDGDILRKG  59
            D +++AIF +++     + AK  G++AG +V++  F+L+D +V  Q   +  DGD L  G
Sbjct  29   DYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSG  88

Query  60   EVIAVLRGPAAALLSGERVVLNLIQRLSGIATMTREAVRRLDDEQIKICDTRKTTPGLRM  119
            +++  + G+  +LL+ ERV LN++Q+LSGIA+MT   V  L+D++IK+ DTRKTTP LR+
Sbjct  89   DLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRL  148

Query  120  LEKYAVRAGGGYNHRFGLYDGVMIKDNHIAACGSILEACQKARQTVGHMVNIEVEIETEE  179
            +EKYAVR GGGYNHRF L D++M+KDNHIAA GS+  A  +AR     +  +EVE+E+  
Sbjct  149  FEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLA  208

Query  180  QLREAIEAGADVIMFDNCPPETVRHFATLTPDHIKTEASGGITLESLAAFKGTGVNYISL  239
               EA  AG D+IM+DN + E + +  TL +++ + E SG I + +++ F+G +++Y+S 
Sbjct  209  AAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSS  268

Query  240  GFLTHSVKSLDISM  253
            G LTHS KSLD+SM
Sbjct  269  GSLTHSAKSLDFSM  282

278) Dalk_0496 in NC_011768


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  164 bits (606),  Expect = 5e-42, Method: Compositional matrix adjust.
 Identities = 115/266 (44%), Positives = 176/266 (67%), Gaps = 6/266 (2%)

Query  32   ALEEDLATGDITTDPIVPPDRKGEAVIKAKEDLLVAGMDMVRIVFDAVDPKIRIDVLTP-  90
            AL ED+ + D +T++I   + ++   + AKE  ++AG+ + + VF   D+ + ++   P 
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ--NPH  77

Query  91   ---DGARAKPGDIMARLSGRLRPLLWGERTALNFLQRLCGIATHTHAHVQEAKGRDVKLV  147
               DG R  +GD++  + G +R+LL  ER ALNFLQ+L GIA+ T A V+   +  +K+ 
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  148  DTRKTTPGWRLLEKYAVRVGGASNHRMGLFDGVLIKDNHIVAAGGITQAVGLARKGAPHM  207
            DTRKTTP  RL+EKYAVRVGG+ NHR  L D++++KDNHI A G++ +A++ AR  AP +
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  208  VRIEVEAASMNEVQEALDAKADVIMLDNMNPDQISQAVQLIAGKALVEVSGGIKKETIRT  267
              +EVE  S+   +EA  A  D+IMLDNM+ +QI QA+ LIAG++ +E SG I   TI  
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISR  257

Query  268  MARTGVNILSCGALTHGARSVDISMK  293
                +++ +S G+LTH+A+S+D+SMK
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFSMK  283

279) nadC in NC_011989


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  164 bits (607),  Expect = 5e-42, Method: Compositional matrix adjust.
 Identities = 121/284 (43%), Positives = 180/284 (64%), Gaps = 6/284 (2%)

Query  5    SLPRVIVEPLVRNALSEDLGLAGDITSMAVIPADHRSTVQIASRRDGVIAGLDVSAIAFE  64
             L    ++  ++ AL ED+  + D ++ A++  + ++ V + ++  GV+AGL V    F 
Sbjct  7    DLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   LVDPGLVM-TPH-VSDGAAVKAGDVLATISGSSRSLLTGERVALNFLGHLSGIATVTRQI  122
            L D+ +    PH   DG  + +GD++  I GS RSLLT ERVALNFL HLSGIA++T   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  VDAVSGTKAAVACTRKTIPGLRALEKYAVRMGGGMNHRFALYDAVLIKDNHVAIAGSVTQ  182
            V+A+++ +  V  TRKT P LR +EKYAVR+GGG NHRF L DA+++KDNH+A  GSV +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AILRARGGVGHMVKIEVEVDTLDQLREAMEIGVDAVLLDNMTPEQLREAVEIVAGRSITE  242
            AI +AR+    +  +EVEV++L    EA   GVD ++LDNM+ EQ+ +A+ ++AGRS  E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  243  ASGGITPQTARAVAQSGVDLLSVGWITHSAPVLDI---GLDFVE  283
             SG I   T       ++D +S G +THSA  LD+   GL +++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLD  289

280) GEI7407_0212 in NC_019703


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  164 bits (605),  Expect = 7e-42, Method: Compositional matrix adjust.
 Identities = 131/282 (47%), Positives = 187/282 (67%), Gaps = 9/282 (3%)

Query  7    LPPWVVLDAMLEDWLREDIGRGDRTTQSIFGTD-EAKVSGEWRVKEQGVIAGLAVAARVF  65
            L P  + D  L   LRED+   D +T++IF+ + +AKVS     KE GV+AGL+V  RVF
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQAKVS--LFAKEAGVLAGLTVFQRVF  64

Query  66   RLLDSEASFVA--EVPDGTMCDRAQVVARLHGSPVALLMGERVALNLAMRLSGIATATRR  123
             L+D+E +F    +  DG     +++V  + GS  +LL  ERVALN+  +LSGIA+ T  
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  124  YVDQIADLPTQLVDTRKTTPGLRLLEKYATQVGGAMNHRMGLDDGVMIKDNHiaaaggig  183
            YV+ ++D   ++ DTRKTTP LRL+EKYA +VGG+ NHR  L D++M+KDNHIAA G++ 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  184  paiaRVRGRVPYPLTIEVETETLAQVEEALAAGADIIMLDNMAIAQMQEAVQRIRQVSGR  243
             AIA+ R+  P+   +EVE E+LA  EEA AAG DIIMLDNM++ Q+++A   I  ++GR
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQA---ITLIAGR  241

Query  244  IKIEASGNITLETIRAVAETGVDYVSTSAPITRSTWLDLSMK  285
             +IE SGNI + TI      ++DYVS+++    +  LD+SMK
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

281) nadC in NC_014640


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  164 bits (605),  Expect = 7e-42, Method: Compositional matrix adjust.
 Identities = 114/268 (43%), Positives = 179/268 (67%), Gaps = 3/268 (1%)

Query  29   RAALLEDLGRAGDLTTDAIVPADATAQTRLVARQEGVLAGLDLARLAFRAMDPDIKFEVA  88
            +AAL ED+ ++ D +T+AI   ++ A+  L A++ GVLAGL + +  F   D+++ F+ +
Sbjct  18   KAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  89   --LRDGSELQPGAEIARISGNARAMLTAERVALNFLCHLSGVASATASIARAIEGYGARV  146
              ++DG  L +G  +  I G+ R++LT ERVALNFL HLSG+AS TA+   A+ +   +V
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  147  TCTRKTMPGLRAVQKYAVRVGGGSNHRHGLDDAVLIKDNHIALAGGVATAVERARAGIGH  206
              TRKT P LR  +KYAVRVGGG NHR  L DA+++KDNHIA  G+V  A+ +ARA    
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  207  MVKIELEVDTLEQLETALSLGVDVVLLDNMSLDDLRRAVAMARGRAITEASGRITPETAA  266
            +  +E+EV++L   E A + GVD+++LDNMSL+++ +A+++  GR+  E SG I   T +
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  267  AVAATGVDQIAVGWITHSAKVLDIGLDA  294
               + ++D ++ G +THSAK LD+++ +
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

282) Dgeo_1163 in NC_008025


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (601),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 114/264 (44%), Positives = 187/264 (71%), Gaps = 7/264 (2%)

Query  14   EDIGRGDATTLATIPPEQTARAEFLLKEPGILSGLAVVRRVFALLDPD--LQVTWTAREG  71
            ED+   D +T A +  +  A+  ++ KE+G+L+GL+V +RVF+L+D++  +Q     ++G
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  72   EWRERG-VIGSVTGPARPLLSGERVALNLLQRLSGIATLTRRYVDALKGGHARLLDTRKT  130
            ++   G ++  + G+ R+LL+ ERVALN+LQ+LSGIA++T  YV+AL +++ +++DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  131  TPLWRDLEKEAVRQGGGTNHRAGLDDGILIKDNHVAAAGSIGAAIERARN-ASYLLKVEC  189
            TP  R +EK AVR GGG NHR  L D+I++KDNH+AA GS+  AI +AR  A+++  VE 
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  190  EVPDLTGLEEALRAGVDRVLLDNMSDDLLAEAVRVRDRLAPHVTLEASGNMTLERLPRVA  249
            EV  L++ EEA  AGVD ++LDNMS + + +A+ +   +A +  +E SGN+ +  ++R  
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL---IAGRSRIECSGNIDMTTISRFR  259

Query  250  ASGVDFVSVGALTHSAPALDISLN  273
            + ++D+VS G+LTHSA +LD+S++
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

283) Rleg2_6035 in NC_011366


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (603),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 113/260 (44%), Positives = 179/260 (69%), Gaps = 5/260 (1%)

Query  29   ITSASVIPHDHRSTVVMAARQPGVIAGLDAAELAFALVDPEITMR--RHLQDGDAVKPGD  86
             ++ +++ H+ ++ V + A+++GV+AGL   +  F+L D+E+T +  ++++DGD + +GD
Sbjct  30   YSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGD  89

Query  87   VIATIEGPSRGLLTAERTALNFLGHLSGiatvtaeiaaairatkasvaCTRKTTPGLRAL  146
            ++  I G+ R+LLT ER ALNFL HLSGIA++TA    A+   +  V  TRKTTP LR +
Sbjct  90   LVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLF  149

Query  147  EKYAVRAGGGMNHRFALYDAVLIKDNHVAIAGGVAEAIRRARAGVGHLVKIEVEVDTLDQ  206
            EKYAVR GGG NHRF L DA+++KDNH+A  G+V  AI +ARA    +  +EVEV++L  
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAA  209

Query  207  LREAMETGVDAVLLDNMTPDQLRQAVAIVAGRAITEASGRVTPATAGAIAASGVDLISIG  266
              EA  +GVD ++LDNM+ +Q+ QA++++AGR+  E SG +  +T + + + ++D +S G
Sbjct  210  AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  267  WLTHSAPVLDI---GLDFIE  283
             LTHSA  LD+   GL +++
Sbjct  270  SLTHSAKSLDFSMKGLTYLD  289

284) nadC in NC_009925


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (602),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 123/288 (43%), Positives = 185/288 (65%), Gaps = 14/288 (4%)

Query  2    ATLPPWLILDPLLQTWLAEDIGRGDRTTQALWPEGSEAHWGQAELRL--KQSGVVAGLPL  59
            + L P  I D  L++ L ED+   D +T+A+       H GQA + L  K++GV+AGL +
Sbjct  6    TDLTPFQI-DDTLKAALREDVHSEDYSTNAIF-----DHHGQAKVSLFAKEAGVLAGLTV  59

Query  60   FQRVFHLLSSQVAIN--PLVPEGKNSPSGTVVAQLQGPMGALLMGERVALNLIMPLSGIA  117
            FQRVF L+ ++V+++      +G    SG +V ++ G++ +LL  ERVALN++  LSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  118  SLTRTYAEKIADLPTQLVDTRKTTPGLRILEKYATQVGGAVNHRMGLDDAVMIKDNHIFA  177
            S+T +Y E ++D   ++ DTRKTTP LR++EKYA +VGG+ NHR  L DA+M+KDNHI A
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  178  AGGIGEAIRRVRQHIPFPLAIevetetleqvqqAVDHQADIIMLDNMAVEQMQSAVKLIR  237
             G++  AI + R   PF   +EVE E+L   ++A     DIIMLDNM++EQ++ A+ LI 
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI-  238

Query  238  SQCANTVKIEASGNINLQTIRAVAETGVDYISTSATITQASWLDLSLK  285
               A   +IE SGNI++ TI      ++DY+S+++    A  LD+S+K
Sbjct  239  ---AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

285) Bind_3492 in NC_010581


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (602),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 120/280 (43%), Positives = 193/280 (69%), Gaps = 3/280 (1%)

Query  8    ISPQLPRLLVEPLVRAALLEDLGRAGDITSDAIVPAHQQARMALNARQPGIVSGLSAAKL  67
            IS +L  + ++  ++AAL ED+ ++ D +++AI   H QA+++L A+++G+++GL+  + 
Sbjct  4    ISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  68   AFELIDPAIAVTVHHP--DGTRIKPGDVIAHIAGPARSILTAERVALNFLGHLSGvasat  125
             F L+D+ ++    H   DG R+ +GD++ +I G+ RS+LT ERVALNFL HLSG+AS T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  126  atlvaavaytraQIVCTRKTTPGLRSLEKLAVRHGGGGNHRFGLDDAMLIKDNHVALAGG  185
            A+ V A++  R ++  TRKTTP LR +EK AVR GGG NHRF L DA+++KDNH+A  G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  186  ITEALRRAKQGAGHLVKIELEVDTLAQLEEALAEGVDAVLLDNMTPELLSQAVVMVAGRA  245
            +  A+ +A+  A  +  +E+EV++LA  EEA A GVD ++LDNM+ E + QA+ ++AGR+
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  246  ITEASGRVTPETATAIAESGVDLISVGWVTHSAAVLDIGL  285
              E SG +   T + +   ++D +S G +THSA  LD+++
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

286) nadC; SCE94.32c in NC_003888


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (602),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 111/274 (41%), Positives = 186/274 (68%), Gaps = 5/274 (1%)

Query  54   EVEDIANVAIQEDLAGGVDVTTVATIPEDAVATADFTAREAGVVAGLRVAEAVLSVVCTD  113
            +++D  + A++ED+ +  D +T A + +++ A   + A+EAGV+AGL V + V+++  ++
Sbjct  12   QIDDTLKAALREDVHSE-DYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  114  -EFEVERHVEDGDRVAEGQKLLSVTTRTRDILTAERSALNLLCRMSGIASATRAWADALD  172
              F+  ++  DGDR++ G+ +L +    R +LT ER ALN+L ++SGIAS T A  +AL+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  173  GTKAKVRDTRKTTPGLRGLEKFAVRCGGGVNHRMSLSDAALVKDNHVVAAGGVAEAFNAV  232
            + + KV DTRKTTP LR +EK+AVR GGG NHR +LSDA ++KDNH+ A G+V  A+   
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  233  R--ESFPEVPIEVEVDTLHQLREVVDAGADLILLDNFTPDECEEAVALVAGRAALEASGR  290
            R   +F  + +EVEV++L    E   AG D+I+LDN + ++ E+A++L+AGR+ +E SG 
Sbjct  191  RAYAPFVKM-VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  291  LTLTNAKAYAATGVDYLAVGALTHSSPILDIGLD  324
            + +T    + + ++DY++ G+LTHS+  LD+++ 
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

287) RUM_07150 in NC_021039


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (603),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 119/271 (44%), Positives = 178/271 (66%), Gaps = 2/271 (0%)

Query  8    IDDLIRRALAEDITYVDITTDTLMPDSHTSEAYYIAKDEGVLCGMDVALRVFDLAGGNV-  66
            IDD ++ AL ED+   D +T+++  +   +    +AK+ GVL G+ V  RVF L +++V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   -ETRALFHDGDKVCKGDILATMTGSTKTLLKGERTALNLLQHMSGIATATNRCVHLVEGT  125
             +    F DGD++  GD++  + GS ++LL  ER ALN+LQH+SGIA+ T   V+ + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  126  RARITDTRKTLPGMRALQKYAVVVGGGRNHRFNLSDGAMLKDNHLDAYGGITPAVAALRD  185
            R ++ DTRKT P +R ++KYAV VGGG NHRFNLSD+ MLKDNH+ A G++  A+A  R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  186  KIGHMVKIEVEVRNLEELQEALDAGCEIIMLDNMSCEDMAAAVQINAGRALLEASGNVTA  245
                +  +EVEV +L   +EA  AG +IIMLDNMS E++  A+ + AGR+ +E SGN+  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  246  ETIRPIAETGVDIISLGALTHSVKCFDISMR  276
             TI  +   ++D +S G+LTHS K +D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

288) nadC in NC_017038


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 120/281 (43%), Positives = 187/281 (67%), Gaps = 9/281 (3%)

Query  15   LPPWIIIDPWLQQWLAEDIGRGDWSTQGLGLQHRGQAR--WVAKENGVIAGLPMAARIFQ  72
            L P  I D  L+  L ED+   D ST+++ ++H+GQA+    AKE GV+AGL +  R+F 
Sbjct  8    LTPFQIDDT-LKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  73   LLDPSMEFQVLAG--EGQavtastvvatMAGNLGSLLTGERVALNLVMGLSGIATMTRQY  130
            L+D+ + FQ      +G+ +T++ +V  + G++ SLLT ERVALN++  LSGIA+MT  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  131  VQAIADYPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITK  190
            V+A++D   +  DTRKTTP LR++EKYA R+GG+ NHR+ L DA+M+KDNHI A GS+ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  191  AVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQANPLI  250
            A+   R   P+   +EVE  +L   +EA A+ V+IIMLDNM+ + +  A+ LI   +   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  251  RIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQ  291
            RIE SGN+ ++ ++ + + ++D++SS++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

289) nadC in NC_017052


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 120/281 (43%), Positives = 187/281 (67%), Gaps = 9/281 (3%)

Query  15   LPPWIIIDPWLQQWLAEDIGRGDWSTQGLGLQHRGQAR--WVAKENGVIAGLPMAARIFQ  72
            L P  I D  L+  L ED+   D ST+++ ++H+GQA+    AKE GV+AGL +  R+F 
Sbjct  8    LTPFQIDDT-LKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  73   LLDPSMEFQVLAG--EGQavtastvvatMAGNLGSLLTGERVALNLVMGLSGIATMTRQY  130
            L+D+ + FQ      +G+ +T++ +V  + G++ SLLT ERVALN++  LSGIA+MT  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  131  VQAIADYPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITK  190
            V+A++D   +  DTRKTTP LR++EKYA R+GG+ NHR+ L DA+M+KDNHI A GS+ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  191  AVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQANPLI  250
            A+   R   P+   +EVE  +L   +EA A+ V+IIMLDNM+ + +  A+ LI   +   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  251  RIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQ  291
            RIE SGN+ ++ ++ + + ++D++SS++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

290) nadC in NC_017039


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 120/281 (43%), Positives = 187/281 (67%), Gaps = 9/281 (3%)

Query  15   LPPWIIIDPWLQQWLAEDIGRGDWSTQGLGLQHRGQAR--WVAKENGVIAGLPMAARIFQ  72
            L P  I D  L+  L ED+   D ST+++ ++H+GQA+    AKE GV+AGL +  R+F 
Sbjct  8    LTPFQIDDT-LKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  73   LLDPSMEFQVLAG--EGQavtastvvatMAGNLGSLLTGERVALNLVMGLSGIATMTRQY  130
            L+D+ + FQ      +G+ +T++ +V  + G++ SLLT ERVALN++  LSGIA+MT  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  131  VQAIADYPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITK  190
            V+A++D   +  DTRKTTP LR++EKYA R+GG+ NHR+ L DA+M+KDNHI A GS+ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  191  AVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQANPLI  250
            A+   R   P+   +EVE  +L   +EA A+ V+IIMLDNM+ + +  A+ LI   +   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  251  RIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQ  291
            RIE SGN+ ++ ++ + + ++D++SS++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

291) nadC in NC_017277


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 120/281 (43%), Positives = 187/281 (67%), Gaps = 9/281 (3%)

Query  15   LPPWIIIDPWLQQWLAEDIGRGDWSTQGLGLQHRGQAR--WVAKENGVIAGLPMAARIFQ  72
            L P  I D  L+  L ED+   D ST+++ ++H+GQA+    AKE GV+AGL +  R+F 
Sbjct  8    LTPFQIDDT-LKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  73   LLDPSMEFQVLAG--EGQavtastvvatMAGNLGSLLTGERVALNLVMGLSGIATMTRQY  130
            L+D+ + FQ      +G+ +T++ +V  + G++ SLLT ERVALN++  LSGIA+MT  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  131  VQAIADYPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITK  190
            V+A++D   +  DTRKTTP LR++EKYA R+GG+ NHR+ L DA+M+KDNHI A GS+ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  191  AVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQANPLI  250
            A+   R   P+   +EVE  +L   +EA A+ V+IIMLDNM+ + +  A+ LI   +   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  251  RIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQ  291
            RIE SGN+ ++ ++ + + ++D++SS++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

292) nadC in NC_020286


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 120/281 (43%), Positives = 187/281 (67%), Gaps = 9/281 (3%)

Query  15   LPPWIIIDPWLQQWLAEDIGRGDWSTQGLGLQHRGQAR--WVAKENGVIAGLPMAARIFQ  72
            L P  I D  L+  L ED+   D ST+++ ++H+GQA+    AKE GV+AGL +  R+F 
Sbjct  8    LTPFQIDDT-LKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  73   LLDPSMEFQVLAG--EGQavtastvvatMAGNLGSLLTGERVALNLVMGLSGIATMTRQY  130
            L+D+ + FQ      +G+ +T++ +V  + G++ SLLT ERVALN++  LSGIA+MT  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  131  VQAIADYPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITK  190
            V+A++D   +  DTRKTTP LR++EKYA R+GG+ NHR+ L DA+M+KDNHI A GS+ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  191  AVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQANPLI  250
            A+   R   P+   +EVE  +L   +EA A+ V+IIMLDNM+ + +  A+ LI   +   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  251  RIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQ  291
            RIE SGN+ ++ ++ + + ++D++SS++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

293) nadC in NC_000911


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 120/281 (43%), Positives = 187/281 (67%), Gaps = 9/281 (3%)

Query  15   LPPWIIIDPWLQQWLAEDIGRGDWSTQGLGLQHRGQAR--WVAKENGVIAGLPMAARIFQ  72
            L P  I D  L+  L ED+   D ST+++ ++H+GQA+    AKE GV+AGL +  R+F 
Sbjct  8    LTPFQIDDT-LKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  73   LLDPSMEFQVLAG--EGQavtastvvatMAGNLGSLLTGERVALNLVMGLSGIATMTRQY  130
            L+D+ + FQ      +G+ +T++ +V  + G++ SLLT ERVALN++  LSGIA+MT  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  131  VQAIADYPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITK  190
            V+A++D   +  DTRKTTP LR++EKYA R+GG+ NHR+ L DA+M+KDNHI A GS+ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  191  AVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQANPLI  250
            A+   R   P+   +EVE  +L   +EA A+ V+IIMLDNM+ + +  A+ LI   +   
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---  242

Query  251  RIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQ  291
            RIE SGN+ ++ ++ + + ++D++SS++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

294) nadC in NC_013929


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  163 bits (604),  Expect = 9e-42, Method: Compositional matrix adjust.
 Identities = 113/273 (42%), Positives = 188/273 (69%), Gaps = 3/273 (1%)

Query  52   EVEDIANVALQEDLAHGVDVTTVATIPEDARATADFTAREGGVVAGLRIAEAVLSVACTD  111
            +++D  + AL+ED+ H+ D +T A + ++++A   + A+E+GV+AGL + + V+++  ++
Sbjct  12   QIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  112  -EFEVERHVDDGDSVEAGQKLLSVTGATRDLLTAERSALNLLCRLSGIATATRAWADALD  170
              F+  ++  DGD + +G+ +L + G+ R LLT ER ALN+L +LSGIA+ T A  +AL+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  171  GTKAKVRDTRKTTPGLRSLEKFAVRCGGGVNHRMSLSDAALVKDNHVVAAGGVAQAFEAV  230
            + + KV DTRKTTP LR +EK+AVR GGG NHR +LSDA ++KDNH+ A G+V +A+   
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  231  RAMFPEVP-VEVEVDTLHQLREVVDAGADLILLDNFTPVECEEAVALVDGRALLEASGRL  289
            RA  P V  VEVEV++L    E   AG D+I+LDN +  + E+A++L+ GR+ +E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  290  TLTNAKAYADTGVDFLAVGALTHSSPILDIGLD  322
             +T    + + ++D+++ G+LTHS+  LD+++ 
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

295) Haur_3382 in NC_009972


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (600),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 116/242 (48%), Positives = 162/242 (67%), Gaps = 3/242 (1%)

Query  52   AKAHVLVKDQGVLAGMDVAAAVCRLVDPALEWQPV--LGDGSAVEYGTIVAYLSGPARSV  109
            AK  ++ K+ GVLAG+ V   V  L D+ +  Q    + DG  +  G +V  + G+ RS+
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  110  LMAERTVLNFLQRLSGIASKTALYVAKIADTQAKLVDTRKTTPGWRALEKAAVRAGGGAN  169
            L  ER  LNFLQ+LSGIAS TA YV  ++D + K+ DTRKTTP  R +EK AVR GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  170  HRFNLGDGVLIKDNHLALGGHDIVGAIQRARAVAPHTTKIEVEVEDLAGVQAALEAGADI  229
            HRFNL+D++++KDNH+A  G  +  AI +ARA AP    +EVEVE LA+ + A  AG DI
Sbjct  162  HRFNLSDAIMLKDNHIAAVG-SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  230  IMLDNMSIEAMHEAVQLIAGRALVEASGGITLERIRAVAETGVNVISCGAITHSATALDI  289
            IMLDNMS+E +++A+ LIAGR+ +E SG I +  I      +++ +S G++THSA +LD+
Sbjct  221  IMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDF  280

Query  290  SL  291
            S+
Sbjct  281  SM  282

296) Amet_0019 in NC_009633


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (598),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 119/271 (44%), Positives = 184/271 (68%), Gaps = 2/271 (0%)

Query  7    IEDIIKNALIEDMNYGDITTDALVDGDKTGIAIITAKEEGVIAGTSIVEMVFKLVDQTLY  66
            I+D +K AL ED++  D +T+A+ D +  +   + AKE GV+AG ++ + VF L D  + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   VTNLKQ--DGEKVNTGDNMIEVDGNIKSILKGERIALNFMQRMSGIATTAREFADRVEGF  124
              N  Q  DG+++ +GD ++E+ G+++S+L  ER+ALNF+Q++SGIA+ +  + + + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  NTKIVDTRKTTPGLRSLEKYAVKVGGCYNHRFNLSDAVLIKDNHIKAVGGITEAVKRCRV  184
              K+ DTRKTTP LR +EKYAV+VGG YNHRFNLSDA+++KDNHI AVG++  A+ + R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  QIPHTAKievevesleqleeaievKADIIMLDNMTVEMMKEAVQRTKGRALLEASGNMTK  244
              P    +EVEVESL   EEA     DIIMLDNM++E + +A+    GR+ +E SGN+  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  EKIKEVAATGVDFISVGLLTHSVKAMDISLN  275
              I    + ++D++S G LTHS K++D+S++
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

297) nadC in NC_009848


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (599),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 116/276 (43%), Positives = 187/276 (68%), Gaps = 3/276 (1%)

Query  1    MERLQLKQMLTHFFAEDIGFGDVSADGIFGEK-KGTAYIIAKQSGVLAGSQVIDIGYRLL  59
            +  +Q+ + L   + ED+   D S+++IF++  ++   ++AK++GVLAG  V++  + L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   NEQI--QTELFFKEGEWVHSGAVLAKIKGPVSDLLKGERVILNVLQRMTGIATLTHEAVQ  117
            + ++  Q    FK+G+++ SG ++  I G+V  LL  ERV LN LQ+++GIA++T   V+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  118  RLADPSITICDTRKTTPGLRMLEKYAVKTGGGKNHRFGLSDGVMIKDNHIAACGSIREAV  177
             L+D  I + DTRKTTP LR++EKYAV+ GGG NHRF LSD++M+KDNHIAA GS++ A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  178  EKARAYAGHMVKIEVEIESETQLKEAIDAKADVIMFDNCSPDDVKRFKQMTPETILTEAS  237
             +ARAYA  +  +EVE+ES +   EA  A  D+IM+DN S +++ +   + +     E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  238  GGITLETLPSYRGTGVDLISLGFLTHSAPAFDFSMN  273
            G I + T++ +RG ++D +S G LTHSA ++DFSM+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

298) Oscil6304_1800 in NC_019693


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (599),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 121/283 (43%), Positives = 189/283 (67%), Gaps = 7/283 (2%)

Query  23   AALPPWIVLDPLFQGWLLEDIGRGDRTTSAIYIEEAPPGRAEWIVKEPGAVAGLPFARRI  82
            + L P  + D L ++ L ED+   D +T+AI+ ++   ++   + KE+G +AGL   +R+
Sbjct  6    TDLTPFQIDDTL-KAALREDVHSEDYSTNAIF-DHHGQAKVSLFAKEAGVLAGLTVFQRV  63

Query  83   FSLLDSAVEF--TPTIAEGEYCQPGQVVAQITGPVNALLTGERVALNLVMRLSGIATLTR  140
            F+L+D+ V F     + +G+   +G++V +I G+V +LLT ERVALN++ +LSGIA++T 
Sbjct  64   FTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTA  123

Query  141  KYVEKIADLPVQLVDTRKTTPGLRLLEKYATQVGGARNHRMGLDDAVMIKDNHivaaggi  200
             YVE ++D  +++ DTRKTTP LRL+EKYA +VGG+ NHR  L DA+M+KDNHI A G++
Sbjct  124  AYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSV  183

Query  201  gaaiarvrSQIPYPLTIEVETETINDVEEALEHGADIIMLDNMTVERMREAVPLIRQHND  260
              AIA+ R+  P+   +EVE E++   EEA   G DIIMLDNM++E++ +A+ LI    +
Sbjct  184  QKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AG  240

Query  261  RISIEASGNITLETIRAVGETGVDYISTSAPITRSTWLDLSMK  303
            R  IE SGNI + TI      ++DY+S+++    +  LD+SMK
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

299) PputW619_4407 in NC_010501


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (600),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 115/278 (42%), Positives = 195/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGDRATANQVLFHLEGPARSLLSGERSALNFLQMLSGVATRARAL  122
             +D+ V+ +   Q  DGDR T+ ++++++ G+ RSLL+ ER ALNFLQ LSG+A+ + A 
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVEGTQVQLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLFDAFLIKENHIAASGGVPE  182
             + + + +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AVAAAHRIAP-GKPVEIEVESLDELRQALSAGADIIMLDELSLDEMGEAVRITAGKAKLE  241
            A+A A+  AP  K VE+EVESL    +A +AG DIIMLD++SL+++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVTETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG +  TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

300) Mesau_05630 in NC_019973


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (600),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 113/279 (41%), Positives = 191/279 (69%), Gaps = 5/279 (1%)

Query  4    SPLPSTLIEPIVRGALLEDLGRCGDLTSDAVIPRDRTATLVLKSRQTGIVAGLDLAAFAF  63
            + L +  I+  +++AL ED+ +  D +++A++ ++  A + L ++++G++AGL +    F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   MLVEPAIDMQI---WRVDGSDVAGGEIIAMLCGPARGLLTAERTALNFLCHLSGIATATA  120
             L ++ +  Q     + DG  +++G+++  + G+ R+LLT ER ALNFL HLSGIA+ TA
Sbjct  65   TLFDAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTA  123

Query  121  AMVEAVRGHKARIVCTRKTTPGLRALEKYAVRVGGGANHRFGLDDAFLIKDNHIAIAGDI  180
            A VEA+ +++ ++  TRKTTP LR +EKYAVRVGGG NHRF L DA+++KDNHIA  G +
Sbjct  124  AYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSV  183

Query  181  RTTIEraraaaGHMVKIEVEVETLEQLDTALTLGVDAVLLDNMSVEDLARAVAMVGGRAI  240
            + +I +ARA A  +  +EVEVE+L   + A + GVD ++LDNMS+E++ +A+++++GR+ 
Sbjct  184  QKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  241  TEASGRVTPKMAPAIAATGVDLISVGWLTHSAPILDIGL  279
             E SG +     + + + ++D +S G LTHSA  LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

301) Mesci_5579 in NC_014923


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (600),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 113/279 (41%), Positives = 191/279 (69%), Gaps = 5/279 (1%)

Query  4    SPLPSTLIEPIVRGALLEDLGRCGDLTSDAVIPRDRTATLVLKSRQTGIVAGLDLAAFAF  63
            + L +  I+  +++AL ED+ +  D +++A++ ++  A + L ++++G++AGL +    F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   MLVEPAIDMQI---WRVDGSDVAGGEIIAMLCGPARGLLTAERTALNFLCHLSGIATATA  120
             L ++ +  Q     + DG  +++G+++  + G+ R+LLT ER ALNFL HLSGIA+ TA
Sbjct  65   TLFDAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTA  123

Query  121  AMVEAVRGHKARIVCTRKTTPGLRALEKYAVRVGGGANHRFGLDDAFLIKDNHIAIAGDI  180
            A VEA+ +++ ++  TRKTTP LR +EKYAVRVGGG NHRF L DA+++KDNHIA  G +
Sbjct  124  AYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSV  183

Query  181  RTTIEraraaaGHMVKIEVEVETLEQLDTALTLGVDAVLLDNMSVEDLARAVAMVGGRAI  240
            + +I +ARA A  +  +EVEVE+L   + A + GVD ++LDNMS+E++ +A+++++GR+ 
Sbjct  184  QKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  241  TEASGRVTPKMAPAIAATGVDLISVGWLTHSAPILDIGL  279
             E SG +     + + + ++D +S G LTHSA  LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

302) Mesop_6161 in NC_015675


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (600),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 113/279 (41%), Positives = 191/279 (69%), Gaps = 5/279 (1%)

Query  4    SPLPSTLIEPIVRGALLEDLGRCGDLTSDAVIPRDRTATLVLKSRQTGIVAGLDLAAFAF  63
            + L +  I+  +++AL ED+ +  D +++A++ ++  A + L ++++G++AGL +    F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   MLVEPAIDMQI---WRVDGSDVAGGEIIAMLCGPARGLLTAERTALNFLCHLSGIATATA  120
             L ++ +  Q     + DG  +++G+++  + G+ R+LLT ER ALNFL HLSGIA+ TA
Sbjct  65   TLFDAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTA  123

Query  121  AMVEAVRGHKARIVCTRKTTPGLRALEKYAVRVGGGANHRFGLDDAFLIKDNHIAIAGDI  180
            A VEA+ +++ ++  TRKTTP LR +EKYAVRVGGG NHRF L DA+++KDNHIA  G +
Sbjct  124  AYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSV  183

Query  181  RTTIEraraaaGHMVKIEVEVETLEQLDTALTLGVDAVLLDNMSVEDLARAVAMVGGRAI  240
            + +I +ARA A  +  +EVEVE+L   + A + GVD ++LDNMS+E++ +A+++++GR+ 
Sbjct  184  QKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  241  TEASGRVTPKMAPAIAATGVDLISVGWLTHSAPILDIGL  279
             E SG +     + + + ++D +S G LTHSA  LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

303) nadC in NC_004578


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (599),  Expect = 2e-41, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 200/278 (72%), Gaps = 5/278 (1%)

Query  7    ADLSA-EIEANVRRALLEDVGSGDITAQLIPAER-LAKATIISRDAAVIAGTAWVDTVFR  64
            +DL++ +I+  ++ AL EDV S D +++ I  ++  AK ++++++A+V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVVDGERVSPDQALFHLEGPARSLLTGERSALNFLQMLSGVATRAKYF  122
             +D+ V+ +   Q  DG+R+++++ ++++ G+ RSLLT ER ALNFLQ LSG+A+ +  +
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADIVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIAQ  182
             + +++ ++K++DTRKT P LR+ +KYAV  GG  NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AVTAAHRIAP-GKPVEVEVESLGELKQALDAGADIVMLDELSLDDMREAVRLTAGRALLE  241
            A++ A+  AP  K VEVEVESL+   +A  AG DI+MLD++SL+++ +A+ L AGR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINDDTLRVIADTGVDYISIGAMTKDVKAVDLSMR  279
             SG I+  T+  + + ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

304) nadC in NC_008384


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (598),  Expect = 3e-41, Method: Compositional matrix adjust.
 Identities = 111/260 (43%), Positives = 178/260 (69%), Gaps = 5/260 (1%)

Query  32   ITSAAVIPRDHRSTVVMAARQPGVIAGLDAAELAFALVDPEIVMR--RHLQDGDAVKPGD  89
             ++ A++ ++ ++ V + A+++GV+AGL   +  F+L D+E+  +  ++++DGD + +GD
Sbjct  30   YSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGD  89

Query  90   VIATIEGPSRGLLSAERTALNFLGHLSGiatvtaqiaaaiRGTRASVACTRKTTPGLRSL  149
            ++  I G+ R+LL+ ER ALNFL HLSGIA++TA    A+ + R  V  TRKTTP LR +
Sbjct  90   LVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLF  149

Query  150  EKYAVRAGGGMNHRFALYDAVLIKDNHVAIAGGVTEAIRRARAGVGHMVKIEVEVDTLDQ  209
            EKYAVR GGG NHRF L DA+++KDNH+A  G+V  AI +ARA    +  +EVEV++L  
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAA  209

Query  210  LCEAMETGVDAVLLDNMTPDQLREAVAIVAGRAITEASGRVTPMTAAAIAASGVDLISVG  269
              EA  +GVD ++LDNM+ +Q+ +A++++AGR+  E SG +   T + + + ++D +S G
Sbjct  210  AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  270  WLTHSAPVLDI---GLDFVE  286
             LTHSA  LD+   GL +++
Sbjct  270  SLTHSAKSLDFSMKGLTYLD  289

305) nadC in NC_017030


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (597),  Expect = 3e-41, Method: Compositional matrix adjust.
 Identities = 107/257 (42%), Positives = 175/257 (69%), Gaps = 3/257 (1%)

Query  21   AGDVTSLAVVPAEAEGSGELVAKEQMIVAGLDAFVRVFHMVDAEVEVQVLK--RDGEEIK  78
            + D ++ A+   ++++   L AKE  ++AGL  F RVF + DAEV  Q     +DG+ + 
Sbjct  27   SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLT  86

Query  79   PKVVAARVHGKLRSLLAAERTALNLVQRAAGIATLAQQAMTSVRGSKLRVLDTRKTPPGM  138
            +  +   + G +RSLL+ ER ALN++Q+ +GIA+++   + ++ + +++V+DTRKT P +
Sbjct  87   SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNL  146

Query  139  RGLAKHAVRMGGASNHRFGLFDGILIKDNHIAAVGGDITEAVRRAKLNGPRLVKIEVEVT  198
            R + K AVR+GG+ NHRF L D+I++KDNHIAAVG+ +  A+ +A+  +P +  +EVEV 
Sbjct  147  RLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS-VQKAIAQARAYAPFVKMVEVEVE  205

Query  199  NFKQLEEALAAGADVIMLDNMDDAQIREAVKLTANRVPIEVSGGVTLDRLPRLAKLGVDF  258
            ++   EEA AAG D+IMLDNM   QI +A+ L A R  IE SG + +  ++R+  L++D+
Sbjct  206  SLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDY  265

Query  259  VSMGALTHSARAMDLSL  275
            VS G+LTHSA+++D+S+
Sbjct  266  VSSGSLTHSAKSLDFSM  282

306) GTNG_2530 in NC_009328


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  162 bits (597),  Expect = 3e-41, Method: Compositional matrix adjust.
 Identities = 110/274 (41%), Positives = 182/274 (67%), Gaps = 2/274 (0%)

Query  1    MNRLKLEQLLRQFFLEDIGDGDVTSDTIFPANERATGVFTAKEDGVVAGVDLIAAGYQLL  60
            +  +++++ L+  + ED+   D ++++IF  + +A   + AKE GV+AG+ ++   + L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DPHIEVSIMK--RDGERIAAGETIAAVSGPVRPLLSGERVILNLLQRLSGIATMTRQAVD  118
            D+++        +DG+R+++G+ +  + G+VR+LL+ ERV LN+LQ+LSGIA+MT   V+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  LLGDSHTRLCDTRKTTPGLRMLEKYAVTCGGGYNHRFGLYDGVMIKDNHIAFCGSIAAAV  178
             LGD + ++ DTRKTTP LR++EKYAV  GGGYNHRF L D++M+KDNHIA  GS+  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  KAVRERLGHMVKIEVETETEAQVLEAVEAGADIIMFDNRTPDEVRSFVRLVPKPIITEAS  238
               R     +  +EVE E+ A   EA  AG DIIM+DN + +++   + L++     E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGITLANVAAYGATGVDYISLGFLTHSAAALDIS  272
            G I ++ ++ + + ++DY+S G LTHSA +LD+S
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

307) Desku_3227 in NC_015573


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  161 bits (596),  Expect = 3e-41, Method: Compositional matrix adjust.
 Identities = 125/270 (47%), Positives = 189/270 (70%), Gaps = 2/270 (0%)

Query  6    LEDLIDRVLKEDIGTGDVTTNSIVPPDYTTIGFIHAKEpgvvaglpvagavFRRLSPHIS  65
            ++D +   L+ED+ + D +TN+I   +  +   + AKE+GV+AGL V   VF  + ++++
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   FQI--RVREGERVQAGQLLARVEGEARAILSGERVALNLLQRMSGIATYTARLVELIREF  123
            FQ   + ++G+R+ +G+L+  + G  R++L+ ERVALN+LQ++SGIA+ TA  VE + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  124  KAKIVDTRKTTPGLRILEKYAVRVGGALNHRFGLYDAVLIKDNHIKVAGSITRAVELARA  183
            + K+ DTRKTTP LR++EKYAVRVGG+ NHRF L DA+++KDNHI   GS+ +A+  ARA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  184  NIPHTMKVEVEVEDLTGVEEALAAGADIIMLDNMDIPTMTRAVELAAGRAYLEASGRINE  243
              P    VEVEVE L++ EEA AAG DIIMLDNM +  + +A+ L AGR+ +E SG I+ 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  244  QNIVEVARTGVDFISLGALTHSARSLDISL  273
              I      ++D++S G+LTHSA+SLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

308) Calkr_1195 in NC_014721


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  161 bits (595),  Expect = 4e-41, Method: Compositional matrix adjust.
 Identities = 114/270 (43%), Positives = 184/270 (69%), Gaps = 2/270 (0%)

Query  7    IDKIIKDALVEDMPYGDVTTQLLIPQESISSAVFLSKENGILCGIDVAKRVFEILDSNIK  66
            ID  +K AL ED+   D +T+ ++ +++ +   +++KE G+L G+ V +RVF ++D+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLK--TDGDYIQKGDVLAKIQGNTRAILMGERLALNLLQRMSGIATFTNMLAQKIKGY  124
            F++     DGD +  GD++  I G+ R++L  ER+ALN+LQ++SGIA+ T    + + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  KATVTDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKAVGSITEAVKRAKE  184
            +  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI AVGS+  A+ +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NVPHTMKVEVEVRNMQEFEEALLSGADIIMLDHFTVDEMKKAVEKAEGRVLIEASGNINI  244
              P    VEVEV ++   EEA  +G DIIMLD+ +++++ +A+    GR  IE SGNI++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DNIEEIAKTGVDIISVGSITHSVKSLDISL  274
              I  +   ++D +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

309) Plav_0732 in NC_009719


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  161 bits (595),  Expect = 4e-41, Method: Compositional matrix adjust.
 Identities = 116/283 (41%), Positives = 187/283 (67%), Gaps = 3/283 (1%)

Query  1    MTLQLTPLPALMIEPAVRAALAEDLGRAGDITTQATVPAEAKARVLINARQPGRVAGLDC  60
            M++  T L ++ I+ +++AAL ED+ ++ D +T+A    +++A+V + A+++G +AGL  
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   ARMAFRLVDPSLKVAVVKA--DGSDVEPGDTIAAIEGPARGILTGERVALNFLGHMSGIA  118
             +  F L D+ +         DG  + +GD +  I G+ R++LT ERVALNFL H+SGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  TSTREIARAIEGTKAHVCCTRKTTPGLRIFEKYAVRAGGGMNHRFGLDDAVLIKDNHIAM  178
            + T     A+ + +  V  TRKTTP LR+FEKYAVR GGG NHRF L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  SGGIEAAISRAKAASGHMVKIEVEVDTLDQLDQALAVGVDAVLLDNMTPEMLTEAVRRIG  238
             G+++ AI++A+A +  +  +EVEV++L   ++A A GVD ++LDNM+ E + +A+  I+
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  GRAVAEASGRitaatapaiaaSGVDLISCGWITHSAPCLDVGL  281
            GR+  E SG I  +T + + + ++D +S G +THSA  LD ++
Sbjct  240  GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

310) nadC in NC_010998


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  161 bits (594),  Expect = 5e-41, Method: Compositional matrix adjust.
 Identities = 111/253 (44%), Positives = 175/253 (70%), Gaps = 2/253 (0%)

Query  29   ITSAAVIPGEHRSTVMMAARQPGVIAGLDAAELAFTLVDPEIVMR--RHIEDGDAVKTGD  86
             ++ A++  + ++ V + A+++GV+AGL   +  FTL D+E+  +  +++ DGD + +GD
Sbjct  30   YSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGD  89

Query  87   VIATIEGPSRGLLTAERTALNFLGHLSGiatvtaeiaaaiSGSKASVACTRKTTPGLRAL  146
            ++  I G+ R+LLT ER ALNFL HLSGIA++TA    A+++ +  V  TRKTTP LR +
Sbjct  90   LVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLF  149

Query  147  EKYAVRAGGGMNHRFALYDAVLIKDNHVAISGGVAEAIRRARAGVGHLVKVEVEVDRLDQ  206
            EKYAVR GGG NHRF L DA+++KDNH+A  G+V  AI +ARA    +  VEVEV+ L  
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAA  209

Query  207  LHEAMETGVDAVLLDNMTPDQLREAVAIVAGRAITEASGRVMPATAAAIAASGVDLISVG  266
             +EA  +GVD ++LDNM+ +Q+ +A++++AGR+  E SG +  +T + + + ++D +S G
Sbjct  210  AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  267  WLTHSAPVLDIGL  279
             LTHSA  LD+++
Sbjct  270  SLTHSAKSLDFSM  282

311) nadC in NC_016640


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  161 bits (594),  Expect = 6e-41, Method: Compositional matrix adjust.
 Identities = 118/281 (42%), Positives = 183/281 (66%), Gaps = 7/281 (2%)

Query  9    LPPWIVLDPLLKQWLTEDIGRGDRTTDGLLRGENLWGTAHWEAKAPGIVAGLPVAARVFQ  68
            L P  + D  LK  L ED+   D +T++++  +     +   AK +G++AGL V  RVF 
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLF-AKEAGVLAGLTVFQRVFT  65

Query  69   LLSD--RLQVKPTVKDGDQCDRGQVILQLEGPLDALLMGERVALNLAMRLSGVATSTGEY  126
            L+     +Q     KDGD+   G+++L++ G++ +LL  ERVALN+  +LSG+A+ T+ Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  127  VDAIADLPTQLVDTRKTTPGLRLLEKYAIQVGGAKNHRMGLDDAVLIKDNHILAAGGIEK  186
            V+A++D   ++ DTRKTTP LRL+EKYA++VGG+ NHR  L DA+++KDNHI A G+++K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  187  AIALIRETMPYPLtievetetieqvktAVNAGADIIMLDNMSLAMMQEAIEIIRQYNSRI  246
            AIA  R   P+   +EVE E++     A  AG DIIMLDNMSL  +++AI +I    +R 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  247  KIEASGNITLQTIRQVAEIGVDYISTSATITRSPWLDISMN  287
            +IE SGNI + TI +   +++DY+S+++    +  LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

312) nadC in NC_011297


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (589),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 120/277 (44%), Positives = 187/277 (68%), Gaps = 3/277 (1%)

Query  5    PYLHLKKIVEEALEEDIGFGDITTESIVPEDMNSKAVIIAKEEGILAGLPVAKAVFKTLE  64
            P+ ++   +  AL ED+   D +T++I  ++ ++K  ++AKE G+LAGL V + VF  ++
Sbjct  10   PF-QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  65   SSVEFkelkk--dgdkikegdiilEIIGKTKTILMGERTALNFIQRLSGIATYTRKCVDM  122
            + V F++  +  DGD++  GD++LEIIG  +++L  ER ALNF+Q+LSGIA+ T   V+ 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  123  VRPYGVKILDTRKTTPTLRILEKYAVKIGGGENHRFALYDMVLIKDNHIRVAGSIKEAIR  182
            +    +K++DTRKTTP LR++EKYAV++GGG NHRF L D +++KDNHI   GS++ AI 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  183  RVRENVSHVYKIEVEVSNLEELKEALETQVDIVLLDNMDYETLKEAINMAKGKVLIEVSG  242
            + R   + V  +EVEV +L    EA  + VDI++LDNM  E + +AI +  G+  IE SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  243  KISMEDLEKIAKLGVDFISMGKLTHSFKSLDLSLEIL  279
            +I M  + ++  L++D++S G LTHS KSLD+S+  L
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

313) Rleg_7190 in NC_012858


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (589),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 111/260 (43%), Positives = 179/260 (69%), Gaps = 5/260 (1%)

Query  29   ITSASVIPRDHRSTVVMAARQPGVIAGLDAAELAFSLVDPEIVMRRHRQ--DGDAVKAGD  86
             ++ +++ ++ ++ V + A+++GV+AGL   +  F+L D+E+  +  +Q  DGD + +GD
Sbjct  30   YSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGD  89

Query  87   VIATIEGPSRGLLSAERTALNFLGHLSgiatvtagiaaairgtkaSVACTRKTTPGLRAL  146
            ++  I G+ R+LL+ ER ALNFL HLSGIA++TA+   A+ + +  V  TRKTTP LR +
Sbjct  90   LVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLF  149

Query  147  EKYAVRAGGGMNHRFALYDAVLIKDNHVAIAGGVTEAIRRARAGVGHMVKIEVEVDTLDQ  206
            EKYAVR GGG NHRF L DA+++KDNH+A  G+V  AI +ARA    +  +EVEV++L  
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAA  209

Query  207  LREAIETGVDAVLLDNMTLNELREAVAIVAGRAITEASGRVTPTTAAAIAASGVDLISVG  266
              EA  +GVD ++LDNM+L+++ +A++++AGR+  E SG +  TT + + + ++D +S G
Sbjct  210  AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  267  WLTHSAPVLDI---GLDFVE  283
             LTHSA  LD+   GL +++
Sbjct  270  SLTHSAKSLDFSMKGLTYLD  289

314) M062_23805 in NC_021577


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (589),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 189/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLLQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + +++L++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TTVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGidraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EGTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
              T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

315) nadC in NC_013891


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (589),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 113/279 (41%), Positives = 196/279 (71%), Gaps = 4/279 (1%)

Query  1    MNPLLINQAIQAFLVEDIGQHDLTADSIFGNDILGEGVFLAKETGVVCGVEIPGKTYQFL  60
            + P+ I+++++A L ED+  +D ++++IF+++  +   ++AKE+GV+ G+ +  + + ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   GGEIDY-KPYK-KDGDLVQAGDIIGVVTAPVRTLLSAERVILNLMQRMSGIATQTNFAIK  118
            ++E+ + +P + KDGD + +GD++  + ++VR+LL+ ERV LN++Q++SGIA+ T   + 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  QLDDPTIRICDTRKTAPGLRAFDKHAVQTGGGFNHRNGLYDGVMLKDNHIAFSGGITAAI  178
             L+D  I++ DTRKT+P LR F+K AV+ GGG+NHR  L D++MLKDNHIA  G++  AI
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  SSVRAKLGHMVKIevetetaqqvteavqaGADIIMFDNRTPEEINQLVKLVPDHITTEAS  238
            +  RA    +  +EVE E+     EA  AG DIIM+DN + E+I+Q + L++++   E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNITLENIARFKGCGVNYISLGALTHSVNALDISFNSKG  277
            GNI +  I+RF+G +++Y+S G+LTHS ++LD  F+ KG
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD--FSMKG  284

316) nadC in NC_011959


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (589),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 107/262 (41%), Positives = 183/262 (70%), Gaps = 2/262 (0%)

Query  71   LREDLGYGDRTTLAVVSPGATGTAAIVMRQPGVLCGMPVIEAVFA--ELDTRLRVTTMCR  128
            LRED+   D +T A+    + +  ++  +++GVL G+ V++ VF+  + +  ++     +
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  129  EGELVPEGTVVGQVVGPLRGILAGERLALNLLQRLSGIATLTRRFVDAVAGTGVMILDTR  188
            +G+ +  G +V +++G++R++L+ ER+ALN+LQ+LSGIA++T  +V+A+++  + ++DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  189  KTTPGLRLLEKYAVRVGGGRNHRFGLFDGVLIKDNHVRVAGSVREAVQRVRNVIPHtmlv  248
            KTTP LRL+EKYAVRVGGG NHRF L D++++KDNH+   GSV+ A+ + R   P   +V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  249  evevttleeldealaaGADWILLDNMDVETMREAVRRVAGRAKLEASGGVTLERVRAIAE  308
            EVEV +L   +EA AAG D I+LDNM +E + +A+  +AGR+++E SG + +  +  +  
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  309  TGVDAISVGALTHSASALDISL  330
             ++D +S G+LTHSA +LD+S+
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSM  282

317) Ethha_0040 in NC_014828


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 126/274 (46%), Positives = 184/274 (68%), Gaps = 2/274 (0%)

Query  4    PMHYDEVILRGLKEDINYIDVTTDNLIPEEQQSGAVFLAKEDGVLCGLDVALRTLRLLDA  63
            P + D+ +  +L+ED++  D +T+ ++ ++ Q+   ++AKE GVL GL V  R + L+DA
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  64   GVTAEVLR--KDGDMLQKGEIIARVHGNTRALLKGERTALNLLQHLSGIATATARAVQTV  121
             VT +  +  KDGD L  G+++  + G+ R+LL  ER ALN+LQHLSGIA+ TA  V+++
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  122  EGTCASVCDTRKTLPGLRVLEKYAVTVGGGKNHRFNLSDAALIKDNHVDAAGGIGKAVAT  181
             +    V DTRKT P LR++EKYAV VGGG NHRFNLSDA ++KDNH+ A G++ KA+A 
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  182  LRARVGHTVKIEVETRdlkeladalaagadiimldNMSLEDMREAVRVTAGRVPLEASGG  241
             RA       +EVE   L    +A AAG DIIMLDNMSLE++ +A+ + AGR  +E SG 
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  242  VTQETLRGIAETGVNLISIGALTHSVKALDISMK  275
            +   T+  +   +++ +S G+LTHS K+LD+SMK
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

318) nadC in NC_014532


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 113/263 (43%), Positives = 184/263 (70%), Gaps = 4/263 (1%)

Query  33   LAEDVGPGDITAELIAEKQ-WARARVITREDTVLCGVAWVDELFRRLDPRVSLH--WQAA  89
            L EDV + D +++ I + +  A+  ++++E  VL G++  + +F  +D+ V+++   Q  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  90   DGDRLSAGQAFLELEGPARSLLTGERAALNLLQTLSGTATRTRHYVDLLAGTGVRMLDTR  149
            DGDRL++G+  LE+ G+ RSLLT ER ALN+LQ LSG A+ T  YV+ L++  ++++DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  150  KTLPGLRLAQKYAVSCGGGHNHRIGLYDAFLIKENHIASCGGIAAAVKEARDIARDLP-V  208
            KT P LRL +KYAV  GGG NHR+ L DA+++K+NHIA+ G++  A+ +AR  A  +  V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  209  EVEVENFDELDQALEAGADVIMLDNFSLDDLREAVRRTAGRATLEASGNVDESTLKAIAD  268
            EVEVE++   ++A  AG D+IMLDN SL+++ +A+   AGR+ +E SGN+D +T+  + +
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  269  TGVDCISSGALTKDVKAIDLSMR  291
             ++D +SSG+LT   K++D+SM+
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSMK  283

319) Cycma_1124 in NC_015914


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 119/289 (42%), Positives = 185/289 (65%), Gaps = 11/289 (3%)

Query  5    ITAEGLNQF-----IDAALKEDVGVGDHSTLASVPADQQGKANLLIKEKGIIAGLTLAER  59
            I + +L  F     + AAL+EDV   D ST A    + Q+K +L+ KE G++AGLT+ +R
Sbjct  3    IISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  60   IFSHFDPNLTVN--LLMNDGDAVNYGDIGLTVSGSAQSILTTERLVLNCMQRMSGIATKT  117
            +F+ FD+++T +     +DGD +  GD+ L + GS +S+LT ER+ LN +Q++SGIA+ T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  118  HHFNQLIQHTDARLLDTRKTTPNFRMLEKWAVAIGGGQNHRYALYDMIMLKDNHIDFAGG  177
              + + + +   +++DTRKTTPN+R++EK AV +GGG NHR+ L D IMLKDNHI   G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  178  IAEAINATNAYLKKNRLDLKVEIETRNLKEVKAVLDKGGVDIIMLDNMSPKEMKEAVALI  237
            +  AI  + AY    ++   VE+E  +L         +GVDIIMLDNMS  ++ +A++LI
Sbjct  183  VQKAIAQARAYAPFVKM---VEVEVESLAAAEEA-AAAGVDIIMLDNMSLEQIEQAITLI  238

Query  238  DKQYITEASGGINENTIVDVAESGVDFISVGALTHQVQSLDISLKAVKY  286
              +   E SG I+  TI      ++D++S G+LTH  +SLD+S+K++ Y
Sbjct  239  AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTY  287

320) nadC in NC_003047


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 119/297 (41%), Positives = 198/297 (67%), Gaps = 17/297 (5%)

Query  1    MTALRPELPALMVEEQVKAALLEDLGRAGDITTLSTIGPDRTAAANMSVREAGVVAGLEL  60
            M+ +  +L ++ +++ +KAAL ED+ ++ D +T + ++ +  A  ++  +EAGV+AGL +
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   ARTAFRLIDPSIRFEALAA--DGDRVAPGTTVARISGRARGLLSAERVALNFLMHLSGIA  118
             +  F L+D+ + F+      DGDR+++G  V  I G  R+LL+ ERVALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  TYTATFADEIAHTGAKVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIav  178
            + TA++ + +++   KV  TRKT P LR +EKYAVR+GGG NHR+ L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  sggvagavraaraYCGHLVKVEVEVDGLAQLREALTASPDVVLLDNMGPELLSEAVAINA  238
             G+V  A+  ARAY   +  VEVEV++LA   EA +A+ D+++LDNM+ E + +A+++ A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  AHWGLSVASYPGDLRRTRLEASGNVQIETIRAIAETGVDYISTSKITMAAPTLDIGL  295
            +              R+R+E SGN+++ TI  +   ++DY+S++ +T +A +LD+++
Sbjct  240  G--------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

321) nadC in NC_020528


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 119/297 (41%), Positives = 198/297 (67%), Gaps = 17/297 (5%)

Query  1    MTALRPELPALMVEEQVKAALLEDLGRAGDITTLSTIGPDRTAAANMSVREAGVVAGLEL  60
            M+ +  +L ++ +++ +KAAL ED+ ++ D +T + ++ +  A  ++  +EAGV+AGL +
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   ARTAFRLIDPSIRFEALAA--DGDRVAPGTTVARISGRARGLLSAERVALNFLMHLSGIA  118
             +  F L+D+ + F+      DGDR+++G  V  I G  R+LL+ ERVALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  TYTATFADEIAHTGAKVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIav  178
            + TA++ + +++   KV  TRKT P LR +EKYAVR+GGG NHR+ L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  sggvagavraaraYCGHLVKVEVEVDGLAQLREALTASPDVVLLDNMGPELLSEAVAINA  238
             G+V  A+  ARAY   +  VEVEV++LA   EA +A+ D+++LDNM+ E + +A+++ A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  AHWGLSVASYPGDLRRTRLEASGNVQIETIRAIAETGVDYISTSKITMAAPTLDIGL  295
            +              R+R+E SGN+++ TI  +   ++DY+S++ +T +A +LD+++
Sbjct  240  G--------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

322) SinmeB_0718 in NC_017322


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 119/297 (41%), Positives = 198/297 (67%), Gaps = 17/297 (5%)

Query  1    MTALRPELPALMVEEQVKAALLEDLGRAGDITTLSTIGPDRTAAANMSVREAGVVAGLEL  60
            M+ +  +L ++ +++ +KAAL ED+ ++ D +T + ++ +  A  ++  +EAGV+AGL +
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   ARTAFRLIDPSIRFEALAA--DGDRVAPGTTVARISGRARGLLSAERVALNFLMHLSGIA  118
             +  F L+D+ + F+      DGDR+++G  V  I G  R+LL+ ERVALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  TYTATFADEIAHTGAKVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIav  178
            + TA++ + +++   KV  TRKT P LR +EKYAVR+GGG NHR+ L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  sggvagavraaraYCGHLVKVEVEVDGLAQLREALTASPDVVLLDNMGPELLSEAVAINA  238
             G+V  A+  ARAY   +  VEVEV++LA   EA +A+ D+++LDNM+ E + +A+++ A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  AHWGLSVASYPGDLRRTRLEASGNVQIETIRAIAETGVDYISTSKITMAAPTLDIGL  295
            +              R+R+E SGN+++ TI  +   ++DY+S++ +T +A +LD+++
Sbjct  240  G--------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

323) C770_GR4Chr1104 in NC_019845


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 119/297 (41%), Positives = 198/297 (67%), Gaps = 17/297 (5%)

Query  1    MTALRPELPALMVEEQVKAALLEDLGRAGDITTLSTIGPDRTAAANMSVREAGVVAGLEL  60
            M+ +  +L ++ +++ +KAAL ED+ ++ D +T + ++ +  A  ++  +EAGV+AGL +
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   ARTAFRLIDPSIRFEALAA--DGDRVAPGTTVARISGRARGLLSAERVALNFLMHLSGIA  118
             +  F L+D+ + F+      DGDR+++G  V  I G  R+LL+ ERVALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  TYTATFADEIAHTGAKVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIav  178
            + TA++ + +++   KV  TRKT P LR +EKYAVR+GGG NHR+ L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  sggvagavraaraYCGHLVKVEVEVDGLAQLREALTASPDVVLLDNMGPELLSEAVAINA  238
             G+V  A+  ARAY   +  VEVEV++LA   EA +A+ D+++LDNM+ E + +A+++ A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  AHWGLSVASYPGDLRRTRLEASGNVQIETIRAIAETGVDYISTSKITMAAPTLDIGL  295
            +              R+R+E SGN+++ TI  +   ++DY+S++ +T +A +LD+++
Sbjct  240  G--------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

324) nadC in NC_017325


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (592),  Expect = 7e-41, Method: Compositional matrix adjust.
 Identities = 119/297 (41%), Positives = 198/297 (67%), Gaps = 17/297 (5%)

Query  1    MTALRPELPALMVEEQVKAALLEDLGRAGDITTLSTIGPDRTAAANMSVREAGVVAGLEL  60
            M+ +  +L ++ +++ +KAAL ED+ ++ D +T + ++ +  A  ++  +EAGV+AGL +
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   ARTAFRLIDPSIRFEALAA--DGDRVAPGTTVARISGRARGLLSAERVALNFLMHLSGIA  118
             +  F L+D+ + F+      DGDR+++G  V  I G  R+LL+ ERVALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  TYTATFADEIAHTGAKVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIav  178
            + TA++ + +++   KV  TRKT P LR +EKYAVR+GGG NHR+ L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  sggvagavraaraYCGHLVKVEVEVDGLAQLREALTASPDVVLLDNMGPELLSEAVAINA  238
             G+V  A+  ARAY   +  VEVEV++LA   EA +A+ D+++LDNM+ E + +A+++ A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  AHWGLSVASYPGDLRRTRLEASGNVQIETIRAIAETGVDYISTSKITMAAPTLDIGL  295
            +              R+R+E SGN+++ TI  +   ++DY+S++ +T +A +LD+++
Sbjct  240  G--------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

325) nadC in NC_011144


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (591),  Expect = 8e-41, Method: Compositional matrix adjust.
 Identities = 101/219 (47%), Positives = 157/219 (72%), Gaps = 2/219 (0%)

Query  65   LDPALAFE-PH-VRDGDVVPAGAVLAAVQGKARAILSAERTALNLLGRLCGIATLTQDYV  122
            +D+ ++F+ PH  +DGD + +G ++  + G  R++L+ ER ALN+L +L GIA++T  YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  123  DAVAGTGARITDTRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGSVGEA  182
            +A+++   ++ DTRKTTP LR +EKYAVR GGG NHRF L DAI++KDNH+AA GSV  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  183  VRRAKAYAGHLMKVEVEVDNLVQFHEALAADPDVVMLDNFSLADMAEAVRLGKGRVVLEA  242
            + +A+AYA  +  VEVEV++L   +EA AA+ D++MLDN SL ++ +A+ L  GR  +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  243  SGGVTLETVRAIAETGVDVISVGALTHSAKVLDIGLDAV  281
            SG + + T+  +   ++D +S G+LTHSAK LD+++ ++
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

326) mll9102 in NC_002679


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (591),  Expect = 8e-41, Method: Compositional matrix adjust.
 Identities = 123/283 (44%), Positives = 190/283 (68%), Gaps = 6/283 (2%)

Query  4    APLPAIMLEPLVRAALLEDLGRAGDLTTDAIVPKDLRATTVLSARQTGVVAGLDLAILAF  63
            + L ++ ++  ++AAL ED+ ++ D +T+AI   + +A   L A+++GV+AGL +    F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   RLIDERI--ETTPVCPDGSEVTPGQTIALVSGPARAILTAERTALNFLSHLSGIATATAS  121
             L+D  +  +      DG  +T+G+ +  + G+ R++LT ER ALNFL HLSGIA+ TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  122  IVNAIRDHKAKIVCTRKTTPGLRAVEKYAVRAGGGGNHRFGLDDAILIKDNHIAMAGGIR  181
             V+A+ D++ K+  TRKTTP LR  EKYAVR GGG NHRF L DAI++KDNHIA  G+++
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  PAIERTRASVGHLIKIEVEVDTlaqleealalapdavlldNMSLDELRHAVSMVAGRCIT  241
             AI ++RA    +  +EVEV++LA  EEA A + D ++LDNMSL+++ +A++++AGR   
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  242  EASGRITTSTVPAVAATGVDLISIGWLTHSAPILDI---GLDY  281
            E SG I  +T++   + ++D +S G LTHSA  LD+   GL Y
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTY  287

327) Niako_6865 in NC_016609


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  160 bits (591),  Expect = 8e-41, Method: Compositional matrix adjust.
 Identities = 117/274 (43%), Positives = 178/274 (65%), Gaps = 8/274 (2%)

Query  12   IEAALHEDIGDGDHSTLSAIPADARGKAVLKIKQAGTIAGMQVAEAIFRYKEPGARFIA-  70
            + AAL+ED+   D ST + +  ++++K  L  K+AG +AG+ V + +F   ++   F   
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  71   --FKKDGDTMLPGENAFEVIATVHTILQCERLVLNCMQRMSGIATLTRQYTDQLKGYATK  128
              FK DGD + +G+  +E+I++V+++L CER+ LN +Q++SGIA++T  Y + L +   K
Sbjct  77   HQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  129  LLDTRKTTPGFRLLEKEAVRIGGGHNHRMGLYDMIMLKDNHIDYCGGLEKAIERAWEYVQ  188
            ++DTRKTTP +RL+EK AVR+GGG NHR  L D IMLKDNHI   G+++KAI +A+ Y  
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  189  QVKPGLKIEVETRSLDDVKRVVAFGKVDRIMLDNFTPQQLSQALKIINGQYETEASGGIT  248
             VK    +EVE  SL       A G VD IMLDN + +Q+ QA+ +I G+   E SG I 
Sbjct  196  FVK---MVEVEVESLAAAEEAAAAG-VDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  LENITEYAQTGVDYVSVGALIHQAVSLDLSLKAV  282
            +  I+ +   ++DYVS G+L H A SLD+S+K++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

328) nadC in NC_014550


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (588),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 111/266 (42%), Positives = 180/266 (68%), Gaps = 5/266 (1%)

Query  20   ALAEDNPRGDITALTIVAQDARATAVVKARQPGVLSGGDVFTRTMHLVDAQLEVE--QLI  77
            AL ED    D ++ +I  ++++A   + A+++GVL+G  VF R   L DA++  +  + +
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  78   PEGEKFEAGDDLLKVTGPAASLLTAERVGLNLLQRMSAIATATAQLVDLVAHTKARIVDT  137
             +G+++ +GD +L + G+  SLLT ERV+LN+LQ++S+IA+ TA  V+ +++ + ++ DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  138  RKTTPGLRVLERYAVRCGGGVNHRDNLSDAFMAKDNHLALLDNGEQLTAALKSVRARLGH  197
            RKTTP LR++E+YAVR GGG NHR NLSDA+M KDNH+A +++ ++   A+   RA    
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK---AIAQARAYAPF  196

Query  198  TTSMEVEVDSIEQIPPVLAAGVDIIMLDNFDPADIPAAIELIDGQAVVEASGNINASTVV  257
               +EVEV+S+       AAGVDIIMLDN    +I  AI LI G++ +E SGNI+ +T+ 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  258  AVAEAGVDVISSGAITHSVKAIDLGL  283
                 ++D +SSG++THS K++D+++
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSM  282

329) Pden_4430 in NC_008687


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (588),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 110/267 (42%), Positives = 180/267 (68%), Gaps = 4/267 (1%)

Query  17   RAALTEDLGTYGDITTRTVIPAGTRYRARIVAREAGVASGMQLAGIAFRLIDPGLAWRPL  76
            +AAL ED+ +  D +T +++    + +  + A+EAGV +G+ +    F L+D+ ++ +  
Sbjct  18   KAALREDVHS-EDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  77   HP--DGSRFQPGDTLAEIEGEAASILSAERVALNFAGRLSGIATQTAAFVAETAGTKARI  134
            H   DG R+ +GD + EI G   S+L+ ERVALNF  +LSGIA+ TAA+V   ++ + ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  135  TCTRKTTPGLRLVEKQAVLHGGGFNHRFGLSDAILVKDNHIAAAGGIRPVLQAIKARASH  194
              TRKTTP LRL EK AV  GGG+NHRF LSDAI++KDNHIAA G+++  +   +A A+ 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  195  MMRVEIEVDRLDQLAEVLEEGGADVVLLDNMQTAELREAVAMTAGRVVLEASGNMRLARV  254
            +  VE+EV+ L   AE    +G D+++LDNM   ++ +A+++ AGR  +E SGN+ ++ +
Sbjct  197  VKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  255  AEVAATGVDYISVGALTHSARTLDLGL  281
            +   + ++DY+S G+LTHSA++LD+++
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

330) nadC in NC_020516


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (588),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 110/273 (41%), Positives = 189/273 (70%), Gaps = 3/273 (1%)

Query  9    IEIQRNVASSLAEDVGTGDLTAR-LIPAETDARGRVITREEAVICGTAWFDATFAALSPS  67
            ++I+  + ++L EDV + D ++  ++  + +A+  ++++E +V+ G + F+  F+ + + 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  68   ATI--IWHVRDGERVSAGQVLCDVVATARILLTAERTALNFLQLLSGTATATRRFVDAVA  125
             T+    + +DG+R+++G+++ +++++ R LLT ER ALNFLQ LSG A+ T  +V+A++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  126  GTGAKIVDTRKTLPGLRLAQKYAVAVGGGTNHRIGLYDGILIKENHIIAAGSIAKVMEQA  185
            +   K+ DTRKT P LRL +KYAV VGGG NHR+ L D+I++K+NHI A GS+ K + QA
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  186  RAIAPSNVFIevevetldeleealaaGAKMILLDNMSLEQMRKAVEMTAGRAELEASGGV  245
            RA AP    +EVEVE+L   EEA AAG  +I+LDNMSLEQ+ +A+ + AGR+ +E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  246  NLEKVRAIAETGVNRISIGSLTKDVRALDLSLR  278
            ++  +  +   +++ +S GSLT   ++LD+S++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

331) nadC in NC_017067


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (588),  Expect = 1e-40, Method: Compositional matrix adjust.
 Identities = 114/281 (41%), Positives = 186/281 (67%), Gaps = 4/281 (1%)

Query  1    MISAELLRQARIESVAQSLREDIGDGDITAQ-LIPAEKLATARVITREDARLAGSAWVEE  59
            +IS++L      +++  +LRED+   D +++ ++  +  A   ++++E + LAG +  + 
Sbjct  3    IISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  60   VFHQVDPSVTLQ--WQFHDGDDVPANAVIFRMQGPARSLLTAERAALNWLQTLSGVATAC  117
            VF   D+ VT+Q   QF DGD + +  +++ + G+ RSLLT ER ALN LQ LSG+A+  
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  118  AHYARRVSHTNVRLLDTRKTLPGLRLAQKYAVTCGDCDNHRLGLWDAFLIKENHIAACGS  177
            A Y   +++  ++++DTRKT P LRL +KYAV  G+  NHR+ L DA+++K+NHIAA GS
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  178  IANAVAEAHRIAP-GKPVEVETESLAELDQALEAGADIIMLDEFSLADMAEAVKRNAGKA  236
            + +A+A+A+  AP  K VEVE ESLA  ++A  AG DIIMLD+ SL ++ +A+   AG++
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  237  RLEASGGINARTLVPVAETGVDYISIGALTKDVRAIDLSMR  277
            R+E SG I+  T+      ++DY+S G+LT   +++D+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

332) Meso_2555 in NC_008254


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (587),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 119/272 (44%), Positives = 184/272 (68%), Gaps = 6/272 (2%)

Query  15   VRSTLLEDLGRAGDLTTDAVVPAGLHAELTLTARQPgvvagldvaalaFRLIDPAISVKI  74
            ++++L ED+ ++ D +T+A+     +A ++L A+++GV+AGL V    F L+D+ ++ + 
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  75   ERP--DGSAIAPGDVIASVSGPARGLLIAERTALNFLCHLCGIATATAGIVEVVRGHKAQ  132
             +   DG  +++GD++  + G+ R+LL  ER ALNFL HL GIA+ TA+ VE + +++ +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  133  IVCTRKTTPGLRALEKYAVRAGGGSNHRFGLDDAILIKDNHIAIAGGIRPAIERARAHAG  192
            +  TRKTTP LR +EKYAVR GGG NHRF L DAI++KDNHIA  G+++ AI +ARA A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  193  HMVKIEVEVDTLAQLEEVLARKVDAVLLDNMSPEQLARAVELTAGRAITEASGRVTRETA  252
             +  +EVEV++LA  EE  A  VD ++LDNMS EQ+ +A+ L AGR+  E SG +   T 
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  253  PAIAASGVDLISVGWITHSAPVLDI---GLDY  281
            + + + ++D +S G +THSA  LD+   GL Y
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTY  287

333) Cal7507_6007 in NC_019682


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (587),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 116/270 (43%), Positives = 181/270 (68%), Gaps = 6/270 (2%)

Query  18   RGWLVEDIGRGDRTTNSLLSEDAKPGTAKWIAKAPGIIAGLPVAARVFQLLNEKVSFVAV  77
            ++ L ED+   D +TN+++ +++++     +AK +G++AGL V  RVF L++  V+F   
Sbjct  18   KAALREDVHSEDYSTNAIFDHHGQA-KVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  78   AA--EGAKCEPGQVIAEIHGSLDALLMGERVALNLAMRLSGIATLTNIYVEKIADLPARL  135
                +G +  +G+++ EI GS+ +LL  ERVALN+  +LSGIA++T  YVE ++D   ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  136  VDTRKTTPGLRLLEKYATALGGAINHRMGLDDAVMIKDNHiaaaggigeaiTRIRSQIPY  195
             DTRKTTP LRL+EKYA  +GG+ NHR  L DA+M+KDNHIAA G++  AI++ R+  P+
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  196  PLTIEVETESLGQVQEALQYKADIIMLDNMPVEMMRQAVELIRQQDSRVKIEASGNVTLE  255
               +EVE ESL+  +EA     DIIMLDNM++E + QA+ LI    +R +IE SGN+ + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMT  253

Query  256  TIRAVAETGVDYISSSAPITQSKWLDLSMR  285
            TI      ++DY+SS++    +K LD+SM+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

334) Calla_0602 in NC_015949


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (587),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 111/270 (42%), Positives = 183/270 (68%), Gaps = 2/270 (0%)

Query  7    IDKIIKDALVEDMPYGDVTTQLLIPQESISSAVFLSKENGILCGIDVAKRVFEILDSNIK  66
            ID  +K AL ED+   D +T+ ++ +++ +   +++KE G+L G+ V +RVF ++D+++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   FEKLK--TDGDYIQKGDVLAKMQGNTRAILMGERLALNLLQRMSGIATFTNMLAQKIKGY  124
            F++     DGD +  GD++  + G+ R++L  ER+ALN+LQ++SGIA+ T    + + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  125  KATVTDTRKTIPLLRMLDKYAVFVGGGKNHRYSLSDAVLIKDNHIKVIGSITEAVKRAKE  184
            +  V DTRKT P LR+++KYAV VGGG NHR++LSDA+++KDNHI  +GS+  A+ +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  185  NVPHTMKVEVEVRNMQEFEEALLSGADIIMLDHFTVDEMKKAVEKAEGRVLIEASGNINI  244
              P    VEVEV ++   EEA  +G DIIMLD+ +++++ +A+    GR  IE SGNI++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  245  DNIEEIAKTGVDIISVGSITHSVKSLDISL  274
              I  +   ++D +S GS+THS KSLD+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

335) Daci_1541 in NC_010002


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (588),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 114/276 (42%), Positives = 184/276 (67%), Gaps = 3/276 (1%)

Query  18   LPDLMLEPLVRSALLEDLGRAGDLTTDAIVPADAQAELRLVARQEGVLAGLDMARLAFRA  77
            L  + ++  +++AL ED+ ++ D +T+AI   ++QA + L A++ GVLAGL + +  F  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  78   LDAQSRFEPV--LRDGSELAPGQEIARIHGSARAILTAERVALNYLCHLSGVatatasia  135
            +DA+  F+    ++DG  L++G+ +  I GS R++LT ERVALN+L HLSG+A+ TA+  
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  136  raiaDTGARVTCTRKTMPGLRALQKYAVRVGGGSNHRFGLDDAVLIKDNHIALAGGVAEA  195
             A++D   +V  TRKT P LR ++KYAVRVGGG NHRF L DA+++KDNHIA  G+V  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  196  LARARAGVGHMVQIQLEVDTLEQLEVALSLGVEVVLLDNMDLDTLRTAVSMARGRAVTEA  255
            +A+ARA    +  +++EV++L   E A + GV++++LDNM L+ +  A+++  GR+  E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  256  SGRITPETARAVAETGVDQIAVGWITHSARVLDIGL  291
            SG I   T       ++D ++ G +THSA+ LD+++
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

336) Fluta_0712 in NC_015321


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (587),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 113/275 (42%), Positives = 179/275 (66%), Gaps = 6/275 (2%)

Query  3    DEIVKNALQEDLGDGDHSSLACIPQNASGIAKLLVKDTGVLAGVEVAKKVCELVDSTLVF  62
            D+ +K AL+ED+   D S+ A + +++ +   L+ K++GVLAG+ V ++V  L D+ + F
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  63   EE--LLSDGAWVKPGDIAFYLKGSAQSILGAERTLLNFMQRMSGIATQTKTYVDLLEGTN  120
            ++   + DG ++ +GD+ + + GS +S+L  ER  LNF+Q++SGIA+ T +YV+ L +  
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  121  TRLLDTRKTTPGIRYMEKWAVRIGGGMNHRFALYDMIMLKDNHVDFAGGIREAITRTHDY  180
             +++DTRKTTP +R  EK AVR+GGG NHRF L D IMLKDNH+   G+++ AI++++ Y
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  181  LKATGKSLKVEIEVRNIAELHQVLEVGMVDRIMLDNFTPPLLKEAIEIIDGRYETEASGG  240
                     VE+EV ++A  ++    G VD IMLDN +   + +AI +I GR   E SG 
Sbjct  194  APFVK---MVEVEVESLAAAEEAAAAG-VDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  241  ITKQTIRSFAETGVDFISVGALTHSFQSLDMSLKA  275
            I   TI  F   ++D++S G+LTHS +SLD S+K+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

337) lin2132 in NC_003212


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  159 bits (587),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 113/279 (41%), Positives = 191/279 (69%), Gaps = 4/279 (1%)

Query  1    MNSILMNQAIQAFLLEDIGQHDLSSDSIFSSETMGEGVFIAKETGILCGIAIPPKVYEIL  60
            + ++ ++++++A L ED+  +D S+++IF  +  +   ++AKE+G+L G+++  +V+ ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   GGNVQFEAVkk--dgdtikkgdiiATVSAPVRTLLSGERVILNLMQRMSGIATQTHIAVK  118
            +++V F+   +  DGD +  GD++  + ++VR+LL+ ERV LN++Q++SGIA+ T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  QLDDSTIRICDTRKTAPGLRAFDKYAVQSGGGFNHRNGLYDGVMLKDNHIAFSGGITEAV  178
             L+D  I++ DTRKT+P LR F+KYAV+ GGG+NHR  L D++MLKDNHIA  G++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  STVREKLGHMVKIEVETETAPQVKEAVQAGADIIMFDNRTPEEIKQLVTLVPNHITTEIS  238
            +  R     +  +EVE E+ +   EA  AG DIIM+DN + E+I Q +TL++ +   E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNITLDNINHYRGCGANYISLGSLTHSVSALDISFNSKG  277
            GNI +  I+++RG + +Y+S GSLTHS  +LD  F+ KG
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD--FSMKG  284

338) Thicy_0694 in NC_015581


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (585),  Expect = 2e-40, Method: Compositional matrix adjust.
 Identities = 116/272 (43%), Positives = 193/272 (71%), Gaps = 7/272 (2%)

Query  12   NNVRQALTEDLRQGDLTAN-LIAADAQLHAKVICRESAVLCGQAWFNEVFHQLDPEISIH  70
            + ++ AL ED++  D ++N ++  ++Q    ++ +E++VL G + F+ VF  +D+E++++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  71   --WLAKDSDRLAPNQTLCEVRGNARALLTGERTALNFLQTLSATATITAQYVAAMGSMGN  128
                 KD+DRL++ + + E+ G+ R+LLT ER ALNFLQ LS+ A++TA YV A+G   +
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG---D  131

Query  129  TKTQLLDTRKTLPGLRLAQKYAVFCGGGCNHRQGLYDAILIKENHIHACGGISAAIKQAQ  188
             + +++DTRKT P LRL +KYAV  GGG NHR  L DAI++K+NHI A G++  AI QA+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  TQQPGIS-IEVETESLAEVAEALTAGADIIMLDNFSREDIQAAVTLNQGQAKLEVSGNVe  247
            +  P +  +EVE ESLA   EA +AG DIIMLDN S E+I+ A+TL  G++++E SGN++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  laqlaelaqlGVDYISTGAITKHIQAIDLSMR  279
            ++ ++ +  L++DY+S+G++T   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

339) Daud_0123 in NC_010424


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (583),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 122/275 (45%), Positives = 188/275 (69%), Gaps = 2/275 (0%)

Query  1    MNEFELDRLIRTALTEDIgagdwttaatvaagtpaagVLRSREAGVVAGLEVARRVFAVL  60
            +  F++D  +++AL ED+ + D +T A       A   L ++EAGV+AGL V +RVF+++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DPRIQFQN--RVTDGNQVERGTVLAEVSGAARPILTGERVALNFLCHLSGIATRTRRLKE  118
            D+ + FQN  +  DG+++  G ++ E+ G+ R++LT ERVALNFL HLSGIA+ T    E
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  LVAGYPVRLVDTRKTTPGLRMLEKYAVRVGGGHNHRFALDDGVLIKDNHiavaggitaav  178
             +++  +++ DTRKTTP LR++EKYAVRVGGG NHRF L D++++KDNHIA  G++  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  raaraaVHHLLKIEVEVEDLDGVREALAAGADVILLDNMPPPLIKEAVRLVGGRAVLEAS  238
              ARA    +  +EVEVE L +  EA AAG D+I+LDNM+   I +A+ L++GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GNVDEQNIREIAATGVNLISLGRLTHSVPYLDIGL  273
            GN+D   I  + + +++ +S G LTHS   LD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

340) Nham_2821 in NC_007964


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (585),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 119/279 (43%), Positives = 189/279 (68%), Gaps = 5/279 (1%)

Query  4    PALPRVMIEPLVRMALLEDIGRAGDLTTDAIVPAGHRATVLLVARQQGIVAGLDLARLAF  63
              L    I+  ++ AL ED+ ++ D +T+AI     +A V L A++ G++AGL + +  F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   QLIDPAIEMQVAHD--DGAVVEPGDVIATLSGPVRGILTAERVALNFLCRLSGIatatas  121
             L+D+ +  Q +H+  DG  + +GD++  + G+VR++LT ERVALNFL +LSGIA+ TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  122  vvaavRDYKAKIVCTRKTTPGLRAIEKYAVRVGGGSNHRFGLDDAVLIKDNHVAIAGGVT  181
             V A+ D + K+  TRKTTP LR +EKYAVRVGGG NHRF L DA+++KDNH+A  G+V 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  EALQRAKRGVGHLVK-IELEVDTLDQLHEALDQGIDAVLLDNMSPDMLREAVAMVAGRAV  240
             A+ +A R+ + +VK +E+EV++L   +EA   G+D ++LDNMS + + +A++++AGR+ 
Sbjct  185  KAIAQA-RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  241  TEASGRITPATAPSVAATGVDLISIGWLTHSVGILDIGL  279
             E SG I  +T +   + ++D +S G LTHS   LD+++
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

341) Sta7437_4275 in NC_019748


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (584),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 117/277 (43%), Positives = 175/277 (64%), Gaps = 10/277 (3%)

Query  11   LEPLLRQWLLEDIGRGDRTSAGLFSGEVKQGKAEWIVKEEGVIAGLPIAARVFQLLDENV  70
            ++  L+  L ED+   D ++ ++F  +  Q+K   + KE GV+AGL +  RVF L+D +V
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHH-GQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   NFD--PIIAEGEFCSL--GTIIAKIDGNQEALLTGERVALNLAMRLSGIATLTRKYTEQI  126
             F+    + +G+   L  G ++  I G+  +LLT ERVALN+  +LSGIA++T  Y E +
Sbjct  72   TFQNPHQFKDGD--RLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  127  ADLPTKLVDTRKTTPGLRILEKYATQVGGAVNHRLGLDDAVMIKDNHIQaaggiasaial  186
            +D   K+ DTRKTTP LR++EKYA +VGG+ NHR+ L DA+M+KDNHI A G++  AIA 
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  187  lRENIPYPLTIEVETSNLEEVQAALEHGADIIMLDNMSLEMMTQAVQLIRNQNSQIKIEA  246
             R   P+   +EVE  +L   + A   G DIIMLDNMSLE + QA+ LI  ++   +IE 
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIEC  246

Query  247  SGNITLARIRAVAETGVDYISSSAPITRSSWLDLSMR  283
            SGNI ++ I      ++DY+SS++    +  LD+SM+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

342) nadC in NC_010546


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (583),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 111/266 (42%), Positives = 176/266 (67%), Gaps = 6/266 (2%)

Query  16   LQEDLGRGDRTTDG-LELQKMGSGQWVAKAEGIMAGLPIAQRVFQLLNPKIEFIPVVE--  72
            L+ED+   D +T++ ++ +  +     AK  G++AGL + QRVF L+++ + F    +  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  73   EGQRVKTGQVVATFNGSLSALLTGERVALNLAMRLSGIATMTRQYTEIIADLPTQLVDTR  132
            +G+R+ +G++V  + GS+ +LLT ERVALN+  +LSGIA+MT  Y E ++D   ++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  133  KTTPGLRILEKYGIRVGGAKNHRMALDDGVMIKDNHIKAAGSIQEAIQRIRPTIPYPlti  192
            KTTP LR++EKY++RVGG+ NHR  L D++M+KDNHI A GS+Q AI + R+  P+   +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  193  evetttleevKEALMYGADIIMLDNMNLDLMKEAVSYIRGENKQIKIEASGNITLDNIRQ  252
            EVE  +L    EA   G DIIMLDNM+L+ + +A++ I G +   +IE SGNI +  I +
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGNIDMTTISR  257

Query  253  VALTGVDYISSSAPITRSTWLDLSMR  278
                ++DY+SS++    +  LD+SM+
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFSMK  283

343) Thethe_00540 in NC_019970


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (584),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 108/261 (42%), Positives = 174/261 (67%), Gaps = 2/261 (0%)

Query  15   LLEDLTWGDITTDMLVPKGTKSKGYVYAKNDGIIAGIDVFLMVFNTIDSYIEYKK--YFT  72
            L ED+   D +T+ +     ++K  ++AK+ G++AG+ VF  VF  +D+ + +++   F 
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  73   DGEAVKKGDLILETYGDLNSCLKAERVALNLIQRMSGIATYVRKLSDMIKGTNARLTDTR  132
            DG+ +  GDL+LE  G + S L  ERVALN++Q++SGIA+      + + +   ++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  133  KTMPGLRYFDKYAVSVGGGVNHRYNLSDGILIKDNHIKAVGGIKNALTKIKGEVSHTKKV  192
            KT P LR F+KYAV VGGG NHR+NLSD+I++KDNHI AVG++++A+++ ++  +  K V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  193  EIEVETIHELKEALKYGADIIMLDNMTIDMMKEAVEITNGRAILEASGNITEKNILDVAK  252
            E+EVE++    EA   G DIIMLDNM+++ + +A+ +  GR+ +E SGNI    I     
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  253  TGVDIISIGAITHSVKALDIS  273
             ++D +S G++THS K+LD+S
Sbjct  261  LAIDYVSSGSLTHSAKSLDFS  281

344) Maqu_0952 in NC_008740


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (583),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 113/281 (41%), Positives = 185/281 (66%), Gaps = 4/281 (1%)

Query  1    MISAELLRQARIESVAQSLREDIGDGDITAQ-LIPAEKLATARVITREDARLAGSAWVEE  59
            +IS++L      +++  +LRED+   D +++ ++  +  A   ++++E + LAG +  + 
Sbjct  3    IISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  60   VFRQVDPSVRLQ--WQFHDGDDVPANAVIFRMQGPARSLLTAERAALNWLQTLSGVATAC  117
            VF   D+ V +Q   QF DGD + +  +++ + G+ RSLLT ER ALN LQ LSG+A+  
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  118  AHYARRVSHTNVRLLDTRKTLPGLRLAQKYAVTCGDCDNHRLGLWDAFLIKENHIAACGS  177
            A Y   +++  ++++DTRKT P LRL +KYAV  G+  NHR+ L DA+++K+NHIAA GS
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  178  IANAVAEAHRIAP-GKPVEVETESLAELDQALEAGADIIMLDEFSLADMAEAVKRNAGKA  236
            + +A+A+A+  AP  K VEVE ESLA  ++A  AG DIIMLD+ SL ++ +A+   AG++
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  237  RLEASGGINARTLVPVAETGVDYISIGALTKDVRAIDLSMR  277
            R+E SG I+  T+      ++DY+S G+LT   +++D+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

345) AciPR4_4253 in NC_014963


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (583),  Expect = 4e-40, Method: Compositional matrix adjust.
 Identities = 114/275 (42%), Positives = 178/275 (65%), Gaps = 7/275 (2%)

Query  10   IERVVKMALLEDAPWGDLTSQTLIPASARMTADLVAREAGVFCGGEIF--AAAMtltdpt  67
            I+  +K AL ED    D ++++++   ++    L A+EAGV+ G  +F    ++  ++ T
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   tktdllVEDGEAFAIGDVLATATGPAHGVLQAERVALNFVQRLSGISTMTSRYVAEIAGT  127
             +      DG+ ++ GD++    G+ +++L  ERVALNF+Q+LSGI++MT+ YV  +++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  128  HARVVDTRKTTPGLRLFERYAVRCGGGHNHRFSLSDAVMAKDNHLAVLTDDGRRDLTEAL  187
            + +V DTRKTTP LRLFE+YAVR GGG NHRF+LSDA+M KDNH+A +    +     A+
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK-----AI  187

Query  188  RAARASLPHTAHFEVEVDRPDQIEAVLAAGVDTIMLDNFTLEQMREGVRQIAGRALVEAS  247
              ARA  P     EVEV+     E   AAGVD IMLDN +LEQ+ +++  IAGR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  248  GTVRLETIGAIAHTGVDIISVGALTHSVRSLDLGL  282
            G + + TI+ +   ++D +S G+LTHS +SLD+++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

346) DelCs14_4992 in NC_015563


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (582),  Expect = 4e-40, Method: Compositional matrix adjust.
 Identities = 113/276 (41%), Positives = 184/276 (67%), Gaps = 3/276 (1%)

Query  18   LPDLMLEPLVRSALLEDLGRAGDLTTDAIVPADAQAELRLVARQEGVLAGLDMARLAFRA  77
            L  + ++  +++AL ED+ ++ D +T+AI   ++QA + L A++ GVLAGL + +  F  
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  78   LDAQSRFEPV--LRDGSELAPAQEIARIHGSARAILTAERVALNYLCHLSGVatatasia  135
            +DA+  F+    ++DG  L++++ +  I GS R++LT ERVALN+L HLSG+A+ TA+  
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  136  raiaDTGARVTCTRKTMPGLRALQKYAVRVGGGSNHRFGLDDAVLIKDNHIALAGGVAEA  195
             A++D   +V  TRKT P LR ++KYAVRVGGG NHRF L DA+++KDNHIA  G+V  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  196  LARARAGVGHMVQIQLEVDTLEQLEVALSLGVEVVLLDNMDLDTLRTAVSMARGRAVTEA  255
            +A+ARA    +  +++EV++L   E A + GV++++LDNM L+ +  A+++  GR+  E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  256  SGRITPETARAVAETGVDQIAVGWITHSARVLDIGL  291
            SG I   T       ++D ++ G +THSA+ LD+++
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

347) AMBAS45_14570 in NC_018679


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (582),  Expect = 5e-40, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 193/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELNAANDITANLIDESVNAKATIITREPCVVCGIAWANQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK +++++E+ V+ G++  ++ F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDKVDANTVLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLDG  129
            ++    + KDGD++ +  +++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  SNTKILDTRKTLPGLRHAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAVSRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KA+++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  TMMP-GKPveveveNLTELEQALSAGADIVMLDNFSNEQIQQAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE+L+  E+A +AG DI+MLDN S EQI+QA++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

348) MYSTI_04945 in NC_020126


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  158 bits (582),  Expect = 5e-40, Method: Compositional matrix adjust.
 Identities = 103/257 (41%), Positives = 176/257 (69%), Gaps = 3/257 (1%)

Query  21   AGDVTSQALIPPDAEGSAELVAKEQLVLAGLDAFIRVFHKVDPDVEVELLRQ--DGQEVK  78
            + D +++A++  ++++   L AKE  VLAGL  F RVF   D++V  +  +Q  DG+ + 
Sbjct  27   SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLT  86

Query  79   PKVVAARCHGRLRSLLAAERTALNLVQRAAGIATLAQQAMTSVRGSKMQVLDTRKTPPGM  138
            +  +     G +RSLL+ ER ALN++Q+ +GIA+++   + ++ + +++V+DTRKT P +
Sbjct  87   SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNL  146

Query  139  RVLAKDAVRMGGATNHRFGLFDGVLIKDNHIAAVGGSISEALRRAKANGPRLCKIEIEVT  198
            R++ K AVR+GG+ NHRF L D++++KDNHIAAV GS+  A+ +A+A +P +  +E+EV 
Sbjct  147  RLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV-GSVQKAIAQARAYAPFVKMVEVEVE  205

Query  199  NLKQLAEALECGADVVMLDNMDDAQIREAVKLAAGRVPLEVSGGVTLDRLPRLAKMGVDF  258
            +L    EA   G D++MLDNM   QI +A+ L AGR  +E SG + +  ++R+  +++D+
Sbjct  206  SLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDY  265

Query  259  VSMGALTHSARAMDLSL  275
            VS G+LTHSA+++D+S+
Sbjct  266  VSSGSLTHSAKSLDFSM  282

349) nadC in NC_003063


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (581),  Expect = 5e-40, Method: Compositional matrix adjust.
 Identities = 117/282 (42%), Positives = 182/282 (65%), Gaps = 5/282 (1%)

Query  1    MILSPLPRLIIEPPVRNALLEDLGLAGDITSTAVIPADHRSVVVMAAREQGVIAGLDAAE  60
            +I + L  + I+  ++ AL ED+  + D ++ A++  + ++ V + A+E GV+AGL   +
Sbjct  3    IISTDLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  61   LAFQLVDPAIRMNRHiadgaavaagdiiaTIE--GPSRGLLTGERTALNFLGHLSGIASV  118
              F L D+ +  +       +         +E  G+ R+LLT ER ALNFL HLSGIAS+
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  119  TAKIVAAIAGTKASVACTRKTTPGLRALEKYAVRAGGGMNHRFALYDAVLIKDNHIAVAG  178
            TA  V A+++ +  V  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHIA  G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  179  GVREAIRRARHGVGHLVK-IEVEVDTLVQLHEAMEEGVDAVLLDNMTPEQLREAVEIVAG  237
            +V+ AI +AR + + +VK +EVEV++L   +EA   GVD ++LDNM+ EQ+ +A+ ++AG
Sbjct  182  SVQKAIAQAR-AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  238  RAITEASGRINPQTAAAIAATGVDLISIGWITHSAPVLDIGL  279
            R+  E SG I+  T + + + ++D +S G +THSA  LD+++
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

350) Marky_2090 in NC_015387


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (580),  Expect = 6e-40, Method: Compositional matrix adjust.
 Identities = 130/273 (48%), Positives = 194/273 (72%), Gaps = 4/273 (1%)

Query  1    MNLREQIRTWLLEDVGHGDLTTQLTVPQDAQGQGVILAKEAGVLAGIEAARLVFHEVDPT  60
             ++ + +++ L EDV   D +T+    +++Q++  ++AKEAGVLAG+   + VF   D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  61   LRFTA---LKADGDRLEPVQAVARIEGRLASILTAERLALNLLQRLSGIATLTRKYVEAV  117
            + F     +K DGDRL + + V  I G + S+LT ER+ALN+LQ+LSGIA++T  YVEA+
Sbjct  71   VTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  118  AGTQARILDTRKTTPGLRALEKYAVRVGGGHNHRFGLFDGILIKDNHIaaaggvraavtr  177
            ++ + +++DTRKTTP LR +EKYAVRVGGG NHRF L D+I++KDNHIAA G+V+ A+++
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  178  araraPHGLRvevevttlaeleealeaGADVILLDNMDLPTLRQAVARTAGRARLEASGG  237
            ARA AP    VEVEV +LA  EEA  AG D+I+LDNM L  + QA++  AGR+R+E SG 
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  238  MTLERVRAVAETGVDFISVGALTHSAKALDLSL  270
            + +  +      ++D++S G+LTHSAK+LD+S+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

351) MASE_14050 in NC_018632


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (580),  Expect = 6e-40, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 193/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELNAANDITANLIDESVNAKATIITREPCVVCGIAWANQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK +++++E+ V+ G++  ++ F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDKVDANTVLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLDG  129
            ++    + KDGD++ +  +++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  SNTKILDTRKTLPGLRHAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAVSRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KA+++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  TMMP-GKPveveveNLTELEQALGAGADIVMLDNFSNEQIQQAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE+L+  E+A +AG DI+MLDN S EQI+QA++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

352) nadC in NC_017549


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (580),  Expect = 6e-40, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 190/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TTVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGihraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  ESTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
             +T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

353) ES1_08710 in NC_021043


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (579),  Expect = 7e-40, Method: Compositional matrix adjust.
 Identities = 120/276 (44%), Positives = 184/276 (67%), Gaps = 2/276 (0%)

Query  3    LLQFYVDDLIKRAITEDINYIDSTTDLLIDEDDISEAYFVSKADGVLAGIDVAMRVFTLL  62
            L  F +DD +K A+ ED++  D +T+ ++D+++ +   + +K  GVLAG+ V  RVFTL+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DD--TIEMNIHFKDGDAIKKGDVIAEFKGHTCAMLKAERTALNLLQHMSGIASYTNKCVK  120
            D   T++   +FKDGD +  GD++ E+ G   ++L  ER ALN+LQH+SGIAS T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  121  AVEGTDASIADTRKTLPGLRPLQKYSVVAGGGRNHRYNLTDAAMLKDNHIDAYGGITQAV  180
            A+ +    + DTRKT P LR ++KY+V  GGG NHR+NL+DA MLKDNHI A G++ +A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  181  TALRKKAGHMLQIEVEVRNFDELNEALAVKADVIMLDNMSCEDMKKAVKITAGRAKLEAS  240
            +  R  A  +  +EVEV ++   +EA A   D+IMLDNMS E++ +A+ + AGR+++E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  241  GNVTLDNIRDVALTGVDIISLGALTHSVTAFDISMK  276
            GN+ +  I      ++D +S G+LTHS  ++D+SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

354) PADK2_23550 in NC_018080


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (579),  Expect = 7e-40, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 190/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGidraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  ESTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
             +T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

355) CC_2915 in NC_002696


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (578),  Expect = 8e-40, Method: Compositional matrix adjust.
 Identities = 109/266 (41%), Positives = 177/266 (67%), Gaps = 3/266 (1%)

Query  18   ALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCARLALAAMDPTARFEIVTP  77
            AL ED+ ++ D + +A +D +++  V++ +++ G ++GLT  +  ++  D+   F+    
Sbjct  20   ALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  78   --DGADVTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTRAYVRLVEGTSATIVD  135
              DG  +T+G ++    G+ R++L  ER +LN+L ++SGIA++T AYV  + +    + D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  136  TRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGGVGEAVRRARAHAGHLV  195
            TRKTTP LR +EKYAVR GGG NHRF L DAI++KDNH+AA G+V  A+ +ARA A  + 
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  196  KVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAVLEASGGVNLTTVRAI  255
             VEVEV++L   EEA   G D++MLDN SL ++  A++L  GR+ +E SG +++TT+  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  256  AETGVDVISVGALTHSAPVLDIGLDA  281
               ++D +S G+LTHSA  LD+++ +
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMKG  284

356) CCNA_03009 in NC_011916


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (578),  Expect = 8e-40, Method: Compositional matrix adjust.
 Identities = 109/266 (41%), Positives = 177/266 (67%), Gaps = 3/266 (1%)

Query  18   ALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCARLALAAMDPTARFEIVTP  77
            AL ED+ ++ D + +A +D +++  V++ +++ G ++GLT  +  ++  D+   F+    
Sbjct  20   ALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ  78

Query  78   --DGADVTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTRAYVRLVEGTSATIVD  135
              DG  +T+G ++    G+ R++L  ER +LN+L ++SGIA++T AYV  + +    + D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  136  TRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGGVGEAVRRARAHAGHLV  195
            TRKTTP LR +EKYAVR GGG NHRF L DAI++KDNH+AA G+V  A+ +ARA A  + 
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  196  KVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAVLEASGGVNLTTVRAI  255
             VEVEV++L   EEA   G D++MLDN SL ++  A++L  GR+ +E SG +++TT+  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  256  AETGVDVISVGALTHSAPVLDIGLDA  281
               ++D +S G+LTHSA  LD+++ +
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMKG  284

357) EUS_21910 in NC_021011


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (578),  Expect = 9e-40, Method: Compositional matrix adjust.
 Identities = 120/276 (44%), Positives = 184/276 (67%), Gaps = 2/276 (0%)

Query  3    LLQFYVDDLIKRAITEDINYIDSTTDLLIDEDDISEAYFVSKADGVLAGIDVAMRVFTLL  62
            L  F +DD +K A+ ED++  D +T+ ++D+++ +   + +K  GVLAG+ V  RVFTL+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DD--TIEMNIHFKDGDAIKKGDVIAEFKGHTCAMLKAERTALNLLQHMSGIASYTNKCVK  120
            D   T++   +FKDGD +  GD++ E+ G   ++L  ER ALN+LQH+SGIAS T   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  121  AVEGTDASIADTRKTLPGLRPLQKYSVVAGGGRNHRYNLTDAAMLKDNHIDAYGGITQAV  180
            A+ +    + DTRKT P LR ++KY+V  GGG NHR+NL+DA MLKDNHI A G++ +A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  181  TALRKKAGHMLQIEVEVRNFDELNEALAVKADVIMLDNMSCEDMKKAVEITAGRAKLEAS  240
            +  R  A  +  +EVEV ++   +EA A   D+IMLDNMS E++ +A+ + AGR+++E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  241  GNVTLDNIRDVALTGVDIISLGALTHSVTAFDISMK  276
            GN+ +  I      ++D +S G+LTHS  ++D+SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

358) Glaag_1005 in NC_015497


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (578),  Expect = 9e-40, Method: Compositional matrix adjust.
 Identities = 113/275 (42%), Positives = 182/275 (67%), Gaps = 7/275 (2%)

Query  6    IQQAVKAALLEDLGGSECIVGDITANLIPEPQHIKVNIITREDCVVAGKEWVNATFQQLD  65
            I++++KAAL ED+ + +      T  ++ +  + KV+++++E  V+AG    +  F  +D
Sbjct  13   IDDTLKAALREDVHSEDYS----TNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  66   KGIKID--WKVEDAQHVKADTVLCEISGNARMILTGERTALNFLQTLSGTATVVADYVKA  123
              + ++   +  D++++ ++ ++ EI G+ R +LT ER ALNFLQ LSG A++ A YV A
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  124  LGDSETKLLDTRKTLPGMRLAQKYAVTCGGGKNHRIGLYDAYLIKENHILACGSIANAIE  183
            LGD   K++DTRKT P +RL +KYAV  GGG NHR+ L DA ++K+NHI A GS+ +AI 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  184  KARQMHPDIP-VEVEVENLDELSQALDANADIIMLDNFTLDDTRQAVVLTKGKSKLEVSG  242
            +AR   P +  VEVEVE+L    +A  A  DIIMLDN +L++  QA+ L  G+S++E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  243  NITKERIAELAQVGVDYISSGALTKHVQAIDLSLR  277
            NI    I+ +  +++DY+SSG+LT   +++D+S++
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

359) nadC in NC_015125


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  157 bits (578),  Expect = 9e-40, Method: Compositional matrix adjust.
 Identities = 115/280 (42%), Positives = 186/280 (67%), Gaps = 6/280 (2%)

Query  2    LTRATIDRVVSAALEEDAPWGDLTSETLIPAGATARAELVARVDgvfsgaavfaaafTLT  61
            LT   ID  + AAL ED    D ++++++   + A+  L A+  GV++G +VF   FTL 
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  62   DPSVVID--QRVGDGERFAPGDTLAVVTGPARAVLTAERIGLNFVQRMSGIATLTNRYVT  119
            D+ V ++  ++  DG+R+++GD +  + G+ R++LT ER++LNF+Q++SGIA++T  YV 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  120  EVAHTGARVVDTRKTTPGLRAIERQAVRDGGGHNHRFSLSDAVMAKDNHLAVLTASGLSV  179
             +++   +V DTRKTTP LR +E+ AVR GGG NHRF+LSDA+M KDNH+A + +   ++
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  180  TQALESAIARLPHTTHVEVEVDRLDQIDAVLAAGVGTIMLDNFSLEDLRIGVARIAGAAQ  239
            +QA   A    P    VEVEV+ L   +   AAGV+ IMLDN SLE++  +++ IAG ++
Sbjct  188  AQARAYA----PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR  243

Query  240  VEASGGVTLETVRAIAETGVDVISVGALTHSAPALDLGLD  279
            +E SG + + T+  +   ++D +S G+LTHSA +LD+++ 
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

360) Thexy_0431 in NC_015555


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (575),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 101/231 (44%), Positives = 158/231 (69%), Gaps = 2/231 (0%)

Query  45   DGIIAGIDVFLMVFNAFDKDI--EHVKYFKDGDAVKKGDLILETYGELNSCLKAERVALN  102
             G++AG+ VF  VF  FD ++  ++   FKDGD +  GDL+LE  G + S L  ERVALN
Sbjct  51   AGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALN  110

Query  103  LMQRMSGIATYVRMLKDIISETKAQLTDTRKTMPGLRYFDKYAVLVGGGINHRYNLSDGI  162
            ++Q++SGIA+      + +++ + ++ DTRKT P LR F+KYAV VGGG NHR+NLSD+I
Sbjct  111  FLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI  170

Query  163  LIKDNHIKAVGGIKNALTMIKNSVSHTKKIEIEVETIHELKEALKYGADIIMLDNMTIGM  222
            ++KDNHI AVG++++A++  +   +  K +E+EVE++    EA   G DIIMLDNM++  
Sbjct  171  MLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQ  230

Query  223  MKEAVEITDGKAILEASGNINEDNILQVAKTGVDIISVGAITHSVKALDIS  273
            + +A+ +  G++ +E SGNI+   I +    ++D +S G++THS K+LD+S
Sbjct  231  IEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

361) GbCGDNIH1_0642 in NC_008343


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (576),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 112/264 (43%), Positives = 175/264 (67%), Gaps = 5/264 (1%)

Query  23   RAGDITTDAVIPATQTARVALQARQPGVIAGLDLARLAFHLVEPRIHFSI--HVPDGGRV  80
            ++ D +T+A++     A+V+L A+++GV+AGL + +  F L ++ + F    +  DG+R+
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRL  85

Query  81   MPGDAIATIDGPARGLLTGERVALNFLGHLSgiatatagiadaiaHTKARICCTRKTTPG  140
             +GD +  I G+ R+LLT ERVALNFL HLSGIA+ TA+  +A+++ + ++  TRKTTP 
Sbjct  86   TSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPN  145

Query  141  LRAVEKYAVRAGGGSNHRFGLDDAVLIKDNHIAIAGGVATAIKRARSSIGHLVKIEVEVD  200
            LR  EKYAVR GGG NHRF L DA+++KDNHIA  G+V  AI +AR+    +  +EVEV+
Sbjct  146  LRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVE  205

Query  201  TLTQLHQVLEYDIDAVLLDNMDPATLRQAVGIINGRAIAEASGRITPQTAPAIAESGVDL  260
            +L+  ++    ++D ++LDNM    + QA+ +I GR+  E SG I   T + +   ++D 
Sbjct  206  SLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDY  265

Query  261  ISAGWLTHSSAVLDI---GLDFLD  281
            +S+G LTHS+  LD+   GL +LD
Sbjct  266  VSSGSLTHSAKSLDFSMKGLTYLD  289

362) AMEC673_14375 in NC_018678


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (577),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 193/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELNAANDITANLIDESVNAKATIITREPCVVCGIAWANQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK +++++E+ V+ G++  ++ F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDKVDANTVLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLDG  129
            ++    + KDGD++ +  +++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  SDTKILDTRKTLPGLRHAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAVSRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KA+++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  TMMP-GKPveveveNLTELEQALGAGADIVMLDNFSNEQIQQAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE+L+  E+A +AG DI+MLDN S EQI+QA++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

363) nadC in NC_012808


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (575),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 105/262 (41%), Positives = 174/262 (67%), Gaps = 7/262 (2%)

Query  28   RAGDITTDAIVPAGERMEAVIASRQDGVIAGTDAAAIAFELIDPSLAVSVERP----DGS  83
            ++ D +T+AI     +    + +++ GV+AG       F L+D+   V+ + P    DG 
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA--EVTFQNPHQFKDGD  83

Query  84   RVAPGDTVIRLSGPARAVLTAERVALNLLCRLSGVATATASLVEAARPHGKARIVCTRKT  143
            R+++GD V+ + G+ R++LT ERVALN+L +LSG+A+ TA+ VEA   +++ ++  TRKT
Sbjct  84   RLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL-GDDRIKVFDTRKT  142

Query  144  TPGLRALEKHAVRAGGGSNHRFGLDDAVLIKDNHVAVAGGIIPAIERARARTGHLVKIEV  203
            TP LR +EK AVR GGG NHRF L DA+++KDNH+A  G++  AI +ARA +  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  204  EVDTLAQLEEALSVGADAVLLDNMSPDTLRQAVAMVDGRAVTEASGRINRETVGAVAASG  263
            EV++LA  EEA + G D ++LDNMS + + QA++++ GR+  E SG I+  T++   + +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  264  VDLISVGWITHSSAIIDLGLDA  285
            +D +S G +THS+  +D+++ +
Sbjct  263  IDYVSSGSLTHSAKSLDFSMKG  284

364) Odosp_0838 in NC_015160


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (575),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 106/264 (41%), Positives = 175/264 (67%), Gaps = 2/264 (0%)

Query  15   AIEEDIATGDVTTNSIIPAHSRAVAEMKMKADGVISGLAIAKRVYEKFEKDILWdakvkd  74
            A+ ED+ + D +TN+I+  H++A   +  K  GV++GL++ +RV+  F+ ++  +   + 
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  75   gdrv--kkgdIILRIEASYRCLLLGERLSLNILQRMSGIATETARYVEELAGTHTQLLDT  132
             D      GD++L I +S R LL  ER++LN+LQ++SGIA+ TA YVE L++ + +++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  133  RKTAPGLRVLDKMAVKDGGAINHRMGLYDMAMIKDNHIKVAGGITNAVNAVRAHIPAGIK  192
            RKT+P LR+++K AV+ GG+ NHR  L D  M+KDNHI   G++ +A+   RA  P    
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  193  IEVETTNLAEVREALATHADIIMLDNMSNAEMAEAVKIIHGQAKTEASGNMSIPRLKEVA  252
            +EVE  +LA   EA A+  DIIMLDNMS  ++ +A+ +I G+++ E SGN+ +  +    
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  253  ATGVDFISVGALTHSVTALDISMN  276
            + ++D++S G+LTHS  +LD+SM+
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

365) G655_23255 in NC_020912


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (576),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 189/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGidraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EGTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
              T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

366) nadC in NC_011770


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (577),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 189/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANIRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGidraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EGTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
              T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

367) nadC in NC_017548


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (576),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 189/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGidraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EGTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
              T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

368) nadC in NC_002516


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (576),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 189/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGidraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EGTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
              T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

369) nadC in NC_008463


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (577),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 189/272 (70%), Gaps = 4/272 (1%)

Query  12   EIQANVRTALAEDVGGGDLTAQ-LIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRV  70
            +I+  +++AL EDV + D +++ ++D + +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   LV--TWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAG  128
                  Q  DG+R+ + ++++++ G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TTVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGihraiaear  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++++AIA+AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGIN  247
              AP  K VEVEVE+L    +A  AG DI+MLD++SL+++  A++L AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EGTLRNIAETGVDYISIGTLTKDVRAVDLSMR  279
              T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

370) Pcryo_0602 in NC_007969


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (576),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 108/267 (41%), Positives = 182/267 (69%), Gaps = 3/267 (1%)

Query  18   VEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMDLARLSFALIDEQIEF-V  76
            + AAL ED+ +  D +++A +  + QA++ + A++AGV+ G+ + +  F+L+D ++ F  
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  77   AQVY-DGEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIATDTKKVVDSVAAYPAQ  135
            ++ + DG+ + +G ++  + G+ R+LLT ER ALNF+ HLSGIA+ T   V++++    +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  136  ITCTRKTIPGLRIVQKYAVRCGGGRNHRLGLDDAILIKDNHIAIAGDIKTAIEQAQEFAG  195
            +  TRKT P LR+ +KYAVR GGG NHR+ L DAI++KDNHIA  G ++ AI QA+ +A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  196  HLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKGRAKTEASGGITPKTV  255
             +  +EVEV++LA  E+A  AGV +++LDNMS E + QA+++  GR++ E SG I   T+
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  256  QAVAETGVDFIAMGYLTHSTTALDIGL  282
                  ++D+++ G LTHS+ +LD+++
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

371) PSYCG_03340 in NC_021661


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (576),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 108/267 (41%), Positives = 182/267 (69%), Gaps = 3/267 (1%)

Query  18   VEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMDLARLSFALIDEQIEF-V  76
            + AAL ED+ +  D +++A +  + QA++ + A++AGV+ G+ + +  F+L+D ++ F  
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  77   AQVY-DGEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIATDTKKVVDSVAAYPAQ  135
            ++ + DG+ + +G ++  + G+ R+LLT ER ALNF+ HLSGIA+ T   V++++    +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  136  ITCTRKTIPGLRIVQKYAVRCGGGRNHRLGLDDAILIKDNHIAIAGDIKTAIEQAQEFAG  195
            +  TRKT P LR+ +KYAVR GGG NHR+ L DAI++KDNHIA  G ++ AI QA+ +A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  196  HLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKGRAKTEASGGITPKTV  255
             +  +EVEV++LA  E+A  AGV +++LDNMS E + QA+++  GR++ E SG I   T+
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  256  QAVAETGVDFIAMGYLTHSTTALDIGL  282
                  ++D+++ G LTHS+ +LD+++
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

372) SYO3AOP1_0647 in NC_010730


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (574),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 116/265 (44%), Positives = 177/265 (67%), Gaps = 8/265 (3%)

Query  15   LEEDVGHQDITTDNL-DTDKSIEAYMIAKEDGILAGIEFAKEVYNLVGG----CKLENFV  69
            L EDV  +D +T+ + D +      ++AKE G+LAG+   + V+ L ++     + ++F 
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF-  79

Query  70   KDGASIKKGDIIAIVYGNGKSILKAERLSLNIIQRLSGIATLTNKYVEKIKDTGVKLLDT  129
            KDG  +  GD++  + G+ +S+L  ER++LN++Q+LSGIA++T  YVE + D  +K++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  130  RKTTPGFRAFEKYAVKVGGGDNHRFALYDMVMIKDNHIALAGSITEAVNQIKKKVSPMVK  189
            RKTTP +R FEKYAV+VGGG NHRF L D +M+KDNHIA  GS+  A+ Q  +  +P VK
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ-ARAYAPFVK  198

Query  190  -IEVEVSSFEQLEEALKNPVDVIMLDNMSATDVKKAVKLINKSKLVEVSGNITIENIRDY  248
             +EVEV S+   EEA    VD+IMLDNMS  ++ +A+ LI     +E SGNI +  I  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  249  ALAGPDFISTGAVSHSAKWLDISLK  273
               + D++S+G+++HSAK LD+S+K
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

373) Mext_2646 in NC_010172


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (574),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 105/262 (41%), Positives = 175/262 (67%), Gaps = 7/262 (2%)

Query  28   RAGDITTDAIVPAGERMEAIIASRQDGVIAGTDAAAIAFELIDPSLTVSIERP----DGS  83
            ++ D +T+AI     +    + +++ GV+AG       F L+D+   V+++ P    DG 
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE--VTFQNPHQFKDGD  83

Query  84   RVAPGDTVIRLSGPARAVLTAERVALNLLCRLSGVATATASLVEVARPHGKARIVCTRKT  143
            R+++GD V+ + G+ R++LT ERVALN+L +LSG+A+ TA+ VE A  +++ ++  TRKT
Sbjct  84   RLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE-ALGDDRIKVFDTRKT  142

Query  144  TPGLRALEKHAVRAGGGSNHRFGLDDAVLIKDNHVAVAGGIIPAIERARARTGHLVKIEV  203
            TP LR +EK AVR GGG NHRF L DA+++KDNH+A  G++  AI +ARA +  +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  204  EVDTLAQLEEALSVGADAVLLDNMSPDTLRQAVAMVDGRAVTEASGRINRETVGAVAASG  263
            EV++LA  EEA + G D ++LDNMS + + QA++++ GR+  E SG I+  T++   + +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  264  VDLISVGWITHSSAIIDLGLDA  285
            +D +S G +THS+  +D+++ +
Sbjct  263  IDYVSSGSLTHSAKSLDFSMKG  284

374) SCATT_26090 in NC_017586


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (574),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 116/283 (41%), Positives = 188/283 (67%), Gaps = 5/283 (1%)

Query  69   IVEAGLDPVQVEDIAHLAIEEDLDHGVDVTTVATIPEEAVSVGDFTAREAGVVAGLHIAE  128
            I+ ++L P Q++D    A+ ED+ H+ D +T A + +++ +   + A+EAGV+AGL + +
Sbjct  3    IISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  129  AVLSVVCTE-EFEVERHVADGDRVEAGQVLLSVRTRTRDLLTAERSALNLLCHLSGIata  187
             V+++  +E  F+  ++  DGDR+ +G+++L +    R LLT ER ALN+L HLSGIA+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  188  trawadalagtGARVRDTRKTTPGLRALQKYAVRCGGGVNHRMSLSDAALVKDNHVVAAG  247
            T A  +AL++   +V DTRKTTP LR ++KYAVR GGG NHR +LSDA ++KDNH+ A G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  248  GVAEAFRKVR--EEFPDLAIEVEVDTLHQVREVLDAGADLILLDNFTPAETAEAVALVAG  305
            +V  A+ + R    F  + +EVEV++L    E   AG D+I+LDN +  +  +A++L+AG
Sbjct  182  SVQKAIAQARAYAPFVKM-VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  306  RAMLESSGRLTLDNARAYAETGIDYLAVGALTHSARVLDIGLD  348
            R+ +E SG + +     +   +IDY++ G+LTHSA+ LD+++ 
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

375) SCAT_2627 in NC_016111


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (574),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 116/283 (41%), Positives = 188/283 (67%), Gaps = 5/283 (1%)

Query  69   IVEAGLDPVQVEDIAHLAIEEDLDHGVDVTTVATIPEEAVSVGDFTAREAGVVAGLHIAE  128
            I+ ++L P Q++D    A+ ED+ H+ D +T A + +++ +   + A+EAGV+AGL + +
Sbjct  3    IISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  129  AVLSVVCTE-EFEVERHVADGDRVEAGQVLLSVRTRTRDLLTAERSALNLLCHLSGIata  187
             V+++  +E  F+  ++  DGDR+ +G+++L +    R LLT ER ALN+L HLSGIA+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  188  trawadalagtGARVRDTRKTTPGLRALQKYAVRCGGGVNHRMSLSDAALVKDNHVVAAG  247
            T A  +AL++   +V DTRKTTP LR ++KYAVR GGG NHR +LSDA ++KDNH+ A G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  248  GVAEAFRKVR--EEFPDLAIEVEVDTLHQVREVLDAGADLILLDNFTPAETAEAVALVAG  305
            +V  A+ + R    F  + +EVEV++L    E   AG D+I+LDN +  +  +A++L+AG
Sbjct  182  SVQKAIAQARAYAPFVKM-VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  306  RAMLESSGRLTLDNARAYAETGIDYLAVGALTHSARVLDIGLD  348
            R+ +E SG + +     +   +IDY++ G+LTHSA+ LD+++ 
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

376) Swol_0107 in NC_008346


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  156 bits (577),  Expect = 9e-40, Method: Compositional matrix adjust.
 Identities = 120/279 (44%), Positives = 185/279 (67%), Gaps = 4/279 (1%)

Query  1    MNDWMVKEIIKRALEEDLGNGDITTRNLIAETQEGQGLFLAKASGIVAGLEVSATVFSCL  60
            +    + + +K AL ED+ + D +T  ++ +  +++  ++AK +G++AGL V   VF+ +
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   EPAVQFTA---FIHDGDEIKPGDRIARVEGKMSTLLSGERVALNFLQRLSGIASKTRNMA  117
            ++ V F     F  DGD + +GD +  + G + +LL+ ERVALNFLQ+LSGIAS T    
Sbjct  68   DAEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  118  ESIKYQHAVLVDTRKTTPGLRLLEKYAVRVGGAKNHRFGLYDGVMIKDNHIQAVGGIQKA  177
            E++  ++  + DTRKTTP LRL+EKYAVRVGG+ NHRF L D++M+KDNHI AVG++QKA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  178  VSTLRQKVPHTLKIevevenlqqlqealeaRADIILLDNMDSESMRKAVEIVNGQALLEA  237
            ++  R   P    +EVEVE+L   +EA  A  DII+LDNM  E + +A+ ++ G++ +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  238  SGGVNEENIVEIAKTGVDFISCGALTHSAPSLDISFKIL  276
            SG ++   I  +   ++D++S G+LTHSA SLD+S K L
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

377) nadC in NC_002570


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (573),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 113/260 (44%), Positives = 183/260 (71%), Gaps = 2/260 (0%)

Query  16   EDGFNGDITTTAIFPPSEKCVAHVKAKARGIVSGLSLLEIGYSLLDDHIHVEE--RVKDG  73
            ED  + D +T AIF    +    + AK  G+++GL++++  ++L+D ++  ++  + KDG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  74   QEVRPGDVIATIQGPVHHVLFGERVLLNLIQRMSGIATVTRKAIDTLNDPSIRICDTRKT  133
            + + +GD++  I G+V+ +L  ERV LN++Q++SGIA++T   +++L D  I++ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  134  TPGLKLFEKYAVRSGGGYNHRLNLSDMVLIKDNHIAQAKGIRQAVTQARSVIGHSLKIev  193
            TP L+LFEKYAVR GGGYNHR+NLSD +++KDNHIA   ++++A++QAR+       +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  194  evenreqleeavDAGVDIIMFDNMPPHIIKEYVALVPDGIVTEASGGISLQTIASYRGCG  253
            EVE+    EEA  AGVDIIM+DNM+ + I + ++L+++    E SG I + TI+ +RG +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  254  VDYLSLGFITHSAPILDFTL  273
            +DY+S G +THSA  LDF++
Sbjct  263  IDYVSSGSLTHSAKSLDFSM  282

378) Cyan7822_4212 in NC_014501


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (573),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 108/255 (43%), Positives = 171/255 (68%), Gaps = 5/255 (1%)

Query  29   TTGGLNLQGTGKAVWIVKEAGVIAGLPMAARVFQLLDEKLSF--VPLATEGDKCEPGQKI  86
            T + ++ +G +K   + KEAGV+AGL +  RVF L+D  ++F       +GD+  +G+ +
Sbjct  32   TNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLV  91

Query  87   AQIEGLLEALLMGERVALNIAMRLSGIATLTRQYIEIIADLPTQLVDTRKTTPGLRLLEK  146
             +I G + +LL  ERVALN+  +LSGIA++T  Y+E ++D   ++ DTRKTTP LRL+EK
Sbjct  92   LEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEK  151

Query  147  YATQLGGAVNHRMGLDDAVMIKDNHIQAAGGIETAIAKIRSSIPYPLtvevettnleevk  206
            YA ++GG+ NHR  L DA+M+KDNHI A G+++ AIA+ R+  P+   VEVE  +L    
Sbjct  152  YAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAE  211

Query  207  eALSGGADLIMLDNMTLEQMQQAVQVIRERNNKTKIEASGNITLHNLRSVALTGVDYIST  266
            EA ++G D+IMLDNM+LEQ++QA+ +I     +++IE SGNI +  +      ++DY+S+
Sbjct  212  EAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRFRGLAIDYVSS  268

Query  267  SATITRSTWLDLSMR  281
            ++    +  LD+SM+
Sbjct  269  GSLTHSAKSLDFSMK  283

379) EAT1b_2689 in NC_012673


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (573),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 114/270 (43%), Positives = 181/270 (68%), Gaps = 7/270 (2%)

Query  6    LREQLRQFLIEDIGYGDLSSALIDGQDESVATIVAKEQGIFCGKPIVEELATM--QRLEL  63
            L+  LR+  ++  +Y+  ++A++D ++++  ++ AKE G++ G  + + + T+    + +
Sbjct  17   LKAALRE-DVHSEDYS--TNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  64   VSCQE--DGRAVTPGDELVVLRGKTRAILETERVLLNVIQHTSGIATMTRQCVDALHDDS  121
             + ++  DG  +T+GD ++ + G  R++L  ERV LN +QH SGIA+MT   V+AL DD 
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  122  IHVTDTRKTTPGLRMIEKYAVRVGGGYNHRLRLDDAVMIKDNHIVALGGVTNAIQVARER  181
            I V DTRKTTP LR++EKYAVRVGGGYNHR+ L DA+M+KDNHI A+G+V +AI  AR  
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  182  VGHTTPIEVEVESFEQLMEAVQADPDIVMLDNRTPDELREWVRHIPTHIKIEVSGGITLD  241
                  +EVEVES+    EA  A+ DI+MLDN + +++ + +  I+ + +IE SG I + 
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  242  TIDDYRGIRIDVISLGQLTHSVRAFDCSLN  271
            TI  +RG+ ID +S G LTHS +++D S++
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

380) Bacsa_3371 in NC_015164


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (572),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 111/267 (42%), Positives = 178/267 (67%), Gaps = 8/267 (2%)

Query  20   EDIGDGDHTTLSCIPADAMGKSKLLIKEEGILAGIEVAKEVFRRFDP--TLQVEVFINDG  77
            ED+   D +T + +  ++ +K  L+ KE G+LAG+ V + VF  FD+  T+Q    ++DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  78   THVKPGDVPMVVSGKVQSLLQTERLMLNIMQRMSGIATMTHKYVERLAGTKTRVLDTRKT  137
             ++ +GD+ + + G V+SLL  ER+ LN++Q++SGIA+MT  YVE L++ + +V+DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  138  TPGMRILEKMAVKIGGGVNHRIGLFDMILLKDNHVDFAGGIDKAILRAKEYCK-VKGKDL  196
            TP +R++EK AV++GGG NHR+ L D I+LKDNH+   G+++KAI +A+ Y   VK    
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK----  198

Query  197  KIEIEVRNLDELQQVLDLGGVDRIMLDNFTPADTRKAVEMVGGRYEIESSGGITFDTLRD  256
             +E+EV +L    +    +GVD IMLDN +  +  +A+ +++GR  IE SG I   T+  
Sbjct  199  MVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISR  257

Query  257  YAECGVDFISVGALTHSVKGLDMSFKA  283
            +   ++D++S G+LTHS K+LD S K+
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFSMKG  284

381) SCD_n01136 in NC_022357


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (572),  Expect = 2e-39, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 188/278 (68%), Gaps = 6/278 (2%)

Query  2    DLTA-HVESNVEAALVEDIGSGDLTAQLIPTGQ-EARSTIISREAAVLCGVAWFEACFRR  59
            DLT+ +++  + AAL ED+ S D +++ I   + +A+ +++++EA+VL G++ F+  F  
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  60   LDAEVEIKW---FARDGEAVAAGQTLAEISGNARALLSAERPALNFLQTLSATATATRQY  116
            +DAEV ++    F +DG+ +++G+ + EI G+ R+LL+ ER ALNFLQ LS+ A+ T  Y
Sbjct  67   FDAEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  117  VDLIRDTHAKIMDTRKTLPGLRVAQKYAVKCGGGENQRVGLYDGILIKENHILAAGGVRE  176
            V+ + D + K+ DTRKT P LR+ +KYAV+ GGG N+R  L D+I++K+NHI A G+V+ 
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  177  ALTQATNIATAGISIQIEVESLDELDQALAAGAKLILLDNFNLESLRAAVKLAGTRAELE  236
            A++QA   A     +++EVESL   ++A AAG  +I+LDN +LE +  A+ L + R+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  237  ASGGITLETVRAIAETGVHRISIGSLTKDIKAVDLSMR  274
             SG I + T+  +   +++ +S GSLT   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

382) Cylst_0269 in NC_019757


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (571),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 105/230 (46%), Positives = 151/230 (66%), Gaps = 5/230 (2%)

Query  58   LPVAGRVFQLLNEKVRFVAIAD--EGARCEPGQVVAEIHGSLDALLMGERVALNLAMRLS  115
            L V  RVF L++  V F    +  +G R  +G++V EI GS+ +LL  ERVALN+  +LS
Sbjct  57   LTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLS  116

Query  116  GIATLTNIYIEKIADLPPRLVDTRKTTPGLRLLEKYATAVGGAINHRMGLDDAVMIKDNH  175
            GIA++T  Y+E ++D   ++ DTRKTTP LRL+EKYA  VGG+ NHR  L DA+M+KDNH
Sbjct  117  GIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNH  176

Query  176  IAAAGGIGEAVTRVRSQIPYPLTIEVETESLEQVWEALQHKADIIMLDNMPLEMMREAVQ  235
            IAA G++  A+++ R+  P+   +EVE ESL    EA     DIIMLDNM+LE + +A+ 
Sbjct  177  IAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAIT  236

Query  236  LIRQQDSGVKIEASGNVTLETIRAVAETGVDYISSSAPITQSKWLDLSMR  285
            LI  +    +IE SGN+ + TI      ++DY+SS++    +K LD+SM+
Sbjct  237  LIAGRS---RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

383) Geoth_1040 in NC_015660


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (571),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 111/261 (43%), Positives = 174/261 (67%), Gaps = 6/261 (2%)

Query  16   EDIGERDITSETIFPDNEWAAGTFTAKEDGVLAGTDIIVTGYRLLHPDIDVTLHK----R  71
            ED+   D ++++IF ++  A  ++ AKE GVLAG  ++   + L+  D +VT+++    +
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF--DAEVTFQNPHQFK  80

Query  72   DGEQIKKGETIAAASGPVAPLLAGERVILNLLQRMSGIATLTHQAVMALNSSHTRICDTR  131
            DG+++  G+ +    G+V +LL+ ERV LN+LQ++SGIA++T   V AL   + ++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  132  KTTPGLRMLEKHAVVCGGGYNHRFGLYDGVMIKDNHIAFCGSITKAVQAVRAKLGHMVKI  191
            KTTP LR++EK AV  GGGYNHRF L D++M+KDNHIA  GS+ KA+   RA    +  +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  192  EVETETKAQVLEAVKAGVDVIMFDNRTPEEVREFVSLVPKPIVTEASGGITLENLAAYGA  251
            EVE E+ A   EA  AGVD+IM+DN + E++ + ++L++     E SG I +  ++ + +
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  252  TGVDYISLGMLTHSAKSLDIS  272
             ++DY+S G LTHSAKSLD+S
Sbjct  261  LAIDYVSSGSLTHSAKSLDFS  281

384) nadC in NC_008095


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (571),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 103/243 (43%), Positives = 162/243 (67%), Gaps = 3/243 (1%)

Query  36   EGSAELVAKEQLVLAGLDAFVRVFKTVDPNVEVELLR--RDGQEIKPKMVAARCHGRMRS  93
            ++   L AKE  VLAGL  F RVF   D++V  +  +  +DG+ + +  +     G +RS
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  94   LLAAERTALNIVQRAAGIATLAQQAVTSVRGSNLRVLDTRKTPPGMRTVAKEAVRMGGAS  153
            LL+ ER ALN++Q+ +GIA+++   V ++ +  ++V+DTRKT P +R   K AVR+GG+ 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  154  NHRFGLFDGVLIKDNHIAAVGGSIAEALRRAKLNGPRLTKVEIEVTNLKQLAEAIEHGAD  213
            NHRF L D++++KDNHIAAV GS+  A+ +A+  +P +  VE+EV +L    EA   G D
Sbjct  161  NHRFNLSDAIMLKDNHIAAV-GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVD  219

Query  214  VVMLDNMDDAQIREAVKLAAGRVPLEVSGGVTLDRLPRLAKLGIDFVSMGALTHSARAMD  273
            ++MLDNM   QI +A+ L AGR  +E SG + +  ++R+  L+ID+VS G+LTHSA+++D
Sbjct  220  IIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD  279

Query  274  LSL  276
            +S+
Sbjct  280  FSM  282

385) Cpin_0473 in NC_013132


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (570),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 186/278 (67%), Gaps = 8/278 (2%)

Query  7    LTELIRNALAEDIGNGDHSTLACIPADARGGARLKIKEDGILAGMEVAQAVFQMLDSNSI  66
            + + ++ AL ED+ + D ST A +  ++++   L  KE G+LAG+ V Q VF ++D++  
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   F---RPFKKDGDVMKSGEIAFEVDASIHTLLMGERLVLNCMQRMSGIATLTRSYVDVLKG  123
            F   + FK DGD + SG++ +E+ +S+++LL  ER+ LN +Q++SGIA++T +YV+ L +
Sbjct  73   FQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  124  YHTRLLDTRKTTPNFRLLEKEAVRIGGGVNHRMGLYDMVMLKDNHIDFAGGITAAVTKTV  183
             + +++DTRKTTPN+RL+EK AVR+GGG NHR  L D +MLKDNHI   G++  A++++ 
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  184  AYLQQQQLPLQIEVETRNLEDVKEVLAIGQIHRIMLDNFSPALLKEALALIDGRYETEAS  243
            AY     +   +EVE  +L    E  A G ++ IMLDN S   + +A++LI GR   E S
Sbjct  192  AY---APFVKMVEVEVESLAAAEEAAAAG-VDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  244  GGINLDTLEAYAKTGVDYVSAGAVIHHAVSLDLSLKAI  281
            G I++ T+  +   ++DYVS+G++ H A SLD+S+K++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

386) ambt_02290 in NC_015554


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (571),  Expect = 3e-39, Method: Compositional matrix adjust.
 Identities = 116/283 (41%), Positives = 199/283 (71%), Gaps = 5/283 (1%)

Query  1    MISPDINAIREQVSLALIEDLGGELNAHNDITANLIDESENATATIITREQCVICGVAWV  60
            +IS D+ ++  Q+  +L   L  ++++++  T  ++D+  +A  +++++E  V+ G++  
Sbjct  3    IISTDLTPF--QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  61   EQAFALIDERLEL--VWQVKDGDTVAADttlltltGSARAILTAERVALNFLQTLSATAT  118
            ++ F+L+D  + +    Q KDGD ++++  +L + GS R++LT ERVALNFLQ LS+ A+
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  119  VTASYAKLLAGSNTKILDTRKTLPGLRMAQKYAVHCGGGQNHRIGLFDAFLIKENHIFSC  178
            +TA+Y   L++   K++DTRKT P LR+ +KYAV+ GGG NHR+ L DA+++K+NHI + 
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  179  GSIEKAISRAKEMKP-GKPvevevesleelqqallaGADIVMLDNFTNEQIQKAVALTQG  237
            GS++KAI++A+   P  K VEVEVESL   ++A  AG DI+MLDN + EQI++A++L  G
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  238  QCKLEVSGNITDERLSSLATLGVDYISSGALTKNVKAIDLSLR  280
            + ++E SGNI    +S +  L++DY+SSG+LT + K++D+S++
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

387) LILAB_30425 in NC_015711


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (570),  Expect = 4e-39, Method: Compositional matrix adjust.
 Identities = 103/243 (43%), Positives = 164/243 (68%), Gaps = 3/243 (1%)

Query  36   EGSAELVAKEQLVLAGLEAFVRVFKMVDPNVEVELLR--RDGQEIKPKMVAARCHGRMRS  93
            ++   L AKE  VLAGL  F RVF + D++V  +  +  +DG+ + +  +     G +RS
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  94   LLAAERTALNIVQRAAGIATLAQQAVTSVRGSKLRVLDTRKTPPGMRTVAKEAVRMGGAS  153
            LL+ ER ALN++Q+ +GIA+++   V ++ + +++V+DTRKT P +R   K AVR+GG+ 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  154  NHRFGLFDGVLIKDNHIAAVGGSISEALRRAKLNGPRLCKVEIEVTNLKQLAEAIEHGAD  213
            NHRF L D++++KDNHIAAV GS+  A+ +A+  +P +  VE+EV +L    EA   G D
Sbjct  161  NHRFNLSDAIMLKDNHIAAV-GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVD  219

Query  214  VVMLDNMDDAQIREAVKLAAGRVPLEVSGGVTLDRLPRLAKLGIDFVSMGALTHSARAMD  273
            ++MLDNM   QI +A+ L AGR  +E SG + +  ++R+  L+ID+VS G+LTHSA+++D
Sbjct  220  IIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD  279

Query  274  LSL  276
            +S+
Sbjct  280  FSM  282

388) SBI_05945 in NC_016582


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  155 bits (570),  Expect = 5e-39, Method: Compositional matrix adjust.
 Identities = 116/272 (43%), Positives = 182/272 (67%), Gaps = 3/272 (1%)

Query  56   KVEDIAHMAIEEDLDHGVDVTTVATIPEDAMATGDFTAREAGIVAGLRVAEAVLSIVCTD  115
            +++D    A+ ED+ H+ D +T A + +++ A   + A+EAG++AGL V + V+++  ++
Sbjct  12   QIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  116  -EFEVERHVEDGDRVAAGQQLLSVRTRTRDLLTAERSALNLLCRLSGIATATRAWADALE  174
              F+  ++  DGDR+++G+ +L +    R LLT ER ALN+L +LSGIA+ T A  +AL 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  175  GTTAKVRDTRKTTPGLRVLEKYAVRCGGGVNHRMSLSDAALVKDNHVVAAGGVAQAFKAV  234
            +   KV DTRKTTP LR++EKYAVR GGG NHR +LSDA ++KDNH+ A G+V +A+   
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  235  RAEFP-dvdvevevdTLDQIPPVLDAGADLILLDNFTLEQTRQAVELVAGRATLESSGRL  293
            RA  P    VEVEV++L        AG D+I+LDN +LEQ  QA+ L+AGR+ +E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  294  TLANARAYGETGVDYLAVGALTHSSPILDIGL  325
             ++    +   ++DY++ G+LTHS+  LD+++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

389) nadC in NC_021505


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (569),  Expect = 4e-39, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 194/278 (70%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGDRATANQPLFHLEGPARSLLSGERSALNFLQMLSGVATRARFL  122
             +D+ V+ +   Q  DGDR T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVEGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIAASGGVAE  182
             + + + +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AVTAAHRIAP-GKPVEIEVESLDELREALAAGADIIMLDELNLDEMREAVRINAGKAKLE  241
            A++ A+  AP  K VE+EVESL    EA AAG DIIMLD+++L+++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

390) nadC in NC_020449


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (568),  Expect = 5e-39, Method: Compositional matrix adjust.
 Identities = 120/271 (45%), Positives = 181/271 (67%), Gaps = 5/271 (1%)

Query  12   IDEIIRKGLEEDIGSGDITTR-YLDLEPQNNIAYIIPKEEGVLAGVDVARLVFRMVDPEL  70
            ID+ ++ +L ED+ S D +T   +D + Q +++ +++KE GVLAG+ V + VF + D+E+
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVS-LFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   KIVLYN--KDGDKIMPNEEIMRLEGRPSSILQGERTALNFLQRLSGIATKTAKFVSLLEG  128
             +   +  KDGD++ + + ++ + G   S+L  ER ALNFLQ+LSGIA+ TA +V  L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TNVKLLDTRKTTPLLRSLEKYAVRVGGGYNHRFGLFDMVLIKENHIRACGSITEAVNRIR  188
              +K++DTRKTTP LR +EKYAVRVGGGYNHRF L D +++K+NHI A GS+  A+ + R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  KHNTSYK-IEVEVTNLKEVDEAAKAKVDRVMLDNMTPTQIRKAVKKYKDILEFEVSGGIT  247
                  K +EVEV +L   +EAA A VD +MLDNM+  QI +A+    +   +E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EENIRSFAETGVQFISSGALTHSYKSLDISL  278
               I  F   +++++SSG+LTHS KSLD+S+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

391) Mbur_1682 in NC_007955


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (568),  Expect = 5e-39, Method: Compositional matrix adjust.
 Identities = 106/248 (43%), Positives = 165/248 (67%), Gaps = 11/248 (4%)

Query  29   EIKAIVFVKQDCIIAGIPIAKRIFDYFG----LDSSAKYKDGDQLGSGDTILEISGNAVS  84
            + K  +F K+  ++AG+ + +R+F  F+    ++++ ++KDGD+L SGD +LEI G+  S
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  85   VLRAERIVLNFLGHLSGIATNTREYVETVRQYSDVKVAGTRKTTPGIRKFEKLAIIAGGG  144
            +L  ER+ LNFL HLSGIA+ T  YVE++ +   +KV +TRKTTP +R FEK A+  GGG
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGD-DRIKVFDTRKTTPNLRLFEKYAVRVGGG  159

Query  145  DPHRFDLSDTIMIKDNHVNMMG-LENAINSAKELAGFTQKIDVEVESVENAILAAKMGVD  203
              HRF+LSD+IM+KDNH+  +G +++AI  A+  A F + ++VEVES+  A  AA  GVD
Sbjct  160  YNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVD  219

Query  204  IIMFDNMSPGQVIKVVEALKNEDLRNSAILEVSGGIDISNISEYAKTGVDVISVGSLVHK  263
            IIM+DNMS  Q+ + +  +        + +E SG ID++ IS +   ++D +S GSL H 
Sbjct  220  IIMLDNMSLEQIEQAITLIA-----GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHS  274

Query  264  SQWIDVSL  271
            ++ +D S+
Sbjct  275  AKSLDFSM  282

392) nadC in NC_016812


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (569),  Expect = 5e-39, Method: Compositional matrix adjust.
 Identities = 119/294 (41%), Positives = 195/294 (67%), Gaps = 17/294 (5%)

Query  24   LRPELPALMVEEQVKTALLEDLGRAGDITTLATIGPDMTATATMSVREAGVVAGLELART  83
            +  +L ++ +++ +K+AL ED+ ++ D +T A ++ +  A  ++  +EAGV+AGL + + 
Sbjct  4    ISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  84   AFRLVDPSIRFEA--LVADGDRVAPGTTIARIFGRARGVLSGERVALNFLMHLSGIASYT  141
             F L D+ + F+      DGDR+++G  +  I+G  R++L+ ERVALNFL HLSGIAS T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  142  AKFADEIAHTAAKVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHiavsgg  201
            A + + +++   KV  TRKT P LR +EKYAVR+GGG NHR+ L DA+++KDNHIA  G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  202  vagairaaraYCGHLVKVEVEVDGLAQMREALTAAPDVILLDNMGPDLLREAVAVNAGHW  261
            V  AI  ARAY   +  VEVEV++LA   EA +A+ D+I+LDNM+ + + +A+++ AG  
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG--  240

Query  262  GLSAAAYADDPRRTRLEASGNVNIETIRAIAETGVDYISTSKITMAAPTLDIGL  315
                        R+R+E SGN+++ TI  +   ++DY+S++ +T +A +LD+++
Sbjct  241  ------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

393) Tter_1549 in NC_013525


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (569),  Expect = 5e-39, Method: Compositional matrix adjust.
 Identities = 112/275 (41%), Positives = 182/275 (67%), Gaps = 8/275 (2%)

Query  8    VREIVKNALHEDLGNGDLTSEATIPEDLEACGKIIAREDMVVAGLEVAKATFEEVLGNNL  67
            + + +K AL+ED+ + D +++A + ++ +A   ++A+E  V+AGL V +  F  +++ ++
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT-LFDAEV  71

Query  68   IFES---FTNNGCAIRADTCIGYVKGSARGLLAAERVALNFLMRLCGIATLTRQYVEAVK  124
             F++   F + +    +D  +  + GS R+LL+ ERVALNFL +L GIA++T  YVEA+ 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLE-IIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  125  GTKAKIVDTRKTTPGLRTLEKAAVVAGGGNNHRFGLYDGILIKDNHISLAGGVEQAIRAA  184
            + + K+ DTRKTTP LR +EK AV  GGG NHRF L D+I++KDNHI+  G+V++AI  A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  185  RSRATHTLRIEVEVEDMDQLHEALRAGADVILLDNMSPAQVKEATQLIKSFDNRIIVEVS  244
            R+ A     +EVEVE +   +EA  AG D+I+LDNMS  Q+ +A  LI     R  +E S
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECS  247

Query  245  GGINLSNVRDYAEAGVDIISVGALTHSARAMDISL  279
            G I+++ +  +   ++D +S G+LTHSA+++D+S+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

394) nadC in NC_014623


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (567),  Expect = 6e-39, Method: Compositional matrix adjust.
 Identities = 113/240 (48%), Positives = 167/240 (70%), Gaps = 7/240 (2%)

Query  11   LVAKEQMVLAGLGAFARVFHHVDPEVKVE----FLRHDGEEVKPKTVTARVSGRLRSLLA  66
            L AKE  VLAGL  F RVF   D+EV  +    F   DG+ + +  +   + G +RSLL+
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF--KDGDRLTSGDLVLEIIGSVRSLLT  103

Query  67   AERTALNIVQRMSGIATLARQAVAAVRGSKLQILDTRKTTPGLRGLSKEAVRLGGASNHR  126
             ER ALN++Q++SGIA+++   V A+ + +++++DTRKTTP LR + K AVR+GG+ NHR
Sbjct  104  CERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  127  FGLFDGILIKDNHIAAVGGSIQEalrraranaprlVKIEIEVTNLQQLAEAVAEGADVVM  186
            F L D+I++KDNHIAAV GS+Q A+ +ARA AP +  +E+EV +L    EA A G D++M
Sbjct  164  FNLSDAIMLKDNHIAAV-GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIM  222

Query  187  LDNMDDELIRQSVQLSAGRVPLEVSGGVTLERLPRLAKLGVDFVSLGALTHSARSMDLSL  246
            LDNM  E I Q++ L AGR  +E SG + +  ++R+  L++D+VS G+LTHSA+S+D+S+
Sbjct  223  LDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

395) vfu_A00873 in NC_016602


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (568),  Expect = 6e-39, Method: Compositional matrix adjust.
 Identities = 109/271 (41%), Positives = 178/271 (66%), Gaps = 3/271 (1%)

Query  26   VTDTLKEDLGGTLDPAADITASLIPADVQGNATIITREHGVFCGQAWADEVFKQLGGEVT  85
            + DTLK  L   +++    T +++  + Q++ +++++E GV+ G +  + VF  +++EVT
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  86   IE--WLVKDGDPVVPNQTLCTLSGPARILLTGERNAMNFIQTLSGCATTTATYVKALEGT  143
            ++     KDGD + + + +  + G+ R LLT ER A+NF+Q LSG A+ TA+YV AL + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  144  GCRLLDTRKTIPGLRSALKYAVACGGGFNHRIGVFDAYLIKENHIIACGGITQAISTAKQ  203
              +++DTRKT P LR   KYAV  GGG+NHR+ + DA ++K+NHI A G++ +AI+ A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  204  LNP-GKPVEVETENLDELRLAIEAGADIIMLDNFTLEMMRDAVAINAGRAALENSGNVTM  262
              P  K VEVE E+L     A  AG DIIMLDN +LE + +A+++ AGR+ +E SGN+ M
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  263  ETLREYAETGVDYISVGALTKHVRAMDLSMR  293
             T+  +   ++DY+S G+LT   +++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

396) nadC in NC_005966


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  154 bits (567),  Expect = 7e-39, Method: Compositional matrix adjust.
 Identities = 111/271 (41%), Positives = 183/271 (68%), Gaps = 4/271 (1%)

Query  20   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIITRENMILAGRPWVDALITRYDASVQ  78
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  +LAG    + ++T +DA V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  79   IEWLKQ--EGEQVAAGEAFLKLAGSARSLLTVERPALNFVQTLSAVATKAAFYVQQLEGL  136
            ++   Q  +G+++++G+  L + GS RSLLT ER ALNF+Q LS++A+ +A YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  137  HTKLLDTRKTLPGLRIAQKYAVALGGGQNHRLGLFDAFLIKENHIMAAGGIAQAIEKAHQ  196
            + K++DTRKT P LR+ +KYAV +GGG NHR+ L DA+++K+NHI A G++ +AI +A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  197  IAP-GKPVEVEVETWDELDQALQAGADIVMLDNFSQQQMIEAVKYVAGRCKLEASGNITL  255
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  256  DNLREVASTGVDYISMGVLTKDVTAIDLSMR  286
              +    + ++DY+S G LT    ++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

397) TTHA0985 in NC_006461


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (563),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 127/281 (46%), Positives = 198/281 (71%), Gaps = 2/281 (0%)

Query  3    GVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEGGVLAGLWVAE  62
            ++++  L    ++++L+A LRED+   D ++  +  ++ ++   ++AKE+GVLAGL V +
Sbjct  2    SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  63   RVFALADPRTAF--TPLVAEGARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATL  120
            RVF+L D+  +F       +G R++ G  V  + G++R++L+ ER+ALN+LQ+LSGIA++
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  121  TRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRNHRYGLFDGILLKENHvraag  180
            T AYVEAL++ + +++DTRKTTP LR +EKYAVRVGGG NHR+ L D+I+LK+NH+ A G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  181  gvgeavrrakaraPHYlkvevevrsleeleealeagadlillDNFPLEALREAVRRVGGR  240
            +V  A+ +A+A AP    VEVEV SL   EEA  AG D+I+LDN +LE + +A+  ++GR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  241  VPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSL  281
              +E SGN+ +         ++DYVS G+LTHSAK+LD+S+
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

398) O159_19020 in NC_022438


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (563),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 107/247 (44%), Positives = 167/247 (68%), Gaps = 7/247 (2%)

Query  36   ASARLAAREPGIFAGGEVFAAAMRLTDPGI--QIVLTVADGDAFEPGDTLATVSGPAGSV  93
            A   L A+E+G++AG  VF     L D+ +  Q      DGD + +GD +  + G+  S+
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  94   LTAERVALNFAQRMSGIATLTASFVYAVAHTSARIVDTRKTTPGLRAFERHAVRCGGGGN  153
            LT ERVALNF Q++SGIA++TA++V A+++   ++ DTRKTTP LR FE+ AVR GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  154  HRFSLSDAVMVKDNHLAVLTAQSGLSVTDALKKVRRELSHTTHLEVEVDRLDQIESVLAA  213
            HRF+LSDA+M+KDNH+A +      SV  A+ + R   +    +EVEV+ L   E   AA
Sbjct  162  HRFNLSDAIMLKDNHIAAVG-----SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAA  216

Query  214  GVDTIMLDNFTLEQLREGVAIVGGRAIVEASGTVSLSTVRAIAETGVDIISAGALTHSGR  273
            GVD IMLDN +LEQ+ +++++++GR+ +E SG + ++T+  +   ++D +S+G+LTHS++
Sbjct  217  GVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK  276

Query  274  SLDLGLD  280
            SLD+++ 
Sbjct  277  SLDFSMK  283

399) Xcel_0348 in NC_013530


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (563),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 123/281 (44%), Positives = 186/281 (67%), Gaps = 7/281 (2%)

Query  1    MTPVAAVDEILTHALAEDAPWGDLTSEVFLPagarakaalvaREPGVLSGLTVFARTFTL  60
            +TP   +D+ L  AL ED    D +++ ++   ++AK +L A+E+GVL+GLTVF R FTL
Sbjct  8    LTPFQ-IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  61   LDPAAVVELPTA--DGAEFAAGDVLAVVEGDARAVLRAERIGLNLVQRLSGIatttaryv  118
            +D+    + P    DG  +++GD++  + G  R++L  ER++LN++Q+LSGIA+ TA YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  119  avvagtgarvvdtRKTTPGLRVLERAAVRDGGGHNHRFSLSDAVMAKDNHLAVLAAQGIS  178
              +++   +V DTRKTTP LR++E+ AVR GGG NHRF+LSDA+M KDNH+A ++    S
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----S  182

Query  179  VGDAIRAARAKLPHTATIEVEVDRLDQIEEVVAAGVTTIMLDNFTPAELVAGIEIVAGRA  238
            V  AI  ARA  P    +EVEV+ L   EE  AAGV  IMLDN +  ++  +I ++AGR+
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  239  IVEASGGITLDTIRAVAETGVDVISVGALTHGVRSLDLGLD  279
             +E SG I + TI      ++D +S G+LTH+ +SLD+++ 
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

400) BATR1942_11695 in NC_014639


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (564),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 118/275 (43%), Positives = 186/275 (68%), Gaps = 3/275 (1%)

Query  1    MDRLQLKKMLKYFFQEDIGTGDLTSQAIFSGHS-CEAFIIAKSNGIFAGGSIIKEGYALI  59
            +  +Q+   LK  ++ED+ + D +++AIF  H+     ++AK  G++AG ++++  ++L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   DKEV--RTVLKKEDGDTVRKGDaiaalsgpaaallTGERVILNLIQRLSGIATMTKQAVD  117
            D EV  +   +  DGD +  GD +  + G+  +LLT ERV LN++Q+LSGIA+MT   V+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  118  RLDDPSIKLCDTRKTTPGLRMLEKYAVRVGGGYNHRFGLYDGMMIKDNHIAACGSIQKAC  177
             L+D  IK+ DTRKTTP LR++EKYAVRVGGGYNHRF L D++M+KDNHIAA GS+QKA 
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  178  ERARRAAGHMVNIEVEIESEEQLREAILAGADVIMFDNCPPDTVRHFAEITPHHIKTEAS  237
             +AR  A  +  +EVE+ES     EA  AG D+IM+DN + + + +   + + + + E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  238  GGISLEILPSYKGTGVQFISLGCLTHSVQSLDISM  272
            G I +  ++ ++G +++++S G LTHS +SLD+SM
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

401) nadC in NC_005773


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (564),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 119/278 (43%), Positives = 198/278 (72%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALFEDVGSGDITAQLIPAER-LAKATIISRDAAVIAGTAWVDTVFR  64
            +DLT+ +I+  ++ AL EDV S D +++ I  ++  AK ++++++A+V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVTDGDRVSPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQYF  122
             +D+ V+ +   Q  DGDR+++ + ++++ G+ RSLLT ER ALNFLQ LSG+A+ +  +
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADMVSGTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIAQ  182
             + +++ ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AVEAAHRIAP-GKPveveveslselKQALDAGADIIMLDELSLEDMREAVRLTAGRARLE  241
            A+  A+  AP  K VEVEVESL+   +A  AG DIIMLD++SLE++ +A+ L AGR+R+E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG I+  T+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

402) MADE_1015005 in NC_011138


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (565),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 113/272 (42%), Positives = 193/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYVKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA YV  L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

403) nadC in NC_006270


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (565),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 114/277 (42%), Positives = 178/277 (65%), Gaps = 4/277 (1%)

Query  1    MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLL  60
            +  F + + LK  ++ED+   D +++A+FD++ Q    + AK+ G++AG  V+   F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DETIAV---HMLKTDGEAVRKGETIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSI  117
            D  ++    H +K DG+ +  G+ +  + G   SL+T ERV LN++Q++SGIA++T   +
Sbjct  68   DAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  118  IRLNDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGGIMIKDNHIAACGSISKA  177
              L D  I + DTRKTTP LR++EKYAV+ GGG NHRF L ++IM+KDNHIAA GS+ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  178  VEKARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEA  237
            + +AR+    +  +EVE+ES    +EA  AG DIIM+DN + E +     + ++    E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  238  SGGISFENLPAYRGTGVHCISLGYLTHSAKSLDISMN  274
            SG I    ++ +RG +++ +S G LTHSAKSLD+SM+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

404) nadC in NC_006322


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (565),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 114/277 (42%), Positives = 178/277 (65%), Gaps = 4/277 (1%)

Query  1    MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLL  60
            +  F + + LK  ++ED+   D +++A+FD++ Q    + AK+ G++AG  V+   F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DETIAV---HMLKTDGEAVRKGETIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSI  117
            D  ++    H +K DG+ +  G+ +  + G   SL+T ERV LN++Q++SGIA++T   +
Sbjct  68   DAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  118  IRLNDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGGIMIKDNHIAACGSISKA  177
              L D  I + DTRKTTP LR++EKYAV+ GGG NHRF L ++IM+KDNHIAA GS+ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  178  VEKARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEA  237
            + +AR+    +  +EVE+ES    +EA  AG DIIM+DN + E +     + ++    E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  238  SGGISFENLPAYRGTGVHCISLGYLTHSAKSLDISMN  274
            SG I    ++ +RG +++ +S G LTHSAKSLD+SM+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

405) GY4MC1_0970 in NC_014650


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (564),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 109/260 (42%), Positives = 173/260 (67%), Gaps = 4/260 (1%)

Query  16   EDIGERDITSETIFPDNEWAAGTFTAKEDGVLAGTDIIVTGYRLLHPDI---HVTLYKRD  72
            ED+   D ++++IF ++  A  ++ AKE GVLAG  ++   + L+++++   +   +K D
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK-D  81

Query  73   GEQIKKGETIAAASGPVAPLLAGERVILNLLQRMSGIATLTHQAVMALNSSHTRICDTRK  132
            G+++  G+ +    G+V +LL+ ERV LN+LQ++SGIA++T   V AL   + ++ DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  133  TTPGLRMLEKHAVVCGGGYNHRFGLYDGVMIKDNHIAFCGSITKAVQAVRAKLGHMVKIE  192
            TTP LR++EK AV  GGGYNHRF L D++M+KDNHIA  GS+ KA+   RA    +  +E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  193  VETETKAQVLEAVKAGVDVIMFDNRTPEEVREFVSLVPKPIVTEASGGITLENLAAYGAT  252
            VE E+ A   EA  AGVD+IM+DN + E++ + ++L++     E SG I +  ++ + + 
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGL  261

Query  253  GVDYISLGMLTHSAKSLDIS  272
            ++DY+S G LTHSAKSLD+S
Sbjct  262  AIDYVSSGSLTHSAKSLDFS  281

406) Aazo_2134 in NC_014248


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (564),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 116/281 (42%), Positives = 185/281 (66%), Gaps = 7/281 (2%)

Query  8    LPPFLVLDQLLQTWLVEDIGRGDRTTQSLLCQNATIGQAQWiakapgiiaglpiaaRVFQ  67
            L PF + D+ L++ L ED+   D +T++++ +++  ++   +AK +G++AGL +  RVF 
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFT  65

Query  68   LLNDQVSFVAVS--SEGAKCEPGQVVAKINGSLDALLMGERVALNLVMRLSGIATLTNIY  125
            L++ +V+F       +G +  +G++V  I GS+ +LL  ERVALN++ +LSGIA++T  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  126  VEKIADLPARFVDTRKTTPGLRILEKYATAVGGGINHRIGLDDAVMIKDNHIVAAGDIGE  185
            VE ++D   +  DTRKTTP LR++EKYA  VGGG NHR+ L DA+M+KDNHI A G +  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  186  AITQIRSRIPYPLTIEVETESLEQVHSALEYQADIIMLDNMTVDIMAEAVQLIRQMDSRV  245
            AI+Q R+  P+   +EVE ESL   + A     DIIMLDNM+++ + +A+ LI    +R 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  246  KIEASGNVSLETIRGVAETGVDYISSSAPITQSRWLDLSMR  286
            +IE SGN+ + TI      ++DY+SS++    ++ LD+SM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

407) nadC in NC_014371


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (563),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 112/273 (42%), Positives = 180/273 (66%), Gaps = 10/273 (3%)

Query  15   AFSEDIGDGDHTTLCCIPADAKGESRLLIKEEGVLAGVNVAKRVFHLFDPDLQVEV---Y  71
            A+ ED+   D +T   +  ++++   L+ KE GVLAG+ V +RVF LFD+++  +    +
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  72   VEDGAHVKPGDIVMSVKGRTQSLLQTERLMLNILQRMSGIATMTNKYQQALIDAGTKTRV  131
              DG ++ +GD+V+ + G  +SLL  ER+ LN+LQ++SGIA+MT  Y +AL  ++ + +V
Sbjct  80   -KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKV  136

Query  132  LDTRKTTPGMRMLEKEAVKIGGGMNHRIGLFDMILLKDNHVDFCGGVHNAISMAKQYCKD  191
            +DTRKTTP +R++EK AV++GGG NHR+ L D I+LKDNH+   G+V++AI+ A+ Y   
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP-  195

Query  192  HGKNDLKIECEVRNFTELEEALNEGCDRIMFDNFTPEDTRKAVEMVAGRCETESSGGITF  251
              K    +E EV +++  EEA   G D IM+DN + E+  +A+ ++AGR   E SG I  
Sbjct  196  FVK---MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  252  DTMIPYAQAGVDFISFGALTHSVKGLDMSFKAV  284
             T+  +   ++D++S G+LTHS K+LD S K++
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

408) Nwi_2426 in NC_007406


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (563),  Expect = 1e-38, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 182/278 (66%), Gaps = 3/278 (1%)

Query  4    PALPRIMIEPLVRAALLEDLGRAGDLTTDAIVPVGHRTTAVIAARQQGTVAGLDLARLAF  63
              L  + I+  ++AAL ED+ ++ D +T+AI     ++   + A++ G +AGL + +  F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   ELIDPAIEMHAGHD--DGAIVAPGDVIATLSGPARGILTAERVALNFLCHLSGIatatas  121
             L+D+ +  +  H+  DG  +++GD++  + G+ R++LT ERVALNFL HLSGIA+ TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  122  vvaavQDYKAKIVCTRKTTPGLRAIEKYAVRAGGGGNHRFGLDDAVLIKDNHIVIAGGVT  181
             V A+ D + K+  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHI   G+V 
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  EALKRAKDRVGHLVKIELEVDTLHQLREALEQGVDAVLLDNMSPDTLREAVAMVAGRAVT  241
             A+ +A+     +  +E+EV++L    EA   GVD ++LDNMS + + +A++++AGR+  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  242  EASGRITPATAPAIASSGVDLMSIGWLTHSVGILDLGL  279
            E SG I  +T + + + ++D +S G LTHS   LD+++
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

409) Rfer_1318 in NC_007908


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (563),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 117/267 (44%), Positives = 182/267 (69%), Gaps = 6/267 (2%)

Query  27   ALEEDVGSGDL-TAGLIDPACHARAHVLAREAAVICGAPWAQAALQQVDPAIRLQ--WLV  83
            AL EDV S D  T +++D   +A+  ++A+EA+V+ G    Q  +   D+ + +Q     
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  84   LEGQRCEIDQVVLELQGPARALLTAERTVLNFLQLLSAVASKTAEYVAAVQSVPGSRAQI  143
             +G+R   +++VLE+ G+ R+LLT ER  LNFLQ LS++AS TA YV   +++ + R ++
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV---EALGDDRIKV  136

Query  144  VDTRKTLPGLRLAQKYAVRAGGGSNHRLGLYDALLIKENHIaaaggvakvlrraavlaPE  203
             DTRKT P LRL +KYAVR GGG NHR+ L DA+++K+NHIAA G+V K + +A   AP 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  204  AKFVEIEVETLAQLKEALDAGAGMVLLDNMTLAQLQEAVQLNAGRAVLEVSGGVNMSTVR  263
             K VE+EVE+LA   EA  AG ++++LDNM+L Q+++A+ L AGR+ +E SG ++M+T+ 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  264  AIASTGVDRISIGALTKDVKAIDFSMR  290
             + + ++D +S G+LT   K++DFSM+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

410) Dacet_1743 in NC_013943


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (566),  Expect = 7e-39, Method: Compositional matrix adjust.
 Identities = 115/264 (44%), Positives = 169/264 (65%), Gaps = 2/264 (0%)

Query  10   ALEEDIGTGDLTARAFRKQNKRGIFKYLAKDDFILCGTKSASLVFEELDEDINVRFYHE-  68
            AL ED+ + D ++ A+  ++ ++    +AK+  +L G      VF  +D ++  +  H+ 
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  69   -DGACLKKGEYFGEVEGPIYSILTGERTSLNFLQRLSGIATETASYVKELKGTNIRLLDT  127
             DG  L  G+   E+ G++ S+LT ER +LNFLQ+LSGIA+ TA+YV  L +  I+++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  128  RKTTPGWRVAEKYAVLTGGGHNHRMGLFDGVMLKDNHIDAAGGIKEAVDLVKRNIPSTVK  187
            RKTTP  R+ EKYAV  GGG NHR  L D++MLKDNHI A G+++ A+   +   P    
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  188  VEVEVRDHEEARQAAEYGADIIMLDNFAVEDIQKAIDIINKRAKIEISGGIRKENLKDYR  247
            VEVEV     A +AA  G DIIMLDN ++E+I++AI +I  R++IE SG I    +  +R
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  248  NLDIDYISVGALTHHATSVDISLK  271
             L IDY+S G+LTH A S+D+S+K
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

411) Tcr_1367 in NC_007520


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (566),  Expect = 7e-39, Method: Compositional matrix adjust.
 Identities = 113/273 (42%), Positives = 185/273 (68%), Gaps = 6/273 (2%)

Query  9    DLENNIKNALAEDVGPGDLTAGLIPDTR-QATAQVIAKEAAVICGRPWFDKVIQQVNPNI  67
            ++++ +K AL EDV + D ++  I D + QA   ++AKEA+V+ G   F++V+   ++++
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  68   EIEW---FCKEGQSVPVNTLVCELRGQANSILTAERSALNFLQTLSATATITRQYIEKLQ  124
             ++    F K+G+ +    LV E+ G   S+LT ER ALNFLQ LS+ A++T  Y+E L 
Sbjct  72   TFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  125  GSHTQLLDTRKTMPGLRLAQKYAVHCGGGTNHRIGLYDAILIKENHIMAAGSISQAVALA  184
            + + +++DTRKT P LRL +KYAV+ GGG NHR+ L DAI++K+NHI A GS+ +A+A A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  185  RQLHP-NKtvevetetldevKQAVDASADIIMLDNFSLHQLKEAVQQVNKKCKLEASGNV  243
            R   P  K VEVE E+L    +A  A+ DIIMLDN SL+Q+ +A+  +  + ++E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  244  ELPHLSELAETGVDYISTGAITKNVQAIDFSMR  276
            ++  +S +   ++DY+S+G++T + +++DFSM+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

412) nadC in NC_014500


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (566),  Expect = 8e-39, Method: Compositional matrix adjust.
 Identities = 114/271 (43%), Positives = 183/271 (68%), Gaps = 9/271 (3%)

Query  30   ALREDLGGDVSAERDITAQLLPAETQANAVIITREAGVFCGQRWLDEVFRQLGGHIAID-  88
            +L+  L  DV +E   T  ++  + QA+  ++++EAGV+ G   ++ VF  ++++++++ 
Sbjct  16   TLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  89   -WLVRDGDVLTENQPLCRLRGPSRILLTGERTALNFLQTLSGVATEVSRYVAQLAGTHTR  147
                +DGD LT  + +  + G+ R LLT ER ALNFLQ LSG+A+  + YV  L++ + +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  148  LLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIAAGSIKQAVEQAFQLRG  207
            ++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+ QA   R+
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA---RA  192

Query  208  DVP----VEVEVETLDELQQALSAGADIIMLDNFTLEGIREAVTLTHGRALLEVSGNVTL  263
              P    VEVEVE+L   ++A +AG DIIMLDN +LE I +A+TL  GR+ +E SGN+ +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  264  QTLPDYAATGVDYISVGALTKHVQALDLSMR  294
             T++ + + ++DY+S G+LT   ++LD+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

413) nadC in NC_007204


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (566),  Expect = 8e-39, Method: Compositional matrix adjust.
 Identities = 107/267 (41%), Positives = 181/267 (68%), Gaps = 3/267 (1%)

Query  18   VESALMEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMDLARLSFALIDEKIEFVA  77
            + +AL ED+ +  D +++A +  + QA++ + A++AGV+ G+ + +  F+L+D  + F  
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  78   --YINDGETVEAGAVLATVRGNARNLLTAERTALNFMTHLSGIATDTKKIVDSVADYPAQ  135
               ++DG+ + +G ++  + G+ R+LLT ER ALNF+ HLSGIA+ T   V++++D   +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  136  ITCTRKTIPGLRIVQKYAVRCGGGRNHRLGLDDAILIKDNHIAIAGDIKTAIEQAQQFAG  195
            +  TRKT P LR+ +KYAVR GGG NHR+ L DAI++KDNHIA  G ++ AI QA+ +A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  196  HLIPIEVEVDTLAQLEQALDAGVSLVLLDNMAPEVLLQAVAMCQGRAKTEASGGITPETV  255
             +  +EVEV++LA  E+A  AGV +++LDNM+ E + QA+++  GR++ E SG I   T+
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  256  QAVAKTGVDFIAMGYLTHSTTALDIGL  282
                  ++D+++ G LTHS+ +LD+++
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

414) DaAHT2_0818 in NC_014216


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  153 bits (565),  Expect = 9e-39, Method: Compositional matrix adjust.
 Identities = 120/272 (45%), Positives = 191/272 (71%), Gaps = 4/272 (1%)

Query  15   DLHRSLRSFLDEDLGRGDITGEAIFDRKSSGTAVFIAKEAMVLAGVEQLAPLIFQMVNRE  74
            +++ +L++ L ED+   D + +AIFD+ + +   ++AKEA VLAG+  +   +F + + E
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR-VFTLFDAE  70

Query  75   TS---CHPTADGRRVEAGEVIFKVSGPMRDLLAAERLALNLCQRLSGIATYTADFVAAVA  131
             +    H   DG R+ +G++++ + G++R LL+ ER+ALN+ Q+LSGIA+ TA +V A++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  132  GYPAKIMDTRKTTPGLRLLERYAVRAGGGVNHRFNLNDGILIKDNHiaaagsiaravarv  191
            +   K+ DTRKTTP LRL+E+YAVR GGG NHRFNL+D+I++KDNHIAA GS+ +A+A+ 
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  192  rEYNGPDLAVEVECETLAQVEEAMAVGVEIIMLDNMSPALMTRAVSMIGKQAITEASGGV  251
            R Y      VEVE E+LA  EEA A GV+IIMLDNMS   + +A+++I+ ++  E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  252  SLANVREIAACGVDRISIGALTHSAPAKDISM  283
             ++ +  + + ++D +S G+LTHSA + D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

415) Tsac_1151 in NC_017992


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (562),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 98/231 (43%), Positives = 156/231 (68%), Gaps = 2/231 (0%)

Query  45   DGIIAGIDVFLMVFNTFDKDIQY--VKYFKDGDAVKKGDLILETYGELNSCLKAERVALN  102
             G++AG+ VF  VF  FD ++ +     FKDGD +  GDL+LE  G + S L  ERVALN
Sbjct  51   AGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALN  110

Query  103  LMQRMSGIATYVRVLKNMISETKAQLTDTRKTMPGLRYFDKYAVLVGGGINHRYNLSDGV  162
            ++Q++SGIA+      + +++ + ++ DTRKT P LR F+KYAV VGGG NHR+NLSD++
Sbjct  111  FLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAI  170

Query  163  LIKDNHIKAAGGIKNALTMIKNSVSHTQKIEIEVETIHELKEALKYGADIIMLDNMTIGM  222
            ++KDNHI A G++++A++  +   +  + +E+EVE++    EA   G DIIMLDNM++  
Sbjct  171  MLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQ  230

Query  223  MKEAVEITNGKAILEASGNINEDNILQVAKTGVDIISVGAITHSVKALDIS  273
            + +A+ +  G++ +E SGNI+   I +    ++D +S G++THS K+LD+S
Sbjct  231  IEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

416) nadC in NC_014355


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (561),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 113/274 (42%), Positives = 182/274 (67%), Gaps = 6/274 (2%)

Query  9    IRNAVQLALDEDLDHGDVTTSALFPRSIQARAAIVAHQPITVAGVAVAREVF--LAVDPS  66
            I ++++ AL ED++  D +T+A+F +  QA+ ++ A ++  +AG++V + VF  +  + +
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  67   LRIVTTINDGVTVKPGAEVIVVRGDVRSLLMAERVAVNFLQRLSGIATLTAKFCAAVRKT  126
            ++    ++DG  + +G  V+ + G VRSLL  ERVA+NFLQ+LSGIA++TA +  A+   
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  127  ATAILDTRKTTPGLRALEKWAVHLGGGRNHRFSLGDGVLIKDNHLAVLRSTGIDVAGACR  186
               ++DTRKTTP LR +EK AV++GGG NHRF+L+D++++KDNH+A + S    +A    
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ---  189

Query  187  LARAGAPHGLRIEVEAKSLQEVKEALAGKADIILLDNMSAALVRQAVALIKKRALVEVSG  246
             ARA AP    +EVE  SL    EA A+  DII+LDNMS   + QA++LI  R+ +E SG
Sbjct  190  -ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  247  GITLQTVAGMAQAGVDFISVGALTHSAPAADLSL  280
             I + T++     ++D++S G+LTHSA + D+S+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

417) nadC in NC_011296


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (560),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 115/276 (42%), Positives = 189/276 (69%), Gaps = 6/276 (2%)

Query  6    IDELFKLSIIEDIGNGDITSQLIIPEDCKALAQIICKEDIILAGMPFVKRFFTILSSYFG  65
            ID+ +K ++ ED+ + D +++ I+ ++ +A   ++ KE  +LAG+   +R FT++ +   
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  66   FQPEQIYFEEYYKDGDFIKKSNVIASVKGNTRLLLAGERIALNLLQRLSGIATFTREFVK  125
            FQ  + +     KDGD +  ++++  + G+ R LL+ ER+ALN+LQ+LSGIA+ T  +V 
Sbjct  73   FQNPHQF-----KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  126  KVEDLPVKILDTRKTTPGLRFMEKYAVKIGGGINHRFALYDAVLIKDNHIKVVGSVREAV  185
             + D  +K++DTRKTTP LR+ EKYAV++GGG NHRF L DA+++KDNHI  VGSV+ A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  186  IKAKN-QCIHQkvevevknlkeleeAISAEADIIMLDNMNIEEMKKAVEIANGRVLLEAS  244
             +A+    + + VEVEV +L   EEA +A  DIIMLDNM++E++ +A+ +  GR  +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  245  GGVNLENIRNIALTGVDFISIGALTHSATAVDISMK  280
            G +++  I  +   ++D++S G+LTHSA ++D+SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

418) GLX_02670 in NC_016027


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (562),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 114/284 (41%), Positives = 189/284 (67%), Gaps = 8/284 (2%)

Query  5    LPDIMLEPLVRAGLLEDLGRAGDLTTDAVIVDRDTPVRAVFAARQDGVIAGLDMVRLSFA  64
            L  + ++  ++A+L ED+ ++ D +T+A++ +++ +  ++FA ++ GV+AGL + +  F+
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFA-KEAGVLAGLTVFQRVFT  65

Query  65   LMDARIEFQ-PH-VRDGDVITKGTRLATVRGPARGILSGERVGLNFVSHLSGIATATAQL  122
            L DA + FQ PH  +DGD +T G  +  + G+ R++L+ ERV+LNF+ HLSGIA+ TA  
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  VELVRPYKAAITCTRKTMPGLRAIQKYAVRAGGGSNHRFGLDDAILIKDNHIAFAGGITP  182
            VE +   +  +  TRKT P LR ++KYAVR GGG NHRF L DAI++KDNHIA  G++  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AVERARAAAGHLVRIELEVDTLAQLREGLETGGVDVFLLDNMPPDTLREAVRLVDGRAVT  242
            A+ +ARA A  +  +E+EV++LA   E   ++GVD+++LDNM+ + + +A+ L+ GR+  
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  243  EASGGITPQTVTAVAQTGVDLISLGWLTHTVRVMDI---GLDYV  283
            E SG I   T++     ++D +S G LTH+ + +D+   GL Y+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYL  288

419) PCC7418_3121 in NC_019779


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (561),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 184/275 (67%), Gaps = 7/275 (2%)

Query  9    IEPLLQDWLREDIGRGDRATSALIEPTLIPQEAVWIAKQPGIIAGLPIAEKIFRLL-GEI  67
            I+  L+  LRED+   D +T+A+++    ++ ++  AK++G++AGL + +++F L+ +E+
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLF-AKEAGVLAGLTVFQRVFTLFDAEV  71

Query  68   VWH--PQVSEGESCHQQQEILRCRAQPNTLLTGERVALNLVMHLSGIATLTRSYVDKIAD  125
              +   Q  +G+     + +L   +   +LLT ERVALN++ HLSGIA++T +YV+ ++D
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  126  LPTQLVDTRKTTPGLRVLEKYATQLGGAVNHRFGLDDSAMIKENHIQVAGGVKNAIAQVR  185
               ++ DTRKTTP LR++EKYA ++GG+ NHRF L D+ M+K+NHI   G+V++AIAQ R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  186  SQLPYPLTIevetttqaeveaalttevDIIMLDNMSPQLMSEMVQLIRRSGKAIKIEASG  245
            +  P+   +EVE  + A  E A ++ VDIIMLDNMS + + + + LI  +G++ +IE SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI--AGRS-RIECSG  248

Query  246  NITLETIREVAETGVDYISTSAPITQAKWLDLSMK  280
            NI + TI      ++DY+S+++    AK LD+SMK
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

420) Poras_0265 in NC_015501


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (561),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 109/267 (41%), Positives = 181/267 (68%), Gaps = 10/267 (3%)

Query  19   REDAPTGDLSTRYILSESDRAIATLIAKDDGIVSGLEV---AYMVLCRCTPEEEITFTS-  74
            RED  + D ST  I+ + ++A  +L+AK+ G+++GL V    + ++     + E+TF + 
Sbjct  22   REDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF-----DAEVTFQNP  76

Query  75   -EYEDGDEVRKGDILATIEAPYADLLRAERIMLNFLQRMSGIATYTHQCVQCVSGTKTQI  133
             ++ DGD +  GD++  I ++   LL  ER+ LNFLQ++SGIA+ T   V+ +++ + ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  134  LDTRKTAPGHRLTDKMAVRDGGGTNHRASLSDMVMLKDNHIAMAGGILPAVEEVRPNLPI  193
            +DTRKT+P  RL +K AVR GGG NHR +LSD +MLKDNHIA  G++  A+ + R+  P+
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  194  SilievetttleevQEALDAGADIIMLDNMDIETMRRAVVLINGQAKVEASGNMTVERLA  253
              ++EVE  +L   +EA  AG DIIMLDNM +E + +A+ LI G++++E SGN+ +  ++
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  254  AVAAVGVDYISIGALTHSVRAFDISMK  280
               ++++DY+S G+LTHS +++D+SMK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

421) M636_09345 in NC_021848


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (561),  Expect = 2e-38, Method: Compositional matrix adjust.
 Identities = 109/271 (41%), Positives = 179/271 (67%), Gaps = 3/271 (1%)

Query  26   VADTLKEDLGGTLDASQDITASLIPADAMNTATIITREHGVFCGQAWADEVFKQLGGKVT  85
            + DTLK  L   +++ +  T +++  ++    +++++E GV+ G +  + VF  +++ VT
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  86   IE--WHVKDGDKVEPNQTLCTLTGPARDLLTGERNAMNFIQTLSGCATTTAEYAEKIAHT  143
            ++   + KDGD++ + + +  + G+ R LLT ER A+NF+Q LSG A+ TA Y E +++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  144  DCRLLDTRKTIPGLRSALKYAVACGGGFNHRIGVFDAYLIKENHIIACGGITQAITTAKE  203
              +++DTRKT P LR   KYAV  GGG+NHR+ + DA ++K+NHI A G++ +AI+ A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  204  LNP-GKPVEVETESLAELQEAIDAGADIIMLDNFTKEMMRKAVEINAGRAALENSGNITL  262
              P  K VEVE ESLA  +EA  AG DIIMLDN + E + +A+ + AGR+ +E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  263  DTIAEYAETGVDYISVGALTKHLKAMDLSMR  293
             TI+ +   ++DY+S G+LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

422) nadC in NC_006087


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 107/247 (44%), Positives = 163/247 (66%), Gaps = 7/247 (2%)

Query  36   ASARLAAREPGTFAGGEVFAAAMRLTDPGI--QVILAVADGDAFEAGDTLATVSGPAGSV  93
            A   L A+E+G +AG  VF     L D+ +  Q      DGD + +GD +  + G+  S+
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  94   LTAERVALNFAQRMSGIATLTASFVRAVAHTSARIVDTRKTTPGLRAFERHAVRCGGGGN  153
            LT ERVALNF Q++SGIA++TA++V A+++   ++ DTRKTTP LR FE+ AVR GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  154  HRFSLSDAVMAKDNHLAVLTAQSGLSVTAALKKVRRELSHTTHLEVEVDRLDQIEPVLAA  213
            HRF+LSDA+M KDNH+A +      SV  A+ + R   +    +EVEV+ L   E   AA
Sbjct  162  HRFNLSDAIMLKDNHIAAVG-----SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAA  216

Query  214  GVDTIMLDNFTLEQLREGVAIVDGRAIVEASGTVSLSTVRAIAETGVDIISAGALTHSVR  273
            GVD IMLDN +LEQ+ ++++++ GR+ +E SG + ++T+  +   ++D +S+G+LTHS +
Sbjct  217  GVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK  276

Query  274  SLDLGLD  280
            SLD+++ 
Sbjct  277  SLDFSMK  283

423) nadC in NC_004129


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 122/279 (44%), Positives = 200/279 (72%), Gaps = 7/279 (2%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREAAVVAGTAWVDSVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++EA+V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERVVPNQVLFHLEGPARSLLTGERSALNFLQLLSGVATR-ARY  121
             +D+ V+ +   Q  DG+R+ + ++++++ G+ RSLLT ER ALNFLQ LSG+A+  A Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  LADFVADTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIA  181
            +   ++D ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ 
Sbjct  126  VEA-LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  QAISAAHRIAP-GKPvevevesleelkealaaGADIIMLDELSLDDMREAVRLNAGKAKL  240
            +AI+ A+  AP  K VEVEVESL    EA AAG DIIMLD++SL+++ +A+ L AG++++
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  241  EASGGINESTLRPIAETGVDYISIGAMTKDVKALDLSMR  279
            E SG I+ +T+  +   ++DY+S G++T   K+LD+SM+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

424) Desde_0126 in NC_018017


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 118/277 (43%), Positives = 188/277 (68%), Gaps = 9/277 (3%)

Query  3    APFQYQELIERALQEDLGTGDLSS-AIFPRTSKTYAKIYAKQTGIVCGLEITKQVFKAVD  61
            +PFQ ++ +  AL+ED+ + D S+ AIF + +++   ++AK++G++ GL + ++VF   D
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  62   PQLEVSIIK--TDGEKVERGTVVMEIAGAVGSILSAERTALNFLQQLSGVA--TATY-EA  116
            +++         DG+++  G +V+EI G+V S+L+ ER ALNFLQ+LSG+A  TA+Y EA
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  117  VKECHGLSARITDTRKTIPGLRMLQKYAVGMGGGQNHRFGLYDAVMLKDNHIAAAGGIRS  176
            + + +    ++ DTRKT P LR+++KYAV +GGG NHRF L DA+MLKDNHIAA G+++ 
Sbjct  129  LGDDR---IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  177  AVEAARSRIGHMVKIevecesleqveeavavgaevIMLDNMDLETMRKAVEIVQGRAVVE  236
            A+  AR+    +  +EVE ESL   EEA A G ++IMLDNM LE + +A+ ++ GR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  237  ASGGIKKDDLRAVAETGVDVISMGAITHSVKAMDFSL  273
             SG I    +      ++D +S G++THS K++DFS+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

425) amad1_15015 in NC_019393


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 192/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

426) I607_14315 in NC_021710


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 192/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

427) I876_14610 in NC_021717


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 192/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

428) I634_14555 in NC_021712


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 192/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

429) I636_14430 in NC_021714


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 192/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

430) I635_14985 in NC_021713


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  152 bits (559),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 192/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPvevevenvaeleQALSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VEVEVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

431) TCCBUS3UF1_12200 in NC_017278


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (558),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 129/269 (48%), Positives = 192/269 (72%), Gaps = 2/269 (0%)

Query  4    DETLRAWLQEDLGHGDLTSLLTVPEGLEGEAVILAKERGVLAGLPVAARVFALAEARLAF  63
            D+TL+A L+ED+   D ++     +  ++   ++AKE GVLAGL V  RVF+L +A ++F
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  64   LPQKE--EGDPIAPGEEVARIRGPLRGILAGERLALNLLQRLSGIATLTRAYVEALAGTR  121
                +  +GD +++G+ V  I G++R++L+ ER+ALN+LQ+LSGIA++T AYVEAL++ R
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  122  TQVLDTRKTTPGLRALEKYAVRVGGGRNHRFGLFDGILLKENHLraaggvraavrraKEG  181
             +V+DTRKTTP LR +EKYAVRVGGG NHRF L D+I+LK+NH+ A G+V+ A+ +A+  
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  182  APHYlqvevevtnleeleealaagadlillDNFPPEAMREAVRRVGGRVPLEASGNMTLE  241
            AP    VEVEV +L   EEA AAG D+I+LDN + E + +A+  ++GR  +E SGN+ + 
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  242  RARAAAEAGVDYVSVGALTHSAKALDLSL  270
                    ++DYVS G+LTHSAK+LD+S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

432) Nos7524_3692 in NC_019684


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (558),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 121/281 (44%), Positives = 181/281 (65%), Gaps = 7/281 (2%)

Query  7    LPPWLVIDPLLSSWLLEDVGRGDRTTNSLLATDAITGTATWIVKapgiiaglpiaaRVFQ  66
            L P  + D L ++ L EDV   D +TN+++  ++  +  + + K +G++AGL +  RVF 
Sbjct  8    LTPFQIDDTLKAA-LREDVHSEDYSTNAIFDHHG-QAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  67   LLNEKVNFVATA--NEGSFCEAGQVVAEIDGSLDALLMGERVALNLAMRLSGIATLTNKY  124
            L++  V F      ++G    +G++V EI GS+ +LL  ERVALN+  +LSGIA++T  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  125  VDQIADLSAQLVDTRKTTPGLRLLEKYATAVGGAINHRMGLDDAVMIKDNHIAAAGGVGE  184
            V+ ++D   ++ DTRKTTP LRL+EKYA  VGG+ NHR  L DA+M+KDNHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  185  AITRIRAKIPYPLTIEVEAESLDQVQEALQYKADIIMLDNMPLDLMREAVHLIRQQDKRV  244
            AI++ RA  P+   +EVE ESL   +EA     DIIMLDNM+L+ + +A+ LI     R 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  245  KIEASGNVTLATIRAVAETGVDYISSSAPITQSGWLDLSMK  285
            +IE SGN+ ++TI      ++DY+SS++    +  LD+SMK
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

433) Dvul_1353 in NC_008751


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (558),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 111/265 (42%), Positives = 166/265 (63%), Gaps = 11/265 (4%)

Query  29   DGPDLTSDAVFSPEDRLEAVVVAKQHTLVAGLPIAPIILDRCPEVHPYTLEMPVRDGDRL  88
            ++ D +++A+F  +++    + AK+  ++AGL +   ++        +      +DGDRL
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRL  85

Query  89   APGDTALRVAGSARHILKAERVILNFMTHLSGIANLTHDYVTALEGTHTRLLDTRKTLPG  148
            ++GD  L + GS R +L  ERV LNF+ HLSGIA++T  YV AL + + +++DTRKT P 
Sbjct  86   TSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPN  145

Query  149  LRHVEKYAVLVGGGLNHRIDLAEMLMLKDNHIDAAGSITAAVTRLRTAYAP-CPPIEVEC  207
            LR  EKYAV VGGG NHR++L++ +MLKDNHI A GS+  A+++ R AYAP    +EVE 
Sbjct  146  LRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR-AYAPFVKMVEVEV  204

Query  208  RTMEEVAEAVACHVDRIMLDNMTPEAMRAALGIIPRTIETETSGGVTLETI---RSLALV  264
             ++    EA A  VD IMLDNM+ E +  A+ +I+     E SG + + TI   R+LA+ 
Sbjct  205  ESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAI-  263

Query  265  GDRGPDFISVGRLTHSAPAADFSMR  289
                 D++S G LTHSA + DFSM+
Sbjct  264  -----DYVSSGSLTHSAKSLDFSMK  283

434) nadC in NC_002937


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (558),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 111/265 (42%), Positives = 166/265 (63%), Gaps = 11/265 (4%)

Query  29   DGPDLTSDAVFSPEDRLEAVVVAKQHTLVAGLPIAPIILDRCPEVHPYTLEMPVRDGDRL  88
            ++ D +++A+F  +++    + AK+  ++AGL +   ++        +      +DGDRL
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRL  85

Query  89   APGDTALRVAGSARHILKAERVILNFMTHLSGIANLTHDYVTALEGTHTRLLDTRKTLPG  148
            ++GD  L + GS R +L  ERV LNF+ HLSGIA++T  YV AL + + +++DTRKT P 
Sbjct  86   TSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPN  145

Query  149  LRHVEKYAVLVGGGLNHRIDLAEMLMLKDNHIDAAGSITAAVTRLRTAYAP-CPPIEVEC  207
            LR  EKYAV VGGG NHR++L++ +MLKDNHI A GS+  A+++ R AYAP    +EVE 
Sbjct  146  LRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR-AYAPFVKMVEVEV  204

Query  208  RTMEEVAEAVACHVDRIMLDNMTPEAMRAALGIIPRTIETETSGGVTLETI---RSLALV  264
             ++    EA A  VD IMLDNM+ E +  A+ +I+     E SG + + TI   R+LA+ 
Sbjct  205  ESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAI-  263

Query  265  GDRGPDFISVGRLTHSAPAADFSMR  289
                 D++S G LTHSA + DFSM+
Sbjct  264  -----DYVSSGSLTHSAKSLDFSMK  283

435) Deval_1496 in NC_017310


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (558),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 111/265 (42%), Positives = 166/265 (63%), Gaps = 11/265 (4%)

Query  29   DGPDLTSDAVFSPEDRLEAVVVAKQHTLVAGLPIAPIILDRCPEVHPYTLEMPVRDGDRL  88
            ++ D +++A+F  +++    + AK+  ++AGL +   ++        +      +DGDRL
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRL  85

Query  89   APGDTALRVAGSARHILKAERVILNFMTHLSGIANLTHDYVTALEGTHTRLLDTRKTLPG  148
            ++GD  L + GS R +L  ERV LNF+ HLSGIA++T  YV AL + + +++DTRKT P 
Sbjct  86   TSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPN  145

Query  149  LRHVEKYAVLVGGGLNHRIDLAEMLMLKDNHIDAAGSITAAVTRLRTAYAP-CPPIEVEC  207
            LR  EKYAV VGGG NHR++L++ +MLKDNHI A GS+  A+++ R AYAP    +EVE 
Sbjct  146  LRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR-AYAPFVKMVEVEV  204

Query  208  RTMEEVAEAVACHVDRIMLDNMTPEAMRAALGIIPRTIETETSGGVTLETI---RSLALV  264
             ++    EA A  VD IMLDNM+ E +  A+ +I+     E SG + + TI   R+LA+ 
Sbjct  205  ESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAI-  263

Query  265  GDRGPDFISVGRLTHSAPAADFSMR  289
                 D++S G LTHSA + DFSM+
Sbjct  264  -----DYVSSGSLTHSAKSLDFSMK  283

436) Ftrac_2356 in NC_014759


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (558),  Expect = 3e-38, Method: Compositional matrix adjust.
 Identities = 117/285 (42%), Positives = 180/285 (64%), Gaps = 10/285 (3%)

Query  6    LTKENIQKFIQSALAEDIREGDHSSLASIPAGTQNTAQLIIKGDGILAGMEMAEHIFKAV  65
            LT  +I+  +++AL ED++  D S+ A +    Q    L+ K  G+LAG+ + +++F   
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  66   DEKLEID----FFKKDGDKVTSGEIGLKVHGSAVSILSAERLVLNCLQRMSGIATYTHNL  121
            D  + ++    F  KDGD++TSG++ L + GS  S+L+ ER+ LN LQ++SGIA+ T   
Sbjct  68   DAEVTFQNPHQF--KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  NELIKHTSTKLLDTRKTTPNFRIAEKWAVAIGGGQNHRFGLFDMVMLKDNHNDFAGGITK  181
             E + +   K++DTRKTTPN+R+ EK AV +GGG NHRF L D +MLKDNH    G++ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  182  AVESTQEYLKQNNLDLRIEVETRNLDEVKEALAVGGVDVIMLDNMDIPEMKQAVEIINGK  241
            A+  ++ Y     +   +EVE  +L    EA A +GVD+IMLDNM + ++ QA+ +I G+
Sbjct  186  AIAQARAY---APFVKMVEVEVESLAAAEEA-AAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  242  CETEASGGITEDTIKAIAETGVDYISVGALTHSYKSLDMSLKAVS  286
               E SG I   TI  +   ++DY+S G+LTHS KSLD S+K+++
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

437) nadC in NC_021237


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (557),  Expect = 4e-38, Method: Compositional matrix adjust.
 Identities = 122/279 (44%), Positives = 200/279 (72%), Gaps = 7/279 (2%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREAAVVAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++EA+V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERVVPNQVLFHLEGPARSLLTGERSALNFLQLLSGVATR-ARY  121
             +D+ V+ +   Q  DG+R+ + ++++++ G+ RSLLT ER ALNFLQ LSG+A+  A Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  LADFVADTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIA  181
            +   ++D ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ 
Sbjct  126  VEA-LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  QAISAAHRIAP-GKPvevevesleelkealaaGADIIMLDELSLDDMREAVRLNAGKAKL  240
            +AI+ A+  AP  K VEVEVESL    EA AAG DIIMLD++SL+++ +A+ L AG++++
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  241  EASGGINESTLRPIAETGVDYISIGAMTKDVKALDLSMR  279
            E SG I+ +T+  +   ++DY+S G++T   K+LD+SM+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

438) nadC in NC_010475


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (557),  Expect = 4e-38, Method: Compositional matrix adjust.
 Identities = 123/286 (44%), Positives = 185/286 (65%), Gaps = 11/286 (3%)

Query  2    ATLPPWLIVDPLLQQWLQEDLGRGDRTTQSLFANTQAPIGQAKLIL--KADGQVAGLPLV  59
            + L P  I D L +  L+ED+   D +T+++F +     GQAK+ L  K  G +AGL + 
Sbjct  6    TDLTPFQIDDTL-KAALREDVHSEDYSTNAIFDHH----GQAKVSLFAKEAGVLAGLTVF  60

Query  60   ERVFQLLDPQ-NFKFETALSEGSSGQPKNLIATMTAPLDILLMGERVALNILMRLSGIAT  118
            +RVF L+D++  F+    + +G    + +L+  + +++  LL  ERVALN+L +LSGIA+
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  119  MTAQYVEKIADLPTQLVDTRKTTPGLRLLEKYAVQVGGGQNHRFGLDDAVMIKDNHiqaa  178
            MTA YVE ++D   ++ DTRKTTP LRL+EKYAV+VGGG NHRF L DA+M+KDNHI A 
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  179  ggisqaiaLVRQNMPYPLAIEVEAETPEQAFEAVTAGADILMLDNMSVAMMADLIPPLRA  238
            G++ +AIA  R   P+   +EVE E+   A EA +AG DI+MLDNMS+  + + I  + +
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  239  KNPRLKLEASGNITLETLREAALTGIDYISTSATITRAPWLDISMK  284
            ++   ++E SGNI + T+      +IDY+S+++    A  LD+SMK
Sbjct  241  RS---RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

439) I633_15505 in NC_021716


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (557),  Expect = 4e-38, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 191/272 (71%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELDAAHDITANLIDESVNAKASIITREPCVVCGIAWATQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK S++++E+ V+ G++   + F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDSVAADTLLVSLEGSARAILTAERTALNFLQTLSATATVTAFYAKYLEG  129
            ++    + KDGD ++++ L++ + GS R++LT ER ALNFLQ LS+ A++TA Y   L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  STTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAISRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KAI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  SMMP-GKPveaevenvaeleqaLSAGADIVMLDNFTNEQIQEAVALNKGQCKLEVSGNIT  248
            +  P  K VE EVE++A  E+A +AG DI+MLDN + EQI++A++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

440) TTC0621 in NC_005835


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (556),  Expect = 5e-38, Method: Compositional matrix adjust.
 Identities = 121/282 (43%), Positives = 198/282 (71%), Gaps = 4/282 (1%)

Query  3    GVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDIEGEAVILAKEGGVLAGLWVAE  62
            ++++  L    ++++L+A LRED+   D ++  +  ++ ++   ++AKE+GVLAGL V +
Sbjct  2    SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  63   RVFALADPRTAF--APLVAEGARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATL  120
            RVF+L D+  +F  +    +G R++ G  V  + G++R++L+ ER+ALN+LQ+LSGIA++
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  121  TRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRNHRYGLFDGILIKENHvraag  180
            T AYVEAL++ + +++DTRKTTP LR +EKYAVRVGGG NHR+ L D+I++K+NH+ A G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  181  gvgeavrrakaraPHYLKvevevrdl-aeleealeagadlilldNFPLEALREAVRRVGG  239
            +V  A+ +A+A AP ++K+     +  A  EEA  AG D+I+LDN +LE + +A+  ++G
Sbjct  182  SVQKAIAQARAYAP-FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  240  RVPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSL  281
            R  +E SGN+ +         ++DYVS G+LTHSAK+LD+S+
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

441) nadC in NC_000918


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (556),  Expect = 5e-38, Method: Compositional matrix adjust.
 Identities = 109/261 (42%), Positives = 181/261 (70%), Gaps = 6/261 (2%)

Query  17   DIGTGDITTEGIY-RGEKAKAVIKTKEEGVLAGAPFVEMVFEILGGVSVEFKK----REG  71
            D+ + D +T++I+ +  +AK  + +KE GVLAG    + VF ++++  V F++    ++G
Sbjct  24   DVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA-EVTFQNPHQFKDG  82

Query  72   EVFEKGEILAILEGDAKSLLIGERLSLNILQRLSGIATTARKFVEKLKGTNVKILDTRKT  131
            + +  G+++  + G  +SLL  ER++LN+LQ+LSGIA+ +  +VE L +  +K++DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  132  TPGFRYFEKYAVRIGGGTNHRFGLYDMVLIKDNHKRVAGSIKEAVKRVRERISPVYKIev  191
            TP +R FEKYAVR+GGG NHRF L D +++KDNH    GS++ A+ + R   + V  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  192  evenleeveeALSAGVDVIMLDNFTPEEVKRAVEIIKGRALVEVSGNITLDNVLDYAVEG  251
            EVE+L   EEA +AGVD+IMLDN + E++ +A+ +I GR+ +E SGNI +  +  +   +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  252  VDFISSGAIVHSSRWLDISLK  272
            +D++SSG++ HS++ LD+S+K
Sbjct  263  IDYVSSGSLTHSAKSLDFSMK  283

442) Tcur_4484 in NC_013510


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (556),  Expect = 5e-38, Method: Compositional matrix adjust.
 Identities = 115/281 (41%), Positives = 188/281 (67%), Gaps = 8/281 (2%)

Query  12   LIHAGLDPREVQDLARRALAEDGEV-DVTSEPIFSPEQTARGVFTARQDgvvagipvaav  70
            +I ++L P +++D  + AL ED +  D ++++IF  +  A+  + A++ GV+AG+ V   
Sbjct  3    IISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  71   vCDLLG----LTTVPHVQDGERVGAGQALMTVSGSTRGLLRAERVALNLLTHLSGIATLT  126
            V  L++    +    + +DG+R+ +G+ ++ + GS R+LL  ERVALN+L HLSGIA++T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  127  RRWVDAVAGTGVKIRDTRKTLPGLRALQKYAVRCGGGVNHRMGLHDAALIKDNHVAAAGS  186
               V+A+++  +K+ DTRKT P LR ++KYAVR GGG NHR  L DA ++KDNH+AA GS
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  187  VTKAFQAVRAMYPSL--HIQVECDTLEQVAEALEAGARSILLDNMSTEQMREAVRLVAGR  244
            V KA+   RA Y+++   ++VE ++L    EA  AG   I+LDNMS EQ+ +A+ L+AGR
Sbjct  183  VQKAIAQARA-YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  245  AELEASGGLTLDRARDAAATGVDYLAVGALTHSAPSFDIGL  285
            + +E SG + +       + ++DY++ G+LTHSA S+D+++
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

443) Xaut_1181 in NC_009720


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (555),  Expect = 5e-38, Method: Compositional matrix adjust.
 Identities = 112/276 (41%), Positives = 187/276 (68%), Gaps = 3/276 (1%)

Query  6    LPELMVEPIVRAALLEDLGRAGDITTDAVVPPGHESRLVLAARQPGVVAGLDCARLAFRL  65
            L  + ++  ++AAL ED+ ++ D +T+A+     ++++ L A+++GV+AGL   +  F L
Sbjct  8    LTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  66   LDGAVRF--TPRVTDGAAVEPGTVLAQVEGSSRALLTGERTGLNLACRLSgiatataglv  123
            +D+ V F    +  DG  + +G ++ ++ GS R+LLT ER +LN+  +LSGIA+ TA+ V
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  124  aaiagHKAQIVCTRKTTPGLRSLEKYAVRAGGGANHRFGLDDAVLIKDNHVAIAGSVREA  183
             A+++++ ++  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNH+A  GSV+ A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  184  MSRVRARAGHMVKVEVEVDTLAQLEELLTIGADAVLLDNMTPETLTEAVRMVGGRMLTEA  243
            +++ RA A  +  VEVEV++LA  EE  + G D ++LDNM+ E + +A+ +++GR   E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  244  SGRVNRDTAPAIAAAGVDLISVGWLTHSAPILDIGL  279
            SG ++  T + + + ++D +S G LTHSA  LD+++
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

444) Dester_1111 in NC_015185


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (555),  Expect = 6e-38, Method: Compositional matrix adjust.
 Identities = 104/248 (42%), Positives = 169/248 (69%), Gaps = 7/248 (2%)

Query  35   RAEIIAKEDFILCGAPFFEEVFRLYDNNVKFEWKK--KEGESVFPGEIVGIVLGNIKTLL  92
            +  ++AKE  +L G   F+ VF L+D +V F+     K+G+ + +G++V  ++G++++LL
Sbjct  43   KVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL  102

Query  93   TCERTALNILQRLSGIATETKKYVDVLKGSKVKLLDTRKTTPGLRYLEKYATRIGGAFNH  152
            TCER ALN+LQ+LSGIA+ T  YV+ L + ++K++DTRKTTP LR +EKYA R+GG++NH
Sbjct  103  TCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNH  162

Query  153  RLGLYDAVMIKDNHIKPFGSVITAVKSISSSIPVTTKIeveveneeqlqevmevIELVDI  212
            R+ L DA+M+KDNHI + GSV  A+    +  P    +EVEVE+    +E       VDI
Sbjct  163  RFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG--VDI  220

Query  213  VMLDNWNVEKVEEATLKLKKQKPTIKVEVSGNITIEKLKRLKYKSIDFVSTSKIITGAKW  272
            +MLDN ++E++E+A + L   ++  ++E SGNI +  + R++  +ID+VS++ +  +AK 
Sbjct  221  IMLDNMSLEQIEQA-ITLIAGRS--RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKS  277

Query  273  VDISMEVL  280
            +D+SM  L
Sbjct  278  LDFSMKGL  285

445) nadC in NC_004113


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (555),  Expect = 6e-38, Method: Compositional matrix adjust.
 Identities = 118/286 (42%), Positives = 184/286 (65%), Gaps = 14/286 (4%)

Query  9    LPPWSVLDPLLDQWLQEDIGRGDRTTQALHLQDRQGKAHIRL--KSQGVIAGLPIVERVF  66
            L P  + D  L   L+ED+   D +T+A+   D++G+A + L  K  GV+AGL + +RVF
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIF--DHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  67   QRLTTAVVFT----YEQAEGAICEEPTIVARIAAPletlllgerlalNCLMRLSGIATLT  122
              + + V F     + +++     +  +V  I +++ +LL  ER+ALN L +LSGIA++T
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGD--LVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  123  HTYVQAIADLPTQLVDTRKTTPGLRLLEKYAVAVGGGVNHRFGLDDAILIKDNHIVAAGG  182
             +YV+A++D   ++ DTRKTTP LRL+EKYAV VGGG NHRF L DAI++KDNHI A G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  183  ITAAVEKVRQASPFPLAIEVETETLEQVREALFLGVDVIMLDNMPIPEMTQAVAMIRAEA  242
            +  A+ + R  +PF   +EVE E+L    EA   GVD+IMLDNM++ ++ QA+++I   A
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---A  239

Query  243  PHIKIEASGNITLETLRPVALTGVDYISTSAMITRSPWLDFSLTIL  288
             + +IE SGNI + T+      ++DY+S++++   +  LDFS+  L
Sbjct  240  GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

446) nadC in NC_014033


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (555),  Expect = 6e-38, Method: Compositional matrix adjust.
 Identities = 107/266 (41%), Positives = 167/266 (63%), Gaps = 6/266 (2%)

Query  18   EDIGDGDHTTLCCIPEDAMGKSHLLIKEDGILAGVEIAKEVFHRFDP--TMQVEVLMQDG  75
            ED+   D +T   + +++ +K  L+ KE G+LAG+ + + VF  FD+  T Q     +DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  76   TRVKKGDIAMIVSGKIRSLLQTERLMLNIMQRMSGIATMTDKYVKRLEGTSTRVLDTRKT  135
             R+  GD+ + + G +RSLL  ER+ LN++Q++SGIA+MT  YV  L +   +V+DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  136  TPGMRMLEKQAVKIGGGCNHRIGLFDMILLKDNHVDFAGGITNAIDRCHKYLDEKGLNLK  195
            TP +R++EK AV++GGG NHR+ L D I+LKDNH+   G++ +AI + + Y     +   
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY---APFVKM  199

Query  196  IEIEVRSFDELQQVLDHGGVDRIMLDNFSVPDTKKAVDIINHRYETESSGGITFDTIRDY  255
            +E+EV S+    +    +GVD IMLDN S+ +  +A+ +I  R   E SG I   TI  +
Sbjct  200  VEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  256  AEQGVDFISVGALTHSVKGLDMSFKA  281
               ++D++S G+LTHS K+LD S K+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMKG  284

447) Slin_5167 in NC_013730


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  151 bits (555),  Expect = 6e-38, Method: Compositional matrix adjust.
 Identities = 110/269 (41%), Positives = 177/269 (66%), Gaps = 6/269 (2%)

Query  10   ALAEDVGDGDHTSLSTIPADAQKRARLLVKETGILAGVEVAKAVFA--EVDPTFVVDVLL  67
            AL EDV   D ++ + +  ++Q +  L+ KE+G+LAG+ V + VF+  + + TF     +
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  68   HDGASISPGDVVLTVGGNARNILTAERLVLNCMQRMSGIATHTRELVNLLEGTRAKLLDT  127
             DG  +++GD+VL + G+ R++LT ER+ LN +Q++SGIA+ T   V+ L + R K++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  128  RKTTPNFRICEKMATKIGGAVNHRFGLYDMILIKDNHVDYAGSIEAAITKAVSYLSETGR  187
            RKTTPN+R+ EK A ++GG+ NHRF L D I++KDNH+   GS++ AI++A +Y +   +
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY-APFVK  198

Query  188  KLRIEVETRNRAEVEEVLRVGQVDVILLDNFAPDGIRDMVRLINGRFVTEASGGIDETNL  247
             + +EVE+   AE       + VD+I+LDN + + I + + LI GR   E SG ID T +
Sbjct  199  MVEVEVESLAAAEEAA---AAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  248  RAYAETGVDYISSGALTHQIKSLDLSLKA  276
              +   ++DY+SSG+LTH  KSLD+S+K+
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

448) Osc7112_3279 in NC_019729


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (552),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 121/285 (43%), Positives = 186/285 (66%), Gaps = 7/285 (2%)

Query  1    MTAILPPWIVLDSLLHNWLLEDIGRGDRTTSALFPANSIQGTAKWIVKEAGVIAGLPIAD  60
            +++ L P  + D  L   L ED+   D +T+A+F  ++ Q+    + KEAGV+AGL + +
Sbjct  4    ISTDLTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHG-QAKVSLFAKEAGVLAGLTVFQ  61

Query  61   RTFKLLDSSLSFI--PQVPEGKLCDKGEVIAEISGNFDALLTGERVALNLAMRLSGIATL  118
            R F L+D+ ++F    Q  +G     G+++ EI G+  +LLT ERVALN+  +LSGIA++
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  119  TQKYVDKIADLPVQLVDTRKTTPGLRLLEKYATQIGGACNHRMGLDDAVMVKDNHiaaag  178
            T  YV+ ++D  +++ DTRKTTP LRL+EKYA ++GG+ NHR  L DA+M+KDNHIAA G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  179  giaeaialiRNSIPYPLTIevetetlaevetalQHKADIIMLDNMSFDLMRQAVAIIRQK  238
            ++  AIA  R   P+   +EVE E+LA  E A     DIIMLDNMS++ + QA+++I   
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---  238

Query  239  SDRVKIEASGNVTLETIRSVAETGVDYISTSAPITRSTWLDLSMK  283
            ++R +IE SGN+ + TI      ++DY+S+++    +  LD+SMK
Sbjct  239  AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

449) nadC in NC_007498


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (551),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 116/272 (43%), Positives = 186/272 (69%), Gaps = 2/272 (0%)

Query  2    FEIDRIIRTALQEDIGLGDIttqatiatgttaraELVAKQDFVLAGIDVACQVFHVLDPS  61
            F+ID  +++AL+ED+   D +T+A +     A+  L AK+  VLAG+ V  +VF ++D+ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  62   IAFEKLRE--DGVHVQRGDVLAWIKGEAATLLQGERVALNLMQRMSGVATHAAAFVKELE  119
            ++F++ ++  DG ++  GD++  I G   +LL  ERVALN++Q++SG+A+ +AA+V  L 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  120  GTGAAVVDTRKTTPGLRVLEKYAVRVGGGRNHRTSLYDGVLIKENHvaaaggiavavara  179
            +    V DTRKTTP LR++EKYAVRVGGG NHR +L D++++K+NH+AA G++  A+A+A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  180  rETAPHTLRIEVETRNLEEVKEALVAGADVIMLDNMDLETLAEAVALVDGNAVTEASGGV  239
            R  AP    +EVE  +L    EA  AG D+IMLDNM LE + +A++L+ G +  E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  240  TLETVRGIAETGVDLISVGALTHSSPAVDISM  271
             + T+  +   ++D +S G+LTHS+ ++D+SM
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

450) nadC in NC_014147


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (551),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 115/278 (42%), Positives = 191/278 (69%), Gaps = 12/278 (4%)

Query  16   TVQAALLEDLGRRGDVTSAAVIAKNSTANLAIVSRDTGILAGMDLARLAFECIDKTINF-  74
            T++AAL ED+ +  D ++ A++  ++ A++++ ++++G+LAG+ + +  F  +D  + F 
Sbjct  16   TLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  75   SPNA-SDGDTIKSGQVLAYVSGNTQALLQAERTALNFLTHLSGIASMTAKAVAQISHTQA  133
            +P+   DGD + SG+++  + G+ ++LL  ER ALNFL HLSGIASMTA  V  +++ + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  134  KITCTRKTTPLLRNLQKYAVRAGGGCNHRMGLDDAILIKDNHLIYSGTLKQTIANAKAAA  193
            K+  TRKTTP LR ++KYAVR GGG NHR  L DAI++KDNH+   G+++++IA+A+A A
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  194  GHLIPIEVEVDTIAQLEEALEAGADFVLLDNMDNDTLKHAVSLCQGRAKTEASGGI---T  250
              +  +EVEV+++A  EEA  AG D+++LDNM  + + +A++L  GR++ E SG I   T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  251  FERLKTVADCGVDYIALGYLTHSVINHDI---GLDFLD  285
            + R++ +A   +DY++ G LTHS  + D+   GL +LD
Sbjct  255  ISRFRGLA---IDYVSSGSLTHSAKSLDFSMKGLTYLD  289

451) nadC in NC_017911


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (551),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 115/278 (42%), Positives = 198/278 (72%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREAAVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++EA+V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERVSPNQALFHLEGPARSLLSGERCALNFLQLLSGVATRAQFL  122
             +D+ V+ +   Q  DG+R+++ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADFVASTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIAQ  182
             + ++  ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AITAAHKIAP-GKPVeievenleelrealSAGADIIMLDELSLDDMREAVRLNAGKAKLE  241
            AI+ A+  AP  K VE+EVE+L    EA +AG DIIMLD++SL+++ +A+ L AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINETTLLPIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG I+ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

452) H045_00795 in NC_020209


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (551),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 112/273 (42%), Positives = 193/273 (71%), Gaps = 6/273 (2%)

Query  12   EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRDAAVISGTAWVDAVFRQLDPRV  70
            +I+  ++ AL ED+ S D +++ I  ++  AK ++++++A+V++G +  + VF  +D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   AVH--WQVADGERVSPNQVLFHLEGPARSLLSGERCALNFLQLLSGVATR-AQYLADFVA  127
            + +   Q  DG+R+++ ++++++ G+ RSLL+ ER ALNFLQ LSG+A+  A Y+   ++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA-LG  130

Query  128  STQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRMGLYDAFLIKENHIAACGGISQAVAAA  187
              ++K++DTRKT P LRL +KYAV  GG  NHR  L DA+++K+NHIAA G++ +A+A A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  188  HKIAP-GKPVeievesleelrealDAGADIIMLDELSLDDMREAVRLNGGKARLEASGGI  246
            +  AP  K VE+EVESL    EA  AG DIIMLD++SL+++ +A+ L +G++R+E SG I
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  247  NESTLLPIAETGVDYISIGAMTKDVKAVDLSMR  279
            + +T+  +   ++DY+S G++T   K++D+SM+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

453) nadC in NC_008599


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (552),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 110/273 (41%), Positives = 187/273 (69%), Gaps = 7/273 (2%)

Query  5    INELINLGFKEDLSSSGDITSLAIFNDEKDS-FYLICKSDGVLCGIDIFKKVFKFIDENI  63
            I++ ++ +++ED+ S  D ++ AIF+++ ++   L+ K  GVL G+ +F++VF ++D ++
Sbjct  13   IDDTLKAALREDVHSE-DYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  64   SVE--LYFKDGDAIKYADMVAKVSGSVINILQAERVAINFISYLSGIATKTSIFVKE-SK  120
            + +    FKDGD +  +D+V  + GSV ++L  ERVA+NF+  LSGIA+ T+ +V   + 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  121  GNVKILDTRKTLPAYRMLAKYAVKCGGGENHRIGLYDMILIKDNHIDAAGGITNAVTKIR  180
            + +K++DTRKT P  R++ KYAV+ GGG NHR+ L D I++KDNHI A G++ +A+++ R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  181  QKYGNKFK-IEVETRSLNEVKEALNLGIDMIMFDNMSLEMMREAVKIVSQKVFIEASGNM  239
              Y+   K +EVE  SL    EA   G+D+IM+DNMSLE + +A+ +++ +  IE SGN+
Sbjct  192  A-YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  240  SLDKIKKLADCGVDAISFGELTHSVKAFDFSLK  272
             +  I ++ + ++D +S G LTHS K++DFS+K
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

454) Q7C_281 in NC_017856


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (554),  Expect = 7e-38, Method: Compositional matrix adjust.
 Identities = 121/272 (45%), Positives = 179/272 (66%), Gaps = 6/272 (2%)

Query  12   IASQVKLALLEDIGQGDL-TAALIPNDKRAVAKLIAREPGVLAGTDWVTQAFQQCSPEIT  70
            I   +K AL ED+   D  T A++ ++ +A   L+A+E+GVLAG     + F    +E+T
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   L---HWFQHDGSHLQQNDLICEIRGNARAMLSAERTALNFLQTLSGTATLTRRYIEALQG  127
            +   H F+ DG +L   DL+ EI G+ R++L+ ER ALNFLQ LSG A++T  Y+EAL +
Sbjct  73   FQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  128  LNTTLLDTRKTIPGLRLAQKYAVRCGGGSNHRFGLFDAILIKENHIQAAGNIQAAVKQAR  187
                ++DTRKT P LRL +KYAVR GGG NHRF L DAI++K+NHI A G++Q A+ QAR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  188  NVNSNVT-IelevenleelQQGLHAGVDIILLDNFSIETLSTAVELTAGQTLLEASGGIT  246
               + V  +E+EVE+L   +++  AGVDII+LDN S+E +  A+ L AG++ +E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  247  IENIRQIAETGVNRISVGSLTKDVCALDLSMR  278
            +  I ++   +++ +S GSLT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

455) nadC in NC_018000


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (554),  Expect = 7e-38, Method: Compositional matrix adjust.
 Identities = 119/294 (41%), Positives = 193/294 (66%), Gaps = 17/294 (5%)

Query  5    LRPELPALLVEEQVKTALLEDLGRAGDITTLATIGPDMTATANMSAREAGVIAGMELART  64
            +  +L ++ +++ +K+AL ED+ ++ D +T A ++ +  A  ++ A+EAGV+AG+ + + 
Sbjct  4    ISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  65   AFRLVDPSIRFEA--LVADGDRVAPGITVARISGRARGVLSAERVALNFLMHLSGISSYT  122
             F L D+ + F+      DGDR+++G  V  I G  R++L+ ERVALNFL HLSGI+S T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  123  AKFADEIGHTAAKVCCTRKTIPGLRALEKYAVRLSGGSNHRYGLDDAVLIKDNHiavsgg  182
            A + + +G+   KV  TRKT P LR +EKYAVR++GG NHR+ L DA+++KDNHIA  G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  183  vagairaaraYCGHLVKVEVEVDGLAQMREALTAAPDVILLDNMGPELLREAVAVNAEHW  242
            V  AI  ARAY   +  VEVEV++LA   EA +A+ D+I+LDNM+ E + +A+++ A   
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG--  240

Query  243  GLSAASYAGDLRRTRLEASGNVKIETIRALAESGVDYISTSKITMAAPTLDIGL  296
                        R+R+E SGN+ + TI  +   ++DY+S++ +T +A +LD+++
Sbjct  241  ------------RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

456) B841_01340 in NC_021915


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (553),  Expect = 8e-38, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 180/278 (65%), Gaps = 9/278 (3%)

Query  5    IRGIVAAALAEDAPHGDLTSEALVPVDAQLSASLVAREPGRFSGGEVFATVFELVDASVT  64
            I + + AAL ED    D +++A+   ++Q   SL A+E+G ++G  VF  VF L DA VT
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  65   VELA--VTDGTAFQPGDVLATVNGPARAVLRAERIALNLVQRMSGVATLTARYVAEVKGT  122
             + +    DG  + +GD++  + G+ R++L  ER+ALN++Q++SG+A++TA YV  + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  123  AARIVDTRKTTPGLRVLERQAVRDGGGHNHRFFLSDAVMAKDNHLAALSTAGVSLADALR  182
              ++ DTRKTTP LR++E+ AVR GGG NHRF LSDA+M KDNH+AA++    S+  A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG----SVQKAIA  188

Query  183  QARARISHTTHLEVEVDRLDQLEEVLAVEPGVVNSVMLDNFELADLRRGVELVDGRLIVE  242
            QARA  +    +EVEV+ L   EE  A     V+ +MLDN  L ++ +++ L+ GR  +E
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAG---VDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  243  ASGGVTLDTVGDIARTGVDVISVGALTHSVRSLDLGLD  280
             SG + + T++ +   ++D +S G+LTHS +SLD+++ 
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

457) AMBLS11_13955 in NC_018692


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  150 bits (553),  Expect = 9e-38, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 190/272 (70%), Gaps = 3/272 (1%)

Query  12   QVSNALIEDLGGELNAANDITANLIDESVNAKATIITREPCVVCGIAWANQAFALIDESV  71
            Q+ ++L   L  ++++ +  T  ++D+  +AK +++++E+ V+ G++  ++ F+L+D  V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   SL--TWHVKDGDKVDANTVLVSLEGSARAILTAERTALNFLQTLSatatttaFYAKFLDG  129
            ++    + KDGD++ +  +++ + GS R++LT ER ALNFLQ LS+ A+ TA Y   L++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  SNTKILDTRKTLPGLRYAQKYAVRCGGGQNHRVGLFDAFLIKENHIFSCGNIEKAVSRAK  189
               K++DTRKT P LR  +KYAVR GGG NHR  L DA+++K+NHI + G+++KA+++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  AMMP-GKPveveveDLTELEQALRAGADIVMLDNFSNEQIQQAVALNKGQCKLEVSGNIT  248
            A  P  K VEVEVE L+  E+A  AG DI+MLDN S EQI+QA++L  G+ ++E SGNI 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  DERLASLAKLGVDYISSGALTKHVQAIDLSLR  280
               ++ +  L++DY+SSG+LT   +++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

458) nadC in NC_006582


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (550),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 117/276 (43%), Positives = 191/276 (70%), Gaps = 5/276 (1%)

Query  1    MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVE-RAEAVIVAKGEGIFAGTQVVNQLYALL  59
            + P+++D+ L++ L ED+   D +++A+F  + +A   + AK  G++AG  V +++++L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   DSDI---EVELFVRDGEQVKRGQQLARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAV  116
            D+++   + + F +DG+++  G+ +  + G+V+SLL+ ERV LN+LQ++ GIA++TA  V
Sbjct  68   DAEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  117  EELGDPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDALMLKENHiaastsiaaa  176
            E LGD  I+V DTRKT+P LR+F+K+AVR+GGG NHRF L DA+MLK+NHIAA  S+  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  177  iekarayaGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEA  236
            I +ARAYA  +  +EVE  +L    EA AA  D+IM+DN + E I   ++ +++  + E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  237  SGGITMANLRQFANTGVDFLSLGFLTHSVVALDLSM  272
            SG I M+ + +F   ++D++S G LTHS  +LD+SM
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

459) GWCH70_2530 in NC_012793


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (550),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 107/267 (41%), Positives = 171/267 (65%), Gaps = 6/267 (2%)

Query  16   EDIGEHDITSEMIFPENEWATGTFTAKEDGVLAGTDIITIGYRLLHPGI---DVTLYKRD  72
            ED+  +D +++ IF ++  A  ++ AKE GVLAG  ++   + L+++ +   +   +K D
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK-D  81

Query  73   GEQVKKEETIAVVSGPVIPLLTGERVILNLLQRMSGIATLTHQAVMILNSSHTRICDTRK  132
            G+++   + +  + G+V +LLT ERV LN+LQ++SGIA++T   V  L   + ++ DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  133  TTPGLRMLEKYAVVCGGGYNHRFGLYDGVMIKDNHIAFCGSITKAVRAVRAKLGHMVKIE  192
            TTP LR++EKYAV  GGGYNHRF L D++M+KDNHIA  GS+ KA+   RA    +  +E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  193  VETETKEQVLEAVEAGADVIMFDNRTPEEVREFVSLVPKPIVTEASGGITLENLAAYGTT  252
            VE E+     EA  AG D+IM+DN + E++ + ++L++     E SG I +  ++ +   
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGL  261

Query  253  GVDYISLGMLTHSAKALDISFHLQGWN  279
            ++DY+S G LTHSAK+LD  F ++G  
Sbjct  262  AIDYVSSGSLTHSAKSLD--FSMKGLT  286

460) Dret_1371 in NC_013223


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (548),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 118/274 (44%), Positives = 177/274 (65%), Gaps = 6/274 (2%)

Query  16   LEHHLDLTLKEDGR--DLTSEAVFAVSDVSQGKVVAKQEGVLAGIPLVPLVLDKCAPTDG  73
            +++ L  +L+ED +  D +++A+F   + ++  + AK+ GVLAG+ +   V+    +   
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA--E  70

Query  74   PGWELDFSLPDGTWLWPGTVVARFTGQTRHLLQAERVILNFVCHLSGIATLTAHYARLIS  133
               +    + DG +L +G +V  + G  R LL  ERV LNF+ HLSGIA++TA Y   ++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  134  DSRTRLLDTRKTLPGLRYLEKYAVLVGGGTNHRMDLEEMVMLKDNHIDRAGSISQAVARV  193
            D R +++DTRKT P LR +EKYAV VGGG NHR +L + +MLKDNHI   GS+ +A+A+ 
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  194  RTQYTP-CPPIEVECRTLaeveeaaaakveRIMLDNMDLPTLEAALERIPSTIESEISGG  252
            R+ Y+P    +EVE  +LA  EEAAAA V+ IMLDNM L  +E A+  I++    E SG 
Sbjct  191  RA-YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  253  VDETTIARLAECGADFISVGRLTHSAPALDLSMR  286
            +D TTI+R+   + D++S G LTHSA +LD+SM+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

461) Hore_00640 in NC_011899


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (549),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 118/271 (44%), Positives = 178/271 (66%), Gaps = 2/271 (0%)

Query  8    LEKVIIEALEEDIGFGDLTTDYLIPSTHRSSGKIIVKEDgvvagvgvaRSVFEAVNSKIE  67
            ++  +  AL ED+   D +T+ ++    ++   ++ KE GV+AG+ V + VF   ++ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   FKA--MVRDGDQVRAGDVIIKITGPTAGILKGERTALNFMQRLSGIATKTCRLVTKVKDF  125
            F+     +DGD++ +GD+++ I G+  ++L  ER ALNF+Q+LSGIA+ T   V  + D 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  126  PVRVVDTRKTTPTLRQLEKYAVRVGGGYNHRFGLYDAVMVKDNHIKAAGGIKKAVTTLRR  185
             ++V DTRKTTP LR +EKYAVRVGGGYNHRF L DA+M+KDNHI A G+++KA++  R 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  186  NIPHTTKIevevttlteveealeaGADIIMLDNMDIETMAEAVKQIEGKALVEASGGIDE  245
              P    +EVEV +L+  EEA  AG DIIMLDNM +E + +A+  I G++ +E SG ID 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  246  NTIIEVARTGVDVISVGALTHQIESLDISLN  276
             TI      ++D +S G+LTH   SLD+S++
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

462) nadC-2 in NC_021908


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (548),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 113/260 (44%), Positives = 179/260 (69%), Gaps = 5/260 (1%)

Query  29   ITSASVIPSDHRSTVVMAARQPGVIAGLDAADLAFTLVDPEIVMR--RHIEDGDAVKSGD  86
             ++ +++  + ++ V + A+++GV+AGL   +  FTL D+E+  +  +++ DGD + SGD
Sbjct  30   YSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGD  89

Query  87   VIATIEGPSRGLLTGERTALNFLGHLsgiatvtagiaaaisgtkasVACTRKTTPGLRAL  146
            ++  I G+ R+LLT ER ALNFL HLSGIA++TA+   A+++ +  V  TRKTTP LR +
Sbjct  90   LVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLF  149

Query  147  EKYAVRAGGGMNHRFALYDAVLIKDNHVAISGGVAEAIRRARAGVGHLVKIEVEVDRLDQ  206
            EKYAVR GGG NHRF L DA+++KDNH+A  G+V  AI +ARA    +  +EVEV+ L  
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAA  209

Query  207  LQEAMAVGVDAVLLDNMTPDQLREAVAIVAGRAITEASGRVTPataaaiaaSGVDLISVG  266
             +EA A GVD ++LDNM+ +Q+ +A++++AGR+  E SG +  +T + + + ++D +S G
Sbjct  210  AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  267  WLTHSAPVLDI---GLDFVE  283
             LTHSA  LD+   GL +++
Sbjct  270  SLTHSAKSLDFSMKGLTYLD  289

463) nadC in NC_007765


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (549),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 114/260 (44%), Positives = 179/260 (69%), Gaps = 5/260 (1%)

Query  29   ITSASVIPSDHRSTVVMAARQPGVIAGLDAADLAFTLVDPEIVMR--RHIEDGDAVKSGD  86
             ++ +++  + ++ V + A+++GV+AGL   +  FTL D+E+  +  +++ DGD + SGD
Sbjct  30   YSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGD  89

Query  87   VIATIEGPSRSLLTGERTALNFLGHLsgiatvtagiaaaisgtkasVACTRKTTPGLRAL  146
            ++  I G+ RSLLT ER ALNFL HLSGIA++TA+   A+++ +  V  TRKTTP LR +
Sbjct  90   LVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLF  149

Query  147  EKYAVRAGGGMNHRFALYDAVLIKDNHVAISGGVAEAIRRARAGVGHLVKIEVEVDRLDQ  206
            EKYAVR GGG NHRF L DA+++KDNH+A  G+V  AI +ARA    +  +EVEV+ L  
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAA  209

Query  207  LQEAMAVGVDAVLLDNMTPDQLREAVAIVAGRAITEASGRVTPataaaiaaSGVDLISVG  266
             +EA A GVD ++LDNM+ +Q+ +A++++AGR+  E SG +  +T + + + ++D +S G
Sbjct  210  AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  267  WLTHSAPVLDI---GLDFVE  283
             LTHSA  LD+   GL +++
Sbjct  270  SLTHSAKSLDFSMKGLTYLD  289

464) Bmul_0790 in NC_010084


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (548),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 97/230 (43%), Positives = 160/230 (70%), Gaps = 3/230 (1%)

Query  64   LCGVPWFDAVVARIDPSIAVQ--WRYREGERMTADSVVCELEGPARALLTAERNALNFLQ  121
            L G+  F+ V + +D+ ++ Q   ++++G+R+T++ +V E+ G+ R+LLT ER ALNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YV+ + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALNAGVP-VQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A G + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMR  290
            A+ + AG++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

465) nadC in NC_010804


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (548),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 97/230 (43%), Positives = 160/230 (70%), Gaps = 3/230 (1%)

Query  64   LCGVPWFDAVVARIDPSIAVQ--WRYREGERMTADSVVCELEGPARALLTAERNALNFLQ  121
            L G+  F+ V + +D+ ++ Q   ++++G+R+T++ +V E+ G+ R+LLT ER ALNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YV+ + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALNAGVP-VQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A G + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMR  290
            A+ + AG++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

466) Desaf_2918 in NC_016629


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (550),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 116/273 (43%), Positives = 182/273 (67%), Gaps = 4/273 (1%)

Query  20   AAIRSALAED--GPDLTSVAVFGQDVVMRASIVAKEPGILAGLPIVPLVLADVEPQGNWI  77
             ++++AL ED  + D ++ A+F+++   + S+ AKE+G+LAGL +   V++  +++    
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  78   VENAASDGQSVEPGQTVARLCGPAAVLLRAERIALNFICHLSGIATATASYAQRLSGtrt  137
              +   DG+ + +G+ V  + G+   LL  ER+ALNF+ HLSGIA+ TA+Y + L++ R 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  138  rlldtrktlPGLRYPEKYAVRIGGGLNHRMNLFEMLMLKDNHIDRAGSITEAVKILRAAY  197
            +++DTRKT P LR  EKYAVR+GGG NHR NL + +MLKDNHI   GS+  A+   R AY
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR-AY  193

Query  198  KP-CPPIEVECRTLDEVREAASLRVERIMLDNMDLATMEKALALVPSGIETEVSGGVNLE  256
             P    +EVE  +L    EAA+  V+ IMLDNM L  +E+A++L+++    E SG +++ 
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  257  TIGAIGKLGPDFVSVGALTHSAKALDLSMRVLA  289
            TI+ +  L+ D+VS G+LTHSAK+LD+SM+ L+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

467) Pfl01_0785 in NC_007492


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (549),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 118/279 (43%), Positives = 200/279 (72%), Gaps = 7/279 (2%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRDAAVISGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK ++++++A+V++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVRDGERVSPNQPLFHLEGPARSLLTGERSALNFLQLLSGVATR-AQY  121
             +D+ V+ +   Q +DG+R+++ + ++++ G+ RSLLT ER ALNFLQ LSG+A+  A Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  LADFVAETSVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAASGGIP  181
            +   +++  +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ 
Sbjct  126  VEA-LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  QAIAAAHKIAP-GKPVeievesleelkealaagaDIIMLDELSLDDMREAVRLNAGKAKL  240
            +AIA A+  AP  K VE+EVESL    EA AAG DIIMLD++SL+++ +A+ L AG++++
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  241  EASGGINESTLLPIAQTGVDYISIGAMTKDVKAVDLSMR  279
            E SG I+ +T+  +   ++DY+S G++T   K++D+SM+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

468) Synpcc7942_0951 in NC_007604


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (549),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 119/283 (43%), Positives = 184/283 (66%), Gaps = 11/283 (3%)

Query  2    LPPWILLDPILSDWLREDLGRGDHSAQGLGLEGTTGKATWVAKSEGIIAGLPIAFRMLQL  61
            L P   +D  L   LRED+   D S++++  +   +K +  AK  G++AGL +  R++ L
Sbjct  8    LTPF-QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  62   LDPQVKCTAKLAEGFACG----SGQVIAELEGPLASLLSGERAALNVAMRLSGVATATRR  117
            +D++V  T + ++ F  G    SG+++ E+ G++ SLL+ ER ALN   +LSG+A+ T  
Sbjct  67   FDAEV--TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  118  FVDQLADLPTQFVDTRKTTPGLRLLEKYATRVGGGTNHRLGLDDAVMVKDNHiaaaggsi  177
            +V+ L+D   +  DTRKTTP LRL+EKYA RVGGG NHR+ L DA+M+KDNHIAA G+  
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  178  aaaiKKLRSQLPFPLIIEVETETLGQVMEAISAGVGVIMLDNMNLAQVQAAVQVIRDRAP  237
             A  +  R+  PF  ++EVE E+L+   EA +AGV++IMLDNM+L Q++ A+ +I   A 
Sbjct  185  KAIAQA-RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AG  240

Query  238  RTKIEVSGNISLENIRAIAETGVDYISSSAPITRSPWLDISMR  280
            R++IE SGNI +  I  +   ++DY+SS++    +  LD+SM+
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

469) MDS_0892 in NC_015410


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (548),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 193/278 (70%), Gaps = 5/278 (1%)

Query  7    AELSS-EIEANVRRALAEDIGSGDITAQLIPAER-LASARVITREEAVICGTAWVDAVFR  64
            ++L++ +I+  ++ AL ED+ S D +++ I  ++  A   ++++E +V+ G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVQDGDRVHADQTLFTLEGPARALLSGERSALNFLQTLSAVATRCRHY  122
             +D+ V+ +   Q +DGDR+ +++ ++ + G+ R+LL+ ER ALNFLQ LS++A+    Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADIVEGTQVKLLDTRKTIPGLRLAQKYAVTCGGCHNHRIGLFDAFLIKENHIAACGGIAK  182
             + + + ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AISAAHQIAP-GKPvevevesleelrealeagaDIVMLDELSLEDMREAVKLTAGRAKLE  241
            AI+ A+  AP  K VEVEVESL    EA  AG DI+MLD++SLE++ +A+ L AGR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINGSTLRVIAETGVDYISLGTLTKDVKAVDLSMR  279
             SG I+ +T+  +   ++DY+S G+LT   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

470) Aaci_2478 in NC_013205


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (547),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 110/271 (41%), Positives = 178/271 (66%), Gaps = 8/271 (2%)

Query  9    DLVRLALAEDLGRGDLTTEAVIPADATARASVWIKEPSRVCGTEVAAWVF--HEVDPGLQ  66
            D ++ AL ED+   D +T+A++  ++ A+ S+  KE++ + G  V  +VF   + +  +Q
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  67   VTVACADGIDLDGPRVVMRVEGAARSILGAERTALNFLSRLTGIATAARDAVREIAGTRA  126
                  DG  L +  +V+ + G+ RS+L  ER ALNFL +L+GIA+ +   V  +++ R 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  127  RILDTRKTTPGWRALEKYAVRVGGGWNHRFALDDMVLIKDNHIAIAGGVREAVSRAKARA  186
            +++DTRKTTP  R +EKYAVRVGGG NHRF L D +++KDNHIA  G+V+ A+++A+A A
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  187  GFAHKIevevesleqleeAIAAGADVVLLDNMDLEIMREAVRRTGGRVPLEASGNM---R  243
             F   +EVEVESL   EEA AAG D+++LDNM LE + +A+   +GR  +E SGN+    
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  244  PGRLRAVADTGVDFISMSHITMRAQAVDVGL  274
             +R+R++A   +D++S + +T  A+++D ++
Sbjct  255  ISRFRGLA---IDYVSSGSLTHSAKSLDFSM  282

471) H924_05010 in NC_020506


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (549),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 187/278 (68%), Gaps = 14/278 (5%)

Query  6    LDAIVSAALKEDAPWGDITSENLVPATAVMTARLVAREPGVFSGVELVKTAFHQVDQTLS  65
            +D  + AAL+ED    D +++ +    +     L A+E+GV++G+    T F++V   + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGL----TVFQRVFTLFD  68

Query  66   VELFIRDGAAFNAGDTLAT------ITGSarailraerialNFVQRTSAIATLTARYVDA  119
             E+ +++   F+ GD L++      I GS R++L  ER+ALNF+Q+ S+IA++TA YV+A
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  120  IAGTKARIVDTRKTTPGLRLIERQAVRDGGGFNHRSTLSDAVMVKDNHLASLLSEGISVT  179
            +++ + ++ DTRKTTP LRL+E+ AVR GGG+NHR  LSDA+M+KDNH+A++ S   +++
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  180  EALLALRAKIPHTTHIEVEVDRLDQIDAVLAAGVDTIMLDNFSLADLEKGVAQIAGRALV  239
            +A    RA  P    +EVEV+ L   +   AAGVD IMLDN SL ++E++++ IAGR+ +
Sbjct  189  QA----RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  240  EASGGVNLNTVADIARTGVDIISVGALTHSIKALDLGL  277
            E SG +++ T++ +   ++D +S G+LTHS K+LD+++
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

472) nadC in NC_017668


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (547),  Expect = 2e-37, Method: Compositional matrix adjust.
 Identities = 106/259 (41%), Positives = 175/259 (68%), Gaps = 2/259 (0%)

Query  16   EDIGDQDVTSDFLFPEDAEGELHFVSKQSGIFCGSEIIREGYQLLDPSIMIELYTQ--DG  73
            ED+  +D +++ +F +++++ + + +K++G++ G  +++  + L+D+ + ++   Q  DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  74   TEVGSGECIAAIQGPIVNLLKGERVILNLIQRMSGIATNTKRAVETLNNQETKICDTRKT  133
              + SG+ +  I G++ +LL  ERV LN++Q++SGIA+ T   VE+L ++  K+ DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  134  TPGLRMFEKYAVRMGGGVNHRYGLYDAVMLKDNHIAFAGSILKAVEIVRAKLGHMVKIEV  193
            TP LR+FEKYAVR+GGG NHR+ L DA+MLKDNHIA  GS+ KA+   RA    +  +EV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  194  ETETEAQVKEAVQARADCIMFDNRSPEEISTLVKFVPSHITTEASGGIHLNNLAAYRESG  253
            E E+ A   EA  A  D IM+DN S E+I   + +++++   E SG I++  ++ +R  +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  254  VDYISLGALTHSATSLDIS  272
            +DY+S G+LTHSA SLD+S
Sbjct  263  IDYVSSGSLTHSAKSLDFS  281

473) BCO26_0445 in NC_015634


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (547),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 173/275 (63%), Gaps = 4/275 (1%)

Query  1    MNKLQLQSMLKHFFMEDIGEGDINTEYIFSPNQPGKLTFIAKQNGIFCGKDVIEEGFRIL  60
            +  +Q++  LK  + ED+   D +T+ IF  +  +K++++AK+ G++ G  V++  F ++
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DGTV---RPRIFPRDGARIEKGAAIAEIRGPIVSLLSGERVILNLIQRMSGIATTTNAAV  117
            D+ V    P+ F +DG R+  G  + EI G++ SLL+ ERV LN++Q++SGIA+ T A V
Sbjct  68   DAEVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  118  RETEGTHAKICDTRKTTPGLRMLEKYAVKAGGGFNHRRGLYDCVMLKDNHIAFAGSITKA  177
                + + K+ DTRKTTP LR++EKYAV+ GGG+NHR  L D +MLKDNHIA  GS+ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  178  VETVKASIGHTVKIEVEIETKDHLLEAVRAGADIIMFDNRTPEEICEWLPHVPPHIATEA  237
            +   +A       +EVE+E+     EA  AG DIIM+DN + E+I + +  ++ +   E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  238  SGGITMENIRSYAETGVDWISLGFLTHSYQILDIS  272
            SG I M  I  +   ++D +S G LTHS + LD+S
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

474) Cpha266_2293 in NC_008639


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (547),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 110/269 (41%), Positives = 176/269 (66%), Gaps = 8/269 (2%)

Query  20   ALEEDRYIGDITTLSTIDDNRVGRAEVRAKEDGILAGAEVARQVFAACDGAVSVVCHH--  77
            AL ED    D +T + +D++  ++  + AKE G+LAG  V ++VF+  D+ V+    H  
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  78   SDGDQLMVGDLVLEVSGKLAPLLVGERTALNFMQRMSGIATKTKLFVEKVSHTKASILDT  137
             DGD+L  GDLVLE+ G + +LL  ER ALNF+Q++SGIA+ T  +VE +++ +  ++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  138  RKTAPGLRYFDKEAVRIGGGRNHRFGLFDMMLIKDNHIDASGGVANALRKARQYRKKHGL  197
            RKT+P LR F+K AVR+GGG NHRF L D +++KDNHI A G+V +A+ +AR Y     +
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY---APF  196

Query  198  AVKIETEVRSIDELREALSCKPDIVLLDNFGIDLLSDAVAFSKENYPMVILEASGNVGLH  257
               +E EV S+    EA +   DI++LDN +++ + +A+++         +E SGN+++ 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR---SRIECSGNIDMT  253

Query  258  NVAQIAETGVDYISIGELTHSVKALDLSM  286
             ++++   ++DY+S G LTHS K+LD+SM
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

475) HYPDE_28518 in NC_021172


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (547),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 109/271 (41%), Positives = 182/271 (68%), Gaps = 3/271 (1%)

Query  19   VEAAVRSALDEDLGLAGDITTNATVAPDTVAEAVIAARRPGVIaglalaeaafraVGPET  78
            ++ ++++AL ED+  + D +TNA    +  A   + A+ +GV+AGL++ +  F   ++E 
Sbjct  13   IDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  79   HF--SIEIGDGETVEPGTVIARVSGNARTLLTAERVALNFLGRLSGIATLTRQYVDQIAG  136
             F  + ++ DG+ + +G ++  + G+ R+LLT ERVALNFL +LSGIA++T  YV+ +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  137  MHAKIVDTRKTTPGLRAFEKYAVRCGSGYNHRVGLFDAVLIKDNHIvasggvaaavraak  196
             + K+ DTRKTTP LR FEKYAVR G+GYNHR  L DA+++KDNHI A G+V  A+  A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  197  aatgHMTKIEVEVDTLAQLEIVMREKVDCVLLDNMTPGDLAKAVNIVGGRCLTEASGGVN  256
            A +  +  +EVEV++LA  E      VD ++LDNM+  ++ +A+ +++GR   E SG ++
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  257  LETVKEIAQTGVDLISVGALTHSASVLDLGL  287
            + T+  +   ++D +S G+LTHSA  LD+++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

476) Spiaf_2833 in NC_017098


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  149 bits (547),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 113/280 (41%), Positives = 180/280 (65%), Gaps = 14/280 (5%)

Query  14   LDAIVELAIREDVGSGDMTSRTAV--HAELQLEHVCRVKQDGVIAGLGLMQQVFARIDPA  71
            +D  +  A+REDV S D ++ +    H++ ++      K+ GV+AGL + Q+VF+ +D+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLF--AKEAGVLAGLTVFQRVFTLFDAE  70

Query  72   ISCE--LLVSEGAEVVAGTEVALVRGSARSILTAERTALNFLQRMSGIATEARRYVRAIE  129
            ++ +      +G  + +G  V  + GS RS+LT ER ALNFLQ++SGIA+ +  YV A+ 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  130  GTGAKILDTRKTAPGLRAADKLAVRLGGGVNHRFGLFDMIMIKDNHIAAAGGITAALMRV  189
            +   K++DTRKT+P LR  +K AVR+GGG NHRF L D IM+KDNHIAA G++  A+   
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI--A  188

Query  190  QRENYGRLP--VEVEVASVAQLTELLPLVDDPGVDRVLLDNMSLVELRECVALVDGRVPL  247
            Q   Y+ +   VEVEV S+A   E       +GVD ++LDNMSL ++ + ++L+ GR  +
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEE----AAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  248  EASGNVTLKTVGEIAATGVEYISVGSLTHSVAALDIHLDS  287
            E SGN+ + T++ + + +++Y+S GSLTHS  +LD+ + +
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

477) Theam_1256 in NC_014926


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (546),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 111/240 (47%), Positives = 163/240 (68%), Gaps = 6/240 (2%)

Query  39   IAKEECLLCGLPFARKVFSLYDPSVEFTPllgegellK--PGTVFARVEGPVSSILTCER  96
            +AKE  +L GL   ++VF+L+D+ V F       +  +  +G +   + G+V S+LTCER
Sbjct  47   FAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCER  106

Query  97   TALNLLQRLSGIATNTRRFVEALKGSRVKLLDTRKTTPGLRLFEKYATRVGGALNHRFGL  156
             ALN+LQ+LSGIA+ T  +VEAL + R+K++DTRKTTP LRLFEKYA RVGG+ NHRF L
Sbjct  107  VALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNL  166

Query  157  YDAVMVKDNHIAACGGVEEAVRRVCAVKPATAKVEVEVQNWNELRQLLPVLDLVDIVMLD  216
             DA+M+KDNHIAA G+V+ A+ +  A  P    VEVEV++     +  +    VDI+MLD
Sbjct  167  SDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEE--AAAAGVDIIMLD  224

Query  217  NWpleevpeavellRKRSSVKIELSGGITLDTLKRVAALPVDYVSTSKLITAATWVDLSV  276
            N +LE++ +A+ L+  RS  +IE SG I + T+ R  +L++DYVS++ L  +A  +D+S+
Sbjct  225  NMSLEQIEQAITLIAGRS--RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

478) Bamb_2552 in NC_008390


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (546),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 99/230 (44%), Positives = 159/230 (70%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEAVIARIDPSIVVQ--WRYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ +  Q   ++++GDR+T++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVASATRRYVDRVEGTRAKILDTRKTLPGLRLAEKYAVRVGGGENQRLALYDGILIK  181
             LSG+AS T  YV+ + + R K++DTRKT P LRL EKYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALDSGVP-VQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A G + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMR  290
            A+ + AG++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

479) Ththe16_1003 in NC_017272


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (545),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 121/282 (43%), Positives = 195/282 (70%), Gaps = 4/282 (1%)

Query  3    GVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEEGVLAGLWVAE  62
            ++++  L    ++++L+A LRED+   D ++  +  ++ ++   ++AKE GVLAGL V +
Sbjct  2    SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  63   RVFALADPRTAF--TPLVAEGARVAEGTEVARIRGPLRGILAGERLALNLLQRLSGIATL  120
            RVF+L D+  +F       +G R++ G  V  I G++R++L+ ER+ALN+LQ+LSGIA++
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  121  TRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRNHRYGLFDGILIKENHvraag  180
            T AYVEAL++ + +++DTRKTTP LR +EKYAVRVGGG NHR+ L D+I++K+NH+ A G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  181  gvgeavrrakaraPHYLKvevevrdl-aeleealeagadlvlldNFPLEALREAVRRVRG  239
            +V  A+ +A+A AP ++K+     +  A  EEA  AG D+++LDN +LE + +A+  + G
Sbjct  182  SVQKAIAQARAYAP-FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  240  RVPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSL  281
            R  +E SGN+ +         ++DYVS G+LTHSAK+LD+S+
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

480) Desmer_0088 in NC_018515


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (546),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 114/274 (42%), Positives = 182/274 (67%), Gaps = 3/274 (1%)

Query  3    ATFQFQELIDRALIEDIGTGDLSTK-IFPNDLTSMAKLYAKQDGVVAGLELVEQVFQRVD  61
            + FQ+++ +  AL ED+ + D ST+ IF ++  +   L+AK+ GV+AGL + ++VF   D
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  62   PRI--EVCKLVKDGYEVKVGEVVIELNGPLSGILQGERTALNFLQHLSGIATATKRAVDQ  119
            + +  +     KDG  +  G++V+E+ G++ ++L  ER ALNFLQHLSGIA+ T   V+ 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  120  VSGLSTCIVDTRKTLPGWRSLQKYAVRVGGGQNHRFGLYDAVMLKDNHLTAVGGLTEAVK  179
            +++    + DTRKT P  R ++KYAVRVGGG NHRF L DA+MLKDNH++AVG++  A+ 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  180  RVRTTIGHMVKIevecetmeqveeavACGVDVIMLDNMKIDEMLLAVQYIDRRAIVEASG  239
            + R+    +  +EVE E++   EEA A GVD+IMLDNM ++++  A+  I  R+ +E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  240  GIQEGQLRQVAETGVDLISIGALTHSVRAMDFSL  273
             I+   + +    ++D +S G+LTHS +++DFS+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

481) Palpr_0188 in NC_014734


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (545),  Expect = 3e-37, Method: Compositional matrix adjust.
 Identities = 113/271 (42%), Positives = 176/271 (65%), Gaps = 14/271 (5%)

Query  15   EDIGDGDHTTLSCIPATAIGKSQLIIKENGVLAGVEVAREIFRAFDPELKMTV---FIKD  71
            ED+   D +T + +   + +K  L+ KE GVLAG+ V + +F  FD+E+       F KD
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF-KD  81

Query  72   GAEVKVGDIAFVVEGKIQSLLQTERLMLNIMQRMSGVATRTREYVKALEGTKTRVLDTRK  131
            G  +  GD+ + + G ++SLL  ER+ LN++Q++SG+A+ T  YV AL + + +V+DTRK
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRK  141

Query  132  TTPGLRLLEKEAVKIGGGVNHRIGLYDMILLKDNHVDFAGGIAQAIQRTKAY---LKEKG  188
            TTP LRL+EK AV++GGG NHR+ L D I+LKDNH+   G++ +AI +++AY   +K   
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK---  198

Query  189  KDLKIEIEVRSFDELAQVMAEGGVDRIMLDNFTPENTRKAVEIIGGKYETESSGGITFAT  248
                +E+EV S+   A+  A +GVD IMLDN + E+  +A+ +I+G+   E SG I  +T
Sbjct  199  ---MVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  249  LKDYAECGVDYISVGALTHSVKSLDMSFKAV  279
            +  +   ++DY+S G+LTHS KSLD S K++
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

482) AGROH133_12921 in NC_015508


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (545),  Expect = 4e-37, Method: Compositional matrix adjust.
 Identities = 121/278 (44%), Positives = 184/278 (67%), Gaps = 3/278 (1%)

Query  4    TPLPRIIVEPLVRNALLEDLGLAGDITSAAVIPAGHRSVVVMAAREPGVIAGLDAAELAF  63
            T L  + ++  ++ AL ED+  + D ++ A++    ++ V + A+E+GV+AGL   +  F
Sbjct  6    TDLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  64   ELVDPTIVMR--RQVQDGAAVTPGDIIATIEGPSRGLLTAERTALNFLGHLSGiasvtat  121
             L D+ +  +  +Q +DG  +T+GD++  I G+ R+LLT ER ALNFL HLSGIAS+TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  122  iaaaisgtkasVACTRKTTPGLRALEKYAVRAGGGMNHRFALYDAVLIKDNHIAVAGGVR  181
               A+++ +  V  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHIA  G+V+
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  DAIRSAKAGVGHLVKIEVEVDTLLQLREAMEEGVDAVLLDNMPPEQLREAVQIVAGRAIT  241
             AI  A+A    +  +EVEV++L    EA   GVD ++LDNM+ EQ+ +A+ ++AGR+  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  242  EASGRitpqtaaaiaatgiDLISVGWLTHSAPVLDIGL  279
            E SG I   T + + + +ID +S G LTHSA  LD+++
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

483) Bcer98_3144 in NC_009674


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (544),  Expect = 4e-37, Method: Compositional matrix adjust.
 Identities = 113/274 (42%), Positives = 184/274 (68%), Gaps = 2/274 (0%)

Query  1    MNILKVQEALKQFFLEDIGEWDITSQCIFPDYLEAKGTFLIKEAGVFAGRSVIEAGFQLI  60
            +  ++++++LK  + ED+   D +++ IF +  +AK +++ KEAGV+AG +V++  F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DERIAVELHK--KDGDLVEKGEIIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVL  118
            D  ++ +     KDGD +  G+++  + G++ SLLT ERV LN +Q++SGIA+MT   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  ALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAV  178
            AL+  + ++ DTRKT P LR+F+KYAV  GGG+NHRF L D++M+KDNHIA  GS+ KA+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  TSVKEKLGHMvkveveteteeqvreavaaGVDIIMFDNRTPDEIREFSKIVPSAIVTEAS  238
            +  +     +  VEVE E+     EA AAGVDIIM+DN + ++I +   ++++    E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGIKIEDLSKYGKTGVDYISLGALTHSVKALDIS  272
            G I +  +S++   ++DY+S G+LTHS K+LD+S
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

484) KKY_900 in NC_016078


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  148 bits (544),  Expect = 4e-37, Method: Compositional matrix adjust.
 Identities = 113/272 (42%), Positives = 184/272 (68%), Gaps = 3/272 (1%)

Query  14   IERAVTAALDEDLGQAGDITSQATISPDALAVARVNARTPGVICGLDCAVSAFSLIGPG-  72
            I+ ++ AAL ED+ ++ D +++A +  ++ A   + A+ +GV+ GL      F+L+++  
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  73   -LETELLVADGAIVEAGDAILEIRGNARSLLAAERTALNFLTHLSGIATLTRSFAMQTVG  131
             ++      DG  + +GD +LEI G+ RSLL+ ER ALNFL HLSGIA++T ++     +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  132  TAAHICCTRKTTPGLRALEKYAVRCGGGHNHRFGLSDAILIKDNHiavaggvadaiaaak  191
                +  TRKTTP LR +EKYAVR GGG NHRF LSDAI++KDNHIA  G+V  AIA A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  192  afagHLVAIEVEVDTLGQLEEALSAGANAILLDNMDEETLARAVAVTAGRAKLEASGNVT  251
            A+A  +  +EVEV++L+  EEA +AG + I+LDNM  E + +A+++ AGR+++E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  252  LERVAPIARTGVDYISTSRITTAATPLDLGLD  283
            +  ++ +   ++DY+S++ +T +A +LD+++ 
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

485) Sthe_2195 in NC_013523


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 124/266 (47%), Positives = 188/266 (71%), Gaps = 5/266 (1%)

Query  13   ALAEDLGTGDVTTLATVPEGLQASGYLLAKSPGVLSGLEVAALVFHEVDPAITFE--PLA  70
            AL ED+ + D +T A   +  QA   L+AK +GVL+GL V   VF   D+ +TF+     
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  71   ADGDRIAPGQHLARVSGPARGILSAERVALNFLQRLSGVATLTARYVEAVEGTGARIIDT  130
             DGDR+++G+ +  + G+ R++L+ ERVALNFLQ+LSG+A++TA YVEA+ +   +++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  131  RKTTPGMRLLEKAAvrhggghnhrvgLSDGVLIKDNHLAAIGGSDriaravaaarafaPH  190
            RKTTP +RL+EK AVR GGG NHR  LSD++++KDNH+AA+G+ +   +A+A ARA+AP 
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ---KAIAQARAYAPF  196

Query  191  TLRIEVEVTSLEELDQALAAGADVILLDNMPIPMMAEAVRRTAGRAILEASGGITLETVR  250
               +EVEV SL   ++A AAG D+I+LDNM++  + +A+   AGR+ +E SG I + T+ 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  251  QVAETGVDLISSGALTHSAPALDISL  276
            +    ++D +SSG+LTHSA +LD+S+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSM  282

486) H681_04965 in NC_020829


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (543),  Expect = 5e-37, Method: Compositional matrix adjust.
 Identities = 116/272 (43%), Positives = 186/272 (69%), Gaps = 4/272 (1%)

Query  12   EIQANVRAALAEDVGSGDITAQLIPAER-DASARIITRENATVAGSAWVDEVFRQVDPRV  70
            +I+  ++AAL EDV S D +++ I  ++ +A   ++++E + +AG +  + VF   D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   --QVKWQARDGDRVSADQTLFTLEGPARALLTGERSALNFLQLLSGTATRARHYADLVDG  128
              Q   Q +DGDR+++++ ++ + G+ R+LLT ER ALNFLQ LSG A+ +  Y + +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TGVKLLDTRKTLPGLRLAQKYAITCGGCHNHRIGLYDAFLIKENHiaacggiaqaiataq  188
              +K++DTRKT P LRL +KYA+  GG  NHR+ L DA+++K+NHIAA G++ +AIA A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  riaP-GKPVEIEVEDLAELRQALDAGADIIMLDELSLDDMRTAVALTAGRARLEASGGIT  247
              AP  K VE+EVE LA   +A  AG DIIMLD++SL+++  A++L AGR+R+E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  EATLRSVAETGVDYISIGTLTKDVTALDLSMR  279
             +T+      ++DY+S G+LT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

487) L483_03950 in NC_021491


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (543),  Expect = 5e-37, Method: Compositional matrix adjust.
 Identities = 115/278 (42%), Positives = 197/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERATANQPLFHLEGPARSLLSGERSALNFLQLLSGVATRARAL  122
             +D+ V+ +   Q  DG+R T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ + A 
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVAGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvaq  182
             + +++ +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVEIEVESLDELREALAAGADIIMLDELNLDEMREAVRITAGKAKLE  241
            A+A A+  AP  K VE+EVESL    EA AAG DIIMLD+++L+++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

488) Chro_5597 in NC_019695


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (542),  Expect = 6e-37, Method: Compositional matrix adjust.
 Identities = 124/281 (45%), Positives = 181/281 (65%), Gaps = 7/281 (2%)

Query  7    LPPWLILDPLLREWLSEDVGRGDRTTQSLLAQNPRTGQAKWVAKAPGVIAGLPVAARVFQ  66
            L P  I D  L+  L EDV   D +T++++ ++ ++ +    AK +GV+AGL V  RVF 
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQA-KVSLFAKEAGVLAGLTVFQRVFT  65

Query  67   TLDEQVTFVACAA--EGELCQPGQVIAQMSGALDALLMGERVALNLAMRLSGIASLTRQY  124
             +D +VTF       +G+   +G+++ ++ G++ +LL  ERVALN+  +LSGIAS+T  Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  125  VERIEDLPARLVDTRKTTPGLRVLEKYATQLGGAINHRMGLDDAVMIKDNHiavaggigk  184
            VE + D   ++ DTRKTTP LR++EKYA ++GG+ NHR  L DA+M+KDNHIA  G++ K
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  185  aiaqiRQSIPYPLTIevetesseqvseAIQYGADIIMLDNMSLEMMHQAVETIRQHNSKI  244
            AIAQ R   P+   +EVE ES     EA   G DIIMLDNMSLE ++QA+  I    ++ 
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRS  242

Query  245  KIEASGNVSLETICSVAETGVDYISSSAPITQAKWLDLSMK  285
            +IE SGN+ + TI      ++DY+SS++    AK LD+SMK
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

489) Spith_1063 in NC_017583


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (541),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 112/256 (44%), Positives = 172/256 (68%), Gaps = 7/256 (2%)

Query  31   TSKAIFPPEAEGAARVVSKGEGILAGDFVFERVFRKINERISVSFLRQ--DGDVLSRGDV  88
            +++AIF  ++++   + +K  G+LAG  VF+RVF  ++  ++    +Q  DGD L+ GD+
Sbjct  31   STNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDL  90

Query  89   VAELSGPMADLLTGERIALNFLAFLSGIATYTSKFVKEAGKSGHTVILDTRKTLPGFRRL  148
            V E+ G++  LLT ER+ALNFL  LSGIA+ T+ +V   G  ++  ++DTRKT P +R +
Sbjct  91   VLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG-DDRIKVFDTRKTTPNLRLF  149

Query  149  SKYAVRIGGGENHRMGLYDMVLIKDNHIDGAGSITKAVERVRERWGDRF--KIevecrtv  206
             KYAVR+GGG NHR  L D +++KDNHI + GS+ KA+ + R      F   +EVE  ++
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY--APFVKMVEVEVESL  207

Query  207  eeveeALGAGVHIIMLDNMSPSEMEESIRRGRGKVLFECSGDMDLPKIAEVSKLGVDYIS  266
               EEA +AGV+IIMLDNMS  ++E++I    G+  +ECSG++D+  I+    L++DY+S
Sbjct  208  AAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVS  267

Query  267  VGRITHSAPAFDFSMK  282
             G +THSA ++DFSMK
Sbjct  268  SGSLTHSAKSLDFSMK  283

490) MYA_2270 in NC_017920


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (542),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 97/230 (43%), Positives = 159/230 (70%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEAVIARIDPSIVVQ--WRYREGDRMTADSTVCELDGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ +  Q   ++++GDR+T++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YV+ + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALNAGVP-VQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A G + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMR  290
            A+ + AG++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

491) nadC in NC_017467


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (541),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 99/237 (42%), Positives = 166/237 (71%), Gaps = 3/237 (1%)

Query  37   SFIAKQSGIICGQEIPQATYDLL-GHATYK--PRIPDGAPVKAGDIIGTVSGTAQTLLSG  93
            S++AK++G++ G  + Q  + L+ ++ T++   ++ DG  + +GD++  + G+ ++LL+ 
Sbjct  45   SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTC  104

Query  94   ERVTLNLIQRMSGIATQTTHFVKLLDDATIRITDTRKTAPGLRLFDKYAVSVGGGFNHRF  153
            ERV+LN++Q++SGIA+ T+ +V  L+D  I++ DTRKT+P LRLF+KYAV VGGG+NHRF
Sbjct  105  ERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRF  164

Query  154  DLTGGIMLKDNHIALAGGVTQALAAVKRHVGpltpveveveteeelRQAVAGGANVIMFD  213
            +L+++IMLKDNHIA  G+V +A+A  +     +  VEVEVE+     +A A+G ++IM+D
Sbjct  165  NLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  214  NQNPETIKQWRQLVPKTIKVEASGGITAESISTFKGCGADFISIGNLTNDVTPLDIS  270
            N + E I Q   L++   ++E SG I   +IS F+G + D++S G+LT+   +LD+S
Sbjct  225  NMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

492) R0052_11065 in NC_018528


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (541),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 99/237 (42%), Positives = 166/237 (71%), Gaps = 3/237 (1%)

Query  37   SFIAKQSGIICGQEIPQATYDLL-GHATYK--PRIPDGAPVKAGDIIGTVSGTAQTLLSG  93
            S++AK++G++ G  + Q  + L+ ++ T++   ++ DG  + +GD++  + G+ ++LL+ 
Sbjct  45   SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTC  104

Query  94   ERVTLNLIQRMSGIATQTTHFVKLLDDATIRITDTRKTAPGLRLFDKYAVSVGGGFNHRF  153
            ERV+LN++Q++SGIA+ T+ +V  L+D  I++ DTRKT+P LRLF+KYAV VGGG+NHRF
Sbjct  105  ERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRF  164

Query  154  DLTGGIMLKDNHIALAGGVTQALAAVKRHVGpltpveveveteeelRQAVAGGANVIMFD  213
            +L+++IMLKDNHIA  G+V +A+A  +     +  VEVEVE+     +A A+G ++IM+D
Sbjct  165  NLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  214  NQNPETIKQWRQLVPKTIKVEASGGITAESISTFKGCGADFISIGNLTNDVTPLDIS  270
            N + E I Q   L++   ++E SG I   +IS F+G + D++S G+LT+   +LD+S
Sbjct  225  NMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

493) R0052_11115 in NC_018528


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (541),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 99/237 (42%), Positives = 166/237 (71%), Gaps = 3/237 (1%)

Query  37   SFIAKQSGIICGQEIPQATYDLL-GHATYK--PRIPDGAPVKAGDIIGTVSGTAQTLLSG  93
            S++AK++G++ G  + Q  + L+ ++ T++   ++ DG  + +GD++  + G+ ++LL+ 
Sbjct  45   SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTC  104

Query  94   ERVTLNLIQRMSGIATQTTHFVKLLDDATIRITDTRKTAPGLRLFDKYAVSVGGGFNHRF  153
            ERV+LN++Q++SGIA+ T+ +V  L+D  I++ DTRKT+P LRLF+KYAV VGGG+NHRF
Sbjct  105  ERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRF  164

Query  154  DLTGGIMLKDNHIALAGGVTQALAAVKRHVGpltpveveveteeelRQAVAGGANVIMFD  213
            +L+++IMLKDNHIA  G+V +A+A  +     +  VEVEVE+     +A A+G ++IM+D
Sbjct  165  NLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  214  NQNPETIKQWRQLVPKTIKVEASGGITAESISTFKGCGADFISIGNLTNDVTPLDIS  270
            N + E I Q   L++   ++E SG I   +IS F+G + D++S G+LT+   +LD+S
Sbjct  225  NMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

494) Mlut_15690 in NC_012803


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (542),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 115/285 (41%), Positives = 180/285 (64%), Gaps = 13/285 (4%)

Query  16   DVERIVAAALAEDAPWGDVSSEAFVPEQARITARVVAREAGVLSGTNALEAAFRLVDPAV  75
            +++  + AAL ED    D S++A+  ++++    + A+EAGVL+G   ++  F L D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  76   SV--TLHLADGADLSPGTVVAEVPGPARSVLRAERVALNLVQRLSGIatttaahvaavra  133
            +     ++ DG  L++G +V E+ G+ RS+L  ERVALN++Q+LSGIA+ TAA V A+  
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  134  gggharvvDTRKTTPGLRVLERQAVRDGGGHNHRSSLSDAVMLKDNHlaalgfggagapg  193
            +       DTRKTTP LR++E+ AVR GGG NHR +LSDA+MLKDNH+AA+G    + + 
Sbjct  132  DRIKVF--DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  194  ealTAALRAGMARLPHTTHVEVEVDRLEQIPAVLAAGVDTIMLDNFSPAELRAGVELVAG  253
                A         P    VEVEV+ L       AAGVD IMLDN S  ++  ++ L+AG
Sbjct  190  ARAYA---------PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  254  RAVVEASGGVSLETIGAIAATGVDVISVGALTHTVRSLDLGLDAV  298
            R+ +E SG + + TI+ + + ++D +S G+LTH+ +SLD+++ ++
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

495) M5M_17925 in NC_018868


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (542),  Expect = 7e-37, Method: Compositional matrix adjust.
 Identities = 110/273 (41%), Positives = 177/273 (65%), Gaps = 7/273 (2%)

Query  18   VTAALQEDVGSGDITAQLIPAGQT-ASARVITREACTVAGSEWVNEVFRQLDPSVTV--T  74
            + AAL+EDV S D +++ I   +  A   ++++EA  +AG    + VF  +D+ VT    
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  75   WHVQDGERAQPNQLLYELSGNARSLMTGERAALNFLQMLSGVATTCREYADLVAHTQVKL  134
             + +DG+R  + +L+ E+ G+ RSL+T ER ALNFLQ LSG+A+    Y + +++ ++K+
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  135  LDTRKTIPGLRTAQKYAVTCGGCHNHRIGLYDAFLIKENHIMACGGIQQAIASAHTIAP-  193
            +DTRKT P LR  +KYAV  GG  NHR+ L DA+++K+NHI A G++Q+AIA A++ AP 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  194  GKPVEIEVETLEEFQAALDAGADIIMLDEFDKPQTIEAVNLRNNRRPATKIEASGGISKD  253
             K VE+EVE+L   + A  AG DIIMLD+    Q  +A+ L   R   ++IE SG I   
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR---SRIECSGNIDMT  253

Query  254  NLGEIASWGADFISIGALTKHARAVDLSMRVIS  286
             ++ + + + D++S G+LT  A+++D+SM+ ++
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

496) Hden_2000 in NC_014313


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (541),  Expect = 8e-37, Method: Compositional matrix adjust.
 Identities = 96/216 (45%), Positives = 151/216 (70%), Gaps = 2/216 (0%)

Query  71   IEPETDF--TIEIGDGETVKPGAVIARVSGNARALLTAERVALNFLGRLSGIATLTRQYV  128
            +++E  F    ++ DG+ + +G ++  + G+ R+LLT ERVALNFL +LSGIA++T  YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  129  DQVAGTHAKIVDTRKTTPGLRAFEKYAVRCGGGYNHRVGLFDAVLIKDNHIVaaggiasa  188
            + +++ + K+ DTRKTTP LR FEKYAVR GGGYNHR  L DA+++KDNHI A G++  A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  189  ikaakaaagHMTKIEVEVDTLAQLEIVMREKVDCVLLDNMTPANLVEAVAIIGGRCLTEA  248
            I  A+A A  +  +EVEV++LA  E      VD ++LDNM+  ++ +A+++I+GR   E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  249  SGGVNLETVTEIAQTGVDLISVGALTHSASVLDLGL  284
            SG +++ T++ +   ++D +S G+LTHSA  LD+++
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

497) A11Q_1827 in NC_020813


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 8e-37, Method: Compositional matrix adjust.
 Identities = 109/268 (41%), Positives = 171/268 (64%), Gaps = 4/268 (1%)

Query  5    DLIKAALKEDMPSGDVTTESLAMKPKMGEALLKAKEDLVLSGANAFEETILFMEPQARVK  64
            D +KAAL+ED+ S D +T+++      +   L AKE  VL+G   F+  + + +++   +
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  65   --WQFNEGDLVYKGQNICSIEGDLLQVLKAERVALNFLGRLSGIATLTRKFVKEVEGTQT  122
               QF++GD +  G+ +  I G +  +L  ERVALNFL +LSGIA++T  +V  + + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  123  KILDTRKTTPLLRELEKRAVQHGGGLNHRFNLSDAILVKDNHITLMGGISKAVERIRQYS  182
            K++DTRKTTP LR +EK AV+ GGG NHRFNLSDAI++KDNHI+ +G++ KA+ + R Y+
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  183  KLP--LEVEASNLEQVRECVSLNVERILLDNMDNATLTMALELIPKTIRTEASGNMSLTR  240
             +   +EVE  +L    E  +  V+ I+LDNM    +  A+ LI+   R E SGN+ +T 
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  241  VKSVAQLGVDFISVGALTHSAPTADVSL  268
            +     L++D++S G+LTHSA + D S+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

498) nadC in NC_007776


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 9e-37, Method: Compositional matrix adjust.
 Identities = 123/280 (44%), Positives = 190/280 (68%), Gaps = 10/280 (3%)

Query  5    YLPEETLCAWLWEDLGHGDltteltlppglegeAVILAKETGILAGLEIAKRVFRLADPQ  64
            +  ++TL A L+ED+   D +T+  +    ++   ++AKE+G+LAGL + +RVF L D++
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  65   VEFIPGVE--EGARVAVRQEVAHLKGSLKGILAGERLALNLLQRLSGIATLTRTYVEALR  122
            V F    +  +G R++  + V ++ GS++++L+ ER+ALN+LQ+LSGIA++T +YVEAL 
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  123  GTSTQLLDTRKTTPGLRALEKYAVRVGGGKNHRFGLFDGILIKENHIIATQRCCDRGAGG  182
            +   +++DTRKTTP LR +EKYAVRVGGG NHRF L D+I++K+NHI A         G+
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV--------GS  182

Query  183  VLAAVKRAKEGAPHHLKVEVEVRdlqeleealaagadlilldNFTLEETQAAVQRVGGRV  242
            V  A+ +A+  AP    VEVEV  L   EEA AAG D+I+LDN +LE+ + A+  ++GR 
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  243  PLEASGNMTPERARQVAEAGVNYVSVGALTHSAKALDLSL  282
             +E SGN+      +    +++YVS G+LTHSAK+LD+S+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

499) Clim_2139 in NC_010803


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 9e-37, Method: Compositional matrix adjust.
 Identities = 114/272 (42%), Positives = 176/272 (65%), Gaps = 12/272 (4%)

Query  20   ALEEDRYTGDITTLATIRQGQQGCAVIKAKAEGVLAGASVAEEVFKACDPGLTIV----F  75
            AL ED  + D +T A + +  Q+   + AK  GVLAG +V + VF   D+ +T+     F
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  76   LRNDGDHIRMGDTVLEVSGGIASLLMAERTVLNFMQRMSGIATRTNTYVNKISHTGTAIL  135
              +DGD++  GD VLE+ G++ SLL  ER  LNF+Q++SGIA+ T +YV+ +++    ++
Sbjct  80   --KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  136  DTRKTVPGLRYFDKEAVRIGGGKNHRFGLFDMILIKDNHIDACGGVGNAVREAVAYRKNN  195
            DTRKT P LR F+K AVR+GGG NHRF L D I++KDNHI A G+V +A+ +A AY    
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY---A  194

Query  196  GLDVQIETEVRSLEELAEALPCGPDIVLLDNLSVDMLQQAVAFARAEAPSVKLEASGNVG  255
             +   +E EV SL    EA + G DI++LDN+S++ ++QA+++    A   ++E SGN++
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNID  251

Query  256  LHNVAAIAETGVDYISIGELTHSVTALDLSMT  287
            +  ++ +   ++DY+S G LTHS  +LD+SM 
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

500) nadC in NC_015602


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 9e-37, Method: Compositional matrix adjust.
 Identities = 99/237 (42%), Positives = 167/237 (71%), Gaps = 3/237 (1%)

Query  37   SFIAKQSGIICGQEIPQATYDLL-GHATYK--PRIPDGTPVKAGDIIGTVSGTAQTLLSG  93
            S++AK++G++ G  + Q  + L+ ++ T++   ++ DG  + +GD++  + G+ ++LL+ 
Sbjct  45   SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTC  104

Query  94   ERVTLNLIQRMSGIATQTTHFVKLLDDATIRITDTRKTAPGLRLFDKYAVSVGGGFNHRF  153
            ERV+LN++Q++SGIA+ T+ +V  L+D  I++ DTRKT+P LRLF+KYAV VGGG+NHRF
Sbjct  105  ERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRF  164

Query  154  DLTGGIMLKDNHIALAGGVTQALAAVKRHVGPLNPveveveteeeLRQAVAGGANVIMFD  213
            +L+++IMLKDNHIA  G+V +A+A  +     ++ VEVEVE+     +A A+G ++IM+D
Sbjct  165  NLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  214  NQNPETIKQWRQLVPKTIKVEASGGITAESISTFKGCGADFISIGNLTNDVTPLDIS  270
            N + E I Q   L++   ++E SG I   +IS F+G + D++S G+LT+   +LD+S
Sbjct  225  NMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

501) BDI_2086 in NC_009615


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 9e-37, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 179/278 (65%), Gaps = 10/278 (3%)

Query  5    IDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGVLAGVEMAKRIFHDFDPELK  64
            IDD +K A+ ED+   D +T   + + + +K  L+ KE GVLAG+ + +R+F  FD+E+ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  65   MTV---FIQDGAEVKKGDIAFVVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKALEG  121
                  F +DG  +  GD+ + + G ++SLL  ER+ LN +Q++SGIA+ T  Y  AL +
Sbjct  73   FQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  122  TKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMILLKDNHVDFAGGIEQAITRAQ  181
             +  V+DTRKTTP +R++EK AVR+GGG NHR+ L D I+LKDNH+   G++++AI++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  182  NYLKEKGKNLK-IEIEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVES  240
             Y    +  +K +E+EV ++    +    +G+D IMLDN ++E+  +A+  I GR  +E 
Sbjct  192  AY----APFVKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  241  SGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKA  278
            SG I   T+  +   ++D++S G+LTHS KSLD S K+
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

502) Bpro_0902 in NC_007948


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  147 bits (540),  Expect = 9e-37, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 180/264 (69%), Gaps = 3/264 (1%)

Query  23   ALAEDVGAGDL-TAGLIDPARSARAQVLARESAVICGSAWVEATILQLDPQARL--TWHV  79
            AL EDV + D  T +++D    A+  ++A+E++V+ G +  +  +  +D++  +    + 
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  80   RDGERCAANQVVLEIQGRAQALLTAERTALNFLQLLSAVASKTAGYVAAVQGTRAQIVDT  139
            +DG+R ++ ++VLEI G  ++LLT ER ALNFLQ LS++AS TA+YV A+ + R ++ DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  140  RKTLPGLRLAQKYAVRTGGGTNHRIGLYDAVLIKENHiaaaggiaqvlaraaavaaqaDF  199
            RKT P LRL +KYAVR GGG NHR+ L DA+++K+NHIAA G++ + +A+A A A+    
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  200  VQIEVEDLAELQQALNAGARMVLLDNMTLDQLREAVRINEGRASLEISGGVTQESLRSLA  259
            V++EVE LA  ++A  AG  +++LDNM+L+Q+ +A+ +  GR+ +E SG +   ++  + 
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  260  ETGVDRISIGGLTKDVKAIDFSMR  283
              ++D +S G+LT   K++DFSM+
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

503) nadC in NC_012438


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (538),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 116/238 (49%), Positives = 172/238 (73%), Gaps = 7/238 (2%)

Query  41   AKQSGVVAG-TVFVKEVFNVF-GDVSFQSFK--KEGDYIEKGEIIGLVYGNCKSILKGER  96
            AK++GV+AG TVF + VF +F ++V+FQ+    K+GD +  G+++  + G+ +S+L  ER
Sbjct  48   AKEAGVLAGLTVFQR-VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCER  106

Query  97   VALNILQRLSGIATLTNLFIKELEGtktklldtrkttPGFRAFEKYAVKVGGGENHRFAL  156
            VALN+LQ+LSGIA++T  ++  L + + K++DTRKTTP +R FEKYAV+VGGG NHRF L
Sbjct  107  VALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNL  166

Query  157  YDMVMLKDNHIALVGSIKEAVKQVKSKVSPIVK-VEVEVSNFDQLYEALETEADIIMLDN  215
             D +MLKDNHIA VGS++ A+ Q ++  +P+VK VEVEV ++    EA  +  DIIMLDN
Sbjct  167  SDAIMLKDNHIAAVGSVQKAIAQARA-YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  216  MTPTQVKEAVEIINGKKLVEVSGNITLENIKQYALSNPDFVSTGSVIHSAKWLDISLK  273
            M+  Q+ +A+ +I G+  +E SGNI +  I ++     D+VS+GS+ HSAK LD+S+K
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

504) SL003B_3339 in NC_015259


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (539),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 131/283 (47%), Positives = 197/283 (70%), Gaps = 3/283 (1%)

Query  1    MTALLPELPRLLVEDAVKAALLEDWGRAGDITSQATIPATAQARAVIAGRKPgvlagldl  60
            M+ +  +L  + ++D++KAAL ED  ++ D +++A +   +QA+  + ++ +GVLAGL +
Sbjct  1    MSIISTDLTPFQIDDTLKAALRED-VHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  61   avaafalTDPAVSVE--RMLTDGARLGRGDVVARIEGPARAILSAERVALNFLGHLSGIa  118
                F+L D+ V+ +  + + DG RL  GD+V  I G+ R++L+ ERVALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  119  tataafaeriahtRAKIVCTRKTTPGLRSLEKYAVRCGGGANHRFGLDDAILIKDNHvav  178
            + TAA+ E +++ R K+  TRKTTP LR +EKYAVR GGG NHRF L DAI++KDNH+A 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  179  aggvrpaiaaarafagHLVKIEVEVDTLDQLAEALEAGPDVIMLDNMSPETMRRAVALTA  238
             G+V+ AIA ARA+A  +  +EVEV++L    EA  AG D+IMLDNMS E + +A++L A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  239  GRAVLEASGGIELDTAAAVAETGVDLLSSGWITHSAPVLDLGL  281
            GR+ +E SG I++ T +     ++D +SSG +THSA  LD+++
Sbjct  240  GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

505) B2K_35905 in NC_017672


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (539),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 122/279 (44%), Positives = 189/279 (68%), Gaps = 5/279 (1%)

Query  3    ELTGSQLEQSLRLWLEEDIGMGDVTTMTTISADSTAKGIIHVKDAGIVAGLPVAQAVFAM  62
            +LT  Q++++L+  L ED+   D +T + +  ++ AK  +  K+AG++AGL V Q VF++
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  63   VDPSLRFEA--KAAEGQQVEYGTVLAEVTGSTRSILLGERLALNLLQRMSGIATRTRQYV  120
             D+ + F+   +  +G+++  G ++ E+ GS RS+L  ER+ALN+LQ++SGIA+ T  YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  121  DRLEGLPTRLVDTRKTTPGHRMLEKYAVRVGGGYNHRFGLYDAVMIKDNHikgaggiaka  180
            + L +   ++ DTRKTTP  R++EKYAVRVGGGYNHRF L DA+M+KDNHI + G++ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  181  iqaaraqiPHTMKIevevenfeqleeALGARPDIVMLDNMSTEQMKQAVQRMKQEAPHIM  240
            I  ARA  P    +EVEVE++   EEA +A  DI+MLDNMS EQ+ QA+  +   A +  
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSR  243

Query  241  IEASGSVTLNTLRGIAETGVDVISVGRLTYSVQALDISL  279
            IE SG++ + T+  +   ++D +S G LT S ++LD+S+
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

506) STHERM_c10350 in NC_014484


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (539),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 111/256 (44%), Positives = 172/256 (68%), Gaps = 7/256 (2%)

Query  35   TSKAVFPPEAEGAARVVSKGEGILAGDFVFERVFRKINERISVSFLRQ--DGDVLSRGDV  92
            +++A+F  ++++   + +K  G+LAG  VF+RVF  ++  ++    +Q  DGD L+ GD+
Sbjct  31   STNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDL  90

Query  93   VAELSGPMADLLTGERIALNFLAFLSGIATYTSKFVKEAGKSGHTVILDTRKTLPGFRRL  152
            V E+ G++  LLT ER+ALNFL  LSGIA+ T+ +V   G  ++  ++DTRKT P +R +
Sbjct  91   VLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG-DDRIKVFDTRKTTPNLRLF  149

Query  153  SKYAVRIGGGENHRMGLYDMVLIKDNHIDGAGSITKAVERVRERWGDRF--KIevecrtv  210
             KYAVR+GGG NHR  L D +++KDNHI + GS+ KA+ + R      F   +EVE  ++
Sbjct  150  EKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY--APFVKMVEVEVESL  207

Query  211  eeveeALGAGVHIIMLDNMSPSEMEESIRRGRGKVLFECSGDMDLPKIAEVSKLGVDYIS  270
               EEA +AGV+IIMLDNMS  ++E++I    G+  +ECSG++D+  I+    L++DY+S
Sbjct  208  AAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVS  267

Query  271  VGRITHSAPAFDFSMK  286
             G +THSA ++DFSMK
Sbjct  268  SGSLTHSAKSLDFSMK  283

507) nadC in NC_005085


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (538),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 111/276 (41%), Positives = 183/276 (67%), Gaps = 5/276 (1%)

Query  5    APHLIAQQVALALAEDIGPCDRTAQLIAADKAGSARV--IAREDAVICGQAWFDECFRQV  62
            +P  I + +  AL ED+ + D +++ I  D  G A+V  +A+E +V+ G + F+  F   
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIF-DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  63   DARCRVE--WLAAEGEKVAAGRELCRISGPARALLTAERSALNFLQLLSGVASETRRYVD  120
            DA    +      +G+++++G  +  I G+ R+LLT ER ALNFLQ LSG+AS T  YV+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  121  AVAGHRARILDTRKTLPGLRLAQKYAVTAGGGDNQRIGLFDGILIKENHIMAAGGVAQAM  180
            A++++R +++DTRKT P LRL +KYAV  GGG N+R+ L D+I++K+NHI A G+V +A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  181  EQALADLPPGVTLQIEVENLAQLEEALNHGARLVLLDNMSLDDMRRAVEICAGRAELEAS  240
             QA A  P    +++EVE+LA  EEA   G  +++LDNMSL+++ +A+ + AGR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  241  GGVDLDSVRAIAATGVDRISVGKLTKDVRALDLSMR  276
            G +D+ ++  + + ++D +S G LT   ++LD+SM+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

508) XF1925 in NC_002488


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (538),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 114/283 (41%), Positives = 187/283 (67%), Gaps = 5/283 (1%)

Query  1    MNLIS--LPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQSGVIAGLDT  58
            M++IS  L  + I+  ++ AL ED+  + D ++ A++ +  ++ V + A+++GV+AGL  
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTV  59

Query  59   AELAFKVINAELVMM--RHVHDGMKVKPGDVIATITGCSRALLTAERTALNFLSHLsgia  116
             +  F +++AE+     ++  DG ++ +GD++  I G  R+LLT ER ALNFL HLSGIA
Sbjct  60   FQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIA  119

Query  117  tatasivtaiagtKTVVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAI  176
            + TA+ V A+++ +  V  TRKT P +R ++KYAVR GGG NHRF L DA+++KDNHIA 
Sbjct  120  SMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAA  179

Query  177  AGSVREALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVA  236
             GSV+ A+ +A+A A  +  +E+EV++L   +EA   GVD ++LDNM   ++ +A+ ++A
Sbjct  180  VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA  239

Query  237  GRAITEASGRITPETAINIAASGVDLISVGWITHSAPILDIGL  279
            GR+  E SG I   T   + + ++D +S G +THSA  LD+++
Sbjct  240  GRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

509) XFLM_10055 in NC_017562


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (539),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 113/277 (41%), Positives = 182/277 (66%), Gaps = 3/277 (1%)

Query  5    SLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAELAFQ  64
             L  + I+  ++ AL ED+  + D ++ A++ +  ++ V + A++AGV+AGL + +  F 
Sbjct  7    DLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   LIDAELVMM--RHVHDGMKVEPGDVIATITGCSRALLTAERTALNFLSHLsgiatatasi  122
            L+DAE+     ++  DG ++ +GD++  I G  R+LLT ER ALNFL HLSGIA+ TA+ 
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ataiagtktiVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSVRE  182
              A+++ +  V  TRKT P +R ++KYAVR GGG NHRF L DA+++KDNHIA  GSV+ 
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  ALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAITE  242
            A+ +A+A A  +  +E+EV++L   +EA   GVD ++LDNM   ++ +A+ ++AGR+  E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  243  ASGRITPETAINIAASGVDLISVGWITHSAPILDIGL  279
             SG I   T   + + ++D +S G +THSA  LD+++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

510) Xfasm12_1043 in NC_010513


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (538),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 112/277 (41%), Positives = 182/277 (66%), Gaps = 3/277 (1%)

Query  5    SLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQSGVIAGLDMAELAFQ  64
             L  + I+  ++ AL ED+  + D ++ A++ +  ++ V + A+++GV+AGL + +  F 
Sbjct  7    DLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   LIDAELVMM--RHVHDGMKVEPGDVIATITGCSRALLTAERTALNFLSHLsgiatatasi  122
            L+DAE+     ++  DG ++ +GD++  I G  R+LLT ER ALNFL HLSGIA+ TA+ 
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ataiagtktiVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSVRE  182
              A+++ +  V  TRKT P +R ++KYAVR GGG NHRF L DA+++KDNHIA  GSV+ 
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  ALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAITE  242
            A+ +A+A A  +  +E+EV++L   +EA   GVD ++LDNM   ++ +A+ ++AGR+  E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  243  ASGRITPETAINIAASGVDLISVGWITHSAPILDIGL  279
             SG I   T   + + ++D +S G +THSA  LD+++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

511) XfasM23_0920 in NC_010577


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (539),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 113/277 (41%), Positives = 182/277 (66%), Gaps = 3/277 (1%)

Query  5    SLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAELAFQ  64
             L  + I+  ++ AL ED+  + D ++ A++ +  ++ V + A++AGV+AGL + +  F 
Sbjct  7    DLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   LIDAELVMM--RHVHDGMKVEPGDVIATITGCSRALLTAERTALNFLSHLsgiatatasi  122
            L+DAE+     ++  DG ++ +GD++  I G  R+LLT ER ALNFL HLSGIA+ TA+ 
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ataiagtktiVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSVRE  182
              A+++ +  V  TRKT P +R ++KYAVR GGG NHRF L DA+++KDNHIA  GSV+ 
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  ALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAITE  242
            A+ +A+A A  +  +E+EV++L   +EA   GVD ++LDNM   ++ +A+ ++AGR+  E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  243  ASGRITPETAINIAASGVDLISVGWITHSAPILDIGL  279
             SG I   T   + + ++D +S G +THSA  LD+++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

512) nadC in NC_004556


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (539),  Expect = 1e-36, Method: Compositional matrix adjust.
 Identities = 113/277 (41%), Positives = 182/277 (66%), Gaps = 3/277 (1%)

Query  5    SLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAELAFQ  64
             L  + I+  ++ AL ED+  + D ++ A++ +  ++ V + A++AGV+AGL + +  F 
Sbjct  7    DLTPFQIDDTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   LIDAELVMM--RHVHDGMKVEPGDVIATITGCSRALLTAERTALNFLSHLsgiatatasi  122
            L+DAE+     ++  DG ++ +GD++  I G  R+LLT ER ALNFL HLSGIA+ TA+ 
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ataiagtktiVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSVRE  182
              A+++ +  V  TRKT P +R ++KYAVR GGG NHRF L DA+++KDNHIA  GSV+ 
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  ALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAITE  242
            A+ +A+A A  +  +E+EV++L   +EA   GVD ++LDNM   ++ +A+ ++AGR+  E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  243  ASGRITPETAINIAASGVDLISVGWITHSAPILDIGL  279
             SG I   T   + + ++D +S G +THSA  LD+++
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

513) PM3016_7118 in NC_016935


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (537),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 122/279 (44%), Positives = 189/279 (68%), Gaps = 5/279 (1%)

Query  3    ELTGSQLEQSLRLWLEEDIGMGDVTTMTTISADSTAKGIIHVKDAGIVAGLPVAQAVFAM  62
            +LT  Q++++L+  L ED+   D +T + +  ++ AK  +  K+AG++AGL V Q VF++
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  63   VDPSLRFEA--KAAEGQQVEYGTVLAEVTGSTRSILLGERLALNLLQRMSGIATRTRQYV  120
             D+ + F+   +  +G+++  G ++ E+ GS RS+L  ER+ALN+LQ++SGIA+ T  YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  121  DRLEGLPTRLVDTRKTTPGHRMLEKYAVRVGGGYNHRFGLYDAVMIKDNHikgaggiaka  180
            + L +   ++ DTRKTTP  R++EKYAVRVGGGYNHRF L DA+M+KDNHI + G++ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  181  iqaaraqiPHTMKIevevenfeqleeALGARPDIVMLDNMSTEQMKQAVQRMKQEAPHIM  240
            I  ARA  P    +EVEVE++   EEA +A  DI+MLDNMS EQ+ QA+  +   A +  
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSR  243

Query  241  IEASGSVTLDTLRGIAETGVDVISVGRLTYSVQALDISL  279
            IE SG++ + T+  +   ++D +S G LT S ++LD+S+
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

514) KNP414_07574 in NC_015690


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (537),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 122/279 (44%), Positives = 189/279 (68%), Gaps = 5/279 (1%)

Query  3    ELTGSQLEQSLRLWLEEDIGMGDVTTMTTISADSTAKGIIHVKDAGIVAGLPVAQAVFAM  62
            +LT  Q++++L+  L ED+   D +T + +  ++ AK  +  K+AG++AGL V Q VF++
Sbjct  7    DLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  63   VDPSLRFEA--KAAEGQQVEYGTVLAEVTGSTRSILLGERLALNLLQRMSGIATRTRQYV  120
             D+ + F+   +  +G+++  G ++ E+ GS RS+L  ER+ALN+LQ++SGIA+ T  YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  121  DRLEGLPTRLVDTRKTTPGHRMLEKYAVRVGGGYNHRFGLYDAVMIKDNHikgaggiaka  180
            + L +   ++ DTRKTTP  R++EKYAVRVGGGYNHRF L DA+M+KDNHI + G++ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  181  iqaaraqiPHTMKIevevenfeqleeALGARPDIVMLDNMSTEQMKQAVQRMKQEAPHIM  240
            I  ARA  P    +EVEVE++   EEA +A  DI+MLDNMS EQ+ QA+  +   A +  
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSR  243

Query  241  IEASGSVTLDTLRGIAETGVDVISVGRLTYSVQALDISL  279
            IE SG++ + T+  +   ++D +S G LT S ++LD+S+
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

515) C380_19015 in NC_018708


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (537),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 92/214 (43%), Positives = 147/214 (69%), Gaps = 0/214 (0%)

Query  64   DPTVQITWHVAEGQRCAPDQVVLELEGQARALLSAERTALNFLQLLSAVATKTRTYVDVV  123
            + T Q   +  +G+R +++++VLE+ G  R+LL+ ER ALNFLQ LS++A+ T +YV+ +
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  124  AGTRAQIVDTRKTLPGLRLAQKYAVRVGGGTNHRIGLHDAVLIKENHIAAAGSVTavlra  183
            ++ R ++ DTRKT P LRL +KYAVRVGGG NHR+ L DA+++K+NHIAA GSV   +  
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  184  aqavaaqaTFIEIEVETLEQLTEALNAGAKMVLLDNIPLPMLREAVRINAGRAILEISGG  243
            A+A A+    +E+EVE+L    EA  AG  +++LDN++L  + +A+ + AGR+ +E SG 
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  244  VTLEGLRELAETGVDRISIGTLTKDVKATDFSMR  277
            + +  +  +   ++D +S G+LT   K+ DFSM+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

516) nadC in NC_010170


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  146 bits (537),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 112/268 (42%), Positives = 179/268 (67%), Gaps = 3/268 (1%)

Query  24   RAALLEDLGRAGDLTTDAIVPNDAQARTRLVARQEGVLAGLDLARLAFQLMDAGIEFRPV  83
            +AAL ED+ ++ D +T+AI  +++QA+  L A++ GVLAGL + +  F L DA + F+  
Sbjct  18   KAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  84   --LADGARLRPGSEIAVISGPARGMLTAERTALNFLGHLSGVATATASIADAIRPHGARV  141
              + DG RL +G  +  I G+ R++LT ER ALNFL HLSG+A+ TA+  +A+  +  +V
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  142  TCTRKTLPGLRAVQKYAVRVGGGSNHRHGLDDAVLIKDNHvavaggvrqavqraragIGH  201
              TRKT P LR  +KYAVRVGGG NHR  L DA+++KDNH+A  G+V++A+ +ARA    
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  202  MVKIELEVDTLEQLDQALEIGVDVVLLDNMDLPTLREavrrvggravTEASGRITPESAP  261
            +  +E+EV++L   ++A   GVD+++LDNM L  + +A+  ++GR+  E SG I   + +
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  262  EVAATGVDLIAVGWLTHSARVLDIGLDS  289
               + ++D ++ G LTHSA+ LD+++ +
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

517) Tery_4352 in NC_008312


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 121/276 (44%), Positives = 180/276 (66%), Gaps = 7/276 (2%)

Query  11   LDNLLKDWLLEDIGRGDRTTSGLLLEDEVIVGTGHWLIKEPGVIAGLPIAARVFELLDQQ  70
            +D+ LK  L ED+   D +T++++  D+   +    + KE+GV+AGL +  RVF L+D +
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIF--DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  71   VNFLPT--VAEGEWCEKGTVVAKLDGSLDSLLTGERVALNLGMRLSGIATMTRKYVEKIA  128
            V F       +G++   G +V  + GS+ SLLT ERVALN+  +LSGIA+MT  YVE ++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  129  GLPVQLVDTRKTTPGLRILEKYATQVGGAKNHRMGLDDGVMIKDNHiaaaggigeaiaKV  188
            +  +++ DTRKTTP LR++EKYA +VGG+ NHR  L D++M+KDNHIAA G++  AIA+ 
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  189  RERIPYPltievetetlveveraleHQADIIMLDNMSVEVMEQAVKMIRQNNSRIKIEAS  248
            R   P+   +EVE E+L   E A     DIIMLDNMS+E +EQA+ +I    +R +IE S
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECS  247

Query  249  GNITLETIRNVAETGVDYISTSAPITRSTWLDLSMK  284
            GNI + TI      ++DY+S+++    +  LD+SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

518) nadC in NC_020547


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 116/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENHIMaaggiakaiakaHQ  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ KAIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  IAP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

519) ABTJ_03769 in NC_017847


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 116/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENHIMaaggiakaiakaHQ  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ KAIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  IAP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

520) Pmen_0778 in NC_009439


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 194/278 (70%), Gaps = 5/278 (1%)

Query  7    ADLSS-EIEANVRRALAEDIGSGDITAQLIPAER-LASARVITREAAVVCGTAWVDAVFR  64
            +DL++ +I+  ++ AL ED+ S D +++ I  ++  A   ++++EA+V+ G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVQDGDKVSADQTLFRLEGPARALLSGERSALNFLQTLSAVATRCRHY  122
             +D+ V+ +   Q +DGD++++++ ++ + G+ R+LL+ ER ALNFLQ LS++A+    Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVEGTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIAQ  182
             + + + ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AINTAHQIAP-GKPvevevesleelrealeagaDIVMLDELSLEDMREAVRLTAGRTKLE  241
            AI  A+  AP  K VEVEVESL    EA  AG DI+MLD++SLE++ +A+ L AGR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINDSTLRVIAETGVDYISLGTLTKDVKAVDLSMR  279
             SG I+ +T+  +   ++DY+S G+LT   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

521) nadC in NC_003909


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (534),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 110/274 (41%), Positives = 182/274 (67%), Gaps = 2/274 (0%)

Query  1    MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFAGRLVIEEGFKLI  60
            +  +++ ++L+  + ED+   D +++ IF ++  +K +++AK++GV+AG  V++  F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DERIEVELHK--KDGDLVEKGEIIATVQGPIASLLTAERVILNIIQRMSGIATMTYEAVR  118
            D  +  +     KDGD +  G+++  + G++ SLLT ERV LN++Q++SGIA+MT   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  ALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAV  178
            AL+  + ++ DTRKT P LR+F+KYAV  GGG+NHRF L D++M+KDNHIA  GS+ KA+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  TSVKEKVGHMvkveveteteeqvreavaaGADIIMFDNRTPDEIREFSKIVPSAIVTEAS  238
            +  +     +  VEVE E+     EA AAG DIIM+DN + ++I +   ++++    E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGITIEGLSKYGKTGVDYISLGSLTHSVKALDIS  272
            G I +  +S++   ++DY+S GSLTHS K+LD+S
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

522) nadC in NC_008027


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 194/278 (70%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERATANQALFHLEGPARSLLSGERSALNFLQMLSGVATRARLL  122
             +D+ V+ +   Q  DG+R T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVEGTQVRLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIaasggvaq  182
             + + + +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIVMLDELTLDEMREAVRINDGKAKLE  241
            A+A A+  AP  K VE+EVESL    +A AAG DI+MLD+++L+++ +A+ +  G++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGSMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S GS+T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

523) Psest_0718 in NC_019936


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 192/278 (70%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALTEDVGSGDITAQLIPAER-LAHASVITRETAVVSGTAWVDAVFR  64
            +DLT+ +I+  ++ AL EDV S D +++ I  ++  A  S++++E++V++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QVDSRVAVH--WQVADGERVEADRVLFHLEGPARALLTGERSALNFLQMLSGVATRCRHY  122
              D+ V+ +   Q  DG+R+ ++ +++++ G+ R+LLT ER ALNFLQ LSG+A+    Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADMVSGTGVRLLDTRKTIPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaacggiae  182
             + +++  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaahriaP-GKPVEIEVESLDELEQALRAGADIVMLDELTLDDMRTAVAMTAGRAKLE  241
            A+A A+  AP  K VE+EVESL   E+A  AG DI+MLD+++L+++  A+++ AGR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGISDETLRSVAETGVDYISIGALTKHVRAVDLSMR  279
             SG I   T+      ++DY+S G+LT   +++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

524) nadC in NC_019673


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (535),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 114/280 (41%), Positives = 180/280 (65%), Gaps = 19/280 (6%)

Query  14   TALAEDLRYGPDATTEATVPADAVAVAELTPRAAGVLAGIPV---ALAVFEEVLDFEVLD  70
            +AL ED++ + D +T+A    ++ A   L ++ AGVLAG+ V    +++F+  + F+  +
Sbjct  19   AALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPH  77

Query  71   RREDGDKAVPGEPALVLRGPVRGLLTAERTALNLLCHLSGIATLTAAWVDELAGTGARVR  130
            +  DGD+  +G+  L + G+VR+LLT ER ALN+L HLSGIA++TAA V+ L++   +V 
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  131  DSRKTLPGLRLLEKYAVRCGGGVNHRLGLGDAVLIKDNHVQAAGSVTAALRAVRAHAPDL  190
            D+RKT P LRL+EKYAVR GGG NHR+ L+DA+++KDNH+ A GSV  A+   RA AP +
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  191  P-CEVEVDSLAQLDEAVAEGAELVLLDNFTVAECAEAvrrvgglerggmeregvgrggvr  249
               EVEV+SLA  +EA A G ++++LDN ++ +  +A                +  G  R
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQA--------------ITLIAGRSR  243

Query  250  leASGGLTLAVARAYAETGVDYLAVGGLTHSAPALDLGMD  289
            +E SG + ++    +   ++DY++ G+LTHSA +LD++M 
Sbjct  244  IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

525) Bcep18194_A5837 in NC_007510


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (534),  Expect = 3e-36, Method: Compositional matrix adjust.
 Identities = 97/230 (43%), Positives = 159/230 (70%), Gaps = 3/230 (1%)

Query  65   LCGVPWFEAVIARIDPEIVVQ--WHYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQ  122
            L G+  F+ V++ +D+E+  Q   ++++GDR+T++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  123  LLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  182
             LSG+A+ T  YV+ + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  183  ENHIAAAGGVGEALDAAFALESGVP-VQVEVETLAQLDTALAHRAQSVLLDNFTLDMMRE  241
            +NHIAA G+V  A+  A A  + V  V+VEVE+LA  + A A   + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  242  AVRVAADKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMR  291
            A+ + A+++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

526) nadC in NC_015311


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (534),  Expect = 3e-36, Method: Compositional matrix adjust.
 Identities = 109/272 (41%), Positives = 178/272 (66%), Gaps = 10/272 (3%)

Query  15   AFSEDIGDGDHTTLCCIPADAMGESRLLIKEEGILAGVEIAKKVFHHFDPEL---HVEVY  71
            A+ ED+   D +T   +  ++ +   L+ KE G+LAG+ + ++VF  FD+E+   + + +
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  72   MEDGSHVKPGDIALSVKGRERSLLQTERLMLNIMQRMSGIATMTHRYQQALIDAGTKTRV  131
              DG ++ +GD+ L + G  RSLL  ER+ LN++Q++SGIA+MT  Y +AL  ++ + +V
Sbjct  80   -KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKV  136

Query  132  LDTRKTTPGMRMLEKEAVKIGGGMNHRIGLFDMILLKDNHIDFCGGIHNAISRAKQYCKE  191
            +DTRKTTP +R++EK AV++GGG NHR+ L D I+LKDNHI   G++++AI++A+ Y   
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA-P  195

Query  192  HGKEGLKIECEVRNFKELEEALAEGCDRIMFDNFTPEDTRKAVERVSGRCETESSGGITF  251
              K    +E EV ++   EEA A G D IM+DN + E+  +A+  ++GR   E SG I  
Sbjct  196  FVK---MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  252  ETMIPYAKAGVDFISFGALTHSVKGLDMSLKA  283
             T+  +   ++D++S G+LTHS K+LD S+K+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

527) Desal_1976 in NC_012881


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (532),  Expect = 4e-36, Method: Compositional matrix adjust.
 Identities = 108/269 (41%), Positives = 173/269 (65%), Gaps = 3/269 (1%)

Query  21   TIRIALSED--GPDLTSMGLFEQDDIATAQIIAKEDTVISGLPLINLILEFADQENKCQV  78
            T++ AL ED  + D ++ ++F++++ A   ++AKE  V++GL +++ ++ + D E   Q 
Sbjct  16   TLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  79   HLNVDEGDKISKGTLIAAIQGPAGLLLKAERVILNFISHMSGIATETRKYVDALDHSETI  138
              +  +GD+++ G L+  I G+   LL  ERV LNF+ H+SGIA+ T  YV+AL++    
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  139  LLDTRKTLPGLRYPEKYAVLCGGAKNHRLNLVEMLMLKDNHIDRAGSITAAVEKLRAKYG  198
            ++DTRKT P LR  EKYAV  GG+ NHR+NL + +MLKDNHI   GS+  A+ + RA Y+
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA-YA  194

Query  199  EDCPPIEVECRNQDEVDEAVATKVERIMLDNMTFDEAKAAIATIPDEIETEISGNVTLET  258
                 +EVE  +    +EA A+ V+ IMLDNM++++   AI+ I++    E SGN+ + T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  259  IAKLAEAGPDYISVGRITHSAKCSDMSMQ  287
            I+++   + DY+S G +THSAK  D SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

528) Ssed_0427 in NC_009831


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  145 bits (532),  Expect = 4e-36, Method: Compositional matrix adjust.
 Identities = 102/254 (41%), Positives = 171/254 (68%), Gaps = 15/254 (5%)

Query  47   AQATLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLLVPNQLLCELSGPARAI  104
            A+ +L+++E GV+ G +  ++VF  +++EV+++   +  DGD L + +L+ E+ G+ R++
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  105  LTGERTAMNFIQTLSGVATHTKHYIDKIADTHTKLLDTRKTIPGLRTAQKYAVTCGGGKN  164
            LT ER A+NF+Q LSG+A+ T  Y++ ++D + K++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  165  HRIGLFDAFLIKENHIMACGSISKAISAARALHP-DKPVEVEVESIQELQQALEARSDIV  223
            HR+ L DA+++K+NHI A GS+ KAI+ ARA  P  K VEVEVES+   ++A  A  DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  224  MLDNFDVTMMLEAVELNNQFFDQLNADKTASKTKLEVSGDVTLDTIANYAKTGVDYISVG  283
            MLDN  +  + +A+ L             A+++++E SG++ + TI+ +   ++DY+S G
Sbjct  222  MLDNMSLEQIEQAITL------------IAGRSRIECSGNIDMTTISRFRGLAIDYVSSG  269

Query  284  ALTKHVRALDLSLR  297
            +LT   ++LD+S++
Sbjct  270  SLTHSAKSLDFSMK  283

529) Taci_1755 in NC_013522


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (531),  Expect = 4e-36, Method: Compositional matrix adjust.
 Identities = 117/274 (43%), Positives = 178/274 (65%), Gaps = 2/274 (0%)

Query  8    IDPIIDQALREDMPYGDVSaaavlpepapavalvtaKAPGVVAGLLVGARTFQRLDPDAQ  67
            ID  +  ALRED+   D S+ A++ + + A   + AK +GV+AGL V  R F  +D++  
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   VE--LLARDGERVLPGRDVMRIRCDARALLSAERTALNLMQRMSGIATAVREFVDALRGY  125
             +     +DG+R+ +G  V+ I    R+LL+ ER ALN++Q++SGIA+    +V+AL + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  126  DTVVADTRKTAPGLRVLDKLAVLMGGGRNHRFGLSDGVMLKDNHIALAGGVAQAVHMARQ  185
               V DTRKT+P LR+++K AV +GGG NHRF LSD++MLKDNHIA  G+V +A+  AR 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  186  RVSHTMTIEVEAKTLEQVEEAVNAGADIIMLDNMPPEVMARAVQIARGRAIIEASGNMTV  245
              +    +EVE  +L   EEA  AG DIIMLDNM+ E + +A+ +  GR+ IE SGN+ +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  246  QRALEAARLGVQVVSVGSVTHSARALDLSLNVIS  279
                    L+++ VS GS+THSA++LD+S++ ++
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

530) nadC in NC_006576


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (531),  Expect = 4e-36, Method: Compositional matrix adjust.
 Identities = 117/283 (42%), Positives = 183/283 (65%), Gaps = 11/283 (3%)

Query  8    LPPWILLDPILSDWSREDLGRGDHSAQGLGLEGTTGKATWVAKSEGIIAGLPIAFRMLQL  67
            L P  + D  L    RED+   D S++++  +   +K +  AK  G++AGL +  R++ L
Sbjct  8    LTPFQI-DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL  66

Query  68   LDPQVKCTAKLAEGFACG----SGQVIAELEGPLASLLSGERAALNVAMRLSGVATATRR  123
            +D++V  T + ++ F  G    SG+++ E+ G++ SLL+ ER ALN   +LSG+A+ T  
Sbjct  67   FDAEV--TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  124  FVDQLADLPTQFVDTRKTTPGLRLLEKYATRVGGGTNHRLGLDDAVMVKDNHiaaaggsi  183
            +V+ L+D   +  DTRKTTP LRL+EKYA RVGGG NHR+ L DA+M+KDNHIAA G+  
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  184  aaaiKKLRSQLPFPLIIEVETETLGQVMEAISAGVGVIMLDNMNLAQVQAAVQVIRDRAP  243
             A  +  R+  PF  ++EVE E+L+   EA +AGV++IMLDNM+L Q++ A+ +I   A 
Sbjct  185  KAIAQA-RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AG  240

Query  244  RTKIEVSSNISLENIRAIAETGVDYISSSAPITRSPWLDISMR  286
            R++IE S+NI +  I  +   ++DY+SS++    +  LD+SM+
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

531) Bcen_1894 in NC_008060


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (531),  Expect = 5e-36, Method: Compositional matrix adjust.
 Identities = 96/230 (42%), Positives = 158/230 (69%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEGVIARIDSSIVVQ--WRYREGDRMTPDSIVCELEGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ +  Q   ++++GDR+T++ +V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YVE + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALESGVP-VQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A   + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMR  290
            A+ +  G++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

532) Bcen2424_2505 in NC_008542


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (531),  Expect = 5e-36, Method: Compositional matrix adjust.
 Identities = 96/230 (42%), Positives = 158/230 (69%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEGVIARIDSSIVVQ--WRYREGDRMTPDSIVCELEGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ +  Q   ++++GDR+T++ +V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YVE + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALESGVP-VQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A   + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMR  290
            A+ +  G++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

533) PCC7424_1213 in NC_011729


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (531),  Expect = 5e-36, Method: Compositional matrix adjust.
 Identities = 110/268 (42%), Positives = 182/268 (68%), Gaps = 6/268 (2%)

Query  19   LHEDLGRGDRTTGG-LNLQGRGKAIWVVKETGVIAGLPMAARVFQVLDEQMSF--IPRVK  75
            L+ED+   D +T + ++ +G++K     KE+GV+AGL +  RVF ++D +++F    + K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  76   EGEKCESGEIIAQmeglletllmgeRVALNIAMRLSGIATLTRQYTEVIADLPTQLVDTR  135
            +G++  SG+++ ++ G + +LL  ERVALN+  +LSGIA++T  Y E ++D   ++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  136  KTTPGLRIIEKYATQIGGAINHRMGLDDAVMIKDNHiqaaggieaaiaqiRQTIPYPLSI  195
            KTTP LR++EKYA ++GG+ NHR  L DA+M+KDNHI A G+++ AIAQ R   P+   +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  196  EVETTNLQEVEQALLSGADIIMLDNMTVDQMHEAVEFIHQHNDKIKIEASGNITLTNLRS  255
            EVE  +L   E+A  +G DIIMLDNM+++Q+++A+ +I    ++ +IE SGNI +T +  
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISR  257

Query  256  VALTGVDYISTSAPITRSSWLDLSMKIL  283
                ++DY+S+++    +  LD+SMK L
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

534) BCK_13045 in NC_018491


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (530),  Expect = 5e-36, Method: Compositional matrix adjust.
 Identities = 110/274 (41%), Positives = 181/274 (67%), Gaps = 2/274 (0%)

Query  1    MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFAGRLVIEEGFKLI  60
            +  +++ ++L+  + ED+   D +++ IF ++  +K +++AK++GV+AG  V++  F L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  61   DERIEVELHK--KDGDLVEKGEIIATVQGPIASLLTAERVILNVIQRMSGIATMTYEAVR  118
            D  +  +     KDGD +  G+++  + G++ SLLT ERV LN +Q++SGIA+MT   V 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  119  ALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAV  178
            AL+  + ++ DTRKT P LR+F+KYAV  GGG+NHRF L D++M+KDNHIA  GS+ KA+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  179  TSVKEKVGHMvkveveteteeqvreavaaGADIIMFDNRTPDEIREFSKIVPSAIVTEAS  238
            +  +     +  VEVE E+     EA AAG DIIM+DN + ++I +   ++++    E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  239  GGITIEDLSKYGKTGVDYISLGSLTHSVKALDIS  272
            G I +  +S++   ++DY+S GSLTHS K+LD+S
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

535) nadC in NC_014145


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (530),  Expect = 5e-36, Method: Compositional matrix adjust.
 Identities = 107/267 (41%), Positives = 181/267 (68%), Gaps = 3/267 (1%)

Query  12   VRRALEEDLGSGDL-TAALIDPQAVARATVRSREAARLCGTPWANACVRALDPAAHLEWL  70
            ++ AL ED+ S D  T A++D ++ A+ ++ ++EA+ L G    +     +D+   ++  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  71   AP--EGATLQADAVILEIRGNARALLSAERTMLNFLQLLSAVATRTAQYVDVVRGTRAQI  128
                +G  L ++ ++LEI G+ R+LL+ ER  LNFLQ LS++A+ TA YV+ + + R ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  129  VDTRKTLPGLRLAQKYAVRVGGGMNHRIGLFDAVLIKENHIAAAGGVaqalhraqavaaq  188
             DTRKT P LRL +KYAVRVGGG NHR+ L DA+++K+NHIAA G+V +A+ +A+A A+ 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  189  aqfiqIEVETLAQLDEALRAGARMVLLDNMSLDQLREAVRLTGQRAVLEVSGGVDLQTVR  248
             + +++EVE+LA  +EA  AG  +++LDNMSL+Q+ +A+ L + R+ +E SG +D+ T+ 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  249  AIAETGVDRISVGKLTKDVQAVDLSMR  275
             +   ++D +S G LT   +++D+SM+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

536) Bcenmc03_2530 in NC_010508


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (530),  Expect = 6e-36, Method: Compositional matrix adjust.
 Identities = 96/230 (42%), Positives = 158/230 (69%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEGVIARIDPSIAVQ--WRYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ ++ Q   ++++GDR+T++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YVE + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALESGVP-VQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A   + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMR  290
            A+ +  G++ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

537) Oter_0786 in NC_010571


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (529),  Expect = 6e-36, Method: Compositional matrix adjust.
 Identities = 107/256 (42%), Positives = 170/256 (67%), Gaps = 2/256 (0%)

Query  24   TSRAIFAPTHRSRGFISAGQDLVVCGLEVAARVFTRVDPALAVKLVA--RDGQRVKTGAK  81
            ++ AIF    +++  + A +  V+ GL V  RVFT  D+ ++ +     +DG+R+ +G  
Sbjct  31   STNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDL  90

Query  82   VLTVTGPTGALLTAERTALNFLQRLSGVATQARRFADAVEGTGVRVVDTRKTTPGWRALE  141
            VL + G+  +LLT ER ALNFLQ+LSG+A+ +  + +A+ +  ++V DTRKTTP  R +E
Sbjct  91   VLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFE  150

Query  142  KYAVRCGGCVNHRSSLGEHVLIKDNHIAAAGSLakavqlaraaaPHLAKIEVEAKTLAEV  201
            KYAVR GG  NHR +L++ +++KDNHIAA GS+ KA+  ARA AP +  +EVE  +LA  
Sbjct  151  KYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAA  210

Query  202  REALRAGAEVILLDNMTPDRVEAALALIGGCAVVEVSGGVRYETLRAYAQPGVDVISIGA  261
             EA  AG ++I+LDNM+ +++E A++LI+G + +E SG +   T+  +   ++D +S G+
Sbjct  211  EEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGS  270

Query  262  LTHSAPAADLSLTVLP  277
            LTHSA + D+S+  L 
Sbjct  271  LTHSAKSLDFSMKGLT  286

538) CE1115 in NC_004369


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (529),  Expect = 6e-36, Method: Compositional matrix adjust.
 Identities = 111/273 (41%), Positives = 185/273 (68%), Gaps = 7/273 (2%)

Query  8    DRIVAAALDEDAPWGDLTSETLVPESAIVRAHLVAREPGVFSGTCLLEAAFRLVDPEIRI  67
            D  + AAL ED    D +++++  + +  +  L A+E+GV++G  +++  F L D+E+ +
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  68   E--LQITDGEAFEPKSLG-AITGSarailraerialNFTQRMSGIATQTARYVEAVAGTG  124
            +   Q+ DG+ + +  L   I GS R++L  ER+ALNF Q++SGIA+ TA YVEA+++  
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  125  ARIVDTRKTTPGLRIIERQAVRDGGGHNHRTSLSDAVMVKDNHLASVLASGMTITEALLQ  184
             ++ DTRKTTP LR++E+ AVR GGG NHR +LSDA+M+KDNH+A+V +   +I++A   
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA---  190

Query  185  MKSRLPHTTHVEVEVDRLDQIEPVLAAGVDTIMLDNFTNEELREGIKMVAGRAIVEASGG  244
             ++  P    VEVEV+ L   E   AAGVD IMLDN + E++ ++I ++AGR+ +E SG 
Sbjct  191  -RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  245  VNLDTVADIARTGVDVISVGALTHSVRALDLGL  277
            +++ T++ +   ++D +S G+LTHS ++LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

539) Mahau_1141 in NC_015520


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (530),  Expect = 6e-36, Method: Compositional matrix adjust.
 Identities = 109/268 (41%), Positives = 177/268 (67%), Gaps = 12/268 (4%)

Query  18   LEEDLGWGDITTDLLVDLKVTAHAYIKAKESGVIAGLPVAEMVYNTLDPAIQFIPLVQ--  75
            L ED+   D +T+ + D    A   + AKE+GV+AGL V + V+  +D+ + F    Q  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  76   DGFFIDTQTVIAEVKGPMNPILKGERLCLNLLQRMSGIAT----YTRRLSD-MIKPYKAE  130
            DG  + +  ++ E+ G++ ++L  ER+ LN+LQ++SGIA+    Y   L+D  IK +   
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF---  137

Query  131  LTDTRKTAPGLRYFDRYAVAVGGGINHRYNLADAVLIKDNHIKLAGGVKAALSKVQSNLS  190
              DTRKT+P LR F++YAV VGGG NHR+NL+DA+++KDNHI   G+V+ A+++ ++  +
Sbjct  138  --DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  191  HTMKIEIEVEGLQQLQQAIECHADIILLDNMPLDMMRRAVEITAGRAILEASGNIDESNI  250
                +E+EVE+L   ++A     DII+LDNM+L+ + +A+ + AGR+ +E SGNID + I
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  251  ADVAATGIDIISSGALTHSVNALDISMR  278
            +   + +ID +SSG+LTHS ++LD+SM+
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

540) Plim_0194 in NC_014148


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (529),  Expect = 6e-36, Method: Compositional matrix adjust.
 Identities = 101/248 (41%), Positives = 162/248 (66%), Gaps = 10/248 (4%)

Query  44   ATVKIVSRQPGILAGLPIAQMIYQQMDASIQWEA---FAVDGDELTAGQVVAEVTGPVST  100
            A V + ++++G+LAGL + Q ++   DA +  +    F  DGD LT+G++V E+ G+V +
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRS  100

Query  101  LLTGERTVLNFVTHLSGIATLTHQFVELAQGTKAKILDTRKTLPGYRSLAKYAVRCGGGH  160
            LLT ER  LNF+ HLSGIA++T  +VE   + + K++DTRKT P  R + KYAVR GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  161  NHRMGLYDGILIKDNHLAAWKSSGSIAEAIEHVRAQMGANIDIEVEVDTLEQMVDAMRAK  220
            NHR  L D+I++KDNH+AA    GS+  AI + RA       +EVEV++L    +A  A 
Sbjct  161  NHRFNLSDAIMLKDNHIAA---VGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG  217

Query  221  PQIILLDNMTTRELTEAVAYRDQHAAEILLEASGGVNLTTVAAIAATGVDRISIGALTHS  280
             +II+LDNM+  ++ +A++    ++    +E SG +++TT++ + + ++D +S G+LTHS
Sbjct  218  VDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTISRFRGLAIDYVSSGSLTHS  274

Query  281  APQLDLAL  288
            A  LD+++
Sbjct  275  AKSLDFSM  282

541) nadC in NC_017861


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (529),  Expect = 6e-36, Method: Compositional matrix adjust.
 Identities = 111/271 (41%), Positives = 179/271 (67%), Gaps = 9/271 (3%)

Query  15   AFSEDIGDGDHTTLCCIPADAMGESKLLIKEEGIFAGVDIAKRVFHRFDPELVVEV--YI  72
            A+ ED+   D +T   +  ++ +   L+ KE G++AG+ + +RVF  FD+E+  +    +
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  73   EDGAHVKPGDIVMSVKGREQSLLQTERLMLNILQRMSGIATMTHKYQQALIDAGTKTRVL  132
             DG ++ +GD+V+ + G  +SLL  ER+ LN+LQ++SGIA+MT  Y +AL  ++ + +V+
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVF  137

Query  133  DTRKTTPGMRMLEKEAVHIGGGTNHRIGLFDMILLKDNHIDFCGGVHNAISRAKAYCR-E  191
            DTRKTTP +R++EK AV++GGG NHR+ L D I+LKDNHI   G+V++AI++A+AY    
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  192  KGKDLKIECEVRNFKELDEALAEGCDRIMFDNFTPEDTRKAVDIVAGRCETESSGGITYE  251
            K     +E EV ++   +EA A G D IM+DN + E+  +A+ ++AGR   E SG I   
Sbjct  198  K----MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  252  TMIPYAKAGVDFISFGALTHSVKGLDMSFKA  282
            T+  +   ++D++S G+LTHS K+LD S K+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

542) B479_04410 in NC_019905


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (528),  Expect = 7e-36, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 194/278 (70%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERATANQPLFHLEGPARSLLSGERSALNFLQMLSGVATRARFL  122
             +D+ V+ +   Q  DG+R T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVEGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvaa  182
             + + + +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIIMLDELTLEEMREAVRITAGKAKLE  241
            A+A A+  AP  K VE+EVESL    +A AAG DIIMLD+++LE++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

543) PPS_0840 in NC_015733


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (529),  Expect = 7e-36, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 194/278 (70%), Gaps = 5/278 (1%)

Query  11   ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  68
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  69   QLDPRVAVH--WQVADGERATANQPLFHLEGPARSLLSGERSALNFLQMLSGVATRARFL  126
             +D+ V+ +   Q  DG+R T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  127  ADLVEGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvaa  186
             + + + +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  187  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIIMLDELTLEEMREAVRITAGKAKLE  245
            A+A A+  AP  K VE+EVESL    +A AAG DIIMLD+++LE++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  246  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  283
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

544) nadC in NC_014803


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (528),  Expect = 7e-36, Method: Compositional matrix adjust.
 Identities = 103/252 (41%), Positives = 170/252 (68%), Gaps = 3/252 (1%)

Query  31   TAQLIPQAEQAHAKVITREDCIFCGKDLIIEVFKQVDPSVVVNIC--VNDGDFVSANSTL  88
            T  ++ +  QA   ++++E  ++ G  ++  VF   D+ V  +     +DGD +++   +
Sbjct  32   TNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLV  91

Query  89   FTASGSARAILTAERTALNFVQTLSGTATTTAHYVKELSGTSTQLLDTRKTIPGLRALQK  148
            +   GS R++LT ER ALNF+Q LSG A+ TA YV  L++   +++DTRKT P LR ++K
Sbjct  92   LEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEK  151

Query  149  YAVKCGGGANHRIGLFDAFLIKENHIAACGGINNAVTQAKLNHA-DKPIEVEVESFDELE  207
            YAV+ GGG NHR+ L DA+++K+NHIAA G++++A++QA+   +  K +EVEVES+   E
Sbjct  152  YAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAE  211

Query  208  LAINAGADIIMLDNFNPEQIRQAVSITNKRAKLEVSGNMTLETLKAYSQAGVDFISSGAL  267
             A  AG DIIMLDN + EQI QA+++   R+++E SGN+ + T+  +   ++D++SSG+L
Sbjct  212  EAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSL  271

Query  268  TKNLQSIDLSMR  279
            T + +S+D+SM+
Sbjct  272  THSAKSLDFSMK  283

545) Bcep1808_2583 in NC_009256


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (528),  Expect = 8e-36, Method: Compositional matrix adjust.
 Identities = 97/230 (43%), Positives = 158/230 (69%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEAVIARIDPSIVVQ--WRYREGDRMTADSTVCELDGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ +  Q   ++++GDR+T++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+A+ T  YV+ + + R K++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALNAGVP-VQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE  240
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A G + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  AVRVAAGKAVLEVSGGVYFDTVRTFAETGVDRISIGALTKDVRATDYSMR  290
            A+ + AG++ +E SG +   T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

546) nadC in NC_019670


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  144 bits (528),  Expect = 8e-36, Method: Compositional matrix adjust.
 Identities = 118/279 (43%), Positives = 200/279 (72%), Gaps = 7/279 (2%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LATATIITRDAAVISGTAWVDNVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  A  ++++++A+V++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERVTPNQVLFHLEGPARSLLTGERSALNFLQLLSGVATR-AQY  121
             +D+ V+ +   Q  DG+R+T+ ++++++ G+ RSLLT ER ALNFLQ LSG+A+  A Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  LADFVAETQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaasggia  181
            +   +++ ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ 
Sbjct  126  VEA-LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  qaiaaahkiap-gKPVEIEVESLDELKEALAAGADIIMLDELSLDDMREAVRLNAGKAKL  240
            +AIA A+  AP  K VE+EVESL    EA AAG DIIMLD++SL+++ +A+ L AG++++
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  241  EASGGINESTLLPIARTGVDYISIGAMTKDVKAVDLSMR  279
            E SG I+ +T+  +   ++DY+S G++T   K++D+SM+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

547) Cphamn1_2190 in NC_010831


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (526),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 102/241 (43%), Positives = 168/241 (70%), Gaps = 8/241 (3%)

Query  49   AKTDGVVAGIAVVDQVFRAIDRDIVVNPA--VCDGAQVSEGDIVLEGEGKIASLLVAERT  106
            AK  GV+AG++V ++VF  +D ++  + +    DG +++ GD+VLE  G + SLL  ER 
Sbjct  48   AKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERV  107

Query  107  ALNFMQRMSGIATRTRSFVERVSHTGAKILDTRKTAPGLRYFDKEAVKIGGGKNHRYGLF  166
            ALNF+Q++SGIA+ T ++VE +++   K++DTRKT+P LR F+K AV++GGG NHR+ L 
Sbjct  108  ALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLS  167

Query  167  DLVLIKDNHIDASGGVVPAVGRARKYLAEKGMAMKIEVEVRSFEELQQAIGAGPDIILLD  226
            D +++KDNHI A G+V  A+++AR Y         +EVEV S+   ++A +AG DII+LD
Sbjct  168  DAIMLKDNHIAAVGSVQKAIAQARAY---APFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  227  NFSVDELaaavafarqhaQEILLEASGNVGLHTVAEIAGTGVDYISVGELTHSVSALDLS  286
            N S++++  A+++   +++   +E SGN+++ T++ + G ++DY+S G LTHS  +LD+S
Sbjct  225  NMSLEQIEQAITLIAGRSR---IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

Query  287  M  287
            M
Sbjct  282  M  282

548) Deba_0027 in NC_014365


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (525),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 111/262 (43%), Positives = 181/262 (70%), Gaps = 2/262 (0%)

Query  14   LAEDLGRGDITSTAVVAEDSWATGRFVCKDQGVLAGLPAARMVFALLDGAVEF--TPLLA  71
            L ED+   D ++ A+  +++ A   +  K+ GVLAGL   + VF+L+D+ V F     + 
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  72   EGAPLRPGQALATVRGPARAILAGERLALNLLQRasgvaslaaqavaavqgHKAKILDTR  131
            +G  L +G+ +  + G+ R++L+ ER+ALN+LQ+ SG+AS++A  V A+ +++ K++DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  132  KTTPGLRWLEKYAARVGGAVNHRFGLDDAVLIKDNHlalaggvgpalaraKAAVGPMVVI  191
            KTTP LR +EKYA RVGG+ NHRF L DA+++KDNH+A  G+V  A+A+A+A    + ++
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  192  EVEVESleqlaqaleagagVIMLDNMPAALMAQAVKLCAGRAVLEASGGLDLARLAEVAA  251
            EVEVESL    +A  AG ++IMLDNM+   + QA+ L AGR+ +E SG +D++ ++   +
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  252  TGVDYISMGWLTSGAKPLDIGL  273
             ++DY+S G LT +AK+LD+++
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSM  282

549) Dhaf_0158 in NC_011830


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (525),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 117/277 (43%), Positives = 187/277 (68%), Gaps = 9/277 (3%)

Query  3    APFQYQELIERALQEDLGTGDLSS-AIFPKTAKTHAKIYAKQKGIACGLEITKQVFKTVD  61
            +PFQ ++ +  AL+ED+ + D S+ AIF   +++   ++AK+ G+  GL + ++VF   D
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  62   PELEVSISKA--DGELVERGTVVMEITGAICSILSAERTALNFLQHLSGVA--TATF-EA  116
            +E+    +    DG+ +  G +V+EI G++ S+L+ ER ALNFLQHLSG+A  TA++ EA
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  117  VTECYGLPTRITDTRKTIPGLRMLQKYAVAMGGGQNHRFGLYDAVMLKDNHiaaaggirp  176
            + +      ++ DTRKT P LR+++KYAV +GGG NHRF L DA+MLKDNHIAA G+++ 
Sbjct  129  LGDD---RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  177  avaaarSRIGHMVKIEVECENLeqvqeavaagaevIMLDNMNLETMGKAVEIVQGRAVVE  236
            A+A AR+    +  +EVE E+L   +EA AAG ++IMLDNM+LE + +A+ ++ GR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  237  ASGGIRKGDLRAVAETGVDVISMGAITHSVQAMDFSL  273
             SG I    +      ++D +S G++THS +++DFS+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

550) nadC in NC_007907


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (526),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 117/277 (43%), Positives = 187/277 (68%), Gaps = 9/277 (3%)

Query  4    APFQYQELIERALQEDLGTGDLSS-AIFPKTAKTHAKIYAKQKGIACGLEITKQVFKTVD  62
            +PFQ ++ +  AL+ED+ + D S+ AIF   +++   ++AK+ G+  GL + ++VF   D
Sbjct  9    TPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFD  68

Query  63   PELEVSISKA--DGELVERGTVVMEITGAICSILSAERTALNFLQHLSGVA--TATF-EA  117
            +E+    +    DG+ +  G +V+EI G++ S+L+ ER ALNFLQHLSG+A  TA++ EA
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  118  VTECYGLPTRITDTRKTIPGLRMLQKYAVAMGGGQNHRFGLYDAVMLKDNHiaaaggirp  177
            + +      ++ DTRKT P LR+++KYAV +GGG NHRF L DA+MLKDNHIAA G+++ 
Sbjct  129  LGDD---RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  178  avaaarSRIGHMVKIEVECENLeqvqeavaagaevIMLDNMNLETMGKAVEIVQGRAVVE  237
            A+A AR+    +  +EVE E+L   +EA AAG ++IMLDNM+LE + +A+ ++ GR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  238  ASGGIRKGDLRAVAETGVDVISMGAITHSVQAMDFSL  274
             SG I    +      ++D +S G++THS +++DFS+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

551) nadC in NC_021362


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (525),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 113/270 (42%), Positives = 178/270 (66%), Gaps = 4/270 (1%)

Query  8    NMLKEFFKEDIGWGDFTSEAVFDDNLQCEAVITAKDDGLFAGELVIFE-GFRLLDETIAV  66
            + LK  ++ED+   D++++A+FD++ Q    + AK+ G++AG L +F+  F L+D  ++ 
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAG-LTVFQRVFTLFDAEVTF  73

Query  67   QLLK--TDGEAVHKGETIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSVIRLDDPD  124
            Q      DG+ +  G+ +  + G   SL+T ERV LN++Q++SGIA++T   V  L+D  
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  125  IAICDTRKTTPGLRILEKYAIKTGGGCNHRFGLDGGIMIKDNHIAACGSILKAVEKARAA  184
            I + DTRKTTP LR++EKYA++ GGG NHRF L ++IM+KDNHIAA GS+ KA+ +ARA 
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  185  CGHMvkieveiesekeLHEAIAAEADIIMFDNCPPDKVKAFAEMTPAGIMTEASGGISFE  244
               +  +EVE+ES    +EA AA  DIIM+DN + +++     + ++    E SG I   
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  245  NLPAYRGTGVHCISLGYLTHSAKSLDISMN  274
             ++ +RG +++ +S G LTHSAKSLD+SM+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

552) nadC in NC_017532


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (525),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 191/278 (69%), Gaps = 5/278 (1%)

Query  7    ADLSA-EIDANARRALAEDVGSGDITAQLIPAER-LAHASVITREAAVISGTAWVDAVFR  64
            +DL++ +ID   + AL EDV S D +++ I  ++  A  S++++EA+V++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QVDSRVAVH--WQVADGDRVEADKVLFHLEGPARALLTGERSALNFLQMLSGVATRCRHY  122
              D+ V+ +   Q  DGDR+ ++ +++++ G+ R+LLT ER ALNFLQ LSG+A+    Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADMVEGTGVRLLDTRKTIPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaacggiae  182
             + + +  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaahriaP-GKPVEIEVESLDELEQALGAGADIVMLDELTLDDMRTAVAITAGRAKLE  241
            A+A A+  AP  K VE+EVESL   E+A +AG DI+MLD+++L+++  A+++ AGR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGISDDTLRSVAQTGVDYISIGALTKHVQAVDLSMR  279
             SG I   T+      ++DY+S G+LT   +++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

553) nadC in NC_013790


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (525),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 99/244 (41%), Positives = 159/244 (66%), Gaps = 11/244 (4%)

Query  34   LISKDEGILAGIEIIKEIFLEYGIDILSSK----NDGDEIKKGDILLEIEGNARKILLLE  89
            L++K+ G+LAG+ +++ +F  ++ ++   +    +DGD +  GD++LEI G+ R +L  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  90   RTALNLLMRMSGVATKTHRVVSSVKEVNDKVRVAGTRKTAPALQKYDKIAISIGGGDPHR  149
            R ALN+L ++SG+A+ T   V ++ +  D+++V +TRKT+P L+ ++K A+ +GGG  HR
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGD--DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  150  YGLDDMVLIKDNHIAVVGSVKDALRLAKENVSFSKKIEIEVESADDAVIAAENGADIIMF  209
            + L D +++KDNHIA VGSV+ A+  A+   +F K +E+EVES   A  AA  G DIIM+
Sbjct  164  FNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIML  223

Query  210  DNMSPKEAQDSLDALIDNDLRNGVLIEISGGITEDNILDYAPLDVDIISLGSLTHQASSL  269
            DNMS  + ++++ +LI    R    IE SG I    I  +  L +D +S GSLTH A SL
Sbjct  224  DNMSLEQIEQAI-TLIAGRSR----IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  270  NFSL  273
            +FS+
Sbjct  279  DFSM  282

554) Sulba_0257 in NC_018002


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (525),  Expect = 1e-35, Method: Compositional matrix adjust.
 Identities = 107/262 (41%), Positives = 155/262 (60%), Gaps = 10/262 (3%)

Query  12   EDIGRGDLFNLVGKNSFASANIICKDVGIFAGKPYVKALCKMNKLDITFY----FKDGDT  67
            ED +   +F+  G+   A  +++ K+ G++AG    + +  +   ++TF     FKDGD 
Sbjct  28   EDYSTNAIFDHHGQ---AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDR  84

Query  68   LQKGDLVARIEGKSKTILRCERTILNLMQHASGIASNVAQYKKVLQGYSLKLLDTRKTRP  127
            L  GDLV  I G  +++L CER  LN++QH SGIAS  A Y   L +  +K++DTRKT P
Sbjct  85   LTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTP  144

Query  128  HLRIFEKYAIRCGGGNNHRMGLDDCLMLKDTHLQTINDLKSFIQEAREKIPFTCKIEIEC  187
            +LR+FEKYA+R GGG NHR  L D +MLKD H+ ++  ++  I +AR   PF   +E+E 
Sbjct  145  NLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEV  204

Query  188  EDVDFAKFAMQCGADIVMCDNMSHEAIAAVVAYKNSDFPHVLLEASGNITKDNIIQYAQT  247
            E +  A  A   G DI+M DNMS E I   ++   +   +  +E SGNI    I ++   
Sbjct  205  ESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG---RSRIECSGNIDMTTISRFRGL  261

Query  248  GVDAISSGSLIHHATWLDFSMK  269
            ++D +SSGSL H A  LDFSMK
Sbjct  262  AIDYVSSGSLTHSAKSLDFSMK  283

555) nadC in NC_002977


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (527),  Expect = 9e-36, Method: Compositional matrix adjust.
 Identities = 107/261 (41%), Positives = 175/261 (68%), Gaps = 4/261 (1%)

Query  19   EDLGSGDLTADVV-PASVSARAEVVTRESMVLCGQAWFEAVFRRLDPAVRVIWLAE--EG  75
            ED+ S D +++ +      A+  + ++E+ VL G + F+ VF  +D+ V      +  +G
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  76   AEVSAADRVCEVEGNARALLSGERTALNLLQTLSGTATIARRYAQAVAGTGVKVLDTRKT  135
              ++++D V E+ G+ R+LL+ ER ALN+LQ LSG A+++  Y +A+++  +KV+DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  136  LPGLRLAQKYAVRCGGCHNHRAGLYDAVLIKENHIAAAGSIGEAVATARRLHPGV-LVEV  194
             P LRL +KYAVR GG  NHR  L DA+++K+NHIAA GS+  A+A AR   P V +VEV
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  195  EVENFPELEQALAAGADRIMLDDFERDALSKAVAVAAGRAELEVSGSIDLDSIRAVAETG  254
            EVE+++  E+A AAG D IMLD+   + + +A+++ AGR+ +E SG+ID+ +I      +
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA  262

Query  255  VDFISVGGLTKHLRAIDLSMR  275
            +D++S G+LT   +++D+SM+
Sbjct  263  IDYVSSGSLTHSAKSLDFSMK  283

556) nadC in NC_012660


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  143 bits (527),  Expect = 9e-36, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 197/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LATATIITRDAAVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  A  ++++++A+V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERVSPNQALFHLEGPARSLLSGERCALNFLQLLSGVATRAQFL  122
             +D+ V+ +   Q  DG+R+++ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADFVASTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIAQ  182
             + ++  ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  AITAAHKIAP-GKPVeievesleelrealaagaDIIMLDELSLDDMREAVRLNGGKAKLE  241
            AI+ A+  AP  K VE+EVESL    EA AAG DIIMLD++SL+++ +A+ L +G++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGINESTLLPIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG I+ +T+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

557) nadC in NC_014974


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (522),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 124/269 (47%), Positives = 185/269 (69%), Gaps = 4/269 (1%)

Query  16   ETLKAWLLEDLGHGDLTTALTVPEDLMGEAVILAKEEGVLAGLPVAREVFTLVDHRIAF-  74
            +TLKA L ED+   D +T     ++  +   ++AKE GVLAGL V + VFTL D  ++F 
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  75   -TPLVEEGTKVDPGHEVARLEGPLRGILAGERLALNLLQRLSGIATLTRAYVEALKGTKA  133
                  +G ++ +G+ V  + G++R++L+ ER+ALN+LQ+LSGIA++T AYVEAL + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  134  QVLDTRKTTPGLRALEKYAVRVGEGKNHRFGLFDGILIKENHIraaggvaqavrkakaka  193
            +V+DTRKTTP LR +EKYAVRVG G NHRF L D+I++K+NHI A G+V +A+ +A+A A
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  194  PHYLKvevevtrl-aeleealeagadlillDNFSLEEMREAVRRVGGRVPLEASGNMTLE  252
            P ++K+        A  EEA  AG D+I+LDN SLE++ +A+  ++GR  +E SGN+ + 
Sbjct  195  P-FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  253  RARAAAEAGVDYVSVGALTHSAKALDLSL  281
                    ++DYVS G+LTHSAK+LD+S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

558) ST1198 in NC_003106


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (524),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 104/243 (43%), Positives = 159/243 (66%), Gaps = 8/243 (3%)

Query  34   KAIIISKDEGILAG----QKFIIPFLEYLGIKIENYMKDGTQIKKKDIVLEIEGDAETIL  89
            K  +++K+ G+LAG    Q+ +  F   + ++  +  KDG ++   D+VLEI G   ++L
Sbjct  43   KVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL  102

Query  90   GVERLVLNLLGKLSGISTVTH-LMTRLAKSVNPYVRIAGTRKTTPGLRVFEKYAIEVGGG  148
              ER+ LN+L  LSGI+++T   +  L+      +++ +TRKTTP LR+FEKYA+ VGGG
Sbjct  103  TCERVALNFLQHLSGIASMTAAYVEALGDDR---IKVFDTRKTTPNLRLFEKYAVRVGGG  159

Query  149  DPHRFNLSDAVLIKDNHIALIGSVKEAIRRAKEITSFTKKIEVEVSSLKDALEAYQAGAD  208
              HRFNLSDA+++KDNHIA +GSV+ AI +A+  ++F K +EVEV SL  A EA  AG D
Sbjct  160  YNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVD  219

Query  209  AILLDNMKPEEIIPVVNELKGKVIVEASGGINPDNVIEYAKTGVDIISSGYITHSSRSLD  268
             I+LDNM  E+I   +  + G+  +E SG I+   +  +   ++D +SSG +THS++SLD
Sbjct  220  IIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD  279

Query  269  FSL  271
            FS+
Sbjct  280  FSM  282

559) Acife_1212 in NC_015942


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (523),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 114/276 (42%), Positives = 192/276 (70%), Gaps = 3/276 (1%)

Query  1    MIPADLSLSVQQALAEDIGSGDL-TAALIPAATQLRAQILSREAGILCGQAYAEATFAAL  59
            + P ++  +++ AL ED+ S D  T A++    Q +  ++++EAG+L G +  +  F+ +
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   SS--TIQMHWHSAEGASVAPDQVLCILEGPARALLTGERTALNFLQTLSGTATQVRAYVD  117
             +  T+Q   +  +G  +++++++  + G+ R+LLT ER ALNFLQ LSG A+   AYV+
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  118  ALSGHKTRLLDTRKTIPGLRQAQKYAVRIGGGHNHRLGLYDGILIKENHIAACGSITaal  177
            AL++++ +++DTRKT P LR  +KYAVR+GGG NHR+ L D+I++K+NHIAA GS+  A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  178  qaarqiapalTRIevevenllqleealTAGTDMVLLDNFSLEDLRHAVQRVAGRLPLEAS  237
              AR  AP +  +EVEVE+L   EEA +AG D+++LDN SLE++ +A+  +AGR  +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  238  GNIGVHNIAAVAATGVDFISVGSLTRNLRSLDLSLR  273
            GNI++  I+   + ++D++S GSLT++ +SLD+S++
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

560) nadC in NC_009434


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (522),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 114/278 (42%), Positives = 191/278 (69%), Gaps = 5/278 (1%)

Query  7    ADLSA-EIDANARRALAEDVGSGDITAQLIPTER-LAHASVITREAAVISGTAWVDAVFR  64
            +DL++ +ID   + AL EDV S D +++ I  ++  A  S++++EA+V++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QVDSRVAVH--WQVADGDRVEADRVLFHLEGPARALLTGERSALNFLQMLSGVATRCRHY  122
              D+ V+ +   Q  DGDR+ ++ +++++ G+ R+LLT ER ALNFLQ LSG+A+    Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADMVEGTGVRLLDTRKTIPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaacggiae  182
             + + +  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaahriaP-GKPVEIEVESLDELEQALGAGADIVMLDELTLDDMRTAVAITAGRAKLE  241
            A+A A+  AP  K VE+EVESL   E+A +AG DI+MLD+++L+++  A+++ AGR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGISDDTLRSVAQTGVDYISIGALTKHVQAVDLSMR  279
             SG I   T+      ++DY+S G+LT   +++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

561) nadC in NC_002932


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (523),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 113/276 (41%), Positives = 175/276 (64%), Gaps = 11/276 (3%)

Query  24   AMQLALEEDRFQGDITTEATVDQNQLGLGYIEVKSEGIIAGVEVARQVFQSLDAALEFTA  83
            +++ AL ED    D +T+A  D++  +   +  K  G++AG+ V ++VF  +DA + F  
Sbjct  16   TLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  84   ---YVKDGKRVYPGERVLEVKGRIASILIGERTALNFMQRMSGIATRTNMYVERVSHTNA  140
               + KDG R+ +G+ VLE+ G + S+L  ER ALNF+Q++SGIA+ T  YVE +++   
Sbjct  76   PHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  141  SILDTRKTAPALRYYDKEAVRIGGGTNHRFGLFDMILIKDNHIDAAGSVEEAIRRAKAYC  200
             ++DTRKT+P LR ++K AVR+GGG NHRF L D I++KDNHI A GSV+ AI +A+AY 
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY-  193

Query  201  QEQGVSAKIETEVRSISELVRACASRPDMILLDNFMVDDLAEAVRWIKANGFGNILLEAS  260
                    +E EV S++    A A+  D+I+LDN  ++++ +A+  I     G   +E S
Sbjct  194  --APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA----GRSRIECS  247

Query  261  GNIGLHNVSEVAMTGVDFISIGELTHSVKALDMSMK  296
            GNI++  +S     ++D++S G LTHS K+LD SMK
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

562) amb3885 in NC_007626


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (522),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 95/237 (41%), Positives = 157/237 (67%), Gaps = 4/237 (1%)

Query  51   MAARHTMVVAGMPVAQEVFRLVVPEARFTA--RVADGDTVEAGTVLAEMEGPARGLLTAE  108
            + A+++ V+AG+ V Q VF L  +E  F    +  DGD + +G ++ E+ G+ R+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  109  RTALNLLQLLSGIATLTSQYAKRIQGTGCTLLDTRKTIPGLRRLSKYATRCGGAKNHRMG  168
            R ALN+LQ LSGIA++T+ Y   + +    ++DTRKT P LR + KYA R GG+ NHR  
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  169  LYDGVLIKDNHIAVCGGVGEAVRRAKAEGR--PNIEAECDTLEQVAEAVEAGADIVLLDN  226
            L D++++KDNHIA  G+V  A+ +A+A +     +E E ++L    EA  AG DI++LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  227  MGPDVLRRAVAIVAGRAKTEASGGVTLDTIRAIAETGVDFVSVGRITQSAPAVDIGL  283
            M+ + + +A++++AGR++ E SG + + TI  +   ++D+VS G +T+SA ++D+++
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

563) nadC in NC_020133


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (522),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 110/272 (41%), Positives = 177/272 (66%), Gaps = 5/272 (1%)

Query  13   ETIRRGLDEDLRYGPDVTTIATVPADATATASMVPREAGVIAGVDVALMVLDEVIGKDGY  72
            +T++ +L ED++ + D +T A    ++ A  S+ ++EAGV+AG+ V   V+    +   +
Sbjct  15   DTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  73   QVLGRVDDGARLQTGEPVLTIRAQTRGLLTAERTMLNLVCHLSGIATATAAWVEAVDGTK  132
            Q   +  DG RL +G+ VL I +  R+LLT ER  LN++ HLSGIA+ TAA VEA+++ +
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  133  AKIRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDVALIKDNHVAAAGSvlealravraa  192
             K+ DTRKT P LR ++KYAVRVGGG NHR+ L+D  ++KDNH+AA GSV  A+   RA 
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  193  aPDLP-CEVEVDSLEQLDEVLPEKPELILLDNFPVWQTQTAVQRRDSRAPTVLLESSGGL  251
            AP +   EVEV+SL   +E  +   ++I+LDN ++ Q + A+    +R+    +E SG +
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNI  250

Query  252  SLDTAATYAATGVDYLAVGALTHSVRVLDIGL  283
             + T + + + ++DY++ G+LTHS + LD+++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

564) nadC in NC_018220


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (522),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 195/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRENCVVAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGEQATANQPLFHLEGPARSLLSGERSALNFLQLLSGVATRARFL  122
             +D+ V+ +   Q  DG++ T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVAGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvae  182
             + +++ +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIIMLDELSLDEMREAVRITAGKAKLE  241
            A+A A+  AP  K VE+EVESL    +A AAG DIIMLD++SL+++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

565) nadC in NC_015740


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (524),  Expect = 2e-35, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 191/278 (69%), Gaps = 5/278 (1%)

Query  7    ADLSA-EIDANARRALAEDVGSGDITAQLIPAER-LAHATVITREAAVISGTAWVDAVFR  64
            +DL++ +ID   + AL EDV S D +++ I  ++  A  +++++EA+V++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QVDSRVAVH--WQVADGDRVEADKVLFHLEGPARALLTGERSALNFLQMLSGVATRCRHY  122
              D+ V+ +   Q  DGDR+ ++ +++++ G+ R+LLT ER ALNFLQ LSG+A+    Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADMVEGTGVRLLDTRKTIPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaacggiae  182
             + + +  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaahriaP-GKPVEIEVESLDELEQALGAGADIVMLDELTLDDMRTAVAITAGRAKLE  241
            A+A A+  AP  K VE+EVESL   E+A +AG DI+MLD+++L+++  A+++ AGR+++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGISDDTLRSVAQTGVDYISIGALTKHVQAVDLSMR  279
             SG I   T+      ++DY+S G+LT   +++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

566) nadC in NC_013791


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (522),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 107/263 (41%), Positives = 171/263 (66%), Gaps = 8/263 (3%)

Query  29   EDIGHGDLTSEAIFDNE-KGKAYFLAKDEGIFCGEEVIFSAYQLFDPAIEVIMHK----K  83
            ED+   D +++AIFD++ ++K  ++AK+ G++ G  V+   + LFD+  EV  ++    K
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA--EVTFQNPHQFK  80

Query  84   DGDAVRGGEIICEVYGKARDLLTSERVILNIIQRLSGIATETNKAVKKMEGTSIRICDTR  143
            DGD + +G+++ E+ G  R LLT ERV LN++Q+LSGIA+ T   V  + +  I++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  144  KTTPGLRMLEKHAVTCGGGFNHRFGLHDAVLIKDNHIAQCGGDLDTAVKRVKEKLGHMVK  203
            KTTP LR++EK AV  GGG+NHRF L DA+++KDNHIA  G+ ++ A+ + +     +  
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS-VQKAIAQARAYAPFVKM  199

Query  204  VEVEVESREQVKRAVASNVDVIMFDNCSPTEAKEWRKLVPDTIVVELSGGITLHQLEEYV  263
            VEVEVES      A A+ VD+IM+DN S  +  +   L+++   +E SG I +  +  + 
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  264  HTGVDYISMGALTHSVKALDISL  286
              ++DY+S G+LTHS K+LD+S+
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSM  282

567) N175_12765 in NC_022223


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (521),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 186/278 (67%), Gaps = 7/278 (2%)

Query  19   PLEITRAVSDALREDLGGSLDATADITANLIPADARNTATLITREHGVFCGQAWAEEVFK  78
            P++I  ++  ALRED+    ++    T  ++  +++   +L+++E GV+ G +  + VF 
Sbjct  10   PFQIDDTLKAALREDV----HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  79   QLGGEVKID--WHVQDGDQVKPNQVLCTLEGPARALLTGERNAMNFIQTLSGCASITAQY  136
             +++EV ++   + +DGD++ + +++  + G+ R+LLT ER A+NF+Q LSG AS+TA Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  137  AKQLEGTECRLLDTRKTIPGLRSALKYAVACGGGFNHRISVFDAYLIKENHIIACGGITQ  196
               L +   +++DTRKT P LR   KYAV  GGG+NHR+++ DA ++K+NHI A G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  197  AIGTAKQLNP-GKPveveteslqeleeAIQAGADIIMLDNFSIEMMREAVAINAGRAALE  255
            AI+ A+   P  K VEVE ESL   EEA  AG DIIMLDN S+E + +A+++ AGR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  256  NSGNVTLETIGDYARTGVDYISVGALTKHIKALDLSMR  293
             SGN+ + TI+ +   ++DY+S G+LT   K+LD+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

568) nadC in NC_010612


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (521),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 177/272 (66%), Gaps = 5/272 (1%)

Query  13   ETIRRGLDEDLRYGPDVTTIATVPADATATASMVPREAGVIAGVDVALMVLDEVIGKDGY  72
            +T++ +L ED++ + D +T A    ++ A  S+ ++EAGV+AG+ V   V+    +   +
Sbjct  15   DTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  73   QVLGRVDDGARLQTGEPVLTIRAQTRGLLTAERTMLNLVCHLSGIATATAAWVEAVHGTK  132
            Q   +  DG RL +G+ VL I +  R+LLT ER  LN++ HLSGIA+ TAA VEA+ + +
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  133  AKIRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVAAAGSvlealravraa  192
             K+ DTRKT P LR ++KYAVRVGGG NHR+ L+DA ++KDNH+AA GSV  A+   RA 
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  193  aPDLP-CEVEVDSLEQLDEVLPEKPELILLDNFPVWQTQTAVQRRDSRAPTVLLESSGGL  251
            AP +   EVEV+SL   +E  +   ++I+LDN ++ Q + A+    +R+    +E SG +
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNI  250

Query  252  SLDTAATYAATGVDYLAVGALTHSVRVLDIGL  283
             + T + + + ++DY++ G+LTHS + LD+++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

569) YSA_06639 in NC_017986


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (521),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 195/278 (71%), Gaps = 5/278 (1%)

Query  11   ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRENCVVAGTAWVDAVFR  68
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  69   QLDPRVAVH--WQVADGEQATANQPLFHLEGPARSLLSGERSALNFLQLLSGVATRARFL  126
             +D+ V+ +   Q  DG++ T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  127  ADLVAGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvae  186
             + +++ +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  187  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIIMLDELNLEEMREAVRITAGKAKLE  245
            A+A A+  AP  K VE+EVESL    +A AAG DIIMLD+++LE++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  246  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  283
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

570) Spea_0415 in NC_009901


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (521),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 101/248 (41%), Positives = 168/248 (68%), Gaps = 9/248 (3%)

Query  48   AQASLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLVLPNQLLCELEGPARAI  105
            A+ SL+++E GV+ G +  ++VF  +++EV+++   +  DGD + + +L+ E+ G+ R++
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  106  LTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGQN  165
            LT ER A+NF+Q LSG+A++T  YV+ L++ + +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  166  HRIGLFDAFLIKENHIMACGSIAKAIQAARELNA-DKPVEVEVESIDELKQALDAQSDIV  224
            HR+ L DA+++K+NHI A GS+ KAI  AR   +  K VEVEVES+    +A  A  DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  225  MLDNFDVTMMIEAVELNNSYKARGQGVKLEVSGDVTLDTIANFAKTGVDYISVGALTKHV  284
            MLDN  +  + +A+ L  + ++R     +E SG++ + TI+ F   ++DY+S G+LT   
Sbjct  222  MLDNMSLEQIEQAITLIAG-RSR-----IECSGNIDMTTISRFRGLAIDYVSSGSLTHSA  275

Query  285  RALDLSLR  292
            ++LD+S++
Sbjct  276  KSLDFSMK  283

571) VAA_00733 in NC_015633


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  142 bits (521),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 185/278 (67%), Gaps = 7/278 (2%)

Query  19   PLEITRAVSDALREDLGGSLDATADITANLIPADARNTATLITREHGVFCGQAWAEEVFK  78
            P++I  ++  ALRED+    ++    T  ++  +++   +L+++E GV+ G +  + VF 
Sbjct  10   PFQIDDTLKAALREDV----HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  79   QLGGEVKID--WHVQDGDQVKPNQVLCTLEGPARALLTGERNAMNFIQTLSGCASITAQY  136
             +++EV ++   + +DGD++ + +++  + G+ R+LLT ER A+NF+Q LSG AS+TA Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  137  AKQLEGTECRLLDTRKTIPGLRSALKYAVACGGGFNHRIGVFDAYLIKENHIIACGGITQ  196
               L +   +++DTRKT P LR   KYAV  GGG+NHR+ + DA ++K+NHI A G++ +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  197  AIGTAKQLNP-GKPveveteslqeleeAIQAGADIIMLDNFSIEMMREAVAINAGRAALE  255
            AI+ A+   P  K VEVE ESL   EEA  AG DIIMLDN S+E + +A+++ AGR+ +E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  256  NSGNVTLETIGDYARTGVDYISVGALTKHIKALDLSMR  293
             SGN+ + TI+ +   ++DY+S G+LT   K+LD+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

572) nadC in NC_009485


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (520),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 120/267 (45%), Positives = 187/267 (71%), Gaps = 3/267 (1%)

Query  15   VRMALAEDLGRAGDITTDAIVPAERRASLQLRARQPGVIAGLDVARCAFQTLSPEVRMEI  74
            ++ AL ED+ ++ D +T+AI   + +A + L A+++GV+AGL V +  F  + +EV  + 
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  75   IRG--DGGAVEPGDVIATISGPARALLTGERVALNFLCHLsgvasataslvaavKGTRAQ  132
             +   DG+ + +GD++  I G+ R+LLT ERVALNFL HLSG+AS TA+ V A+ + R +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  133  IVCTRKTTPGLRALEKYAVRAGGGGNHRFGLDDAVLIKDNHIAIAGGIKPAITSARAHAG  192
            +  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHIA  G+++ AI+ ARA A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  193  HLVKIEVEVDTLAQleealalgvdavlldNMTSPELARAVAMTGGRAITEASGRITVETa  252
             +  +EVEV++LA  EEA A GVD ++LDNM+  ++ +A+++ +GR+  E SG I + T 
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  253  aaiaaaGVDLISVGWITHSAAALDIGL  279
            + + + ++D +S G +THSA +LD+++
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

573) Pput_0810 in NC_009512


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (520),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 113/278 (41%), Positives = 195/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRENCVVAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGEQATANQPLFHLEGPARSLLSGERSALNFLQLLSGVATRARFL  122
             +D+ V+ +   Q  DG++ T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVAGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvae  182
             + +++ +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIIMLDELNLEEMREAVRITAGKAKLE  241
            A+A A+  AP  K VE+EVESL    +A AAG DIIMLD+++LE++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

574) nadC in NC_002947


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (520),  Expect = 3e-35, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 195/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRENCVVAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGEQASANQPLFHLEGPARSLLSGERSALNFLQLLSGVATRARFL  122
             +D+ V+ +   Q  DG++ ++ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVAGTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvae  182
             + +++ +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVEIEVESLDELRQALAAGADIIMLDELSLDEMREAVRITAGKAKLE  241
            A+A A+  AP  K VE+EVESL    +A AAG DIIMLD++SL+++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

575) Desac_2157 in NC_015388


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (520),  Expect = 4e-35, Method: Compositional matrix adjust.
 Identities = 113/264 (43%), Positives = 176/264 (67%), Gaps = 2/264 (0%)

Query  15   ALEEDLGPGDITTEAVISPEIMAEAHIRAKERLVVAGLPVAEAVFAHLGSEIIFN--PRV  72
            AL ED+ + D +T+A++  +  A   + AKE  V+AGL V + VF+ +++E+ F+   + 
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  73   AEGEVVRPKTVLASVVGPAVLLLMGERVALNFLMRLSGIATWTRQFVEAVQLSAAQIVDT  132
             +G+ + +  ++  ++G+   LL  ERVALNFL +LSGIA+ T  +VEA+     ++ DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  133  RKTTPGWRVLEKYAVRVGGGANHRFGLFDGVLIKDNHiraaggvataiaaarqavPHTLR  192
            RKTTP  R++EKYAVRVGGG NHRF L D++++KDNHI A G+V  AIA AR   P    
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  193  IEVEVSDLPgleealaagaDVILLDNMENDSLAEAVRVAGGQVILEASGGMTLERVSEVA  252
            +EVEV  L++ EEA AAG D+I+LDNM  + + +A+ + +G+  +E SG + +  +S   
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  253  AAGVDFISVGALTHSAPAVDMHMK  276
            + ++D++S G+LTHSA ++D  MK
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

576) Nos7107_2235 in NC_019676


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (519),  Expect = 4e-35, Method: Compositional matrix adjust.
 Identities = 116/270 (43%), Positives = 179/270 (67%), Gaps = 6/270 (2%)

Query  18   RGWLLEDIGRGDRTTNPLFTSNLTLGTAKLFAKATGIIAGLSVAARVFQLLNEKTSF--T  75
            ++ L ED+   D +TN++F  +   +   LFAK +G++AGL+V  RVF L++   +F   
Sbjct  18   KAALREDVHSEDYSTNAIFDHH-GQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  76   MIVNDGEFCQPGQVIAEIHGSLDTLLMGERVALNLAMRLSGIATLTHKYVEKIADFPVQF  135
               +DG+   +G+++ EI GS+ +LL  ERVALN+  +LSGIA++T  YVE ++D  ++ 
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  136  VDTRKTTPGLRILEKYATAVGGAINHRMGLDDAVMIKDNHiaaaggigeaiTQIRSQIPY  195
             DTRKTTP LR++EKYA  VGG+ NHR  L DA+M+KDNHIAA G++  AI+Q R+  P+
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  196  PStievetetieqvkeALEYKADIIMLDNMRLDVVLEAVSLIRQQNTLVKIEASGNVTLD  255
               +EVE E++    EA     DIIMLDNM L+ + +A++LI  ++   +IE SGN+ + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGNIDMT  253

Query  256  NIRDLAATGVDYISSSAPITQSKWLDLSMK  285
             I  + + ++DY+SS++    +K LD+SMK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

577) all2091 in NC_003272


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (517),  Expect = 5e-35, Method: Compositional matrix adjust.
 Identities = 115/270 (43%), Positives = 173/270 (65%), Gaps = 6/270 (2%)

Query  18   RGWLLEDIGRGDRTTNGLLAADVTLGSAKWIAKTPGVIAGLPVAARVFQLLNEKVSFVTT  77
            ++ L ED+   D +TN+++  +   +    +AK +GV+AGL V  RVF L++  V+F   
Sbjct  18   KAALREDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  78   --VDEGAFCEPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATLTKIYVEKIADLPACL  135
                +G    +G++V EI GS+ +LL  ERVALN+   LSGIA++T  YVE ++D    +
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  136  VDTRKTTPGLRLLEKYATAMGGAINHRMGLDDAVMIKDNHiaaaggigkaiTRIRSQIPY  195
             DTRKTTP LRL+EKYA  +GG+ NHR  L DA+M+KDNHIAA G++ KAI++ R+  P+
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  196  TLTIEVEAETIEQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQDNGVKIEASGNVTLE  255
               +EVE E++    EA     DIIMLDNM+++ + QA+ LI  +    +IE SGN+ + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGNIDMT  253

Query  256  TIRAVAETGVDYISSSAPITQSKWLDLSMR  285
            TI      ++DY+SS++    +K LD+SM+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

578) Theco_3679 in NC_019897


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (518),  Expect = 5e-35, Method: Compositional matrix adjust.
 Identities = 119/281 (43%), Positives = 187/281 (67%), Gaps = 7/281 (2%)

Query  3    ELDRYNEAIRSMIRGWLDEDIGYGDITTESTIPAGSRHKAVIHVKEDGVLAGLPVARLVF  62
            +L  ++  I   +++ L ED+   D +T++ +   ++ K  +  KE GVLAGL V + VF
Sbjct  7    DLTPFQ--IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  63   HVVDPTLEFRALAE--DGQKVAKGTVIAEVEGSTHSILTGERLALNLLQRMSGIATKTRR  120
             + D+ + F+   +  DG++++ G ++ E+ GS +S+LT ER+ALN+LQ++SGIA+ T  
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  121  FVDALEGLPVRLVDTRKTTPGHRLLEKYAVRMGGGANHRFGLYDAVMIKDNHikgaggir  180
            +V+AL +  +++ DTRKTTP  RL+EKYAVR+GGG NHRF L DA+M+KDNHI + G+++
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  181  aavaaarariPHtmtievetetieQVREALEAGADIIMLDNMPPAGMAEAVKLIRERAPH  240
             A+A ARA  P    +EVE E++    EA  AG DIIMLDNM+   + +A+ LI  R+  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS--  242

Query  241  VKIEASGGVRLDTIREIAATGVDIISVGGLTYSFDSLDISL  281
             +IE SG + + TI  + + ++D +S G+LT S  SLD+S+
Sbjct  243  -RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

579) Bcav_2774 in NC_012669


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (518),  Expect = 5e-35, Method: Compositional matrix adjust.
 Identities = 117/279 (42%), Positives = 185/279 (67%), Gaps = 5/279 (1%)

Query  2    LTRAQIERVVGAALEEDAPWGDLTSESLvpadavahaalvaREPGVMAGAEVFAVAMTAP  61
            LT  QI+  + AAL ED    D +++++   ++ A  +L A+E+GV+AG  VF    T  
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTL-  66

Query  62   ALGGDVVVTA--QVADGAAFGPGDVLAEVRGParavlraervalnllQRMCGIATLTRRY  119
             ++++V      Q  DG  + +GD++ E+ G+ R++L  ERVALN+LQ++ GIA++T  Y
Sbjct  67   -FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  120  VDAVAGTAARVTDTRKTTPGLRALERHAVRCGGGHNHRFSLSDAVLAKDNHLALAGDITA  179
            V+A+++   +V DTRKTTP LR +E+ AVR GGG NHRF+LSDA++ KDNH+A  G +  
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  180  VLVRARAALPHTTHIEVEVDRLDQIEPVLASGVVGTVMLDNFSLEDLRAGVALIAGRALV  239
             + +ARA  P    +EVEV+ L   E   A+G V+ +MLDN SLE++  +++LIAGR+ +
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAG-VDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  240  EASGGITLEDVAAVAATGVDLVSVGALTHSARALDLGLD  278
            E SG I +  ++   + ++D VS G+LTHSA++LD+++ 
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

580) Daro_2380 in NC_007298


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (518),  Expect = 5e-35, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 184/278 (67%), Gaps = 11/278 (3%)

Query  12   EISRNVDAALSEDVGAGDLTATLVPAER-QVRATVISREAGVLCGTAWFAECVARLDPTA  70
            +I   + AAL EDV + D ++  +  ++ Q + +++++EAGVL G + F    + +D+  
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE-  70

Query  71   RITWHGA----DGDRIAPNQLLCEIDGNGRALLTAERSALNFLQLLSAVASKARVYADAI  126
             +T + +    DGDR+++ +L+ EI G+ R+LLT ER ALNFLQ LS++AS +  Y +A+
Sbjct  71   -VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  127  TGTKAQVVDTRKTLPGLRIAQKYAVRAGGGGNHRLALWDAILIKENHIHaaggiaqamaa  186
             + + +V DTRKT P LR+ +KYAVR GGG NHR+ L DAI++K+NHI A G++ +A+A 
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  187  akqvaeqakgRCKFIQIEVESIDELNQALTAGATMILLDNFSLDMMREAAQINAGRAILE  246
            A+  A       K +++EVES+   ++A +AG  +I+LDN SL+ + +A  + AGR+ +E
Sbjct  190  ARAYAPFV----KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  247  ASGNVTLETIRGIAETGVDRISVGALTKDVKALDLSMR  284
             SGN+ + TI  +   ++D +S G+LT   K+LD+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

581) Mic7113_2515 in NC_019738


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (518),  Expect = 6e-35, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 172/273 (64%), Gaps = 14/273 (5%)

Query  24   EDIGRGDRTTASLFASGSQTAKAQWIAKESGVIAGLPIAARVFQLLNPQVQFI--PLIEE  81
            ED+   D +T ++F   +Q AK   +AKE+GV+AGL +  RVF L++++V F     + +
Sbjct  23   EDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKD  81

Query  82   GSWCESLPEMPSERRPVIATIEGPLDALLTGERVALNLAMGLSGIATLTHKYVAQIADLP  141
            G +      + S    ++  I G++ +LLT ERVALN+   LSGIA++T  YV  ++D  
Sbjct  82   GDR------LTSG--DLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  142  TQLVDTRKTTPGLRLLEKYATQVGGAVNHRMGLDDGVMIKDNHiaaaggignaiTQIRDR  201
             ++ DTRKTTP LRL+EKYA +VGG+ NHR  L D++M+KDNHIAA G++ +AI+Q R  
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  202  IPYPLTIEVETETLAQVREALEHQADIIMLDNMPLEMMRQAVQiirennnrikieASGNI  261
             P+   +EVE E+LA   EA     DIIMLDNM+LE + QA+        R +IE SGNI
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAI---TLIAGRSRIECSGNI  250

Query  262  TLETIRAVAETGVDYISSSAPITRSPWLDLSMR  294
             + TI      ++DY+SS++    +  LD+SM+
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

582) Noca_0463 in NC_008699


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (518),  Expect = 6e-35, Method: Compositional matrix adjust.
 Identities = 91/213 (43%), Positives = 140/213 (66%), Gaps = 3/213 (1%)

Query  83   AVEVTDRVPDGTRVAPGDVVMRVAGPTRGLLTAERTALNYASHLSGVATATAHWVDALAG  142
            + +  ++  DG R+++GD+V+ + G+ R+LLT ER ALN+  HLSG+A+ TA  V+AL++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  143  TRARVLDTRKTLPTFRALQKYAVRCGGGVNHRFSLGDRAMVKDNHVVAAGGVVPAYDAVR  202
             R +V+DTRKT P +R ++KYAVR GGG NHRF+L+D  M+KDNH+ A G+V  A     
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-  190

Query  203  RAYPDL--RVEVEVTGLDELRELLDAGCTEILLDNMDTATMAEAVRLTAGRATLEASGGL  260
            RAY+ +   VEVEV +L    E   AG   I+LDNM    + +A+ L AGR+ +E SG +
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  261  TIERAREVAETGVDFISVGALTHSVQVFDLGLD  293
             +         ++D++S G+LTHS + +D+++ 
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

583) Snov_0492 in NC_014217


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (517),  Expect = 6e-35, Method: Compositional matrix adjust.
 Identities = 94/222 (43%), Positives = 153/222 (69%), Gaps = 3/222 (1%)

Query  63   FELIDPSLSIVVER--RDGTSVGPGDVVMRLNGSARAILTAERVALNIACRMSGVATATA  120
            F L+D+ +++   +  +DG  + +GD+V+ + GS R++LT ERVALN+  ++SG+A+ TA
Sbjct  64   FTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTA  123

Query  121  GLVEIARQHGKAHIVCTRKTTPGLRALEKHAVKAGGGSNHRFGLDDAVLIKDNHIAVAGG  180
            + VE A  +++  +  TRKTTP LR +EK AV+ GGG NHRF L DA+++KDNHIA  G+
Sbjct  124  AYVE-ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  181  VAPAIRAAKANAGHMVKIEVEVDTLNQLEEAMAEGVDAVLLDNMTPPVLKEAVSIVGGRA  240
            V  AI  A+A A  +  +EVEV++L   EEA A GVD ++LDNM+   + +A+++++GR+
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  241  LTEASGRVSRETVGPIAASGVDLISVGWITHSAPILDLGLDA  282
              E SG +   T++ + + ++D +S G +THSA  LD+++ +
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

584) nadC in NC_003910


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (517),  Expect = 6e-35, Method: Compositional matrix adjust.
 Identities = 108/258 (42%), Positives = 179/258 (70%), Gaps = 7/258 (2%)

Query  40   TAMLIPENEQAVATVITREDCIVCGVAWVNEVFKQLDASLNRTVEQATKITWFVNDGESV  99
            T  ++ ++ QA  +++++E  ++ G++  + VF  +DA +  T +++ ++    +DG+ +
Sbjct  32   TNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV--TFQNPHQF----KDGDRL  85

Query  100  AANSTLFELEGDARTLLTGERVALNFLQTLSGTATLTSHYVKELAGSETKLLDTRKTLPG  159
            ++   ++E+ G  R+LLT ERVALNFLQ LSG A++T+ YV  L++   K++DTRKT P 
Sbjct  86   TSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPN  145

Query  160  LRSAQKYAVLCGGGVNHRIGLFDAFLIKENHIAACGGISQAVATAKSNHS-DKTveveve  218
            LR  +KYAV  GGG NHR+ L DA+++K+NHIAA G++ +A+A A++  +  K VEVEVE
Sbjct  146  LRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVE  205

Query  219  SLDELEQALNAGADIIMLDNFTPEMIEQAVTATRGKAKLEVSGNMTIEILQKYAKAGVDY  278
            SL   E+A  AG DIIMLDN + E IEQA+T   G++++E SGN+ +  + ++   ++DY
Sbjct  206  SLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDY  265

Query  279  ISSGALTKHVNAIDLSMR  296
            +SSG+LT   +++D+SM+
Sbjct  266  VSSGSLTHSAKSLDFSMK  283

585) Ser39006_3855 in NC_022268


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  141 bits (517),  Expect = 6e-35, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 175/272 (65%), Gaps = 11/272 (4%)

Query  30   ALCEDLGGEVDVQQDITALLLPDDKSATAVIITREAGIFCGQHWLEEVFHQLGDQVSVEW  89
            +L   L  +V+ ++  T  ++ ++  A   ++++EAG++ G   ++ VF  ++ +V+ + 
Sbjct  16   TLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  90   ---YVKDGSLLTENQPLCRLQGPSRQLLTGERTALNFLQTLSGIATEVSRYVKLLAGTHT  146
               + KDG  LT  + +  + G+ R LLT ER ALNFLQ LSGIA+  + YV  L++ + 
Sbjct  76   PHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  147  QLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIAAGSIRQAVEQAFQLR  206
            +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+ QA   R
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA---R  191

Query  207  SDVP----VEVEVETLDELQQALDAGADIVMLDNFSLEKIREAVRLAQGRVLLEVSGNVT  262
            +  P    VEVEVE+L   ++A  AG DI+MLDN SLE+I +A+ L  GR  +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  263  LKTLRDYAETGVDYISVGALTKHVHALDLSMR  294
            + T+  +   ++DY+S G+LT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

586) Sfum_0193 in NC_008554


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (513),  Expect = 1e-34, Method: Compositional matrix adjust.
 Identities = 120/271 (45%), Positives = 191/271 (71%), Gaps = 2/271 (0%)

Query  3    QLDVLLRMALVEDVGHGDVTTEGTIDAGLTGRAVVFGREPLVLSGSDPFRRTFRLVDPQV  62
            Q+D  L+ AL EDV   D +T++ +D    ++  +F++E+ VL+G   F+R F L D++V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  63   RVES--LFSDGEEVPADVPFFRMEGSVRSLLTAERTALNLLQRLSGVATLTRRMVNALAG  120
              ++   F DG+ + ++   + + GSVRSLLT ER ALN+LQ+LSG+A++T   V+AL++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  121  TSCRLLDTRKTTPLWRVLEKAAVRHGGGSNHRFGLFDGVLIKDNHvaavggvreavrrar  180
               +++DTRKTTP  R++EK AVR GGG NHRF L D++++KDNH+AAVG+V+ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  181  rSAPHGLKIevevetleqleealqaGADIILLDNFTLDLLQRAVAINAGRALLEASGGVT  240
              AP    +EVEVE+L   EEA  AG DII+LDN +L+ +++A+++ AGR+ +E SG + 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  241  LERVRVIAETGVDFVSCGALTHSAPAVDITM  271
            +  +  +   ++D+VS G+LTHSA ++D++M
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

587) nadC in NC_013260


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (513),  Expect = 1e-34, Method: Compositional matrix adjust.
 Identities = 115/274 (42%), Positives = 170/274 (63%), Gaps = 7/274 (2%)

Query  12   EALKRFLEEDIGRGDVTTLAIVPSDQKAIGHFMAKAPLVLAGIELVIDVLTLLDEGVVVE  71
            ++LK  L ED+   D +T AI   + +A   + AK + VLAG+ +   V+TL+D  V  +
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  72   HRRH--DGDELREGDRAASVRGQARALLTGERVATNLLQRLCGIATLTQRFVEAVRGTQA  129
            + ++  DGD L  GD    + G  R+LLT ERVA N+LQ+L GIA++T  +VEA+ + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  130  KILDTRKTTPGLRVFEKYAVTVGGGINHRFGLDDAILVKDNHIRLAGGISAAIEAARQHE  189
            K++DTRKTTP LR+FEKYAV VGGG NHRF L DAI++KDNHI   G++  AI  AR   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  190  SRSHRFevevttleelQEALRYDLDAVLLDNMHPEMVRQAVACVRTHERGRKITVEASGG  249
            +     EVEV +L   +EA   ++D ++LDNM  E + QA++ +  + R     +E SG 
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR-----IECSGN  249

Query  250  MTLDNVRTFAEAGVDWISIGALTHAAPAPDMSFK  283
            + +  +  F   ++D +S G+LTH+A + D S K
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

588) nadC in NC_017034


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (516),  Expect = 7e-35, Method: Compositional matrix adjust.
 Identities = 104/237 (44%), Positives = 158/237 (67%), Gaps = 10/237 (4%)

Query  37   KEEGVLAGLEEACAVFR----HLGLTTATSFVDGQPLKKGDVVLEVRGSARDMMRGERLA  92
            KE GVLAGL     VF     ++ +  +  F DG+ L  GD+VLE+ GS R ++  ER+A
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  93   LNFLGRMSGIATLTAKCI-SLAPG-VRIAATRKTTPGFRKFEKKAVKLAGGDAHRYDLSS  150
            LNFL ++SGIA++TA  + +L+ + +++  TRKTTP +R FEK AV+++GG  HR++LS 
Sbjct  109  LNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSD  168

Query  151  AVMIKDNQIRVMG-LESAIREAKRSASFTKKIEVEVESIEDAEKAARLGVDIIMFDNMKP  209
            A+M+KDN+I  +G ++ AI +A+  A+F K +EVEVES+  AE AA  GVDIIM+DNM  
Sbjct  169  AIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSL  228

Query  210  ATIKEGVKKVKAIDARILLEASGGITLENLADYARTGVDAISLGALTRDARWLDFSM  266
              I ++   +  I +R  +E SG I +  ++ +   ++D +S G+LT+ A+ LDFSM
Sbjct  229  EQIEQA---ITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

589) nadC in NC_012115


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (515),  Expect = 7e-35, Method: Compositional matrix adjust.
 Identities = 115/275 (42%), Positives = 172/275 (63%), Gaps = 11/275 (4%)

Query  4    QIIDFLKNALNEDIGRGDLARRLI---NKNAKAFIRAKSSGVVAGIE-YIKHFSDL-ADV  58
            QI D LK AL ED+   D +   I   + +AK  + AK +GV+AG+  + + F+ + A+V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  59   KFD--FNFQDGDLYKEGDIILEIYGNAKDLLSIERTMLNILQHASGIASNAYEFVK-LTE  115
             F+   +F+DGD    GD++LEI G+ + LL+ ER  LN+LQH SGIAS +  +V  L +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  116  GKLKILDTRKTRPGLRIFEKYAAFCGGVTNHRLGLDDCLMLKDTHLALFNSIEEAVKIAR  175
            +++K++DTRKT P LR+FEKYA   GG  NHR+ L D +MLKD H+A   S++ A+  AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  176  ENIPFTTKIEIEAETVQMAKDAMRAGADIVMCDNMSFDEIKEVVEFRNENFKGVFLEASG  235
               PF   +E+E E++  A +A  AG DI+M DNMS+++I + + +     +   +E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSG  248

Query  236  NVTLENIKNYVQTGIDAVSSGAIIHQATFKDFSMK  270
            N+ +  I  +   +ID VSSG++ H A   DFSMK
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

590) nadC in NC_008611


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (516),  Expect = 7e-35, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 177/272 (66%), Gaps = 5/272 (1%)

Query  13   ETIRRGLDEDLRYGPDVTTIATVPADATATASMVPREAGVIAGVDVALMVLDEVIGKDGY  72
            +T++ +L ED++ + D +T A    ++ A  S+ ++EAGV+AG+ V   V+    +   +
Sbjct  15   DTLKAALREDVH-SEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTF  73

Query  73   QVLGRVDDGARLQTGEPVLTIRAQTRGLLTGERTMLNLVCHLSGIATATAAWVEAVHGTK  132
            Q   +  DG RL +G+ VL I +  R+LLT ER  LN++ HLSGIA+ TAA VEA+ + +
Sbjct  74   QNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR  133

Query  133  AKIRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVAAAGSvlealravraa  192
             K+ DTRKT P LR ++KYAVRVGGG NHR+ L+DA ++KDNH+AA GSV  A+   RA 
Sbjct  134  IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY  193

Query  193  aPDLP-CEVEVDSLEQLDEVLPEKPELILLDNFPVWQTQTALQRRDSRAPTVLLESSGGL  251
            AP +   EVEV+SL   +E  +   ++I+LDN ++ Q + A+    +R+    +E SG +
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNI  250

Query  252  SLDTAATYAATGVDYLAVGALTHSVRVLDIGL  283
             + T + + + ++DY++ G+LTHS + LD+++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

591) Nwat_2243 in NC_014315


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (516),  Expect = 7e-35, Method: Compositional matrix adjust.
 Identities = 95/235 (41%), Positives = 157/235 (67%), Gaps = 3/235 (1%)

Query  41   RETAILCGTAWFNEVFRQLDASITVDWTK--TDGDPIFAHQVICTLHGLARPLLSGERTA  98
            +E+++L G + F+ VF  +DA +T +      DGD + + +++  + G  R+LL+ ER A
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  99   LNFLQTLSGTATITHRYVSALEGLPVSILDTRKTLPGLRQAQKYAVRCGGGHNHRHGLYD  158
            LNFLQ LSG A++T  YV AL +  + ++DTRKT P LR  +KYAVR GGG NHR  L D
Sbjct  109  LNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSD  168

Query  159  GILIKENHILAADSITAAVAQARTTNSNLP-VEIEVENLDELQQALTAGADILLLDNFDI  217
            +I++K+NHI A +S+  A+AQAR+  + +  VE+EVE+L   ++A +AG DI++LDN  +
Sbjct  169  AIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSL  228

Query  218  PLLQEAVQLTQRRAKLEASGGITLENVRQVAETGVDYISVGALTKDVRAVDLSIR  272
              +++A+ L   R+++E SG I +  + +    ++DY+S G+LT   +++D+S++
Sbjct  229  EQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

592) nadC in NC_013665


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (515),  Expect = 8e-35, Method: Compositional matrix adjust.
 Identities = 108/240 (45%), Positives = 162/240 (68%), Gaps = 10/240 (4%)

Query  34   IICKEEGVLAGLEEACAVFRHLGLSVG----SDLVDGQPVRKGDIILEARGSARDLMRGE  89
            ++ KE GVLAGL     VF  ++  V      ++ DG+ +  GD++LE  GS R L+  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  90   RLALNFLGRMSGIATLTAKCV-GLAPG-VRVAATRKTTPGFRKFEKKAVKLGGGDTHRYD  147
            R+ALNFL ++SGIA++TA  V +L+ + ++V  TRKTTP +R FEK AV++GGG  HR++
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  148  LSSAVMIKDNQIRIMG-LENAIREAKKVASFTKKIEVEVESLEDAEKAARAGADIIMFDN  206
            LS A+M+KDN+I  +G +++AI +A+  A+F K +EVEVESL  AE AA AG DIIM+DN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  207  MKPAMIKKGVKIVKSVDERILLEASGGITLSNISEYAKTGVDVISLGALTRDARWLDFSM  266
            M    I +++ ++ +   R  +E SG I ++ IS +   ++D +S G+LT+ A+ LDFSM
Sbjct  226  MSLEQIEQAITLIAG---RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

593) nadC in NC_007651


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (515),  Expect = 8e-35, Method: Compositional matrix adjust.
 Identities = 95/230 (42%), Positives = 153/230 (67%), Gaps = 3/230 (1%)

Query  65   LCGVPWFDAVVRAVDPSIEVD--WRYREGDRMTADSTVCELRGPARSLLTAERNALNFLQ  122
            L G+  F+ V    D+ +  +   ++++GDR+T++  V E+ G+ RSLLT ER ALNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  123  LLSGVATATRRYVDRIADTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLALYAGILIK  182
             LSG+A+ T  YV+ ++D R +++DTRKT P LRL +KYAVRVGGG N+R+ L  +I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  183  ENHIAAAGGVGEaldaafalnaaVP-VQIEVETLDQLRTALAHGARSVLLDNFTLDMMRD  241
            +NHIAA G+V  A+  A A  + V  V++EVE+L     A A G   ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  242  AVRITEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRAIDYSMR  291
            A+ +  GR+ +E SG ++  T+  +   ++D +S G+LT   +++D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

594) Hipma_1555 in NC_015318


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (515),  Expect = 8e-35, Method: Compositional matrix adjust.
 Identities = 113/277 (41%), Positives = 178/277 (65%), Gaps = 5/277 (1%)

Query  1    MNPVFIEKSLKAFLLEDAYFSDITTESL-SQNkkakaiikakEDFILAGAVFLNSLFKLM  59
            + P  I+ +LKA L ED    D +T+++  ++ +AK  + AKE  +LAG   ++ +F L 
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   END--FKIS-LFKQDGELVKKGECIAEVESTDRAILYIERTCLNLLQRLSGIATKARKFA  116
            + +  F+ +  FK DG+ +  G+ + E+ ++ R++L  ER  LN+LQ+LSGIA+ +  + 
Sbjct  68   DAEVTFQNPHQFK-DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  117  QLLEPYKAKITDTRKTTPGLRFFEKYAVKIGGGVNHRMGLFDAVLIKDNHIKAVGSIKRA  176
            + L   + K+ DTRKTTP LR+FEKYAV++GGG NHR  L DA+++KDNHI AVGS+++A
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  177  IELARRNVSFTTKIEIECSDLEQVRQAIEAKADIVMLDNMSIGQMKEALNLFKGEAIFEA  236
            I  AR   +F   +E+E   L    +A  A  DI+MLDNMS+ Q+ +A+ L+ G + +E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  237  SGNITEENVQDVAKTGIDFISSGSIIHHACWVDINMK  273
            SGNI    +      +ID++SSGS+ H A  +D++MK
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

595) nadC in NC_020055


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (515),  Expect = 9e-35, Method: Compositional matrix adjust.
 Identities = 109/269 (41%), Positives = 171/269 (64%), Gaps = 4/269 (1%)

Query  21   TIRIALSED--GPDLTSQGLFEPEDIATAQIIAKEDTVVAGLPLINLILEFADQENKCQV  78
            T++ AL ED  + D +++++F+ ++ A   ++AKE  V+AGL +++ ++ + D E   Q 
Sbjct  16   TLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  79   HLNVDEGEKISTGTLIAAIQGPAALLLKAERVILNFISHMSGIATETRKYVQALDHCETI  138
              +  +G+++++G L+  I G+   LL  ERV LNF+ H+SGIA+ T  YV+AL++    
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  139  LLDTRKTLPGLRYPEKYAVLVGGAKNHRLNLVEMLMLKDNHIDRAGSITLAVNKLRNKYE  198
            ++DTRKT P LR  EKYAV VGG+ NHR+NL + +MLKDNHI   GS+  A+ + R  Y 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA-YA  194

Query  199  E-CPPIEVECRTQEEVDEAVACKVDRIMLDNMTFDEAKASIATIPDEIETEISGNVTLET  257
                 +EVE  +    +EA A  VD IMLDNM++++   +I+ I++    E SGN+ + T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  258  IAGLAEAGPDYISVGRITHSAKCSDMSMK  286
            I+ +   + DY+S G +THSAK  D SMK
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

596) Thivi_3094 in NC_018012


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  140 bits (515),  Expect = 9e-35, Method: Compositional matrix adjust.
 Identities = 110/271 (41%), Positives = 184/271 (68%), Gaps = 4/271 (1%)

Query  26   IESQIDAALAEDMGAGDL-TAALLPAGQRARAELITREPATLCGCAWFETVFRRLDPASV  84
            I+  + AAL ED+ + D  T A++    +A+  L+++E++ L G + F+ VF  +D+   
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  85   IR--WEAEDGDRIVPGQRLCVLEGASRALLTGERTAMNYLQALAGTATRARQYADAVAGL  142
            ++   +  DGDR+ +G+ +  + G+ R+LLT ER A+N+LQ L+G A+ +  Y +A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  143  PVRVLDTRKTLPGLRLQQKYAVLCGGCHNHRIGLFDAILIKENHIlaagsiraaleaara  202
             ++V+DTRKT P LRL +KYAV  GG  NHR+ L DAI++K+NHI A GS++ A+  ARA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  203  lnaGVG-IEIEVESLAELEQALDAGAELVLLDNFTLEELRRAVALNAGRARLEASGGIDL  261
              + V  +E+EVESLA  E+A  AG ++++LDN +LE++ +A++L AGR+R+E SG ID+
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  262  KTVRPIAETGVDRISVGALTKDVTAVDLSMR  292
             T+  +   ++D +S G+LT    ++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

597) Cyan7425_2495 in NC_011884


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (512),  Expect = 1e-34, Method: Compositional matrix adjust.
 Identities = 116/272 (43%), Positives = 172/272 (64%), Gaps = 9/272 (3%)

Query  21   IREDLGRGDRTTQAICADPAHREPWGQATIEVKQAGIIAGLPLALRVFQRLDQTV--QAN  78
            +RED+   D +T+AI  + ++    ++ ++  K+AG++AGL +  RVF  +D  V  Q  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQ----AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  79   PQVKDGTSCKSGTVVAQLKGDLSTLLMGERVALNLLMRLSGIATLTRHYTDQLADLPTCL  138
             Q KDG    SG +V ++ G + +LL  ERVALN+L +LSGIA++T  Y + L+D    +
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  139  VDTRKTTPGLRLLEKYATAVGGAVNHRFGLDDAVMIKDNHilaaggigaaiDRVRQSAPF  198
             DTRKTTP LRL+EKYA  VGG+ NHRF L DA+M+KDNHI A G++  AI + R  APF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  199  PltievetetleqvqtALEHRADIIMLDNMPLDRMQAAVQLIRQQNAQIKIEASGNITLE  258
               +EVE E+L   + A     DIIMLDNM+L++++ A+ LI    ++ +IE SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMT  253

Query  259  NLRSVATTGVDYISTSALITRAPWLDCSLSIL  290
             +      ++DY+S+++L   A  LD S+  L
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

598) Ahos_2096 in NC_015518


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (511),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 104/239 (44%), Positives = 154/239 (65%), Gaps = 10/239 (4%)

Query  39   SKDEGVLAG-NKFIIPFLNY---LGFNVKSSMTDGVEVKKGDNLLVFEGEADKSLSVERL  94
            +K+ GVLAG   F   F  +   + F+      DG  +  GD +L + G     L+ ER+
Sbjct  48   AKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERV  107

Query  95   VLNLLGKLSGIA--TATYTMVKLAREVNPTVRIAGTRKTTPGLRVFEKYAIEVGGGDPHR  152
             LN+L  LSGIA  TA+Y +  L+ +    +++ +TRKTTP LR+FEKYA+ VGGG  HR
Sbjct  108  ALNFLQHLSGIASMTAAY-VEALGDD---RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  153  FNLSDAVLIKDNHLAIIGDIEKAVKMARQIASFTKKIEIEVSSYEDAIKAYRAGVDAILL  212
            FNLSDA+++KDNH+A +G ++KA+  AR  A+F K +E+EV S   A  A  AGVD I+L
Sbjct  164  FNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIML  223

Query  213  DNMSVNEIEEVVSELKGKVLLEASGRITPENVKSYAKTGVDIISSGYITHSSRSLDFSM  271
            DNMS+++IE+ ++ + G+  +E SG I    +  +   ++D +SSG +THS++SLDFSM
Sbjct  224  DNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

599) nadC in NC_020409


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (511),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 114/270 (43%), Positives = 171/270 (64%), Gaps = 6/270 (2%)

Query  20   ATIRIALAED--GSDLTSMGLFSENDMAQALIVAKQKTVVAGLPIIPLVLE-FGGE-DCQ  75
             T++ AL ED  + D ++ ++F +++ A+  + AK+  V+AGL ++  V+  F++E   Q
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  76   VHLNVDDGETVSEGTMVAALQGPATQILKAERVILNFLCHLSGIANMTAQYVEALEGTGV  135
               +  DG+ ++ G +V  + G+   +L  ERV LNFL HLSGIA+MTA YVEAL +  +
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  136  QLLDTRKTLPGLRFPEKYAVLAGGAKNHRMTLSEMLMLKDNHIDRAGSITHAVETLLRTN  195
            +++DTRKT P LR+ EKYAV  GG+ NHR  LS+ +MLKDNHI   GS+  A+    R+ 
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ-ARAY  193

Query  196  SP-CPPIEVECRTFAEVEEACQCQIQRIMLDNMDAKTAKEALTLIPDSIESEISGNVSLD  254
            +P    +EVE  ++A  EEA    ++ IMLDNM      +A+TLI++    E SGN+ + 
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  255  TIREIAGSGPDFISVGKLTHSAPSSDFSMQ  284
            TI  + G + D++S G LTHSA S DFSM+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

600) Mthe_0241 in NC_008553


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (510),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 106/247 (43%), Positives = 164/247 (67%), Gaps = 12/247 (4%)

Query  28   NVDAAIISKEDCILAGLEEVSELFEYLDVN----SEPLFDDGEYATAGAEVMSIQGSARN  83
            +   ++++KE  +LAGL     +F  +D +    +   F DG+  T+G  V+ I GS R+
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  84   ILRGERVALNILGRMSGIATLTRECV--LRAQKVRVACTRKTTPGFRYFEKKAVLIGGGD  141
            +L  ERVALN+L ++SGIA++T   V  L  ++++V  TRKTTP +R FEK AV +GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  142  THRFNLSGAVMIKDNHIAIMG-LEDAIKEARKRASFTKMIEVEVEDLDTMIRAAELGADI  200
             HRFNLS+A+M+KDNHIA +G ++ AI +AR  A+F KM+EVEVE L +   AA  G DI
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  201  IMFDNMNPEEIKRGVAMLEEMGVRSGVILEASGGINPGNLEAYASTGVDVISMGALTRGA  260
            IM+DNM+ E+I ++++++     RS +  E SG I+   +  + + ++D +S G+LT++A
Sbjct  221  IMLDNMSLEQIEQAITLIAG---RSRI--ECSGNIDMTTISRFRGLAIDYVSSGSLTHSA  275

Query  261  RWMDFSM  267
            + +DFSM
Sbjct  276  KSLDFSM  282

601) nadC in NC_003552


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (511),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 104/244 (43%), Positives = 157/244 (65%), Gaps = 13/244 (5%)

Query  33   IFTKEDCTVAGISEAASIFIYFG----IQAETDFKDGDRLSKGDTIFRLRGGAISILRAE  88
            +F+KE   +AG++    +F  F+    +Q   +FKDGDRL+ GD ++ + G+  S+L  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  89   RLSLNFLGHLSGIATLTRNCVDAVRKHSESTRVACTRKTTPGIRKFEKLAVAAGGGDTHR  148
            R++LNFL HLSGIA++T   V+A+    +  +V  TRKTTP +R FEK AV  GGG  HR
Sbjct  106  RVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  149  FNLSDAVMIKDNHIKLMG-IETAIKAARK-SSFTRKIEVEVESAEDAVLAAKLGADIVML  206
            FNLSDA+M+KDNHI  +G ++ AI  AR  ++F + +EVEVES   A  AA  G DI+ML
Sbjct  164  FNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIML  223

Query  207  DNMQPEVIRETLALLEEKGLRKSVLVEASGGISPANLEGYAKTGVDVISMGSLIHKSRWI  266
            DNM  E I ++++L+  ++ R    +E SG I  + +  +   ++D +S GSL H ++ +
Sbjct  224  DNMSLEQIEQAITLIAGRS-R----IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  267  DISL  270
            D+S+
Sbjct  279  DFSM  282

602) Nther_2415 in NC_010718


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (511),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 114/268 (43%), Positives = 176/268 (66%), Gaps = 8/268 (2%)

Query  36   NNDLSSDNQGDHLNSST-FNQGEQGKQGTGMITAKEEGILAGSFVVTRVFQKLSDQINCQ  94
            +  L  D ++++ ++++ F++  Q+K +   + AKE G+LAG  V  RVF  +  ++  Q
Sbjct  18   KAALREDVHSEDYSTNAIFDHHGQAKVS---LFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  95   I--LIPDGQRVLSGQDIMQVTGPLAPILTAERLALNFYQRLSGIATETRKLVDLITPYSC  152
                + DG+R+ SG+ ++++ G++ ++LT ER+ALNF Q+LSGIA+ T   V+ +     
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  153  ELLDTRKTTPGLRPLEKYAVRMGGGTNHRMGLYDGVMIKDNHKKASGSITEAIRRVKNTV  212
             ++DTRKTTP LR +EKYAVR+GGG NHR  L D++M+KDNH  A GS+  AI + + + 
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR-AY  193

Query  213  GPMVK-ISVEATNQKEAEEAYQHGADIILLDNMSTNQLVQITKKLSGKVLLEASGNISSD  271
            +P VK + VE  +   AEEA   G DII+LDNMS +Q+ Q    ++G+  +E SGNI   
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  272  NISEIARTGVDYISSGSITHSAESLDLS  299
             IS +   ++DY+SSGS+THSA SLD+S
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFS  281

603) Daes_1717 in NC_014844


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (510),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 111/270 (42%), Positives = 169/270 (63%), Gaps = 6/270 (2%)

Query  20   ATIRIALAED--GSDLTSLGLFSESDMAQAMIVAKQDTVVAGLPIIPMVLE-FGGDQC-Q  75
             T++ AL ED  + D ++ ++F + + A+  + AK+  V+AGL ++  V+  F+++   Q
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  76   THLNVDDGERVSAGTMVAAVRGPAIQLLKTERVIMNFLCHLSGIANLTAQYVEALKGTKT  135
               +  DG+R+++G +V  + G+   LL  ERV +NFL HLSGIA++TA YVEAL + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  136  QLLDTRKTLPGLRFPEKYAVLAGGGKNHRLTLSDMLMLKDNHIDRAGSIAQAVSALLHAH  195
            +++DTRKT P LR+ EKYAV  GGG NHR+ LSD +MLKDNHI   GS+ +A++   +A 
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ-ARAY  193

Query  196  SPCPPievecrti-eeveeASQCEIQRIMLDNMDTETIRTALGIIPGTIETELSGNVSLE  254
            +P   +           EEA+   ++ IMLDNM  E I  A+ +I+G    E SGN+ + 
Sbjct  194  APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  255  NIRELAELGPGYISVGKLTHSAPSSDFSMQ  284
             I  +  L+ +Y+S G LTHSA S DFSM+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

604) ECENHK_03935 in NC_018405


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (510),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 114/275 (42%), Positives = 178/275 (65%), Gaps = 4/275 (1%)

Query  24   PASVAHALKEDLGGDVNADKDITAQLLPKETRSHAVIITREEGVFCGKRWVEEVFTQLAG  83
            P  + ++LK  L  DV+++   T  ++  + ++   ++++E GV+ G    + VFT + +
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  84   D-DVQVTWHVEDGDAITANQPLFELDGPSRVLLTGERTALNFVQTLSGVASEVRRYVDLL  142
            +   Q   +  DGD +T+ + ++E+ G+ R LLT ER ALNF+Q LSG+AS    YV+ L
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  143  AGTHTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEK  202
            ++ + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GSV++A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  203  AFWLHPD--vpvevevesleeleQAVKAGADIIMLDNFETEQMREAVKLTNGRAQLEVSG  260
            A +  +     VEVEVESL   E+A  AG DIIMLDN   EQ+ +A+ L  GR+++E SG
Sbjct  190  A-RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  261  NVTFDTIREFAETGVDYISVGALTKHVRALDLSMR  295
            N+   TI  F   ++DY+S G+LT   ++LD+SM+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

605) Bphy_0581 in NC_010622


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (512),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 109/271 (41%), Positives = 176/271 (65%), Gaps = 4/271 (1%)

Query  32   IARNVADALAEDVGSGDL-TGLLVPADEMRDARIIVREEAVLCGVPWFNEVMRRVDPRI-  89
            I   +  AL EDV S D  T  +   +      ++ +E +VL G+  F+ V    D+ + 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  90   -EAQWRYREGDRMTADSVVCTLRGPARALLTAERNGLNFLQMLSGVASATRKFADAIAHT  148
             +   ++++GDR+T++ +V  + G+ R+LLT ER +LNFLQ LSG+AS T  + +A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  149  RARVLDTRKTLPGLRLAQKYAVRVGGGANQRLALYDGILIKENHIaaaggvgaamqaaia  208
            R +V+DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K+NHIAA G+V  A+  A A
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  209  LNAGVS-IQIEVETLGQLESALAHGAQSVLLDNFSFDMMRDAVRITAGRAVLEVSGGVNL  267
              + V  +++EVE+L+  E A A G + ++LDN S++ + +A+ + AGR+ +E SG +++
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  268  DTIRLIAETGVDRVSVGSLTKDVRATDFSMR  298
             TI  +   ++D VS GSLT   ++ DFSM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

606) Theos_1009 in NC_019386


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (509),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 122/273 (45%), Positives = 184/273 (68%), Gaps = 3/273 (1%)

Query  8    PLFLEDALKAWLREDLGHGDLTTELLVPEGLGGEAVIRAKERGVVAGLWVAERVFRLLGP  67
            P+ ++D+LKA LRED+   D +T+ +  +   +   + AKE GV+AGL V +RVF L+++
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  68   -VRFQALveegrevgegaevarLE--GPLRAILMGERLALNLLQRLSGIATLARAYARAL  124
             V FQ   +        +    LE  G++R++L  ER+ALN+LQ+LSGIA+++ AY  AL
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  125  EGTKARLLDTRKTTPGLRALEKWAVRVGGGGNHRFGLFDGILIKENHIraaggvgeavrr  184
             + + +++DTRKTTP LR +EK AVRVGGG NHRF L D+I++K+NHI A G+V  A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  185  akaraPHHLKvevevttleeleealeaGADLILLDNFPLEALREAVGRVGGRVPLEASGN  244
            A+A AP    VEVEV +L   EEA  AG D+I+LDN +LE + +A+  ++GR  +E SGN
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  245  MTLERAWAAAEAGVDYISVGALTHSPKALDLSL  277
            + +         ++DY+S G+LTHS+K+LD+S+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

607) nadC in NC_018828


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  139 bits (509),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 186/273 (69%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGGLTHSARVLDIGLDS  301
              T +   + ++D ++ G+LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

608) ABK1_0077 in NC_017162


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

609) ACICU_00066 in NC_010611


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

610) BJAB0715_00084 in NC_021733


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

611) BJAB0868_00083 in NC_021729


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

612) ABZJ_00069 in NC_017171


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

613) nadC in NC_010400


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

614) ABTW07_0074 in NC_017387


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

615) nadC in NC_002928


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARVAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

616) Cpar_0276 in NC_011027


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 100/233 (43%), Positives = 157/233 (68%), Gaps = 11/233 (4%)

Query  64   VVKQVFQSTDPELEFTA--HVQDGKRVYPGEHILEVRGRIASILFGERTALNFMQRMSGI  121
            V ++VF   D+E+ F    + +DG R+ +G+ +LE+ G + S+L  ER ALNF+Q++SGI
Sbjct  59   VFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGI  118

Query  122  ATRTNMYVERVSHTNAAILDTRKTAPGLRYYDKDAVRIGGGTNHRFGLFDMILIKDNHID  181
            A+ T  YVE +++    ++DTRKT+P LR ++K AVR+GGG NHRF L D I++KDNHI 
Sbjct  119  ASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIA  178

Query  182  AAGSVDEAINRAKAYCKEHGVNVK-IETEVRSISELVRACTCRPDIILLDNFMVDDLAEA  240
            A GSV+ AI +A+AY    +  VK +E EV S++    A +   DII+LDN  ++++ +A
Sbjct  179  AVGSVQKAIAQARAY----APFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQA  234

Query  241  VRWVKANGYGDIRLEASGNINLHNVAEIALTGVDYISIGELTHSVKALDLSMK  293
            +  + + +    R+E SGNI++  ++ +   ++DY+S G LTHS K+LD+SMK
Sbjct  235  ITLIAGRS----RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

617) W5S_3900 in NC_017845


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (508),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 112/276 (41%), Positives = 183/276 (67%), Gaps = 7/276 (2%)

Query  22   DIPASVQLALREDLGGIVDANQDITALLLPDNETVSARIITREAGIFCGTRWLEEVFSQL  81
            +I  +++ ALRED    V++++  T  ++ ++      ++++EAG++ G   ++ VF+ +
Sbjct  12   QIDDTLKAALRED----VHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  82   GNTTTI--VWHVTDGEAITPNQTLCDITGPAKQLLTGERTALNFLQTLSGVATEVSRYVA  139
            +   T+    +  DG+ +T+ + + +I G+ + LLT ER ALNFLQ LSG+A+  + YV 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  140  ILQGtrtrlldtrktlPGLRTALKYAVSCGGGDNHRLGLSDAFLIKENHIIAAGSIKNAV  199
             L + R +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  200  EKAQALRNDVP-VEVEVESLNELQQALEAGADIIMLDNFSLDNIREAVGLTQGRALLEIS  258
             +A+A    V  VEVEVESL   ++A  AG DIIMLDN SL++I +A+ L  GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  259  GNVTLDTLRGYAETGVDYISVGALTKHVQALDLSMR  294
            GN+ + T+  +   ++DY+S G+LT   ++LD+SM+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

618) Aave_3851 in NC_008752


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (507),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 95/221 (43%), Positives = 152/221 (69%), Gaps = 6/221 (2%)

Query  74   LDPDVRL--TWRVAEGQRCTADQVVLEIEGQARALLSAERTALNFLQMLSAVATKTRRYV  131
            +D++V +    +  +G+R T++++VLEI G  R+LL+ ER ALNFLQ LS++A+ T  YV
Sbjct  67   FDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  132  DAVAGTRAQIVDTRKTLPGLRLAQKYAVRMGGGTNHRIGLHDAVLIKENHIAAAGGVTav  191
            +A+++ R ++ DTRKT P LRL +KYAVR+GGG NHR+ L DA+++K+NHIAA G+V   
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  192  lhaaraaaaqaKFIEIECETLEQLDEALSAGARMVLLDNMPLPMLHDAVRLNAAHPAGPA  251
            +  ARA A+  K +E+E E+L   +EA +AG  +++LDNM+L  +++A+ L     AG +
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL----IAGRS  242

Query  252  ILEISGGVTLEGLRALAETGVDRISIGTLTKDVKATDFSMR  292
             +E SG + +  +  +   ++D +S G+LT   K+ DFSM+
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

619) nadC in NC_011586


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (507),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDIKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

620) nadC in NC_011595


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (507),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDIKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

621) nadC in NC_010410


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (507),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 115/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDIKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

622) M3Q_276 in NC_018706


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 114/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGANIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG +I+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

623) FIC_02362 in NC_013062


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (507),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 113/271 (42%), Positives = 174/271 (65%), Gaps = 5/271 (1%)

Query  16   IKNALAEDIQEGDHSTLATIPKDLEQKAKLLVKEDCILAGAEMAEMIFNHFDKDLKMEV-  74
            +K AL ED++  D ST A +  + + K  L+ KE  +LAG  + + +F  FD ++  +  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  75   -LIKDGQSAKVGDIAFYVTGSARSILSTERLVLNCMQRMSGIATLTHDWDSRllgtktkl  133
              +KDG+    GD+ + + GS RS+L+ ER+ LN +Q++SGIA++T      L + + K+
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  134  ldtrkttPNFRICEKWAVAIGGGTNHRFGLYDMMMLKDNHIDYNGSIANAVKMAKEYSKD  193
            +DTRKTTPN+R+ EK AV +GGG NHRF L D +MLKDNHI   GS+ +A+  A+ Y+  
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  194  NKKKLKIEVETRNLDEVEQALKAGVDRIMLDNMDVPTMQKAVELIGGRCESEASGGITRD  253
             K    +EVE  +L   E+A  AGVD IMLDNM +  +++A+ LI+GR   E SG I   
Sbjct  197  VK---MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMT  253

Query  254  MLKSIAQTGVDYISAGALTHSAANIDLSLKA  284
             +  +   ++DY+S+G+LTHSA ++D+S+K+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

624) nadC in NC_019382


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

625) nadC in NC_018829


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

626) nadC in NC_002927


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

627) nadC in NC_018518


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

628) nadC in NC_017223


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

629) nadC in NC_002929


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  138 bits (506),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 117/273 (43%), Positives = 185/273 (68%), Gaps = 3/273 (1%)

Query  31   LEPLVRAALLEDLGRAGDITTDAIVPAQARAQTRLVARQAGVLAGLDLARLAFRLVDPEI  90
            ++  ++AAL ED+ ++ D +T+AI   +++A+  L A++AGVLAGL + +  F L D+E+
Sbjct  13   IDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  91   EFHA--LLPDGAQLQPGAEIALIRGPARGMLTAERTALNFLCHLsgvasatasivaaiga  148
             F+    + DG +L +G  +  I G+ R++LT ER ALNFL HLSG+AS TA+ V A+G 
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  149  gHTKVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHVAIAGGIDAAVQRAR  208
            ++ KV  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNH+A  G+++ A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  209  AAIGHMVKIEVEVDTLEQLRVALRlgvdvvlldnmdldtlREAVALVDGRAVTEASGRIT  268
            A    +  +EVEV++L     A   GVD+++LDNM L+ + +A++L+ GR+  E SG I 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  PETAPAVAATGVDLMAIGWLTHSARVLDIGLDS  301
              T +   + ++D ++ G LTHSA+ LD+++ +
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

630) BJAB07104_00082 in NC_021726


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (505),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 114/271 (43%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKH--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGL  128
                 +  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVTVGGGKNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV VGGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVKAVDLSMR  278
              +      ++DY+S G LT   K++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

631) nadC in NC_014323


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (505),  Expect = 5e-34, Method: Compositional matrix adjust.
 Identities = 114/271 (43%), Positives = 180/271 (67%), Gaps = 6/271 (2%)

Query  33   DANVNQAIAEDVGDCDYT--GLLVPESEFVKARVIVREAAVLCGAPWFEAVMTRLDP--R  88
            D  ++ A+ EDV   DY+  +++  +++  K  ++ +EA+VL G   F+ V T +D+   
Sbjct  14   DDTLKAALREDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  89   LQVSWRYAEGERMAADSEVCTIEGPARALLTAERGALNFLQLLSGVASATRRYVDVVQGT  148
            +Q + ++ +G+R++++  V  I G+ R+LLT ER ALNFLQ LSG+AS T  YV+ + + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  149  RASILDTRKTLPGLRLAQKYAVRVGGGVNQRLALYDGILIKENHiaaaggitaavaaaLK  208
            R  ++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K+NHIAA G++  A+A A  
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  209  LNAGVS-IQVEVESIDELKEALQAGARSILLDNFSLEMMREAVTVNAGRALLEASGGINM  267
              + V  ++VEVES+    EA  AG   I+LDN SLE + +A+T+ AGR+ +E SG I+M
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  268  QTVRAIAETGVDRISIGSLTKDVQATDFSLR  298
             T+  +   ++D +S GSLT   ++ DFS++
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

632) VCLMA_A2126 in NC_017270


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 6e-34, Method: Compositional matrix adjust.
 Identities = 112/269 (42%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGETLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELQGTQC  145
               + +DG+ LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

633) Acav_3759 in NC_015138


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (503),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 92/210 (44%), Positives = 146/210 (70%), Gaps = 4/210 (1%)

Query  73   HVAEGQRCAADQVVLEIEGQARALLSAERTALNFLQLLSAVATKTRRYVDAVAGTRAQIV  132
            +  +G+R +++++VLEI G  R+LL+ ER ALNFLQ LS++A+ T  YV+A+++ R ++ 
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  133  DTRKTLPGLRLAQKYAVRMGGGTNHRIGLHDAVLIKENHIAAAGGVTavlhaaraaaaqa  192
            DTRKT P LRL +KYAVR+GGG NHR+ L DA+++K+NHIAA G+V   +  ARA A+  
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  193  KFIEIECETLEQLHEALSAGARMVLLDNMPLPMLHEAVRLNAAHPAGPAILEISGGVTLE  252
            K +E+E E+L   +EA +AG  +++LDNM+L  +++A+ L     AG + +E SG + + 
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL----IAGRSRIECSGNIDMT  253

Query  253  GLRALAETGVDRISIGTLTKDVKATDFSMR  282
             +  +   ++D +S G+LT   K+ DFSM+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

634) O3Y_11600 in NC_016944


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

635) nadC in NC_012578


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

636) VCD_001933 in NC_012668


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

637) nadC in NC_016445


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

638) VC2422 in NC_002505


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

639) nadC in NC_012582


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

640) nadC in NC_009457


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 7e-34, Method: Compositional matrix adjust.
 Identities = 113/269 (43%), Positives = 179/269 (67%), Gaps = 3/269 (1%)

Query  28   DTLKEDLGGTLDPAADITASLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIE  87
            DTLK  L   +++    T +++  +  +  +++++EAGV+ G    + VF  ++++V+++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  88   --WHVQDGDTLTPNQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELKGTQC  145
               + +DGD LT+ + +  + G+ R LLT ER A+NF+Q LSG A+ TA YV+ L + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  146  RLLDTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLN  205
            +++DTRKT P LR   KYAV  GGGYNHR+ + DA ++K+NHI A G++++AI+ A+   
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  206  P-GKPvevetetlaeleeaISAGADIIMLDNFSLEMMREAVKINAGRAALENSGNITLDN  264
            P  K VEVE E+LA  EEA +AG DIIMLDN SLE + +A+ + AGR+ +E SGNI +  
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  265  LKECAETGVDYISVGALTKHLKALDLSMR  293
            +      ++DY+S G+LT   K+LD+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

641) nadC in NC_009348


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (502),  Expect = 8e-34, Method: Compositional matrix adjust.
 Identities = 104/242 (43%), Positives = 167/242 (70%), Gaps = 3/242 (1%)

Query  45   ASARVITREAGVFCGQPWVDEVFAQLGGEVKVE--WLVQDGEPLSPNQELFRLHGPARVL  102
            A   ++++EAGV+ G    + VF+ +++EV  +     +DG+ L++ + ++ + G+ R L
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  103  LTGERNALNFVQTLSGVATLTARYVAELAGTRCRLLDTRKTLPGLRTAQKYAVTCGGGKN  162
            LT ER ALNF+Q LSG+A++TA YV  L++ R +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  163  HRIGLYDAYLIKENHILACGGISEAITEAHRLNP-GKPveveveslaelaqallaGADIV  221
            HR+ L DA ++K+NHI A G++  AI++A+   P  K VEVEVESLA   +A  AG DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  222  MLDNFDVPMMREAVTLNQGRAKLEVSGNVTLDTLAEYAATGVDFISVGALTKHVRALDLS  281
            MLDN  +  + +A+TL  GR+++E SGN+ + T++ + + ++D++S G+LT   ++LD+S
Sbjct  222  MLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

Query  282  MR  283
            M+
Sbjct  282  MK  283

642) BUPH_03335 in NC_018695


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (503),  Expect = 8e-34, Method: Compositional matrix adjust.
 Identities = 97/238 (41%), Positives = 164/238 (69%), Gaps = 3/238 (1%)

Query  73   VIVREDAVLCGVPWFNAVLRQVDSRIEVH--WHYREGSRMTADTPVCELRGPVRALLTAE  130
            ++ +E +VL G+  F+ V+   D+ +  +   ++++G R+T++  V E+ G+VR+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  131  RNALNFLQLLSGVASATRRYVDAIAHTHTRILDTRKTLPGLRLAQKYAVRVGGGANQRLA  190
            R ALNFLQ LSG+AS T  YV+A+++ + +++DTRKT P LRL +KYAVRVGGG N+R+ 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  191  LYDGILIKENHIaaaggvgaamdaalaFNAGVS-IQIEVETLEQLQTALAHRAQSILLDN  249
            L D+I++K+NHIAA G+V  A+  A A+ + V  +++EVE+L   + A A   + I+LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  250  FSFDAMREAVRITAGRAVLEVSGGVNFETVRTIAETGVDRVSIGALTKDVRATDYSLR  307
             S++ + +A+ + AGR+ +E SG ++  T+  +   ++D VS G+LT   ++ D+S++
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

643) Hhal_2042 in NC_008789


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (503),  Expect = 8e-34, Method: Compositional matrix adjust.
 Identities = 113/281 (41%), Positives = 174/281 (62%), Gaps = 5/281 (1%)

Query  1    MTISLPPRETIRDDVARALAEDVGGGDL-TAGLVPASGVAEGQVVAREAAVLCGTAWFDE  59
            ++  L P + I D +  AL EDV + D  T ++    G A   + A+EA+VL G + F+ 
Sbjct  4    ISTDLTPFQ-IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  60   VFRQLDRGVGVR--WLCSDGEAVEPGAVVCRIQGPSRAVLTGERTALNFLQFLSGTATTA  117
            VF  +D  V  +      DG+ + +G +V  I G+ R++LT ER ALNFLQ LSG A+ +
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  118  RRYADAVAGTGVQLLDTRKTVPGLRAAQKYAVRAGGGSNHRFGLFDAYLIKENHIAACGG  177
              Y +A+++  ++++DTRKT P LR  +KYAVR GGG NHRF L DA ++K+NHIAA G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  178  LTPAVEVARLRAA-GTPITVEIEDLVQLDEAIAAGADVVMLDNFDADGIRQAVDRAAGRV  236
            +  A+  AR  A+    + VE+E L   +EA AAG D++MLDN   + I QA+   AGR 
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  237  ALEVSGGLDLDAVRALAATGVDRISVGALTKHVHALDLSLR  277
             +E SG +D+ ++  + + ++D +S G+LT    +LD+S++
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

644) PYCH_12720 in NC_015680


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (503),  Expect = 8e-34, Method: Compositional matrix adjust.
 Identities = 108/269 (41%), Positives = 179/269 (67%), Gaps = 15/269 (5%)

Query  11   IKEDAPFGDVTSEAIIPENMRAKAVVIAKQDGVIAGVEEAKALFEHFGVKVKVKK----R  66
            ++ED    D +++AI+ ++ +AK  ++AK+ GV+AG+   + +F  F+  V  ++    +
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  67   DGEEVKKGDVILELEGNARAILLVERTALNVMGRMSGIATQTRRLVEKVRKVNPKIMVAG  126
            DG+ +  GD++LE+ G+ R++L  ER ALN + ++SGIA+ T   VE +   + +I V +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFD  138

Query  127  TRKSL--LRLIDKRAIIIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIKRAKAFSVY-K  182
            TRK+   LRL++K A+ +GGG  HRF+LSDAI++KDNH+A V +++ AI +A+A++ + K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  183  VVEVEVENLEDALRAARAGADVIMLDNMRPEEVAEVIEALRKEGLRERVKLEVSGGITED  242
            +VEVEVE+L  A  AA AG D+IMLDNM  E++ + I +L    +  R ++E SG I   
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAI-TL----IAGRSRIECSGNIDMT  253

Query  243  NITEYARLDVDVISLGALTHSVKNFDVSL  271
             I+ +  L +D +S G+LTHS K++D S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

645) F7308_1483 in NC_015696


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (502),  Expect = 9e-34, Method: Compositional matrix adjust.
 Identities = 85/205 (42%), Positives = 145/205 (71%), Gaps = 1/205 (0%)

Query  81   YDDADKISAGEKIFELRGNARSILTAERAMLNFIQMLSATATATNNLVKLIADHKTKLLD  140
            + D+D++++G+ ++E+ G+ RS+LT ER  LNF+Q LS+ A+ T   V  ++D++ K++D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  141  TRKTIPCFRMAQKYAVTCGGGFNHRIGLFDAYLIKENHIRSAGGIAKAVSKAARLQP-TK  199
            TRKT P +R+ +KYAV  GGG+NHR+ L DA ++K+NHI + G++ KA+++A    P  K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  200  TIEVEVTNLDELNQAIQAGANIIMLDNFSIEDINKAVEIAKGKVALEVSGNIDSNSIVKM  259
             +EVEV +L   ++A  AG +IIMLDN S+E+I++A+ +  G+  +E SGNID  +I + 
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  260  AQTGVDFISVGAITKHITAIDLSMQ  284
               ++D++S G++T    ++D+SM+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

646) Strvi_8877 in NC_015957


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  137 bits (504),  Expect = 9e-34, Method: Compositional matrix adjust.
 Identities = 115/282 (41%), Positives = 189/282 (68%), Gaps = 3/282 (1%)

Query  58   LISAGLDPIQVEDVAHMAIEEDLDQGVDVTTVATVPEDAFATGDFTAREAGTVAGLRIAE  117
            +IS++L P+Q++D    A+ ED+ ++ D +T A   +++ A   + A+EAG +AGL + +
Sbjct  3    IISTDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  118  AILSVVCTD-EFEVERHAEDGDRVAAGQKLLSVRTRTRDLLTGERSALNLLCRLSGIATA  176
             ++++  ++  F+  ++  DGDR+++G+ +L +    R LLT ER ALN+L +LSGIA+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  177  TRAWADALDGtktkvrdtrkttPGLRALEKYAVRCGGGVNHRMSLSDAALVKDNHVIaag  236
            T A  +AL++ + KV DTRKTTP LR +EKYAVR GGG NHR +LSDA ++KDNH+ A G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  237  gvaeafgavraefPDVP-IEVEVDTLDQIPPVLEAGADLILLDNFTPERTREAVELVAGR  295
            +V  A++  RA  P V  +EVEV++L        AG D+I+LDN + E+  +A+ L+AGR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  296  AALESSGRLTLAGARTYAETGVDYLAVGALTHSSPILDIGLD  337
            + +E SG + ++    +   ++DY++ G+LTHS+  LD+++ 
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

647) mll6272 in NC_002678


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  136 bits (500),  Expect = 1e-33, Method: Compositional matrix adjust.
 Identities = 119/280 (43%), Positives = 190/280 (68%), Gaps = 6/280 (2%)

Query  2    NLSPLPVIMLEPLVRAALLEDLGRAGDVTTEAIVTPFHYARTVLAARQRGIVAGLDLAML  61
            +L+P+ +   +  ++AAL ED+ ++ D +T+AI      A+  L A++ G++AGL +   
Sbjct  7    DLTPFQI---DDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQR  62

Query  62   AFRLISPDVEILVERP--DGCSVVEGEVIASVVGPARAILTAERTALNFLCHLSGIATAT  119
             F L+ ++V +   +   DG  +  G+++  ++G+ R++LT ER ALNFL HLSGIA+ T
Sbjct  63   VFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT  122

Query  120  ASIVNAIRDHPVKITCTRKTTPGLRAVEKYAVRAGGGANHRFGLDDAILIKDNHiaiagg  179
            A+ V+A+ D+ +K+  TRKTTP LR  EKYAVR GGG NHRF L DAI++KDNHIA  G+
Sbjct  123  AAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGS  182

Query  180  iraaikrarasagHLVKIEVEVDtltqleealtltPDAVLLDNMSVDDLRQAVAMVAGRA  239
            ++ AI +ARA A  +  +EVEV++L+  EEA +   D ++LDNMS++++ QA++++AGR+
Sbjct  183  VQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS  242

Query  240  ITEASGRitaatapaiaatRVDLISIGWLTHSAPILDIGL  279
              E SG I  +T + + +  +D +S G LTHSA  LD+++
Sbjct  243  RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

648) Namu_3164 in NC_013235


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  136 bits (498),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 178/272 (66%), Gaps = 14/272 (5%)

Query  14   ALAEDLADGADVTTLATVPADQSVRAQLTPRQAGVLAGGPIAAQVFRTVIGSAVRVE--Q  71
            AL ED+ ++ D +T A    +   +  L +++AGVLAG  +  +VF T++++ V  +  +
Sbjct  20   ALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF-TLFDAEVTFQNPH  77

Query  72   LVPDGGTLVPGEPALIVHGPTAGILTAERTALNLLTHLSGIASATRTWVDAVAGTGARIR  131
               DG+ L +G+  L + G+  ++LT ER ALN+L HLSGIAS T + V+A+++   ++ 
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  132  DTRKTLPGLRALEKYAVRCGGGVNHRMSLGDAALIKDNHVAAAGSVTAAIKAVRALDPDI  191
            DTRKT P LR +EKYAVR GGG NHR +L+DA ++KDNH+AA GSV  AI   RA  P +
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  192  TL-EVEVDTLEQFDEAIGAGAELVLLDNFSLADTaeavlraralprrvYLEASGGL---T  247
             + EVEV++L   +EA +AG ++++LDN SL +  +A+    + +R   +E SG +   T
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTT  254

Query  248  LDRARAVARTGVDYLAVGALTHSAPALDLGLD  279
            + R R++A   +DY++ G+LTHSA +LD+++ 
Sbjct  255  ISRFRGLA---IDYVSSGSLTHSAKSLDFSMK  283

649) nadC in NC_016603


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  136 bits (498),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 111/271 (41%), Positives = 179/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VIWLKQ--EGERVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTTEYVQHLEGL  128
                 Q  +G+R+++ +  L + GS RSLLT ER ALNF+Q LS++A+ T+ YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  NTKLLDTRKTLPGLRIAQKYAVAIGGGQNHRLGLFDAFLIKENhimaaggiaqaiakahq  188
              K++DTRKT P LR+ +KYAV +GGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  iaP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVRAVDLSMR  278
              +      ++DY+S G LT   +++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

650) ENC_46200 in NC_021046


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  136 bits (499),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 115/283 (41%), Positives = 182/283 (65%), Gaps = 3/283 (1%)

Query  16   LERINSDI-PASVAHALKEDLGGDVSADNDITAQLLPKETRSHAVIITREAGVFCGKRWV  74
            +  I++D+ P  + ++LK  L  DV +++  T  ++  + ++   ++++EAGV+ G    
Sbjct  1    MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF  60

Query  75   EEVFTQLAGD-EVQVTWHVEDGDAVTANQPLFELDGPSRVLLTGERTALNFVQTLSGVAS  133
            + VFT + ++   Q   +  DGD +T+ + ++E+ G+ R LLT ER ALNF+Q LSG+AS
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  134  EVRRYVDLLAGTRTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLSDAFLIKENHIIAS  193
                YV+ L++ R +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A 
Sbjct  121  MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV  180

Query  194  GSVRQAVEKA-FWLHpdvpvevevetleeldeAIKAGADIIMLDNFDTEQMREAVKRTNG  252
            GSV++A+ +A         VEVEVE+L   +EA  AG DIIMLDN   EQ+ +A+    G
Sbjct  181  GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG  240

Query  253  QAQLEVSGNVTFDTIREFAETGVDYISVGALTKHVRALDLSMR  295
            ++++E SGN+   TI  F   ++DY+S G+LT   ++LD+SM+
Sbjct  241  RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

651) PCC21_035680 in NC_018525


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  136 bits (499),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 111/276 (41%), Positives = 183/276 (67%), Gaps = 7/276 (2%)

Query  22   DIPASVQLALREDLGGIVDANQDITALLLPDNETVSARIITREAGIFCGTRWLEEVFSQL  81
            +I  +++ ALRED    V++++  T  ++ ++      ++++EAG++ G   ++ VF+ +
Sbjct  12   QIDDTLKAALRED----VHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  82   GNTTTI--VWHVADGDAITPNQTLCDITGPAKQLLTGERTALNFLQTLSGVATEVSRYVA  139
            +   T+    +  DGD +T+ + + +I G+ + LLT ER ALNFLQ LSG+A+  + YV 
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  140  VLQGtrtrlldtrktlPGLRTALKYAVSCGGGDNHRLGLSDAFLIKENHIIAAGSIKNAV  199
             L + R +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  200  EKAQSLRSDVP-VEVEVESLDELQQALEAGADIIMLDNFSLDNIREAVNTTQGRALLEIS  258
             +A++  + V  VEVEVESL   ++A  AG DIIMLDN SL++I +A+    GR+ +E S
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECS  247

Query  259  GNVTLDTLRGYAETGVDYISVGALTKHVQALDLSMR  294
            GN+ + T+  +   ++DY+S G+LT   ++LD+SM+
Sbjct  248  GNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

652) A1S_0044 in NC_009085


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (495),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 108/246 (44%), Positives = 166/246 (68%), Gaps = 3/246 (1%)

Query  5    EDEQATATIISREDMVLAGQPWVNALISAYDNTVQVTWLKQ--EGDRVAANEAFLKLAGS  62
            ++ QA  +++++E  VLAG    + +++ +D  V      Q  +GDR+++ +  L + GS
Sbjct  38   HHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGS  97

Query  63   ARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGLNTKLLDTRKTLPGLRIAQKYAVTVG  122
             RSLLT ER ALNF+Q LS++A+ TA YV+ L +   K++DTRKT P LR+ +KYAV VG
Sbjct  98   VRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVG  157

Query  123  GGQNHRLGLFDAFLIKENhimaaggiaqaiakahqiaP-GKPVEVEVETWDELNQALEAG  181
            GG NHR+ L DA+++K+NHI A G++ +AIA+A+  AP  K VEVEVE+    ++A  AG
Sbjct  158  GGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAG  217

Query  182  ADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITIENLREVATTGVDYISMGVLTKDVKA  241
             DI+MLDN S +Q+ +A+  +AGR ++E SGNI +  +      ++DY+S G LT   K+
Sbjct  218  VDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKS  277

Query  242  VDLSMR  247
            +D+SM+
Sbjct  278  LDFSMK  283

653) Bxe_A0814 in NC_007951


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (497),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 101/238 (43%), Positives = 160/238 (68%), Gaps = 3/238 (1%)

Query  63   IIVREDAVLCGVPWFNAVMRQVDPRIEVQ--WRYREGDRMKADTTVCELRGPVRALLTAE  120
            ++ +E +VL G+  F+ V    D+ +  Q   ++++GDR+ ++  V E+ G+VR+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  121  RNALNFLQLLSGVASATRHYVDAVAHTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLA  180
            R ALNFLQ LSG+AS T  YV+A+++ R +++DTRKT P LRL +KYAVRVGGG N+R+ 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  181  LYDGILIKENHIaaaggvgaamnaala-lnagvPIQVEVETLEELEIALAHRAQSVLLDN  239
            L D+I++K+NHIAA G+V  A+  A A       ++VEVE+L   E A A   + ++LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  240  FSFEAMREAVRITAGRAVLEVSGGVNFDTVRTIAETGVDRVSIGALTKDVRATDYSMR  297
             S+E + +A+ + AGR+ +E SG ++  T+  +   ++D VS G+LT   ++ D+SM+
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

654) ECL_00905 in NC_014121


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (497),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 177/275 (65%), Gaps = 4/275 (1%)

Query  24   PASVAHALKEDLGGDVSADNDITAQLLPKETRSHAVIITREDGVFCGKRWVEEVFTQLAG  83
            P  + ++LK  L  DV +++  T  ++  + ++   ++++E GV+ G    + VFT + +
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  84   D-EVQITWHVEDGDAITANQPLFELEGPSRVLLTGERTALNFVQTLSGVASEVRRYVDLL  142
            +   Q   +  DGD +T+ + ++E+ G+ R LLT ER ALNF+Q LSG+AS    YV+ L
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  143  AGTHTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEK  202
            ++ + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GSV++A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  203  AFWLHPD--vpvevevenleeleQAIKAGADIIMLDNFETAQMREAVKLTNGQAQLEVSG  260
            A +  +     VEVEVE+L   E+A  AG DIIMLDN    Q+ +A+ L  G++++E SG
Sbjct  190  A-RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  261  NVTFETIREFAETGVDYISVGALTKHVRALDLSMR  295
            N+   TI  F   ++DY+S G+LT   ++LD+SM+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

655) nadC in NC_016514


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (497),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 112/274 (41%), Positives = 176/274 (65%), Gaps = 2/274 (0%)

Query  38   PASVAHALKEDLGGDVSADRDITAQLLPKETRSHAVIITREEGIFCGKRWVEEVFTQLAG  97
            P  + ++LK  L  DV ++   T  ++  + ++   ++++E G++ G    + VFT + +
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  98   DEV-QITWHVDDGDAITANQPLFELDGPSRVLLTGERTALNFVQTLSGVASEVRRYVDLL  156
            +   Q   +  DGD +T+ + ++E+ G+ R LLT ER ALNF+Q LSG+AS    YV+ L
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  157  AGTRTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEK  216
            ++ R +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GSV++A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  217  AFWLHP-DvpvevevenleeleQAIKAGADIIMLDNFETEQMREAVKLTNGKAQLEVSGN  275
            A    P    VEVEVE+L   E+A  AG DIIMLDN   EQ+ +A+ L  G++++E SGN
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  276  VTFETIREFAETGVDFISVGALTKHVRALDLSMR  309
            +   TI  F   ++D++S G+LT   ++LD+SM+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

656) Dfer_3879 in NC_013037


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (496),  Expect = 3e-33, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 175/272 (65%), Gaps = 13/272 (4%)

Query  18   EDIGDGDHSSLASVPENATKRAKLLVKQGGVLAGVEVAQIIFD--ETAKYYNHPLPKIDV  75
            ED+   D S+ A   +++  +  L+ K++GVLAG+ V Q +F   ++   +++P      
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQ----  78

Query  76   LLF-DGAVVSTGDIVFTVEGSARLILKAERLVLNIMQRMSGIATYARQMSDLIKDLPVKL  134
              F DG  +++GD+V+ + GS R +L  ER+ LN++Q++SGIA+ +    + + D  +K+
Sbjct  79   --FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  135  LDTRKTTPNFRLFEKLAVKIGGAVNHRMGLYDMIMLKDNHVDYAGGIEAAITGANKYLKE  194
            +DTRKTTPN+RLFEK AV++GG+ NHR  L D IMLKDNH+   G+++ AI+ A  Y   
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY--A  194

Query  195  TGRKLKIEVETRNLAEVDEVLRVGQVDIIMLDNFNLDDLREAVKRIGGRYETEASGNITE  254
               K+ +EVE  +LA  +E    G VDIIMLDN +L+++ +A+  I+GR   E SGNI  
Sbjct  195  PFVKM-VEVEVESLAAAEEAAAAG-VDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  255  KTLRAVAETGVDGISSGALTHQARSLDLSLKA  286
             T+      ++D +SSG+LTH A+SLD+S+K+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

657) A3UG_03760 in NC_018079


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (496),  Expect = 3e-33, Method: Compositional matrix adjust.
 Identities = 112/274 (41%), Positives = 174/274 (64%), Gaps = 2/274 (0%)

Query  24   PASVAHALKEDLGGDVSADNDITAQLLPKETRSHAVIITREDGVFCGKRWVEEVFTQLAG  83
            P  + ++LK  L  DV +++  T  ++  + ++   ++++E GV+ G    + VFT + +
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  84   D-DVQITWHVEDGDAITANQPLFELEGPSRVLLTGERTALNFVQTLSGVASEVRRYVNLL  142
            +   Q   +  DGD +T+ + ++E+ G+ R LLT ER ALNF+Q LSG+AS    YV+ L
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  143  AGTRTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEK  202
            ++ R +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GSV++A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  203  A-FWLHpdvpvevevenldeleQAIKAGADIIMLDNFETAQMREAVKLTNGQAQLEVSGN  261
            A         VEVEVE+L   E+A  AG DIIMLDN    Q+ +A+ L  G++++E SGN
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  262  VTFETIREFAETGVDYISVGALTKHVHALDLSMR  295
            +   TI  F   ++DY+S G+LT    +LD+SM+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

658) nadC in NC_020211


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (496),  Expect = 3e-33, Method: Compositional matrix adjust.
 Identities = 112/275 (41%), Positives = 178/275 (65%), Gaps = 5/275 (1%)

Query  24   PYAVAQALREDLGGEVDAGRDITAQLLPADKQAEATVITREAGVFCGRRWLNEVFIQLGN  83
            P+ + ++L+  L  +V++    T  ++  + QA  +++++EAGV+ G   ++ VF  ++ 
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  84   QV--QVEWLVADGDRLTPNQPLCRLRGPARVMLTGERTALNFVQTLSGVATEVSRYVALL  141
            +V  Q      DGDRLT+ + +  + G+ R +LT ER ALNF+Q LSG+A+  + YV  L
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  142  EGtrtrlldtrktlPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIKNAV--  199
             + R +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+  
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  200  EKAFWLHADVPVEVEVESLDELQQALDAGADIIMLDNFSVEMMRQAVAQTQGRAQLEVSG  259
             +A+     + VEVEVESL   ++A  AG DIIMLDN S+E + QA++   GR+++E SG
Sbjct  190  ARAYAPFVKM-VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  260  NVTRETLRTFAETGVDYISVGALTKHVTALDLSMR  294
            N+   T+  F   ++DY+S G+LT    +LD+SM+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

659) GEM_0925 in NC_018513


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (494),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 99/230 (44%), Positives = 159/230 (70%), Gaps = 3/230 (1%)

Query  64   LCGVPWFEAVIARIDPSIVVQ--WRYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQ  121
            L G+  F+ V++ +D+ +  Q   ++++GDR+T++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  122  LLSGVASATRRYVDRVEGTRARILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILIK  181
             LSG+AS T  YV+ + + R +++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  182  ENHIAAAGGVGEALDAAFALDSGVP-VQVEVETLAQLDTALAHGAQSVLLDNFTLDMMre  240
            +NHIAA G+V  A+  A A  + V  V+VEVE+LA  + A A G + ++LDN +L+ + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  241  avrvaagravlevSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMR  290
            A+ + AGR+ +E SG ++  T+  F   ++D +S G+LT   ++ D+SM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

660) HydHO_1045 in NC_020411


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (494),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 117/278 (43%), Positives = 186/278 (67%), Gaps = 8/278 (2%)

Query  1    MNWLKIDEALKSFLEEDIGWEDITSSGLPDNL-NAKGFIKVKESGVVSGLFFAKRVFELL  59
            +  ++ID++LK+ L ED+  ED +++++ D+  +AK  +  KE+GV++GL   +RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   GVKDITLKA----KDGDLVNKKDIIMELQGNAKALLMGERVALNLIQSLSGIATETKFML  115
            +  ++T++     KDGD +   D+++E+ G+ ++LL  ERVALN++Q LSGIA+ T   +
Sbjct  68   DA-EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  116  DKIKDYEVKLLDTRKTTPGYRFFEKYAVRTGAGTNHRFALYDMVLIKDNHINLYGSISKA  175
            + + D  +K++DTRKTTP  R+FEKYAVR G+G NHRF L D +++KDNHI   GS+ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  176  VQQIRKNLSMAYKVEVEVSNFEQLEEAlnldidmilldnFGVEDAKKVIELIRKRSSIKI  235
            + Q R   +    VEVEV ++   EEA   ++D+I+LDN ++E+  + I LI  RS  +I
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS--RI  244

Query  236  ELSGEINKDNIDEYAKTRPDYISSGAIIHSSKWLNASM  273
            E SG+I+   I  +     DY+SSG++ HS+K L+ SM
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

661) HydSN_1072 in NC_020814


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (494),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 117/278 (43%), Positives = 186/278 (67%), Gaps = 8/278 (2%)

Query  1    MNWLKIDEALKSFLEEDIGWEDITSSGLPDNL-NAKGFIKVKESGVVSGLFFAKRVFELL  59
            +  ++ID++LK+ L ED+  ED +++++ D+  +AK  +  KE+GV++GL   +RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   GVKDITLKA----KDGDLVNKKDIIMELQGNAKALLMGERVALNLIQSLSGIATETKFML  115
            +  ++T++     KDGD +   D+++E+ G+ ++LL  ERVALN++Q LSGIA+ T   +
Sbjct  68   DA-EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYV  126

Query  116  DKIKDYEVKLLDTRKTTPGYRFFEKYAVRTGAGTNHRFALYDMVLIKDNHINLYGSISKA  175
            + + D  +K++DTRKTTP  R+FEKYAVR G+G NHRF L D +++KDNHI   GS+ KA
Sbjct  127  EALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  176  VQQIRKNLSMAYKVEVEVSNFEQLEEAlnldidmilldnFGVEDAKKVIELIRKRSSIKI  235
            + Q R   +    VEVEV ++   EEA   ++D+I+LDN ++E+  + I LI  RS  +I
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS--RI  244

Query  236  ELSGEINKDNIDEYAKTRPDYISSGAIIHSSKWLNASM  273
            E SG+I+   I  +     DY+SSG++ HS+K L+ SM
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

662) BC1002_2394 in NC_014117


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (494),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 99/241 (42%), Positives = 163/241 (68%), Gaps = 3/241 (1%)

Query  68   NARIIVREEAVLCGVPWFDAVMRAVDPRIEVR--WRYGEGDRMSADTTVCDLRGPVRALL  125
            +  ++ +E +VL G+  F+ V    D+ +  +   ++ +GDR++++  V ++ G+VR+LL
Sbjct  43   KVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL  102

Query  126  TAERNAMNFLQLLSGVASATRRYVDAIAHTRTRVLDTRKTLPGLRLAQKYAVRVGGGANQ  185
            T ER A+NFLQ LSG+AS T  YV+A+++ R +V+DTRKT P LRL +KYAVRVGGG N+
Sbjct  103  TCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNH  162

Query  186  RLALYDGILIKENHIaaaggvgaamdaalalnagVP-IQIEVETLEQLEIALAHRAQSIL  244
            R+ L D+I++K+NHIAA G+V  A+  A A  + V  +++EVE+L   E A A   + I+
Sbjct  163  RFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIM  222

Query  245  LDNFSFDMMRDAVRTTAGRAVLEVSGGVNLETVRTIAETGVDRVSIGALTKDVRATDYSM  304
            LDN S++ + +A+   AGR+ +E SG +++ T+  +   ++D VS G+LT   ++ D+SM
Sbjct  223  LDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

Query  305  R  305
            +
Sbjct  283  K  283

663) nadC in NC_014012


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (494),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 102/248 (42%), Positives = 172/248 (70%), Gaps = 8/248 (3%)

Query  58   HAQASLITREEGVFCGKAWAEQVFNQLGGEVAIH--WHVDDGDLLVANQVLCELSGPARA  115
            +A+ SL+++E GV+ G +  ++VF  +++EV+++   +  DGD L + +++ E+ G+ R+
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  116  ILTGERTAMNFIQTLSGVATLTKHYVDKIAGTNTKLLDTRKTIPGLRTAQKYAVTCGGGK  175
            +LT ER A+NF+Q LSG+A++T  YV+ +++   K++DTRKT P LR  +KYAV  GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  176  NHRIGLYDAFLIKENHIMACGGIAQAISKARELHG-DKLveveveNILELQQALEAGSDI  234
            NHR+ L DA+++K+NHI A G++ +AI++AR      K+VEVEVE++   ++A  AG DI
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  235  IMLDNFDVTMMIEAVELNKRLADDKQAKLEVSGNVTIDTIADFAKTGVDYISVGALTKHV  294
            IMLDN    M +E +E    L  ++ +++E SGN+ + TI+ F   ++DY+S G+LT   
Sbjct  221  IMLDN----MSLEQIEQAITLIAGR-SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSA  275

Query  295  QALDLSLR  302
            ++LD+S++
Sbjct  276  KSLDFSMK  283

664) Swoo_0315 in NC_010506


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  135 bits (494),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 105/252 (42%), Positives = 173/252 (69%), Gaps = 10/252 (3%)

Query  47   DRHAQA--SLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLLVPNQVLCEFSG  102
            D+H+QA  SL+++E GV+ G +  ++VF  +++EV+++   +  DGD L + +++ E+ G
Sbjct  37   DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIG  96

Query  103  PARAILTGERTAMNFIQTLSGVATLTKQYTDRIATTNTRLLDTRKTIPGLRTAQKYAVTC  162
            + R++LT ER A+NF+Q LSG+A++T  Y + ++    +++DTRKT P LR  +KYAV  
Sbjct  97   SVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRV  156

Query  163  GGGKNHRIGLFDAFLIKENHIMACGGIAQAISKARELQP-DKLveveveSILELQQALEA  221
            GGG NHR+ L DA+++K+NHI A G++ +AI++AR   P  K+VEVEVES+   ++A  A
Sbjct  157  GGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAA  216

Query  222  GSDIIMLDNFDVTMMIAAVELNKRLPDAQQAKLEVSGNVTLETIGDFAKTGVDYISVGAL  281
            G DIIMLDN  +  +  A+ L      A ++++E SGN+ + TI+ F   ++DY+S G+L
Sbjct  217  GVDIIMLDNMSLEQIEQAITLI-----AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSL  271

Query  282  TKHVKALDLSLR  293
            T   K+LD+S++
Sbjct  272  THSAKSLDFSMK  283

665) Fphi_1848 in NC_010336


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (493),  Expect = 4e-33, Method: Compositional matrix adjust.
 Identities = 85/205 (42%), Positives = 145/205 (71%), Gaps = 1/205 (0%)

Query  81   YDDADKISAGEKIFELRGNARSILTAERAMLNFIQMLSATATATNNLVKLIADYKTKLLD  140
            + D+D++++G+ ++E+ G+ RS+LT ER  LNF+Q LS+ A+ T   V  ++D + K++D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  141  TRKTIPCFRMAQKYAVRCGGGFNHRIGLFDAYLIKENHIRSAGGIAKAVSKAARLQP-TK  199
            TRKT P +R+ +KYAVR GGG+NHR+ L DA ++K+NHI + G++ KA+++A    P  K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  200  TIEVEVTNLDELNQAIQAGANIIMLDNFSIEDINKAVEIAKDKVALEVSGNIDSNSIVKM  259
             +EVEV +L   ++A  AG +IIMLDN S+E+I++A+ +  ++  +E SGNID  +I + 
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  260  AQTGVDFISVGAITKHITAIDLSMQ  284
               ++D++S G++T    ++D+SM+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

666) Varpa_4765 in NC_014931


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (493),  Expect = 5e-33, Method: Compositional matrix adjust.
 Identities = 92/208 (45%), Positives = 140/208 (68%), Gaps = 5/208 (2%)

Query  81   EGERCAADQTVLEIEGTARALLTAERTSLNFLQLLSAVATKTALYADAVEGTRARIVDTR  140
            +G+R ++++ VLEI G+ R+LLT ER +LNFLQ LS++A+ TA Y +A+ + R ++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  141  KTLPGLRLAQKYAVRTGGGLNHRIGLYDAVLIKENHIVAAGGVAAALRSVAPGASQADFV  200
            KT P LRL +KYAVR GGG NHR+ L DA+++K+NHI A G+V  A+    + A+    V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  201  EVEVETLAQLREALGAGARMVLLDNMDLPTLREAVRINDEAGADRKAVLEISGGVTLEGL  260
            EVEVE+LA   EA +AG  +++LDNM L  + +A+ +   AG  R   +E SG + +  +
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI--AGRSR---IECSGNIDMTTI  255

Query  261  RALAETGVDRISVGALTKDVKAIDFSMR  288
              +   ++D +S G+LT   K++DFSM+
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

667) BC1001_2798 in NC_015136


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (493),  Expect = 5e-33, Method: Compositional matrix adjust.
 Identities = 98/238 (42%), Positives = 164/238 (69%), Gaps = 3/238 (1%)

Query  73   VIVREDAVLCGVPWFNAVLRQVDSRIEVH--WHYREGDRMTADTPVCELRGPVRALLTAE  130
            ++ +E +VL G+  F+ V+   D+ +  +   ++++GDR+T++  V E+ G+VR+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  131  RNALNFLQLLSGVASTTRRYVDAIAHTHTRILDTRKTLPGLRLAQKYAVRVGGGANQRLA  190
            R ALNFLQ LSG+AS T  YV+A+++ + +++DTRKT P LRL +KYAVRVGGG N+R+ 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  191  LYDGILIKENHIaaaggvgaamdaalalnagVS-IQIEVETLEQLQTALAHRAQSILLDN  249
            L D+I++K+NHIAA G+V  A+  A A  + V  +++EVE+L   + A A   + I+LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  250  FSFHAMREAVRITAGRAVLEVSGGVNFETVRTIAETGVDRVSIGALTKDVRATDYSLR  307
             S++ + +A+ + AGR+ +E SG ++  T+  +   ++D VS G+LT   ++ D+S++
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

668) Psefu_0599 in NC_015556


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (493),  Expect = 5e-33, Method: Compositional matrix adjust.
 Identities = 110/272 (41%), Positives = 194/272 (72%), Gaps = 4/272 (1%)

Query  12   EIEANVRRSLREDIGSGDITAQLIPESR-LANATVITRDHAVICGTAWVDEVFHQLDARV  70
            +I+  ++ +LRED+ S D +++ I + +  A+ ++++++ +V+ G +  + VF  +DA V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  71   AVH--WQVQDGQQVTPNQALFHLEGPARALLSGERTALNFLQTLSAVATRCQHYANLVQG  128
            + +   Q +DG+++T+ + ++++ G+ R+LL+ ER ALNFLQ LS++A+    Y + + +
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  129  TGVKLLDTRKTLPGLRLAQKYAVTQGGCHNHRIGLFDAFLIKENHiaacggiaaavtaar  188
              +K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++  A++ AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  189  giaP-GKPvevevesleelQQALTAGADIIMLDELSLDDMRQAVAITAGRAKLEASGGIN  247
            + AP  K VEVEVESL   ++A +AG DIIMLD++SL+++ QA+++ AGR+++E SG I+
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  248  DSTLRGIAETGVDYISIGTLTKDVKAVDLSMR  279
             +T+  +   ++DY+S G+LT   K++D+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

669) Tint_0897 in NC_014153


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (493),  Expect = 5e-33, Method: Compositional matrix adjust.
 Identities = 107/267 (41%), Positives = 179/267 (68%), Gaps = 3/267 (1%)

Query  12   VRRALEEDLGSGDL-TAALIDPQAVARATVRSREAARLCGTPWANACVRALDPAAHLEWL  70
            ++ AL ED+ S D  T A++D ++ A+ ++ ++EA+ L G    +     +D+   ++  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  71   AP--EGATLQADAVFLEIRGNARALLSAERTMLNFLQLLSAVATRTAQYVDVVRGTRAQI  128
                +G  L ++ + LEI G+ R+LL+ ER  LNFLQ LS++A+ TA YV+ + + R ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  129  VDTRKTLPGLRLAQKYAVRVGGGMNHRIGLFDAVLIKENHIaaaggvalalqraqavaaq  188
             DTRKT P LRL +KYAVRVGGG NHR+ L DA+++K+NHIAA G+V  A+ +A+A A+ 
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  189  aqFIQIEVETLAQLDEALRAGARMVLLDNMSLDQLREAVHLTGQRAVLEVSGGVDLQTVR  248
             + +++EVE+LA  +EA  AG  +++LDNMSL+Q+ +A+ L + R+ +E SG +D+ T+ 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  249  AIAETGVDRISVGKLTKDVQAVDLSMR  275
             +   ++D +S G LT   +++D+SM+
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

670) Ava_3136 in NC_007413


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (492),  Expect = 6e-33, Method: Compositional matrix adjust.
 Identities = 118/270 (44%), Positives = 175/270 (65%), Gaps = 6/270 (2%)

Query  18   RGWLLEDVGRGDRTTNGLLAADVTLGSAKWIAKAPGVIAGLPVAARVFQLLNEKVSFVTT  77
            ++ L EDV   D +TN+++  +   +    +AK +GV+AGL V  RVF L++  V+F   
Sbjct  18   KAALREDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  78   --IDEGAFCKPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATLTNTYVEKIADLPARL  135
              + +G    +G++V EI GS+ +LL  ERVALN+   LSGIA++T +YVE ++D   ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  136  VDTRKTTPGLRLLEKYATAVGGATNHRMGLDDAVMIKDNHiaaaggigeaitriraQIPY  195
             DTRKTTP LRL+EKYA  VGG+ NHR  L DA+M+KDNHIAA G++  AI++ RA  P+
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  196  tltievetetieQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQDNGVKIEASGNVTLE  255
               +EVE E++    EA     DIIMLDNM+++ + QA+ LI  +    +IE SGN+ + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGNIDMT  253

Query  256  TIRAVAETGVDYISSSAPITQSKWLDLSMK  285
            TI      ++DY+SS++    +K LD+SMK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

671) nadC in NC_009464


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (491),  Expect = 6e-33, Method: Compositional matrix adjust.
 Identities = 104/244 (43%), Positives = 160/244 (66%), Gaps = 10/244 (4%)

Query  29   ASANIVCKEDGVLAGLDEALQVFEYFG--LSLES--HYADGNPIKAGDVIMTITGDAADI  84
            A  ++  KE GVLAGL    +VF  F+  +++++  ++ DG+ + +GD+++ I G    +
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  85   LRGERLALNFLGRMSGIATLTRRCVSRAGNARIAA--TRKTTPGFRSFEKKAVKLGGGDT  142
            L  ER+ALNFL ++SGIA++T   V   G+ RI    TRKTTP +R FEK AV++GGG  
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  143  HRYDLSAAVMIKDNHiaimgiegaiaaakka-aSFTKKIEIEVESVEDGEKAASLGADII  201
            HR++LS A+M+KDNHIA +G      A  +A A+F K +E+EVES+  +E AA+ G DII
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  202  MFDNMAPDRIAEGVARVKKINPRVIVEASGGITMNNIGDYARAGVDVISLGALTRDAKWL  261
            M+DNM+ ++I ++++    I  R  +E SG I M  I+ +   ++D +S G+LT+ AK L
Sbjct  222  MLDNMSLEQIEQAIT---LIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  262  DFSL  265
            DFS+
Sbjct  279  DFSM  282

672) Glo7428_4347 in NC_019745


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (491),  Expect = 7e-33, Method: Compositional matrix adjust.
 Identities = 118/270 (44%), Positives = 178/270 (66%), Gaps = 6/270 (2%)

Query  18   RAWLIEDIGRGDRTTQGLLSAENPWVSAQWIAKAPGVIAGLPVAARVFQLLSEQTRFITT  77
            +A L ED+   D +T++++  +        +AK +GV+AGL V  RVF L+  +  F   
Sbjct  18   KAALREDVHSEDYSTNAIFDHHGQ-AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  78   --VDEGQLCQPGQVVAQIEGPLEALLTGERVALNLVMRLSGIASLTRKYVEKLAELPTRL  135
                +G+   +G++V +I G++ +LLT ERVALN++ +LSGIAS+T  YVE L++   ++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  136  VDTRKTTPGLRLLEKYATQVGGAKNHRMGLDDAVMIKDNHiaaaggignaiariraQISY  195
             DTRKTTP LRL+EKYA +VGG+ NHR  L DA+M+KDNHIAA G++ +AIA+ RA  ++
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  196  PLtievetetieqvqeALQHQADIIMLDNMPVEVMYQAVNLIRQYNKRIKIEASGNITLD  255
               +EVE E++   +EA     DIIMLDNM++E + QA+ LI     R +IE SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMT  253

Query  256  TIYQVAATGVDYVSTSAPVTQSSWLDLSMK  285
            TI +  + ++DYVS+++    +  LD+SMK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

673) Shew_3435 in NC_009092


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (491),  Expect = 7e-33, Method: Compositional matrix adjust.
 Identities = 106/247 (43%), Positives = 169/247 (69%), Gaps = 8/247 (3%)

Query  47   AQASLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLVLPNQVLCEMSGSARAI  104
            A+ SL+++E GV+ G +  ++VF  +++EV+++   +  DGD + + +++ E+ GS R++
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  105  LTGERTAMNFIQTLSGVATLTKLYVDRLAGTHCKLLDTRKTIPGLRTAQKYAVTCGGGKN  164
            LT ER A+NF+Q LSG+A++T  YV+ L++ + K++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  165  HRIGLFDAFLIKENHimasgsiasainaaRQLAS-DKLVEVEVESIDELKQALDAGADIV  223
            HR+ L DA+++K+NHI A GS+  AI  AR  A+  K+VEVEVES+    +A  AG DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  224  MLDNFDVTMMIEAVELNNSYNENQRVKLEVSGNVTLDTISDYAKTGIDYISVGALTKHVK  283
            MLDN  +  + +A+ L  +     R ++E SGN+ + TIS +   +IDY+S G+LT   K
Sbjct  222  MLDNMSLEQIEQAITLIAG-----RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK  276

Query  284  ALDLSLR  290
            +LD+S++
Sbjct  277  SLDFSMK  283

674) BC1003_2736 in NC_014539


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (491),  Expect = 7e-33, Method: Compositional matrix adjust.
 Identities = 97/238 (41%), Positives = 163/238 (69%), Gaps = 3/238 (1%)

Query  73   VIVREDAVLCGVPWFNAVLREVDPRIEVQWC--YREGDRMSADTPVCELRGPVRALLTAE  130
            ++ +E +VL G+  F+ V+   D+ +  Q    +++GDR++++  V E+ G+VR+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  131  RNALNFLQLLSGVATATRRYVDAISHTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLA  190
            R ALNFLQ LSG+A+ T  YV+A+++ R +++DTRKT P LRL +KYAVRVGGG N+R+ 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  191  LYDGILIKENHIaaaggvgaamdaalalnagVP-IQIEVETLEQLETALAHRAQSVLLDN  249
            L D+I++K+NHIAA G+V  A+  A A  + V  +++EVE+L   E A A   + ++LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  250  FTFDAMREAVRITAGRAVLEVSGGVNFDTVKTIAETGVDRVSIGALTKDVRATDYSLR  307
             +++ + +A+ + AGR+ +E SG ++  T+  +   ++D VS G+LT   ++ D+S++
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

675) Ppha_2566 in NC_011060


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  134 bits (491),  Expect = 7e-33, Method: Compositional matrix adjust.
 Identities = 110/269 (41%), Positives = 167/269 (63%), Gaps = 8/269 (2%)

Query  28   ALEEDRYKGDVTTLATIDPSQGGSAVIRAKEDGILGGADVAVQVFAACDNKLSVVLHHH-  86
            AL ED    D +T A +D    +   + AKE G+L+G  V  +VF+  D  ++    H+ 
Sbjct  20   ALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF  79

Query  87   -DGETLQRGDLILEVQGKLAPLLIGERTALNFMQRMSGIATRTRLYVDCIRHTGAEILDT  145
             DG+ L  GDL+LE+ G + +LL  ER ALNF+Q++SGIA+ T  YV+ + +    ++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  146  RKTAPGLRYFDKEAVRIGGGKNHRFGLFDMILIKDNHIDASGGIANAIRRAQLYRKEGKL  205
            RKT+P LR F+K AVR+GGG NHRF L D I++KDNHI A G++ +AI +A+ Y    K+
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  206  EVKIETEVRSMEELREALPCLPDIILLDNFTPELLKEAVLFVKSSGFTPLLEASGNITLH  265
               +E EV S+    EA +   DII+LDN + E + +A+ ++ +    + +E SGNI + 
Sbjct  200  ---VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR---SRIECSGNIDMT  253

Query  266  NVLEVAETGVDFISVGELTHSVKALDLSM  294
             +      ++D++S G LTHS K+LD+SM
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

676) nadC in NC_000917


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  133 bits (487),  Expect = 1e-32, Method: Compositional matrix adjust.
 Identities = 105/247 (43%), Positives = 163/247 (66%), Gaps = 14/247 (5%)

Query  18   IVSKGEGVLAGVGVVKILFDL--AEIVVMESK--KDGEPIKPGDVVMRLRGKSDSILATE  73
            + +K  GVLAG+ V + +F L  AE+   ++   KDG+ + +GD+V+ + G   S+L+ E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  74   RLAINILMRMSGIATATAKMVERARRVNPKVVVAATRKTTPGFRIFEKMAVEIGGGDAHR  133
            R+A+N+L ++SGIA+ TA  VE     + ++ V  TRKTTP +R+FEK AV +GGG  HR
Sbjct  106  RVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  134  FSLSDCLMLKDNHIAVAGSLERAMKVKRSFT---KKLEVEVGSVGDAIKAAEFGADIIML  190
            F+LSD +MLKDNHIA  GS+++A+   R+++   K +EVEV S++ A  AA  G DIIML
Sbjct  164  FNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIML  223

Query  191  DNFTPEMVAEAVEELRRRGLREKVIIEVSGSVTPENVAEFAAMDVDVISSGYITHSAPAL  250
            DN + E + +A+  +  R+      IE SG++    ++ F ++ +D +SSG +THSA +L
Sbjct  224  DNMSLEQIEQAITLIAGRS-----RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  251  DFSLRVL  257
            DFS++ L
Sbjct  279  DFSMKGL  285

677) Metme_4340 in NC_015572


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  133 bits (487),  Expect = 1e-32, Method: Compositional matrix adjust.
 Identities = 109/263 (42%), Positives = 181/263 (69%), Gaps = 5/263 (1%)

Query  14   LAEDVGDGDLTAN-IIPETVQASARVVTRENMLLCGQAWFDAVFRHLNQHVVIEWA--YQ  70
            L EDV   D ++N I+ +  QA   + ++E  +L G + F+ VF  ++ +V ++ +  ++
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  71   EGDEIAAGSVLCQLHGPARTLLTGERTALNLLQTLSATATVARRYAQAVAGTHCKVLDTR  130
            +GD +++G ++ ++ G+ R+LLT ER ALN+LQ LS+ A+++  Y +A+++ + KV+DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  131  KTIPGLRLAQKYAVRCGGCVNHRIGLFDAILIKENHiiaagsisaaiakaRELSDV--LV  188
            KT P LRL +KYAVR GG  NHR+ L DAI++K+NHI A GS+  AIA+AR  +    +V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  189  EIEVESlaelqealaaqPDRIMLDNFTTDDLRRAVALNHGKVELEASGNVSLDTIRGIAE  248
            E+EVESLA  +EA AA  D IMLDN + +++ +A++L  G+  +E SGN+ + TI  +  
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  249  TGVDYISIGALTKNLNAIDLSMR  271
             ++DY+S G+LT + +++D+SM+
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSMK  283

678) Rpic_2716 in NC_010682


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  133 bits (489),  Expect = 1e-32, Method: Compositional matrix adjust.
 Identities = 101/242 (42%), Positives = 161/242 (67%), Gaps = 3/242 (1%)

Query  58   ARARVIVREHAVLCGTPWFDACMRAVDPTLRVTWRQH--EGDRMAPDSVVCEIEGPARSL  115
            A+  ++ +E +VL G   F+      D+ +     ++  +GDR++++ +V EI G+ RSL
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  116  LTAERPSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGLRLAQKYAVRIGGGEN  175
            LT ER +LNFLQ LSG+A+ T+ Y  A+ + R +V+DTRKT P LRL +KYAVR+GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  176  QRLALYDGILIKENHIaaaggvtaalraaqalnagVT-IQVEVETLAQLDEALAAGATSV  234
            +R+ L D+I++K+NHIAA G+V  A+  A+A  + V  ++VEVE+LA  +EA AAG   +
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  235  LLDNFEPPAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVRATDFS  294
            +LDN     + +A+ + AGR+ +E SG +++ TI  F   ++D +S G+LT   ++ DFS
Sbjct  222  MLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

Query  295  LR  296
            ++
Sbjct  282  MK  283

679) CL1_0797 in NC_018015


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  133 bits (488),  Expect = 1e-32, Method: Compositional matrix adjust.
 Identities = 108/267 (41%), Positives = 173/267 (65%), Gaps = 15/267 (5%)

Query  13   EDAPFGDVTSEAVIPEGTRAKAVIIAKGEGVIAGVEEARALFGHFGVKVEVRK----MDG  68
            ED    D +++A++ +  +AK  ++AK  GV+AG+   + +F  F+  V  ++     DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  69   EEVKRGDVILELEGDARAILLVERTALNVMGRMSGIATEVRKLVERVKAVNPKVRVAGTR  128
            + +  GD++LE+ G  R++L  ER ALN + ++SGIA+     VE +   + +++V +TR
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG--DDRIKVFDTR  140

Query  129  KTL--LKPIDKRAILIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIKRARAFSAY-KVV  184
            KT   L+ ++K A+ +GGG  HRF+LSDAI++KDNH+A V +++ AI +ARA++++ K+V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  185  EVEVESLEDALKAARAGADVVMLDNMSPAEIAEVLTVLKREGLRERVKIEVSGGITPENI  244
            EVEVESL  A  AA AG D++MLDNMS  +I + +T++       R +IE SG I    I
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA-----GRSRIECSGNIDMTTI  255

Query  245  AEYAGLDIDVISLGYLTHSVKNFDVSL  271
            + + GL ID +S G LTHS K++D S+
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

680) nadC in NC_008570


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  132 bits (484),  Expect = 2e-32, Method: Compositional matrix adjust.
 Identities = 105/242 (44%), Positives = 166/242 (69%), Gaps = 3/242 (1%)

Query  45   ASARVITREAGVFCGQPWVDEVFVQLGGEVRVE--WLVQDGEVLSPNQELFRLHGPARVL  102
            A   ++++EAGV+ G    + VF  +++EV  +     +DG+ L++ + ++ + G+ R L
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  103  LTGERNALNFVQTLSGVASLTARYVAELADTDCRLLDTRKTLPGLRSAQKYAVTCGGGKN  162
            LT ER ALNF+Q LSG+AS+TA YV  L+D   +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  163  HRIGLFDAYLIKENHILACGGIAEAISEARRLNP-GKPveveveslveleqalaaGADIV  221
            HR+ L DA ++K+NHI A G++  AI++AR   P  K VEVEVESL   E+A AAG DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  222  MLDNFDIPMMREAVALNQSRAKLEVSGNVTLDTLADYAATGVDFISVGALTKHVRALDLS  281
            MLDN  +  + +A++L  +R+++E SGN+ + T++ + + ++D++S G+LT   ++LD+S
Sbjct  222  MLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

Query  282  MR  283
            M+
Sbjct  282  MK  283

681) Rpic12D_2326 in NC_012856


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  132 bits (484),  Expect = 2e-32, Method: Compositional matrix adjust.
 Identities = 102/247 (42%), Positives = 165/247 (67%), Gaps = 5/247 (2%)

Query  55   DRHARARV--IVREHAVLCGTPWFDACMRAVDSALRVTWRQH--EGDCMSPDSVVCEIEG  110
            D+H++A+V  + +E +VL G   F+      D+ +     ++  +GD ++++ +V EI G
Sbjct  37   DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIG  96

Query  111  PARSLLTAERPSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGLRLAQKYAVRI  170
            + RSLLT ER +LNFLQ LSG+A+ T+ Y  A+ + R +V+DTRKT P LRL +KYAVR+
Sbjct  97   SVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRV  156

Query  171  GGGENQRLALYDGILIKENHIaaaggvtaalraaqalnagVT-IQIEVETLAQLDEALAA  229
            GGG N+R+ L D+I++K+NHIAA G+V  A+  A+A  + V  +++EVE+LA  +EA AA
Sbjct  157  GGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAA  216

Query  230  GATSVLLDNFEPPAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVR  289
            G   ++LDN     + +A+ + AGR+ +E SG +++ TI  F   ++D +S G+LT   +
Sbjct  217  GVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK  276

Query  290  ATDFSLR  296
            + DFS++
Sbjct  277  SLDFSMK  283

682) Hydth_0638 in NC_017161


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  132 bits (484),  Expect = 2e-32, Method: Compositional matrix adjust.
 Identities = 111/273 (41%), Positives = 180/273 (66%), Gaps = 4/273 (1%)

Query  1    MEEAIREFLREDIGHGDITTEGIF-RGERVKAVLIAKEGGCLAGMPFATKVFEILGGVQT  59
            ++++++  LRED+   D +T++IF +  + K  L+AKE+G LAG+    +VF ++++  T
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  60   FSTK---KDGETFEAGERLLILEGSAESILKGERLALNILQSLSGIATLTRTVVEKLKGT  116
            F      KDG+ + +G+ +L + GS  S+L  ER+ALN+LQ LSGIA++T + VE L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  117  GIELLDTRKTTPGFRYFEKYAVRVGGGKNHRFGLYDMVLIKDNHKRVAGGIKEAVKRVKQ  176
             I ++DTRKTTP +R FEKYAVRVGGG NHRF L D +++KDNH    G+++ A+ + + 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  177  VLGPAYKIevevesieelyealecevDMVMLDNFTPDDVKRAveiikgkvkvevSGNITP  236
                   +EVEVES+    EA    VD++MLDN + +++ +A+ +I G+ ++E SGNI  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  237  ENIKEYAIEGVNYISCGFITHSARWIDMSLRVL  269
              I  +   +++Y+S G +THSA+ +D S++ L
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

683) nadC in NC_013799


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  132 bits (484),  Expect = 2e-32, Method: Compositional matrix adjust.
 Identities = 111/273 (41%), Positives = 180/273 (66%), Gaps = 4/273 (1%)

Query  1    MEEAIREFLREDIGHGDITTEGIF-RGERVKAVLIAKEGGCLAGMPFATKVFEILGGVQT  59
            ++++++  LRED+   D +T++IF +  + K  L+AKE+G LAG+    +VF ++++  T
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  60   FSTK---KDGETFEAGERLLILEGSAESILKGERLALNILQSLSGIATLTRTVVEKLKGT  116
            F      KDG+ + +G+ +L + GS  S+L  ER+ALN+LQ LSGIA++T + VE L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  117  GIELLDTRKTTPGFRYFEKYAVRVGGGKNHRFGLYDMVLIKDNHKRVAGGIKEAVKRVKQ  176
             I ++DTRKTTP +R FEKYAVRVGGG NHRF L D +++KDNH    G+++ A+ + + 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  177  VLGPAYKIevevesieelyealecevDMVMLDNFTPDDVKRAveiikgkvkvevSGNITP  236
                   +EVEVES+    EA    VD++MLDN + +++ +A+ +I G+ ++E SGNI  
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  237  ENIKEYAIEGVNYISCGFITHSARWIDMSLRVL  269
              I  +   +++Y+S G +THSA+ +D S++ L
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGL  285

684) MM_2070 in NC_003901


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  132 bits (484),  Expect = 2e-32, Method: Compositional matrix adjust.
 Identities = 100/244 (41%), Positives = 155/244 (64%), Gaps = 13/244 (5%)

Query  33   IFTKEDCTVAGIDEAVSIFYYFG----IQAETDFKDGDQLKKGDIIFRLKGGAVSILRAE  88
            +F+KE   +AG+     +F  F+    +Q   +FKDGD+L  GD+++ + G+  S+L  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  89   RISLNFLGHLSGIATLTRKCMDIARKHSETVRVACTRKTTPGIRKFEKLAVAAGGGDTHR  148
            R++LNFL HLSGIA++T   ++      + ++V  TRKTTP +R FEK AV  GGG  HR
Sbjct  106  RVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  149  FNLSDAVMIKDNHVKLMG-IEAAIKEARK-TSFTRKIEVEVESAEDAVFAAELGADIIML  206
            FNLSDA+M+KDNH+  +G ++ AI +AR  ++F + +EVEVES   A  AA  G DIIML
Sbjct  164  FNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIML  223

Query  207  DNMQPDGVKETISILNGKGLRESVLIEASGGISLENLEAYAKTGVDVISMGLLIHRSRWI  266
            DNM  + + ++I+++ G++ R    IE SG I +  +  +   ++D +S G L H ++ +
Sbjct  224  DNMSLEQIEQAITLIAGRS-R----IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  267  DVSL  270
            D S+
Sbjct  279  DFSM  282

685) MmTuc01_2137 in NC_020389


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  132 bits (484),  Expect = 2e-32, Method: Compositional matrix adjust.
 Identities = 100/244 (41%), Positives = 155/244 (64%), Gaps = 13/244 (5%)

Query  33   IFTKEDCTVAGIDEAVSIFYYFG----IQAETDFKDGDQLKKGDIIFRLKGGAVSILRAE  88
            +F+KE   +AG+     +F  F+    +Q   +FKDGD+L  GD+++ + G+  S+L  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  89   RISLNFLGHLSGIATLTRKCMDIARKHSETVRVACTRKTTPGIRKFEKLAVAAGGGDTHR  148
            R++LNFL HLSGIA++T   ++      + ++V  TRKTTP +R FEK AV  GGG  HR
Sbjct  106  RVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHR  163

Query  149  FNLSDAVMIKDNHVKLMG-IEAAIKEARK-TSFTRKIEVEVESAEDAVFAAELGADIIML  206
            FNLSDA+M+KDNH+  +G ++ AI +AR  ++F + +EVEVES   A  AA  G DIIML
Sbjct  164  FNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIML  223

Query  207  DNMQPDGVKETISILNGKGLRESVLIEASGGISLENLEAYAKTGVDVISMGLLIHRSRWI  266
            DNM  + + ++I+++ G++ R    IE SG I +  +  +   ++D +S G L H ++ +
Sbjct  224  DNMSLEQIEQAITLIAGRS-R----IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  267  DVSL  270
            D S+
Sbjct  279  DFSM  282

686) ABLL_2558 in NC_017192


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (482),  Expect = 3e-32, Method: Compositional matrix adjust.
 Identities = 97/239 (41%), Positives = 152/239 (64%), Gaps = 9/239 (3%)

Query  38   KSDGILAGVQ-YAKVLARTEKFDCKFLK----NDGDEIKVGDVIAELEGKASILLSSERT  92
            K  G+LAG+  + +V++  +  +  F +    +DGD +  GD++ E+ G    LL+ ER 
Sbjct  49   KEAGVLAGLTVFQRVFTLFDA-EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERV  107

Query  93   FLNMLQHASGIATMANKYAKLIEGTGVVLLDTRKTRPQLRDFEKYASRVGGAINHRLGLD  152
             LN LQH SGIA+M+  Y   + +  + ++DTRKT P+LR FEKYA RVGG+ NHR+ L 
Sbjct  108  ALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLS  167

Query  153  DCLMLKDTHLRTISNLEEFIKKARKRISWVTKIEIECETFDQVKEAMHAGGDIIMCDNMN  212
            D +MLKD H+ ++++++  I +AR   + V  +E+E E++    EA  AG DIIM DNM+
Sbjct  168  DAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMS  227

Query  213  IEQIKEVVEFRNANYPHILLEASGNINLRTIKEYATTGVDAISSGSIIHQSTWLDFSMK  271
            +EQI + + +  +  ++I  E SGNI++ TI  +   ++D +SSGS+ H +  LDFSMK
Sbjct  228  LEQIEQAITLIAGR-SRI--ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

687) AOLE_19175 in NC_014259


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (481),  Expect = 4e-32, Method: Compositional matrix adjust.
 Identities = 113/271 (42%), Positives = 180/271 (67%), Gaps = 4/271 (1%)

Query  12   IQINIQQALQEDIGDGDI-TAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQ  70
            I+  ++ AL+ED+   D  T  +  ++ QA  +++++E  VLAG    + +++ +D  V 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  71   VTWLKQ--EGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGl  128
                 Q  +GDR+++ +  L + GS RSLLT ER ALNF+Q LS++A+ TA YV+ L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  129  ktklldtrktlPGLRIAQKYAVAIGGGQNHRLGLFDAFLIKENHIMaaggiaqaiakaHE  188
            + K++DTRKT P LR+ +KYAV +GGG NHR+ L DA+++K+NHI A G++ +AIA+A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  189  IAP-GKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKYVAGRCKLEASGNITI  247
             AP  K VEVEVE+    ++A  AG DI+MLDN S +Q+ +A+  +AGR ++E SGNI +
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  248  ENLREVATTGVDYISMGVLTKDVRAVDLSMR  278
              +      ++DY+S G LT   +++D+SM+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

688) nadC in NC_018268


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (481),  Expect = 4e-32, Method: Compositional matrix adjust.
 Identities = 109/269 (41%), Positives = 181/269 (68%), Gaps = 4/269 (1%)

Query  13   ETVAHSLREDIGDGDITAQ-LIAADTRASGRVITREHAVIAGREWVDEVFRQVDCDIVLD  71
            +T+  +LRED+   D +++ ++  + +A   ++++E +V+AG    + VF   D ++ ++
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  72   --WQVADGQRVEPGQLLFRMNGLARSLLTAERAALNWLQTLSAVATNAAHYAALISHTRT  129
               Q  DG+R+ +G+L++ + G  RSLLT ER ALN LQ LS++A+ +A Y   +++ R 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  130  QLLDTRKTLPGLRLAQKYAITCGGCSNHRLGLWDAFLIKENHIaacgsiaaavraarela  189
            +++DTRKT P LRL +KYA+  GG  NHR+ L DA+++K+NHIAA GS+  A+  AR  A
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  190  P-GKPVEVETENLNELQQALDAGADIIMLDEFSLADMRaavaqaagkaRLEASGGIDDST  248
            P  K VEVE E+L   ++A  AG DIIMLD+ SL ++  A++  AG++R+E SG ID +T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  249  LVAIAETGVDFVSLGTLTKNLRAVDLSMR  277
            +  +   ++D+VS G+LT + +++D+SM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

689) nadC in NC_021150


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (480),  Expect = 5e-32, Method: Compositional matrix adjust.
 Identities = 113/282 (41%), Positives = 194/282 (69%), Gaps = 5/282 (1%)

Query  3    DLILADLSA-EIAANVRRALAEDIGGGDITAQLIPEGR-QARARVITREATVIAGSAWVD  60
             +I +DL++ +I   ++ AL ED+ + D +++ I + + QA+  ++++EA V+AG +  +
Sbjct  2    SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  61   EVFRQIDPRVAVR--WEVADGERVDADKLLFSLEGPARALLSGERSALNFLQTLSAVATR  118
             VF  +D+ V+ +   +  DG+R+ ++ L++ + G+ R+LL+ ER ALNFLQ LS++A+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  119  CRYYANLVEGTPVRLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLFDAFLIKENHiaacg  178
               Y + + +  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  179  giaaavatarriaP-GKPvevevedlqeldqALNAGADIVMLDELSLEDMHIAVRRTAGR  237
            ++  A+A AR  AP  K VEVEVE L   ++A  AG DI+MLD++SLE+++ A+   AGR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  238  AKLEASGGINESSLRRIAETGVDYISLGTLTKDIKAVDLSMR  279
            +++E SG I+ +++ R+   ++DY+S G+LT   K++D+SM+
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

690) nadC in NC_021149


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (480),  Expect = 5e-32, Method: Compositional matrix adjust.
 Identities = 113/282 (41%), Positives = 194/282 (69%), Gaps = 5/282 (1%)

Query  3    DLILADLSA-EIAANVRRALAEDIGGGDITAQLIPEGR-QARARVITREATVIAGSAWVD  60
             +I +DL++ +I   ++ AL ED+ + D +++ I + + QA+  ++++EA V+AG +  +
Sbjct  2    SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  61   EVFRQIDPRVAVR--WEVADGERVDADKLLFSLEGPARALLSGERSALNFLQTLSAVATR  118
             VF  +D+ V+ +   +  DG+R+ ++ L++ + G+ R+LL+ ER ALNFLQ LS++A+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  119  CRYYANLVEGTPVRLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLFDAFLIKENHiaacg  178
               Y + + +  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  179  giaaavatarriaP-GKPvevevedlqeldqALNAGADIVMLDELSLEDMHIAVRRTAGR  237
            ++  A+A AR  AP  K VEVEVE L   ++A  AG DI+MLD++SLE+++ A+   AGR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  238  AKLEASGGINESSLRRIAETGVDYISLGTLTKDIKAVDLSMR  279
            +++E SG I+ +++ R+   ++DY+S G+LT   K++D+SM+
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

691) nadC in NC_012560


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (480),  Expect = 5e-32, Method: Compositional matrix adjust.
 Identities = 113/282 (41%), Positives = 194/282 (69%), Gaps = 5/282 (1%)

Query  3    DLILADLSA-EIAANVRRALAEDIGGGDITAQLIPEGR-QARARVITREATVIAGSAWVD  60
             +I +DL++ +I   ++ AL ED+ + D +++ I + + QA+  ++++EA V+AG +  +
Sbjct  2    SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQ  61

Query  61   EVFRQIDPRVAVR--WEVADGERVDADKLLFSLEGPARALLSGERSALNFLQTLSAVATR  118
             VF  +D+ V+ +   +  DG+R+ ++ L++ + G+ R+LL+ ER ALNFLQ LS++A+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  119  CRYYANLVEGTPVRLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLFDAFLIKENHiaacg  178
               Y + + +  ++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  179  giaaavatarriaP-GKPvevevedlqeldqALNAGADIVMLDELSLEDMHIAVRRTAGR  237
            ++  A+A AR  AP  K VEVEVE L   ++A  AG DI+MLD++SLE+++ A+   AGR
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR  241

Query  238  AKLEASGGINESSLRRIAETGVDYISLGTLTKDIKAVDLSMR  279
            +++E SG I+ +++ R+   ++DY+S G+LT   K++D+SM+
Sbjct  242  SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

692) DND132_0380 in NC_016803


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (479),  Expect = 6e-32, Method: Compositional matrix adjust.
 Identities = 114/269 (43%), Positives = 170/269 (64%), Gaps = 4/269 (1%)

Query  20   ATIRIALAED--GSDLTSQGLFTESDMAQALIVAKQRTVVAGLPIIPLVLE-FGGKEC-Q  75
             T++ AL ED  + D +++++F + + A+  + AK+  V+AGL ++  V+  F++    Q
Sbjct  15   DTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQ  74

Query  76   AHLNVDDGETVSEGTMVAAIQGPAIQLLKAERVMLNFLCHLSGVANLTARYVEAlkgtkt  135
               +  DG+ ++ G +V  I G+   LL  ERV LNFL HLSG+A++TA YVEAL + + 
Sbjct  75   NPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI  134

Query  136  tlldtrktlPGLRFPEKYAVLAGGGRNHRLTLSDMLMLKDNHIDRAGSITEAVRQLRTVL  195
             ++DTRKT P LR+ EKYAV  GGG NHR+ LSD +MLKDNHI   GS+  A+ Q R+  
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  196  SPCPPIEVECRTLDDVKETSKLDVQRIMLDNMDAETARTALSMIPDAIETEISGNVSLET  255
            +    +EVE  +L    E++  +V+ IMLDNM  E    A+++I++    E SGN+ + T
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  256  IRDIAELGPDYISVGKLTHSAPSSDFSMQ  284
            I  +  L+ DY+S G LTHSA S DFSM+
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

693) Emtol_1417 in NC_018748


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  131 bits (479),  Expect = 6e-32, Method: Compositional matrix adjust.
 Identities = 112/278 (41%), Positives = 180/278 (65%), Gaps = 6/278 (2%)

Query  8    INKFIKAALAEDVGDGDHTSLSTVPTDAIGKAKLLVKDEGILAGVELAKMIFKIVDKDLK  67
            I+  +KAAL EDV   D ++ +    ++ +K  L+ K+ G+LAG+ + + +F + D ++ 
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  68   VQV--LIKDGKPVKYGDIAFYVEGRDRSILTAERLVLNCMQRMSGIATTTSQvvkllkgt  125
             Q    +KDG  +  GD+ + + G  RS+LT ER+ LN +Q++SGIA+ T+  V  L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  126  ktkvldtRKTTPCFRMIEKWGVQIGGGVNHRFGLFDMILIKDNHVDYAGGIKNALNAAHQ  185
            + KV+DTRKTTP +R++EK +V++GGG NHRF L D I++KDNH+   G++++A+  A+ 
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  186  YLKSTGKDLPIEIEVRNLTELQEALEIGGVVRIMLDNFSFENIREAIKIVDGRFPLEASG  245
            Y         +E+EV +L+   E    +GV  IMLDN S+E+I +AI ++ GR  +E SG
Sbjct  193  YAPFVKM---VEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  246  NISPKNVKEYADCGVDYVSMGYLTHSAKSLDLSLKAVK  283
            NI    +  + + ++DYVS G LTHSAKSLD+S+K++ 
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLT  286

694) NH44784_014371 in NC_021285


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (476),  Expect = 1e-31, Method: Compositional matrix adjust.
 Identities = 117/280 (42%), Positives = 189/280 (68%), Gaps = 3/280 (1%)

Query  30   PSLPDVMLEPLVRAALLEDLGRAGDLTTDAIVPADAVAQTRLVARQDGVlagldlarlaf  89
              L    ++  ++AAL ED+ ++ D +T+AI   ++ A+  L A++ GVLAGL + +  F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  90   raldpaMEFRVAQ--RDGAELAPGTEIATIRGNARAMLSAERVALNFLCHLSGVatatas  147
              +D+ + F+ ++  +DG  L++G  +  I G+ R++L+ ERVALNFL HLSG+A+ TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  148  iaraiaGHGARVTCTRKTMPGLRAVQKYAVRVGGGSNHRYGLDDAVLIKDNHIALAGSVE  207
               A++++  +V  TRKT P LR  +KYAVRVGGG NHR+ L DA+++KDNHIA  GSV+
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  208  TAVQRARASVGHMVKIELEVDTLAQLETalalgvdvvlldNMSLDELRQAVAMARGRAIT  267
             A+ +ARA    +  +E+EV++LA  E A A GVD+++LDNMSL+++ QA+++  GR+  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  268  EASGRITPDTaaavaaTGVDQIAVGWVTHSAKVLDIGLDA  307
            E SG I   T +   + ++D ++ G +THSAK LD+++ +
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

695) nadC in NC_013956


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 1e-31, Method: Compositional matrix adjust.
 Identities = 112/272 (42%), Positives = 182/272 (67%), Gaps = 5/272 (1%)

Query  33   VARALQEDLGGEVDSERDITAQLLPAESRAHARVITREAGVFCGKRWVEEVFNQLGAYTA  92
            +  +L+  L  +V+SE   T  ++  +++A   ++++EAGV+ G    + VF  ++A  +
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  93   L--TWHVEDGQTLTPDQLLFEIEGParllltaertalNFVQTLSGVATEVSRYVALLEGT  150
            +    +  DG+ LT+++L++EI G+ R LLT ER ALNF+Q LSG+A+  + YV  L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  151  QTQLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIRQAVEKASW  210
            + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+ +A +
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-R  191

Query  211  LYPDVP--VEVEVESLKELQDALAASADIVMLDNFTLDEMREAVKITEGRALLEVSGNVT  268
             Y+     VEVEVESL   ++A AA+ DI+MLDN +L+++ +A+ +  GR+ +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  269  ETTIREIAQTGVDYVSVGALTKHVHALDLSMR  300
             TTI  +   ++DYVS G+LT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

696) nadC in NC_004347


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (478),  Expect = 7e-32, Method: Compositional matrix adjust.
 Identities = 100/248 (41%), Positives = 168/248 (68%), Gaps = 9/248 (3%)

Query  46   AEATLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLVLPNQVLCELSGPARAL  103
            A  +L+++E GV+ G +  ++VF  +++EV+++   +  DGD + + +++ E+ G+ R+L
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  104  LTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKN  163
            LT ER A+NF+Q LSG+A++T  YV+ L++ + +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  164  HRIGLFDAFLIKENHIMACGGISQAVEAARRLHP-NKPveveveslselalalDSGTDII  222
            HR+ L DA+++K+NHI A G++ +A+  AR   P  K VEVEVESL+    A  +G DII
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  223  MLDNFDITMMVEAVELNNQYKMKGSGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHV  282
            MLDN  +  + +A+ L       ++ +++E SGN+ + T++ F   ++DY+S G+LT   
Sbjct  222  MLDNMSLEQIEQAITLI------AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSA  275

Query  283  RALDLSMR  290
            ++LD+SM+
Sbjct  276  KSLDFSMK  283

697) B932_2816 in NC_019396


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 8e-32, Method: Compositional matrix adjust.
 Identities = 108/268 (41%), Positives = 180/268 (68%), Gaps = 4/268 (1%)

Query  16   VRTALLEDLGTGGDVTTQALLDPKQPLQAIFRARKKGVLAGLQGAELAFTLLDKSVRFL-  74
            +++AL ED+  + D +T+A++D     +  + A+  GVLAGL   +  FTL+D  V F  
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  75   PQK-NDGEQIvagdvlavveggagavlsgeRTALNLLSHLSGIATATREIVDAVDGTNVR  133
            P++ +DG+++ +GD++  + G+  ++L+ ER ALN+L HLSGIA+ T   V+A+++  ++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  134  ICCTRKTLPGMKAVQKYAVRAGGGSSHRYRLDDAILIKDNHLALCGGVSAALAKARSRAG  193
            +  TRKT P ++  +KYAVR GGG +HR+ L DAI++KDNH+A  G+V  A+A+AR+ A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  194  HLMKIELEVDTLEQLEEALSAGGADAYLLDNMSSDQLRQAVRLIAGRGIAEASGGITPET  253
             +  +E+EV++L    E  +A+G D  +LDNMS +Q+ QA+ LIAGR+  E SG I   T
Sbjct  196  FVKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTT  254

Query  254  VRPIAETGVDIISLGWLTHTVRALDIGL  281
            +  +   ++D +S G LTH+ ++LD+++
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

698) D782_3763 in NC_020063


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 111/275 (41%), Positives = 177/275 (65%), Gaps = 4/275 (1%)

Query  24   PNAVAQALREDLGGEVDANNDITAQLLPAETRSHAVVITREDGVFCGKRWVEEVFIQLAG  83
            P  + ++L+  L  +V++++  T  ++  + ++   ++++E GV+ G    + VF  L +
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT-LFD  68

Query  84   DDVTL--TWHVEDGDLLKADQPLFEIDGPSRVLLTGERTALNFVQTLSGVASEVRRYVDL  141
             +VT+    +  DGD L +++ ++EI G+ R LLT ER ALNF+Q LSG+AS    YV+ 
Sbjct  69   AEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  142  LEGTKTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVE  201
            L + + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GSV++A+ 
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  202  KA-FWLHpdvpvevevenleeledALKAGADIIMLDNFDTELMRKAVAITKGQARLEVSG  260
            +A         VEVEVE+L   E+A  AG DIIMLDN   E + +A+++  G++R+E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  261  NVTFDTIREFAETGVDYISVGALTKHVRALDLSMR  295
            N+   TI  F   ++DY+S G+LT   ++LD+SM+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

699) nadC in NC_017531


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 182/272 (67%), Gaps = 5/272 (1%)

Query  27   VARALQEDLGGEVDSERDITAQLLPAESRAHARVITREAGVFCGKRWVEEVFNQLGAYTA  86
            +  +L+  L  +V+SE   T  ++  +++A   ++++EAGV+ G    + VF  ++A  +
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  87   L--TWHVEDGQTLTPDQLLFEIEGParllltaertalNFVQTLSGVATEVSRYVALLEGT  144
            +    +  DG+ LT+++L++EI G+ R LLT ER ALNF+Q LSG+A+  + YV  L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  145  QTQLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIRQAVEKASW  204
            + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+ +A +
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-R  191

Query  205  LYPDVP--VEVEVESLKELQDALTASADIVMLDNFTLDEMREAVKITEGRALLEVSGNVT  262
             Y+     VEVEVESL   ++A +A+ DI+MLDN +L+++ +A+ +  GR+ +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  263  ETTIREIAQTGVDYVSVGALTKHVHALDLSMR  294
             TTI  +   ++DYVS G+LT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

700) nadC in NC_016816


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 182/272 (67%), Gaps = 5/272 (1%)

Query  27   VARALQEDLGGEVDSERDITAQLLPAESRAHARVITREAGVFCGKRWVEEVFNQLGAYTA  86
            +  +L+  L  +V+SE   T  ++  +++A   ++++EAGV+ G    + VF  ++A  +
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  87   L--TWHVEDGQTLTPDQLLFEIEGParllltaertalNFVQTLSGVATEVSRYVALLEGT  144
            +    +  DG+ LT+++L++EI G+ R LLT ER ALNF+Q LSG+A+  + YV  L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  145  QTQLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIRQAVEKASW  204
            + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS+++A+ +A +
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-R  191

Query  205  LYPDVP--VEVEVESLKELQDALTASADIVMLDNFTLDEMREAVKITEGRALLEVSGNVT  262
             Y+     VEVEVESL   ++A +A+ DI+MLDN +L+++ +A+ +  GR+ +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  263  ETTIREIAQTGVDYVSVGALTKHVHALDLSMR  294
             TTI  +   ++DYVS G+LT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

701) Sput200_3559 in NC_017566


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 101/250 (41%), Positives = 169/250 (68%), Gaps = 11/250 (4%)

Query  46   AEATLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLILPNQVLCELSGPARSI  103
            A  +L+++E GV+ G +  ++VF  +++EV+++   +  DGD + + +++ E+ G+ RS+
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  104  LTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKN  163
            LT ER A+NF+Q LSG+A++T  YV+ L++ + +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  164  HRIGLFDAFLIKENHIMACGGIRQAVDAARNLHP-NKPveveveslselalalDSGTDII  222
            HR+ L DA+++K+NHI A G++++A+  AR   P  K VEVEVESL+    A  +G DII
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  223  MLDNFDITMMVEAVELNNQYRANGKAKGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTK  282
            MLDN  +  + +A+ L       G+   +++E SGN+ + T++ F   ++DY+S G+LT 
Sbjct  222  MLDNMSLEQIEQAITL-----IAGR---SRIECSGNIDMTTISRFRGLAIDYVSSGSLTH  273

Query  283  HVRALDLSMR  292
              ++LD+SM+
Sbjct  274  SAKSLDFSMK  283

702) Sputcn32_3421 in NC_009438


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 101/250 (41%), Positives = 169/250 (68%), Gaps = 11/250 (4%)

Query  46   AEATLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLILPNQVLCELSGPARSI  103
            A  +L+++E GV+ G +  ++VF  +++EV+++   +  DGD + + +++ E+ G+ RS+
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  104  LTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKN  163
            LT ER A+NF+Q LSG+A++T  YV+ L++ + +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  164  HRIGLFDAFLIKENHIMACGGIRQAVDAARNLHP-NKPveveveslselalalDSGTDII  222
            HR+ L DA+++K+NHI A G++++A+  AR   P  K VEVEVESL+    A  +G DII
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  223  MLDNFDITMMVEAVELNNQYRANGKAKGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTK  282
            MLDN  +  + +A+ L       G+   +++E SGN+ + T++ F   ++DY+S G+LT 
Sbjct  222  MLDNMSLEQIEQAITL-----IAGR---SRIECSGNIDMTTISRFRGLAIDYVSSGSLTH  273

Query  283  HVRALDLSMR  292
              ++LD+SM+
Sbjct  274  SAKSLDFSMK  283

703) Sputw3181_0522 in NC_008750


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  130 bits (477),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 101/250 (41%), Positives = 169/250 (68%), Gaps = 11/250 (4%)

Query  46   AEATLITREEGVFCGKAWAEQVFNQLGGEVALH--WHVDDGDLILPNQVLCELSGPARSI  103
            A  +L+++E GV+ G +  ++VF  +++EV+++   +  DGD + + +++ E+ G+ RS+
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  104  LTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKN  163
            LT ER A+NF+Q LSG+A++T  YV+ L++ + +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  164  HRIGLFDAFLIKENHIMACGGIRQAVDAARNLHP-NKPveveveslselalalDSGTDII  222
            HR+ L DA+++K+NHI A G++++A+  AR   P  K VEVEVESL+    A  +G DII
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  223  MLDNFDITMMVEAVELNNQYRANGKAKGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTK  282
            MLDN  +  + +A+ L       G+   +++E SGN+ + T++ F   ++DY+S G+LT 
Sbjct  222  MLDNMSLEQIEQAITL-----IAGR---SRIECSGNIDMTTISRFRGLAIDYVSSGSLTH  273

Query  283  HVRALDLSMR  292
              ++LD+SM+
Sbjct  274  SAKSLDFSMK  283

704) Fraau_2238 in NC_017033


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (474),  Expect = 1e-31, Method: Compositional matrix adjust.
 Identities = 115/272 (43%), Positives = 177/272 (66%), Gaps = 4/272 (1%)

Query  13   QIDRDVHAALTEDLGPGD-ATASLVPYETRATARLRCREAAVIAGTAWFDACFRRLDPEV  71
            QID  + AAL ED+ + D +T ++   + +A   L  +EA+V+AG + F+  F  +D+EV
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  72   EID--WTVRDGGQVEADSLICTLRGDARALLTAERSALNFLQLMSGTATRTADYARLVAG  129
             ++     +DG+++ ++ L+  + G  R+LLT ER ALNFLQ +SG A+ TA Y   +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  130  TGTRLLDTRKTVPGLRIAQKYAVACGGGVNHRFGLYDAILIKENHILaaggiaaavkkaR  189
               +++DTRKT P LR+ +KYAV  GGG NHRF L DAI++K+NHI A G++  A+ +AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  190  QQHP-AlplevevenldeleQAIAAGVDRIMLDNFELEQIRAAVAHTAGRVPLEVSGNAE  248
               P    +EVEVE+L   E+A AAGVD IMLDN  LEQI  A++  AGR  +E SGN +
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  249  REHLQAIAETGVDFISIGALTKHVRAIDFSLR  280
               +  +   ++D++S G+LT   +++DFS++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

705) nadC in NC_009257


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (474),  Expect = 1e-31, Method: Compositional matrix adjust.
 Identities = 85/205 (42%), Positives = 145/205 (71%), Gaps = 1/205 (0%)

Query  81   YSDAQKVPANARIFELKGNARSILTAERTILNFIQMLSGTATVTNKQVKLISQYKTKLLD  140
            + D++++ +   ++E+ G+ RS+LT ER  LNF+Q LSG A++T   V  +++ + K++D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  141  TRKTIPGFRLAQKYAVRCGGGFNHRIGLFDAYLIKENHIRSAGGIAKAVTKAKKLDS-NK  199
            TRKT P +RL +KYAVR GGG+NHR+ L DA ++K+NHI + G++ KA+++A+   +  K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  200  VVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIARGKVALEVSGNIDRNSIVAI  259
            +VEVEV +L   ++A AA  DI+MLDN S E+I+ A+++  G+  +E SGNID  +I  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  260  AKTGVDFISVGAITKHIKAIDLSLQ  284
               ++D++S G++T   K++D+S++
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

706) S58_32030 in NC_020453


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (472),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 119/267 (45%), Positives = 186/267 (70%), Gaps = 3/267 (1%)

Query  15   VRAALLEDLGRAGDITTDAIVPRERHASLKLRARQHGVIAGLDVARCAFQTVSPDVRMEI  74
            ++AAL ED+ ++ D +T+AI  ++ +A + L A++ GV+AGL V +  F    ++V  + 
Sbjct  17   LKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  75   TRP--DGSAVAPGDMIATISGPARALLTGERVALNFLCHlsgvasatallvaavKGTRAQ  132
             +   DG  +++GD++  I G+ R+LLT ERVALNFL HLSG+AS TA  V A+ + R +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  133  IVCTRKTTPGLRALEKYAVRAGGGGNHRFGLDDAVLIKDNHiaiaggikaaivsakaHAG  192
            +  TRKTTP LR +EKYAVR GGG NHRF L DA+++KDNHIA  G+++ AI  A+A A 
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  193  HLVKIEVEVDTLAQleealalgvdavlldNMTPAELERAVGIIGGKAIAEASGRITVETA  252
             +  +EVEV++LA  EEA A GVD ++LDNM+  ++E+A+ +I+G++  E SG I + T 
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  253  PAIAAAGVDLISVGWITHSSAALDIGL  279
            + + + ++D +S G +THS+ +LD+++
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSM  282

707) Mmah_1982 in NC_014002


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (472),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 105/243 (44%), Positives = 155/243 (64%), Gaps = 11/243 (4%)

Query  33   IFAKQDCVVAGVEVAEAIFDYFDIEYT----RKIAEGEKIQNNGVVFELKGRTVSLLRAE  88
            +FAK+  V+AG+ V + +F  FD E T    +++ +G+++ + ++V+E+ G   SLL  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  89   RLALNFLGHLSGIATLTRDCVEAVHECSEAVVAATRKTTPGIREFEKLAVIAGGGDPHRF  148
            R+ALNFL HLSGIA++T   VEA+ +     V  TRKTTP +R FEK AV  GGG  HRF
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGD-DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRF  164

Query  149  NLSDSIMIKDNHRHIMG-LENAILKAKEMASFTQKIEAEVESANDALLAARMGVDIVMLD  207
            NLSD+IM+KDNH   +G +++AI +A+  A+F + +E EVES   A  AA  GVDI+MLD
Sbjct  165  NLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLD  224

Query  208  NMSPSEIISTVEKLRHEGLRNKVIVEVSGGINTENLAEYAKTGIDVISMGSLIHKAQWAD  267
            NMS  +I  ++       +  +  +E SG I+   ++ +   +ID +S GSL H A+  D
Sbjct  225  NMSLEQIEQAITL-----IAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD  279

Query  268  LSM  270
            +SM
Sbjct  280  FSM  282

708) Deima_2834 in NC_014958


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (471),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 111/259 (43%), Positives = 174/259 (68%), Gaps = 10/259 (3%)

Query  20   DATTRATIPAEQSGHATFLLKQDGVLSGLPAAARAFTLLDARTQVTWHA----HEGEMHP  75
            D +T A +  +  +  +++ K+ GVL+GL    R FTL+DA  +VT +      +G+   
Sbjct  29   DYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA--EVTFQNPHQFKDGDRLT  86

Query  76   RGTVLGEVRGPLHALLGAERVALNLLQRASGVATFTRAHVDALAGtrtrlldtrkttplW  135
             G ++ E+ G++++LL  ERVALN+LQ+ SG+A+ T A V+AL++ R +++DTRKTTP  
Sbjct  87   SGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNL  146

Query  136  RDLEKQATRHGGAVNHRAGLDDGILIKDNHIAAVGSVRAAVQRARE-SAYLLKVECEVTD  194
            R +EK A R GG+ NHR  L D+I++KDNHIAAVGSV+ A+ +AR  ++++  VE EV  
Sbjct  147  RLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVES  206

Query  195  LNGLREALDAGADRVLLDNMRDDLIAQAVAVRDECAPHVTLEASGNMTLARLPRVAATGV  254
            L +  EA  AG D ++LDNM  + I QA+++    A +  +E SGN+ ++ ++R  + ++
Sbjct  207  LAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRFRGLAI  263

Query  255  DYVSVGGLTHSAPSLDISL  273
            DYVS G+LTHSA SLD+S+
Sbjct  264  DYVSSGSLTHSAKSLDFSM  282

709) HY04AAS1_1050 in NC_011126


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (473),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 114/277 (42%), Positives = 183/277 (67%), Gaps = 6/277 (2%)

Query  1    MNWLKIDEAIKSFLEEDIGWGDITSSGLPDDL-NAKGFIKIKESGVVSGLFFAKRVFELL  59
            +  ++ID+++K+ L ED+   D +++++ D+  +AK  +  KE+GV++GL   +RVF L+
Sbjct  8    LTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLF  67

Query  60   GIKEIILKA---KDGDLVNKKDITMELQGNAKALLMGERVALNLIQSLSGIATETKFMLD  116
            +    + ++   KDGD +   D+ +E+ G+ ++LL  ERVALN++Q LSGIA+ T   ++
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  117  KIKDYEVKLLDTRKTTPGYRFFEKYAVRTGAGTNHRFALYDMVLIKDNHINLYGSISKAV  176
             + D  +K++DTRKTTP  R+FEKYAVR G+G NHRF L D +++KDNHI   GS+ KA+
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  177  QEIRKNLSMAYKVEVEVSNFEQLEEAlnldidmilldnFGVEDAKKAIELIRKRSSIKIE  236
             + R   +    VEVEV ++   EEA   ++D+I+LDN ++E+  +AI LI  RS  +IE
Sbjct  188  AQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS--RIE  245

Query  237  LSGEINKDNIETYAKTRPDYISSGAIIHSSKWLNASM  273
             SG+I+   I  +     DY+SSG++ HS+K L+ SM
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

710) Fbal_0365 in NC_014541


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (472),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 100/246 (41%), Positives = 165/246 (68%), Gaps = 7/246 (2%)

Query  39   AEATIITREDGVFCGKAWAEQVFNQLGGDVALH--WHVDDGDLVVAGQTLCELAGPARLL  96
            A  +++++E GV+ G +  ++VF  ++++V+++   +  DGD + +G+ + E+ G+ R L
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  97   LTGERTVLNFIQTLSGVATTVSHYVAKLEGTQTRLLDTRKTLPGLRTAQKYAVTCGGGHN  156
            LT ER  LNF+Q LSG+A+  + YV  L + + +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  157  HRIGLFDAFLIKENHIAACGGISPAIAAARQL-RpeapvevevenleelkealTGGADIV  215
            HR+ L DA+++K+NHIAA G++  AIA AR        VEVEVE+L    EA ++G DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  216  MLDNFDITMMLDAVTLNREQFEGRCKLEVSGDVTLATIGDFARTGVDFISVGALTKHVKA  275
            MLDN  +  + +A+TL    + GR ++E SG++ ++TI+ F   ++D++S G+LT   K+
Sbjct  222  MLDNMSLEQIEQAITL----IAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKS  277

Query  276  MDLSMR  281
            +D+SM+
Sbjct  278  LDFSMK  283

711) Psed_2847 in NC_015312


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  129 bits (471),  Expect = 3e-31, Method: Compositional matrix adjust.
 Identities = 104/238 (44%), Positives = 165/238 (70%), Gaps = 5/238 (2%)

Query  60   PRRAGVLAGLPVARAVLDEVLGGE--WEEMAALEDGASLTAGEPALVVRAPVRGLLTAER  117
            ++ AGVLAGL V + V+  ++++E   ++   + DG  LT+G+  L + ++VR+LLT ER
Sbjct  48   AKEAGVLAGLTVFQRVFT-LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCER  106

Query  118  TALNLLCHLSGVATATRAWVDALAGTPARVRDTRKTLPGLRLLEKYAVRCGGGVNHRLGL  177
             ALN+L HLSG+A+ T A V+AL++   +V DTRKT P LRL+EKYAVR GGG NHR+ L
Sbjct  107  VALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNL  166

Query  178  GDAVLIKDNHvaaagsvsaalaaaralaPDLP-CEVEVDSLDQLDDVLALGAELVLLDNF  236
            +DA+++KDNH+AA GSV  A+A ARA AP +   EVEV+SL   ++  A G ++++LDN 
Sbjct  167  SDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNM  226

Query  237  TPAQTAEAVRRRGASPTLLESSGGIVLadaaayaaTGVDFISVGALTHSVTALDLGLD  294
            +  Q  +A+   ++ +  +E SG I ++  + + + ++D++S G+LTHS  +LD+++ 
Sbjct  227  SLEQIEQAITLIAGRSR-IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

712) AnaeK_1475 in NC_011145


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  128 bits (469),  Expect = 3e-31, Method: Compositional matrix adjust.
 Identities = 111/253 (44%), Positives = 178/253 (71%), Gaps = 6/253 (2%)

Query  26   TSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFERLGASCTFdradgara----argev  81
            +++A +D  + +   ++AKE  VLAG +V  RVF  ++A  TF+ ++  +     + G++
Sbjct  31   STNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDL  90

Query  82   vgtargTVRALLAAERTALNFLQRLSGVATATRRCADALAAGGGRTRLLDTRKTTPGWRM  141
            V    G+VR+LL+ ER ALNFLQ+LSG+A+ T    +AL  G++R +++DTRKTTP  R+
Sbjct  91   VLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRL  148

Query  142  LEKAAVRAGGGKNHRFSLGDGVLIKDNHvaacggvaeavrrarasagaMLRVEVEVEDLP  201
            +EK AVR GGG NHRF+L+D++++KDNH+AA G+V  A+ +ARA A  +  VEVEVE L+
Sbjct  149  FEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLA  208

Query  202  GLEEAIAAGADLVLLDNMDDGAMAEAVRRTAGRALLEASGNMTLERLPRVAATGVDFVSM  261
            + EEA AAG D+++LDNM    + +A+   AGR+ +E SGN+ +  ++R  + ++D+VS 
Sbjct  209  AAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSS  268

Query  262  GAVTHSARAVDVA  274
            G++THSA+++D +
Sbjct  269  GSLTHSAKSLDFS  281

713) PputGB1_0821 in NC_010322


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  128 bits (470),  Expect = 3e-31, Method: Compositional matrix adjust.
 Identities = 115/278 (42%), Positives = 196/278 (71%), Gaps = 5/278 (1%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITREDCVIAGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK +++++E  V+AG +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVADGERATANQPLFHLEGPARSLLSGERSALNFLQMLSGVATRARFL  122
             +D+ V+ +   Q  DG+R T+ + ++++ G+ RSLL+ ER ALNFLQ LSG+A+ +   
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  123  ADLVADTQVRLLDTRKTLPGLRLAQKYAVTCGGCDNHRIGLYDAFLIKENHIaasggvaq  182
             + ++D +++++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G+V +
Sbjct  126  VEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQK  185

Query  183  avaaaHRIAP-GKPVeievesleelrealaagaDIIMLDELNLDEMREAVRINAGKAKLE  241
            A+A A+  AP  K VE+EVESL    EA AAG DIIMLD+++L+++ +A+ + AG++++E
Sbjct  186  AIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIE  245

Query  242  ASGGVNETTLRVIAETGVDYISIGAMTKDVKAVDLSMR  279
             SG ++ TT+  +   ++DY+S G++T   K++D+SM+
Sbjct  246  CSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

714) PAGR_g3462 in NC_017554


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  128 bits (470),  Expect = 3e-31, Method: Compositional matrix adjust.
 Identities = 111/272 (41%), Positives = 180/272 (67%), Gaps = 5/272 (1%)

Query  27   VARALQEDLGGEVDSERDITAQLLPAESRAHARVITREAGVFCGKRWVEEVFNQLGAYTA  86
            +  +L+  L  +V+SE   T  ++  +++A   ++++EAGV+ G    + VF  ++A  +
Sbjct  13   IDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVT  72

Query  87   L--TWHVEDGQTLTPDQLLFEIEGParllltaertalNFVQTLSGVATEVRRYVALLEGT  144
            +    +  DG+ LT+++L++EI G+ R LLT ER ALNF+Q LSG+A+    YV  L + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  145  QTQLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIREAVEKASW  204
            + +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GS++ A+ +A +
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA-R  191

Query  205  LYPDVP--VEVEVESLKELQDALTASADIVMLDNFTLDEMREAVKITEGRALLEVSGNVT  262
             Y+     VEVEVESL   ++A +A+ DI+MLDN +L+++ +A+ +  GR+ +E SGN+ 
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  263  ETTIQEIAQTGVDYVSVGALTKHVHALDLSMR  294
             TTI  +   ++DYVS G+LT    +LD+SM+
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

715) Pat9b_0681 in NC_014837


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  128 bits (470),  Expect = 3e-31, Method: Compositional matrix adjust.
 Identities = 112/274 (41%), Positives = 180/274 (66%), Gaps = 3/274 (1%)

Query  24   PEAVARALQEDLGGEVDADRDITALLLPADKQAEAKIITREAGVFCGKRWVEEVFIQLGN  83
            P  +  +L+  L  +V+++   T  ++  + QA   ++++EAGV+ G    + VF  ++ 
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  84   KVTI--TWHVEDGQVLVADQLLFELQGParllltaertalNFVQTLSGVATEVSHYVALL  141
             VT+    +  DG+ L +++L++E+ G+ R LLT ER ALNF+Q LSG+A+  + YV  L
Sbjct  70   EVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL  129

Query  142  AGSNTQLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSVRQAVEK  201
            ++   +++DTRKT P LR   KYAV  GGG NHR+ LSDA+++K+NHI A GSV++A+ +
Sbjct  130  GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQ  189

Query  202  ALWLQPDVP-VEVEVETLDELQAALAAGADIVMLDNFTLEMMRKAAALTQRRALLEVSGN  260
            A    P V  VEVEVE+L   + A AAG DI+MLDN +LE + +A +L   R+ +E SGN
Sbjct  190  ARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGN  249

Query  261  VTAATLPQIAQTGVDYVSVGALTKHVRALDLSMR  294
            +  +T++++   ++DYVS G+LT   ++LD+SM+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

716) DvMF_0524 in NC_011769


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  128 bits (469),  Expect = 4e-31, Method: Compositional matrix adjust.
 Identities = 107/267 (41%), Positives = 161/267 (61%), Gaps = 9/267 (3%)

Query  32   DGPDLTSDAVFGPVDRLAAQIVAKQQTLVAGLPIAPLVMERCAALLESPVVGGWTWTPHT  91
            ++ D +++A+F+  ++    + AK+  ++AGL     V +R  +L+++ V        + 
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLT----VFQRVFTLFDAEV--TFQNPHQF  79

Query  92   ADGDELPSGFIAADIEGPARLVLKAERVILNFVCHLSGIANLTRRYTRELDGTSTRLLDT  151
             DGD L SG +  +I G+ R +L  ERV LNF+ HLSGIA++T  Y   L++   +++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  152  RKTLPGLRFPEKYAVLVGGGQNHRRTLAEMLMLKDNHIDAAGSITaavaalraayaPCPP  211
            RKT P LR+ EKYAV VGGG NHR  L++ +MLKDNHI A GS+  A+A  RA  +    
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  212  IEVECRTLDEVREAVACTVDRIMLDNMDLALLRESLTVVPPGIETEASGGITLETLRQLA  271
            +EVE  +L    EA A  VD IMLDNM L  + +++T+++     E SG I + T+ ++ 
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF-  258

Query  272  EASPHGPDFVSVGRLTHSAPVADFSMR  298
                 + D+VS G LTHSA   DFSM+
Sbjct  259  --RGLAIDYVSSGSLTHSAKSLDFSMK  283

717) AHML_20490 in NC_021290


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  128 bits (467),  Expect = 5e-31, Method: Compositional matrix adjust.
 Identities = 105/242 (44%), Positives = 164/242 (68%), Gaps = 3/242 (1%)

Query  45   ASARVITREAGVFCGQPWVDEVFVQLGGEVRVE--WLVQDGEVLFPNQELFRLHGPARVL  102
            A   ++++EAGV+ G    + VF  +++EV  +     +DG+ L + + ++ + G+ R L
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  103  LTGERNALNFVQTLSGVASLTARYVAELADTDCRLLDTRKTLPGLRSAQKYAVTCGGGKN  162
            LT ER ALNF+Q LSG+AS+TA YV  L+D   +++DTRKT P LR  +KYAV  GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  163  HRIGLFDAYLIKENHILACGGIAEAINEARRLNP-GKPveveveslveleqalaasaDIV  221
            HR+ L DA ++K+NHI A G++  AI +AR   P  K VEVEVESL   E+A AA+ DI+
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  222  MLDNFDIPMMREAVALNQGRAKLEVSGNVTLDTLADYAATGVDFISVGALTKHVRALDLS  281
            MLDN  +  + +A++L  GR+++E SGN+ + T++ + + ++D++S G+LT   ++LD+S
Sbjct  222  MLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

Query  282  MR  283
            M+
Sbjct  282  MK  283

718) Hneap_2251 in NC_013422


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  127 bits (466),  Expect = 6e-31, Method: Compositional matrix adjust.
 Identities = 110/273 (41%), Positives = 178/273 (66%), Gaps = 6/273 (2%)

Query  6    QIADDVTRALTEDIGGGDVSARLVPAEQMMQGRI--VARESCVLAGTAWAETAFRRVSNR  63
            QI D +  AL ED+ + D S+  +  ++  Q+++   A+E+ VLAG +  +  F      
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAI-FDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  64   SLVQ--WLYCDGDPVPADSVICTLDGParalltaertalNFLQTLSGTATITRAYVDAIS  121
               Q    + DGD + ++ ++  + G+ R+LLT ER ALNFLQ LSG A++T AYV+A++
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  122  GTSARILDTRKTIPGLRMAQKYAVTCGGGFNHRLGLYDMVLLKENHIMAAGSITAAVQAS  181
            +   +++DTRKT P LR+ +KYAV  GGG+NHR+ L D ++LK+NHI A GS+  A+  +
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  182  RAINPDVPL-EVEVETLDQLEEALAAGVDRILLDNFDLAGLRAAVAANKGRAKLEASGNV  240
            RA  P V + EVEVE+L   EEA AAGVD I+LDN  L  +  A++   GR+++E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  241  DLSTVRDVALTGVDFISTGAITKHVQAIDLSLR  273
            D++T+      ++D++S+G++T   +++D+S++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

719) PSEBR_a784 in NC_015379


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  127 bits (464),  Expect = 9e-31, Method: Compositional matrix adjust.
 Identities = 116/279 (42%), Positives = 199/279 (72%), Gaps = 7/279 (2%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRDAAIISGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK ++++++A++++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVRDGDRVNPDQALFHLEGPARSLLTGERSALNFLQMLSGVAT-RARY  121
             +D+ V+ +   Q +DGDR+ +++ ++++ G+ RSLLT ER ALNFLQ LSG+A+  A Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  LADFVAGTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaacggia  181
            +   +++ ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ 
Sbjct  126  VEA-LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  qaiaaa-hkiapgKPveveveslaelkealaanaDIIMLDELSLDDMREAVRLNGGKAKL  240
            +AIA A    +  K VEVEVESLA   EA AA  DIIMLD++SL+++ +A+ L +G++++
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  241  EASGGINESTLRPIAETGVDYISIGAMTKDVKAVDLSMR  279
            E SG I+ +T+  +   ++DY+S G++T   K++D+SM+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

720) SCE1572_15415 in NC_021658


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  126 bits (462),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 102/235 (44%), Positives = 158/235 (68%), Gaps = 7/235 (2%)

Query  47   VVCGGDVFLRVFQRLDPQV--EGEVLIADGTSVDTGAVLWTVRGLARTLLSAERTALNFA  104
            V+ G  VF RVF  +D++V  +    + DG  + +G ++  + G  R+LL+ ER ALNF 
Sbjct  53   VLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFL  112

Query  105  QRMSGVASEARRYAAAIPQGSGVRITDTRKTTPGLRALERYAVRVGGAHNHRDSLGSAVL  164
            Q++SG+AS +  Y  A+ ++  +++ DTRKTTP LR +E+YAVRVGG+ NHR +L+ A++
Sbjct  113  QHLSGIASMTAAYVEALGDDR-IKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIM  171

Query  165  IKDNHivaaggiataigrararaPHTTKIEVEVASLRELDEALSAGADIIMLDNFTLADV  224
            +KDNHI A G++  AI++ARA AP    +EVEV SL   +EA +AG DIIMLDN +L ++
Sbjct  172  LKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQI  231

Query  225  KTASARVRSAQHGRPLLEVSGGITLERIPELAAAGIDIISVGALTHSARSADIAL  279
              A + +     GR+ +E SG I +  I+ + + +ID +S G+LTHSA+S D+++
Sbjct  232  EQAITLI----AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

721) B565_0360 in NC_015424


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  126 bits (463),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 103/244 (43%), Positives = 164/244 (68%), Gaps = 3/244 (1%)

Query  45   ASARVITREAGVFCGQPWVDEVFLQLKAQLGGEVKVEWLVQDGEVLSPNQELFRLHGPAR  104
            A   ++++EAGV+ G    + VF  + A++  +   +   +DG+ L++ + ++ + G+ R
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQF--KDGDRLTSGDLVLEIIGSVR  99

Query  105  LLLTGERNALNFVQTLSGVATLTARYVAELEGTDCRLLDTRKTIPGLRTAQKYAVTCGGG  164
             LLT ER ALNF+Q LSG+A++TA YV  L +   +++DTRKT P LR  +KYAV  GGG
Sbjct  100  SLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGG  159

Query  165  KNHRIGLYDAYLIKENHILACGGIAEAINEARHLNP-GKPveveveslaeleqalaakaD  223
             NHR+ L DA ++K+NHI A G++  AI +AR   P  K VEVEVESLA  E+A AA  D
Sbjct  160  YNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVD  219

Query  224  IVMLDNFDVTMMREAVAINQGRAKLEVSGNVTLDTLAEFAATGVDFISVGALTKHVRALD  283
            I+MLDN  +  + +A+++  GR+++E SGN+ + T++ F + ++D++S G+LT   ++LD
Sbjct  220  IIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLD  279

Query  284  LSMR  287
            +SM+
Sbjct  280  FSMK  283

722) bglu_1g28710 in NC_012724


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  126 bits (463),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 93/230 (41%), Positives = 157/230 (69%), Gaps = 3/230 (1%)

Query  63   LCGVPWFEAVMRAIDPSIEVD--WRYREGELMEADATVCELRGPARALLTAERNGLNFLQ  120
            L G+  F+ V   +D+ +  +   ++++G+ + ++  V E+ G+ R+LLT ER +LNFLQ
Sbjct  54   LAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQ  113

Query  121  LLSGVASATRRYVDLIDGHRGRILDTRKTLPGLRLAQKYAVRVGGGANQRLALYDGILIK  180
             LSG+AS T  YV+ ++++R +++DTRKT P LRL +KYAVRVGGG N+R+ L D+I++K
Sbjct  114  HLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLK  173

Query  181  ENHIaaaggvgaaldaafaLQSGVP-VQIEVETLAQLDTALAHGAKSVLLDNFTFEMMRE  239
            +NHIAA G+V  A+  A A  + V  V++EVE+LA  + A A G   ++LDN ++E + +
Sbjct  174  DNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQ  233

Query  240  AVRIASGRAVLEVSGGVNADTVVEIASTGVDRISIGALTKDVRATDFSMR  289
            A+ + +GR+ +E SG ++  T+  + + ++D +S G+LT   ++ DFSM+
Sbjct  234  AITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

723) FN3523_0644 in NC_017449


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  126 bits (462),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 84/205 (41%), Positives = 142/205 (70%), Gaps = 1/205 (0%)

Query  81   YSDAQKVPANAKIFELKGNARSILTAERTMLNFIQMLSATATATNNLVKLISQYDTKLLD  140
            + D++++ +   ++E+ G+ RS+LT ER  LNF+Q LS+ A+ T   V  +++   K++D
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD  138

Query  141  TRKTIPGFRLAQKYAVRCGGGFNHRIGLFDAYLIKENHIRSAGGIAKAVTKAKKIDT-SK  199
            TRKT P +RL +KYAVR GGG+NHR+ L DA ++K+NHI + G++ KA+++A+      K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  200  VIEVEVTNLDELNQAIAAKADIVMLDNFSIEDIHTAVSVARGKVALEVSGNIDDKSIVIM  259
            ++EVEV +L   ++A AA  DI+MLDN S+E+I+ A+++  G+  +E SGNID  +I   
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  260  AKTGIDFISVGAITKHIKAIDLSLQ  284
               +ID++S G++T   K++D+S++
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

724) Metho_0367 in NC_019977


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  126 bits (460),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 104/245 (43%), Positives = 156/245 (64%), Gaps = 15/245 (6%)

Query  33   ILAKEYCTLAGIDVAMSIFKYFG----LQAVPSHSDGDQVQAGNTIISLRGSSVSILRAE  88
            ++AKE   LAG+ V   +F  F+    +Q      DGD++ +G+ ++ + GS  S+L  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  89   RLSLNFLGHLSGIATMTSKCVQIVRSFSDTRVAC--TRKTIPGMRSLEKMAVVAGGGDTH  146
            R++LNFL HLSGIA+MT+  V+   +++D R+    TRKT P +R +EK AV  GGG  H
Sbjct  106  RVALNFLQHLSGIASMTAAYVE---ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNH  162

Query  147  RFSLSDCIMLKDNHITLMG-FEAAISEAKKRASFTQKIEVEVESMEEALLVARMGVDIIM  205
            RF+LSD IMLKDNHI+ +G  + AI++A+  A+F + +EVEVES+  A   A  GVDIIM
Sbjct  163  RFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIM  222

Query  206  LDNMSPTEVLRTVQKIKKEGLKEHVIIEVSGNITIENLEEYAKTGVDVISMGSLIHAARW  265
            LDNMS  ++ +++  I       +  IE SGNI +  +  +   ++D +S GSL H+A+ 
Sbjct  223  LDNMSLEQIEQAITLI-----AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKS  277

Query  266  IDLSM  270
            +D+SM
Sbjct  278  LDFSM  282

725) FNFX1_0700 in NC_017450


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  126 bits (461),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 85/212 (41%), Positives = 146/212 (69%), Gaps = 1/212 (0%)

Query  74   NIQITWLYNDAQKVPANARIFELKGNARSILTAERTILNFIQMLSATATATNKLVKLISQ  133
             +Q    ++D++++ +   ++E+ G+ RS+LT ER  LNF+Q LS+ A+ T   V  +++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  134  YNTKLLDTRKTIPGFRLAQKYAVRCGGGFNHRIGLFDAYLIKENHIRSAGGIVKAVTKAK  193
               K++DTRKT P +RL +KYAVR GGG+NHR+ L DA ++K+NHI + G++ KA+++A+
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  194  KLDS-NKVVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIARGKVALEVSGNID  252
               +  K+VEVEV +L   ++A AA  DI+MLDN S E+I+ A+++  G+  +E SGNID
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  253  RNSIVAIAKTGVDFISVGAITKHIKAIDLSLQ  284
              +I  +   ++D++S G++T   K++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

726) nadC in NC_017374


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  125 bits (459),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 87/211 (42%), Positives = 139/211 (66%), Gaps = 3/211 (1%)

Query  61   AQNIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
            ++++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMSAGADIVMCDNMSVGETKEIAAYREAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A +AG DI+M DNMS+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESISAYAKSGVDAISVGALIHQATFIDMHMK  271
             +IS +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

727) nadC in NC_017381


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  125 bits (459),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 87/211 (42%), Positives = 139/211 (66%), Gaps = 3/211 (1%)

Query  61   AQNIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
            ++++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMSAGADIVMCDNMSVGETKEIAAYREAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A +AG DI+M DNMS+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESISAYAKSGVDAISVGALIHQATFIDMHMK  271
             +IS +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

728) Halxa_1866 in NC_015666


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  125 bits (458),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 107/265 (41%), Positives = 168/265 (64%), Gaps = 13/265 (4%)

Query  11   LREDVGHHDVTNEV----PGETTGRLVAKESGVAAGLEAAASVFEYLGVDVV----DRLE  62
            LREDV  +D + +      G++   L AKE+GV AGL     VF  ++ +V     +++ 
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  63   DGTTLEEGDGLLQVEGAARDVLRGERVAVNLAGHASGIATRTRRVVDEARVESDDVRIAA  122
            DG  L  GD +L++ G+ R +L  ERVA+N+  H SGIA+ T   V+   +  D +++  
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA--LGDDRIKVFD  138

Query  123  TRKTTPGLRGLEKRAVVAGGGDTHRLDLSHMVMVKDNHVAEMG-LEDAIAHFQERTSFAT  181
            TRKTTP LR +EK AV  GGG  HR++LS+ +M+KDNH+A +G ++ AIA+ +  ++F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  182  KLDVEVETVadapraadagadIVLLDNMTPAETREAVDALADYEGVLAEASGGITLETVA  241
             ++VEVE++A A  AA AG DI++LDNM+  +  +A+  +A+   +  E SG I + T++
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI--ECSGNIDMTTIS  256

Query  242  DYAATGVDVISMGSLTHSAPSLDLS  266
             + + ++D +S GSLTHSA SLD+S
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFS  281

729) Mvan_2800 in NC_008726


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  125 bits (458),  Expect = 3e-30, Method: Compositional matrix adjust.
 Identities = 93/213 (44%), Positives = 147/213 (70%), Gaps = 4/213 (1%)

Query  72   YRVGHRVADGTRLEAGGVALTVEGPTRGLLTAERTLLNLVCHLSGIATATAAWVDAVSGT  131
            ++  H+  DG RL +G++ L + G+ R+LLT ER  LN++ HLSGIA+ TAA V+A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  132  GAQIRDTRKTLPGLRALQKYAVRVGGGTNHRMGLGDAALIKDNHVAAAGSVVAALRQVRS  191
              ++ DTRKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+ Q R+
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  192  AAPDLP-CEVEVDSleqldevlaedvelvlldNFPVWQTQIAVQRRDARSPKTKLESSGG  250
             AP +   EVEV+SL   +E  A +V++++LDN ++ Q + A+    +RS   ++E SG 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGN  249

Query  251  LALENAADYAGTGVDYLAVGALTHSVRVLDLGL  283
            + +   + + G ++DY++ G+LTHS + LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

730) hp908_1359 in NC_017357


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  125 bits (457),  Expect = 3e-30, Method: Compositional matrix adjust.
 Identities = 87/211 (42%), Positives = 139/211 (66%), Gaps = 3/211 (1%)

Query  61   AQNIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
            ++++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMSAGADIVMCDNMSVRETKEIAAYREAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A +AG DI+M DNMS+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESISAYAKSGVDAISVGALIHQATFIDMHMK  271
             +IS +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

731) LD85_1338 in NC_013769


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (455),  Expect = 4e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 164/264 (63%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVSELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   ++ + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

732) nadC in NC_022130


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 5e-30, Method: Compositional matrix adjust.
 Identities = 86/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QNIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHEVRL  121
            +++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  + +++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHHPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

733) Srot_0710 in NC_014168


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 86/206 (42%), Positives = 137/206 (67%), Gaps = 6/206 (2%)

Query  83   DGDRIAPGDSALSVTAPLQGILTAERTLLNFLCHLSGVATATAQWADQLTGTRAAVRDTR  142
            DGDR+++GD  L + ++++++LT ER  LNFL HLSG+A+ TA   + L + R  V DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  143  KTLPGLRLLQKHAVLCGGGANHRMGLGDAALVKDNHVAAAGSASEALRRVRARFPQLA--  200
            KT P LRL++K AV  GGG NHR  L+DA ++KDNH+AA GS   A+ + RA ++ +   
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA-YAPFVKM  199

Query  201  VEVEVDTLAQLAEILDEGAELVLLDNFDVETTRKAVALRDARSPttllessggltlatAR  260
            VEVEV++LA   E    G ++++LDN  +E   +A++L  +RS      + +  T++  R
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFR  259

Query  261  AYAETGVDFLAVGALTHSAKALDLGL  286
            +    ++D+++ G+LTHSAK+LD+++
Sbjct  260  G---LAIDYVSSGSLTHSAKSLDFSM  282

734) nadC in NC_012973


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (453),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 86/211 (41%), Positives = 136/211 (65%), Gaps = 3/211 (1%)

Query  61   TQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
             + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESINAYAKSGVDAISVGALIHQATFIDMHMK  271
             +I+ +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

735) nadC in NC_000921


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (453),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 86/210 (41%), Positives = 137/210 (66%), Gaps = 3/210 (1%)

Query  62   QNIKDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSPKVRL  121
            +++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL   ++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMSAGADIVMCDNMSVGETKEIAAYREAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A +AG DI+M DNMS+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

736) SiH_1175 in NC_017275


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

737) LS215_1316 in NC_012589


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

738) M1425_1224 in NC_012588


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

739) M164_1208 in NC_012726


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

740) SiRe_1091 in NC_017276


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

741) YG5714_1213 in NC_012622


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

742) YN1551_1634 in NC_012623


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (454),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 108/264 (41%), Positives = 163/264 (62%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIKARGVVKCKDSGILAG-NRFVIPFLNY---LGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG   F   F  +   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGSEVNKGDVVLLFEGNA-DVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISG  126
            DG  +  GD+VL + G+   +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD--DRIKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKSSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHIA  G+++  I + ++  +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITPDNVVDY  246
            ++EVEV S   A  A  AG D I+LDNM   +I   +  + G+  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  ARTGVDIISSGYTTHSSRSLDFSL  270
               ++D +SSG  THS++SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

743) HPIN_07120 in NC_017372


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (452),  Expect = 7e-30, Method: Compositional matrix adjust.
 Identities = 88/211 (42%), Positives = 137/211 (65%), Gaps = 3/211 (1%)

Query  61   TQTIKDKERFKSKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
             + +KD +R+ S D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETEEIAAYRDAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A  AG DI+M DNMS+ + E+  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESINAYVKSGVDAISVGALIHQATFIDMHMK  271
             +I+ +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

744) HPGAM_07015 in NC_017371


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (452),  Expect = 7e-30, Method: Compositional matrix adjust.
 Identities = 86/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QNIKDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSPKVRL  121
            +++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL   ++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYREAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

745) GU3_15365 in NC_016745


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (453),  Expect = 7e-30, Method: Compositional matrix adjust.
 Identities = 111/273 (41%), Positives = 182/273 (67%), Gaps = 3/273 (1%)

Query  12   FNVTAALTEDLGGSLDPKQDITAMLLPEDQQVTAHLITRESGVFCGRDFAEETFTQLGGR  71
            F++  +L   L   +++ +  T  ++ ++ Q    L+++E+GV+ G    +  FT +++ 
Sbjct  11   FQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAE  70

Query  72   VQLH--WLVKDGDAITAGQRLLTLTGPARAILTGERTALNFIQTLSAVATETKRYVDKLA  129
            V ++     KDGD +T+G+ +L + G+ R++LT ER ALNF+Q LS++A+ T  YV+ L+
Sbjct  71   VTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG  130

Query  130  GTQCRLLDTRKTLPGLRQALKYAVTCGGGHNHRMGLYDAYLIKENHIFACGGIAQAVAEA  189
            + + +++DTRKT P LR   KYAV  GGG NHR  L DA ++K+NHI A G++ +A+A+A
Sbjct  131  DDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQA  190

Query  190  RR-lqpekpveveveslpeleQALAAGADIIMLDNFSVPDMrtavattagrarLEVSGNV  248
            R      K VEVEVESL+  E+A AAG DIIMLDN S+ ++  A++  AGR+R+E SGN+
Sbjct  191  RAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNI  250

Query  249  TLETIADYAATGVDFVSVGALTKHVHALDLSLR  281
             + TI+ + + ++D+VS G+LT    +LD+S++
Sbjct  251  DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

746) nadC in NC_017956


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (453),  Expect = 7e-30, Method: Compositional matrix adjust.
 Identities = 113/279 (41%), Positives = 183/279 (66%), Gaps = 3/279 (1%)

Query  7    SHLPDILVEPILRAALIEDLGRAGDITSAAVIPagarmaavmaarQPGVMAGGTVAALAF  66
            ++L  + ++  L+AAL ED+ ++ D ++ A++   ++    + A+++GV+AG TV    F
Sbjct  6    TDLTPFQIDDTLKAALREDV-HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVF  64

Query  67   RLLDPGV--ETRIIIPDGAAVVPGDVVMTIEGPARSVLGAERVALNLACRlagiatatag  124
             L+D+ V  +    + DG  + +GD+V+ I G+ RS+L  ERVALN+  +L+GIA+ TA+
Sbjct  65   TLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAA  124

Query  125  lvaaaaPHQARITCTRKTTPGLRLLEKYAVRAGGGANHRFGLDDAVLIKDNhiavaggag  184
             V A + ++ ++  TRKTTP LRL+EKYAVR GGG NHRF L DA+++KDNHIA  G+  
Sbjct  125  YVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  185  iairrarahvghLVKIEVEIDRLDQLDEVLEAGADAILLDNMTPAELAEAVARIGGRAIT  244
             AI +ARA    +  +EVE++ L   +E   AG D I+LDNM+  ++ +A++ I+GR+  
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  245  EASGRITRETVGAVAASGVDLISAGWLTHSAPILDLGLD  283
            E SG I   T++   + ++D +S+G LTHSA  LD+++ 
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

747) Exig_2100 in NC_010556


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (452),  Expect = 8e-30, Method: Compositional matrix adjust.
 Identities = 108/263 (42%), Positives = 170/263 (65%), Gaps = 5/263 (1%)

Query  14   LVEDIGHQDVTSEVCLTGDEIGTGHFMAKEDGIFCGEAVLVELARLLGVE----HETLVR  69
            L ED+  +D +++  +  +  +   + AKE G++ G +V+  +  L++ E    +    +
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  70   DGEPIVQGQVVAKWTGRLQAILTGERVALNLIQRTSGIATLTHQAVR-LVAGNVRIADTR  128
            DG+ +  G++V    G ++++LT ERVALN++Q+ SGIA++T   V  L  + +++ DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  129  KTTPGLRMLEKHAVRVGGGFNHRGRLDDAVMIKDNHITVAGSITAAVRRAKAQVGHTTPI  188
            KTTP LR++EK AVRVGGG+NHR  L DA+M+KDNHI+  GS+  A+ +A+A       +
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  189  evevetgeevkeavaagvDIIMLDNRTPEEIKRFRSWIPKSITVELSGGITLDTLPAYSE  248
            EVEVE+     EA AAGVDIIMLDN + E+I +  + I+    +E SG I + T++ +  
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRG  260

Query  249  CGADYISLGALTHSAPALDISMK  271
             + DY+S G+LTHSA +LD+SMK
Sbjct  261  LAIDYVSSGSLTHSAKSLDFSMK  283

748) HPSNT_06785 in NC_017376


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (452),  Expect = 8e-30, Method: Compositional matrix adjust.
 Identities = 87/210 (42%), Positives = 137/210 (66%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETEEIAAYRDAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DNMS+ + E+  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

749) Thimo_1735 in NC_019940


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  124 bits (452),  Expect = 9e-30, Method: Compositional matrix adjust.
 Identities = 105/251 (42%), Positives = 169/251 (68%), Gaps = 10/251 (3%)

Query  56   RSHVELVAREAAVLCGQAWLETVFRLLDPTVEVTWERV----DGEAIAAGQRVCHLAGPS  111
            ++ V L A+EA+VL G + ++ VF L+D+  EVT +      DG+ +++G+ V ++ G+ 
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDA--EVTFQNPHQFKDGDRLTSGDLVLEIIGSV  98

Query  112  RALLTGERTALNYLQTLSGTATRARRYAESVAGLPVRILDTRKTLPGLRVQQKYAVLCGG  171
            R+LLT ER ALN+LQ LSG A+ +  Y E++++  ++++DTRKT P LR+ +KYAV  GG
Sbjct  99   RSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGG  158

Query  172  CHNHRQGLYDAILIKENHILaagsiaaalaaaqavaPRVP-IEIEVESLAELEQALTAGA  230
              NHR  L DAI++K+NHI A GS+  A+A A+A AP V  +E+EVESLA  E+A +AG 
Sbjct  159  GYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGV  218

Query  231  RHVLLDNFGLADLRRAVALSARQARLEASGGVTLDGIRAIAETGVDDISVGDLTKDVTAI  290
              ++LDN +L ++ +A++L A ++R+E SG + +  I  +   ++D +S G LT    ++
Sbjct  219  DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSL  278

Query  291  DLSMR---FLD  298
            D+SM+   +LD
Sbjct  279  DFSMKGLTYLD  289

750) nadC in NC_009445


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (448),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 112/257 (44%), Positives = 176/257 (69%), Gaps = 2/257 (0%)

Query  25   RAGDITTDAIVPAGqraalqlrarqPGVIAGLDVARCAFQTVSPEVRMETIRG--DGSVV  82
            ++ D +T+AI     +A + L A+++GV+AGL V +  F    +EV  +  +   DG  +
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRL  85

Query  83   AAGDVIATINGPARALLTGERVALNFLCHLsgvasataslvaavKGTRAQIVCTRKTTPG  142
            ++GD++  I G+ R+LLT ERVALNFL HLSG+AS TA+ V A+ + R ++  TRKTTP 
Sbjct  86   TSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPN  145

Query  143  LRALEKYAVRAGGGGNHRFGLDDAVLIKDNhiaiaggiaaaitrakahaghLVKIEVEVD  202
            LR +EKYAVR GGG NHRF L DA+++KDNHIA  G++  AI++A+A A  +  +EVEV+
Sbjct  146  LRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVE  205

Query  203  NLAQLEQALKLGVDAVLLDNMTPPELERAVGMARGKAITEASGRITVDTAPAIAAAGVDL  262
            +LA  E+A   GVD ++LDNM+  ++E+A+ +  G++  E SG I + T + + + ++D 
Sbjct  206  SLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDY  265

Query  263  ISVGWITHSSAALDIGL  279
            +S G +THS+ +LD+++
Sbjct  266  VSSGSLTHSAKSLDFSM  282

751) HPLT_06800 in NC_017362


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (450),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 87/211 (42%), Positives = 136/211 (65%), Gaps = 3/211 (1%)

Query  61   TQTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
             + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLAHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +A+AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESINAYAKSGVDAISVGALIHQATFIDMHMK  271
             +I+ +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

752) nadC in NC_020508


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (450),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 86/207 (42%), Positives = 134/207 (65%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGGFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDT  124
            KD +R+ + D ++EI G+   LL  ER  LN+LQH SGIA++T+ +VEAL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDTHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

753) HPPC18_06775 in NC_017742


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (450),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 86/207 (42%), Positives = 134/207 (65%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

754) K750_01635 in NC_021217


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (448),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 86/211 (41%), Positives = 136/211 (65%), Gaps = 3/211 (1%)

Query  61   TQTIKDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
             + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESINAYAKSGVDAISVGALIHQATFIDMHMK  271
             +I+ +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

755) Mspyr1_29600 in NC_014814


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (448),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 98/241 (41%), Positives = 160/241 (67%), Gaps = 4/241 (1%)

Query  45   MVPREPGVLAGGELAVMVLDEVIGSGAYSVEQLIPDGTRMDAGTVALAVKAPTRGLLTAE  104
            + ++E+GVLAG  +   V+    +  ++   + + DG R+ +G + L + ++ R+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  105  RTMLNLVCHLSGIATATAAWVDAVSGTGAQIRDTRKTLPGLRALQKYAVRVGGGVNHRMG  164
            R  LN++ HLSGIA+ TAA V+A+++   ++ DTRKT P LR ++KYAVRVGGG NHR  
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  165  LGDAALIKDNHVAAAGSvvaalrevravaPDLP-CEVEVDSLEQldevlaegvelvllDN  223
            L+DA ++KDNH+AA GSV  A+ + RA AP +   EVEV+SL   +E  A GV++++LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  224  FPVWQTQIAVQRRDARSPQTKLESSGGLALENAAEYAGTGVDYLAVGALTHSVRVLDLGL  283
             ++ Q + A+    +RS   ++E SG + +   + + G ++DY++ G+LTHS + LD+++
Sbjct  226  MSLEQIEQAITLIAGRS---RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

Query  284  D  284
             
Sbjct  283  K  283

756) SiL_1089 in NC_021058


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  123 bits (451),  Expect = 8e-30, Method: Compositional matrix adjust.
 Identities = 98/236 (42%), Positives = 147/236 (63%), Gaps = 7/236 (2%)

Query  22   KDSGILAG-NRFVIPFLNY---LGFSNINGEKDGSEVNKGDVVL-LFEGNADVLTVERLI  76
            K++G+LAG   F   F  +   + F N +  KDG  +  GD+VL ++ +   +LT ER+ 
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  77   LNFLGKLSGIATITNLMVKRAREVNPNVRISGTRKTTPGFRLFEKYAIEVGGGDPHRYNL  136
            LNFL  LSGIA++T   V    +    +++ +TRKTTP +RLFEKYA+ VGGG  HR+NL
Sbjct  109  LNFLQHLSGIASMTAAYVEALGD--DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNL  166

Query  137  SDAVLIKDNHIALYGNIEELIKRVKSSVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNM  196
            SDA+++KDNHIA  G+++  I + ++  +F K++EVEV S   A  A  AG D I+LDNM
Sbjct  167  SDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNM  226

Query  197  KPYEILPIVNELKGKVILEASGGITPDNVVDYARTGVDIISSGYTTHSSRSLDFSL  252
               +I   +  + G+  +E SG I    +  +   ++D +SSG  THS++SLDFS+
Sbjct  227  SLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

757) Deipe_2574 in NC_019793


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (446),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 100/225 (45%), Positives = 153/225 (68%), Gaps = 6/225 (2%)

Query  53   QAFTLLDPSVRV--CWHVTEGQPLPPGCLIGEVSGPMRALLGAERVALNLLQRMSGIATH  110
            + FTL+D+ V      +  +G+ L +G L+ E+ G++R+LL  ERVALN+LQ++SGIA+ 
Sbjct  62   RVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASM  121

Query  111  TYAHAQALQGTRARLLDTRKTTPLWRDLEKQATRHGGASNHRWGLDDGILIKDNHIeavg  170
            T A  +AL + R +++DTRKTTP  R +EK A R GG+ NHR  L D+I++KDNHI AVG
Sbjct  122  TAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVG  181

Query  171  svaeavrra-rasaYLLKVECEVETLDELREALTAGADRVLLDNMMDTVLAQAVALRDEL  229
            SV  A+ +A   ++++  VE EVE+L    EA +AG D ++LDNM    + QA++L   +
Sbjct  182  SVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL---I  238

Query  230  APHVTLEASGNMTLERLPRVAQSGVDYISVGALTHSAPSLDISLN  274
            A +  +E SGN+ +  ++R    ++DY+S G+LTHSA SLD+S++
Sbjct  239  AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

758) nadC in NC_011498


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (446),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 87/207 (43%), Positives = 134/207 (65%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDAHYPFVLLEASGNISLETIN  244
            +E+E ES+  A +A  AG DI+M DNMS+ +  +  +   ++     +E SGNI + TI+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

759) nadC in NC_011294


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (445),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 100/243 (42%), Positives = 159/243 (66%), Gaps = 2/243 (0%)

Query  6    QAHATVITREDGVFCGKRWVEEVFIQLAGD-DVRLTWHVDDGDAIHANQTVFELNGPARV  64
            QA  +++++E GV+ G    + VF  + ++   +   +  DGD + + + V+E+ G+ R 
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  65   LLTGERTALNFVQTLSGVASEVRRYVGLLAGTQTQLLDTRKTLPGLRTALKYAVLCGGGA  124
            LLT ER ALNF+Q LSG+AS    YV  L++ + +++DTRKT P LR   KYAV  GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  125  NHRLGLTDAFLIKENHIIASGSVRQAVEKA-FWLHpdvpvevevenldelddALKAGADI  183
            NHR+ L+DA+++K+NHI A GSV++A+ +A         VEVEVE+L   ++A  AG DI
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  184  IMLDNFNTDQMREAVKRVNGQARLEVSGNVTAETLREFAETGVDFISVGALTKHVRALDL  243
            IMLDN + +Q+ +A+  + G++R+E SGN+   T+  F   ++D++S G+LT   ++LD+
Sbjct  221  IMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDF  280

Query  244  SMR  246
            SM+
Sbjct  281  SMK  283

760) nadC in NC_011274


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (445),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 100/243 (42%), Positives = 159/243 (66%), Gaps = 2/243 (0%)

Query  6    QAHATVITREDGVFCGKRWVEEVFIQLAGD-DVRLTWHVDDGDAIHANQTVFELNGPARV  64
            QA  +++++E GV+ G    + VF  + ++   +   +  DGD + + + V+E+ G+ R 
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  65   LLTGERTALNFVQTLSGVASEVRRYVGLLAGTQTQLLDTRKTLPGLRTALKYAVLCGGGA  124
            LLT ER ALNF+Q LSG+AS    YV  L++ + +++DTRKT P LR   KYAV  GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  125  NHRLGLTDAFLIKENHIIASGSVRQAVEKA-FWLHpdvpvevevenldelddALKAGADI  183
            NHR+ L+DA+++K+NHI A GSV++A+ +A         VEVEVE+L   ++A  AG DI
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  184  IMLDNFNTDQMREAVKRVNGQARLEVSGNVTAETLREFAETGVDFISVGALTKHVRALDL  243
            IMLDN + +Q+ +A+  + G++R+E SGN+   T+  F   ++D++S G+LT   ++LD+
Sbjct  221  IMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDF  280

Query  244  SMR  246
            SM+
Sbjct  281  SMK  283

761) STMMW_01511 in NC_016854


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (445),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 100/243 (42%), Positives = 159/243 (66%), Gaps = 2/243 (0%)

Query  6    QAHATVITREDGVFCGKRWVEEVFIQLAGD-DVRLTWHVDDGDAIHANQTVFELNGPARV  64
            QA  +++++E GV+ G    + VF  + ++   +   +  DGD + + + V+E+ G+ R 
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  65   LLTGERTALNFVQTLSGVASEVRRYVGLLAGTQTQLLDTRKTLPGLRTALKYAVLCGGGA  124
            LLT ER ALNF+Q LSG+AS    YV  L++ + +++DTRKT P LR   KYAV  GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  125  NHRLGLTDAFLIKENHIIASGSVRQAVEKA-FWLHpdvpvevevenldelddALKAGADI  183
            NHR+ L+DA+++K+NHI A GSV++A+ +A         VEVEVE+L   ++A  AG DI
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  184  IMLDNFNTDQMREAVKRVNGQARLEVSGNVTAETLREFAETGVDFISVGALTKHVRALDL  243
            IMLDN + +Q+ +A+  + G++R+E SGN+   T+  F   ++D++S G+LT   ++LD+
Sbjct  221  IMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDF  280

Query  244  SMR  246
            SM+
Sbjct  281  SMK  283

762) nadC in NC_016810


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (445),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 100/243 (42%), Positives = 159/243 (66%), Gaps = 2/243 (0%)

Query  6    QAHATVITREDGVFCGKRWVEEVFIQLAGD-DVRLTWHVDDGDAIHANQTVFELNGPARV  64
            QA  +++++E GV+ G    + VF  + ++   +   +  DGD + + + V+E+ G+ R 
Sbjct  41   QAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS  100

Query  65   LLTGERTALNFVQTLSGVASEVRRYVGLLAGTQTQLLDTRKTLPGLRTALKYAVLCGGGA  124
            LLT ER ALNF+Q LSG+AS    YV  L++ + +++DTRKT P LR   KYAV  GGG 
Sbjct  101  LLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY  160

Query  125  NHRLGLTDAFLIKENHIIASGSVRQAVEKA-FWLHpdvpvevevenldelddALKAGADI  183
            NHR+ L+DA+++K+NHI A GSV++A+ +A         VEVEVE+L   ++A  AG DI
Sbjct  161  NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDI  220

Query  184  IMLDNFNTDQMREAVKRVNGQARLEVSGNVTAETLREFAETGVDFISVGALTKHVRALDL  243
            IMLDN + +Q+ +A+  + G++R+E SGN+   T+  F   ++D++S G+LT   ++LD+
Sbjct  221  IMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDF  280

Query  244  SMR  246
            SM+
Sbjct  281  SMK  283

763) Dde_1831 in NC_007519


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (447),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 109/270 (41%), Positives = 168/270 (63%), Gaps = 14/270 (5%)

Query  35   DGPDLTSNAVFAPSHQLAAQIIAKEDSLVCGLAYIPYIMDRVIA-CDPQPQGWDDYTVDT  93
            ++ D ++NA+F    Q    ++AKE +++ GL+    + +RV++  D++      +    
Sbjct  26   HSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLT----VFQRVFTLFDAEV----TFQNPH  77

Query  94   PYADGAHVTAGTTVVrlrasarrllkaerIILNFMTHLSGIANLTARYVDALSGTGTRLL  153
             + DG ++T+G  V+ + +S R LL  ER+ LNF+ HLSGIA++TA YV+AL++   +++
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  154  DTRKTLPGLRYPEKYAVVIGGGLNHRRNLQEMLMLKDNHIDLAGSITAAVQRLRDTYSP-  212
            DTRKT P LR  EKYAV +GGG NHR NL + +MLKDNHI   GS+  A+ + R +Y+P 
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR-AYAPF  196

Query  213  CPPVEVECRTPDDVCEAVACNVDRIMLDNMDADGLAAALPLIPDHIETEASGGVTLETIR  272
               VEVE  +     EA A  VD IMLDNM  + +  A+ LI+++   E SG + + TI 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI-  255

Query  273  VLAQASSRRLDFISVGRLTHSAPSADFSMR  302
              ++  +  +D++S G LTHSA S DFSM+
Sbjct  256  --SRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

764) HPSJM_06800 in NC_014560


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (446),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 85/211 (41%), Positives = 138/211 (66%), Gaps = 3/211 (1%)

Query  61   TQTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR  120
             + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKNFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  +++ +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMSAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A +AG DI+M DN+S+ +  +  +   ++     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESINAYAKSGVDAISVGALIHQATFIDMHMK  271
             +I+ +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

765) Mflv_3617 in NC_009338


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (447),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 98/241 (41%), Positives = 160/241 (67%), Gaps = 4/241 (1%)

Query  47   MVPREPGVLAGGELAVMVLDEVIGSGAYSVEQLIPDGTRMDAGTVALAVKAPTRGLLTAE  106
            + ++E+GVLAG  +   V+    +  ++   + + DG R+ +G + L + ++ R+LLT E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  107  RTMLNLVCHLSGIATATAAWVDAVSGTGAQIRDTRKTLPGLRALQKYAVRVGGGVNHRMG  166
            R  LN++ HLSGIA+ TAA V+A+++   ++ DTRKT P LR ++KYAVRVGGG NHR  
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  167  LGDAALIKDNHVAAAGSvvaalrevraaaPDLP-CEVEVDSLEQldevlaegvelvllDN  225
            L+DA ++KDNH+AA GSV  A+ + RA AP +   EVEV+SL   +E  A GV++++LDN
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  226  FPVWQTQIAVQRRDARSPQTKLESSGGLALENAAEYAGTGVDYLAVGALTHSVRVLDLGL  285
             ++ Q + A+    +RS   ++E SG + +   + + G ++DY++ G+LTHS + LD+++
Sbjct  226  MSLEQIEQAITLIAGRS---RIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

Query  286  D  286
             
Sbjct  283  K  283

766) OCC_06601 in NC_022084


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (446),  Expect = 2e-29, Method: Compositional matrix adjust.
 Identities = 108/269 (41%), Positives = 177/269 (66%), Gaps = 15/269 (5%)

Query  11   LEEDSPFGDITSDAIIPKTLNTKAVIIAKQSGVVAGLEEAKMLFEYFGV----KAKQRAQ  66
            L ED    D +++AI+    ++K  ++AK++GV+AGL   + +F  F+     +  ++ +
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  67   DGQKVEKGQILMELEGNARKILLVERTALNIIGRMSGVATQTRKLVEKIKGINPKIRVAG  126
            DG+++  G++++E+ G+ R +L  ER ALN++ ++SG+A+ T   VE +   + +I+V +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG--DDRIKVFD  138

Query  127  TRKSL--LRDLDKKAIILGGGEPHRFSLSDAILIKDNHLALV-SLEEAIKKARAFSVY-K  182
            TRK+   LR ++K A+ +GGG  HRF+LSDAI++KDNH+A V S++ AI +ARA++ + K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  183  vveveveSLEDALKAARAGADVIMLDNMTPEQIEEILKALKREELREKVKIEVSGGISEE  242
            +VEVEVESL  A  AA AG D+IMLDNM+ EQIE+ +  +       + +IE SG I   
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIA-----GRSRIECSGNIDMT  253

Query  243  NIESYAKLDVDIISLGALTHSVKNFDVSL  271
             I  +  L +D +S G+LTHS K++D S+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

767) M446_4589 in NC_010511


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (446),  Expect = 3e-29, Method: Compositional matrix adjust.
 Identities = 93/216 (44%), Positives = 152/216 (71%), Gaps = 5/216 (2%)

Query  73   EVAVSIARP----DGSQVAPGETVMHLSGPARAILSAERVALNLLCRLSGVATATASLVE  128
            +  V++  P    DG ++++G+ V+++ G+ R++L+ ERVALN+L +LSG+A+ TA+ VE
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  129  AARAHGPARIVCTRKTTPGLRALEKRAVRAGGGSNHRFGLDDAVLIKDNHVAVAGGVGPA  188
            A  +++  ++  TRKTTP LR +EK AVR GGG NHRF L DA+++KDNH+A  G+V  A
Sbjct  128  AL-GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKA  186

Query  189  IRRARAGTGHLVKIEVEVdtlaqleealaegadavlldNMAPDALRRAVAMIDGRAISEA  248
            I +ARA +  +  +EVEV++LA  EEA A G D ++LDNM+ + + +A+++I GR+  E 
Sbjct  187  IAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  249  SGRITRETVGAVAASGVDLISAGWITHSAAIIDLGL  284
            SG I   T++   + ++D +S+G +THSA  +D+++
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

768) nadC in NC_008229


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  122 bits (445),  Expect = 3e-29, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 134/210 (64%), Gaps = 3/210 (1%)

Query  62   QNIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            +++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLTSFLAHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  +   +A+AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECGSFEEVKNAMNAGADIVMCDNMSVEETKEIAAYRDMHYPFVLLEASGNISLE  241
               +E+E  S+    +A  AG DI+M DNMS+E+  +  +    +     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SVNAYAKSGVDAISVGALIHQATFIDMHMK  271
            +++ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

769) nadC in NC_002607


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (443),  Expect = 3e-29, Method: Compositional matrix adjust.
 Identities = 107/263 (41%), Positives = 161/263 (62%), Gaps = 11/263 (4%)

Query  12   LREDLGHHDVTNDV----PGETTGRLVAKQAGVAAGLDAAVRVFEYLGCEADAPAA----  63
            LRED+  +D + +      G++   L AK+AGV AGL    RVF  ++ E     +    
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  64   AGDRIDAGDTVLRVSGAAQSVLRAERVAVNVAGHASGvatktrravaaareasddvaiaG  123
             GDR+ +GD VL + G+ +S+L  ERVA+N   H SG+A+ T   V A  +    V   +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF--D  138

Query  124  TRKTTPGLRGVEKRAVVAGGGDTHRLDLSHMVMVKDNHVAELG-LEGAIERFRAAKSFAT  182
            TRKTTP LR  EK AV  GGG  HR++LS+ +M+KDNH+A +G ++ AI + RA  +F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  183  KLDVEVETPEDAPRAADAGADIVLLDNMTPAETERAVDLLDGAALAEASGGITVDDVPAY  242
             ++VEVE+   A  AA AG DI++LDNM+  + E+A+ L+ G +  E SG I +  ++ +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  243  AATGVDVISMGALTHSAPTLDLS  265
             + ++D +S G+LTHSA +LD+S
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFS  281

770) nadC in NC_010364


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (443),  Expect = 3e-29, Method: Compositional matrix adjust.
 Identities = 107/263 (41%), Positives = 161/263 (62%), Gaps = 11/263 (4%)

Query  12   LREDLGHHDVTNDV----PGETTGRLVAKQAGVAAGLDAAVRVFEYLGCEADAPAA----  63
            LRED+  +D + +      G++   L AK+AGV AGL    RVF  ++ E     +    
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  64   AGDRIDAGDTVLRVSGAAQSVLRAERVAVNVAGHASGvatktrravaaareasddvaiaG  123
             GDR+ +GD VL + G+ +S+L  ERVA+N   H SG+A+ T   V A  +    V   +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF--D  138

Query  124  TRKTTPGLRGVEKRAVVAGGGDTHRLDLSHMVMVKDNHVAELG-LEGAIERFRAAKSFAT  182
            TRKTTP LR  EK AV  GGG  HR++LS+ +M+KDNH+A +G ++ AI + RA  +F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  183  KLDVEVETPEDAPRAADAGADIVLLDNMTPAETERAVDLLDGAALAEASGGITVDDVPAY  242
             ++VEVE+   A  AA AG DI++LDNM+  + E+A+ L+ G +  E SG I +  ++ +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  243  AATGVDVISMGALTHSAPTLDLS  265
             + ++D +S G+LTHSA +LD+S
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFS  281

771) HPB14_06485 in NC_017733


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (443),  Expect = 4e-29, Method: Compositional matrix adjust.
 Identities = 87/210 (42%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLAHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +A+AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMSAGADIVMCDNMSVLETKEIAAYREVHYPFVLLEASGNISLE  241
               +E+E ES+  A +A +AG DI+M DNMS+ +  +  +    +     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

772) HPPC_06665 in NC_014555


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (443),  Expect = 4e-29, Method: Compositional matrix adjust.
 Identities = 86/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QNIKDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSPKVRL  121
            +++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL   ++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLAHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +A+AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DN+S+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

773) Oweho_1383 in NC_016599


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (443),  Expect = 4e-29, Method: Compositional matrix adjust.
 Identities = 109/272 (41%), Positives = 177/272 (66%), Gaps = 6/272 (2%)

Query  11   IDDAIAEDIGPGDHSSNCSIPATAEGKMYLLVKEEGIIAGIDVAKRVFEKVDPAIKMEI-  69
            +  A+ ED+ + D S+N  +   +++K+ L+ KE G++AG+ V +RVF   D+ +  +  
Sbjct  17   LKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP  76

Query  70   -LMRDGDAVKLGDIAFRLQGPerallrserlalNIMQRMSGIATRTHHIVKLIEGTPTKL  128
               +DGD +  GD+ + + G+ R+LL  ER+ALN++Q++SGIA+ T   V  + +   K+
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  129  LDTRKTTPNMRALEKYAVTVGGGYNHRMGLYDMIMLKDNHVDFAGGIINAIDKAHEYIKE  188
            +DTRKTTPN+R +EKYAV VGGGYNHR  L D IMLKDNH+   G++ +AI +A+ Y   
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAY---  193

Query  189  NGLDIGIEVETRNLEELQQVIDKGGVQRVMFDNYSIEDTIKALNMVGGKFetessggite  248
              +   +EVE  +L    +    +GV+ +M+DN S+E+  +A+ +++G+   E SG I  
Sbjct  194  APFVKMVEVEVESLAA-AEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDM  252

Query  249  ttiRSYAETGVDFISVGALTHSVKSLDLSLKA  280
            TTI  +   ++D++S G+LTHS KSLD+S+K+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMKG  284

774) F504_2408 in NC_020799


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (442),  Expect = 5e-29, Method: Compositional matrix adjust.
 Identities = 107/247 (44%), Positives = 169/247 (69%), Gaps = 5/247 (2%)

Query  51   DRHACARV--IVREAAVLCGAPWFDACMQAVDPALRVTWLQH--EGDRMAPDSVVCEIEG  106
            D+H+ A+V  + +EA+VL G   F+      D+ +     ++  +GDR++++ +V EI G
Sbjct  37   DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIG  96

Query  107  PARSLLTAERASLNFLQLLSGVATATSRYAEAIAGTRARVLDTRKTLPGLRLAQKYAVRI  166
            + RSLLT ER +LNFLQ LSG+A+ T+ Y EA+++ R +V+DTRKT P LRL +KYAVR+
Sbjct  97   SVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRV  156

Query  167  GGGENQRLALYDGILIKENHIaaaggvtaalraaqaldagVP-IQvevetlaeleealaa  225
            GGG N+R+ L D+I++K+NHIAA G+V  A+  A+A  + V  ++VEVE+LA  EEA AA
Sbjct  157  GGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAA  216

Query  226  gatSVLLDNFDEPAMHEAVRVTAGRALLEVSGGVSMATIRAFAQTGVDRISVGALTKDVR  285
            G   ++LDN     +++A+ + AGR+ +E SG + M+TI  F   ++D +S G+LT   +
Sbjct  217  GVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK  276

Query  286  ATDYSLR  292
            + D+S++
Sbjct  277  SLDFSMK  283

775) Mjls_3083 in NC_009077


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (442),  Expect = 5e-29, Method: Compositional matrix adjust.
 Identities = 88/213 (42%), Positives = 142/213 (67%), Gaps = 4/213 (1%)

Query  75   YRVVDRVEDGTRLEPGAALLTLDAPTRGLLTAERTMLNLVSHLSGIATSTAIWVDAVAGT  134
            ++  ++  DG RL +G  +L + ++ R+LLT ER  LN++ HLSGIA+ TA  V+A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  135  NAKIRDTRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvvaalrav-r  193
              K+ DTRKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+     
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  194  aaapglpCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRDSRSPATKLESSGG  253
             A+     EVEV+SL   +E  A ++++++LDN ++ Q + A+    +RS   ++E SG 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGN  249

Query  254  LSLETAAEYAGTGVDYLAVGALTHSVRVLDIGL  286
            + + T + + G ++DY++ G+LTHS + LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

776) Ssol_1973 in NC_017274


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (442),  Expect = 5e-29, Method: Compositional matrix adjust.
 Identities = 106/264 (41%), Positives = 164/264 (63%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIRARGIVRCKDSGILAG----NRFIVPFLKYLGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG    +R +  F   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGREVKKGDIVLNFEGDA-DILTVERLILNFLGKLSGIATITNLMVKKAKEVNPYVRIAG  126
            DG  +  GD+VL++ G    +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR--IKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHITLYGNLEELIKRVKFSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHI+  G+++  I + +   +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAFKAGADVILLDNMKPYEILPIVNELKSKVLLEASGGITPDNVIDY  246
            ++EVEV S   A  A  AG D+I+LDNM   +I   +  + ++  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  AKTGVDVISSGYITHSYRSLDFSL  270
               ++D +SSG +THS +SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

777) SSO0996 in NC_002754


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (442),  Expect = 5e-29, Method: Compositional matrix adjust.
 Identities = 106/264 (41%), Positives = 164/264 (63%), Gaps = 9/264 (3%)

Query  14   LEEDVMPEDITTK--FLEGIRARGIVRCKDSGILAG----NRFIVPFLKYLGFSNINGEK  67
            L EDV +ED +T+  F +  +A+  +  K++G+LAG    +R +  F   + F N +  K
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGREVKKGDIVLNFEGDA-DILTVERLILNFLGKLSGIATITNLMVKKAKEVNPYVRIAG  126
            DG  +  GD+VL++ G    +LT ER+ LNFL  LSGIA++T   V    +    +++ +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR--IKVFD  138

Query  127  TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHITLYGNLEELIKRVKFSVSFTK  186
            TRKTTP +RLFEKYA+ VGGG  HR+NLSDA+++KDNHI+  G+++  I + +   +F K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  187  IIEVEVSSYEDAIRAFKAGADVILLDNMKPYEILPIVNELKSKVLLEASGGITPDNVIDY  246
            ++EVEV S   A  A  AG D+I+LDNM   +I   +  + ++  +E SG I    +  +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  247  AKTGVDVISSGYITHSYRSLDFSL  270
               ++D +SSG +THS +SLDFS+
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

778) Mkms_3126 in NC_008705


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (441),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 88/213 (42%), Positives = 142/213 (67%), Gaps = 4/213 (1%)

Query  75   YRVVDRVEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGIATSTAMWVDAVAGT  134
            ++  ++  DG RL +G  +L + ++ R+LLT ER  LN++ HLSGIA+ TA  V+A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  135  NAKIRDTRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvvaalrav-r  193
              K+ DTRKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+     
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  194  aaapglpCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRDSRSPATKLESSGG  253
             A+     EVEV+SL   +E  A ++++++LDN ++ Q + A+    +RS   ++E SG 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGN  249

Query  254  LSLETAAEYAGTGVDYLAVGALTHSVRVLDIGL  286
            + + T + + G ++DY++ G+LTHS + LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

779) Mmcs_3066 in NC_008146


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (441),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 88/213 (42%), Positives = 142/213 (67%), Gaps = 4/213 (1%)

Query  75   YRVVDRVEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGIATSTAMWVDAVAGT  134
            ++  ++  DG RL +G  +L + ++ R+LLT ER  LN++ HLSGIA+ TA  V+A+++ 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  135  NAKIRDTRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvvaalrav-r  193
              K+ DTRKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+     
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  194  aaapglpCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRDSRSPATKLESSGG  253
             A+     EVEV+SL   +E  A ++++++LDN ++ Q + A+    +RS   ++E SG 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS---RIECSGN  249

Query  254  LSLETAAEYAGTGVDYLAVGALTHSVRVLDIGL  286
            + + T + + G ++DY++ G+LTHS + LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

780) C694_06995 in NC_018939


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (441),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DN+S+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

781) HP1355 in NC_000915


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (441),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DN+S+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

782) C695_07005 in NC_018937


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (441),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DN+S+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

783) C730_07005 in NC_018938


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  121 bits (441),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 136/210 (65%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DN+S+ +  +  +   ++     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

784) HPELS_07030 in NC_017063


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  120 bits (440),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 85/207 (42%), Positives = 133/207 (65%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTTK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDTHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DN+S+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

785) HPG27_1303 in NC_011333


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  120 bits (440),  Expect = 6e-29, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 135/210 (65%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALNSHKVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  +++++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIASYRDTHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DN+S+ +  +  +    +     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

786) HPSA_07780 in NC_017361


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  120 bits (439),  Expect = 8e-29, Method: Compositional matrix adjust.
 Identities = 86/209 (42%), Positives = 134/209 (65%), Gaps = 3/209 (1%)

Query  63   NIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHEVRLL  122
            ++KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  + ++++
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  123  DTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFT  182
            DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF 
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  183  AKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYREVHYPFVLLEASGNISLES  242
              +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + +
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTT  254

Query  243  INAYAKSGVDAISVGALIHQATFIDMHMK  271
            I+ +   ++D +S G+L H A  +D  MK
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

787) Hbor_10050 in NC_014729


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (436),  Expect = 1e-28, Method: Compositional matrix adjust.
 Identities = 107/263 (41%), Positives = 157/263 (60%), Gaps = 11/263 (4%)

Query  11   LREDVGHRDVTNDV----PGETTGRLVAKESGVVAGLDAAVTVFDYLGVAAT----PAVD  62
            LREDV   D + +      G++   L AKE+GV+AGL     VF  ++   T        
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  63   DGASVEPGAVVLETSGPARETLRGERVAVNVVGHASGvatrtrraveaaheaNPDARVAA  122
            DG  + +G +VLE  G+ R  L  ERVA+N + H SG+A+ T   VEA    +   +V  
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG--DDRIKVFD  138

Query  123  TRKTTPGLRGVEKRAVVAGGGDTHRLTLSGMVMVKDNHVAEMG-LEGAIERFRERKSFAT  181
            TRKTTP LR  EK AV  GGG  HR+ LS+ +M+KDNH+A +G ++ AI + R   +F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  182  KLEVEVESPEMGARAADAGTDIVLFDNLSPDEVRDGVERLPDSVLAEASGGITLDTVADY  241
             +EVEVES   +  AA AG DI+++DN+S +++ +++  +++    E SG I + T++ +
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  242  AATGVDVVSMGSLTHSAPSLDFS  264
             + ++D VS GSLTHSA SLDFS
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFS  281

788) Adeh_2389 in NC_007760


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (435),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 111/253 (44%), Positives = 178/253 (71%), Gaps = 6/253 (2%)

Query  26   TSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFERLGASCTFdradgara----argEL  81
            +++A +D  + +   ++AKE  VLAG +V  RVF  ++A  TF+ ++  +     + G+L
Sbjct  31   STNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDL  90

Query  82   VGTARGTVRALLAAERTALNFLQRLSGVATATRRCADALAAGGGRTRLLDTRKTTPGWRM  141
            V    G+VR+LL+ ER ALNFLQ+LSG+A+ T    +AL  G++R +++DTRKTTP  R+
Sbjct  91   VLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRL  148

Query  142  LEKAAVRAGGGKNHRFSLGDGVLIKDNHvaacggvaeavrrarasagaMLRVEVEVEDLP  201
            +EK AVR GGG NHRF+L+D++++KDNH+AA G+V  A+ +ARA A  +  VEVEVE L+
Sbjct  149  FEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLA  208

Query  202  GLDEAIAAGADLVLLDNmddaamaeavrraagrvlleaSGNMTLERLPRVAATGVDFVSM  261
            + +EA AAG D+++LDNM    + +A+   AGR  +E SGN+ +  ++R  + ++D+VS 
Sbjct  209  AAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSS  268

Query  262  GAVTHSARAVDLA  274
            G++THSA+++D++
Sbjct  269  GSLTHSAKSLDFS  281

789) MTH1832 in NC_000916


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (433),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 91/216 (43%), Positives = 138/216 (64%), Gaps = 11/216 (5%)

Query  65   DGDPLSGGERVLTLEGDAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEG-IRIA  123
            DGD L++G+ VL + G    +L  ER  LN++  +SGIA++T + ++   A+ ++ I++ 
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE---ALGDDRIKVF  137

Query  124  ATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKDNHIAIVGNIEDAVRRVRDHVSFT  183
             TRKTTP L+ FEK AVR+GGG  HRF L D  M+KDNHIA VG+++ A+ + R   +F 
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  184  KKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGGIKP  243
            K VEVEVES   A  AA AG DI++LDNMS E I +++  +  R+ R    +E SG I  
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRS-R----IECSGNIDM  252

Query  244  DNIELYASTGVEVISMGFITASAHPVDLSLEIRGLK  279
              I  + + +++ +S G +T SA ++D+S+  +GL 
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM--KGLT  286

790) nadC in NC_017368


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (434),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 86/207 (42%), Positives = 132/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHKVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAVSVGALIHQATFIDMHMK  271
             +   ++D VS G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

791) K751_07525 in NC_021218


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (433),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 86/207 (42%), Positives = 132/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSILLKVERTLLNLLQHSSGIATLTSRFVEALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIASYRDVHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

792) nadC in NC_018876


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (436),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 101/245 (42%), Positives = 153/245 (63%), Gaps = 15/245 (6%)

Query  52   IFTKEDCVMAGVDVARSFFDYLGISAVVTCV----DGDRIAGGSTIFSLSGSSVSILRAE  107
            +F+KE  V+AG+ V +  F  ++            DGDR+++G  ++ + GS  S+L  E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  108  RIVLNFLGHLCGIATLTRRCVDNVKRISNARVAC--TRKTTPGLRKYEKLAVIAGGGDPH  165
            R+ LNFL HL GIA++T   V+    +++ R+    TRKTTP LR +EK AV  GGG  H
Sbjct  106  RVALNFLQHLSGIASMTAAYVEA---LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNH  162

Query  166  RFNLSDAVMIKDNHVKMMG-IEAAIMSARKNASFTQKIEVEVESaddalqaaalgadIIM  224
            RFNLSDA+M+KDNH+  +G ++ AI  AR  A+F + +EVEVES   A +AAA G DIIM
Sbjct  163  RFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIM  222

Query  225  LDNMDPHQVADTMASLKRAVIPRHIIIEVSGGIGPDNIEAYARTGVHVISMGSLIHQARW  284
            LDNM  +Q+ +++     ++I+ +  IE SG I+   I  +   +++ +S GSL H A+ 
Sbjct  223  LDNMSLEQIEQAI-----TLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKS  277

Query  285  IDISL  289
            +D+S+
Sbjct  278  LDFSM  282

793) nadC in NC_017926


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  119 bits (433),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 84/207 (41%), Positives = 131/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHKVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLVHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  + +AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMNVLETKEIAAYRDAHYPFVLLEASGNISLENIN  244
            +E+E ES+  A +A  AG DI+M DNM++ +  +  +   ++     +E SGNI +  I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

794) nadC in NC_012526


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  118 bits (432),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 115/264 (44%), Positives = 179/264 (68%), Gaps = 7/264 (2%)

Query  14   EDIGRGDATTLATIPASQTARAEVLMKESGVLSGLDVAARVFTLMDPRLTVRWSAV--DG  71
            ED+   D +T A +     A+  ++ KE+GVL+GL V  RVFTL D+ +T + +    DG
Sbjct  23   EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDG  82

Query  72   EQRERGPIGV-IEGParsllsaerlalnllQRLSGVATQTRRHVDALGSGHTQLLDTRKT  130
            ++   G + + I G+ RSLL+ ER+ALN+LQ+LSG+A+ T   V+ALG ++ +++DTRKT
Sbjct  83   DRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKT  142

Query  131  TPLWRDLEKQAVRHGGGLNHRAGLDDGILIKDNHVAAAGGVTEAICRARTHA-YLLKVEC  189
            TP  R +EK AVR GGG NHR  L D+I++KDNH+AA G+V  AI +AR+ A ++  VE 
Sbjct  143  TPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEV  202

Query  190  EVSdlaglrealragadrVLLDNMNDDLLAEAVAVRNELAPHVTLEASGNMTLERLPKVA  249
            EV  LA+  EA  AG D ++LDNM+ + + +A+++   +A +  +E SGN+ +  +++  
Sbjct  203  EVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL---IAGRSRIECSGNIDMTTISRFR  259

Query  250  TSGVDYVSVGALTHSAPALDISLN  273
              ++DYVS G+LTHSA +LD+S++
Sbjct  260  GLAIDYVSSGSLTHSAKSLDFSMK  283

795) nadC in NC_017375


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  118 bits (431),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 87/207 (43%), Positives = 132/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKSKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHEVRLLDT  124
            KD +R+ S D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

796) HCD_04220 in NC_017735


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  118 bits (431),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 85/207 (42%), Positives = 130/207 (63%), Gaps = 3/207 (1%)

Query  65   KDKECFKPKDTLMEIKGDFSMLLKVERTLLNILQHSSGIATLTKRFVEALNSKKVRLLDT  124
            KD + + + D ++EI G    LL  ER  LN+LQH SGIA++T  +VEAL   +++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRSFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLEHAKKSLPFTAK  184
            RKT P LR FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  + +A+   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECETFEEAKNAMSAGADIVMCDNMTTEQTKEIVAYRNTHYPFVLLEASGNISLETIN  244
            +E+E E++  A +A +AG DI+M DNM+ EQ  + ++    +     +E SGNI + TI+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  SYAQSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

797) Natpe_3454 in NC_019962


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  118 bits (431),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 107/265 (41%), Positives = 164/265 (62%), Gaps = 13/265 (4%)

Query  11   LREDVGHHDVTNQV----PGETTGRLVAKESGVAAGLEAATAVFDYLDVTVT----DRLE  62
            LREDV  +D + +      G++   L AKE+GV AGL     VF  +D  VT    +++ 
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  63   DGTEIEPGDELLRVEGAAREVLRGERVAVNLAGHASGIatrtreavtaarteSDDVAIAA  122
            DG  + +GD +L + G+ R +L  ERVA+N+  H SGIA+ T   V A     D + +  
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG--DDRIKVFD  138

Query  123  TRKTTPGLRGVEKRAVVAGGGDTHRLDLSHMVMVKDNHIEEMG-LEGAIAHFDERTSFAT  181
            TRKTTP LR  EK AV  GGG  HR++LS+ +M+KDNHI  +G ++ AIA+    ++F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  182  KIDVEVERVEDAPRAATAGADIVLLDNMTPDRTRDAVAELADYDGVLAEASGGIAVADVP  241
             ++VEVE +  A  AA+AG DI++LDNM+ ++  +A++ +A+   +  E SG I ++ ++
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI--ECSGNIDMTTIS  256

Query  242  DYAATGVDVISMGSLTHSAPSLDLS  266
             + + ++D +S GSLTHSA SLD+S
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFS  281

798) Svir_10850 in NC_013159


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  118 bits (430),  Expect = 4e-28, Method: Compositional matrix adjust.
 Identities = 99/228 (44%), Positives = 150/228 (66%), Gaps = 8/228 (3%)

Query  63   TVFDTVL----AGDGYEVVSARADGSFLEAGEPALVVRGPVRGLLTAERTALNLLCHLSg  118
            TVF+ V+    A   ++      DG  L +G+  L + G+VR+LLT ER ALN+L HLSG
Sbjct  58   TVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSG  117

Query  119  vatvtaawvravagtgCAIRDSRKTLPGLRVLEKYAVRCGGGVNHRMGLGDAVLIKDNHV  178
            +A++TAA V A+++    + D+RKT P LR++EKYAVR GGG NHR  L+DA+++KDNH+
Sbjct  118  IASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHI  177

Query  179  VAAGSVTEALRLAREKAAGLP-CEVEVDDLDQLAETLHAGADEVLLDNFSPEDCERAVRL  237
             A GSV  A+  AR  A+ +   EVEV+ L    E+  AG D ++LDN S E+ E+A+ L
Sbjct  178  AAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL  237

Query  238  RDELSPKTRLEASGGLKLDDARRYAETGVDYLAVGALTHSAPALDIGM  285
               ++ ++R+E SG + +    R+   ++DY++ G+LTHSA +LD++M
Sbjct  238  ---IAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

799) HPSH169_06740 in NC_017740


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (427),  Expect = 6e-28, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 133/210 (64%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + +++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYKDMHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

800) HPSH417_06660 in NC_017739


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (428),  Expect = 6e-28, Method: Compositional matrix adjust.
 Identities = 85/211 (41%), Positives = 133/211 (64%), Gaps = 3/211 (1%)

Query  61   TQTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVR  120
             + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  121  LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP  180
            ++DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  181  FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDMHYPFVLLEASGNISL  240
            F   +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI +
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDM  252

Query  241  ESINAYAKSGVDAISVGALIHQATFIDMHMK  271
             +I+ +   ++D +S G+L H A  +D  MK
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

801) nadC in NC_014562


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (428),  Expect = 7e-28, Method: Compositional matrix adjust.
 Identities = 112/268 (42%), Positives = 179/268 (67%), Gaps = 3/268 (1%)

Query  32   ALKEDLGGEIDADRDITAQLLPAETQAHAQVITREAGVFCGKRWVEEVFIQLGSHVTLN-  90
            +LK  L  +++++   T  ++  + QA   ++++EAGV+ G    + VF  ++++VT++ 
Sbjct  16   TLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQN  75

Query  91   -WHVEDRDRIEADQLLFEIEGParllltaertalNFVQTLSGVATEVSRYVALLAGSQTQ  149
              +  D DR+ +++L++EI G+ R LLT ER ALNF+Q LSG+A+  + YV  L++ + +
Sbjct  76   PHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK  135

Query  150  LLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSDAYLIKENHIIASGSIAQAVERAQWLQP  209
            ++DTRKT P LR   KYAV  GGG NHR+ LSDA ++K+NHI A GS+ +A+ +A+   P
Sbjct  136  VFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAP  195

Query  210  -DvpvevevesleelrqaleaeaDIVMLDNFSLEAMREAVELNQGRTLLEVSGNVTETTL  268
                VEVEVESL    +A  A  DI+MLDN SLE + +A+ L  GR+ +E SGN+  TT+
Sbjct  196  FVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTI  255

Query  269  PQIALTGVDYVSVGALTKHVRALDLSMR  296
            +++   ++DYVS G+LT   ++LD+SM+
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

802) HPCU_06920 in NC_017358


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (427),  Expect = 7e-28, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 133/210 (64%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + +++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDMHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

803) HPSH112_06795 in NC_017741


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (427),  Expect = 7e-28, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 133/210 (64%), Gaps = 3/210 (1%)

Query  62   QTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRL  121
            + +KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + +++
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKV  136

Query  122  LDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPF  181
            +DTRKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  TAKIEIECESFEEAKNAMNAGADIVMCDNMSVLETKEIAAYRDMHYPFVLLEASGNISLE  241
               +E+E ES+  A +A  AG DI+M DNMS+ +  +  +    +     +E SGNI + 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

804) nadC in NC_017360


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (426),  Expect = 8e-28, Method: Compositional matrix adjust.
 Identities = 85/207 (42%), Positives = 131/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKKRFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDT  124
            KD  R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +VEAL  ++++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAVYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DN+S+ +  +       +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

805) nadC in NC_010528


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (427),  Expect = 8e-28, Method: Compositional matrix adjust.
 Identities = 99/242 (41%), Positives = 161/242 (67%), Gaps = 3/242 (1%)

Query  46   AHARVIVRESAVLCGQPWFDACMRAVDPALAVRWLHQ--EGERMAPDSVVCEITGPARSL  103
            A   ++ +E++VL G   F+      D+ ++ +  HQ  +G+R++++ +V EI G+ RSL
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  104  LTAERPSLNFLQLLSGVATATRRYADLIAGTRARVLDTRKTLPGLRLAQKYAVRIGGGEN  163
            LT ER +LNFLQ LSG+A+ T  Y + +++ R +V+DTRKT P LRL +KYAVR+GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  164  QRLALYDGILIKENHiaaagsigaamraalalDTQAS-VQIeveslaeleealaagaTSV  222
            +R+ L D+I++K+NHIAA GS+  A+  A A       V++EVESLA  EEA AAG   +
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  223  LIDNFTVPMMQDAVKINQGRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYS  282
            ++DN ++  +++A+ +  GR+ +E SG ++  TI  F   ++D +S G+LT   ++ D+S
Sbjct  222  MLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

Query  283  LR  284
            ++
Sbjct  282  MK  283

806) M1627_1279 in NC_012632


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (426),  Expect = 9e-28, Method: Compositional matrix adjust.
 Identities = 97/236 (42%), Positives = 146/236 (62%), Gaps = 8/236 (3%)

Query  45   KDSGISAG----NRFVIPFLNYLGFSNINGEKDGSEVNKGDVVL-IFEGNADVLTVERLI  99
            K++G+ AG    +R    F   + F N +  KDG  +  GD+VL I+ +   +LT ER+ 
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  100  LNFLGKLSGIATITNLMVKRAREVNPNVRISGTRKTTPGFRLFEKYAIEVGGD-PHRYNL  158
            LNFL  LSGIA++T   V      +  +++ +TRKTTP +RLFEKYA+ VGG+  HR+NL
Sbjct  109  LNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNL  166

Query  159  SDAVLIKDNHIALYGNIEELIKRVKSSVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNM  218
            SDA+++KDNHIA  G+++  I + ++  +F K++EVEV S   A  A  AG D I+LDNM
Sbjct  167  SDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNM  226

Query  219  KPYEILPIVNELKGKVILEASGGITPDNVVDYARTGVDIISSGYTTHSSRSLDFSL  274
               +I   +  + G+  +E SG I    +  +   ++D +SSG  THS++SLDFS+
Sbjct  227  SLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

807) HCW_00960 in NC_017737


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  117 bits (426),  Expect = 9e-28, Method: Compositional matrix adjust.
 Identities = 85/209 (41%), Positives = 133/209 (64%), Gaps = 3/209 (1%)

Query  63   NINDKECFKPKDTLMEIRGNFSMLLKVERTLLNILQHSSGIATLTRRFVEALNSKKVRLL  122
            +++D + + + D ++EI G+   LL  ER  LN+LQH SGIA++T  +VEAL   +++++
Sbjct  78   QFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVF  137

Query  123  DTRKTRPLLRSFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKNFLEHAKKSLPFT  182
            DTRKT P LR FEKY+V  GG+ NHR+ L DA+MLKD H+  V  +++ + +A+   PF 
Sbjct  138  DTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFV  197

Query  183  AKIEIECESFEEAKNAMSAGADIVMCDNMTTEQTKEIVAYRNTHYPFVLLEASGNISLET  242
              +E+E ES+  A +A +AG DI+M DNM+ EQ  + ++    +     +E SGNI + T
Sbjct  198  KMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTT  254

Query  243  IHSYAQSGVDAISVGALIHQATFIDMHMK  271
            I  +   ++D +S G+L H A  +D  MK
Sbjct  255  ISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

808) Afer_0958 in NC_013124


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  116 bits (425),  Expect = 1e-27, Method: Compositional matrix adjust.
 Identities = 104/247 (43%), Positives = 160/247 (65%), Gaps = 13/247 (5%)

Query  38   RLELRARDEGVLAGSNTAEVVlrataarlgaaaPTIEWSAHDADALEPGQLIAELAGSNR  97
            ++ L A++ GVLAG    + V+    A +    P       D+D L +G+L+ E+ GS R
Sbjct  43   KVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNP---HQFKDGDRLTSGDLVLEIIGSVR  99

Query  98   VLLAAERTMLNLLTHLSGVATTTARAVAEIADTRCRLRDTRKTLPGMRGLEKAAVRAGGG  157
             LL+ ER  LN+L HLSG+A+ TA  V  ++D R ++ DTRKT P +R +EK AVR GGG
Sbjct  100  SLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGG  159

Query  158  ENHRFSLDDAILLKDNHLAQ-APLEHLVAAAR--QRFGDLPIevevddldgleealaldv  214
             NHRF+L DAI+LKDNH+A  ++++  +A AR    F  + +EVEV+ L + EEA A +V
Sbjct  160  YNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM-VEVEVESLAAAEEAAAAGV  218

Query  215  PMVLLDNFTLEATRDAVRLNGGRAKLESSGGL---RPGRLREVALTGVDYLAVGWITHSA  271
             +++LDN +LE   +A+ L +GR+++E SG +     +R+R +A   +DY++ G +THSA
Sbjct  219  DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLA---IDYVSSGSLTHSA  275

Query  272  PSLDLGL  278
             SLD+++
Sbjct  276  KSLDFSM  282

809) nadC in NC_017093


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  116 bits (424),  Expect = 1e-27, Method: Compositional matrix adjust.
 Identities = 85/204 (42%), Positives = 133/204 (66%), Gaps = 3/204 (1%)

Query  79   NDGDRVRRGDVLARVTGPTRALLTAERTALNLISRMSGVATHTRKWAEILEGTGATVLDT  138
            +DGDR+  GD++  + G+ R+LLT ER ALN++ ++SG+A+ T    E L +    V+DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  139  RKTTPGLRALEKYAVRVGGGTNKRMGLYDVAMIKDNHKLAAGSITAAYQLVR--QTFPDV  196
            RKTTP LR +EKYAVRVGGG N R  L D  M+KDNH  A GS+  A    R    F  +
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  197  AVQVEVTTLEEAREAVEAGATFLLCDNMRPELLTEVVAAVGDRAELEATGNLTLETaaay  256
             V+VEV +L  A EA  AG  +++ DNM  E + + ++ +++R+ +E +GN+ + T + +
Sbjct  200  -VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRF  258

Query  257  aaTGVNYLSVGGLTHSSPILDIAL  280
             + +++Y+S G+LTHS+  LD+++
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSM  282

810) Syncc9605_2452 in NC_007516


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  116 bits (422),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 99/239 (42%), Positives = 155/239 (65%), Gaps = 5/239 (2%)

Query  41   AKQPGRFCGGPLVQRLFQRLDPAVSLRLLRQ--DGDAVEAGDCLLELQGPATALVAGERT  98
            AK++G + G  + QR+F  +D+ V+++  +Q  DGD + +GD +LE+ G+  +L++ ER 
Sbjct  48   AKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERV  107

Query  99   ALNLAMRLSGIATATAALVAQLEGSGVRLADTRKTTPGLRLLEKYAVRCGGGINHRMGLD  158
            ALN+  +LSGIA+ TAA V  L +  +++ DTRKTTP LRL+EKYAVR GGG NHR  L 
Sbjct  108  ALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLS  167

Query  159  DAAMLKENHiawaggitaaiaaVREQAPWPTAVIVEAESEAQALEAVQAGANGVLLDEFS  218
            DA MLK+NHIA  G++  AIA  R  AP    V VE ES A A EA  AG + ++LD+ S
Sbjct  168  DAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMS  227

Query  219  PEQLTQLVPRLRDCSSRGVVLEASGIQPEQLQAYASTGIDLISTSAPVTRSRWLDLSMR  277
             EQ+ Q +  +   ++R+ +  ++ I+   +  + + +ID +S+++    ++ LD+SM+
Sbjct  228  LEQIEQAITLI---AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

811) nadC in NC_017367


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  116 bits (422),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 84/207 (41%), Positives = 130/207 (63%), Gaps = 3/207 (1%)

Query  65   NDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            +D +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKSAMNAGADIVMCDNMSVLETKEIAAYRDVHYPFVLLEASGNISLESIN  244
            +E+E ES+  A  A  AG DI+M DNMS+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

812) nadC in NC_007973


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 106/249 (43%), Positives = 166/249 (67%), Gaps = 9/249 (3%)

Query  43   DKPVHARV--IVREAAVLCGRPWFDACMQAIDERLQVTWQK----EEGARLAPDDVVCEI  96
            D   +A+V  + +EA+VL G   F+     +D   +VT Q+     +G RL+++D+V EI
Sbjct  37   DHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA--EVTFQNPHQFKDGDRLTSGDLVLEI  94

Query  97   TGPARALLTAERPSLNFLQLLSGVASATRRYADLIADTRARVLDTRKTLPGLRLAQKYAV  156
             G+ R+LLT ER +LNFLQ LSG+AS T  Y + ++D R +V+DTRKT P LRL +KYAV
Sbjct  95   IGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAV  154

Query  157  RIGGGENQRLALYDGILIKENHiaaaggiaaameaalalgT-DASIQievesiaeleeal  215
            R+GGG N+R+ L D+I++K+NHIAA G++  A+  A A +     +++EVES+A  EEA 
Sbjct  155  RVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAA  214

Query  216  aagaTSVLIDNFSLEMMREAVAINRERALLEVSGGVNYETIRRFAETGVDRISVGALTKD  275
            AAG   +++DN SLE + +A+++   R+ +E SG ++  TI RF   ++D +S G+LT  
Sbjct  215  AAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHS  274

Query  276  VRATDYSLR  284
             ++ D+S++
Sbjct  275  AKSLDFSMK  283

813) K747_08775 in NC_021215


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 85/207 (42%), Positives = 130/207 (63%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSALETKEIAAYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS  +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

814) K748_04005 in NC_021882


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 85/207 (42%), Positives = 130/207 (63%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSALETKEIAAYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS  +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

815) K749_05600 in NC_021216


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 85/207 (42%), Positives = 130/207 (63%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNMSALETKEIAAYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DNMS  +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

816) nadC in NC_017382


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (420),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 84/207 (41%), Positives = 131/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDMHYPFILLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DN+S+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

817) nadC in NC_017365


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (420),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 86/210 (41%), Positives = 131/210 (63%), Gaps = 9/210 (4%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKNFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  +++ +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKSAMNAGADIVMCDNMSVLETKEIAAY---RDMYYPFVLLEASGNISLE  241
            +E+E ES+  A  A  AG DI+M DNMS+ +  +  +    R        +E SGNI + 
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR------IECSGNIDMT  253

Query  242  SINAYAKSGVDAISVGALIHQATFIDMHMK  271
            +I+ +   ++D +S G+L H A  +D  MK
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

818) nadC in NC_017366


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 84/207 (41%), Positives = 131/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDMHYPFVLLEASGNISLESVN  244
            +E+E ES+  A +A  AG DI+M DN+S+ +  +  +    +     +E SGNI + +++
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAVSVGALIHQATFIDMHMK  271
             +   ++D VS G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

819) nadC in NC_020509


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 84/207 (41%), Positives = 131/207 (64%), Gaps = 3/207 (1%)

Query  65   KDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDT  124
            KD +R+ + D ++EI G    LL  ER  LN+LQH SGIA++T+ +V AL  + ++++DT
Sbjct  80   KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDT  139

Query  125  RKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAK  184
            RKT P LR+FEKY+V  GG+ NHR+ L DA+MLKD H+  V  ++  +++AR   PF   
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  185  IEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDMHYPFVLLEASGNISLESIN  244
            +E+E ES+  A +A  AG DI+M DN+S+ +  +  +    +     +E SGNI + +I+
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTIS  256

Query  245  AYAKSGVDAISVGALIHQATFIDMHMK  271
             +   ++D +S G+L H A  +D  MK
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFSMK  283

820) Intca_0615 in NC_014830


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (421),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 92/228 (41%), Positives = 144/228 (64%), Gaps = 5/228 (2%)

Query  61   VLQAVAELFGTEVP-RVEVVTPDGTRIEPGDVIARLEGSTRVILTAERTILNIMSRLTGV  119
            V+Q V  LF++EV  +      DG R+ +GD++  + GS R +LT ER  LN++ +L+G+
Sbjct  59   VFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGI  118

Query  120  ATHTRRWADALEGTSTRVLDTRKTTPGLRLLEKYAVRAGGGTNKRMGLYDVAMVKDNHKL  179
            A+ T    +AL +   +V+DTRKTTP LRL+EKYAVR GGG N R  L D  M+KDNH  
Sbjct  119  ASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIA  178

Query  180  AAGSVAAAYRLVRETFPQVR-IEVEVETPAEAQESYDAGARFIMCDNMAVPVLRETVELL  238
            A GSV  A    R   P V+ +EVEVE+ A A+E+  AG  +IM DNM++  + +++ L+
Sbjct  179  AVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI  238

Query  239  RAAGEPVEIEATGGLTLESVAECAATGVDFVSVGALTHSSPIVDLALD  286
               +    IE +G + + +++   + ++D+VS G+LTHS+  +D+++ 
Sbjct  239  ---AGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

821) nadC in NC_021191


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  115 bits (419),  Expect = 3e-27, Method: Compositional matrix adjust.
 Identities = 93/216 (44%), Positives = 146/216 (68%), Gaps = 5/216 (2%)

Query  68   GGTATFD--QRVDEGTRVVRGDVLAVVSGPTRALLTAERTALNLLCRMSGVATHTRKWAD  125
            ++  TF+  ++  +G R+  GD++  + G+ R+LLT ER ALN+L ++SG+A+ T    +
Sbjct  68   DAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVE  127

Query  126  ELSGTKATVLDTRKTTPGLRVLEKYAVRVGGGTNKRMGLYDVAMIKDNHKLAAGSITAAY  185
             L++ +  V+DTRKTTP LR++EKYAVRVGGG N R  L D  M+KDNH  A GS+  A 
Sbjct  128  ALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAI  187

Query  186  RLVR--DTFPDvavqvevttvaeaeeavaaGADFLLCDNMSPELLRQVVAAVGDRAELEA  243
               R    F    V+VEV ++A AEEA AAG D+++ DNMS E + Q ++ +++R+ +E 
Sbjct  188  AQARAYAPFVK-MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIEC  246

Query  244  TGNLTLETVSAYAATGVDYLSVGGLTHSSPILDIAM  279
            +GN+ + T+S + + ++DY+S G+LTHS+  LD++M
Sbjct  247  SGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

822) H729_08315 in NC_021353


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  114 bits (416),  Expect = 5e-27, Method: Compositional matrix adjust.
 Identities = 103/257 (41%), Positives = 165/257 (65%), Gaps = 11/257 (4%)

Query  15   DITSDALIDDSLTGTAAIIANEPCVVAGICEAEAVFQYFN----IKTNALVSDGQSVEKG  70
            D +++A++D+   +  +++A+E+ V+AG+   + VF  F+    ++      DG+ +  G
Sbjct  29   DYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSG  88

Query  71   DIILEVSGSLKSILSAERTALNFLMRMSGIATVTHSISSKLSHAKVA--ATRKTTPGFRS  128
            D++LE+ GS++S+L+ ER ALNFL ++SGIA++T +    L++ ++    TRKTTP +R 
Sbjct  89   DLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRL  148

Query  129  FEKKAVILGGGDPHRFCLDDLILIKDNHiavvggvaeavikakkF-SFAKKVEVEVESIE  187
            FEK AV +GGG  HRF L D I++KDNHIA VG+V  A+ +A+ + +F K VEVEVES+ 
Sbjct  149  FEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLA  208

Query  188  DAEAAVKSEADIILLDNMSPEKAAKCYSLIKSLNSKIIVEVSGTITPETAQLYDE-CADI  246
             AE A  +  DII+LDNMS E+  +  +LI    ++  +E SG I   T   +     D 
Sbjct  209  AAEEAAAAGVDIIMLDNMSLEQIEQAITLI---AGRSRIECSGNIDMTTISRFRGLAIDY  265

Query  247  ISLGWITHSVRSIHFSL  263
            +S G +THS +S++FS+
Sbjct  266  VSSGSLTHSAKSLDFSM  282

823) nadC in NC_015726


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  114 bits (415),  Expect = 7e-27, Method: Compositional matrix adjust.
 Identities = 97/234 (42%), Positives = 156/234 (67%), Gaps = 3/234 (1%)

Query  54   ESAVLCGQPWFDACMRAVDPALEVRWLQQ--EGARMAPDSVVCEITGPARSLLTAERPSL  111
            E++VL G   F+      D+ +  +  +Q  +G R++++ +V EI G+ RSLLT ER +L
Sbjct  50   EAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVAL  109

Query  112  NFLQLLSGVATATRRYADLIAGTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDG  171
            NFLQ LSG+A+ T  Y + +++ R +V+DTRKT P LRL +KYAVR+GGG N+R+ L D+
Sbjct  110  NFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDA  169

Query  172  ILIKENHIaaagsisaamqaalaldtsaS-VQIevetlaeleealaagaNSVLIDNFTVP  230
            I++K+NHIAA GS+  A+  A A       V++EVE+LA  EEA AAG + +++DN ++ 
Sbjct  170  IMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLE  229

Query  231  MMQDAVRLNRGRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLR  284
             +++A+ L  GR+ +E SG ++  TI  F   ++D +S G+LT   ++ D+S++
Sbjct  230  QIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

824) R2APBS1_2937 in NC_020541


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  114 bits (415),  Expect = 7e-27, Method: Compositional matrix adjust.
 Identities = 113/272 (42%), Positives = 180/272 (67%), Gaps = 4/272 (1%)

Query  14   QIAADVERAFAEDLGPGD-ATAGLLPPDARAHAELTCRDAAVIAGTPWFDACFRRLDPAV  72
            QI   +  A+ ED+ + D +T +++  +++A   L  ++A+V+AG   F+  F  +D+ V
Sbjct  12   QIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEV  71

Query  73   QID--WRVRDGDRVAPGTVICRLSGHARSLVTAERSALNFLQLLSatatvtagyvaatag  130
             ++   + +DGDR+++G ++  + G  RSL+T ER ALNFLQ LS+ A++TA+YV A ++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  131  tavRVLDTRKTIPGLRLAQKYAVRCGGGHNQRMGLYDAVLVKENHiiaagsivaavqaaR  190
              ++V+DTRKT P LRL +KYAVR GGG N+R  L DA+++K+NHI A GS+  A+  AR
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  191  R-lhpelllevevenldeleQALQAGVDRIMLDNFEPAQMREAVRYTAGRVPLEASGNID  249
                   ++EVEVE+L   E+A  AGVD IMLDN    Q+ +A+   AGR  +E SGNID
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNID  251

Query  250  LGTIGDYARTGVDFISVGALTKHVHAIDLSLR  281
            + TI+ +   ++D++S G+LT    ++D+S++
Sbjct  252  MTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

825) Rhom172_0200 in NC_015966


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  113 bits (410),  Expect = 2e-26, Method: Compositional matrix adjust.
 Identities = 124/300 (42%), Positives = 188/300 (63%), Gaps = 23/300 (7%)

Query  5    PITSTDWPPYLDKATLDRMLRQWLAEDIGPGDVTTEATVPPDQQARGLFLAKANGVVAGL  64
            +I STD  P+    TL   LR    ED+ + D +T+A    + QA+  ++AK  GV+AGL
Sbjct  2    SIISTDLTPFQIDDTLKAALR----EDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGL  57

Query  65   QVAARVFQLVDPDVRVCWQQA----DGSRVTAGTLFGTVEGRARSllmaerlalnllQRM  120
             V  RVF L D++V    Q++    DG R+T+G L   + G  RSLL  ER+ALN+LQ++
Sbjct  58   TVFQRVFTLFDAEVT--FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHL  115

Query  121  SGIATATRRLVERVRPYGTKVLDTRKTAPGLRLLDKWAVRLGGGTNHRLGLYDMILIKDN  180
            SGIA+ T   VE +     KV+DTRKT+P LRL++K AVR+GGG NHR+ L D I++KDN
Sbjct  116  SGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDN  175

Query  181  HIVaaggireaieaarrYREQHRLDIPIEIEAQSLEDVDAILATGGVDWILLDNFARRLP  240
            HI A G+++ AI  AR Y    ++   +E+E +SL   +   A++GVD I+LDN      
Sbjct  176  HIAAVGSVQKAIAQARAYAPFVKM---VEVEVESLAAAEEA-AAAGVDIIMLDN------  225

Query  241  DGTLNVEPLREAVRRIGGRFHTEASGNitletaeaiaatGVEAISCGALTHSVQALDLSL  300
               +++E + +A+  I+GR + E SGNI + T   + + +++ +S G+LTHS ++LD+S+
Sbjct  226  ---MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

826) A2cp1_1570 in NC_011891


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  112 bits (408),  Expect = 2e-26, Method: Compositional matrix adjust.
 Identities = 111/253 (44%), Positives = 179/253 (71%), Gaps = 6/253 (2%)

Query  26   TSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFERLGASCTFdradgara----argev  81
            +++A +D  + +   ++AKE  VLAG +V  RVF  ++A  TF+ ++  +     + G++
Sbjct  31   STNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDL  90

Query  82   vgtargTVRALLAAERTALNFLQRLSGVATATRRCADALAAGGGRTRLLDTRKTTPGWRM  141
            V    G+VR+LL+ ER ALNFLQ+LSG+A+ T    +AL  G++R +++DTRKTTP  R+
Sbjct  91   VLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFDTRKTTPNLRL  148

Query  142  LEKAAVRAGGGKNHRFSLGDGVLIKDNHvaacggvaeavrrarasagaMLRVEVEVEDLP  201
            +EK AVR GGG NHRF+L+D++++KDNH+AA G+V  A+ +ARA A  +  VEVEVE L+
Sbjct  149  FEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLA  208

Query  202  GLEEAIAAGADLVLLDNmddaamaeavrraagralleaSGNMTLERLPRVAATGVDFVSM  261
            + EEA AAG D+++LDNM    + +A+   AGR+ +E SGN+ +  ++R  + ++D+VS 
Sbjct  209  AAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSS  268

Query  262  GAVTHSARAVDLA  274
            G++THSA+++D++
Sbjct  269  GSLTHSAKSLDFS  281

827) Vapar_4098 in NC_012791


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  112 bits (408),  Expect = 3e-26, Method: Compositional matrix adjust.
 Identities = 109/268 (41%), Positives = 170/268 (64%), Gaps = 8/268 (2%)

Query  24   LQEDVADGDL-TASLVDPGRRAHARVLAREAAVLCGAPWVEATVRQLDPQARIR--WLCR  80
            L+EDV   D  T ++ D   +A   ++A+EA+VL G    +     +D++  ++     +
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  81   EGERCAADQTVLEIEGtaralltaertalNFLQLLSGVATKTALYVDAVRGTRASIVDTR  140
            +G+R ++++ VLEI G+ R+LLT ER ALNFLQ LSG+A+ TA YV+A+ + R  + DTR
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTR  140

Query  141  KTLPGLRLAQKYAVRTGGGVNHRIGLYDAVLIKENHIaaaggvaaalravapaaqraaFV  200
            KT P LRL +KYAVR GGG NHR+ L DA+++K+NHIAA G+V  A+    + A     V
Sbjct  141  KTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMV  200

Query  201  EVEVETLAQLREALEAGARMVLLDNMDLPTLREAVRINAEAGEDRKAVLEISGGVTLEGL  260
            EVEVE+LA   EA  AG  +++LDNM L  + +A+ + A      ++ +E SG + +  +
Sbjct  201  EVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG-----RSRIECSGNIDMTTI  255

Query  261  RTLADTGVDRISVGALTKDVKAIDFSMR  288
              + + ++D +S G+LT   K++DFSM+
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

828) nadC in NC_016830


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  111 bits (405),  Expect = 4e-26, Method: Compositional matrix adjust.
 Identities = 115/279 (42%), Positives = 202/279 (73%), Gaps = 7/279 (2%)

Query  7    ADLTA-EIEANVRRALLEDIGSGDITAQLIPAER-LAKATIITRDAAIISGTAWVDAVFR  64
            +DLT+ +I+  ++ AL ED+ S D +++ I  ++  AK ++++++A++++G +  + VF 
Sbjct  6    TDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFT  65

Query  65   QLDPRVAVH--WQVRDGDQVNPDQVLFHLEGPARSLLTGERSALNFLQMLSGVATR-ARY  121
             +D+ V+ +   Q +DGD++ ++++++++ G+ RSLLT ER ALNFLQ LSG+A+  A Y
Sbjct  66   LFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAY  125

Query  122  LADFVAGTQVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHiaacggia  181
            +   +++ ++K++DTRKT P LRL +KYAV  GG  NHR+ L DA+++K+NHIAA G++ 
Sbjct  126  VEA-LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQ  184

Query  182  qaiaaahk-iapgKPveveveslaelkealaadadiimldelSLDDMREAVRLNGGKAKL  240
            +AIA A+   +  K VEVEVESLA   EA AA+ DIIMLD++SL+++ +A+ L +G++++
Sbjct  185  KAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI  244

Query  241  EASGGINESTLRPIAETGVDYISIGAMTKDVKAVDLSMR  279
            E SG I+ +T+  +   ++DY+S G++T   K++D+SM+
Sbjct  245  ECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

829) Rmar_0217 in NC_013501


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  111 bits (406),  Expect = 4e-26, Method: Compositional matrix adjust.
 Identities = 121/298 (41%), Positives = 187/298 (63%), Gaps = 19/298 (6%)

Query  5    PITSTDWPPYLDEATLDRLIRQWLAEDIGPGDVTTEATVPPERQARGLFLAKANGVVAGL  64
            +I STD  P+  + TL    +  L ED+ + D +T+A    + QA+  ++AK  GV+AGL
Sbjct  2    SIISTDLTPFQIDDTL----KAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGL  57

Query  65   QVAARVFQLVDPDVHVRWHQA--DGSRVTAGTIFGTVEGRARSllmaerlalnllQRMSG  122
             V  RVF L D++V  +  +   DG R+T+G +   + G  RSLL  ER+ALN+LQ++SG
Sbjct  58   TVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSG  117

Query  123  IATATRRLVERVRPYGTKVLDTRKTAPGLRLLDKWAVRLGGGTNHRLGLYDMILIKDNHI  182
            IA+ T   VE +     KV+DTRKT+P LRL++K AVR+GGG NHR+ L D I++KDNHI
Sbjct  118  IASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHI  177

Query  183  VaaggireaieaarrYREQHRLDIPIEIEAQSLEDVDAILATGGVDWILLDNFARHLPDG  242
             A G+++ AI  AR Y    ++   +E+E +SL   +   A++GVD I+LDN        
Sbjct  178  AAVGSVQKAIAQARAYAPFVKM---VEVEVESLAAAEEA-AAAGVDIIMLDN--------  225

Query  243  TLDVEPLREAVRRIGGRFHTEASGNitletaeaiaatGVEAISCGALTHSVQALDLSL  300
             + +E + +A+  I+GR + E SGNI + T   + + +++ +S G+LTHS ++LD+S+
Sbjct  226  -MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

830) nadC in NC_008313


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  111 bits (404),  Expect = 5e-26, Method: Compositional matrix adjust.
 Identities = 96/234 (42%), Positives = 155/234 (67%), Gaps = 3/234 (1%)

Query  54   ESAVLCGQPWFDACMRALDPALEVHWLQQ--EGARMAHDSVVCEITGPARSLLTAERPSL  111
            E++VL G   F+     +D+ +  +  +Q  +G R++ + +V EI G+ RSLLT ER +L
Sbjct  50   EAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVAL  109

Query  112  NFLQLLSGVATATRRYADLIAGTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDG  171
            NFLQ LSG+A+ T  Y + +++ R +V+DTRKT P LRL +KYAVR+GGG N+R+ L D+
Sbjct  110  NFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDA  169

Query  172  ILIKENHiaaagsisaamqaalalDTRAS-VQIevetlaeleealaagaKSVLIDNFTVP  230
            I++K+NHIAA GS+  A+  A A       V++EVE+LA  EEA AAG   +++DN ++ 
Sbjct  170  IMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLE  229

Query  231  MMQDAVRINRGRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLR  284
             +++A+ +  GR+ +E SG ++  TI  F   ++D +S G+LT   ++ D+S++
Sbjct  230  QIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

831) nadC in NC_017955


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  111 bits (403),  Expect = 7e-26, Method: Compositional matrix adjust.
 Identities = 99/243 (41%), Positives = 155/243 (64%), Gaps = 4/243 (1%)

Query  68   GTADLVARADGVVAGLPVAARVFtrlapgaaltagaadgdrVR--RGDVLLTVRGPVRAL  125
            +   L A+  GV+AGL V  RVFT + +  ++       D  R   GD++L + G+VR+L
Sbjct  42   AKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSL  101

Query  126  LAAERSALNIASRASGIATHTRAWADAVAGTGAVVLDTRKTTPGLRPLEKYAVRCGGGSN  185
            L+ ER ALN+  + SGIA+ T A  +A+++    V+DTRKTTP LR +EKYAVR GGG N
Sbjct  102  LTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN  161

Query  186  KRMGLYDVAMVKDNHvaaagsvaaavalvreraprIT-VQVECDTVAQVTEAVDAGADFL  244
             R  L D  M+KDNH+AA GSV  A+A  R  AP +  V+VE +++A   EA  AG D++
Sbjct  162  HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDII  221

Query  245  LLDNMTTDQLREVVALVGDLDVELEATGGLTLAVAREVADTGVDYLSVGALTHSSPILDL  304
            +LDNM+ +Q+ + ++L+++    +E +G + ++      + ++DY+S G+LTHS+  LD+
Sbjct  222  MLDNMSLEQIEQAITLIAG-RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDF  280

Query  305  ALD  307
            ++ 
Sbjct  281  SMK  283

832) nadC in NC_014659


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  110 bits (399),  Expect = 1e-25, Method: Compositional matrix adjust.
 Identities = 89/214 (42%), Positives = 145/214 (68%), Gaps = 4/214 (1%)

Query  72   NYEVLDRVADGTRVQPGDAVLTVNAPTRGLLTAERTMLNLMCHLSGIATATSAWVDAVAG  131
             ++  ++  DG R+ +GD VL + ++ R+LLT ER  LN++ HLSGIA+ T+A V+A+++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  132  TECKIRDSRKTLPGMRGLQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvvsalravr  191
               K+ D+RKT P +R ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+   R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  192  avaPGIE-CEVEVDDLTQldevlaegvelvllDNFPLWQTQVAVQRRDTVSPSTKLESSG  250
            A AP +   EVEV+ L+  +E  A GV++++LDN +L Q + A+     ++  +++E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAI---TLIAGRSRIECSG  248

Query  251  GLTIDVASDYAATGVDYLAVGALTHSVSVLDLGL  284
             + +   S + + ++DY++ G+LTHS   LD+++
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

833) nadC1 in NC_015948


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  109 bits (397),  Expect = 2e-25, Method: Compositional matrix adjust.
 Identities = 110/268 (42%), Positives = 163/268 (61%), Gaps = 16/268 (5%)

Query  11   LHEDVGHHDVTNDV----PGTTEGRLVAKESGVVAGLDAATAVFEYLDCAV--ETP--VD  62
            L+EDV  +D + +      G +   L AKE+GV+AGL     VF  +D  V  + P    
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  63   SGAAIDAGDVVLRVDGPAQSVLRGERVAVNITGHASGVATKTRaavdaaesaatdstPRI  122
             G  + +GD+VL + G+ +S+L  ERVA+N+  H SG+A+ T     A   A  D   ++
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMT----AAYVEALGDDRIKV  136

Query  123  AGTRKTTPGLRGIEKRAVAAGGGDTHRLDLSHMVMVKDNHIAEMGLVD-AIEHFRERASF  181
             +TRKTTP LR +EK AV  GGG  HR++LS+ +M+KDNHIA +G V+ AI + R  A+F
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  182  ATKLDveveapedapraaeagadIVLLDNMSPAETERAVDRVAASTSGALTEASGGITVA  241
               ++VEVE+   A  AA AG DI++LDNMS  + E+A+  +A+ +     E SG I ++
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMT  253

Query  242  DVPAYAETGVDIISMGSLTHSAPTLDFS  269
             ++ +   ++D +S GSLTHSA +LDFS
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFS  281

834) Htur_0528 in NC_013743


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  108 bits (393),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 109/264 (42%), Positives = 159/264 (61%), Gaps = 12/264 (4%)

Query  11   LREDVGHHDVTNQV----PGETTGRLVAKESgvaagleaaaavFEYLGVAVN----EALE  62
            LREDV  +D + +      G++   L AKE+GV AGL     VF  ++  V     + + 
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  63   DGTAIDSGDELLRVEGGAREVLRGERVAVNLAGHASGIATRTNEVVERARTESDDVRVAA  122
            DG  + SGD +L + G+ R +L  ERVA+N+  H SGIA+ T   VE      D ++V  
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA--LGDDRIKVFD  138

Query  123  TRKTTPGLRGVEKRAVGAGGGDTHRLDLSHMVMVKDNHVAEMG-LEGAIEHFQARTSFAT  181
            TRKTTP LR  EK AV  GGG  HR++LS+ +M+KDNH+A +G ++ AI + +A ++F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  182  KLDVEVEAVEDAPRAADAGADIVLLDNMSPAETReavdlladyaalaeaSGGITLETVAD  241
             ++VEVE++  A  AA AG DI++LDNMS  +  E    L    +  E SG I + T++ 
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQI-EQAITLIAGRSRIECSGNIDMTTISR  257

Query  242  YAATGVDVISMGSLTHSAPSLDLS  265
            + + ++D +S GSLTHSA SLD+S
Sbjct  258  FRGLAIDYVSSGSLTHSAKSLDFS  281

835) Smal_1368 in NC_011071


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  108 bits (394),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 97/238 (41%), Positives = 155/238 (66%), Gaps = 3/238 (1%)

Query  43   LLCKQDAVIAGRPWFDATHRALDPDVRIE--WRVADGDAVTAGTVLALLHGRSRSLVSAE  100
            L+ K+ +V+AG   F+     +D++V ++   +  DGD +T+G ++  + G  RSL++ E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  101  RTSLNFLQTLSatatttaRYVAAVEGTGTRILDTRKTLPGLRLAQKYAVRCGGGENHRFG  160
            R +LNFLQ LS+ A+ TA YV A+ +   +++DTRKT P LRL +KYAVR GGG NHRF 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  161  LYDTVMLKENHIraagslaaavaaarrQWPQLPLV-VEVEDLEQLRQALEAGCERILLDD  219
            L D++MLK+NHI A GS+  A+A AR   P + +V VEVE L    +A  AG + I+LD+
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  220  FSPDLRREAVRITAGRIPLEvsgsvglgglRSIAEDGVDCISIGGLTKHVQAIDLSLK  277
             S +   +A+ + AGR  +E SG++++  +  +   ++D +S G+LT   +++D+S+K
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

836) nadC in NC_017671


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  105 bits (380),  Expect = 4e-24, Method: Compositional matrix adjust.
 Identities = 101/238 (43%), Positives = 157/238 (66%), Gaps = 3/238 (1%)

Query  43   LLCKQDGVIAGRPWFDATHRALDPDVRIE--WQVSDGDAVTAGTVLALLHGRSRSLVSAE  100
            L+ K+ GV+AG   F+     +D++V ++   Q  DGD +T+G ++  + G  RSL++ E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  101  RTSLNFLQTLSgtatttaryvaavagtgtRILDTRKTLPGLRLAQKYAVRCGGGENHRFG  160
            R +LNFLQ LSG A+ TA YV A+++   +++DTRKT P LRL +KYAVR GGG NHRF 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  161  LYDTVMLKENHIRaagsladavagaRRQWPALPLV-VEVEDLAQLRQALDAGCERILLDD  219
            L D++MLK+NHI A GS+  A+A AR   P + +V VEVE LA   +A  AG + I+LD+
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  220  FSPDLRREAVRITAGRIPLEvsgsvglgglRSIAEDGVDCISIGGLTKHVQAIDLSLK  277
             S +   +A+ + AGR  +E SG++++  +  +   ++D +S G+LT   +++D+S+K
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

837) nadC in NC_016070


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  104 bits (379),  Expect = 4e-24, Method: Compositional matrix adjust.
 Identities = 95/209 (46%), Positives = 131/209 (63%), Gaps = 8/209 (3%)

Query  69   DGETAKAGECFLYIRGPKPDLLKVERVVLNLLMRASGIATATRRILEAARAANPRVKVAA  128
            DG+   +G+  L I G+   LL  ERV LN+L + SGIA+ T   +EA   ++ R+KV  
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFD  138

Query  129  TRKTTPFLRYIEKKAVAIGGGDPHRFSLSDAVLIKDNHIKAVGGLERALELARKTAPFTA  188
            TRKTTP LR +EK AV +GGG  HRF+LSDA+++KDNHI AVG++++A+  AR  APF  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  189  KIEVEVENVADAIKAAELGADIIMLDNMRPEEVAevdrrlrerglrervvleASGGIRED  248
             +EVEVE++A A  AA  G DIIMLDNM  E++           +  R  +E SG I   
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIE-----QAITLIAGRSRIECSGNIDMT  253

Query  249  NAADYAKY-VDVISVGALTHSVKAVDMSM  276
              + +    +D +S G+LTHS K++D SM
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

838) nadC in NC_018289


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  104 bits (379),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 100/237 (43%), Positives = 158/237 (67%), Gaps = 4/237 (1%)

Query  48   REPGVIAGVDVALLVLDEMIGADRYRVLHRVDDGAQLDAKQTVLTVEAPTRELLTAERTM  107
            +E+GV+AG+ V   V+    +   ++  H+  DG +L + + VL + ++ R LLT ER  
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  108  LNLLCHLSGvatataawvdavagtKAKIRDTRKTLPGLRLLQKYAVRVGGGVNHRMGLGD  167
            LN+L HLSG+A+ TAA V+A+++ + K+ DTRKT P LRL++KYAVRVGGG NHR  L+D
Sbjct  109  LNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSD  168

Query  168  AALIKDNHvaaagsvvaalkavREEAPGLP-CEVEVDSLEQldevlalgvelvlldNFPV  226
            A ++KDNH+AA GSV  A+   R  AP +   EVEV+SL   +E  A GV++++LDN ++
Sbjct  169  AIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSL  228

Query  227  WQTQMAVQRRDARAPETLLESSGGLTLDTAADYAGTGVDYLAIGALTHSVRVLDLGL  283
             Q + A+    +R+    +E SG + + T + + G ++DY++ G+LTHS + LD+++
Sbjct  229  EQIEQAITLIAGRSR---IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

839) nadC in NC_008596


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  104 bits (379),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 100/237 (43%), Positives = 158/237 (67%), Gaps = 4/237 (1%)

Query  51   REPGVIAGVDVALLVLDEMIGADRYRVLHRVDDGAQLDAKQTVLTVEAPTRELLTAERTM  110
            +E+GV+AG+ V   V+    +   ++  H+  DG +L + + VL + ++ R LLT ER  
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  111  LNLLCHLSGvatataawvdavagtKAKIRDTRKTLPGLRLLQKYAVRVGGGVNHRMGLGD  170
            LN+L HLSG+A+ TAA V+A+++ + K+ DTRKT P LRL++KYAVRVGGG NHR  L+D
Sbjct  109  LNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSD  168

Query  171  AALIKDNHvaaagsvvaalkavREEAPGLP-CEVEVDSLEQldevlalgvelvlldNFPV  229
            A ++KDNH+AA GSV  A+   R  AP +   EVEV+SL   +E  A GV++++LDN ++
Sbjct  169  AIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSL  228

Query  230  WQTQMAVQRRDARAPETLLESSGGLTLDTAADYAGTGVDYLAIGALTHSVRVLDLGL  286
             Q + A+    +R+    +E SG + + T + + G ++DY++ G+LTHS + LD+++
Sbjct  229  EQIEQAITLIAGRSR---IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

840) nadC in NC_008268


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  104 bits (379),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 90/213 (43%), Positives = 143/213 (68%), Gaps = 4/213 (1%)

Query  76   YQVLDRVADGTRVAPGQAVLTVTAPTQGLLTAERTMLNLVCHLSGIATATSAWVDAVEGT  135
            +Q  ++  DG R+++G+ VL + ++ ++LLT ER  LN++ HLSGIA+ T+A V+A+ + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  136  GAKIRDSRKTLPGLRGLQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvvaalravra  195
              K+ D+RKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+   RA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  196  aaPDIE-CEVEVDSLEQldevlaenvelvlldnFPLWQTQIAVQRRDANAPGTKLESSGG  254
             AP +   EVEV+SL   +E  A  V++++LDN +L Q + A+      A  +++E SG 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAI---TLIAGRSRIECSGN  249

Query  255  LTLDVAAEYAGTGVDYLAVGALTHSVTVLDLGL  287
            + +   + + G ++DY++ G+LTHS   LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

841) MFS40622_1764 in NC_013887


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  103 bits (373),  Expect = 1e-23, Method: Compositional matrix adjust.
 Identities = 93/213 (44%), Positives = 128/213 (61%), Gaps = 12/213 (5%)

Query  68   FNDGEEAYGN--ILEFEGEARTILMVERTALNLLMHLSGIATMTnrvvkkaksvnknvRI  125
            F+DG+   +   +LE+ G  R++L  ER ALN+L HLSGIA+MT   V          ++
Sbjct  79   FKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRI--KV  136

Query  126  ACTRKTLPLLSPLQKYAVYVGGGDTHRFRLDDSVLIKDNHIAIVG-VREAIKKAKESVSF  184
              TRKT P L  ++KYAV VGGG  HRF L D++++KDNHIA VG V+ AI +A+   +F
Sbjct  137  FDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPF  196

Query  185  TKKIEIEVSNleelkealeeRADIIMLDNFKLEDIEKALKIIDEFERKTNFRPIIEVSGG  244
             K +E+EV +L    EA     DIIMLDN  LE+IE+A+ +I         R+ IE SG 
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG-------RSRIECSGN  249

Query  245  IKEDNILEYAKYNVDVISMGALTHSVKSVDMSL  277
            I    I  +    +D +S G+LTHS KS+D S+
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

842) nadC in NC_012522


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  103 bits (372),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 90/213 (43%), Positives = 143/213 (68%), Gaps = 4/213 (1%)

Query  77   YEVLDRVADGTRITPGRAVLTVSAPTQGLLTAERTMLNLVCHLSGIATATSAWVDAVEGT  136
            ++  ++  DG R+T+G  VL + ++ ++LLT ER  LN++ HLSGIA+ T+A V+A+ + 
Sbjct  73   FQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDD  132

Query  137  GAKIRDSRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvvaalravra  196
              K+ D+RKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+   RA
Sbjct  133  RIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARA  192

Query  197  aaPDIE-CEVEVDSLAQldevlaenvelvlldnFPLWQTQIAVQRRDANAPATKLESSGG  255
             AP +   EVEV+SLA  +E  A  V++++LDN +L Q + A+      A  +++E SG 
Sbjct  193  YAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAI---TLIAGRSRIECSGN  249

Query  256  LTLDVAAEYAATGVDYLAVGALTHSVTVLDLGL  288
            + +   + + + ++DY++ G+LTHS   LD+++
Sbjct  250  IDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

843) BurJV3_1358 in NC_015947


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  102 bits (370),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 100/238 (43%), Positives = 157/238 (66%), Gaps = 3/238 (1%)

Query  43   LLCKQDGVIAGRPWFDATHRALDPDVRID--WQVSEGDAVTAGTVLALLHGRSRSLVSAE  100
            L+ K+ GV+AG   F+     +D++V ++   Q  +GD +T+G ++  + G  RSL++ E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  101  RTSLNFLQTLSgtatttaryvaavagtgtRILDTRKTLPGLRLAQKYAVRCGGGENHRFG  160
            R +LNFLQ LSG A+ TA YV A+++   +++DTRKT P LRL +KYAVR GGG NHRF 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  161  LYDTVMLKENHIraagslaaavagarrQWPALPLV-VEVEDLAQLRQALEAGCERILLDD  219
            L D++MLK+NHI A GS+  A+A AR   P + +V VEVE LA   +A  AG + I+LD+
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  220  FSPDLRREAVRITAGRIPLEvsgsvglgglRSIAEDGVDCISIGGLTKHVQAIDLSLK  277
             S +   +A+ + AGR  +E SG++++  +  +   ++D +S G+LT   +++D+S+K
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

844) Cwoe_4594 in NC_013739


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  102 bits (369),  Expect = 3e-23, Method: Compositional matrix adjust.
 Identities = 105/234 (45%), Positives = 155/234 (67%), Gaps = 4/234 (1%)

Query  64   KAPGVVYGFELAERAFRALDPGVVLE--RAVAEGVW-RDGGPVLTATGNaralltaerta  120
            K +GV+ G+ + +R F  +D+ V ++  +   +G +   G+ VL   G+ R+LLT ER A
Sbjct  49   KEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVA  108

Query  121  lNFLGRLSGVATLTARCVRALEGTGARVLDTRKTTPGLRMVEKAAVHAGGGVNHRIGLFD  180
            LNFL +LSG+A++TA  V AL +   +V+DTRKTTP LR+ EK AV+ GGG NHR+ L D
Sbjct  109  LNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSD  168

Query  181  EILIKENHaaaaggvgeavrraraarPDLP-IEVEVTDlaeleealaagaaRIMLDNMDL  239
             I++K+NH AA G+V  A+ +ARA  P +  +EVEV  LA  EEA AAG   IMLDNM L
Sbjct  169  AIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSL  228

Query  240  ATMREAVERAAGRASLEASGGVTLDALRAIGETRVDFISVGALTHSAPALDLSL  293
              + +A+   AGR+ +E SG + + ++  +    +D++S G+LTHSA +LD+S+
Sbjct  229  EQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

845) Hmuk_1495 in NC_013202


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  102 bits (369),  Expect = 3e-23, Method: Compositional matrix adjust.
 Identities = 110/266 (42%), Positives = 164/266 (62%), Gaps = 14/266 (5%)

Query  11   LREDVGHHDVTNDV----PGETTGRLVAKEagvvagldaaaavFDYLDVAVT----ERAD  62
            LREDV  +D + +      G++   L AKEAGV+AGL     VF  +D  VT    ++  
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  63   DGTLIEPGDVVLRVEGPAQAVLRGERVAVNITGHAAGIATKTdaavaaarevdedvrIAA  122
            DG  + +GD+VL + G+ +++L  ERVA+N+  H +GIA+ T A V A  +      +  
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIK--VFD  138

Query  123  TRKTTPGLRGVEKRAVVAAGGDTHRLDLSHMVMVKDNHVAEMG-LEGAIEHFRERASFAT  181
            TRKTTP LR  EK AV  +GG  HR++LS+ +M+KDNH+A +G ++ AI + R  A+F  
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  182  QLDVEVeesadaplaaeagaDIVLLDNMTPEETREAVDLVAESDADALTEASGGITVETV  241
             ++VEVE  A A  AA AG DI++LDNM+ E+  +A+ L+A        E SG I + T+
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTI  255

Query  242  PDYAATGVDVLSMGSLTHSAPTLDLS  267
            + + + ++D +S GSLTHSA +LD+S
Sbjct  256  SRFRGLAIDYVSSGSLTHSAKSLDFS  281

846) Metfor_2688 in NC_019943


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  102 bits (368),  Expect = 3e-23, Method: Compositional matrix adjust.
 Identities = 109/269 (41%), Positives = 175/269 (66%), Gaps = 14/269 (5%)

Query  13   LKEDTPAGDVTSEAVI-PDITCTAAIRAEQDGTLAGIEEATLLFTHFGIAVTNGK----R  67
            L+ED  + D +++A++  +     ++ A + G LAG+     +FT F+  VT  +    +
Sbjct  21   LREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK  80

Query  68   DGDTVRRDESVLTFSGTAKNILLVERTALNILGRMSGIATRTAAMAAIVRRVNPACRVAG  127
            DGD +  ++ VL + G+ +++L  ER ALN+L ++SGIA+ TAA    +   +   +V +
Sbjct  81   DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRIKVFD  138

Query  128  TRKTCPGFRRFDKKAVQIGGGDPHRMNLSDGILIKDNHLAIV-PLEKAIHKARAHSAY-K  185
            TRKT P +R F+K AV++GGG  HR NLSD+I++KDNH+A V +++KAI +ARA +++ K
Sbjct  139  TRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVK  198

Query  186  KievevesaadavraaragadiiMLDNMMPLQVQETLASLQENGVRDRVVIEISGGIDEE  245
             +EVEVES A A  AA AG DIIMLDNM   Q++++++ +     R R  IE SG ID  
Sbjct  199  MVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG---RSR--IECSGNIDMT  253

Query  246  TLPNYAACGVDVISMGSLTHSVRNISFSL  274
            T++ + + ++D +S GSLTHS +++ FS+
Sbjct  254  TISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

847) A35E_00349 in NC_018420


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  101 bits (367),  Expect = 4e-23, Method: Compositional matrix adjust.
 Identities = 113/275 (42%), Positives = 177/275 (65%), Gaps = 5/275 (1%)

Query  24   PLSVNMALKEDLGGNVDAHADVSALLLPVESKAKAIIFAREHGIFCGQLWLEEVFKQLGG  83
            P+ ++ +LK  L  +V+++   +  ++  +++AK  +FA+E G++ G   ++ VF  +++
Sbjct  10   PFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDA  69

Query  84   GVAIEW---FVKDGDKVFPNHSLCRLSGSTRLLLTGERTALNFIQMLCGVASEVRRYVAA  140
             V+++    F KDGD++ + + +  + GS R LLT ER ALNF+Q L G+AS    YV A
Sbjct  70   EVTFQNPHQF-KDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEA  128

Query  141  IAdttttvvdtRKTIPGLRTALKYAVLCGGGSNHRLGLDDAFLIKENHiiaagsisnaia  200
            ++D    V DTRKT P LR   KYAV  GGG NHR+ L DA+++K+NHI A GS+ +AIA
Sbjct  129  LGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIA  188

Query  201  gala-lsnDlpveveveslnelvQALDAGADIIMLDNFNYHDIRKAVEITRKRSVLEVSG  259
             A A  +    VEVEVESL    +A  AG DIIMLDN + ++I +A+ +   RS +E SG
Sbjct  189  QARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSG  248

Query  260  NITLATLRDYALTGVDYISVGALTKHLRALDLSMR  294
            NI ++T+  +   ++DY+S G+LT   ++LD+SM+
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

848) O3I_012210 in NC_018681


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  100 bits (362),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 88/214 (42%), Positives = 142/214 (67%), Gaps = 4/214 (1%)

Query  72   SYEITGRVADGTRVTPGQSVLTVVAPTRGLLTAERTMLNLVCHLSGIatataawadavag  131
            +++   +  DG R+T+G+ VL ++++ R+LLT ER  LN++ HLSGIA+ TAA  +A+++
Sbjct  72   TFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGD  131

Query  132  tDCKIRDSRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHVVAAGSvvealravr  191
               K+ D+RKT P LR ++KYAVRVGGG NHR  L+DA ++KDNH+ A GSV  A+   R
Sbjct  132  DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQAR  191

Query  192  alaPDIA-CEVEVDSLEQldavlaenvelvlldnFPLWQTQAAVQRRNATAPGTKLESSG  250
            A AP +   EVEV+SL   +   A  V++++LDN +L Q + A+      A  +++E SG
Sbjct  192  AYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAI---TLIAGRSRIECSG  248

Query  251  GLTLEVAADYARTGVDYLAVGALTHSVRVLDLGL  284
             + +   + +   ++DY++ G+LTHS + LD+++
Sbjct  249  NIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

849) nadC in NC_010943


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score =  100 bits (363),  Expect = 9e-23, Method: Compositional matrix adjust.
 Identities = 99/238 (42%), Positives = 157/238 (66%), Gaps = 3/238 (1%)

Query  43   LLCKQDGVIAGRPWFDATHRALDPDVRIE--WRVSEGDAVTAGTVLALLHGRSRSLVSAE  100
            L+ K+ GV+AG   F+     +D++V ++   +  +GD +T+G ++  + G  RSL++ E
Sbjct  46   LFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCE  105

Query  101  RTSLNFLQTLSgtatttaryvaavagtgtRILDTRKTLPGLRLAQKYAVRCGGGDNHRFG  160
            R +LNFLQ LSG A+ TA YV A+++   +++DTRKT P LRL +KYAVR GGG NHRF 
Sbjct  106  RVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFN  165

Query  161  LYDTVMLKENHIraagslaaavaaarrqwpaLPLV-VEVEDLAQLRQALEAGCERILLDD  219
            L D++MLK+NHI A GS+  A+A AR   P + +V VEVE LA   +A  AG + I+LD+
Sbjct  166  LSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDN  225

Query  220  FSPDLRREAVRITAGRIPLEvsgsvglgglRSIAEDGVDCISIGGLTKHVQAIDLSLK  277
             S +   +A+ + AGR  +E SG++++  +  +   ++D +S G+LT   +++D+S+K
Sbjct  226  MSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMK  283

850) Halru_1261 in NC_019964


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score = 97.5 bits (351),  Expect = 7e-22, Method: Compositional matrix adjust.
 Identities = 96/227 (43%), Positives = 144/227 (64%), Gaps = 11/227 (4%)

Query  47   ERVFEYLDVDVT----DRVADGTSVDAGKPILSVEGPARDVLRGERVAVNVTGHASGIAT  102
            +RVF  +D +VT    ++  DG  + +G  +L + G+ R +L  ERVA+N   H SGIA+
Sbjct  61   QRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS  120

Query  103  RTHRAVERARQVSESVRVAATRKTTPGLRGLEKRAVVAGGGDTHRLDLSHAVMVKDNHIT  162
             T   VE   +  + ++V  TRKTTP LR +EK AV  GGG  HR++LS+A+M+KDNHI+
Sbjct  121  MTAAYVEALGD--DRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIA  178

Query  163  EMG-LERAVEHFDDRASLTTKLEVEVETpadapkaaaagadIVLLDNMDPATVRTALDRL  221
             +G +++A+ +    A++   +EVEVE+ A A  AAAAG DI++LDNM    +  A+  +
Sbjct  179  AVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLI  238

Query  222  AEAGHDDTLTEASGGITMETvadyaaagvdvvSMGSLTHSAPSLDLS  268
            A  ++     E SG I M T++ + + ++D VS GSLTHSA SLD+S
Sbjct  239  AGRSR----IECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

851) nadC in NC_015576


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score = 95.4 bits (343),  Expect = 3e-21, Method: Compositional matrix adjust.
 Identities = 85/205 (42%), Positives = 135/205 (66%), Gaps = 7/205 (3%)

Query  88   LQPGAVVLSLQADTRGLLTAERTMLNLICHLSGIATATAAWVDAISGIAGTSAQIRDTRK  147
            L +G +VL + +  R+LLT ER  LN++ HLSGIA+ TAA V+A+   ++   ++ DTRK
Sbjct  85   LTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL---GDDRIKVFDTRK  141

Query  148  TLPGLRVLQKYAVRVGGGVNHRMGLGDAALIKDNHvaaagsvaaalravra-aapevace  206
            T P LR+++KYAVRVGGG NHR  L+DA ++KDNH+AA GSV  A+   RA A+     E
Sbjct  142  TTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVE  201

Query  207  vevDSLEQFDEVLAEGPELVLLDNFPVWATQTAAQRRDSRAPGVLLESSGGLTLDSAAAY  266
            VEV+SL   +E  A G ++++LDN ++   + A     +R+    +E SG + + + + +
Sbjct  202  VEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSR---IECSGNIDMTTISRF  258

Query  267  AATGVDYLAVGALTHSVQVLDIGLD  291
             + ++DY++ G+LTHS + LD+++ 
Sbjct  259  RGLAIDYVSSGSLTHSAKSLDFSMK  283

852) Mevan_0043 in NC_009634


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score = 94.4 bits (339),  Expect = 8e-21, Method: Compositional matrix adjust.
 Identities = 85/210 (41%), Positives = 125/210 (60%), Gaps = 15/210 (7%)

Query  87   KDGDLVYGPFLEINGRTKTILTLERTVLNFLMHLSGISTKTFNVIDMVKKVNESVKIAGT  146
              GDLV    LEI G  +++LT ER  LNFL HLSGI++ T   ++ +   ++ +K+ +T
Sbjct  86   TSGDLV----LEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALG--DDRIKVFDT  139

Query  147  RKTLPGLSMVEKYAVFVGGGDTHRFRLDDMVMIKDNHIKALGIFECfkkikklsfs--kk  204
            RKT P L + EKYAV VGGG  HRF L D +M+KDNHI A+G  +      +   +  K 
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKM  199

Query  205  VEIEVDTLEQLKEVLNYKPDIVLLDNFSTEKIEYALKIILDFEKNNNFRPIIEVSGGITE  264
            VE+EV++L    E      DI++LDN S E+IE A+ +I +       R+ IE SG I  
Sbjct  200  VEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG-------RSRIECSGNIDM  252

Query  265  KNVLEYAKFNVDVISMGSLIHSARAVDISL  294
              +  +  + +D +S GSL HSA+++D+S+
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFSM  282

853) NJ7G_0686 in NC_018224


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score = 93.3 bits (335),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 90/209 (44%), Positives = 141/209 (68%), Gaps = 5/209 (2%)

Query  59   DRLVDGTAVEPGDDLLQVEGTTRDLLRGERVAVNLAGHASGIatrtrtaverarSESDDV  118
            +++ DG  + +GD +L++ G+ R LL  ERVA+N+  H SGIA+ T + VE      D +
Sbjct  77   HQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEAL--GDDRI  134

Query  119  AIAATRKTTPGLRGLEKRAVVAGGGDTHRLDLSHMVMVKDNHIAEMG-LEDAIARCRERT  177
             +  TRKTTP LR +EK AV  GGG  HR++LS+ +M+KDNHIA +G ++ AIA+ R  +
Sbjct  135  KVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA  194

Query  178  SFATKIdveveavadapraaaagadIVLLDNMTPKDTRAAVAALADHEGVLAEASGGITV  237
            +F   ++VEVE++A A  AAAAG DI++LDNM+  +   A++ +A++  +  E SG I +
Sbjct  195  PFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRI--ECSGNIDM  252

Query  238  ADVPAYAATGVDVISMGSLTHSAPVLDLS  266
            + ++ + + ++D +S GSLTHSA  LD+S
Sbjct  253  TTISRFRGLAIDYVSSGSLTHSAKSLDFS  281

854) nadC in NC_013967


> NC_007297_P1|35|G35|71909984|YP_281534.1|Streptococcus_pyogenes_MGAS5005|+|35146..36018|nadC|M5005_Spy_0170|nicotinate-nucleotide 
pyrophosphorylase
Length=290

 Score = 88.6 bits (317),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 88/205 (43%), Positives = 129/205 (63%), Gaps = 9/205 (4%)

Query  64   GDAVESGDEVLRVDGDARNVLRGERVAANVVGHASGvatttreavaaarevsdsvrvaaT  123
            GD + SGD VL + G  R++L  ERVA N + H SG+A+ T   V A  +    V    T
Sbjct  82   GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFD--T  139

Query  124  RKTTPGLRGVEKRAVVAGGGDTHRLTLSGMVMVKDNHIAELG-LEAAV---RRFAERKSF  179
            RKTTP LR  EK AV  GGG  HR+ LS+ +M+KDNHIA +G ++ A+   R +A   +F
Sbjct  140  RKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYA---PF  196

Query  180  ATKLEVEVETPEMGERAAAAGADIVLFDNLPPEAVREGVSRLPEGVISEASGDITLETLP  239
               +EVEVE+   +E AAAAG DI+++DN++ E + ++++ ++     E SG+I + T++
Sbjct  197  VKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTIS  256

Query  240  AYADTGVDVVSMGWLTHSAPSSDFS  264
             + + ++D VS G LTHSA S DFS
Sbjct  257  RFRGLAIDYVSSGSLTHSAKSLDFS  281